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Tim Spector

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Marina Cecelja; Rene Botnar; Gerald F Greil; Tarique Hussain; Alireza Moayyeri; Rebecca Preston; Tim D Spector; Philip Chowienczyk
Multimodality imaging of subclinical aortic atherosclerosis: relation of aortic stiffness to calcification and plaque in female twins.
Kenan Direk; Mario Falchi; Tim D Spector; William Astle; Marina Cecelja; Phil Chowienczyk; Toby Andrew
The relationship between DXA-based and anthropometric measures of visceral fat and morbidity in women.
Alexander W Drong; Elin Grundberg; Asa K Hedman; Fredrik Karpe; Cecilia M Lindgren; Mark I McCarthy; Eshwar Meduri; George Nicholson; Mattias Rantalainen; So-Youn Shin; Kerrin S Small; Nicole Soranzo; Tim D Spector; Jordana T Bell; Panos Deloukas
The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue.

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2013: Marina Cecelja; Rene Botnar; Gerald F Greil; Tarique Hussain; Alireza Moayyeri; Rebecca Preston; Tim D Spector; Philip Chowienczyk
Multimodality imaging of subclinical aortic atherosclerosis: relation of aortic stiffness to calcification and plaque in female twins.
Hypertension 2013;61(3):609-14.
2013: Kenan Direk; Mario Falchi; Tim D Spector; William Astle; Marina Cecelja; Phil Chowienczyk; Toby Andrew
The relationship between DXA-based and anthropometric measures of visceral fat and morbidity in women.
BMC cardiovascular disorders 2013;13():25.
2013: Alexander W Drong; Elin Grundberg; Asa K Hedman; Fredrik Karpe; Cecilia M Lindgren; Mark I McCarthy; Eshwar Meduri; George Nicholson; Mattias Rantalainen; So-Youn Shin; Kerrin S Small; Nicole Soranzo; Tim D Spector; Jordana T Bell; Panos Deloukas
The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue.
PloS one 2013;8(2):e55923.
2013: Stephan Menzel; Helen Rooks; Tim D Spector; Chad Garner; Swee Lay Thein
HbA2 levels in normal adults are influenced by two distinct genetic mechanisms.
British journal of haematology 2013;160(1):101-5.
2013: Gavin Hudson; John Loughlin; Andrew McCaskie; William E R Ollier; Kalliope Panoutsopoulou; Stuart H Ralston; Nigel W Rayner; Mike R Reed; David Samuels; Lorraine Southam; Tim D Spector; Ana M Valdes; Gillian A Wallis; J Mark Wilkinson; Ian Wilson; Eleftheria Zeggini; Nigel Arden; Fraser Birrell; Ian Carluke; Andrew Carr; Kay Chapman; Patrick F Chinnery; Panos Deloukas; Michael Doherty
No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls.
Annals of the rheumatic diseases 2013;72(1):136-9.
2012: Benjamin Rhodes; Amy L Roberts; Georg Schett; Tim D Spector; George Tzircotis; Barbara G Fürnrohr; Timothy J Vyse
The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes.
Annals of the rheumatic diseases 2012;71(12):2028-34.
2012: Shelby Chew; Zari Dastani; Frank Dudbridge; Joshua R Lewis; J Brent Richards; Nicole Soranzo; Tim D Spector; Gabriela L Surdulescu; Suzanne J Brown; Scott G Wilson
Copy number variation of the APC gene is associated with regulation of bone mineral density.
Bone 2012;51(5):939-43.
2012: Pei-Chien Tsai; Tim D Spector; Jordana T Bell
Using epigenome-wide association scans of DNA methylation in age-related complex human traits.
Epigenomics 2012;4(5):511-26.
2012: J Brent Richards; Hou-Feng Zheng; Tim D Spector
Genetics of osteoporosis from genome-wide association studies: advances and challenges.
Nature reviews. Genetics 2012;13(8):576-88.
2012: K M Leyland; A Soni; Tim D Spector; C Cooper; L M Goulston; D J Hart; M K Javaid; A Judge; A Kiran; Nigel K Arden
The natural history of radiographic knee osteoarthritis: a fourteen-year population-based cohort study.
Arthritis and rheumatism 2012;64(7):2243-51.
2012: A Soni; Tim D Spector; C Cooper; L Goulston; D J Hart; M K Javaid; A Kiran; K M Leyland; Nigel K Arden
Prevalence of reported knee pain over twelve years in a community-based cohort.
Arthritis and rheumatism 2012;64(4):1145-52.
2012: Frances M K Williams; Baohong Zhang; Daniel Ziemek; Joel C Stephens; Gabriela L Surdulescu; Jun Wang; Dandan Cao; Brian Dougherty; Juliette Harris; Ian Harrow; Wen He; Dylan Hodgkiss; Craig L Hyde; Xin Jin; Sally John; Anders Malarstig; Robert McEwen; Stephen B McMahon; Yasin Memari; Cristina Menni; Ketan Patel; Serena Scollen; Yujian Shi; So-Youn Shin; Ben Sidders; Nicole Soranzo; Tim D Spector
Genes contributing to pain sensitivity in the normal population: an exome sequencing study.
PLoS genetics 2012;8(12):e1003095.
2012: Christopher J Hammond; S H Melissa Liew; John M Nolan; Tim D Spector; Frederik J Van Kuijk; Stephen Beatty; Clare E Gilbert
The heritability of macular response to supplemental lutein and zeaxanthin: a classic twin study.
Investigative ophthalmology & visual science 2012;53(8):4963-8.
2012: Lisa E Wolber; Tim D Spector; Claire J Steves; Frances M K Williams
Hearing ability with age in northern European women: a new web-based approach to genetic studies.
PloS one 2012;7(4):e35500.
2012: Jordana T Bell; Emma L Dempster; Emmanouil T Dermitzakis; Daniel Glass; Elin Grundberg; Asa K Hedman; Massimo Mangino; Mark I McCarthy; Jonathan Mill; Robin M Murray; Alexandra Nica; James Nisbet; Ruth Pidsley; So-Youn Shin; Kerrin S Small; Tim D Spector; Pei-Chien Tsai; Ana Valdes; Tsun-Po Yang; Guangju Zhai; Feng Zhang; Panos Deloukas
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.
PLoS genetics 2012;8(4):e1002629.
2012: Josine L Min; Matt J Neville; George Nicholson; Andreas Petri; Fredrik H Pettersson; Nigel W Rayner; Tim D Spector; Mary Travers; Quin F Wills; Maxine Allen; Kristian Almstrup; Amy Barrett; John Broxholme; Jane Cheeseman; Jan Fleckner; Ingileif Halgrimsdottir; Chris C Holmes; Fredrik Karpe; Cecilia M Lindgren; Reedik Mägi; Mark I McCarthy; Krina T Zondervan
Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.
PLoS genetics 2012;8(2):e1002505.
2011: Michael A Ghebre; Alan J Hakim; Deborah J Hart; Bernet S Kato; Tim D Spector; Vicky Thompson; Nigel K Arden; Guangju Zhai
Association between DHEAS and bone loss in postmenopausal women: a 15-year longitudinal population-based study.
Calcified tissue international 2011;89(4):295-302.
2011: George Nicholson; Jeremy K Nicholson; Mattias Rantalainen; N William Rayner; Ugis Sarkans; Tim D Spector; Karsten Suhre; Henrik Toft; Juris Viksna; Krina T Zondervan; Jerzy Adamski; Kourosh R Ahmadi; Maxine Allen; Amy Barrett; Dorrit Baunsgaard; Peter Donnelly; Marc-Emmanuel Dumas; Johan H Faber; Elaine Holmes; Thomas Illig; Maria Krestyaninova; Jia V Li; John C Lindon; Anthony D Maher; Daniel Malmodin; Mark I McCarthy; Josine L Min; Sudeshna Guha Neogi; Chris C Holmes
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
PLoS genetics 2011;7(9):e1002270.
2011: S Chew; Ben Mullin; J R Lewis; Tim D Spector; Richard L Prince; Scott G Wilson
Homozygous deletion of the UGT2B17 gene is not associated with osteoporosis risk in elderly Caucasian women.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2011;22(6):1981-6.
2011: F M K Williams; M Popham; D J Hart; E de Schepper; S Bierma-Zeinstra; Albert Hofman; André G Uitterlinden; N K Arden; C Cooper; Tim D Spector; Ana M Valdes; J van Meurs
GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women.
Arthritis and rheumatism 2011;63(3):708-12.
2011: Jordana T Bell; Tim D Spector
A twin approach to unraveling epigenetics.
Trends in genetics : TIG 2011;27(3):116-25.
2011: Ana M Valdes; Frances L Vaughn; Weiya Zhang; Nigel K Arden; Cyrus Cooper; Elaine M Dennison; Sally A Doherty; Mark H Edwards; Karen A Jameson; M Kassim Javaid; Paul E Leaverton; Rose A Maciewicz; Kenneth R Muir; Evadnie Rampersaud; Tim D Spector; Michael Doherty
Role of the Nav1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain.
Arthritis care & research 2011;63(3):440-4.
2011: Jacqueline M Vink; Dorret I Boomsma; Sarah E Medland; M H M De Moor; Janine H Stubbe; Belinda K Cornes; Nicholas G Martin; Axel Skytthea; Kirsten Ohm Kyvik; Richard J Rose; Urho M Kujala; Jaakko Kaprio; Jennifer R Harris; Nancy L Pedersen; Lynn F Cherkas; Tim D Spector; Eco J C De Geus
Variance components models for physical activity with age as modifier: a comparative twin study in seven countries.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2011;14(1):25-34.
2011: Samantha J Fahy; Cong Sun; Gu Zhu; Paul R Healey; Tim D Spector; Nicolas G Martin; Paul Mitchell; Tien Y Wong; David A Mackey; Christopher J Hammond; Toby Andrew
The relationship between retinal arteriolar and venular calibers is genetically mediated, and each is associated with risk of cardiovascular disease.
Investigative ophthalmology & visual science 2011;52(2):975-81.
2011: Toby Andrew; Cassandra D Calloway; Philip Chowienczyk; Gail Clement; Raj Gill; Sang Hoon Lee; Tim D Spector; Sarah Stuart; Ana M Valdes
A twin study of mitochondrial DNA polymorphisms shows that heteroplasmy at multiple sites is associated with mtDNA variant 16093 but not with zygosity.
PloS one 2011;6(8):e22332.
2011: Ana M Valdes; Timothy J Vyse; Margaret Wheeler; Weiya Zhang; Cyrus Cooper; Elaine M Dennison; Michael Doherty; Sally A Doherty; Deborah J Hart; Thorvaldur Ingvarsson; Ingileif Jonsdottir; Gudbjorn F Jonsson; Helgi Jonsson; Irina Kerna; Kai E Kisand; Rose A Maciewicz; Massimo Mangino; Sarah Metrustry; David L Morris; Kenneth R Muir; Tim D Spector; Kari Stefansson; Unnur Styrkarsdottir; Agu Tamm; Ann Tamm; Nigel K Arden
Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations.
PloS one 2011;6(8):e23371.
2011: Josine L Min; Andrew P Morris; Chris Newton-Cheh; Markus Perola; Fredrik H Pettersson; Jiannis Ragoussis; J Brent Richards; Nicole Soranzo; Tim D Spector; Ida Surakka; Gabriela L Surdulescu; Jennifer M Taylor; Tim Watts; Kourosh R Ahmadi; John Broxholme; Lon R Cardon; Christian Gieger; Cecilia M Lindgren; Ernesto Lowy; Krina T Zondervan
The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits.
PloS one 2011;6(7):e22070.
2011: Ana M Valdes; Tim D Spector
Genetic epidemiology of hip and knee osteoarthritis.
Nature reviews. Rheumatology 2011;7(1):23-32.
2010: E Noon; Swaran P Singh; Jack Cuzick; Tim D Spector; F M K Williams; M L Frost; A Howell; M Harvie; R Eastell; R E Coleman; Ignac Fogelman; Glen M Blake
Significant differences in UK and US female bone density reference ranges.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2010;21(11):1871-80.
2010: Daniel Glass; Leopold Parts; David Knowles; Abraham Aviv; Tim D Spector
No correlation between childhood maltreatment and telomere length.
Biological psychiatry 2010;68(6):e21-2; author reply e23-4.
2010: Vijay Panicker; Scott G Wilson; John P Walsh; J Brent Richards; Suzanne J Brown; John P Beilby; Alexandra P Bremner; Gabriela L Surdulescu; Emad Qweitin; Irina Gillham-Nasenya; Nicole Soranzo; Ee Mun Lim; Stephen J Fletcher; Tim D Spector
A locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study.
American journal of human genetics 2010;87(3):430-5.
2010: Frances M K Williams; Tim D Spector; Alex J MacGregor
Pain reporting at different body sites is explained by a single underlying genetic factor.
Rheumatology (Oxford, England) 2010;49(9):1753-5.
2010: Ana M Valdes; Nigel K Arden; A Tamm; Kai E Kisand; S Doherty; E Pola; Cyrus Cooper; A Tamm; K R Muir; I Kerna; D Hart; F O'Neil; W Zhang; Tim D Spector; R A Maciewicz; Michael Doherty
A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2010;18(5):699-704.
2010: Ana M Valdes; Tim D Spector
The genetic epidemiology of osteoarthritis.
Current opinion in rheumatology 2010;22(2):139-43.
2010: Ana M Valdes; Tim D Spector
The clinical relevance of genetic susceptibility to osteoarthritis.
Best practice & research. Clinical rheumatology 2010;24(1):3-14.
2010: Frances M K Williams; Jane Skinner; Tim D Spector; Aedin Cassidy; Ian M Clark; Rosemary Davidson; Alex J MacGregor
Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action.
BMC musculoskeletal disorders 2010;11():280.
2010: Lynn F Cherkas; Juliette M Harris; Elana Levinson; Tim D Spector; Barbara Prainsack
A survey of UK public interest in internet-based personal genome testing.
PloS one 2010;5(10):e13473.
2009: Anna C Need; Deborah K Attix; Jill M McEvoy; Elizabeth T Cirulli; Kristen L Linney; Priscilla Hunt; Dongliang Ge; Erin L Heinzen; Jessica M Maia; Kevin V Shianna; Michael E Weale; Lynn F Cherkas; Gail Clement; Tim D Spector; Greg Gibson; David B Goldstein
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
Human molecular genetics 2009;18(23):4650-61.
2009: Ana M Valdes; Tim D Spector; S Doherty; M Wheeler; D J Hart; M Doherty
Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations.
Annals of the rheumatic diseases 2009;68(12):1916-20.
2009: Francis Carbonaro; Toby Andrew; David A Mackey; Terri L Young; Tim D Spector; Christopher J Hammond
Repeated measures of intraocular pressure result in higher heritability and greater power in genetic linkage studies.
Investigative ophthalmology & visual science 2009;50(11):5115-9.
2009: Guangju Zhai; J B J van Meurs; Gregory Livshits; I Meulenbelt; Ana M Valdes; N Soranzo; D Hart; F Zhang; Bernet S Kato; J B Richards; F M K Williams; M Inouye; M Kloppenburg; Panos Deloukas; E Slagboom; André G Uitterlinden; Tim D Spector
A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.
Journal of medical genetics 2009;46(9):614-6.
2009: Ben Mullin; Richard L Prince; Cyril Mamotte; Tim D Spector; Deborah J Hart; Frank Dudbridge; Scott G Wilson
Further genetic evidence suggesting a role for the RhoGTPase-RhoGEF pathway in osteoporosis.
Bone 2009;45(2):387-91.
2009: Gregory Livshits; Guangju Zhai; Deborah J Hart; Bernet S Kato; Huizhong Wang; Frances M K Williams; Tim D Spector
Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: The Chingford Study.
Arthritis and rheumatism 2009;60(7):2037-45.
2009: M Mangino; J B Richards; N Soranzo; G Zhai; A Aviv; A M Valdes; N J Samani; Panos Deloukas; Tim D Spector
A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length.
Journal of medical genetics 2009;46(7):451-4.
2009: Guangju Zhai; Toby Andrew; Bernet S Kato; G M Blake; Tim D Spector
Genetic and environmental determinants on bone loss in postmenopausal Caucasian women: a 14-year longitudinal twin study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2009;20(6):949-53.
2009: Frances M K Williams; Angela M Carter; Bernet S Kato; Mario Falchi; Lise Bathum; Gabriela L Surdulescu; Kirsten Ohm Kyvik; Aarno Palotie; Tim D Spector; Peter J Grant
Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(4):600-5.
2009: Jacqueline M Vink; August B Smit; Eco J C De Geus; Patrick F Sullivan; Gonneke Willemsen; Jouke-Jan Hottenga; Johannes H Smit; Witte J G Hoogendijk; Frans G Zitman; Leena Peltonen; Jaakko Kaprio; Nancy L Pedersen; Patrik K E Magnusson; Tim D Spector; Kirsten Ohm Kyvik; Katherine I Morley; Andrew C Heath; Nicholas G Martin; Rudi G J Westendorp; P Eline Slagboom; Henning Tiemeier; Albert Hofman; André G Uitterlinden; Yurii S Aulchenko; Najaf Amin; C.M. Duijn; Brenda W Penninx; Dorret I Boomsma
Genome-wide association study of smoking initiation and current smoking.
American journal of human genetics 2009;84(3):367-79.
2009: Alex J MacGregor; Q Li; Tim D Spector; F M K Williams
The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee.
Rheumatology (Oxford, England) 2009;48(3):277-80.
2009: Lisa E Creary; Colin A McKenzie; Stephan Menzel; Neil A Hanchard; Veronica Taylor; Ian Hambleton; Tim D Spector; Terrence E Forrester; Swee Lay Thein
Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic loci controlling fetal haemoglobin.
British journal of haematology 2009;144(6):954-60.
2009: Aedin Cassidy; Paula M L Skidmore; Eric B Rimm; Ailsa Welch; Susan J Fairweather-Tait; Jane Skinner; Keith Burling; J B Richards; Tim D Spector; Alex J MacGregor
Plasma adiponectin concentrations are associated with body composition and plant-based dietary factors in female twins.
The Journal of nutrition 2009;139(2):353-8.
2009: Daniel Glass; Marko Lens; Ramasamyiyer Swaminathan; Tim D Spector; Veronique Bataille
Pigmentation and vitamin D metabolism in Caucasians: low vitamin D serum levels in fair skin types in the UK.
PloS one 2009;4(8):e6477.
2009: Margarida C Lopes; Toby Andrew; Francis Carbonaro; Tim D Spector; Christopher J Hammond
Estimating heritability and shared environmental effects for refractive error in twin and family studies.
Investigative ophthalmology & visual science 2009;50(1):126-31.
2008: J Brent Richards; Xin Yuan; Frank Geller; Dawn Waterworth; Veronique Bataille; Daniel Glass; Kijoung Song; Gerard Waeber; Peter Vollenweider; Katja K H Aben; Lambertus A Kiemeney; Gudmundur Bragi Walters; Nicole Soranzo; Unnur Thorsteinsdottir; Augustine Kong; Thorunn Rafnar; Panos Deloukas; Patrick Sulem; Hreinn Stefansson; Kari Stefansson; Tim D Spector; Vincent Mooser
Male-pattern baldness susceptibility locus at 20p11.
Nature genetics 2008;40(11):1282-4.
2008: Toby Andrew; Nikolas Maniatis; Francis Carbonaro; S H Melissa Liew; Winston Lau; Tim D Spector; Christopher J Hammond
Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping.
PLoS genetics 2008;4(10):e1000220.
2008: F M K Williams; Lynn F Cherkas; M L Bertolaccini; V Murru; Gabriela L Surdulescu; G R V Hughes; Munther A Khamashta; Tim D Spector; Alex J MacGregor
Migraine and antiphospholipid antibodies: no association found in migraine-discordant monozygotic twins.
Cephalalgia : an international journal of headache 2008;28(10):1048-52.
2008: J B Richards; A M Valdes; Jeffrey P Gardner; Bernet S Kato; A Siva; M Kimura; X Lu; M J Brown; Abraham Aviv; Tim D Spector
Homocysteine levels and leukocyte telomere length.
Atherosclerosis 2008;200(2):271-7.
2008: Vijay Panicker; Scott G Wilson; Tim D Spector; Suzanne J Brown; Bernet S Kato; Peter W Reed; Mario Falchi; J Brent Richards; Gabriela L Surdulescu; Ee Mun Lim; Steven J Fletcher; John P Walsh
Genetic loci linked to pituitary-thyroid axis set points: a genome-wide scan of a large twin cohort.
The Journal of clinical endocrinology and metabolism 2008;93(9):3519-23.
2008: Francis Carbonaro; Toby Andrew; David A Mackey; Tim D Spector; Christopher J Hammond
The heritability of corneal hysteresis and ocular pulse amplitude: a twin study.
Ophthalmology 2008;115(9):1545-9.
2008: F Carbonaro; Toby Andrew; David A Mackey; Tim D Spector; Christopher J Hammond
Heritability of intraocular pressure: a classical twin study.
The British journal of ophthalmology 2008;92(8):1125-8.
2008: G Zhai; Deborah J Hart; Ana M Valdes; Bernet S Kato; J Brent Richards; A Hakim; Tim D Spector
Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2008;19(8):1211-7.
2008: Ben Mullin; Richard L Prince; Ian M Dick; F M A Islam; D J Hart; Tim D Spector; Amanda Devine; Frank Dudbridge; Scott G Wilson
Bone structural effects of variation in the TNFRSF1B gene encoding the tumor necrosis factor receptor 2.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2008;19(7):961-8.
2008: Ben Mullin; Richard L Prince; Ian M Dick; Deborah J Hart; Tim D Spector; Frank Dudbridge; Scott G Wilson
Identification of a role for the ARHGEF3 gene in postmenopausal osteoporosis.
American journal of human genetics 2008;82(6):1262-9.
2008: Ana M Valdes; John Loughlin; Kirsten M Timms; Joyce J B van Meurs; Lorraine Southam; Scott G Wilson; Sally Doherty; Rik J Lories; Frank P Luyten; Alexander Gutin; Victor Abkevich; Dongliang Ge; Albert Hofman; André G Uitterlinden; Deborah J Hart; Feng Zhang; Guangju Zhai; Rainer Egli; Michael Doherty; Jerry S Lanchbury; Tim D Spector
Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.
American journal of human genetics 2008;82(6):1231-40.
2008: J B Richards; Fernando Rivadeneira; M Inouye; T M Pastinen; N Soranzo; S G Wilson; T Andrew; Mario Falchi; Rhian Gwilliam; K R Ahmadi; Ana M Valdes; P Arp; P Whittaker; D J Verlaan; M Jhamai; V Kumanduri; M Moorhouse; J B van Meurs; Albert Hofman; H A P Pols; D Hart; G Zhai; Bernet S Kato; B H Mullin; F Zhang; P Deloukas; André G Uitterlinden; Tim D Spector
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study.
Lancet 2008;371(9623):1505-12.
2008: Juliette M Harris; Lynn F Cherkas; Bernet S Kato; Julia R Heiman; Tim D Spector
Normal variations in personality are associated with coital orgasmic infrequency in heterosexual women: a population-based study.
The journal of sexual medicine 2008;5(5):1177-83.
2008: Mario Falchi; Scott G Wilson; Dimitrios Paximadas; Ramasamyiyer Swaminathan; Tim D Spector
Quantitative linkage analysis for pancreatic B-cell function and insulin resistance in a large twin cohort.
Diabetes 2008;57(4):1120-4.
2008: Chrysoula Dalageorgou; Dongliang Ge; Yalda Jamshidi; Ilja M Nolte; Harriëtte Riese; Irina Savelieva; Nicholas D Carter; Tim D Spector; Harold Snieder
Heritability of QT interval: how much is explained by genes for resting heart rate?
Journal of cardiovascular electrophysiology 2008;19(4):386-91.
2008: V Panicker; S G Wilson; Tim D Spector; S J Brown; M Falchi; J B Richards; G L Surdulescu; Ee Mun Lim; S J Fletcher; John P Walsh
Heritability of serum TSH, free T4 and free T3 concentrations: a study of a large UK twin cohort.
Clinical endocrinology 2008;68(4):652-9.
2008: Masayuki Kimura; Lynn F Cherkas; Bernet S Kato; Serkalem Demissie; Jacob B Hjelmborg; Michael Brimacombe; Adrienne Cupples; Janice L Hunkin; Jeffrey P Gardner; Xiaobin Lu; Xiaojian Cao; Malinee Sastrasinh; Michael A Province; Steven C Hunt; Kaare Christensen; Daniel Levy; Tim D Spector; Abraham Aviv
Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm.
PLoS genetics 2008;4(2):e37.
2008: Dongliang Ge; Sakina B Gooljar; Theodosios Kyriakou; Laura J Collins; Ramasamyiyer Swaminathan; Harold Snieder; Tim D Spector; Sandra D O'Dell
Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile.
Obesity (Silver Spring, Md.) 2008;16(2):492-6.
2008: Paula M L Skidmore; Aedin Cassidy; Ramasamyiyer Swaminathan; J Brent Richards; Tim D Spector; Alex J MacGregor
Relation of birth weight, body mass index, and change in size from birth to adulthood to insulin resistance in a female twin cohort.
The Journal of clinical endocrinology and metabolism 2008;93(2):516-20.
2008: Lynn F Cherkas; Janice L Hunkin; Bernet S Kato; J Brent Richards; Jeffrey P Gardner; Gabriela L Surdulescu; Masayuki Kimura; Xiaobin Lu; Tim D Spector; Abraham Aviv
The association between physical activity in leisure time and leukocyte telomere length.
Archives of internal medicine 2008;168(2):154-8.
2008: Tim D Spector; Mario Calomme; Simon H C Anderson; Gail Clement; Liisa Bevan; Nathalie Demeester; Rami Swaminathan; Ravin Jugdaohsingh; Dirk A Vanden Berghe; Jonathan J Powell
Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial.
BMC musculoskeletal disorders 2008;9():85.
2008: Theodosios Kyriakou; Laura J Collins; Nicola J Spencer-Jones; Claire Malcolm; Xiaoling Wang; Harold Snieder; Ramasamyiyer Swaminathan; Keith A Burling; Deborah J Hart; Tim D Spector; Sandra D O'Dell
Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.
Journal of human genetics 2008;53(8):718-27.
2008: Usha Chinappen-Horsley; Glen M Blake; Ignac Fogelman; Bernet S Kato; Kourosh R Ahmadi; Tim D Spector
Quantitative trait loci for bone lengths on chromosome 5 using dual energy X-Ray absorptiometry imaging in the Twins UK cohort.
PloS one 2008;3(3):e1752.
2008: Paul Healey; Francis Carbonaro; Bronwen Taylor; Tim D Spector; Paul Mitchell; Christopher J Hammond
The heritability of optic disc parameters: a classic twin study.
Investigative ophthalmology & visual science 2008;49(1):77-80.
2008: Frances M K Williams; Bernet S Kato; Gregory Livshits; P N Sambrook; Tim D Spector; Alex J MacGregor
Lumbar disc disease shows linkage to chromosome 19 overlapping with a QTL for hand OA.
Annals of the rheumatic diseases 2008;67(1):117-9.
2007: Julian Barwell; Laurent Pangon; Anne Georgiou; Zoe Docherty; Ian Kesterton; J Ball; Richard S Camplejohn; Jonathan Berg; Abraham Aviv; J Gardner; Bernet S Kato; N Carter; D Paximadas; Tim D Spector; Shirley Hodgson
Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?
British journal of cancer 2007;97(12):1696-700.
2007: M H M De Moor; Tim D Spector; Lynn F Cherkas; Mario Falchi; Jouke-Jan Hottenga; Dorret I Boomsma; Eco J C De Geus
Genome-wide linkage scan for athlete status in 700 British female DZ twin pairs.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2007;10(6):812-20.
2007: Guangju Zhai; Ana M Valdes; Lynn F Cherkas; Gail Clement; David Strachan; Tim D Spector
The interaction of genes and smoking on forced expiratory volume: a classic twin study.
Chest 2007;132(6):1772-7.
2007: Angela M Carter; Charlotte M Cymbalista; Tim D Spector; Peter J Grant
Heritability of clot formation, morphology, and lysis: the EuroCLOT study.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(12):2783-9.
2007: Stephan Menzel; Jie Jiang; Nicholas Silver; Joy Gallagher; Juliette Cunningham; Gabriela L Surdulescu; Mark Lathrop; Martin Farrall; Tim D Spector; Swee Lay Thein
The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.
Blood 2007;110(10):3624-6.
2007: J Brent Richards; Ana M Valdes; Jeffrey P Gardner; Dimitri Paximadas; Masayuki Kimura; Ayrun Nessa; Xiaobin Lu; Gabriela L Surdulescu; Rami Swaminathan; Tim D Spector; Abraham Aviv
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women.
The American journal of clinical nutrition 2007;86(5):1420-5.
2007: Timothy A Norbury; Alex J MacGregor; Jane Urwin; Tim D Spector; Stephen McMahon
Heritability of responses to painful stimuli in women: a classical twin study.
Brain : a journal of neurology 2007;130(Pt 11):3041-9.
2007: Birgit Teucher; Jane Skinner; Paula M L Skidmore; Aedin Cassidy; Susan J Fairweather-Tait; Lee Hooper; Mark A Roe; Robert J Foxall; Sarah L Oyston; Lynn F Cherkas; Ursula C Perks; Tim D Spector; Alex J MacGregor
Dietary patterns and heritability of food choice in a UK female twin cohort.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2007;10(5):734-48.
2007: Stephan Menzel; Chad Garner; Ivo Gut; Fumihiko MATSUDA; Masao Yamaguchi; Simon Heath; Mario Foglio; Diana Zelenika; Anne Boland; Helen Rooks; Steve Best; Tim D Spector; Martin Farrall; Mark Lathrop; Swee Lay Thein
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.
Nature genetics 2007;39(10):1197-9.
2007: Yalda Jamshidi; S B Gooljar; Harold Snieder; Xiaoling Wang; D Ge; R Swaminathan; Tim D Spector; Sandra D O'Dell
SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women.
Atherosclerosis 2007;194(2):e26-33.
2007: S H Melissa Liew; Clare E Gilbert; Tim D Spector; John Marshall; Christopher J Hammond
The role of heredity in determining central retinal thickness.
The British journal of ophthalmology 2007;91(9):1143-7.
2007: Ana M Valdes; J Brent Richards; Jeffrey P Gardner; R Swaminathan; Masayuki Kimura; L Xiaobin; Abraham Aviv; Tim D Spector
Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2007;18(9):1203-10.
2007: Gregory Livshits; Bernet S Kato; Scott G Wilson; Tim D Spector
Linkage of genes to total lean body mass in normal women.
The Journal of clinical endocrinology and metabolism 2007;92(8):3171-6.
2007: Swee Lay Thein; Stephan Menzel; Xu Peng; Steve Best; Jie Jiang; James Paul Close; Nicholas Silver; Ageliki Gerovasilli; Chen Ping; Masao Yamaguchi; Karin Wahlberg; Pinar Ulug; Tim D Spector; Chad Garner; Fumihiko MATSUDA; Martin Farrall; Mark Lathrop
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11346-51.
2007: Yalda Jamshidi; Theodosios Kyriakou; Sakina B Gooljar; Laura J Collins; Carl A Lane; Harold Snieder; Xiaoling Wang; Tim D Spector; Sandra D O'Dell
Common STAT3 variants are not associated with obesity or insulin resistance in female twins.
Obesity (Silver Spring, Md.) 2007;15(7):1634-9.
2007: Veronique Bataille; Bernet S Kato; Mario Falchi; Jeffrey Gardner; Masayuki Kimura; Marko Lens; Ursula Perks; Ana M Valdes; Dorothy C Bennett; Abraham Aviv; Tim D Spector
Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(7):1499-502.
2007: Feng Zhang; Bernet S Kato; Jeffrey P Gardner; Masayuki Kimura; Tim D Spector; Kourosh R Ahmadi
Lack of association between leukocyte telomere length and genetic variants in two ageing-related candidate genes.
Mechanisms of ageing and development 2007;128(7-8):415-22.
2007: Ben Mullin; Tim D Spector; C C Curtis; G N Ong; D J Hart; A J Hakim; T Worthy; Scott G Wilson
Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women.
Calcified tissue international 2007;81(1):10-7.
2007: Frances M K Williams; Nisha J Manek; P N Sambrook; Tim D Spector; Alex J MacGregor
Schmorl's nodes: common, highly heritable, and related to lumbar disc disease.
Arthritis and rheumatism 2007;57(5):855-60.
2007: Paul Healey; Paul Mitchell; Clare E Gilbert; Anne J Lee; Dongliang Ge; Harold Snieder; Tim D Spector; Christopher J Hammond
The inheritance of peripapillary atrophy.
Investigative ophthalmology & visual science 2007;48(6):2529-34.
2007: F Zhang; Guangju Zhai; Bernet S Kato; Deborah J Hart; David Hunter; Tim D Spector; Kourosh R Ahmadi
Association between KLOTHO gene and hand osteoarthritis in a female Caucasian population.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(6):624-9.
2007: Gregory Livshits; Bernet S Kato; Guangju Zhai; Deborah J Hart; David Hunter; Alex J MacGregor; Frances M K Williams; Tim D Spector
Genomewide linkage scan of hand osteoarthritis in female twin pairs showing replication of quantitative trait loci on chromosomes 2 and 19.
Annals of the rheumatic diseases 2007;66(5):623-7.
2007: Lynn F Cherkas; Frances M K Williams; Liisa Carter; K Howell; Carol M Black; Tim D Spector; Alex J MacGregor
Heritability of Raynaud's phenomenon and vascular responsiveness to cold: a study of adult female twins.
Arthritis and rheumatism 2007;57(3):524-8.
2007: J Brent Richards; Ana M Valdes; K Burling; Ursula Perks; Tim D Spector
Serum adiponectin and bone mineral density in women.
The Journal of clinical endocrinology and metabolism 2007;92(4):1517-23.
2007: Sophia Steer; Frances M K Williams; Bernet S Kato; Jeffry P Gardner; Paul J Norman; Margaret A Hall; Masayuki Kimura; Robert Vaughan; Abraham Aviv; Tim D Spector
Reduced telomere length in rheumatoid arthritis is independent of disease activity and duration.
Annals of the rheumatic diseases 2007;66(4):476-80.
2007: J Brent Richards; Lynn F Cherkas; Tim D Spector
An analysis of which anti-osteoporosis therapeutic regimen would improve compliance in a population of elderly adults.
Current medical research and opinion 2007;23(2):293-9.
2007: Guangju Zhai; Deborah J Hart; Bernet S Kato; A MacGregor; Tim D Spector
Genetic influence on the progression of radiographic knee osteoarthritis: a longitudinal twin study.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2007;15(2):222-5.
2007: Usha Chinappen-Horsley; Glen M Blake; Ignac Fogelman; Tim D Spector
A method for determining skeletal lengths from DXA images.
BMC musculoskeletal disorders 2007;8():113.
2007: Yalda Jamshidi; Harold Snieder; Dongliang Ge; Tim D Spector; Sandra D O'Dell
The SH2B gene is associated with serum leptin and body fat in normal female twins.
Obesity (Silver Spring, Md.) 2007;15(1):5-9.
2007: Ana M Valdes; John Loughlin; Mark Van Oene; Kay Chapman; Gabriela L Surdulescu; Michael Doherty; Tim D Spector
Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee.
Arthritis and rheumatism 2007;56(1):137-46.
2006: Tim D Spector; Frances M K Williams
The UK Adult Twin Registry (TwinsUK).
Twin research and human genetics : the official journal of the International Society for Twin Studies 2006;9(6):899-906.
2006: S N Paul; Bernet S Kato; J L Hunkin; S Vivekanandan; Tim D Spector
The big finger: the second to fourth digit ratio is a predictor of sporting ability in women.
British journal of sports medicine 2006;40(12):981-3.
2006: Abraham Aviv; Ana M Valdes; Tim D Spector
Human telomere biology: pitfalls of moving from the laboratory to epidemiology.
International journal of epidemiology 2006;35(6):1424-9.
2006: Caroline M Reavley; John F Golding; Lynn F Cherkas; Tim D Spector; Alex J MacGregor
Genetic influences on motion sickness susceptibility in adult women: a classical twin study.
Aviation, space, and environmental medicine 2006;77(11):1148-52.
2006: Clifton O Bingham; J Chris Buckland-Wright; Patrick Garnero; Stanley B Cohen; Maxime Dougados; Silvano Adami; Daniel J Clauw; Tim D Spector; Jean-Pierre Pelletier; Jean-Pierre Raynauld; Vibeke Strand; Lee S Simon; Joan M Meyer; Gary A Cline; John F Beary
Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study.
Arthritis and rheumatism 2006;54(11):3494-507.
2006: Guangju Zhai; Abraham Aviv; D J Hunter; Deborah J Hart; Jeffrey P Gardner; Masayuki Kimura; X Lu; Ana M Valdes; Tim D Spector
Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study.
Annals of the rheumatic diseases 2006;65(11):1444-8.
2006: Yalda Jamshidi; Harold Snieder; Xiaoling Wang; M J Pavitt; Tim D Spector; Nicholas D Carter; Sandra D O'Dell
Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population.
Diabetologia 2006;49(11):2659-67.
2006: Mario Falchi; Tim D Spector; Ursula Perks; Bernet S Kato; Veronique Bataille
Genome-wide search for nevus density shows linkage to two melanoma loci on chromosome 9 and identifies a new QTL on 5q31 in an adult twin cohort.
Human molecular genetics 2006;15(20):2975-9.
2006: Paula M L Skidmore; Aedin Cassidy; Ramasamyiyer Swaminathan; Mario Falchi; Tim D Spector; Alex J MacGregor
Intrauterine, environmental, and genetic influences in the relationship between birth weight and lipids in a female twin cohort.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(10):2373-9.
2006: Lynn F Cherkas; Abraham Aviv; Ana M Valdes; J L Hunkin; Jeffrey P Gardner; Gabriela L Surdulescu; Masayuki Kimura; Tim D Spector
The effects of social status on biological aging as measured by white-blood-cell telomere length.
Aging cell 2006;5(5):361-5.
2006: Richard S Camplejohn; Shirley Hodgson; N Carter; Bernet S Kato; Tim D Spector
Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins.
British journal of cancer 2006;95(4):520-4.
2006: Jie Jiang; Steve Best; Stephan Menzel; Nicholas Silver; Mei I Lai; Gabriela L Surdulescu; Tim D Spector; Swee Lay Thein
cMYB is involved in the regulation of fetal hemoglobin production in adults.
Blood 2006;108(3):1077-83.
2006: Marlies de Lange; Toby Andrew; Harold Snieder; Dongliang Ge; T Simon Futers; Kristina Standeven; Tim D Spector; Peter J Grant; Robert A S Ariëns
Joint linkage and association of six single-nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1914-9.
2006: Frances M K Williams; Toby Andrew; Tore Saxne; Dick Heinegård; Tim D Spector; Alex J MacGregor
The heritable determinants of cartilage oligomeric matrix protein.
Arthritis and rheumatism 2006;54(7):2147-51.
2006: S H Melissa Liew; Clare E Gilbert; Tim D Spector; John Mellerio; Frederik J G M van Kuijk; Stephen Beatty; Frederick W Fitzke; John Marshall; Christopher J Hammond
Central retinal thickness is positively correlated with macular pigment optical density.
Experimental eye research 2006;82(5):915-20.
2006: Geraldine Hassett; Deborah J Hart; David V Doyle; L March; Tim D Spector
The relation between progressive osteoarthritis of the knee and long term progression of osteoarthritis of the hand, hip, and lumbar spine.
Annals of the rheumatic diseases 2006;65(5):623-8.
2006: Simon N Paul; Bernet S Kato; Lynn F Cherkas; Toby Andrew; Tim D Spector
Heritability of the second to fourth digit ratio (2d:4d): A twin study.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2006;9(2):215-9.
2006: Toby Andrew; Abraham Aviv; Mario Falchi; Gabriela L Surdulescu; Jeffrey P Gardner; Xiaobin Lu; Masayuki Kimura; Bernet S Kato; Ana M Valdes; Tim D Spector
Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs.
American journal of human genetics 2006;78(3):480-6.
2006: Scott G Wilson; Gail Adam; Maria Langdown; Rikard Reneland; Andreas Braun; Toby Andrew; Gabriela L Surdulescu; Maria Norberg; Frank Dudbridge; Peter W Reed; Philip N Sambrook; Patrick W Kleyn; Tim D Spector
Linkage and potential association of obesity-related phenotypes with two genes on chromosome 12q24 in a female dizygous twin cohort.
European journal of human genetics : EJHG 2006;14(3):340-8.
2006: Ana M Valdes; Mark Van Oene; Deborah J Hart; Gabriela L Surdulescu; John Loughlin; Michael Doherty; Tim D Spector
Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women.
Arthritis and rheumatism 2006;54(2):533-9.
2006: Tim D Spector; Rikard Reneland; Steven Mah; Ana M Valdes; Deborah J Hart; Stefan Kammerer; Maria Langdown; Carolyn R Hoyal; Josephine Atienza; Michael Doherty; Proton Rahman; Matthew Nelson; Andreas Braun
Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling.
Arthritis and rheumatism 2006;54(2):524-32.
2006: Yalda Jamshidi; Harold Snieder; Xiaoling Wang; Tim D Spector; Nicholas D Carter; Sandra D O'Dell
Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins.
Diabetologia 2006;49(2):306-10.
2006: Abraham Aviv; Ana M Valdes; Jeffrey P Gardner; Rami Swaminathan; Masayuki Kimura; Tim D Spector
Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation.
The Journal of clinical endocrinology and metabolism 2006;91(2):635-40.
2006: Frances M K Williams; Tim D Spector
Recent advances in the genetics of osteoporosis.
Journal of musculoskeletal & neuronal interactions 2006;6(1):27-35.
2006: Jamie J Singer; Mario Falchi; Alex J MacGregor; Lynn F Cherkas; Tim D Spector
Genome-wide scan for prospective memory suggests linkage to chromosome 12q22.
Behavior genetics 2006;36(1):18-28.
2006: Chad Garner; Steve Best; Stephan Menzel; Helen Rooks; Tim D Spector; Swee Lay Thein
Two candidate genes for low platelet count identified in an Asian Indian kindred by genome-wide linkage analysis: glycoprotein IX and thrombopoietin.
European journal of human genetics : EJHG 2006;14(1):101-8.
2005: S H Melissa Liew; Clare E Gilbert; Tim D Spector; John Mellerio; John Marshall; Frederik J G M van Kuijk; Stephen Beatty; Frederick W Fitzke; Christopher J Hammond
Heritability of macular pigment: a twin study.
Investigative ophthalmology & visual science 2005;46(12):4430-6.
2005: Chad Garner; Stephan Menzel; C Martin; Nicholas Silver; Steve Best; Tim D Spector; Swee Lay Thein
Interaction between two quantitative trait loci affects fetal haemoglobin expression.
Annals of human genetics 2005;69(Pt 6):707-14.
2005: Ana M Valdes; Geraldine Hassett; Deborah J Hart; Tim D Spector
Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes: a candidate SNP association study in the Chingford cohort.
Spine 2005;30(21):2445-51.
2005: Nicola J Spencer-Jones; Xiaoling Wang; Harold Snieder; Tim D Spector; Nicholas D Carter; Sandra D O'Dell
Protein tyrosine phosphatase-1B gene PTPN1: selection of tagging single nucleotide polymorphisms and association with body fat, insulin sensitivity, and the metabolic syndrome in a normal female population.
Diabetes 2005;54(11):3296-304.
2005: Mario Falchi; Toby Andrew; Harold Snieder; Ramasamyiyer Swaminathan; Gabriela L Surdulescu; Tim D Spector
Identification of QTLs for serum lipid levels in a female sib-pair cohort: a novel application to improve the power of two-locus linkage analysis.
Human molecular genetics 2005;14(20):2971-9.
2005: Tze'Yo Toh; S H Melissa Liew; Jane R MacKinnon; Alex W Hewitt; Johan L Poulsen; Tim D Spector; Clare E Gilbert; Jamie E Craig; Christopher J Hammond; David A Mackey
Central corneal thickness is highly heritable: the twin eye studies.
Investigative ophthalmology & visual science 2005;46(10):3718-22.
2005: Ana M Valdes; Toby Andrew; Jeffrey P Gardner; M Kimura; E Oelsner; Lynn F Cherkas; Abraham Aviv; Tim D Spector
Obesity, cigarette smoking, and telomere length in women.
Lancet 2005;366(9486):662-4.
2005: S H Melissa Liew; Hanno Elsner; Tim D Spector; Christopher J Hammond
The first "classical" twin study? Analysis of refractive error using monozygotic and dizygotic twins published in 1922.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2005;8(3):198-200.
2005: Yuanneng Chen; Harold Snieder; Xiaoling Wang; Bhavini Kaviya; Clare McCaffrey; Tim D Spector; Nicholas D Carter; Sandra D O'Dell
Proopiomelanocortin gene variants are associated with serum leptin and body fat in a normal female population.
European journal of human genetics : EJHG 2005;13(6):772-80.
2005: Jamie J Singer; Alex J MacGregor; Lynn F Cherkas; Tim D Spector
Where did I leave my keys? A twin study of self-reported memory ratings using the multifactorial memory questionnaire.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2005;8(2):108-12.
2005: Rikard Reneland; Steven Mah; Stefan Kammerer; Carolyn R Hoyal; George Marnellos; Scott G Wilson; Philip N Sambrook; Tim D Spector; Matthew Nelson; Andreas Braun
Association between a variation in the phosphodiesterase 4D gene and bone mineral density.
BMC medical genetics 2005;6():9.
2005: Mandy Y M Ng; Toby Andrew; Tim D Spector; S Jeffery
Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs.
Journal of medical genetics 2005;42(3):235-9.
2005: Frances M K Williams; Lynn F Cherkas; Tim D Spector; Alex J MacGregor
The effect of moderate alcohol consumption on bone mineral density: a study of female twins.
Annals of the rheumatic diseases 2005;64(2):309-10.
2005: Tim D Spector; Philip Conaghan; J Chris Buckland-Wright; Patrick Garnero; Gary A Cline; John F Beary; David J Valent; Joan M Meyer
Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173].
Arthritis research & therapy 2005;7(3):R625-33.
2005: Toby Andrew; Leto Antioniades; Katrina J Scurrah; Alex J MacGregor; Tim D Spector
Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(1):67-74.
2004: Lynn F Cherkas; Elizabeth C Oelsner; Y T Mak; Ana M Valdes; Tim D Spector
Genetic influences on female infidelity and number of sexual partners in humans: a linkage and association study of the role of the vasopressin receptor gene (AVPR1A).
Twin research : the official journal of the International Society for Twin Studies 2004;7(6):649-58.
2004: Marlies de Lange; Tim D Spector; Toby Andrew
Genome-wide scan for blood pressure suggests linkage to chromosome 11, and replication of loci on 16, 17, and 22.
Hypertension 2004;44(6):872-7.
2004: Frances M K Williams; Lynn F Cherkas; Tim D Spector; Alex J MacGregor
A common genetic factor underlies hypertension and other cardiovascular disorders.
BMC cardiovascular disorders 2004;4(1):20.
2004: Chad Garner; Nicholas Silver; Steve Best; Stephan Menzel; Charlotte Martin; Tim D Spector; Swee Lay Thein
Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin.
Blood 2004;104(7):2184-6.
2004: Alan J Hakim; Lynn F Cherkas; Rodney Grahame; Tim D Spector; Alex J MacGregor
The genetic epidemiology of joint hypermobility: a population study of female twins.
Arthritis and rheumatism 2004;50(8):2640-4.
2004: Ana M Valdes; Deborah J Hart; Karen A Jones; Gabriela L Surdulescu; Peter Swarbrick; David V Doyle; Alan J Schafer; Tim D Spector
Association study of candidate genes for the prevalence and progression of knee osteoarthritis.
Arthritis and rheumatism 2004;50(8):2497-507.
2004: Christopher J Hammond; Toby Andrew; Ying T Mak; Tim D Spector
A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins.
American journal of human genetics 2004;75(2):294-304.
2004: Ying T Mak; Geeta Hampson; Jon N Beresford; Tim D Spector
Variations in genome-wide gene expression in identical twins - a study of primary osteoblast-like culture from female twins discordant for osteoporosis.
BMC genetics 2004;5():14.
2004: Karen M Knapp; Glen M Blake; Tim D Spector; Ignac Fogelman
Can the WHO definition of osteoporosis be applied to multi-site axial transmission quantitative ultrasound?
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2004;15(5):367-74.
2004: Alex J MacGregor; Toby Andrew; Philip N Sambrook; Tim D Spector
Structural, psychological, and genetic influences on low back and neck pain: a study of adult female twins.
Arthritis and rheumatism 2004;51(2):160-7.
2004: Emma J Dunn; Robert A S Ariëns; Marlies de Lange; Harold Snieder; John H Turney; Tim D Spector; Peter J Grant
Genetics of fibrin clot structure: a twin study.
Blood 2004;103(5):1735-40.
2004: Scott G Wilson; Peter W Reed; Toby Andrew; Mathew Barber; M Lindersson; Maria Langdown; D Thompson; E Thompson; M Bailey; M Chiano; Patrick W Kleyn; Tim D Spector
A genome-screen of a large twin cohort reveals linkage for quantitative ultrasound of the calcaneus to 2q33-37 and 4q12-21.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(2):270-7.
2004: Tim D Spector; Alex J MacGregor
Risk factors for osteoarthritis: genetics.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12 Suppl A():S39-44.
2004: Alex J MacGregor; J Ruth Gallimore; Tim D Spector; Mark B Pepys
Genetic effects on baseline values of C-reactive protein and serum amyloid a protein: a comparison of monozygotic and dizygotic twins.
Clinical chemistry 2004;50(1):130-4.
2003: Geraldine Hassett; Deborah J Hart; N J Manek; David V Doyle; Tim D Spector
Risk factors for progression of lumbar spine disc degeneration: the Chingford Study.
Arthritis and rheumatism 2003;48(11):3112-7.
2003: Karen M Knapp; Toby Andrew; Alex J MacGregor; Glen M Blake; Ignac Fogelman; Tim D Spector
An investigation of unique and shared gene effects on speed of sound and bone density using axial transmission quantitative ultrasound and DXA in twins.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(8):1525-30.
2003: Kourosh R Ahmadi; Jerry S Lanchbury; P Reed; M Chiano; D Thompson; M Galley; A Line; E Lank; H J Wong; D Strachan; Tim D Spector
Novel association suggests multiple independent QTLs within chromosome 5q21-33 region control variation in total humans IgE levels.
Genes and immunity 2003;4(4):289-97.
2003: Karen M Knapp; Glen M Blake; Tim D Spector; Ignac Fogelman
Differential effects of hormone replacement therapy on bone mineral density and axial transmission ultrasound measurements in cortical bone.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2003;14(4):289-94.
2003: L Antoniades; Alex J MacGregor; Toby Andrew; Tim D Spector
Association of birth weight with osteoporosis and osteoarthritis in adult twins.
Rheumatology (Oxford, England) 2003;42(6):791-6.
2003: Alan J Hakim; Lynn F Cherkas; Tim D Spector; Alex J MacGregor
Genetic associations between frozen shoulder and tennis elbow: a female twin study.
Rheumatology (Oxford, England) 2003;42(6):739-42.
2003: Marlies de Lange; Harold Snieder; Robert A S Ariëns; Toby Andrew; Peter J Grant; Tim D Spector
The relation between insulin resistance and hemostasis: pleiotropic genes and common environment.
Twin research : the official journal of the International Society for Twin Studies 2003;6(2):152-61.
2003: Nisha J Manek; Deborah Hart; Tim D Spector; Alex J MacGregor
The association of body mass index and osteoarthritis of the knee joint: an examination of genetic and environmental influences.
Arthritis and rheumatism 2003;48(4):1024-9.
2003: A Louise Dolan; Deborah J Hart; David V Doyle; Rodney Grahame; Tim D Spector
The relationship of joint hypermobility, bone mineral density, and osteoarthritis in the general population: the Chingford Study.
The Journal of rheumatology 2003;30(4):799-803.
2003: Lynn F Cherkas; Liisa Carter; Tim D Spector; Kevin J Howell; Carol M Black; Alex J MacGregor
Use of thermographic criteria to identify Raynaud's phenomenon in a population setting.
The Journal of rheumatology 2003;30(4):720-2.
2003: D J Hart; Tim D Spector
Kellgren & Lawrence grade 1 osteophytes in the knee--doubtful or definite?
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(2):149-50.
2003: Scott G Wilson; Peter W Reed; A Bansal; M Chiano; M Lindersson; Maria Langdown; Richard L Prince; D Thompson; E Thompson; M Bailey; Patrick W Kleyn; P Sambrook; M M Shi; Tim D Spector
Comparison of genome screens for two independent cohorts provides replication of suggestive linkage of bone mineral density to 3p21 and 1p36.
American journal of human genetics 2003;72(1):144-55.
2002: Veronique Bataille; Harold Snieder; Alex J MacGregor; Peter Sasieni; Tim D Spector
The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women.
The Journal of investigative dermatology 2002;119(6):1317-22.
2002: Tim D Spector; Alex J MacGregor
The St. Thomas' UK Adult Twin Registry.
Twin research : the official journal of the International Society for Twin Studies 2002;5(5):440-3.
2002: Ken-ichi Kawano; Naoshi Ogata; Mathias Chiano; Helen Molloy; Patrick W Kleyn; Tim D Spector; Motoyuki Uchida; Takayuki Hosoi; Takao Suzuki; Hajime Orimo; Satoshi Inoue; Yo-ichi Nabeshima; Kozo Nakamura; Makoto Kuro-o; Hiroshi Kawaguchi
Klotho gene polymorphisms associated with bone density of aged postmenopausal women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(10):1744-51.
2002: Toby Andrew; Ying T Mak; P Reed; Alex J MacGregor; Tim D Spector
Linkage and association for bone mineral density and heel ultrasound measurements with a simple tandem repeat polymorphism near the osteocalcin gene in female dizygotic twins.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2002;13(9):745-54.
2002: David J Hunter; Marlies de Lange; Harold Snieder; Alex J MacGregor; Ramasamyiyer Swaminathan; Rajesh V Thakker; Tim D Spector
Genetic contribution to renal function and electrolyte balance: a twin study.
Clinical science (London, England : 1979) 2002;103(3):259-65.
2002: Rita P S Middelberg; Tim D Spector; Ramasamyiyer Swaminathan; Harold Snieder
Genetic and environmental influences on lipids, lipoproteins, and apolipoproteins: effects of menopause.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(7):1142-7.
2002: Alan J Hakim; Lynn F Cherkas; Sameh El Zayat; Alex J MacGregor; Tim D Spector
The genetic contribution to carpal tunnel syndrome in women: a twin study.
Arthritis and rheumatism 2002;47(3):275-9.
2002: Christopher J Hammond; Andrew R Webster; Harold Snieder; Alan C Bird; Clare E Gilbert; Tim D Spector
Genetic influence on early age-related maculopathy: a twin study.
Ophthalmology 2002;109(4):730-6.
2002: Robert A S Ariëns; Marlies de Lange; Harold Snieder; May Boothby; Tim D Spector; Peter J Grant
Activation markers of coagulation and fibrinolysis in twins: heritability of the prethrombotic state.
Lancet 2002;359(9307):667-71.
2002: Karen M Knapp; Glen M Blake; Ignac Fogelman; D V Doyle; Tim D Spector
Multisite quantitative ultrasound: Colles' fracture discrimination in postmenopausal women.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2002;13(6):474-9.
2002: Deborah J Hart; Camille Cronin; Maxine Daniels; Tina Worthy; David V Doyle; Tim D Spector
The relationship of bone density and fracture to incident and progressive radiographic osteoarthritis of the knee: the Chingford Study.
Arthritis and rheumatism 2002;46(1):92-9.
2001: Toby Andrew; D J Hart; Harold Snieder; Marlies de Lange; Tim D Spector; Alex J MacGregor
Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women.
Twin research : the official journal of the International Society for Twin Studies 2001;4(6):464-77.
2001: Harold Snieder; P A Sawtell; L Ross; J Walker; Tim D Spector; richard leslie
HbA(1c) levels are genetically determined even in type 1 diabetes: evidence from healthy and diabetic twins.
Diabetes 2001;50(12):2858-63.
2001: Kourosh R Ahmadi; MA Hall; P Norman; Robert W Vaughan; Harold Snieder; Tim D Spector; Jerry S Lanchbury
Genetic determinism in the relationship between human CD4+ and CD8+ T lymphocyte populations?
Genes and immunity 2001;2(7):381-7.
2001: L Antoniades; Tim D Spector; Alex J MacGregor
The genetic contribution to hip joint morphometry and relationship to hip cartilage thickness.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(6):593-5.
2001: Christopher J Hammond; Harold Snieder; Clare E Gilbert; Tim D Spector
Genes and environment in refractive error: the twin eye study.
Investigative ophthalmology & visual science 2001;42(6):1232-6.
2001: Christopher J Hammond; Donald D Duncan; Harold Snieder; Marlies de Lange; Sheila K West; Tim D Spector; Clare E Gilbert
The heritability of age-related cortical cataract: the twin eye study.
Investigative ophthalmology & visual science 2001;42(3):601-5.
2001: David Hunter; Marlies de Lange; Harold Snieder; Alex J MacGregor; Ramasamyiyer Swaminathan; Rajesh V Thakker; Tim D Spector
Genetic contribution to bone metabolism, calcium excretion, and vitamin D and parathyroid hormone regulation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(2):371-8.
2001: Marlies de Lange; Harold Snieder; Robert A S Ariëns; Tim D Spector; Peter J Grant
The genetics of haemostasis: a twin study.
Lancet 2001;357(9250):101-5.
2001: Karen M Knapp; Glen M Blake; Tim D Spector; Ignac Fogelman
Multisite quantitative ultrasound: precision, age- and menopause-related changes, fracture discrimination, and T-score equivalence with dual-energy X-ray absorptiometry.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2001;12(6):456-64.
2001: D J Hunter; Marlies de Lange; Toby Andrew; Harold Snieder; Alex J MacGregor; Tim D Spector
Genetic variation in bone mineral density and calcaneal ultrasound: a study of the influence of menopause using female twins.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2001;12(5):406-11.
2001: RW Keen; Harold Snieder; H Molloy; J Daniels; M Chiano; F Gibson; L Fairbairn; P Smith; A J MacGregor; D Gewert; Tim D Spector
Evidence of association and linkage disequilibrium between a novel polymorphism in the transforming growth factor beta 1 gene and hip bone mineral density: a study of female twins.
Rheumatology (Oxford, England) 2001;40(1):48-54.
2000: David Hunter; P Major; Nigel K Arden; Ramasamyiyer Swaminathan; Toby Andrew; Alex J MacGregor; RW Keen; Harold Snieder; Tim D Spector
A randomized controlled trial of vitamin D supplementation on preventing postmenopausal bone loss and modifying bone metabolism using identical twin pairs.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(11):2276-83.
2000: Alex J MacGregor; L Antoniades; Matthew Matson; Toby Andrew; Tim D Spector
The genetic contribution to radiographic hip osteoarthritis in women: results of a classic twin study.
Arthritis and rheumatism 2000;43(11):2410-6.
2000: MA Hall; Kourosh R Ahmadi; P Norman; Harold Snieder; A J MacGregor; Robert W Vaughan; Tim D Spector; Jerry S Lanchbury
Genetic influence on peripheral blood T lymphocyte levels.
Genes and immunity 2000;1(7):423-7.
2000: Christopher J Hammond; Harold Snieder; Tim D Spector; Clare E Gilbert
Factors affecting pupil size after dilatation: the Twin Eye Study.
The British journal of ophthalmology 2000;84(10):1173-6.
2000: L Antoniades; Alex J MacGregor; Matthew Matson; Tim D Spector
A cotwin control study of the relationship between hip osteoarthritis and bone mineral density.
Arthritis and rheumatism 2000;43(7):1450-5.
2000: Christopher J Hammond; Harold Snieder; Tim D Spector; Clare E Gilbert
Genetic and environmental factors in age-related nuclear cataracts in monozygotic and dizygotic twins.
The New England journal of medicine 2000;342(24):1786-90.
2000: Lynn F Cherkas; F Hochberg; Alex J MacGregor; Harold Snieder; Tim D Spector
Happy families: a twin study of humour.
Twin research : the official journal of the International Society for Twin Studies 2000;3(1):17-22.
2000: Alex J MacGregor; Harold Snieder; N J Schork; Tim D Spector
Twins. Novel uses to study complex traits and genetic diseases.
Trends in genetics : TIG 2000;16(3):131-4.
2000: Harold Snieder; Christopher S Hayward; Ursula Perks; RP Kelly; P J Kelly; Tim D Spector
Heritability of central systolic pressure augmentation: a twin study.
Hypertension 2000;35(2):574-9.
2000: Deborah J Hart; Tim D Spector
Definition and epidemiology of osteoarthritis of the hand: a review.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2000;8 Suppl A():S2-7.
1999: Philip N Sambrook; A J MacGregor; Tim D Spector
Genetic influences on cervical and lumbar disc degeneration: a magnetic resonance imaging study in twins.
Arthritis and rheumatism 1999;42(2):366-72.
1999: RW Keen; K L Woodford-Richens; S F Grant; S H Ralston; JS Lanchbury; Tim D Spector
Association of polymorphism at the type I collagen (COL1A1) locus with reduced bone mineral density, increased fracture risk, and increased collagen turnover.
Arthritis and rheumatism 1999;42(2):285-90.
1999: R W Keen; Deborah J Hart; Nigel K Arden; David V Doyle; Tim D Spector
Family history of appendicular fracture and risk of osteoporosis: a population-based study.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1999;10(2):161-6.
1999: G H George; Alex J MacGregor; Tim D Spector
Influence of current and past hormone replacement therapy on bone mineral density: a study of discordant postmenopausal twins.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1999;9(2):158-62.
1999: Deborah J Hart; David V Doyle; Tim D Spector
Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study.
Arthritis and rheumatism 1999;42(1):17-24.
1998: A Louise Dolan; N K Arden; Rodney Grahame; Tim D Spector
Assessment of bone in Ehlers Danlos syndrome by ultrasound and densitometry.
Annals of the rheumatic diseases 1998;57(10):630-3.
1998: RW Keen; K L Woodford-Richens; JS Lanchbury; Tim D Spector
Allelic variation at the interleukin-1 receptor antagonist gene is associated with early postmenopausal bone loss at the spine.
Bone 1998;23(4):367-71.
1998: T Masud; B Mulcahy; A V Thompson; S Donnelly; R W Keen; David V Doyle; Tim D Spector
Effects of cyclical etidronate combined with calcitriol versus cyclical etidronate alone on spine and femoral neck bone mineral density in postmenopausal osteoporotic women.
Annals of the rheumatic diseases 1998;57(6):346-9.
1997: Flavia M Cicuttini; Tim D Spector
What is the evidence that osteoarthritis is genetically determined?
Baillière's clinical rheumatology 1997;11(4):657-69.
1997: RW Keen; Deborah J Hart; JS Lanchbury; Tim D Spector
Association of early osteoarthritis of the knee with a Taq I polymorphism of the vitamin D receptor gene.
Arthritis and rheumatism 1997;40(8):1444-9.
1997: Tim D Spector; D Nandra; Deborah J Hart; David V Doyle
Is hormone replacement therapy protective for hand and knee osteoarthritis in women?: The Chingford Study.
Annals of the rheumatic diseases 1997;56(7):432-4.
1997: Tim D Spector; Deborah J Hart; D Nandra; David V Doyle; N Mackillop; J R Gallimore; M B Pepys
Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease.
Arthritis and rheumatism 1997;40(4):723-7.
1997: RW Keen; P Egger; Caroline H D Fall; P J Major; JS Lanchbury; Tim D Spector; Cyrus Cooper
Polymorphisms of the vitamin D receptor, infant growth, and adult bone mass.
Calcified tissue international 1997;60(3):233-5.
1996: M E Lloyd; Deborah J Hart; D Nandra; T E McAlindon; M Wheeler; David V Doyle; Tim D Spector
Relation between insulin-like growth factor-I concentrations, osteoarthritis, bone density, and fractures in the general population: the Chingford study.
Annals of the rheumatic diseases 1996;55(12):870-4.
1996: N K Arden; G O Griffiths; Deborah J Hart; David V Doyle; Tim D Spector
The association between osteoarthritis and osteoporotic fracture: the Chingford Study.
British journal of rheumatology 1996;35(12):1299-304.
1996: Cyrus Cooper; P Egger; David Coggon; Deborah J Hart; T Masud; Flavia M Cicuttini; David V Doyle; Tim D Spector
Generalized osteoarthritis in women: pattern of joint involvement and approaches to definition for epidemiological studies.
The Journal of rheumatology 1996;23(11):1938-42.
1996: Flavia M Cicuttini; Tim D Spector
Genetics of osteoarthritis.
Annals of the rheumatic diseases 1996;55(9):665-7.
1996: J Etherington; P A Harris; D Nandra; Deborah J Hart; R L Wolman; David V Doyle; Tim D Spector
The effect of weight-bearing exercise on bone mineral density: a study of female ex-elite athletes and the general population.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(9):1333-8.
1996: F M Cicuttini; J R Baker; Tim D Spector
The association of obesity with osteoarthritis of the hand and knee in women: a twin study.
The Journal of rheumatology 1996;23(7):1221-6.
1996: Flavia M Cicuttini; J Baker; Deborah J Hart; Tim D Spector
Association of pain with radiological changes in different compartments and views of the knee joint.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1996;4(2):143-7.
1996: G M Hall; J P Larbre; Tim D Spector; L A Perry; J A Da Silva
A randomized trial of testosterone therapy in males with rheumatoid arthritis.
British journal of rheumatology 1996;35(6):568-73.
1996: Tim D Spector; P A Harris; Deborah J Hart; Flavia M Cicuttini; D Nandra; J Etherington; R L Wolman; David V Doyle
Risk of osteoarthritis associated with long-term weight-bearing sports: a radiologic survey of the hips and knees in female ex-athletes and population controls.
Arthritis and rheumatism 1996;39(6):988-95.
1996: T Masud; I Mootoosamy; E V McCloskey; M P O'Sullivan; E P Whitby; D King; Matthew Matson; David V Doyle; Tim D Spector
Assessment of osteopenia from spine radiographs using two different methods: the Chingford Study.
The British journal of radiology 1996;69(821):451-6.
1996: Tim D Spector; F Cicuttini; J Baker; J Loughlin; D Hart
Genetic influences on osteoarthritis in women: a twin study.
BMJ (Clinical research ed.) 1996;312(7036):940-3.
1996: N K Arden; J Baker; C Hogg; K Baan; Tim D Spector
The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(4):530-4.
1996: Flavia M Cicuttini; J Baker; Deborah J Hart; Tim D Spector
Choosing the best method for radiological assessment of patellofemoral osteoarthritis.
Annals of the rheumatic diseases 1996;55(2):134-6.
1996: S Donnelly; Deborah J Hart; David V Doyle; Tim D Spector
Spiking of the tibial tubercles--a radiological feature of osteoarthritis?
Annals of the rheumatic diseases 1996;55(2):105-8.
1996: RW Keen; T Nguyen; R Sobnack; L A Perry; P W Thompson; Tim D Spector
Can biochemical markers predict bone loss at the hip and spine?: a 4-year prospective study of 141 early postmenopausal women.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1996;6(5):399-406.
1996: N K Arden; RW Keen; JS Lanchbury; Tim D Spector
Polymorphisms of the vitamin D receptor gene do not predict quantitative ultrasound of the calcaneus or hip axis length.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 1996;6(4):334-7.
1995: P Egger; Cyrus Cooper; Deborah J Hart; David V Doyle; David Coggon; Tim D Spector
Patterns of joint involvement in osteoarthritis of the hand: the Chingford Study.
The Journal of rheumatology 1995;22(8):1509-13.
1995: G M Hall; Tim D Spector; P D Delmas
Markers of bone metabolism in postmenopausal women with rheumatoid arthritis. Effects of corticosteroids and hormone replacement therapy.
Arthritis and rheumatism 1995;38(7):902-6.
1995: Flavia M Cicuttini; Tim D Spector
The epidemiology of osteoarthritis of the hand.
Revue du rhumatisme (English ed.) 1995;62(6 Suppl 1):3S-8S.
1995: Tim D Spector; RW Keen; N K Arden; N A Morrison; P J Major; Tuan V Nguyen; P J Kelly; J R Baker; Philip N Sambrook; JS Lanchbury
Influence of vitamin D receptor genotype on bone mineral density in postmenopausal women: a twin study in Britain.
BMJ (Clinical research ed.) 1995;310(6991):1357-60.
1995: Deborah J Hart; Tim D Spector
The classification and assessment of osteoarthritis.
Baillière's clinical rheumatology 1995;9(2):407-32.
1995: F M Cicuttini; Tim D Spector
Osteoarthritis in the aged. Epidemiological issues and optimal management.
Drugs & aging 1995;6(5):409-20.
1995: RW Keen; P J Major; JS Lanchbury; Tim D Spector
Vitamin-D-receptor-gene polymorphism and bone loss.
Lancet 1995;345(8955):990.
1995: T Masud; S Jawed; David V Doyle; Tim D Spector
A population study of the screening potential of assessment of trabecular pattern of the femoral neck (Singh index): the Chingford Study.
The British journal of radiology 1995;68(808):389-93.
1994: P A Harris; Deborah J Hart; J E Dacre; E C Huskisson; Tim D Spector
The progression of radiological hand osteoarthritis over ten years: a clinical follow-up study.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1994;2(4):247-52.
1994: Tim D Spector; Deborah J Hart; David V Doyle
Incidence and progression of osteoarthritis in women with unilateral knee disease in the general population: the effect of obesity.
Annals of the rheumatic diseases 1994;53(9):565-8.
1994: Deborah J Hart; I Mootoosamy; David V Doyle; Tim D Spector
The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study.
Annals of the rheumatic diseases 1994;53(3):158-62.
1994: Tim D Spector; Marc C Hochberg
Methodological problems in the epidemiological study of osteoarthritis.
Annals of the rheumatic diseases 1994;53(2):143-6.
1994: S Donnelly; David V Doyle; A Denton; I Rolfe; E V McCloskey; Tim D Spector
Bone mineral density and vertebral compression fracture rates in ankylosing spondylitis.
Annals of the rheumatic diseases 1994;53(2):117-21.
1994: G M Hall; M Daniels; E C Huskisson; Tim D Spector
A randomised controlled trial of the effect of hormone replacement therapy on disease activity in postmenopausal rheumatoid arthritis.
Annals of the rheumatic diseases 1994;53(2):112-6.
1994: N K Arden; M E Lloyd; Tim D Spector; G R Hughes
Safety of hormone replacement therapy (HRT) in systemic lupus erythematosus (SLE).
Lupus 1994;3(1):11-3.
1993: N K Arden; Tim D Spector
Oestrogens, bones and systemic lupus erythematosus.
Lupus 1993;2(6):381-2.
1993: Tim D Spector; Deborah J Hart; J Byrne; P A Harris; J E Dacre; David V Doyle
Definition of osteoarthritis of the knee for epidemiological studies.
Annals of the rheumatic diseases 1993;52(11):790-4.
1993: G M Hall; Tim D Spector; A J Griffin; A S Jawad; M L Hall; David V Doyle
The effect of rheumatoid arthritis and steroid therapy on bone density in postmenopausal women.
Arthritis and rheumatism 1993;36(11):1510-6.
1993: T Masud; S Langley; P Wiltshire; David V Doyle; Tim D Spector
Effect of spinal osteophytosis on bone mineral density measurements in vertebral osteoporosis.
BMJ (Clinical research ed.) 1993;307(6897):172-3.
1993: Tim D Spector; E V McCloskey; David V Doyle; John A Kanis
Prevalence of vertebral fracture in women and the relationship with bone density and symptoms: the Chingford Study.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(7):817-22.
1993: J A da Silva; Paul Colville-Nash; Tim D Spector; David Scott; Derek A Willoughby
Inflammation-induced cartilage degradation in female rodents. Protective role of sex hormones.
Arthritis and rheumatism 1993;36(7):1007-13.
1993: Tim D Spector; I T James; G M Hall; P W Thompson; D Perrett; D J Hart
Increased levels of urinary collagen crosslinks in females with rheumatoid arthritis.
Clinical rheumatology 1993;12(2):240-4.
1993: J A Da Silva; J P Larbre; Tim D Spector; L A Perry; David Scott; Derek A Willoughby
Protective effect of androgens against inflammation induced cartilage degradation in male rodents.
Annals of the rheumatic diseases 1993;52(4):285-91.
1993: G M Hall; L A Perry; Tim D Spector
Depressed levels of dehydroepiandrosterone sulphate in postmenopausal women with rheumatoid arthritis but no relation with axial bone density.
Annals of the rheumatic diseases 1993;52(3):211-4.
1993: Tim D Spector
Epidemiology of the rheumatic diseases.
Current opinion in rheumatology 1993;5(2):132-7.
1993: Tim D Spector; G M Hall; E V McCloskey; John A Kanis
Risk of vertebral fracture in women with rheumatoid arthritis.
BMJ (Clinical research ed.) 1993;306(6877):558.
1993: Deborah J Hart; Tim D Spector
The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study.
The Journal of rheumatology 1993;20(2):331-5.
1993: D J Hart; Tim D Spector
Cigarette smoking and risk of osteoarthritis in women in the general population: the Chingford study.
Annals of the rheumatic diseases 1993;52(2):93-6.
1992: P W Thompson; Tim D Spector; I T James; E Henderson; D J Hart
Urinary collagen crosslinks reflect the radiographic severity of knee osteoarthritis.
British journal of rheumatology 1992;31(11):759-61.
1992: Tim D Spector; L Woodward; G M Hall; A Hammond; A Williams; M G Butler; I T James; D J Hart; P W Thompson; David Scott
Keratan sulphate in rheumatoid arthritis, osteoarthritis, and inflammatory diseases.
Annals of the rheumatic diseases 1992;51(10):1134-7.
1992: Tim D Spector; J E Dacre; P A Harris; E C Huskisson
Radiological progression of osteoarthritis: an 11 year follow up study of the knee.
Annals of the rheumatic diseases 1992;51(10):1107-10.
1992: Tim D Spector; D J Hart
How serious is knee osteoarthritis?
Annals of the rheumatic diseases 1992;51(10):1105-6.
1992: Tim D Spector; J A Da Silva
Pregnancy and rheumatoid arthritis: an overview.
American journal of reproductive immunology (New York, N.Y. : 1989) 1992;28(3-4):222-5.
1992: J A Da Silva; Tim D Spector
The role of pregnancy in the course and aetiology of rheumatoid arthritis.
Clinical rheumatology 1992;11(2):189-94.
1991: Tim D Spector; Deborah J Hart; P Brown; J Almeyda; J E Dacre; David V Doyle; A J Silman
Frequency of osteoarthritis in hysterectomized women.
The Journal of rheumatology 1991;18(12):1877-83.
1991: Tim D Spector; P Brennan; P Harris; J W Studd; A J Silman
Does estrogen replacement therapy protect against rheumatoid arthritis?
The Journal of rheumatology 1991;18(10):1473-6.
1991: Deborah J Hart; Tim D Spector; P Brown; P Wilson; David V Doyle; A J Silman
Clinical signs of early osteoarthritis: reproducibility and relation to x ray changes in 541 women in the general population.
Annals of the rheumatic diseases 1991;50(7):467-70.
1991: C L Chander; Tim D Spector
Oestrogens, joint disease, and cartilage.
Annals of the rheumatic diseases 1991;50(3):139-40.
1991: Tim D Spector; P W Thompson; L A Perry; H H McGarrigle; A C Edwards
The relationship between sex steroids and bone mineral content in women soon after the menopause.
Clinical endocrinology 1991;34(1):37-41.
1990: Tim D Spector
The fat on the joint: osteoarthritis and obesity.
The Journal of rheumatology 1990;17(3):283-4.
1990: Tim D Spector; A J Silman
Is poor pregnancy outcome a risk factor in rheumatoid arthritis?
Annals of the rheumatic diseases 1990;49(1):12-4.
1989: Tim D Spector; G D Campion
Generalised osteoarthritis: a hormonally mediated disease.
Annals of the rheumatic diseases 1989;48(6):523-7.
1989: Tim D Spector; W Ollier; L A Perry; A J Silman; P W Thompson; A Edwards
Free and serum testosterone levels in 276 males: a comparative study of rheumatoid arthritis, ankylosing spondylitis and healthy controls.
Clinical rheumatology 1989;8(1):37-41.
1989: David Scott; Tim D Spector; T Pullar; B McConkey
What should we hope to achieve when treating rheumatoid arthritis?
Annals of the rheumatic diseases 1989;48(3):256-61.
1989: Tim D Spector
Sex hormone measurements in rheumatoid arthritis.
British journal of rheumatology 1989;28 Suppl 1():62-8; discussion 69-71.
1988: Tim D Spector; David Scott
What happens to patients with rheumatoid arthritis? The long-term outcome of treatment.
Clinical rheumatology 1988;7(3):315-30.