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David Spector

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Michael R Hübner; Mélanie A Eckersley-Maslin; David L Spector
Chromatin organization and transcriptional regulation.
Melanie A Eckersley-Maslin; Zsolt Lazar; Jan H Bergmann; David L Spector
Lamin A/C is expressed in pluripotent mouse embryonic stem cells.
Bin Zhang; Chaolin Zhang; Jie Wu; Xiaokun Xiao; Gayatri Arun; Gourab Bhattacharjee; Carmen J Booth; Gene Hung; Zsolt Lazar; Yuntao S Mao; David L Spector
The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult.

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All Publications

2013: Michael R Hübner; Mélanie A Eckersley-Maslin; David L Spector
Chromatin organization and transcriptional regulation.
Current opinion in genetics & development 2013;23(2):89-95.
2013: Melanie A Eckersley-Maslin; Zsolt Lazar; Jan H Bergmann; David L Spector
Lamin A/C is expressed in pluripotent mouse embryonic stem cells.
Nucleus (Austin, Tex.) 2013;4(1):53-60.
2012: Bin Zhang; Chaolin Zhang; Jie Wu; Xiaokun Xiao; Gayatri Arun; Gourab Bhattacharjee; Carmen J Booth; Gene Hung; Zsolt Lazar; Yuntao S Mao; David L Spector
The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult.
Cell reports 2012;2(1):111-23.
2011: Yuntao S Mao; Bin Zhang; David L Spector
Biogenesis and function of nuclear bodies.
Trends in genetics : TIG 2011;27(8):295-306.
2011: David L Spector; Angus I Lamond
Nuclear speckles.
Cold Spring Harbor perspectives in biology 2011;3(2):.
2011: Yuntao S Mao; Hongjae Sunwoo; Bin Zhang; David L Spector
Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs.
Nature cell biology 2011;13(1):95-101.
2010: Kannanganattu V Prasanth; Matthew Camiolo; Grace Chan; Vidisha Tripathi; Laurence Denis; Tetsuya Nakamura; Michael R Hübner; David L Spector
Nuclear organization and dynamics of 7SK RNA in regulating gene expression.
Molecular biology of the cell 2010;21(23):4184-96.
2010: Delphine Bernard; Kannanganattu V Prasanth; Vidisha Tripathi; Sabrina Colasse; Tetsuya Nakamura; Zhenyu Xuan; Michael Q Zhang; Frédéric Sedel; Laurent Jourdren; Fanny Coulpier; Antoine Triller; David L Spector; Alain Bessis
A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression.
The EMBO journal 2010;29(18):3082-93.
2010: M R Hübner; David L Spector
Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation.
Cold Spring Harbor symposia on quantitative biology 2010;75():43-9.
2010: Michael R Hübner; David L Spector
Chromatin dynamics.
Annual review of biophysics 2010;39():471-89.
2009: Jeremy E Wilusz; Hongjae Sunwoo; David L Spector
Long noncoding RNAs: functional surprises from the RNA world.
Genes & development 2009;23(13):1494-504.
2008: Jeremy E Wilusz; Susan M Freier; David L Spector
3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA.
Cell 2008;135(5):919-32.
2008: R Ileng Kumaran; Rajika Thakar; David L Spector
Chromatin dynamics and gene positioning.
Cell 2008;132(6):929-34.
2008: R Ileng Kumaran; David L Spector
A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence.
The Journal of cell biology 2008;180(1):51-65.
2007: Yuda Fang; David L Spector
Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants.
Current biology : CB 2007;17(9):818-23.
2007: Kannanganattu V Prasanth; David L Spector
Eukaryotic regulatory RNAs: an answer to the 'genome complexity' conundrum.
Genes & development 2007;21(1):11-42.
2006: David L Spector
SnapShot: Cellular bodies.
Cell 2006;127(5):1071.
2006: Hansol Lee; John C Quinn; Kannanganattu V Prasanth; Victoria A Swiss; Kyriakos D Economides; Marie M Camacho; David L Spector; Cory Abate-Shen
PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein.
Genes & development 2006;20(7):784-94.
2006: Joan C Ritland Politz; Richard A Tuft; Kannanganattu V Prasanth; Nina Baudendistel; Kevin E Fogarty; Lawrence Lifshitz; Jörg Langowski; David L Spector; Thoru Pederson
Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm.
Molecular biology of the cell 2006;17(3):1239-49.
2005: Bruce P May; Zachary Lippman; Yuda Fang; David L Spector; Robert A Martienssen
Differential regulation of strand-specific transcripts from Arabidopsis centromeric satellite repeats.
PLoS genetics 2005;1(6):e79.
2005: Yuda Fang; David L Spector
Centromere positioning and dynamics in living Arabidopsis plants.
Molecular biology of the cell 2005;16(12):5710-8.
2005: Kannanganattu V Prasanth; Supriya G Prasanth; Zhenyu Xuan; Stephen A Hearn; Susan M Freier; C Frank Bennett; Michael Q Zhang; David L Spector
Regulating gene expression through RNA nuclear retention.
Cell 2005;123(2):249-63.
2004: Paula Bubulya; Kannanganattu V Prasanth; Thomas J Deerinck; Daniel Gerlich; Joël Beaudouin; Mark H Ellisman; Jan Ellenberg; David L Spector
Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei.
The Journal of cell biology 2004;167(1):51-63.
2004: David L Spector
Stopping for FISH and chips along the chromatin fiber superhighway.
Molecular cell 2004;15(6):844-6.
2004: Noriko Saitoh; Chris Spahr; Scott D Patterson; Paula Bubulya; Andrew F. Neuwald; David L Spector
Proteomic analysis of interchromatin granule clusters.
Molecular biology of the cell 2004;15(8):3876-90.
2004: Supriya G Prasanth; Kannanganattu V Prasanth; Khalid Siddiqui; David L Spector; Bruce Stillman
Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance.
The EMBO journal 2004;23(13):2651-63.
2004: Takao Ono; Yuda Fang; David L Spector; Tatsuya Hirano
Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells.
Molecular biology of the cell 2004;15(7):3296-308.
2004: Yaron Shav-Tal; Xavier Darzacq; Shailesh M Shenoy; Dahlene Fusco; Susan Janicki; David L Spector; Robert H Singer
Dynamics of single mRNPs in nuclei of living cells.
Science (New York, N.Y.) 2004;304(5678):1797-800.
2004: Yuda Fang; Stephen A Hearn; David L Spector
Tissue-specific expression and dynamic organization of SR splicing factors in Arabidopsis.
Molecular biology of the cell 2004;15(6):2664-73.
2004: Paula Bubulya; David L Spector
"On the move"ments of nuclear components in living cells.
Experimental cell research 2004;296(1):4-11.
2004: Susan Janicki; Toshiro Tsukamoto; Simone E Salghetti; William P Tansey; Ravi Sachidanandam; Kannanganattu V Prasanth; Thomas Ried; Yaron Shav-Tal; Edouard Bertrand; Robert H Singer; David L Spector
From silencing to gene expression: real-time analysis in single cells.
Cell 2004;116(5):683-98.
2003: Masashi Narita; Sabrina Nũnez; Edith Heard; Masako Narita; Athena W Lin; Stephen A Hearn; David L Spector; Gregory J Hannon; Scott W Lowe
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
Cell 2003;113(6):703-16.
2003: Susan Janicki; David L Spector
Nuclear choreography: interpretations from living cells.
Current opinion in cell biology 2003;15(2):149-57.
2003: Kannanganattu V Prasanth; Paula Bubulya; Supriya G Prasanth; David L Spector
Sequential entry of components of the gene expression machinery into daughter nuclei.
Molecular biology of the cell 2003;14(3):1043-57.
2003: David L Spector
The dynamics of chromosome organization and gene regulation.
Annual review of biochemistry 2003;72():573-608.
2003: David L Spector; Susan Gasser
A molecular dissection of nuclear function. Conference on the dynamic nucleus: questions and implications.
EMBO reports 2003;4(1):18-23.
2002: Paula Bubulya; David L Spector
Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing.
The Journal of cell biology 2002;156(3):425-36.
2002: Masafumi Muratani; Daniel Gerlich; Susan Janicki; Matthias Gebhard; Roland Eils; David L Spector
Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus.
Nature cell biology 2002;4(2):106-10.
2002: Barbara A Boggs; Peter Cheung; Edith Heard; David L Spector; A Craig Chinault; C David Allis
Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes.
Nature genetics 2002;30(1):73-6.
2001: Edith Heard; Claire Rougeulle; Danielle Arnaud; Philip Avner; C David Allis; David L Spector
Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation.
Cell 2001;107(6):727-38.
2000: T Tsukamoto; N Hashiguchi; Susan Janicki; T Tumbar; Andrew S Belmont; David L Spector
Visualization of gene activity in living cells.
Nature cell biology 2000;2(12):871-8.
2000: P J Mintz; David L Spector
Compartmentalization of RNA processing factors within nuclear speckles.
Journal of structural biology 2000;129(2-3):241-51.
2000: Roland Eils; Daniel Gerlich; W Tvaruskó; David L Spector; T Misteli
Quantitative imaging of pre-mRNA splicing factors in living cells.
Molecular biology of the cell 2000;11(2):413-8.
2000: P Lorenz; T Misteli; Brenda F Baker; C Frank Bennett; David L Spector
Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides.
Nucleic acids research 2000;28(2):582-92.
1999: P J Mintz; Scott D Patterson; Andrew F. Neuwald; Chris Spahr; David L Spector
Purification and biochemical characterization of interchromatin granule clusters.
The EMBO journal 1999;18(15):4308-20.
1999: W Tvaruskó; Martin Bentele; T Misteli; Ruediger Rudolf; Christoph Kaether; David L Spector; Hans-Hermann Gerdes; Roland Eils
Time-resolved analysis and visualization of dynamic processes in living cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7950-5.
1998: T Misteli; Javier F Cáceres; Jade Clement; Adrian R Krainer; Miles F Wilkinson; David L Spector
Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo.
The Journal of cell biology 1998;143(2):297-307.
1998: Sui Huang; Thomas J Deerinck; M H Ellisman; David L Spector
The perinucleolar compartment and transcription.
The Journal of cell biology 1998;143(1):35-47.
1998: T Misteli; David L Spector
The cellular organization of gene expression.
Current opinion in cell biology 1998;10(3):323-31.
1998: P Lorenz; Brenda F Baker; C Frank Bennett; David L Spector
Phosphorothioate antisense oligonucleotides induce the formation of nuclear bodies.
Molecular biology of the cell 1998;9(5):1007-23.
1997: Javier F Cáceres; T Misteli; Gavin Screaton; David L Spector; Adrian R Krainer
Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity.
The Journal of cell biology 1997;138(2):225-38.
1997: S Huang; Thomas J Deerinck; Mark H Ellisman; David L Spector
The dynamic organization of the perinucleolar compartment in the cell nucleus.
The Journal of cell biology 1997;137(5):965-74.
1997: S Huang; A Mayeda; Adrian R Krainer; David L Spector
RCC1 and nuclear organization.
Molecular biology of the cell 1997;8(6):1143-57.
1997: T Misteli; Javier F Cáceres; David L Spector
The dynamics of a pre-mRNA splicing factor in living cells.
Nature 1997;387(6632):523-7.
1996: David L Spector
Nuclear organization and gene expression.
Experimental cell research 1996;229(2):189-97.
1996: Tom Misteli; David L Spector
Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors.
Molecular biology of the cell 1996;7(10):1559-72.
1996: S Huang; David L Spector
Dynamic organization of pre-mRNA splicing factors.
Journal of cellular biochemistry 1996;62(2):191-7.
1996: S Huang; David L Spector
Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription.
The Journal of cell biology 1996;133(4):719-32.
1996: T Tani; R J Derby; Y Hiraoka; David L Spector
Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport.
Molecular biology of the cell 1996;7(1):173-92.
1995: T Tani; R J Derby; Y Hiraoka; David L Spector
Nucleolar accumulation of poly (A)+ RNA in heat-shocked yeast cells: implication of nucleolar involvement in mRNA transport.
Molecular biology of the cell 1995;6(11):1515-34.
1994: L F Jiménez-García; M L Segura-Valdez; R L Ochs; Lawrence Rothblum; Ross D Hannan; David L Spector
Nucleologenesis: U3 snRNA-containing prenucleolar bodies move to sites of active pre-rRNA transcription after mitosis.
Molecular biology of the cell 1994;5(9):955-66.
1994: Thomas J Deerinck; Maryann E Martone; Varda Lev-Ram; D P Green; Roger Y Tsien; David L Spector; S Huang; Mark H Ellisman
Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy.
The Journal of cell biology 1994;126(4):901-10.
1994: S Huang; Thomas J Deerinck; M H Ellisman; David L Spector
In vivo analysis of the stability and transport of nuclear poly(A)+ RNA.
The Journal of cell biology 1994;126(4):877-99.
1994: R T O'Keefe; A Mayeda; C L Sadowski; Adrian R Krainer; David L Spector
Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors.
The Journal of cell biology 1994;124(3):249-60.
1993: David L Spector; S Landon; R T O'Keefe
Organization of RNA polymerase II transcription and pre-mRNA splicing within the mammalian cell nucleus.
Biochemical Society transactions 1993;21(4):918-20.
1993: L F Jiménez-García; S R Green; Michael B Mathews; David L Spector
Organization of the double-stranded RNA-activated protein kinase DAI and virus-associated VA RNAI in adenovirus-2-infected HeLa cells.
Journal of cell science 1993;106 ( Pt 1)():11-22.
1993: David L Spector
Nuclear organization of pre-mRNA processing.
Current opinion in cell biology 1993;5(3):442-7.
1993: L F Jiménez-García; David L Spector
In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism.
Cell 1993;73(1):47-59.
1993: David L Spector
Macromolecular domains within the cell nucleus.
Annual review of cell biology 1993;9():265-315.
1993: David L Spector; R T O'Keefe; L F Jiménez-García
Dynamics of transcription and pre-mRNA splicing within the mammalian cell nucleus.
Cold Spring Harbor symposia on quantitative biology 1993;58():799-805.
1992: David L Spector; G Lark; S Huang
Differences in snRNP localization between transformed and nontransformed cells.
Molecular biology of the cell 1992;3(5):555-69.
1992: R T O'Keefe; S C Henderson; David L Spector
Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences.
The Journal of cell biology 1992;116(5):1095-110.
1991: S Huang; David L Spector
Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors.
Genes & development 1991;5(12A):2288-302.
1991: I J Yu; David L Spector; Y S Bae; D R Marshak
Immunocytochemical localization of casein kinase II during interphase and mitosis.
The Journal of cell biology 1991;114(6):1217-32.
1990: J A Potashkin; R J Derby; David L Spector
Differential distribution of factors involved in pre-mRNA processing in the yeast cell nucleus.
Molecular and cellular biology 1990;10(7):3524-34.
1989: G C Conway; Adrian R Krainer; David L Spector; Richard J Roberts
Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing.
Molecular and cellular biology 1989;9(12):5273-80.
1987: David L Spector; R A Watt; N F Sullivan
The v- and c-myc oncogene proteins colocalize in situ with small nuclear ribonucleoprotein particles.
Oncogene 1987;1(1):5-12.
1986: H C Smith; R L Ochs; E A Fernandez; David L Spector
Macromolecular domains containing nuclear protein p107 and U-snRNP protein p28: further evidence for an in situ nuclear matrix.
Molecular and cellular biochemistry 1986;70(2):151-68.
1986: C F Bennett; David L Spector; Lynn Yeoman
Nonhistone protein BA is a glutathione S-transferase localized to interchromatinic regions of the cell nucleus.
The Journal of cell biology 1986;102(2):600-9.
1986: N F Sullivan; R A Watt; M R Delannoy; C L Green; David L Spector
Colocalization of the myc oncogene protein and small nuclear ribonucleoprotein particles.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():943-7.
1985: H C Smith; David L Spector; C L Woodcock; R L Ochs; J Bhorjee
Alterations in chromatin conformation are accompanied by reorganization of nonchromatin domains that contain U-snRNP protein p28 and nuclear protein p107.
The Journal of cell biology 1985;101(2):560-7.
1985: Harris Busch; R L Ochs; H C Smith; David L Spector
Nuclear antigenic structures.
Scandinavian journal of rheumatology. Supplement 1985;56():10-21.
1984: David L Spector; R L Ochs; Harris Busch
Silver staining, immunofluorescence, and immunoelectron microscopic localization of nucleolar phosphoproteins B23 and C23.
Chromosoma 1984;90(2):139-48.