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Frank Speleman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Nucleic Acid Hybridization

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Van Vlierberghe Pieter; De Weer An; Mestdagh Pieter; Feys Tom; De Preter Katleen; De Paepe Pascale; Lambein Kathleen; Vandesompele Jo; Van Roy Nadine; Verhasselt Bruno; Poppe Bruce; Speleman Frank
Comparison of miRNA profiles of microdissected Hodgkin/Reed-Sternberg cells and Hodgkin cell lines versus CD77+ B-cells reveals a distinct subset of differentially expressed miRNAs.
Vermeulen Joëlle; De Preter Katleen; Laureys Geneviève; Speleman Frank; Vandesompele Jo
59-gene prognostic signature sub-stratifies high-risk neuroblastoma patients.
Buysse Karen; Delle Chiaie Barbara; Van Coster Rudy; Loeys Bart; De Paepe Anne; Mortier Geert; Speleman Frank; Menten Björn
Challenges for CNV interpretation in clinical molecular karyotyping: Lessons learned from a 1001 sample experience.

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All Publications

2009: Van Vlierberghe Pieter; De Weer An; Mestdagh Pieter; Feys Tom; De Preter Katleen; De Paepe Pascale; Lambein Kathleen; Vandesompele Jo; Van Roy Nadine; Verhasselt Bruno; Poppe Bruce; Speleman Frank
Comparison of miRNA profiles of microdissected Hodgkin/Reed-Sternberg cells and Hodgkin cell lines versus CD77+ B-cells reveals a distinct subset of differentially expressed miRNAs.
British journal of haematology 2009;147(5):686-90.
2009: Vermeulen Joëlle; De Preter Katleen; Laureys Geneviève; Speleman Frank; Vandesompele Jo
59-gene prognostic signature sub-stratifies high-risk neuroblastoma patients.
The lancet oncology 2009;10(11):1030.
2009: Buysse Karen; Delle Chiaie Barbara; Van Coster Rudy; Loeys Bart; De Paepe Anne; Mortier Geert; Speleman Frank; Menten Björn
Challenges for CNV interpretation in clinical molecular karyotyping: Lessons learned from a 1001 sample experience.
European journal of medical genetics 2009;52(6):398-403.
2009: Put Natalie; Konings Peter; Rack Katrina; Jamar Mauricette; Van Roy Nadine; Libouton Jeanne-Marie; Vannuffel Pascal; Sartenaer Daniel; Ameye Geneviève; Speleman Frank; Herens Christian; Poirel Hélène A; Moreau Yves; Hagemeijer Anne; Vandenberghe Peter; Michaux Lucienne;
Improved detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide and interleukin-2 stimulation: A Belgian multicentric study.
Genes, chromosomes & cancer 2009;48(10):843-53.
2009: Hoebeeck Jasmien; De Wilde Bram; Michels Evi; Combaret Valérie; Yigit Nurten; De Smet Els; Van Roy Nadine; Stanbridge Eric; Ru Ning; Laureys Geneviève; De Paepe Anne; Speleman Frank; Vandesompele Jo
Chromosome 3p microsatellite allelotyping in neuroblastoma: a report on the technical hurdles.
Cancer investigation 2009;27(8):857-68.
2009: D'haene Barbara; Attanasio Catia; Beysen Diane; Dostie Josée; Lemire Edmond; Bouchard Philippe; Field Michael; Jones Kristie; Lorenz Birgit; Menten Björn; Buysse Karen; Pattyn Filip; Friedli Marc; Ucla Catherine; Rossier Colette; Wyss Carine; Speleman Frank; De Paepe Anne; Dekker Job; Antonarakis Stylianos E; De Baere Elfride
Disease-causing 7.4 kb cis-regulatory deletion disrupting conserved non-coding sequences and their interaction with the FOXL2 promotor: implications for mutation screening.
PLoS genetics 2009;5(6):e1000522.
2009: De Preter Katleen; De Brouwer Sara; Van Maerken Tom; Pattyn Filip; Schramm Alexander; Eggert Angelika; Vandesompele Jo; Speleman Frank
Meta-mining of neuroblastoma and neuroblast gene expression profiles reveals candidate therapeutic compounds.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(11):3690-6.
2009: Van Maerken Tom; Sarkar Devanand; Speleman Frank; Dent Paul; Weiss William A; Fisher Paul B
Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma.
Journal of cellular physiology 2009;219(3):707-15.
2009: van de Wiel Mark A; Brosens Rebecca; Eilers Paul H C; Kumps Candy; Meijer Gerrit A; Menten Björn; Sistermans Erik; Speleman Frank; Timmerman Marieke E; Ylstra Bauke
Smoothing waves in array CGH tumor profiles.
Bioinformatics (Oxford, England) 2009;25(9):1099-104.
2009: Buysse Karen; Reardon William; Mehta Lakshmi; Costa Teresa; Fagerstrom Carrie; Kingsbury Daniel J; Anadiotis George; McGillivray Barbara C; Hellemans Jan; de Leeuw Nicole; de Vries Bert B A; Speleman Frank; Menten Björn; Mortier Geert
The 12q14 microdeletion syndrome: additional patients and further evidence that HMGA2 is an important genetic determinant for human height.
European journal of medical genetics 2009;52(2-3):101-7.
2009: Janoueix-Lerosey Isabelle; Schleiermacher Gudrun; Michels Evi; Mosseri Véronique; Ribeiro Agnès; Lequin Delphine; Vermeulen Joëlle; Couturier Jérôme; Peuchmaur Michel; Valent Alexander; Plantaz Dominique; Rubie Hervé; Valteau-Couanet Dominique; Thomas Caroline; Combaret Valérie; Rousseau Raphaël; Eggert Angelika; Michon Jean; Speleman Frank; Delattre Olivier
Overall genomic pattern is a predictor of outcome in neuroblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(7):1026-33.
2009: Buysse Karen; Antonacci Francesca; Callewaert Bert; Loeys Bart; Fränkel Ulrike; Siu Victoria; Mortier Geert; Speleman Frank; Menten Björn
Unusual 8p inverted duplication deletion with telomere capture from 8q.
European journal of medical genetics 2009;52(1):31-6.
2009: Menten Björn; Swerts Katrien; Delle Chiaie Barbara; Janssens Sandra; Buysse Karen; Philippé Jan; Speleman Frank
Array comparative genomic hybridization and flow cytometry analysis of spontaneous abortions and mors in utero samples.
BMC medical genetics 2009;10():89.
2009: Van Roy Nadine; De Preter Katleen; Hoebeeck Jasmien; Van Maerken Tom; Pattyn Filip; Mestdagh Pieter; Vermeulen Joëlle; Vandesompele Jo; Speleman Frank
The emerging molecular pathogenesis of neuroblastoma: implications for improved risk assessment and targeted therapy.
Genome medicine 2009;1(7):74.
2009: Mestdagh Pieter; Van Vlierberghe Pieter; De Weer An; Muth Daniel; Westermann Frank; Speleman Frank; Vandesompele Jo
A novel and universal method for microRNA RT-qPCR data normalization.
Genome biology 2009;10(6):R64.
2008: Mestdagh Pieter; Feys Tom; Bernard Nathalie; Guenther Simone; Chen Caifu; Speleman Frank; Vandesompele Jo
High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA.
Nucleic acids research 2008;36(21):e143.
2008: De Weer An; Speleman Frank; Cauwelier Barbara; Van Roy Nadine; Yigit Nurten; Verhasselt Bruno; De Moerloose Barbara; Benoit Yves; Noens Lucien; Selleslag Dominik; Lippert Eric; Struski Stephanie; Bastard Christian; De Paepe Anne; Vandenberghe Peter; Hagemeijer Anne; Dastugue Nicole; Poppe Bruce;
EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22.
Haematologica 2008;93(12):1903-7.
2008: Mossé Yaël P; Laudenslager Marci; Longo Luca; Cole Kristina A; Wood Andrew; Attiyeh Edward F; Laquaglia Michael J; Sennett Rachel; Lynch Jill E; Perri Patrizia; Laureys Geneviève; Speleman Frank; Kim Cecilia; Hou Cuiping; Hakonarson Hakon; Torkamani Ali; Schork Nicholas J; Brodeur Garrett M; Tonini Gian P; Rappaport Eric; Devoto Marcella; Maris John M
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 2008;455(7215):930-5.
2008: De Preter Katleen; Menten Björn; De Brouwer Sara; Kumps Candy; Michels Evi; Van Roy Nadine; Vandesompele Jo; Speleman Frank
Low-cost dedicated mini-arrays for high-throughput analysis of DNA copy-number alterations in neuroblastoma.
Cancer letters 2008;269(1):111-6.
2008: Buysse Karen; Menten Björn; Oostra Ann; Tavernier Sylvie; Mortier Geert R; Speleman Frank
Delineation of a critical region on chromosome 18 for the del(18)(q12.2q21.1) syndrome.
American journal of medical genetics. Part A 2008;146A(10):1330-4.
2008: De Preter Katleen; Barriot Roland; Speleman Frank; Vandesompele Jo; Moreau Yves
Positional gene enrichment analysis of gene sets for high-resolution identification of overrepresented chromosomal regions.
Nucleic acids research 2008;36(7):e43.
2008: Nair Prakash; De Preter Katleen; Vandesompele Jo; Speleman Frank; Stallings Raymond L
Aberrant splicing of the PTPRD gene mimics microdeletions identified at this locus in neuroblastomas.
Genes, chromosomes & cancer 2008;47(3):197-202.
2008: Vandesompele Jo; Michels Evi; De Preter Katleen; Menten Björn; Schramm Alexander; Eggert Angelika; Ambros Peter F; Combaret Valerie; Francotte Nadine; Antonacci Francesca; De Paepe Anne; Laureys Geneviève; Speleman Frank; Van Roy Nadine
Identification of 2 putative critical segments of 17q gain in neuroblastoma through integrative genomics.
International journal of cancer. Journal international du cancer 2008;122(5):1177-82.
2008: Speleman F; Kumps C; Buysse K; Poppe B; Menten B; De Preter K
Copy number alterations and copy number variation in cancer: close encounters of the bad kind.
Cytogenetic and genome research 2008;123(1-4):176-82.
2008: De Weer An; Poppe Bruce; Cauwelier Barbara; Carlier Andre; Dierick Jan; Verhasselt Bruno; Philippé Jan; Van Roy Nadine; Speleman Frank
EVI1 activation in blast crisis CML due to juxtaposition to the rare 17q22 partner region as part of a 4-way variant translocation t(9;22).
BMC cancer 2008;8():193.
2008: Michels Evi; Hoebeeck Jasmien; De Preter Katleen; Schramm Alexander; Brichard Bénédicte; De Paepe Anne; Eggert Angelika; Laureys Geneviève; Vandesompele Jo; Speleman Frank
CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23.
BMC cancer 2008;8():173.
2008: Vandepoele Karl; Andries Vanessa; Van Roy Nadine; Staes Katrien; Vandesompele Jo; Laureys Geneviève; De Smet Els; Berx Geert; Speleman Frank; van Roy Frans
A constitutional translocation t(1;17)(p36.2;q11.2) in a neuroblastoma patient disrupts the human NBPF1 and ACCN1 genes.
PloS one 2008;3(5):e2207.
2007: Michels Evi; Vandesompele Jo; De Preter Katleen; Hoebeeck Jasmien; Vermeulen Joëlle; Schramm Alexander; Molenaar Jan J; Menten Björn; Marques Barbara; Stallings Raymond L; Combaret Valérie; Devalck Christine; De Paepe Anne; Versteeg Rogier; Eggert Angelika; Laureys Geneviève; Van Roy Nadine; Speleman Frank
ArrayCGH-based classification of neuroblastoma into genomic subgroups.
Genes, chromosomes & cancer 2007;46(12):1098-108.
2007: Menten Björn; Buysse Karen; Vermeulen Stefan; Meersschaut Valerie; Vandesompele Jo; Ng Bee L; Carter Nigel P; Mortier Geert R; Speleman Frank
Report of a female patient with mental retardation and tall stature due to a chromosomal rearrangement disrupting the OPHN1 gene on Xq12.
European journal of medical genetics 2007;50(6):446-54.
2007: Vermeesch Joris Robert; Fiegler Heike; de Leeuw Nicole; Szuhai Karoly; Schoumans Jacqueline; Ciccone Roberto; Speleman Frank; Rauch Anita; Clayton-Smith Jill; Van Ravenswaaij Conny; Sanlaville Damien; Patsalis Philippos C; Firth Helen; Devriendt Koen; Zuffardi Orsetta
Guidelines for molecular karyotyping in constitutional genetic diagnosis.
European journal of human genetics : EJHG 2007;15(11):1105-14.
2007: Balikova Irina; Menten Björn; de Ravel Thomy; Le Caignec Cédric; Thienpont Bernard; Urbina Montse; Doco-Fenzy Martine; de Rademaeker Marjan; Mortier Geert; Kooy Frank; van den Ende Janneke; Devriendt Koen; Fryns Jean-Pierre; Speleman Frank; Vermeesch Joris Robert
Subtelomeric imbalances in phenotypically normal individuals.
Human mutation 2007;28(10):958-67.
2007: Michels Evi; De Preter Katleen; Van Roy Nadine; Speleman Frank
Detection of DNA copy number alterations in cancer by array comparative genomic hybridization.
Genetics in medicine : official journal of the American College of Medical Genetics 2007;9(9):574-84.
2007: Maertens Ophélia; De Schepper Sofie; Vandesompele Jo; Brems Hilde; Heyns Ine; Janssens Sandra; Speleman Frank; Legius Eric; Messiaen Ludwine
Molecular dissection of isolated disease features in mosaic neurofibromatosis type 1.
American journal of human genetics 2007;81(2):243-51.
2007: Feys Tom; Poppe Bruce; De Preter Katleen; Van Roy Nadine; Verhasselt Bruno; De Paepe Pascale; De Paepe Anne; Speleman Frank
A detailed inventory of DNA copy number alterations in four commonly used Hodgkin's lymphoma cell lines.
Haematologica 2007;92(7):913-20.
2007: Lahortiga Idoya; De Keersmaecker Kim; Van Vlierberghe Pieter; Graux Carlos; Cauwelier Barbara; Lambert Frederic; Mentens Nicole; Beverloo H Berna; Pieters Rob; Speleman Frank; Odero Maria D; Bauters Marijke; Froyen Guy; Marynen Peter; Vandenberghe Peter; Wlodarska Iwona; Meijerink Jules P P; Cools Jan
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.
Nature genetics 2007;39(5):593-5.
2007: Menten Björn; Buysse Karen; Zahir Farah; Hellemans Jan; Hamilton Sara J; Costa Teresa; Fagerstrom Carrie; Anadiotis George; Kingsbury Daniel; McGillivray Barbara C; Marra Marco A; Friedman Jan M; Speleman Frank; Mortier Geert
Osteopoikilosis, short stature and mental retardation as key features of a new microdeletion syndrome on 12q14.
Journal of medical genetics 2007;44(4):264-8.
2007: Schramm Alexander; Vandesompele Jo; Schulte Johannes H; Dreesmann Sabine; Kaderali Lars; Brors Benedikt; Eils Roland; Speleman Frank; Eggert Angelika
Translating expression profiling into a clinically feasible test to predict neuroblastoma outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(5):1459-65.
2007: Hoebeeck Jasmien; Michels Evi; Menten Björn; Van Roy Nadine; Eggert Angelika; Schramm Alexander; De Preter Katleen; Yigit Nurten; De Smet Els; De Paepe Anne; Laureys Geneviève; Vandesompele Jo; Speleman Frank
High resolution tiling-path BAC array deletion mapping suggests commonly involved 3p21-p22 tumor suppressor genes in neuroblastoma and more frequent tumors.
International journal of cancer. Journal international du cancer 2007;120(3):533-8.
2007: Speleman F; De Preter K; Hoebeeck J; Van Roy N; Vandesompele J
[New insights into the genetic basis of neuroblastoma]
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2007;69(4):167-96.
2007: Van Vooren Steven; Thienpont Bernard; Menten Björn; Speleman Frank; De Moor Bart; Vermeesch Joris; Moreau Yves
Mapping biomedical concepts onto the human genome by mining literature on chromosomal aberrations.
Nucleic acids research 2007;35(8):2533-43.
2007: Hoebeeck Jasmien; Speleman Frank; Vandesompele Jo
Real-time quantitative PCR as an alternative to Southern blot or fluorescence in situ hybridization for detection of gene copy number changes.
Methods in molecular biology (Clifton, N.J.) 2007;353():205-26.
2007: Hellemans Jan; Mortier Geert; De Paepe Anne; Speleman Frank; Vandesompele Jo
qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data.
Genome biology 2007;8(2):R19.
2006: Maertens Ophélia; Legius Eric; Speleman Frank; Messiaen Ludwine; Vandesompele Jo
Real-time quantitative allele discrimination assay using 3' locked nucleic acid primers for detection of low-percentage mosaic mutations.
Analytical biochemistry 2006;359(1):144-6.
2006: De Weer A; Poppe B; Cauwelier B; Van Roy N; Dastugue N; Hagemeijer A; De Paepe A; Speleman F
Screening for EVI1: ectopic expression absent in T-cell acute lymphoblastic leukemia patients and cell lines.
Cancer genetics and cytogenetics 2006;171(1):79-80.
2006: Van Maerken Tom; Speleman Frank; Vermeulen Joëlle; Lambertz Irina; De Clercq Sarah; De Smet Els; Yigit Nurten; Coppens Vicky; Philippé Jan; De Paepe Anne; Marine Jean-Christophe; Vandesompele Jo
Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma.
Cancer research 2006;66(19):9646-55.
2006: Maertens Ophélia; Brems Hilde; Vandesompele Jo; De Raedt Thomas; Heyns Ine; Rosenbaum Thorsten; De Schepper Sofie; De Paepe Anne; Mortier Geert; Janssens Sandra; Speleman Frank; Legius Eric; Messiaen Ludwine
Comprehensive NF1 screening on cultured Schwann cells from neurofibromas.
Human mutation 2006;27(10):1030-40.
2006: De Raedt Thomas; Maertens Ophélia; Chmara Magdalena; Brems Hilde; Heyns Ine; Sciot Raf; Majounie Elisa; Upadhyaya Meena; De Schepper Sofie; Speleman Frank; Messiaen Ludwine; Vermeesch Joris Robert; Legius Eric
Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients.
Genes, chromosomes & cancer 2006;45(10):893-904.
2006: Zatkova Andrea; Schoch Claudia; Speleman Frank; Poppe Bruce; Mannhalter Christine; Fonatsch Christa; Wimmer Katharina
GAB2 is a novel target of 11q amplification in AML/MDS.
Genes, chromosomes & cancer 2006;45(9):798-807.
2006: Hoebeeck Jasmien; Vandesompele Jo; Nilsson Helén; De Preter Katleen; Van Roy Nadine; De Smet Els; Yigit Nurten; De Paepe Anne; Laureys Geneviève; Påhlman Sven; Speleman Frank
The von Hippel-Lindau tumor suppressor gene expression level has prognostic value in neuroblastoma.
International journal of cancer. Journal international du cancer 2006;119(3):624-9.
2006: Menten B; Maas N; Thienpont B; Buysse K; Vandesompele J; Melotte C; de Ravel T; Van Vooren S; Balikova I; Backx L; Janssens S; De Paepe A; De Moor B; Moreau Y; Marynen P; Fryns J-P; Mortier G; Devriendt K; Speleman F; Vermeesch J R
Emerging patterns of cryptic chromosomal imbalance in patients with idiopathic mental retardation and multiple congenital anomalies: a new series of 140 patients and review of published reports.
Journal of medical genetics 2006;43(8):625-33.
2006: Cauwelier B; Dastugue N; Cools J; Poppe B; Herens C; De Paepe A; Hagemeijer A; Speleman F
Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRbeta locus rearrangements and putative new T-cell oncogenes.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(7):1238-44.
2006: Bergeron J; Clappier E; Cauwelier B; Dastugue N; Millien C; Delabesse E; Beldjord K; Speleman F; Soulier J; Macintyre E; Asnafi V
HOXA cluster deregulation in T-ALL associated with both a TCRD-HOXA and a CALM-AF10 chromosomal translocation.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(6):1184-7.
2006: Poppe Bruce; Dastugue Nicole; Vandesompele Jo; Cauwelier Barbara; De Smet Betty; Yigit Nurten; De Paepe Anne; Cervera Jose; Recher Christian; De Mas Véronique; Hagemeijer Anne; Speleman Frank
EVI1 is consistently expressed as principal transcript in common and rare recurrent 3q26 rearrangements.
Genes, chromosomes & cancer 2006;45(4):349-56.
2006: Maertens Ophélia; Prenen Hans; Debiec-Rychter Maria; Wozniak Agnieszka; Sciot Raf; Pauwels Patrick; De Wever Ivo; Vermeesch Joris R; de Raedt Thomas; De Paepe Anne; Speleman Frank; van Oosterom Allan; Messiaen Ludwine; Legius Eric
Molecular pathogenesis of multiple gastrointestinal stromal tumors in NF1 patients.
Human molecular genetics 2006;15(6):1015-23.
2006: Van Roy Nadine; Vandesompele Jo; Menten Björn; Nilsson Helén; De Smet Els; Rocchi Mariano; De Paepe Anne; Påhlman Sven; Speleman Frank
Translocation-excision-deletion-amplification mechanism leading to nonsyntenic coamplification of MYC and ATBF1.
Genes, chromosomes & cancer 2006;45(2):107-17.
2006: Gantois Ilse; Vandesompele Jo; Speleman Frank; Reyniers Edwin; D'Hooge Rudi; Severijnen Lies-Anne; Willemsen Rob; Tassone Flora; Kooy R Frank
Expression profiling suggests underexpression of the GABA(A) receptor subunit delta in the fragile X knockout mouse model.
Neurobiology of disease 2006;21(2):346-57.
2006: Pattyn Filip; Robbrecht Piet; De Paepe Anne; Speleman Frank; Vandesompele Jo
RTPrimerDB: the real-time PCR primer and probe database, major update 2006.
Nucleic acids research 2006;34(Database issue):D684-8.
2006: Michels E; Vandesompele J; Hoebeeck J; Menten B; De Preter K; Laureys G; Van Roy N; Speleman F
Genome wide measurement of DNA copy number changes in neuroblastoma: dissecting amplicons and mapping losses, gains and breakpoints.
Cytogenetic and genome research 2006;115(3-4):273-82.
2006: Pattyn Filip; Hoebeeck Jasmien; Robbrecht Piet; Michels Evi; De Paepe Anne; Bottu Guy; Coornaert David; Herzog Robert; Speleman Frank; Vandesompele Jo
methBLAST and methPrimerDB: web-tools for PCR based methylation analysis.
BMC bioinformatics 2006;7():496.
2006: De Preter Katleen; Vandesompele Jo; Heimann Pierre; Yigit Nurten; Beckman Siv; Schramm Alexander; Eggert Angelika; Stallings Raymond L; Benoit Yves; Renard Marleen; De Paepe Anne; Laureys Geneviève; Påhlman Sven; Speleman Frank
Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes.
Genome biology 2006;7(9):R84.
2005: Vandepoele Karl; Van Roy Nadine; Staes Katrien; Speleman Frank; van Roy Frans
A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.
Molecular biology and evolution 2005;22(11):2265-74.
2005: Poppe Bruce; Yigit Nurten; De Moerloose Barbara; De Paepe Anne; Benoit Yves; Speleman Frank
HOXA gene cluster rearrangement in a t(7;9)(p15;q34) in a child with MDS.
Cancer genetics and cytogenetics 2005;162(1):82-4.
2005: Poppe Bruce; De Paepe Pascale; Michaux Lucienne; Dastugue Nicole; Bastard Christian; Herens Christian; Moreau Els; Cavazzini Francesco; Yigit Nurten; Van Limbergen Heidi; De Paepe Anne; Praet Marleen; De Wolf-Peeters Chris; Wlodarska Iwona; Speleman Frank
PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements.
Genes, chromosomes & cancer 2005;44(2):218-23.
2005: Poppe Bruce; Cauwelier Barbara; Van Limbergen Heidi; Yigit Nurten; Philippé Jan; Verhasselt Bruno; De Paepe Anne; Benoit Yves; Speleman Frank
Novel cryptic chromosomal rearrangements in childhood acute lymphoblastic leukemia detected by multiple color fluorescent in situ hybridization.
Haematologica 2005;90(9):1179-85.
2005: Menten Björn; Buysse Karen; Vandesompele Jo; De Smet Els; De Paepe Anne; Speleman Frank; Mortier Geert
Identification of an unbalanced X-autosome translocation by array CGH in a boy with a syndromic form of chondrodysplasia punctata brachytelephalangic type.
European journal of medical genetics 2005;48(3):301-9.
2005: Pérez-Novo Claudina Angela; Claeys Cindy; Speleman Frank; Van Cauwenberge Paul; Bachert Claus; Vandesompele Jo
Impact of RNA quality on reference gene expression stability.
BioTechniques 2005;39(1):52, 54, 56.
2005: De Preter Katleen; Speleman Frank; Combaret Valérie; Lunec John; Board Julian; Pearson Andy; De Paepe Anne; Van Roy Nadine; Laureys Geneviève; Vandesompele Jo
No evidence for correlation of DDX1 gene amplification with improved survival probability in patients with MYCN-amplified neuroblastomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(13):3167-8; author reply 3168-70.
2005: Vandesompele Jo; Baudis Michael; De Preter Katleen; Van Roy Nadine; Ambros Peter; Bown Nick; Brinkschmidt Christian; Christiansen Holger; Combaret Valérie; Lastowska Maria; Nicholson James; O'Meara Anne; Plantaz Dominique; Stallings Raymond; Brichard Bénédicte; Van den Broecke Caroline; De Bie Sylvia; De Paepe Anne; Laureys Geneviève; Speleman Frank
Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(10):2280-99.
2005: Courtens Winnie; Vermeulen Stefan; Wuyts Wim; Messiaen Ludwine; Wauters Jan; Nuytinck Lieve; Peeters Nils; Storm Katrien; Speleman Frank; Nöthen Markus M
An interstitial deletion of chromosome 7 at band q21: a case report and review.
American journal of medical genetics. Part A 2005;134A(1):12-23.
2005: Vermeesch Joris R; Melotte Cindy; Froyen Guy; Van Vooren Steven; Dutta Binita; Maas Nicole; Vermeulen Stefan; Menten Björn; Speleman Frank; De Moor Bart; Van Hummelen Paul; Marynen Peter; Fryns Jean-Pierre; Devriendt Koen
Molecular karyotyping: array CGH quality criteria for constitutional genetic diagnosis.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(3):413-22.
2005: Speleman F; Cauwelier B; Dastugue N; Cools J; Verhasselt B; Poppe B; Van Roy N; Vandesompele J; Graux C; Uyttebroeck A; Boogaerts M; De Moerloose B; Benoit Y; Selleslag D; Billiet J; Robert A; Huguet F; Vandenberghe P; De Paepe A; Marynen P; Hagemeijer A
A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(3):358-66.
2005: Hoebeeck Jasmien; van der Luijt Rob; Poppe Bruce; De Smet Els; Yigit Nurten; Claes Kathleen; Zewald Richard; de Jong Gert-Jan; De Paepe Anne; Speleman Frank; Vandesompele Jo
Rapid detection of VHL exon deletions using real-time quantitative PCR.
Laboratory investigation; a journal of technical methods and pathology 2005;85(1):24-33.
2005: Vermeulen Stefan J; Speleman Frank; Vanransbeeck Leen; Verspeet Jasmien; Menten Björn; Verschraegen-Spae Marie-Rose; Wilde Philippe De; Messiaen Ludwine; Michaelis Ron C; Leroy Jules G
Familial pericentric inversion of chromosome 18: behavioral abnormalities in patients heterozygous for either the dup(18p)/del(18q) or dup(18q)/del(18p) recombinant chromosome.
European journal of human genetics : EJHG 2005;13(1):52-8.
2005: De Preter Katleen; Vandesompele Jo; Menten Björn; Carr Philippa; Fiegler Heike; Edsjö Anders; Carter Nigel P; Yigit Nurten; Waelput Wim; Van Roy Nadine; Bader Scott; Påhlman Sven; Speleman Frank
Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11.
BMC genomics 2005;6():97.
2005: Menten Björn; Pattyn Filip; De Preter Katleen; Robbrecht Piet; Michels Evi; Buysse Karen; Mortier Geert; De Paepe Anne; van Vooren Steven; Vermeesch Joris; Moreau Yves; De Moor Bart; Vermeulen Stefan; Speleman Frank; Vandesompele Jo
arrayCGHbase: an analysis platform for comparative genomic hybridization microarrays.
BMC bioinformatics 2005;6():124.
2004: Vermeulen Stefan J; Menten Björn; De Bie Sylvia; Coucke Paul; Malfait Fransiska; De Backer Julie; Speleman Frank; De Paepe Anne; Loeys Bart
DUP25 remains unconfirmed.
American journal of medical genetics. Part A 2004;131(3):320-1.
2004: Hellemans Jan; Preobrazhenska Olena; Willaert Andy; Debeer Philippe; Verdonk Peter C M; Costa Teresa; Janssens Katrien; Menten Bjorn; Van Roy Nadine; Vermeulen Stefan J T; Savarirayan Ravi; Van Hul Wim; Vanhoenacker Filip; Huylebroeck Danny; De Paepe Anne; Naeyaert Jean-Marie; Vandesompele Jo; Speleman Frank; Verschueren Kristin; Coucke Paul J; Mortier Geert R
Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.
Nature genetics 2004;36(11):1213-8.
2004: De Preter Katleen; Vandesompele Jo; Hoebeeck Jasmien; Vandenbroecke Caroline; Smet Jöel; Nuyts Annick; Laureys Geneviève; Combaret Valérie; Van Roy Nadine; Roels Frank; Van Coster Rudy; Praet Marleen; De Paepe Anne; Speleman Frank
No evidence for involvement of SDHD in neuroblastoma pathogenesis.
BMC cancer 2004;4():55.
2004: Stevens-Kroef M; Poppe B; van Zelderen-Bhola S; van den Berg E; van der Blij-Philipsen M; Geurts van Kessel A; Slater R; Hamers G; Michaux L; Speleman F; Hagemeijer A
Translocation t(2;3)(p15-23;q26-27) in myeloid malignancies: report of 21 new cases, clinical, cytogenetic and molecular genetic features.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(6):1108-14.
2004: Mathysen D; Van Roy N; Van Hul W; Laureys G; Ambros P; Speleman F; Wuyts W
Molecular analysis of the putative tumour-suppressor gene EXTL1 in neuroblastoma patients and cell lines.
European journal of cancer (Oxford, England : 1990) 2004;40(8):1255-61.
2004: Edsjö Anders; Nilsson Helén; Vandesompele Jo; Karlsson Jenny; Pattyn Filip; Culp Lloyd A; Speleman Frank; Påhlman Sven
Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation.
Laboratory investigation; a journal of technical methods and pathology 2004;84(4):406-17.
2004: Van Gele Mireille; Boyle Glen M; Cook Anthony L; Vandesompele Jo; Boonefaes Tom; Rottiers Pieter; Van Roy Nadine; De Paepe Anne; Parsons Peter G; Leonard J Helen; Speleman Frank
Gene-expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small-cell lung carcinoma.
Oncogene 2004;23(15):2732-42.
2004: De Preter Katleen; Pattyn Filip; Berx Geert; Strumane Kristin; Menten Björn; Van Roy Frans; De Paepe Anne; Speleman Frank; Vandesompele Jo
Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons.
BMC genomics 2004;5(1):11.
2004: Vermeulen Stefan; Menten Björn; Van Roy Nadine; Van Limbergen Heidi; De Paepe Anne; Mortier Geert; Speleman Frank
Molecular cytogenetic analysis of complex chromosomal rearrangements in patients with mental retardation and congenital malformations: delineation of 7q21.11 breakpoints.
American journal of medical genetics. Part A 2004;124A(1):10-8.
2004: Cavé Hélène; Suciu Stefan; Preudhomme Claude; Poppe Bruce; Robert Alain; Uyttebroeck Anne; Malet Michèle; Boutard Patrick; Benoit Yves; Mauvieux Laurent; Lutz Patrick; Méchinaud Françoise; Grardel Nathalie; Mazingue Francoise; Dupont Madeleine; Margueritte Geneviève; Pages Marie-Pierre; Bertrand Yves; Plouvier Emmanuel; Brunie Ghislaine; Bastard Christian; Plantaz Dominique; Vande Velde Isabel; Hagemeijer Anne; Speleman Frank; Lessard Michel; Otten Jacques; Vilmer Etienne; Dastugue Nicole;
Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.
Blood 2004;103(2):442-50.
2004: Poppe Bruce; Vandesompele Jo; Schoch Claudia; Lindvall Charlotta; Mrozek Krzysztof; Bloomfield Clara D; Beverloo H Berna; Michaux Lucienne; Dastugue Nicole; Herens Christian; Yigit Nurten; De Paepe Anne; Hagemeijer Anne; Speleman Frank
Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies.
Blood 2004;103(1):229-35.
2003: De Paepe Pascale; Baens Mathijs; van Krieken Han; Verhasselt Bruno; Stul Michel; Simons Annet; Poppe Bruce; Laureys Geneviève; Brons Paul; Vandenberghe Peter; Speleman Frank; Praet Marleen; De Wolf-Peeters Chris; Marynen Peter; Wlodarska Iwona
ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma.
Blood 2003;102(7):2638-41.
2003: Pérez Claudina; Vandesompele Jo; Vandenbroucke Ina; Holtappels Gabriele; Speleman Frank; Gevaert Philippe; Van Cauwenberge Paul; Bachert Claus
Quantitative real time polymerase chain reaction for measurement of human interleukin-5 receptor alpha spliced isoforms mRNA.
BMC biotechnology 2003;3():17.
2003: De Preter Katleen; Vandesompele Jo; Heimann Pierre; Kockx Mark M; Van Gele Mireille; Hoebeeck Jasmien; De Smet Els; Demarche Martine; Laureys Geneviève; Van Roy Nadine; De Paepe Anne; Speleman Frank
Application of laser capture microdissection in genetic analysis of neuroblastoma and neuroblastoma precursor cells.
Cancer letters 2003;197(1-2):53-61.
2003: Van Roy Nadine; Van Gele Mireille; Vandesompele Jo; Messiaen Ludwine; Van Belle Simon; Sciot Raf; Mortéle Koen; Gyselinck Jan; Michiels Erna; Forsyth Ramses; Van Marck Erik; De Paepe Anne; Speleman Frank
Evidence for involvement of a tumor suppressor gene on 1p in malignant peripheral nerve sheath tumors.
Cancer genetics and cytogenetics 2003;143(2):120-4.
2003: Dodé Catherine; Levilliers Jacqueline; Dupont Jean-Michel; De Paepe Anne; Le Dû Nathalie; Soussi-Yanicostas Nadia; Coimbra Roney S; Delmaghani Sedigheh; Compain-Nouaille Sylvie; Baverel Françoise; Pêcheux Christophe; Le Tessier Dominique; Cruaud Corinne; Delpech Marc; Speleman Frank; Vermeulen Stefan; Amalfitano Andrea; Bachelot Yvan; Bouchard Philippe; Cabrol Sylvie; Carel Jean-Claude; Delemarre-van de Waal Henriette; Goulet-Salmon Barbara; Kottler Marie-Laure; Richard Odile; Sanchez-Franco Franco; Saura Robert; Young Jacques; Petit Christine; Hardelin Jean-Pierre
Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome.
Nature genetics 2003;33(4):463-5.
2003: Vandesompele Jo; Edsjö Anders; De Preter Katleen; Axelson Håkan; Speleman Frank; Påhlman Sven
ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value.
Oncogene 2003;22(3):456-60.
2003: Pattyn Filip; Speleman Frank; De Paepe Anne; Vandesompele Jo
RTPrimerDB: the real-time PCR primer and probe database.
Nucleic acids research 2003;31(1):122-3.
2003: Depreter Marianne; Vandesompele Jo; Ferdinandusse Sacha; Speleman Frank; Roels Frank
Regulation of peroxisomal genes by DHEA and vitamin D.
Advances in experimental medicine and biology 2003;544():237-42.
2002: Depreter M; Vandesompele J; Espeel M; Speleman F; Roels F
Modulation of the peroxisomal gene expression pattern by dehydroepiandrosterone and vitamin D: therapeutic implications.
The Journal of endocrinology 2002;175(3):779-92.
2002: Van Roy Nadine; Vandesompele Jo; Berx Geert; Staes Katrien; Van Gele Mireille; De Smet Els; De Paepe Anne; Laureys Geneviève; van der Drift Pauline; Versteeg Rogier; Van Roy Frans; Speleman Frank
Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients.
Genes, chromosomes & cancer 2002;35(2):113-20.
2002: Van Gele Mireille; Leonard J Helen; Van Roy Nadine; Van Limbergen Heidi; Van Belle Simon; Cocquyt Veronique; Salwen Helen; De Paepe Anne; Speleman Frank
Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.
International journal of cancer. Journal international du cancer 2002;101(2):137-45.
2002: Leonard J Helen; Cook Anthony L; Van Gele Mireille; Boyle Glen M; Inglis Kelly J; Speleman Frank; Sturm Richard A
Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.
International journal of cancer. Journal international du cancer 2002;101(2):103-10.
2002: Vandesompele Jo; De Preter Katleen; Pattyn Filip; Poppe Bruce; Van Roy Nadine; De Paepe Anne; Speleman Frank
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.
Genome biology 2002;3(7):RESEARCH0034.
2002: Vandesompele Jo; Speleman Frank
A brief commentary on "Chromosomal aberrations in neuroblastoma cell lines identified by cross species color banding and chromosome painting".
Cancer genetics and cytogenetics 2002;135(2):196.
2002: Vermeulen Stefan; Messiaen Ludwine; Scheir Petra; De Bie Sylvia; Speleman Frank; De Paepe Anne
Kallmann syndrome in a patient with congenital spherocytosis and an interstitial 8p11.2 deletion.
American journal of medical genetics 2002;108(4):315-8.
2002: Vandesompele Jo; De Paepe Anne; Speleman Frank
Elimination of primer-dimer artifacts and genomic coamplification using a two-step SYBR green I real-time RT-PCR.
Analytical biochemistry 2002;303(1):95-8.
2002: Van Limbergen H; Poppe B; Janssens A; De Bock R; De Paepe A; Noens L; Speleman F
Molecular cytogenetic analysis of 10;11 rearrangements in acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(3):344-51.
2002: De Preter Katleen; Speleman Frank; Combaret Valérie; Lunec John; Laureys Geneviève; Eussen Bert H J; Francotte Nadine; Board Julian; Pearson Andy D J; De Paepe Anne; Van Roy Nadine; Vandesompele Jo
Quantification of MYCN, DDX1, and NAG gene copy number in neuroblastoma using a real-time quantitative PCR assay.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2002;15(2):159-66.
2002: Van Limbergen Heidi; Poppe Bruce; Michaux Lucienne; Herens Christian; Brown Jill; Noens Luc; Berneman Zwi; De Bock Robrecht; De Paepe Anne; Speleman Frank
Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.
Genes, chromosomes & cancer 2002;33(1):60-72.
2001: Van Roy N; Van Limbergen H; Vandesompele J; Van Gele M; Poppe B; Salwen H; Laureys G; Manoel N; De Paepe A; Speleman F
Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.
Genes, chromosomes & cancer 2001;32(2):126-35.
2001: Poppe B; Van Limbergen H; Van Roy N; Vandecruys E; De Paepe A; Benoit Y; Speleman F
Chromosomal aberrations in Bloom syndrome patients with myeloid malignancies.
Cancer genetics and cytogenetics 2001;128(1):39-42.
2001: Van Gele M; Leonard J H; Van Roy N; Cook A L; De Paepe A; Speleman F
Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma.
International journal of cancer. Journal international du cancer 2001;92(3):409-13.
2001: Plantaz D; Vandesompele J; Van Roy N; Lastowska M; Bown N; Combaret V; Favrot M C; Delattre O; Michon J; Bénard J; Hartmann O; Nicholson J C; Ross F M; Brinkschmidt C; Laureys G; Caron H; Matthay K K; Feuerstein B G; Speleman F
Comparative genomic hybridization (CGH) analysis of stage 4 neuroblastoma reveals high frequency of 11q deletion in tumors lacking MYCN amplification.
International journal of cancer. Journal international du cancer 2001;91(5):680-6.
2001: Van Limbergen H; Beverloo H B; van Drunen E; Janssens A; Hählen K; Poppe B; Van Roy N; Marynen P; De Paepe A; Slater R; Speleman F
Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia.
Genes, chromosomes & cancer 2001;30(3):274-82.
2001: Vandesompele J; Speleman F; Van Roy N; Laureys G; Brinskchmidt C; Christiansen H; Lampert F; Lastowska M; Bown N; Pearson A; Nicholson J C; Ross F; Combaret V; Delattre O; Feuerstein B G; Plantaz D
Multicentre analysis of patterns of DNA gains and losses in 204 neuroblastoma tumors: how many genetic subgroups are there?
Medical and pediatric oncology 2001;36(1):5-10.
2001: Lastowska M; Van Roy N; Bown N; Speleman F; Roberts P; Lunec J; Strachan T; Pearson A D; Jackson M S
Molecular cytogenetic definition of 17q translocation breakpoints in neuroblastoma.
Medical and pediatric oncology 2001;36(1):20-3.
2000: Van Roy N; Van Limbergen H; Vandesompele J; Van Gele M; Poppe B; Laureys G; De Paepe A; Speleman F
Chromosome 2 short arm translocations revealed by M-FISH analysis of neuroblastoma cell lines.
Medical and pediatric oncology 2000;35(6):538-40.
2000: Speleman F; Callens B; Logghe K; Van Roy N; Horsley S W; Jauch A; Verschraegen-Spae M R; Leroy J G
Subtelomeric familial translocation t(2;7)(q37;q35) leading to partial trisomy 7q35-->qter: molecular cytogenetic analysis and clinical phenotype in two generations.
American journal of medical genetics 2000;93(5):349-54.
2000: Judson H; van Roy N; Strain L; Vandesompele J; Van Gele M; Speleman F; Bonthron D T
Structure and mutation analysis of the gene encoding DNA fragmentation factor 40 (caspase-activated nuclease), a candidate neuroblastoma tumour suppressor gene.
Human genetics 2000;106(4):406-13.
2000: Van Gele M; Kaghad M; Leonard J H; Van Roy N; Naeyaert J M; Geerts M L; Van Belle S; Cocquyt V; Bridge J; Sciot R; De Wolf-Peeters C; De Paepe A; Caput D; Speleman F
Mutation analysis of P73 and TP53 in Merkel cell carcinoma.
British journal of cancer 2000;82(4):823-6.
2000: Spieker N; Beitsma M; van Sluis P; Roobeek I; den Dunnen J T; Speleman F; Caron H; Versteeg R
An integrated 5-Mb physical, genetic, and radiation hybrid map of a 1p36.1 region implicated in neuroblastoma pathogenesis.
Genes, chromosomes & cancer 2000;27(2):143-52.
2000: Leonard J H; Cook A L; Nancarrow D; Hayward N; Van Gele M; Van Roy N; Speleman F
Deletion mapping on the short arm of chromosome 1 in Merkel cell carcinoma.
Cancer detection and prevention 2000;24(6):620-7.
2000: Messiaen L M; Callens T; Mortier G; Beysen D; Vandenbroucke I; Van Roy N; Speleman F; Paepe A D
Exhaustive mutation analysis of the NF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects.
Human mutation 2000;15(6):541-55.
1999: Bown N; Cotterill S; Lastowska M; O'Neill S; Pearson A D; Plantaz D; Meddeb M; Danglot G; Brinkschmidt C; Christiansen H; Laureys G; Speleman F; Nicholson J; Bernheim A; Betts D R; Vandesompele J; Van Roy N
Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma.
The New England journal of medicine 1999;340(25):1954-61.
1999: Du Plessis L; Dietzsch E; Van Gele M; Van Roy N; Van Helden P; Parker M I; Mugwanya D K; De Groot M; Marx M P; Kotze M J; Speleman F
Mapping of novel regions of DNA gain and loss by comparative genomic hybridization in esophageal carcinoma in the Black and Colored populations of South Africa.
Cancer research 1999;59(8):1877-83.
1999: De Moerloose B; Van de Wiele C; Dhooge C; Philippé J; Speleman F; Benoit Y; Laureys G; Dierckx R A
Technetium-99m sestamibi imaging in paediatric neuroblastoma and ganglioneuroma and its relation to P-glycoprotein.
European journal of nuclear medicine 1999;26(4):396-403.
1999: De Baere E; Van Roy N; Speleman F; Fukushima Y; De Paepe A; Messiaen L
Closing in on the BPES gene on 3q23: mapping of a de Novo reciprocal translocation t(3;4)(q23;p15.2) breakpoint within a 45-kb cosmid and mapping of three candidate genes, RBP1, RBP2, and beta'-COP, distal to the breakpoint.
Genomics 1999;57(1):70-8.
1999: Vermeulen S J; Nollet F; Teugels E; Vennekens K M; Malfait F; Philippé J; Speleman F; Bracke M E; van Roy F M; Mareel M M
The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells.
Oncogene 1999;18(4):905-15.
1999: Vermeulen S J; Debruyne P R; Marra G; Speleman F P; Boukamp P; Jiricny J; Cuthbert A P; Newbold R F; Nollet F H; van Roy F M; Mareel M M
hMSH6 deficiency and inactivation of the alphaE-catenin invasion-suppressor gene in HCT-8 colon cancer cells.
Clinical & experimental metastasis 1999;17(8):663-8.
1999: Wuyts W; Spieker N; Van Roy N; De Boulle K; De Paepe A; Willems P J; Van Hul W; Versteeg R; Speleman F
Refined physical mapping and genomic structure of the EXTL1 gene.
Cytogenetics and cell genetics 1999;86(3-4):267-70.
1998: Vermeulen S J; Chen T R; Speleman F; Nollet F; Van Roy F M; Mareel M M
Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?
Cancer genetics and cytogenetics 1998;107(1):76-9.
1998: Vandesompele J; Van Roy N; Van Gele M; Laureys G; Ambros P; Heimann P; Devalck C; Schuuring E; Brock P; Otten J; Gyselinck J; De Paepe A; Speleman F
Genetic heterogeneity of neuroblastoma studied by comparative genomic hybridization.
Genes, chromosomes & cancer 1998;23(2):141-52.
1998: Lastowska M; Van Roy N; Bown N; Speleman F; Lunec J; Strachan T; Pearson A D; Jackson M S
Molecular cytogenetic delineation of 17q translocation breakpoints in neuroblastoma cell lines.
Genes, chromosomes & cancer 1998;23(2):116-22.
1998: Van Gele M; Van Roy N; Ronan S G; Messiaen L; Vandesompele J; Geerts M L; Naeyaert J M; Blennow E; Bar-Am I; Das Gupta T K; van der Drift P; Versteeg R; Leonard J H; Speleman F
Molecular analysis of 1p36 breakpoints in two Merkel cell carcinomas.
Genes, chromosomes & cancer 1998;23(1):67-71.
1998: Dierlamm J; Stul M; Vranckx H; Michaux L; Weghuis D E; Speleman F; Selleslag D; Kramer M H; Noens L A; Cassiman J J; Van den Berghe H; Hagemeijer A
FISH identifies inv(16)(p13q22) masked by translocations in three cases of acute myeloid leukemia.
Genes, chromosomes & cancer 1998;22(2):87-94.
1998: Van Gele M; Speleman F; Vandesompele J; Van Roy N; Leonard J H
Characteristic pattern of chromosomal gains and losses in Merkel cell carcinoma detected by comparative genomic hybridization.
Cancer research 1998;58(7):1503-8.
1998: Speleman F; van den Berg E; Dhooge C; Oosterhuis W; Redeker B; De Potter C R; Tamminga R Y; Van Roy N; Mannens M
Cytogenetic and molecular analysis of cellular atypical mesoblastic nephroma.
Genes, chromosomes & cancer 1998;21(3):265-9.
1998: Mortelé K; Lemmerling M; Defreyne L; Speleman F; De Potter C; Van Belle S; Kunnen M
Ossified retroperitoneal malignant Schwannoma with spinal leptomeningeal metastases.
Neuroradiology 1998;40(1):48-50.
1998: Van Hul W; Wuyts W; Hendrickx J; Speleman F; Wauters J; De Boulle K; Van Roy N; Bossuyt P; Willems P J
Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family.
Genomics 1998;47(2):230-7.
1998: De Baere E; Speleman F; Van Roy N; Mortier K; De Paepe A; Messiaen L
Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization.
Cytogenetics and cell genetics 1998;83(3-4):240-1.
1998: De Baere E; Speleman F; Van Roy N; De Paepe A; Messiaen L
Assignment of SHOX2 (alias OG12X and SHOT) to human chromosome bands 3q25-->q26.1 by in situ hybridization.
Cytogenetics and cell genetics 1998;82(3-4):228-9.
1998: De Baere E; Speleman F; Van Roy N; De Paepe A; Messiaen L
Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization.
Cytogenetics and cell genetics 1998;82(3-4):226-7.
1997: Vermeulen S J; Nollet F; Teugels E; Philippe J; Speleman F; van Roy F M; Bracke M E; Mareel M M
Mutation of alpha-catenin results in invasiveness of human HCT-8 colon cancer cells.
Annals of the New York Academy of Sciences 1997;833():186-9.
1997: Wuyts W; Van Hul W; Hendrickx J; Speleman F; Wauters J; De Boulle K; Van Roy N; Van Agtmael T; Bossuyt P; Willems P J
Identification and characterization of a novel member of the EXT gene family, EXTL2.
European journal of human genetics : EJHG 1997;5(6):382-9.
1997: Van Gele M; Van Roy N; Jauch A; Laureys G; Benoit Y; Schelfhout V; De Potter C R; Brock P; Uyttebroeck A; Sciot R; Schuuring E; Versteeg R; Speleman F
Sensitive and reliable detection of genomic imbalances in human neuroblastomas using comparative genomic hybridisation analysis.
European journal of cancer (Oxford, England : 1990) 1997;33(12):1979-82.
1997: Van Roy N; Laureys G; Van Gele M; Opdenakker G; Miura R; van der Drift P; Chan A; Versteeg R; Speleman F
Analysis of 1;17 translocation breakpoints in neuroblastoma: implications for mapping of neuroblastoma genes.
European journal of cancer (Oxford, England : 1990) 1997;33(12):1974-8.
1997: Van Roy N; Jauch A; Van Gele M; Laureys G; Versteeg R; De Paepe A; Cremer T; Speleman F
Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.
Cancer genetics and cytogenetics 1997;97(2):135-42.
1997: Speleman F; Dermaut B; De Potter C R; Van Gele M; Van Roy N; De Paepe A; Laureys G
Monosomy 22 in a mixed germ cell-sex cord-stromal tumor of the ovary.
Genes, chromosomes & cancer 1997;19(3):192-4.
1997: Vermeesch J R; Petit P; Speleman F; Devriendt K; Fryns J P; Marynen P
Interstitial telomeric sequences at the junction site of a jumping translocation.
Human genetics 1997;99(6):735-7.
1997: Coene E D; Schelfhout V; Winkler R A; Schelfhout A M; Van Roy N; Grooteclaes M; Speleman F; De Potter C R
Amplification units and translocation at chromosome 17q and c-erbB-2 overexpression in the pathogenesis of breast cancer.
Virchows Archiv : an international journal of pathology 1997;430(5):365-72.
1997: Speleman F; Delattre O; Peter M; Hauben E; Van Roy N; Van Marck E
Malignant melanoma of the soft parts (clear-cell sarcoma): confirmation of EWS and ATF-1 gene fusion caused by a t(12;22) translocation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1997;10(5):496-9.
1996: Speleman F; De Potter C; Van Roy N; Laureys G
Multiple polysomies in nasal polyps in children.
Cancer genetics and cytogenetics 1996;90(1):86-7.
1996: Van den Enden A; Verschraegen-Spae M R; Van Roy N; Decaluwe W; De Praeter C; Speleman F
Mosaic tetrasomy 15q25-->qter in a newborn infant with multiple anomalies.
American journal of medical genetics 1996;63(3):482-5.
1996: Cheng N C; Chan A J; Beitsma M M; Speleman F; Westerveld A; Versteeg R
A human modifier of methylation for class I HLA genes (MEMO-1) maps to chromosomal bands 1p35-36.1.
Human molecular genetics 1996;5(3):309-17.
1996: Speleman F; Van Camp G; Van Roy N
Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization.
Cytogenetics and cell genetics 1996;72(2-3):189-90.
1996: Messiaen L; Leroy B P; De Bie S; De Pauw K; Van Roy N; Speleman F; Van Camp G; De Paepe A
Refined genetic and physical mapping of BPES type II.
European journal of human genetics : EJHG 1996;4(1):34-8.
1996: Speleman F; Vervoort R; van Roy N; Liebaers I; Sly W S; Lissens W
Localization by fluorescence in situ hybridization of the human functional beta-glucuronidase gene (GUSB) to 7q11.21 --> q11.22 and two pseudogenes to 5p13 and 5q13.
Cytogenetics and cell genetics 1996;72(1):53-5.
1995: Van Camp G; Coucke P; Speleman F; Van Roy N; Beyer E C; Oostra B A; Willems P J
The gene for human gap junction protein connexin37 (GJA4) maps to chromosome 1p35.1, in the vicinity of D1S195.
Genomics 1995;30(2):402-3.
1995: van der Drift P; Chan A; Laureys G; van Roy N; Sickmann G; den Dunnen J; Westerveld A; Speleman F; Versteeg R
Balanced translocation in a neuroblastoma patient disrupts a cluster of small nuclear RNA U1 and tRNA genes in chromosomal band 1p36.
Genes, chromosomes & cancer 1995;14(1):35-42.
1995: Van Roy N; Forus A; Myklebost O; Cheng N C; Versteeg R; Speleman F
Identification of two distinct chromosome 12-derived amplification units in neuroblastoma cell line NGP.
Cancer genetics and cytogenetics 1995;82(2):151-4.
1995: Caron H; Peter M; van Sluis P; Speleman F; de Kraker J; Laureys G; Michon J; Brugières L; Voûte P A; Westerveld A
Evidence for two tumour suppressor loci on chromosomal bands 1p35-36 involved in neuroblastoma: one probably imprinted, another associated with N-myc amplification.
Human molecular genetics 1995;4(4):535-9.
1995: Laureys G; Speleman F; Versteeg R; van der Drift P; Chan A; Leroy J; Francke U; Opdenakker G; Van Roy N
Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers.
Oncogene 1995;10(6):1087-93.
1995: Cheng N C; Van Roy N; Chan A; Beitsma M; Westerveld A; Speleman F; Versteeg R
Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.
Oncogene 1995;10(2):291-7.
1995: van Hengel J; Nollet F; Berx G; van Roy N; Speleman F; van Roy F
Assignment of the human beta-catenin gene (CTNNB1) to 3p22-->p21.3 by fluorescence in situ hybridization.
Cytogenetics and cell genetics 1995;70(1-2):68-70.
1995: Van Roy N; Cheng N C; Laureys G; Opdenakker G; Versteeg R; Speleman F
Molecular cytogenetic analysis of 1;17 translocations in neuroblastoma.
European journal of cancer (Oxford, England : 1990) 1995;31A(4):530-5.
1995: Laureys G; Versteeg R; Speleman F; van der Drift P; Francke U; Opdenakker G; Van Roy N
Characterisation of the chromosome breakpoints in a patient with a constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12) and neuroblastoma.
European journal of cancer (Oxford, England : 1990) 1995;31A(4):523-6.
1994: van der Drift P; Chan A; van Roy N; Laureys G; Westerveld A; Speleman F; Versteeg R
A multimegabase cluster of snRNA and tRNA genes on chromosome 1p36 harbours an adenovirus/SV40 hybrid virus integration site.
Human molecular genetics 1994;3(12):2131-6.
1994: Dal Cin P; Sciot R; Speleman F; Samson I; Laureys G; de Potter C; Meire F; van Damme B; van den Berghe H
Chromosome aberrations in fibrous dysplasia.
Cancer genetics and cytogenetics 1994;77(2):114-7.
1994: Caron H; van Sluis P; van Roy N; de Kraker J; Speleman F; Voûte P A; Westerveld A; Slater R; Versteeg R
Recurrent 1;17 translocations in human neuroblastoma reveal nonhomologous mitotic recombination during the S/G2 phase as a novel mechanism for loss of heterozygosity.
American journal of human genetics 1994;55(2):341-7.
1994: Duval E; van den Enden A; Vanhaesebrouck P; Speleman F
Jumping translocation in a newborn boy with dup(4q) and severe hydrops fetalis.
American journal of medical genetics 1994;52(2):214-7.
1994: Courtens W; Petersen M B; Noël J C; Flament-Durand J; Van Regemorter N; Delneste D; Cochaux P; Verschraegen-Spae M R; Van Roy N; Speleman F
Proximal deletion of chromosome 21 confirmed by in situ hybridization and molecular studies.
American journal of medical genetics 1994;51(3):260-5.
1994: Van Roy N; Laureys G; Cheng N C; Willem P; Opdenakker G; Versteeg R; Speleman F
1;17 translocations and other chromosome 17 rearrangements in human primary neuroblastoma tumors and cell lines.
Genes, chromosomes & cancer 1994;10(2):103-14.
1994: Opdenakker G; Fiten P; Nys G; Froyen G; Van Roy N; Speleman F; Laureys G; Van Damme J
The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.
Genomics 1994;21(2):403-8.
1994: Dhooge C; Van Roy N; Craen M; Speleman F
Direct transmission of a tandem duplication in the short arm of chromosome 8.
Clinical genetics 1994;45(1):36-9.
1994: Hilliker C; Delabie J; Speleman F; Bilbe G; Bruggen J; Van Leuven F; Van den Berghe H
Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus.
Cytogenetics and cell genetics 1994;65(3):172-6.
1994: Caron H; van Sluis P; van Roy N; Beks L; Maes P; Pereira do Tanque R; Slater R; de Kraker J; Speleman F; Voûte P A
Chromosome 1p allelic loss in neuroblastoma: prognosis, genomic imprinting and 1;17 translocations.
Progress in clinical and biological research 1994;385():35-42.
1994: Vereecken G; Leroy B; Speleman F; Hanssens M; Meire F
Ocular anomalies in an unbalanced translocation between chromosomes 7 and 8.
Bulletin de la Société belge d'ophtalmologie 1994;254():147-55.
1993: Van Roy N; Laureys G; Versteeg R; Opdenakker G; Speleman F
High-resolution fluorescence mapping of 46 DNA markers to the short arm of human chromosome 1.
Genomics 1993;18(1):71-8.
1993: Speleman F; Van Roy N; De Vos E; Hilliker C; Suijkerbuijk R F; Leroy J G
Molecular cytogenetic analysis of a familial pericentric inversion of chromosome 12.
Clinical genetics 1993;44(3):156-63.
1993: Verschraegen-Spae M R; van Roy N; de Perdigo A; de Paepe A; Speleman F
Molecular cytogenetic characterization of marker chromosomes found at prenatal diagnosis.
Prenatal diagnosis 1993;13(5):385-94.
1993: van Roy N; Mangelschots K; Speleman F
Improved immunocytochemical detection of biotinylated probes with Neutralite avidin.
Trends in genetics : TIG 1993;9(3):71-2.
1993: Hoovers J M; Redeker E; Speleman F; Höppener J W; Bhola S; Bliek J; van Roy N; Leschot N J; Westerveld A; Mannens M
High-resolution chromosomal localization of the human calcitonin/CGRP/IAPP gene family members.
Genomics 1993;15(3):525-9.
1992: Speleman F; Colpaert C; Goovaerts G; Leroy J G; Van Marck E
Malignant melanoma of soft parts. Further cytogenetic characterization.
Cancer genetics and cytogenetics 1992;60(2):176-9.
1992: Mangelschots K; Van Roy B; Speleman F; Van Roy N; Gheuens J; Beuten J; Buntinx I; Van Thienen M N; Willekens H; Dumon J
Reciprocal translocation between the proximal regions of the long arms of chromosomes 13 and 15 resulting in unbalanced offspring: characterization by fluorescence in situ hybridization and DNA analysis.
Human genetics 1992;89(4):407-13.
1992: Van der Auwera B; Van Roy N; De Paepe A; Hawkins J R; Liebaers I; Castedo S; Dumon J; Speleman F
Molecular cytogenetic analysis of XX males using Y-specific DNA sequences, including SRY.
Human genetics 1992;89(1):23-8.
1992: Verschraegen-Spae M R; Depypere H; Speleman F; Dhondt M; De Paepe A
Familial Turner syndrome.
Clinical genetics 1992;41(4):218-20.
1992: Speleman F; Van Roy N; Wiegant J; Verschraegen-Spae M R; Benoit Y; Govaert P; Goossens L; Leroy J G
Detection of subtle reciprocal translocations by fluorescence in situ hybridization.
Clinical genetics 1992;41(4):169-74.
1992: Speleman F; Van Roy N; Wiegant J; Dierick A M; Uyttendaele D; Leroy J G
Molecular cytogenetic analysis of a complex t(10;22;11) translocation in Ewing's sarcoma.
Genes, chromosomes & cancer 1992;4(2):188-91.
1991: Speleman F; Leroy J G; Van Roy N; De Paepe A; Suijkerbuijk R; Brunner H; Looijenga L; Verschraegen-Spae M R; Orye E
Pallister-Killian syndrome: characterization of the isochromosome 12p by fluorescent in situ hybridization.
American journal of medical genetics 1991;41(3):381-7.
1991: Speleman F; Dal Cin P; Van Roy N; Van Marck E; Buytaert P; Van den Berghe H; Leroy J G
Is t(6;20)(p21;q13) a characteristic chromosome change in endometrial polyps?
Genes, chromosomes & cancer 1991;3(4):318-9.
1991: Speleman F; Mannens M; Redeker B; Vercruyssen M; Van Oostveldt P; Leroy J; Slater R
Characterization of a de novo duplication of 11p14----p13, using fluorescent in situ hybridization and southern hybridization.
Cytogenetics and cell genetics 1991;56(3-4):129-31.
1991: Speleman F; Mangelschots K; Vercruyssen M; Dal Cin P; Aventin A; Offner F; Laureys G; Van den Berghe H; Leroy J
Analysis of whole-arm translocations in malignant blood cells by nonisotopic in situ hybridization.
Cytogenetics and cell genetics 1991;56(1):14-7.
1991: Coucke P; Mangelschots K; Speleman F; Bossuyt P; Van Oostveldt P; Van der Auwera B; Carritt B; Willems P J
Assignment of the fucosidase pseudogene FUCA1P to chromosome region 2q31----q32.
Cytogenetics and cell genetics 1991;57(2-3):120-2.
1990: Speleman F; Van der Auwera B; Mangelschots K; Vercruyssen M; Raap T; Wiegant J; Craen M; Leroy J
Identification and characterization of normal length nonfluorescent Y chromosomes: cytogenetic analysis, southern hybridization and non-isotopic in situ hybridization.
Human genetics 1990;85(6):569-75.
1990: Laureys G; Speleman F; Opdenakker G; Benoit Y; Leroy J
Constitutional translocation t(1;17)(p36;q12-21) in a patient with neuroblastoma.
Genes, chromosomes & cancer 1990;2(3):252-4.
1990: Speleman F; De Potter C; Dal Cin P; Mangelschots K; Ingelaere H; Laureys G; Benoit Y; Leroy J; Van Den Berghe H
i(12p) in a malignant ovarian tumor.
Cancer genetics and cytogenetics 1990;45(1):49-53.
1989: Speleman F; Craen M; Leroy J
De novo terminal deletion 7p22.1--pter in a child without craniosynostosis.
Journal of medical genetics 1989;26(8):528-32.
1989: Speleman F; De Telder V; De Potter K R; Dal Cin P; Van Daele S; Benoit Y; Leroy J G; Van den Berghe H
Cytogenetic analysis of a mesenchymal hamartoma of the liver.
Cancer genetics and cytogenetics 1989;40(1):29-32.
1989: Speleman F; Dal Cin P; De Potter K; Laureys G; Roels H J; Leroy J; Van Den Berghe H
Cytogenetic investigation of a case of congenital fibrosarcoma.
Cancer genetics and cytogenetics 1989;39(1):21-4.

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