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Thomas Spelsberg

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
51
Riggs, Lawrence B.
46
Subramaniam, Malayannan
25
Khosla, Sundeep
17
Oursler, Merry Jo
14
Rickard, David
14
Monroe, David
11
Rajamannan, Nalini
10
Johnsen, Steven
10
Turner, Russell
9
Landers, JP
9
Hawse, John
7
Hefferan, Theresa
6
Hofbauer, Lorenz
6
Bonow, Robert
6
Waters, Katrina

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Publications

TOP 3
Wu Xianglin; Hawse John R; Subramaniam Malayannan; Goetz Matthew P; Ingle James N; Spelsberg Thomas C
The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells.
Zhang Ying; Hassan Mohammad Q; Xie Rong-Lin; Hawse John R; Spelsberg Thomas C; Montecino Martin; Stein Janet L; Lian Jane B; van Wijnen Andre J; Stein Gary S
Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats).
Shin Sook; Bosc Denis G; Ingle James N; Spelsberg Thomas C; Janknecht Ralf
Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors.

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All Publications

2009: Wu Xianglin; Hawse John R; Subramaniam Malayannan; Goetz Matthew P; Ingle James N; Spelsberg Thomas C
The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells.
Cancer research 2009;69(5):1722-7.
2009: Zhang Ying; Hassan Mohammad Q; Xie Rong-Lin; Hawse John R; Spelsberg Thomas C; Montecino Martin; Stein Janet L; Lian Jane B; van Wijnen Andre J; Stein Gary S
Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats).
The Journal of biological chemistry 2009;284(5):3125-35.
2008: Shin Sook; Bosc Denis G; Ingle James N; Spelsberg Thomas C; Janknecht Ralf
Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors.
Journal of cellular biochemistry 2008;105(3):866-74.
2008: Hawse John R; Subramaniam Malayannan; Monroe David G; Hemmingsen Amanda H; Ingle James N; Khosla Sundeep; Oursler Merry Jo; Spelsberg Thomas C
Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain.
Molecular endocrinology (Baltimore, Md.) 2008;22(7):1579-95.
2008: Hawse J R; Iwaniec U T; Bensamoun S F; Monroe D G; Peters K D; Ilharreborde B; Rajamannan N M; Oursler M J; Turner R T; Spelsberg T C; Subramaniam M
TIEG-null mice display an osteopenic gender-specific phenotype.
Bone 2008;42(6):1025-31.
2008: Rickard David J; Iwaniec Urszula T; Evans Glenda; Hefferan Theresa E; Hunter Jamie C; Waters Katrina M; Lydon John P; O'Malley Bert W; Khosla Sundeep; Spelsberg Thomas C; Turner Russell T
Bone growth and turnover in progesterone receptor knockout mice.
Endocrinology 2008;149(5):2383-90.
2008: Mödder U I; Sanyal A; Xu J; O'Malley B W; Spelsberg T C; Khosla S
The skeletal response to estrogen is impaired in female but not in male steroid receptor coactivator (SRC)-1 knock out mice.
Bone 2008;42(2):414-21.
2008: Rudnik Volha; Sanyal Arunik; Syed Farhan A; Monroe David G; Spelsberg Thomas C; Oursler Merry Jo; Khosla Sundeep
Loss of ERE binding activity by estrogen receptor-alpha alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells.
Journal of cellular biochemistry 2008;103(3):896-907.
2008: Hawse J R; Subramaniam M; Ingle J N; Oursler M J; Rajamannan N M; Spelsberg T C
Estrogen-TGFbeta cross-talk in bone and other cell types: role of TIEG, Runx2, and other transcription factors.
Journal of cellular biochemistry 2008;103(2):383-92.
2007: Subramaniam Malayannan; Hawse John R; Johnsen Steven A; Spelsberg Thomas C
Role of TIEG1 in biological processes and disease states.
Journal of cellular biochemistry 2007;102(3):539-48.
2007: Secreto Frank J; Monroe David G; Dutta Shamit; Ingle James N; Spelsberg Thomas C
Estrogen receptor alpha/beta isoforms, but not betacx, modulate unique patterns of gene expression and cell proliferation in Hs578T cells.
Journal of cellular biochemistry 2007;101(5):1125-47.
2007: Syed Farhan A; Fraser Daniel G; Spelsberg Thomas C; Rosen Clifford J; Krust Andree; Chambon Pierre; Jameson J Larry; Khosla Sundeep
Effects of loss of classical estrogen response element signaling on bone in male mice.
Endocrinology 2007;148(4):1902-10.
2007: Rajamannan Nalini M; Subramaniam Malayannan; Abraham Theodore P; Vasile Vlad C; Ackerman Michael J; Monroe David G; Chew Teng-Leong; Spelsberg Thomas C
TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway.
Journal of cellular biochemistry 2007;100(2):315-25.
2006: Bensamoun Sabine F; Hawse John R; Subramaniam Malayannan; Ilharreborde Brice; Bassillais Armelle; Benhamou Claude L; Fraser Daniel G; Oursler Merry J; Amadio Peter C; An Kai-Nan; Spelsberg Thomas C
TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture.
Bone 2006;39(6):1244-51.
2006: Bensamoun Sabine F; Tsubone Tetsu; Subramaniam Malayannan; Hawse John R; Boumediene Emir; Spelsberg Thomas C; An Kai-Nan; Amadio Peter C
Age-dependent changes in the mechanical properties of tail tendons in TGF-beta inducible early gene-1 knockout mice.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;101(5):1419-24.
2006: Monroe David G; Secreto Frank J; Hawse John R; Subramaniam Malayannan; Khosla Sundeep; Spelsberg Thomas C
Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements.
The Journal of biological chemistry 2006;281(39):28596-604.
2006: Maran A; Shogren K; Zhang M; Yaszemski M J; Hefferan T E; Spelsberg T C; Kloosterboer H J; Turner R T
Effects of stable transfection of human fetal osteoblast cells with estrogen receptor-alpha on regulation of gene expression by tibolone.
Bone 2006;39(3):523-9.
2006: Caira Frank C; Stock Stuart R; Gleason Thomas G; McGee Edwin C; Huang Jie; Bonow Robert O; Spelsberg Thomas C; McCarthy Patrick M; Rahimtoola Shahbudin H; Rajamannan Nalini M
Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation.
Journal of the American College of Cardiology 2006;47(8):1707-12.
2005: Syed Farhan A; Mödder Ulrike I L; Fraser Daniel G; Spelsberg Thomas C; Rosen Clifford J; Krust Andree; Chambon Pierre; Jameson J Larry; Khosla Sundeep
Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(11):1992-2001.
2005: Effenberger Katharina E; Johnsen Steven A; Monroe David G; Spelsberg Thomas C; Westendorf Johannes J
Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens.
The Journal of steroid biochemistry and molecular biology 2005;96(5):387-99.
2005: Rajamannan Nalini M; Subramaniam Malayannan; Caira Frank; Stock Stuart R; Spelsberg Thomas C
Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway.
Circulation 2005;112(9 Suppl):I229-34.
2005: Rajamannan Nalini M; Nealis Thomas B; Subramaniam Malayannan; Pandya Sanjay; Stock Stuart R; Ignatiev Constatine I; Sebo Thomas J; Rosengart Todd K; Edwards William D; McCarthy Patrick M; Bonow Robert O; Spelsberg Thomas C
Calcified rheumatic valve neoangiogenesis is associated with vascular endothelial growth factor expression and osteoblast-like bone formation.
Circulation 2005;111(24):3296-301.
2005: Rajamannan N M; Subramaniam M; Stock S R; Stone N J; Springett M; Ignatiev K I; McConnell J P; Singh R J; Bonow R O; Spelsberg T C
Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve.
Heart (British Cardiac Society) 2005;91(6):806-10.
2005: Monroe David G; Secreto Frank J; Subramaniam Malayannan; Getz Barbara J; Khosla Sundeep; Spelsberg Thomas C
Estrogen receptor alpha and beta heterodimers exert unique effects on estrogen- and tamoxifen-dependent gene expression in human U2OS osteosarcoma cells.
Molecular endocrinology (Baltimore, Md.) 2005;19(6):1555-68.
2005: Makkena Babu; Salti Hani; Subramaniam Malayannan; Thennapan Senthil; Bonow Robert H; Caira Frank; Bonow Robert O; Spelsberg Thomas C; Rajamannan Nalini M
Atorvastatin decreases cellular proliferation and bone matrix expression in the hypercholesterolemic mitral valve.
Journal of the American College of Cardiology 2005;45(4):631-3.
2005: Dowdy Sean C; Mariani Andrea; Reinholz Monica M; Keeney Gary L; Spelsberg Thomas C; Podratz Karl C; Janknecht Ralf
Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer.
Gynecologic oncology 2005;96(2):368-73.
2005: Subramaniam Malayannan; Gorny Genevieve; Johnsen Steven A; Monroe David G; Evans Glenda L; Fraser Daniel G; Rickard David J; Rasmussen Kay; van Deursen Jan M A; Turner Russell T; Oursler Merry Jo; Spelsberg Thomas C
TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro.
Molecular and cellular biology 2005;25(3):1191-9.
2005: Sanyal A; Riggs B L; Spelsberg T C; Khosla S
Bone marrow stromal cells express two distinct splice variants of ER-alpha that are regulated by estrogen.
Journal of cellular biochemistry 2005;94(1):88-97.
2005: Kennedy Angela M; Shogren Kristen L; Zhang Minzhi; Turner Russell T; Spelsberg Thomas C; Maran Avudaiappan
17beta-estradiol-dependent activation of signal transducer and activator of transcription-1 in human fetal osteoblasts is dependent on Src kinase activity.
Endocrinology 2005;146(1):201-7.
2004: Modder Ulrike I L; Riggs B Lawrence; Spelsberg Thomas C; Fraser Daniel G; Atkinson Elizabeth J; Arnold Rudolf; Khosla Sundeep
Dose-response of estrogen on bone versus the uterus in ovariectomized mice.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151(4):503-10.
2004: Reinholz Monica M; An Ming-Wen; Johnsen Steven A; Subramaniam Malayannan; Suman Vera J; Ingle James N; Roche Patrick C; Spelsberg Thomas C
Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.
Breast cancer research and treatment 2004;86(1):75-88.
2004: Tefferi Ayalew; Spelsberg Thomas C
Primer on medical genomics. The end of the beginning.
Mayo Clinic proceedings. Mayo Clinic 2004;79(5):659-60.
2004: Mödder Ulrike I L; Sanyal Arunik; Kearns Ann E; Sibonga Jean D; Nishihara Eijun; Xu Jianming; O'Malley Bert W; Ritman Erik L; Riggs B Lawrence; Spelsberg Thomas C; Khosla Sundeep
Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice.
Endocrinology 2004;145(2):913-21.
2003: Monroe D G; Secreto F J; Spelsberg T C
Overview of estrogen action in osteoblasts: role of the ligand, the receptor, and the co-regulators.
Journal of musculoskeletal & neuronal interactions 2003;3(4):357-62; discussion 381.
2003: Chen George G; Xu Hu; Lee Janet F Y; Subramaniam Malayannan; Leung Ka L; Wang Su H; Chan Ursula P F; Spelsberg Thomas C
15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway.
International journal of cancer. Journal international du cancer 2003;107(5):837-43.
2003: Monroe David G; Getz Barbara J; Johnsen Steven A; Riggs B Lawrence; Khosla Sundeep; Spelsberg Thomas C
Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta.
Journal of cellular biochemistry 2003;90(2):315-26.
2003: Rajamannan Nalini M; Edwards William D; Spelsberg Thomas C
Hypercholesterolemic aortic-valve disease.
The New England journal of medicine 2003;349(7):717-8.
2003: Carley Michael E; Rickard David J; Gebhart John B; Webb Maurice J; Podratz Karl C; Spelsberg Thomas C
Distribution of estrogen receptors alpha and beta mRNA in mouse urogenital tissues and their expression after oophorectomy and estrogen replacement.
International urogynecology journal and pelvic floor dysfunction 2003;14(2):141-5.
2003: Rickard D J; Monroe D G; Ruesink T J; Khosla S; Riggs B L; Spelsberg T C
Phytoestrogen genistein acts as an estrogen agonist on human osteoblastic cells through estrogen receptors alpha and beta.
Journal of cellular biochemistry 2003;89(3):633-46.
2003: Rajamannan Nalini M; Subramaniam Malayannan; Rickard David; Stock Stuart R; Donovan Janis; Springett Margaret; Orszulak Thomas; Fullerton David A; Tajik A J; Bonow Robert O; Spelsberg Thomas
Human aortic valve calcification is associated with an osteoblast phenotype.
Circulation 2003;107(17):2181-4.
2003: Monroe D G; Johnsen S A; Subramaniam M; Getz B J; Khosla S; Riggs B L; Spelsberg T C
Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines.
The Journal of endocrinology 2003;176(3):349-57.
2003: Monroe D G; Spelsberg T C
A case for estrogen receptors on cell membranes and nongenomic actions of estrogen.
Calcified tissue international 2003;72(3):183-4.
2003: Shui Chaoxiang; Spelsberg Thomas C; Riggs B Lawrence; Khosla Sundeep
Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(2):213-21.
2002: Pardanani Animesh; Wieben Eric D; Spelsberg Thomas C; Tefferi Ayalew
Primer on medical genomics. Part IV: Expression proteomics.
Mayo Clinic proceedings. Mayo Clinic 2002;77(11):1185-96.
2002: Tefferi Ayalew; Bolander Mark E; Ansell Stephen M; Wieben Eric D; Spelsberg Thomas C
Primer on medical genomics. Part III: Microarray experiments and data analysis.
Mayo Clinic proceedings. Mayo Clinic 2002;77(9):927-40.
2002: Tefferi Ayalew; Wieben Eric D; Dewald Gordon W; Whiteman David A H; Bernard Matthew E; Spelsberg Thomas C
Primer on medical genomics part II: Background principles and methods in molecular genetics.
Mayo Clinic proceedings. Mayo Clinic 2002;77(8):785-808.
2002: Johnsen Steven A; Subramaniam Malayannan; Janknecht Ralf; Spelsberg Thomas C
TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.
Oncogene 2002;21(37):5783-90.
2002: Johnsen Steven A; Subramaniam Malayannan; Monroe David G; Janknecht Ralf; Spelsberg Thomas C
Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue.
The Journal of biological chemistry 2002;277(34):30754-9.
2002: Carley Michael E; Cliby William A; Spelsberg Thomas C
P2X(3) receptor subunit messenger RNA expression in the female mouse bladder after oophorectomy with or without estrogen replacement.
American journal of obstetrics and gynecology 2002;187(1):103-6.
2002: Rajamannan Nalini M; Subramaniam Malayannan; Springett Margaret; Sebo Thomas C; Niekrasz Marek; McConnell Joseph P; Singh Ravinder J; Stone Neil J; Bonow Robert O; Spelsberg Thomas C
Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve.
Circulation 2002;105(22):2660-5.
2002: Rickard David J; Waters Katrina M; Ruesink Terry J; Khosla Sundeep; Katzenellenbogen John A; Katzenellenbogen Benita S; Riggs B Lawrence; Spelsberg Thomas C
Estrogen receptor isoform-specific induction of progesterone receptors in human osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(4):580-92.
2002: Reinholz Gregory G; Getz Barbara; Sanders Emily S; Karpeisky Marat Ya; Padyukova Nelly Sh; Mikhailov Sergey N; Ingle James N; Spelsberg Thomas C
Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue.
Breast cancer research and treatment 2002;71(3):257-68.
2002: Maran A; Zhang M; Kennedy A M; Sibonga J D; Rickard D J; Spelsberg T C; Turner R T
2-methoxyestradiol induces interferon gene expression and apoptosis in osteosarcoma cells.
Bone 2002;30(2):393-8.
2002: Johnsen Steven A; Subramaniam Malayannan; Katagiri Takenobu; Janknecht Ralf; Spelsberg Thomas C
Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene.
Journal of cellular biochemistry 2002;87(2):233-41.
2002: Subramaniam M; Jalal Syed M; Rickard David J; Harris Steven A; Bolander Mark E; Spelsberg Thomas C
Further characterization of human fetal osteoblastic hFOB 1.19 and hFOB/ER alpha cells: bone formation in vivo and karyotype analysis using multicolor fluorescent in situ hybridization.
Journal of cellular biochemistry 2002;87(1):9-15.
2001: Gebhart J B; Rickard D J; Barrett T J; Lesnick T G; Webb M J; Podratz K C; Spelsberg T C
Expression of estrogen receptor isoforms alpha and beta messenger RNA in vaginal tissue of premenopausal and postmenopausal women.
American journal of obstetrics and gynecology 2001;185(6):1325-30; discussion 1330-1.
2001: Waters K M; Rickard D J; Riggs B L; Khosla S; Katzenellenbogen J A; Katzenellenbogen B S; Moore J; Spelsberg T C
Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform.
Journal of cellular biochemistry 2001;83(3):448-62.
2001: Maran A; Zhang M; Spelsberg T C; Turner R T
The dose-response effects of ethanol on the human fetal osteoblastic cell line.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(2):270-6.
2001: Hofbauer L C; Shui C; Riggs B L; Dunstan C R; Spelsberg T C; O'Brien T; Khosla S
Effects of immunosuppressants on receptor activator of NF-kappaB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells.
Biochemical and biophysical research communications 2001;280(1):334-9.
2000: Gori F; Hofbauer L C; Dunstan C R; Spelsberg T C; Khosla S; Riggs B L
The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated.
Endocrinology 2000;141(12):4768-76.
2000: Reinholz G G; Getz B; Pederson L; Sanders E S; Subramaniam M; Ingle J N; Spelsberg T C
Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts.
Cancer research 2000;60(21):6001-7.
2000: Hefferan T E; Reinholz G G; Rickard D J; Johnsen S A; Waters K M; Subramaniam M; Spelsberg T C
Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells.
The Journal of biological chemistry 2000;275(27):20255-9.
2000: Hefferan T E; Subramaniam M; Khosla S; Riggs B L; Spelsberg T C
Cytokine-specific induction of the TGF-beta inducible early gene (TIEG): regulation by specific members of the TGF-beta family.
Journal of cellular biochemistry 2000;78(3):380-90.
2000: Harris S A; Zhang M; Kidder L S; Evans G L; Spelsberg T C; Turner R T
Effects of orbital spaceflight on human osteoblastic cell physiology and gene expression.
Bone 2000;26(4):325-31.
2000: Robinson J A; Waters K M; Turner R T; Spelsberg T C
Direct action of naturally occurring estrogen metabolites on human osteoblastic cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(3):499-506.
1999: Pederson L; Winding B; Foged N T; Spelsberg T C; Oursler M J
Identification of breast cancer cell line-derived paracrine factors that stimulate osteoclast activity.
Cancer research 1999;59(22):5849-55.
1999: Thomas T; Gori F; Spelsberg T C; Khosla S; Riggs B L; Conover C A
Response of bipotential human marrow stromal cells to insulin-like growth factors: effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes.
Endocrinology 1999;140(11):5036-44.
1999: Hofbauer L C; Gori F; Riggs B L; Lacey D L; Dunstan C R; Spelsberg T C; Khosla S
Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis.
Endocrinology 1999;140(10):4382-9.
1999: Hofbauer L C; Lacey D L; Dunstan C R; Spelsberg T C; Riggs B L; Khosla S
Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells.
Bone 1999;25(3):255-9.
1999: Gori F; Thomas T; Hicok K C; Spelsberg T C; Riggs B L
Differentiation of human marrow stromal precursor cells: bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(9):1522-35.
1999: Hofbauer L C; Khosla S; Dunstan C R; Lacey D L; Spelsberg T C; Riggs B L
Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells.
Endocrinology 1999;140(9):4367-70.
1999: Spelsberg T C; Subramaniam M; Riggs B L; Khosla S
The actions and interactions of sex steroids and growth factors/cytokines on the skeleton.
Molecular endocrinology (Baltimore, Md.) 1999;13(6):819-28.
1999: Pederson L; Kremer M; Judd J; Pascoe D; Spelsberg T C; Riggs B L; Oursler M J
Androgens regulate bone resorption activity of isolated osteoclasts in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(2):505-10.
1999: Rickard D J; Subramaniam M; Spelsberg T C
Molecular and cellular mechanisms of estrogen action on the skeleton.
Journal of cellular biochemistry 1999;Suppl 32-33():123-32.
1999: Barrett T J; Spelsberg T C
Nuclear matrix and steroid hormone action.
Vitamins and hormones 1999;55():127-63.
1998: Fautsch M P; Vrabel A; Rickard D; Subramaniam M; Spelsberg T C; Wieben E D
Characterization of the mouse TGFbeta-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcripts.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(10):838-42.
1998: Hofbauer L C; Dunstan C R; Spelsberg T C; Riggs B L; Khosla S
Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines.
Biochemical and biophysical research communications 1998;250(3):776-81.
1998: Fautsch M P; Vrabel A; Subramaniam M; Hefferen T E; Spelsberg T C; Wieben E D
TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters.
Genomics 1998;51(3):408-16.
1998: Tau K R; Hefferan T E; Waters K M; Robinson J A; Subramaniam M; Riggs B L; Spelsberg T C
Estrogen regulation of a transforming growth factor-beta inducible early gene that inhibits deoxyribonucleic acid synthesis in human osteoblasts.
Endocrinology 1998;139(3):1346-53.
1998: Hicok K C; Thomas T; Gori F; Rickard D J; Spelsberg T C; Riggs B L
Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(2):205-17.
1998: Subramaniam M; Hefferan T E; Tau K; Peus D; Pittelkow M; Jalal S; Riggs B L; Roche P; Spelsberg T C
Tissue, cell type, and breast cancer stage-specific expression of a TGF-beta inducible early transcription factor gene.
Journal of cellular biochemistry 1998;68(2):226-36.
1998: Rickard D J; Hofbauer L C; Bonde S K; Gori F; Spelsberg T C; Riggs B L
Bone morphogenetic protein-6 production in human osteoblastic cell lines. Selective regulation by estrogen.
The Journal of clinical investigation 1998;101(2):413-22.
1998: Kassem M; Okazaki R; Harris S A; Spelsberg T C; Conover C A; Riggs B L
Estrogen effects on insulin-like growth factor gene expression in a human osteoblastic cell line with high levels of estrogen receptor.
Calcified tissue international 1998;62(1):60-6.
1998: Barrett T J; Spelsberg T C
Steroid receptors at the nexus of transcriptional regulation.
Journal of cellular biochemistry. Supplement 1998;30-31():185-93.
1997: Lauber A H; Barrett T J; Subramaniam M; Schuchard M; Spelsberg T C
A DNA-binding element for a steroid receptor-binding factor is flanked by dual nuclear matrix DNA attachment sites in the c-myc gene promoter.
The Journal of biological chemistry 1997;272(39):24657-65.
1996: Rickard D J; Kassem M; Hefferan T E; Sarkar G; Spelsberg T C; Riggs B L
Isolation and characterization of osteoblast precursor cells from human bone marrow.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(3):312-24.
1996: Kassem M; Okazaki R; De León D; Harris S A; Robinson J A; Spelsberg T C; Conover C A; Riggs B L
Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4.
Proceedings of the Association of American Physicians 1996;108(2):155-64.
1996: Kassem M; Harris S A; Spelsberg T C; Riggs B L
Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(2):193-9.
1996: Robinson J A; Riggs B L; Spelsberg T C; Oursler M J
Osteoclasts and transforming growth factor-beta: estrogen-mediated isoform-specific regulation of production.
Endocrinology 1996;137(2):615-21.
1996: Spelsberg T C; Lauber A H; Sandhu N P; Subramaniam M
A nuclear matrix acceptor site for the progesterone receptor in the avian c-myc gene promoter.
Recent progress in hormone research 1996;51():63-96.
1995: Subramaniam M; Harris S A; Oursler M J; Rasmussen K; Riggs B L; Spelsberg T C
Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts.
Nucleic acids research 1995;23(23):4907-12.
1995: Harris S A; Tau K R; Enger R J; Toft D O; Riggs B L; Spelsberg T C
Estrogen response in the hFOB 1.19 human fetal osteoblastic cell line stably transfected with the human estrogen receptor gene.
Journal of cellular biochemistry 1995;59(2):193-201.
1995: Schütze N; Oursler M J; Nolan J; Riggs B L; Spelsberg T C
Zeolite A inhibits osteoclast-mediated bone resorption in vitro.
Journal of cellular biochemistry 1995;58(1):39-46.
1995: Okazaki R; Conover C A; Harris S A; Spelsberg T C; Riggs B L
Normal human osteoblast-like cells consistently express genes for insulin-like growth factors I and II but transformed human osteoblast cell lines do not.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995;10(5):788-95.
1995: Bodine P V; Riggs B L; Spelsberg T C
Regulation of c-fos expression and TGF-beta production by gonadal and adrenal androgens in normal human osteoblastic cells.
The Journal of steroid biochemistry and molecular biology 1995;52(2):149-58.
1995: Harris S A; Enger R J; Riggs B L; Spelsberg T C
Development and characterization of a conditionally immortalized human fetal osteoblastic cell line.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995;10(2):178-86.
1995: Subramaniam M; Oursler M J; Rasmussen K; Riggs B L; Spelsberg T C
TGF-beta regulation of nuclear proto-oncogenes and TGF-beta gene expression in normal human osteoblast-like cells.
Journal of cellular biochemistry 1995;57(1):52-61.
1995: Lauber A H; Sandhu N P; Schuchard M; Subramaniam M; Spelsberg T C
Nuclear matrix acceptor binding sites for steroid hormone receptors: a candidate nuclear matrix acceptor protein.
International review of cytology 1995;162B():337-76.
1995: Spelsberg T C; Harris S A; Riggs B L
Immortalized osteoblast cell systems (new human fetal osteoblast systems).
Calcified tissue international 1995;56 Suppl 1():S18-21.
1994: Oda R P; Madden B J; Morris J C; Spelsberg T C; Landers J P
Multiple-buffer-additive strategies for enhanced capillary electrophoretic separation of peptides.
Journal of chromatography. A 1994;680(1):341-51.
1994: Oursler M J; Pederson L; Fitzpatrick L; Riggs B L; Spelsberg T
Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5227-31.
1994: Landers J P; Subramaniam M; Gosse B; Weinshilboum R; Madden B J; Spelsberg T C
The ubiquitous nature of the progesterone receptor binding factor-1 (RBF-1) in avian tissues.
Journal of cellular biochemistry 1994;55(2):241-51.
1994: Backup P; Westerlind K; Harris S; Spelsberg T; Kline B; Turner R
Spaceflight results in reduced mRNA levels for tissue-specific proteins in the musculoskeletal system.
The American journal of physiology 1994;266(4 Pt 1):E567-73.
1993: Zhuang Y H; Landers J P; Schuchard M D; Syvälä H; Gosse B; Ruesink T; Spelsberg T C; Tuohimaa P
Immunohistochemical localization of the avian progesterone receptor and its candidate receptor binding factor (RBF-1).
Journal of cellular biochemistry 1993;53(4):383-93.
1993: Schuchard M; Landers J P; Sandhu N P; Spelsberg T C
Steroid hormone regulation of nuclear proto-oncogenes.
Endocrine reviews 1993;14(6):659-69.
1993: Oursler M J; Riggs B L; Spelsberg T C
Glucocorticoid-induced activation of latent transforming growth factor-beta by normal human osteoblast-like cells.
Endocrinology 1993;133(5):2187-96.
1993: Subramaniam M; Harris S A; Rasmussen K; Spelsberg T C
Rapid down-regulation of c-jun protooncogene transcription by progesterone in the avian oviduct.
Endocrinology 1993;133(5):2049-54.
1993: Landers J P; Oda R P; Liebenow J A; Spelsberg T C
Utility of high resolution capillary electrophoresis for monitoring peptide homo- and hetero-dimer formation.
Journal of chromatography. A 1993;652(1):109-17.
1993: Schuchard M; Sarkar G; Ruesink T; Spelsberg T C
Two-step "hot" PCR amplification of GC-rich avian c-myc sequences.
BioTechniques 1993;14(3):390-4.
1993: Oursler M J; Pederson L; Pyfferoen J; Osdoby P; Fitzpatrick L; Spelsberg T C
Estrogen modulation of avian osteoclast lysosomal gene expression.
Endocrinology 1993;132(3):1373-80.
1993: Landers J P; Oda R P; Spelsberg T C; Nolan J A; Ulfelder K J
Capillary electrophoresis: a powerful microanalytical technique for biologically active molecules.
BioTechniques 1993;14(1):98-111.
1992: Subramaniam M; Colvard D; Keeting P E; Rasmussen K; Riggs B L; Spelsberg T C
Glucocorticoid regulation of alkaline phosphatase, osteocalcin, and proto-oncogenes in normal human osteoblast-like cells.
Journal of cellular biochemistry 1992;50(4):411-24.
1992: Keeting P E; Oursler M J; Wiegand K E; Bonde S K; Spelsberg T C; Riggs B L
Zeolite A increases proliferation, differentiation, and transforming growth factor beta production in normal adult human osteoblast-like cells in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(11):1281-9.
1992: Turner R T; Kapelner S N; Spelsberg T C
Tissue-specific expression of bone proteins in femora of growing rats.
The American journal of physiology 1992;263(4 Pt 1):E724-9.
1992: Turner R T; Backup P; Sherman P J; Hill E; Evans G L; Spelsberg T C
Mechanism of action of estrogen on intramembranous bone formation: regulation of osteoblast differentiation and activity.
Endocrinology 1992;131(2):883-9.
1992: Landers J P; Oda R P; Madden B J; Spelsberg T C
High-performance capillary electrophoresis of glycoproteins: the use of modifiers of electroosmotic flow for analysis of microheterogeneity.
Analytical biochemistry 1992;205(1):115-24.
1992: Landers J P; Schuchard M D; Subramaniam M; Sismelich T P; Spelsberg T C
High-performance capillary electrophoretic analysis of chloramphenicol acetyl transferase activity.
Journal of chromatography 1992;603(1-2):247-57.
1992: Chaudhary L R; Spelsberg T C; Riggs B L
Production of various cytokines by normal human osteoblast-like cells in response to interleukin-1 beta and tumor necrosis factor-alpha: lack of regulation by 17 beta-estradiol.
Endocrinology 1992;130(5):2528-34.
1992: Keeting P E; Scott R E; Colvard D S; Anderson M A; Oursler M J; Spelsberg T C; Riggs B L
Development and characterization of a rapidly proliferating, well-differentiated cell line derived from normal adult human osteoblast-like cells transfected with SV40 large T antigen.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1992;7(2):127-36.
1992: Landers J P; Spelsberg T C
New concepts in steroid hormone action: transcription factors, proto-oncogenes, and the cascade model for steroid regulation of gene expression.
Critical reviews in eukaryotic gene expression 1992;2(1):19-63.
1991: Oursler M J; Cortese C; Keeting P; Anderson M A; Bonde S K; Riggs B L; Spelsberg T C
Modulation of transforming growth factor-beta production in normal human osteoblast-like cells by 17 beta-estradiol and parathyroid hormone.
Endocrinology 1991;129(6):3313-20.
1991: Rejman J; Landers J; Goldberger A; McCormick D J; Gosse B; Spelsberg T C
Purification of a nuclear protein (receptor binding factor-1) associated with the chromatin acceptor sites for the avian oviduct progesterone receptor.
Journal of protein chemistry 1991;10(6):651-67.
1991: Horton M; Landers J P; Subramaniam M; Goldberger A; Toyoda H; Gosse B; Spelsberg T C
Enrichment of a second class of native acceptor sites for the avian oviduct progesterone receptor as intact chromatin fragments.
Biochemistry 1991;30(39):9523-30.
1991: Schuchard M; Subramaniam M; Ruesink T; Spelsberg T C
Nuclear matrix localization and specific matrix DNA binding by receptor binding factor 1 of the avian oviduct progesterone receptor.
Biochemistry 1991;30(39):9516-22.
1991: Turner R T; Spelsberg T C
Correlation between mRNA levels for bone cell proteins and bone formation in long bones of maturing rats.
The American journal of physiology 1991;261(3 Pt 1):E348-53.
1991: Oursler M J; Osdoby P; Pyfferoen J; Riggs B L; Spelsberg T C
Avian osteoclasts as estrogen target cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6613-7.
1991: Keeting P E; Rifas L; Harris S A; Colvard D S; Spelsberg T C; Peck W A; Riggs B L
Evidence for interleukin-1 beta production by cultured normal human osteoblast-like cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991;6(8):827-33.
1991: Hassager C; Bonde S K; Anderson M A; Rink H; Spelsberg T C; Riggs B L
Procalcitonin NH2-terminal cleavage peptide has no mitogenic effect on normal human osteoblast-like cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991;6(5):489-93.
1991: Schuchard M; Rejman J J; McCormick D J; Gosse B; Ruesink T; Spelsberg T C
Characterization of a purified chromatin acceptor protein (receptor binding factor 1) for the avian oviduct progesterone receptor.
Biochemistry 1991;30(18):4535-42.
1991: Keeting P E; Scott R E; Colvard D S; Han I K; Spelsberg T C; Riggs B L
Lack of a direct effect of estrogen on proliferation and differentiation of normal human osteoblast-like cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991;6(3):297-304.
1991: Lau C K; Subramaniam M; Rasmussen K; Spelsberg T C
Rapid induction of the c-jun protooncogene in the avian oviduct by the antiestrogen tamoxifen.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):829-33.
1991: Landers J P; Spelsberg T C
Updates and new models for steroid hormone action.
Annals of the New York Academy of Sciences 1991;637():26-55.
1990: Lau C K; Subramaniam M; Rasmussen K; Spelsberg T C
Rapid inhibition of the c-jun proto-oncogene expression in avian oviduct by estrogen.
Endocrinology 1990;127(5):2595-7.
1990: Turner R T; Bleiberg B; Colvard D S; Keeting P E; Evans G; Spelsberg T C
Failure of isolated rat tibial periosteal cells to 5 alpha reduce testosterone to 5 alpha-dihydrotestosterone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1990;5(7):775-9.
1989: Rories C; Lau C K; Fink K; Spelsberg T C
Rapid inhibition of c-myc gene expression by a glucocorticoid in the avian oviduct.
Molecular endocrinology (Baltimore, Md.) 1989;3(6):991-1001.
1989: Colvard D S; Eriksen E F; Keeting P E; Wilson E M; Lubahn D B; French F S; Riggs B L; Spelsberg T C
Identification of androgen receptors in normal human osteoblast-like cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):854-7.
1989: Spelsberg T C; Rories C; Rejman J J; Goldberger A; Fink K; Lau C K; Colvard D S; Wiseman G
Steroid action on gene expression: possible roles of regulatory genes and nuclear acceptor sites.
Biology of reproduction 1989;40(1):54-69.
1989: Colvard D; Spelsberg T; Eriksen E; Keeting P; Riggs B L
Evidence of steroid receptors in human osteoblast-like cells.
Connective tissue research 1989;20(1-4):33-40.
1989: Rories C; Spelsberg T C
Ovarian steroid action on gene expression: mechanisms and models.
Annual review of physiology 1989;51():653-81.
1988: Spelsberg T C; Ruh T; Ruh M; Goldberger A; Horton M; Hora J; Singh R
Nuclear acceptor sites for steroid hormone receptors: comparisons of steroids and antisteroids.
Journal of steroid biochemistry 1988;31(4B):579-92.
1988: Eriksen E F; Colvard D S; Berg N J; Graham M L; Mann K G; Spelsberg T C; Riggs B L
Evidence of estrogen receptors in normal human osteoblast-like cells.
Science (New York, N.Y.) 1988;241(4861):84-6.
1988: Umehara T; Graham M L; Berg N J; Lieber M M; Spelsberg T C
A nuclear binding assay for measurement of biologically active androgen receptors in animal tissues and human prostate cancer.
Journal of steroid biochemistry 1988;31(1):15-25.
1988: Goldberger A; Spelsberg T C
Partial purification and preparation of polyclonal antibodies against candidate chromatin acceptor proteins for the avian oviduct progesterone receptor.
Biochemistry 1988;27(6):2103-9.
1988: Fink K L; Wieben E D; Woloschak G E; Spelsberg T C
Rapid regulation of c-myc protooncogene expression by progesterone in the avian oviduct.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1796-800.
1988: Colvard D S; Jankus W R; Berg N J; Graham M L; Jiang N S; Ingle J N; Spelsberg T C
Microassay for nuclear binding of steroid receptors with use of intact cells from small samples of avian and human tissue.
Clinical chemistry 1988;34(2):363-9.
1987: Goldberger A; Horton M; Katzmann J; Spelsberg T C
Characterization of the chromatin acceptor sites for the avian oviduct progesterone receptor using monoclonal antibodies.
Biochemistry 1987;26(18):5811-6.
1987: Spelsberg T C; Graham M L; Berg N J; Umehara T; Riehl E; Coulam C B; Ingle J N
A nuclear binding assay to assess the biological activity of steroid receptors in isolated animal and human tissues.
Endocrinology 1987;121(2):631-44.
1987: Spelsberg T C; Goldberger A; Horton M; Hora J
Nuclear acceptor sites for sex steroid hormone receptors in chromatin.
Journal of steroid biochemistry 1987;27(1-3):133-47.
1987: Spelsberg T C; Goldberger A; Horton M; Littlefield B; Gosse B; Rasmussen K
Monoclonal antibodies against putative nuclear acceptor sites of the avian oviduct progesterone receptor.
Advances in experimental medicine and biology 1987;230():31-48.

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