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Ernst Speel

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Jeroen J Mooren; J Peter Klussmann; Frans C S Ramaekers; Fredrik J Bot; S M H Claessen; Anton H N Hopman; Christian U Huebbers; Bernd Kremer; Adri C Voogd; Ernst J M Speel
Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis.
Jos M J A A Straetmans; Ernst J M Speel; Bernd Kremer
Value of human papillomavirus testing in the diagnostic workup of lymph node metastases from an unknown primary tumor to the neck.
Nadine C Olthof; Frans C S Ramaekers; Robert Snoeck; Bernd Kremer; Jos M J A A Straetmans; Ernst J M Speel
Next-generation treatment strategies for human papillomavirus-related head and neck squamous cell carcinoma: where do we go?

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All Publications

2013: Jeroen J Mooren; J Peter Klussmann; Frans C S Ramaekers; Fredrik J Bot; S M H Claessen; Anton H N Hopman; Christian U Huebbers; Bernd Kremer; Adri C Voogd; Ernst J M Speel
Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis.
International journal of cancer. Journal international du cancer 2013;132(8):1781-9.
2012: Jos M J A A Straetmans; Ernst J M Speel; Bernd Kremer
Value of human papillomavirus testing in the diagnostic workup of lymph node metastases from an unknown primary tumor to the neck.
Head & neck 2012;34(12):1819-20; author reply 1820-1.
2012: Nadine C Olthof; Frans C S Ramaekers; Robert Snoeck; Bernd Kremer; Jos M J A A Straetmans; Ernst J M Speel
Next-generation treatment strategies for human papillomavirus-related head and neck squamous cell carcinoma: where do we go?
Reviews in medical virology 2012;22(2):88-105.
2011: Dorian R A Swarts; Frederik B J M Thunnissen; Robert-Jan van Suylen; Aryan Vink; S M H Claessen; Wouter W de Herder; Ronald R de Krijger; Anne-Marie C Dingemans; Y M H Jonkers; Aurel Perren; Frans C S Ramaekers; Cornelis A Seldenrijk; Egbert F Smit; Ernst J M Speel
Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and poor clinical outcome.
The American journal of pathology 2011;179(3):1129-37.
2011: Stijn A J H M Fleskens; Bernd Kremer; Verona E Bergshoeff; Fredrik J Bot; Ernst J M Speel; Robert Takes; Marie-Louise F Van Velthuysen; Adri C Voogd; Piet Slootweg
Interobserver variability of laryngeal mucosal premalignant lesions: a histopathological evaluation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011;24(7):892-8.
2011: Markus Stenner; Basima Yosef; Hans-Peter Dienes; Christian U Huebbers; Margarete Odenthal; Simon Florian Preuss; Ernst J M Speel; Jens Peter Klussmann
Nuclear translocation of β-catenin and decreased expression of epithelial cadherin in human papillomavirus-positive tonsillar cancer: an early event in human papillomavirus-related tumour progression?
Histopathology 2011;58(7):1117-26.
2010: Boris Klingenberg; Harriët C Hafkamp; Annick Haesevoets; Johannes J Manni; Pieter J Slootweg; Soenke J Weissenborn; Jens P Klussmann; Ernst J M Speel
p16 INK4A overexpression is frequently detected in tumour-free tonsil tissue without association with HPV.
Histopathology 2010;56(7):957-67.
2010: Wendy Theelen; Martin Reijans; Guus Simons; Frans C S Ramaekers; Ernst J M Speel; Anton H N Hopman
A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV-related cancers.
International journal of cancer. Journal international du cancer 2010;126(4):959-75.
2009: Jos M J A A Straetmans; Nadine Olthof; Jeroen J Mooren; Jos de Jong; Ernst J M Speel; Bernd Kremer
Human papillomavirus reduces the prognostic value of nodal involvement in tonsillar squamous cell carcinomas.
The Laryngoscope 2009;119(10):1951-7.
2009: Harriët C Hafkamp; Jeroen J Mooren; Sandra M H Claessen; Boris Klingenberg; Adri C Voogd; Fredrik J Bot; Jens Peter Klussmann; Anton H N Hopman; Johannes J Manni; Bernd Kremer; Frans C S Ramaekers; Ernst J M Speel
P21 Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009;22(5):686-98.
2009: Jens Peter Klussmann; Jeroen J Mooren; Martin Lehnen; Sandra M H Claessen; Markus Stenner; Christian U Huebbers; Soenke Weissenborn; Inga Wedemeyer; Simon Florian Preuss; Jos M J A A Straetmans; Johannes J Manni; Anton H N Hopman; Ernst J M Speel
Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(5):1779-86.
2009: Jens Peter Klussmann; Simon Florian Preuss; Ernst J M Speel
[Human papillomavirus and cancer of the oropharynx. Molecular interaction and clinical implications].
HNO 2009;57(2):113-22.
2008: Ernst J M Speel; Agnes J van de Wouw; S M H Claessen; Annick Haesevoets; Anton H N Hopman; Anneke A M van der Wurff; Rainhardt Osieka; Reinhard Buettner; H F P Hillen; Frans C S Ramaekers
Molecular evidence for a clonal relationship between multiple lesions in patients with unknown primary adenocarcinoma.
International journal of cancer. Journal international du cancer 2008;123(6):1292-300.
2008: V E Bergshoeff; A H N Hopman; I R Zwijnenberg; F C S Ramaekers; F J Bot; B Kremer; J J Manni; Ernst J M Speel
Chromosome instability in resection margins predicts recurrence of oral squamous cell carcinoma.
The Journal of pathology 2008;215(3):347-8.
2008: Harriët C Hafkamp; Johannes J Manni; Annick Haesevoets; A C Voogd; M Schepers; Fredrik J Bot; Anton H N Hopman; F C S Ramaekers; Ernst J M Speel
Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas.
International journal of cancer. Journal international du cancer 2008;122(12):2656-64.
2008: Bart-Jeroen Petri; Ernst J M Speel; Esther Korpershoek; S M H Claessen; Francien H van Nederveen; Vivian Giesen; Hilde Dannenberg; Erwin van der Harst; Winand N M Dinjens; Ronald R de Krijger
Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008;21(4):407-13.
2007: Serge J Smeets; Albertus T Hesselink; Ernst J M Speel; Annick Haesevoets; Peter J F Snijders; Michael Pawlita; Chris J L M Meijer; Boudewijn J M Braakhuis; René Leemans; Ruud H Brakenhoff
A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen.
International journal of cancer. Journal international du cancer 2007;121(11):2465-72.
2007: Ronald R de Krijger; S M H Claessen; Frieda van der Ham; Ad J M van Unnik; Christina A Hulsbergen-van de Kaa; Leen van Leuven; Max M van Noesel; Ernst J M Speel
Gain of chromosome 8q is a frequent finding in pleuropulmonary blastoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007;20(11):1191-9.
2007: Y M H Jonkers; S M H Claessen; Aurel Perren; Anja M Schmitt; Leo Hofland; W de Herder; Ronald R de Krijger; Albert A J Verhofstad; A R Hermus; J A Kummer; B Skogseid; M Volante; A C Voogd; Frans C S Ramaekers; Ernst J M Speel
DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients.
Endocrine-related cancer 2007;14(3):769-79.
2007: Giovanni Vitale; C H J van Eijck; Peter M van Koetsveld Ing; Joris I Erdmann; Ernst J M Speel; Katy van der Wansem Ing; Diana M Mooij; Annamaria Colao; Gaetano Lombardi; Ed Croze; Steven W J Lamberts; Leo J Hofland
Type I interferons in the treatment of pancreatic cancer: mechanisms of action and role of related receptors.
Annals of surgery 2007;246(2):259-68.
2007: Y M H Jonkers; Frans C S Ramaekers; Ernst J M Speel
Molecular alterations during insulinoma tumorigenesis.
Biochimica et biophysica acta 2007;1775(2):313-32.
2007: Niklas Reimers; Hans-Udo Kasper; Soenke Weissenborn; Hartmut Stützer; Simon Florian Preuss; Thomas K Hoffmann; Ernst J M Speel; Hans P Dienes; Herbert Pfister; Orlando Guntinas-Lichius; Jens Peter Klussmann
Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer.
International journal of cancer. Journal international du cancer 2007;120(8):1731-8.
2007: Georges P H Lucker; Ernst J M Speel; David H K Creytens; Adrienne J van Geest; Jolanda H M Peeters; S M H Claessen; Anton H M Vermeulen; Patrick Pauwels; Els V Meulemans
Differences in imiquimod treatment outcome in two patients with bowenoid papulosis containing either episomal or integrated human papillomavirus 16.
The Journal of investigative dermatology 2007;127(3):727-9.
2006: Y M H Jonkers; S M H Claessen; Ton Feuth; Ad Geurts van Kessel; Frans C S Ramaekers; Joris Veltman; Ernst J M Speel
Novel candidate tumour suppressor gene loci on chromosomes 11q23-24 and 22q13 involved in human insulinoma tumourigenesis.
The Journal of pathology 2006;210(4):450-8.
2006: Anton H N Hopman; W Theelen; P P H Hommelberg; Miriam A F Kamps; C S Herrington; L E Morrison; Ernst J M Speel; Frank Smedts; Frans C S Ramaekers
Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer.
The Journal of pathology 2006;210(4):412-9.
2006: Peter M Van Koetsveld; Giovanni Vitale; Wouter W de Herder; Richard A Feelders; Katy van der Wansem; Marlijn Waaijers; C H J van Eijck; Ernst J M Speel; Ed Croze; Aart Jan Van der Lely; Steven W J Lamberts; Leo J Hofland
Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth.
The Journal of clinical endocrinology and metabolism 2006;91(11):4537-43.
2006: Y M H Jonkers; S M H Claessen; Joris Veltman; Ad Geurts van Kessel; Winand N M Dinjens; B Skogseid; Frans C S Ramaekers; Ernst J M Speel
Molecular parameters associated with insulinoma progression: chromosomal instability versus p53 and CK19 status.
Cytogenetic and genome research 2006;115(3-4):289-97.
2006: Ernst J M Speel; Anton H N Hopman; Paul Komminoth
Tyramide signal amplification for DNA and mRNA in situ hybridization.
Methods in molecular biology (Clifton, N.J.) 2006;326():33-60.
2006: Marieke Aarts; Hilde Dannenberg; Ronald deLeeuw; Francien H van Nederveen; Albert A J Verhofstad; Jacques W M Lenders; Winand N M Dinjens; Ernst J M Speel; Wan L Lam; Ronald R de Krijger
Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p.
Genes, chromosomes & cancer 2006;45(1):83-93.
2005: Anton H N Hopman; Miriam A F Kamps; Frank Smedts; Ernst J M Speel; C Simon Herrington; Frans C S Ramaekers
HPV in situ hybridization: impact of different protocols on the detection of integrated HPV.
International journal of cancer. Journal international du cancer 2005;115(3):419-28.
2005: Y M H Jonkers; S M H Claessen; Aurel Perren; Sonja Schmid; Paul Komminoth; Albert A J Verhofstad; Leo Hofland; Ronald R de Krijger; P J Slootweg; Frans C S Ramaekers; Ernst J M Speel
Chromosomal instability predicts metastatic disease in patients with insulinomas.
Endocrine-related cancer 2005;12(2):435-47.
2004: Harriët C Hafkamp; Johannes J Manni; Ernst J M Speel
Role of human papillomavirus in the development of head and neck squamous cell carcinomas.
Acta oto-laryngologica 2004;124(4):520-6.
2004: Jens Peter Klussmann; S Dinh; Orlando Guntinas-Lichius; Claus Wittekindt; Soenke Weissenborn; Ulrike Wieland; Hans P Dienes; T Hoffmann; E Smith; Lubomir P Turek; Ernst J M Speel; Herbert Pfister
[HPV-associated tonsillar cancer. An update].
HNO 2004;52(3):208-18.
2004: Anton H N Hopman; Frank Smedts; Wendy Dignef; Monique Ummelen; Gabe Sonke; Marcel Mravunac; G Peter Vooijs; Ernst J M Speel; Frans C S Ramaekers
Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities.
The Journal of pathology 2004;202(1):23-33.
2004: Peter H Wessels; Albert Twijnstra; Bela Kubat; Monique Ummelen; S M H Claessen; Raf Sciot; Adrian Merlo; Frans C S Ramaekers; Ernst J M Speel; Anton H N Hopman
10q25.3 (DMBT1) copy number changes in astrocytoma grades II and IV.
Genes, chromosomes & cancer 2004;39(1):22-8.
2003: Harriët C Hafkamp; Ernst J M Speel; Annick Haesevoets; Fredrik J Bot; Winand N M Dinjens; Frans C S Ramaekers; Anton H N Hopman; Johannes J Manni
A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8.
International journal of cancer. Journal international du cancer 2003;107(3):394-400.
2003: Agnès J van de Wouw; R L H Jansen; Ernst J M Speel; H F P Hillen
The unknown biology of the unknown primary tumour: a literature review.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2003;14(2):191-6.
2003: Hilde Dannenberg; Paul Komminoth; Winand N M Dinjens; Ernst J M Speel; Ronald R de Krijger
Molecular genetic alterations in adrenal and extra-adrenal pheochromocytomas and paragangliomas.
Endocrine pathology 2003;14(4):329-50.
2003: Ernst J M Speel; Frans C S Ramaekers; Anton H N Hopman
Primed in situ nucleic Acid labeling combined with immunocytochemistry to simultaneously localize DNA and proteins in cells and chromosomes.
Methods in molecular biology (Clifton, N.J.) 2003;226():453-64.
2003: Ernst J M Speel; Frans C S Ramaekers; Anton H N Hopman
PCR-based detection of nucleic acids in chromosomes, cells, and tissues: technical considerations on PRINS and in situ PCR and comparison with in situ hybridization.
Methods in molecular biology (Clifton, N.J.) 2003;226():405-24.
2002: Anton H N Hopman; Miriam A F Kamps; Ernst J M Speel; Rene F M Schapers; Guido Sauter; Frans C S Ramaekers
Identification of chromosome 9 alterations and p53 accumulation in isolated carcinoma in situ of the urinary bladder versus carcinoma in situ associated with carcinoma.
The American journal of pathology 2002;161(4):1119-25.
2001: Jianming Zhao; Holger Moch; Alexander Scheidweiler; A Baer; A A Schäffer; Ernst J M Speel; Jürgen Roth; Philipp U Heitz; Paul Komminoth
Genomic imbalances in the progression of endocrine pancreatic tumors.
Genes, chromosomes & cancer 2001;32(4):364-72.
2001: Andre Barghorn; Paul Komminoth; D Bachmann; K Rütimann; Parvin Saremaslani; S Muletta-Feurer; Aurel Perren; Jürgen Roth; Philipp U Heitz; Ernst J M Speel
Deletion at 3p25.3-p23 is frequently encountered in endocrine pancreatic tumours and is associated with metastatic progression.
The Journal of pathology 2001;194(4):451-8.
2001: Ernst J M Speel; Alexander Scheidweiler; Jianming Zhao; Christian M Matter; Parvin Saremaslani; Jürgen Roth; Philipp U Heitz; Paul Komminoth
Genetic evidence for early divergence of small functioning and nonfunctioning endocrine pancreatic tumors: gain of 9Q34 is an early event in insulinomas.
Cancer research 2001;61(13):5186-92.
2001: Hilde Dannenberg; Ronald R de Krijger; J Zhao; Ernst J M Speel; Parvin Saremaslani; Winand N M Dinjens; Wolter J Mooi; Jürgen Roth; Philipp U Heitz; Paul Komminoth
Differential loss of chromosome 11q in familial and sporadic parasympathetic paragangliomas detected by comparative genomic hybridization.
The American journal of pathology 2001;158(6):1937-42.
2001: Andre Barghorn; Ernst J M Speel; B Farspour; Parvin Saremaslani; Sonja Schmid; Aurel Perren; Jürgen Roth; Philipp U Heitz; Paul Komminoth
Putative tumor suppressor loci at 6q22 and 6q23-q24 are involved in the malignant progression of sporadic endocrine pancreatic tumors.
The American journal of pathology 2001;158(6):1903-11.
2000: Jianming Zhao; Ronald R de Krijger; D Meier; Ernst J M Speel; Parvin Saremaslani; S Muletta-Feurer; Christian M Matter; Jürgen Roth; Philipp U Heitz; Paul Komminoth
Genomic alterations in well-differentiated gastrointestinal and bronchial neuroendocrine tumors (carcinoids): marked differences indicating diversity in molecular pathogenesis.
The American journal of pathology 2000;157(5):1431-8.
2000: Hilde Dannenberg; Ernst J M Speel; J Zhao; Parvin Saremaslani; Erwin van der Harst; Jürgen Roth; Philipp U Heitz; H Jaap Bonjer; Winand N M Dinjens; Wolter J Mooi; Paul Komminoth; Ronald R de Krijger
Losses of chromosomes 1p and 3q are early genetic events in the development of sporadic pheochromocytomas.
The American journal of pathology 2000;157(2):353-9.
2000: Ernst J M Speel; Anton H N Hopman; Paul Komminoth
Signal amplification for DNA and mRNA.
Methods in molecular biology (Clifton, N.J.) 2000;123():195-216.
1999: Ernst J M Speel; J Richter; Holger Moch; C Egenter; Parvin Saremaslani; K Rütimann; Jianming Zhao; Andre Barghorn; Jürgen Roth; Philipp U Heitz; Paul Komminoth
Genetic differences in endocrine pancreatic tumor subtypes detected by comparative genomic hybridization.
The American journal of pathology 1999;155(6):1787-94.
1999: Marco Volante; Mauro Papotti; J Roth; Parvin Saremaslani; Ernst J M Speel; Ricardo V Lloyd; J Aidan Carney; Philipp U Heitz; Gianni Bussolati; P Komminoth
Mixed medullary-follicular thyroid carcinoma. Molecular evidence for a dual origin of tumor components.
The American journal of pathology 1999;155(5):1499-509.
1999: Jianming Zhao; Ernst J M Speel; S Muletta-Feurer; K Rütimann; Parvin Saremaslani; Jürgen Roth; Philipp U Heitz; Paul Komminoth
Analysis of genomic alterations in sporadic adrenocortical lesions. Gain of chromosome 17 is an early event in adrenocortical tumorigenesis.
The American journal of pathology 1999;155(4):1039-45.
1999: Ernst J M Speel
Robert Feulgen Prize Lecture 1999. Detection and amplification systems for sensitive, multiple-target DNA and RNA in situ hybridization: looking inside cells with a spectrum of colors.
Histochemistry and cell biology 1999;112(2):89-113.
1999: Ernst J M Speel; Anton H N Hopman; Paul Komminoth
Amplification methods to increase the sensitivity of in situ hybridization: play card(s).
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999;47(3):281-8.
1999: B Görtz; Jürgen Roth; A Krähenmann; Ronald R de Krijger; S Muletta-Feurer; K Rütimann; Parvin Saremaslani; Ernst J M Speel; Philipp U Heitz; Paul Komminoth
Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms.
The American journal of pathology 1999;154(2):429-36.
1999: B Görtz; Jürgen Roth; Ernst J M Speel; A Krähenmann; Ronald R de Krijger; X Matias-Guiu; S Muletta-Feurer; K Rütmann; Parvin Saremaslani; Philipp U Heitz; Paul Komminoth
MEN1 gene mutation analysis of sporadic adrenocortical lesions.
International journal of cancer. Journal international du cancer 1999;80(3):373-9.
1999: Peter F.M. van der Ven; Ernst J M Speel; J C M Albrechts; Frans C S Ramaekers; Anton H N Hopman; Dieter O Fürst
Assignment of the human gene for endosarcomeric cytoskeletal M-protein (MYOM2) to 8p23.3.
Genomics 1999;55(2):253-5.
1998: Aurel Perren; Jürgen Roth; S Muletta-Feurer; Parvin Saremaslani; Ernst J M Speel; Philipp U Heitz; Paul Komminoth
Clonal analysis of sporadic pancreatic endocrine tumours.
The Journal of pathology 1998;186(4):363-71.
1998: Ernst J M Speel; Parvin Saremaslani; Jürgen Roth; Anton H N Hopman; Paul Komminoth
Improved mRNA in situ hybridization on formaldehyde-fixed and paraffin-embedded tissue using signal amplification with different haptenized tyramides.
Histochemistry and cell biology 1998;110(6):571-7.
1998: Ernst J M Speel; Peter F.M. van der Ven; J C M Albrechts; Frans C S Ramaekers; Dieter O Fürst; Anton H N Hopman
Assignment of the human gene for the sarcomeric M-band protein myomesin (MYOM1) to 18p11.31-p11.32.
Genomics 1998;54(1):184-6.
1998: Anton H N Hopman; Frans C S Ramaekers; Ernst J M Speel
Rapid synthesis of biotin-, digoxigenin-, trinitrophenyl-, and fluorochrome-labeled tyramides and their application for In situ hybridization using CARD amplification.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(6):771-7.
1997: Anton H N Hopman; S M H Claessen; Ernst J M Speel
Multi-colour brightfield in situ hybridisation on tissue sections.
Histochemistry and cell biology 1997;108(4-5):291-8.
1997: Ernst J M Speel; Frans C S Ramaekers; Anton H N Hopman
Sensitive multicolor fluorescence in situ hybridization using catalyzed reporter deposition (CARD) amplification.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1997;45(10):1439-46.
1997: Ernst J M Speel; D Lawson; Frans C S Ramaekers; JR Gosden; Anton H N Hopman
Combined immunocytochemistry and PRINS DNA synthesis for simultaneous detection of phenotypic and genomic parameters in cells.
Methods in molecular biology (Clifton, N.J.) 1997;71():53-9.
1997: Ernst J M Speel; D Lawson; Frans C S Ramaekers; JR Gosden; Anton H N Hopman
PRINS DNA synthesis on frozen tissue sections.
Methods in molecular biology (Clifton, N.J.) 1997;71():31-7.
1997: Ernst J M Speel; D Lawson; Frans C S Ramaekers; JR Gosden; Anton H N Hopman
Bright-field microscopic detection of oligonucleotide PRINS-labeled DNA in chromosome preparations.
Methods in molecular biology (Clifton, N.J.) 1997;71():13-22.
1996: Ernst J M Speel; D Lawson; Frans C S Ramaekers; JR Gosden; Anton H N Hopman
Rapid bright-field detection of oligonucleotide primed in situ (PRINS)-labeled DNA in chromosome preparations and frozen tissue sections.
BioTechniques 1996;20(2):226-34.
1996: J Herbergs; Ernst J M Speel; Frans C S Ramaekers; Adriaan P de Bruïne; Jan-Willem Arends; Anton H N Hopman
Combination of lamin immunocytochemistry and in situ hybridization for the analysis of chromosome copy numbers in tumor cell areas with high nuclear density.
Cytometry 1996;23(1):1-7.
1995: Ernst J M Speel; Frans C S Ramaekers; Anton H N Hopman
Cytochemical detection systems for in situ hybridization, and the combination with immunocytochemistry, 'who is still afraid of red, green and blue?'.
The Histochemical journal 1995;27(11):833-58.
1995: E Martini; Ernst J M Speel; Joep P M Geraedts; Frans C S Ramaekers; Anton H N Hopman
Application of different in-situ hybridization detection methods for human sperm analysis.
Human reproduction (Oxford, England) 1995;10(4):855-61.
1995: Ernst J M Speel; D Lawson; Anton H N Hopman; JR Gosden
Multi-PRINS: multiple sequential oligonucleotide primed in situ DNA synthesis reactions label specific chromosomes and produce bands.
Human genetics 1995;95(1):29-33.
1994: Ernst J M Speel; maurice jansen; Frans C S Ramaekers; Anton H N Hopman
A novel triple-color detection procedure for brightfield microscopy, combining in situ hybridization with immunocytochemistry.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(10):1299-307.
1994: Ernst J M Speel; J Herbergs; Frans C S Ramaekers; Anton H N Hopman
Combined immunocytochemistry and fluorescence in situ hybridization for simultaneous tricolor detection of cell cycle, genomic, and phenotypic parameters of tumor cells.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(7):961-6.
1993: Ernst J M Speel; M Kamps; J Bonnet; Frans C S Ramaekers; Anton H N Hopman
Multicolour preparations for in situ hybridization using precipitating enzyme cytochemistry in combination with reflection contrast microscopy.
Histochemistry 1993;100(5):357-66.
1992: Ernst J M Speel; Bert Schutte; J Wiegant; Frans C S Ramaekers; Anton H N Hopman
A novel fluorescence detection method for in situ hybridization, based on the alkaline phosphatase-fast red reaction.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(9):1299-308.
1992: Ernst J M Speel; Bert Schutte; Frans C S Ramaekers; Anton H N Hopman
The effect of avidin-biotin interactions in detection systems for in situ hybridization.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(1):135-41.