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Jonathan Spencer

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TOP 3
Manuela Tosin; Lorena Betancor; Elaine Stephens; W M Ariel Li; Jonathan B Spencer; Peter F Leadlay
Synthetic chain terminators off-load intermediates from a type I polyketide synthase.
Hai-Chen Wu; Shafida Abd Hamid; Jin-Quan Yu; Jonathan B Spencer
Possible origin of electronic effects in Rh(I)-catalyzed enantioselective hydrogenation.
Manuela Tosin; Dieter Spiteller; Jonathan B Spencer
Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates.

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All Publications

2010: Manuela Tosin; Lorena Betancor; Elaine Stephens; W M Ariel Li; Jonathan B Spencer; Peter F Leadlay
Synthetic chain terminators off-load intermediates from a type I polyketide synthase.
Chembiochem : a European journal of chemical biology 2010;11(4):539-46.
2009: Hai-Chen Wu; Shafida Abd Hamid; Jin-Quan Yu; Jonathan B Spencer
Possible origin of electronic effects in Rh(I)-catalyzed enantioselective hydrogenation.
Journal of the American Chemical Society 2009;131(28):9604-5.
2009: Manuela Tosin; Dieter Spiteller; Jonathan B Spencer
Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates.
Chembiochem : a European journal of chemical biology 2009;10(10):1714-23.
2009: Andrew W Truman; Marcio V B Dias; Shu Wu; Tom L Blundell; Fanglu Huang; Jonathan B Spencer
Chimeric glycosyltransferases for the generation of hybrid glycopeptides.
Chemistry & biology 2009;16(6):676-85.
2008: Andrew N Holding; Jonathan B Spencer
Investigation into the mechanism of phenolic couplings during the biosynthesis of glycopeptide antibiotics.
Chembiochem : a European journal of chemical biology 2008;9(14):2209-14.
2008: Qingzhi Fan; Fanglu Huang; Peter F Leadlay; Jonathan B Spencer
The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase.
Organic & biomolecular chemistry 2008;6(18):3306-14.
2008: Nicholas M Llewellyn; Jonathan B Spencer
Chemoenzymatic acylation of aminoglycoside antibiotics.
Chemical communications (Cambridge, England) 2008;(32):3786-8.
2008: Yuliya Demydchuk; Yuhui Sun; Hui Hong; James Staunton; Jonathan B Spencer; Peter F Leadlay
Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic.
Chembiochem : a European journal of chemical biology 2008;9(7):1136-45.
2008: Andrew W Truman; Qingzhi Fan; Marlene Röttgen; Evi Stegmann; Peter F Leadlay; Jonathan B Spencer
The role of cep15 in the biosynthesis of chloroeremomycin: reactivation of an ancestral catalytic function.
Chemistry & biology 2008;15(5):476-84.
2008: Lucky Tran; Manuela Tosin; Jonathan B Spencer; Peter F Leadlay; Kira J Weissman
Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases.
Chembiochem : a European journal of chemical biology 2008;9(6):905-15.
2008: Yuhui Sun; Hui Hong; Fraser Gillies; Jonathan B Spencer; Peter F Leadlay
Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics.
Chembiochem : a European journal of chemical biology 2008;9(1):150-6.
2008: Hui Hong; Dieter Spiteller; Jonathan B Spencer
Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization.
Angewandte Chemie (International ed. in English) 2008;47(32):6028-32.
2007: Nicholas M Llewellyn; Jonathan B Spencer
Biological chemistry: enzymes line up for assembly.
Nature 2007;448(7155):755-6.
2007: Nicholas M Llewellyn; Yanyan Li; Jonathan B Spencer
Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain.
Chemistry & biology 2007;14(4):379-86.
2007: Fanglu Huang; Dieter Spiteller; Neil A Koorbanally; Yanyan Li; Nicholas M Llewellyn; Jonathan B Spencer
Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin.
Chembiochem : a European journal of chemical biology 2007;8(3):283-8.
2007: Andrew W Truman; Fanglu Huang; Nicholas M Llewellyn; Jonathan B Spencer
Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin.
Angewandte Chemie (International ed. in English) 2007;46(9):1462-4.
2006: Nicholas M Llewellyn; Jonathan B Spencer
Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics.
Natural product reports 2006;23(6):864-74.
2006: Michael L Neidig; Christina D Brown; Michael Kavana; Oliver W Choroba; Jonathan B Spencer; Graham R Moran; Edward I Solomon
Spectroscopic and electronic structure studies of the role of active site interactions in the decarboxylation reaction of alpha-keto acid-dependent dioxygenases.
Journal of inorganic biochemistry 2006;100(12):2108-16.
2006: Andrew W Truman; Louisa Robinson; Jonathan B Spencer
Identification of a deacetylase involved in the maturation of teicoplanin.
Chembiochem : a European journal of chemical biology 2006;7(11):1670-5.
2006: Bojana Popovic; Xiao Tang; Dimitri Y Chirgadze; Fanglu Huang; Tom L Blundell; Jonathan B Spencer
Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis.
Proteins 2006;65(1):220-30.
2006: Barbara M Harvey; Hui Hong; Michelle A Jones; Zoë A Hughes-Thomas; Rebecca M Goss; Michelle L Heathcote; Victor Martin Bolanos-Garcia; Wolfgang Kroutil; James Staunton; Peter F Leadlay; Jonathan B Spencer
Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin.
Chembiochem : a European journal of chemical biology 2006;7(9):1435-42.
2006: Michael L Neidig; Andrea Decker; Oliver W Choroba; Fanglu Huang; Michael Kavana; Graham R Moran; Jonathan B Spencer; Edward I Solomon
Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):12966-73.
2006: Andrew R Gallimore; Jonathan B Spencer
Stereochemical uniformity in marine polyether ladders--implications for the biosynthesis and structure of maitotoxin.
Angewandte Chemie (International ed. in English) 2006;45(27):4406-13.
2006: Helen M O'Hare; Fanglu Huang; Andrew Holding; Oliver W Choroba; Jonathan B Spencer
Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution.
FEBS letters 2006;580(14):3445-50.
2006: Fanglu Huang; Stephen F Haydock; Dieter Spiteller; Tatiana Mironenko; Tsung-Lin Li; David O'Hagan; Peter F Leadlay; Jonathan B Spencer
The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A.
Chemistry & biology 2006;13(5):475-84.
2006: Andrew R Gallimore; Christian B W Stark; Apoorva Bhatt; Barbara M Harvey; Yuliya Demydchuk; Victor Martin Bolanos-Garcia; Daniel J Fowler; James Staunton; Peter F Leadlay; Jonathan B Spencer
Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis.
Chemistry & biology 2006;13(4):453-60.
2006: Helen M O'Hare; Abel Baerga-Ortiz; Bojana Popovic; Jonathan B Spencer; Peter F Leadlay
High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase.
Chemistry & biology 2006;13(3):287-96.
2006: Abel Baerga-Ortiz; Bojana Popovic; Alexandros P Siskos; Helen M O'Hare; Dieter Spiteller; Mark G Williams; Nuria Campillo; Jonathan B Spencer; Peter F Leadlay
Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.
Chemistry & biology 2006;13(3):277-85.
2006: Hai Deng; Steven L Cobb; Andrew R McEwan; Ryan P McGlinchey; James H Naismith; David O'Hagan; David A Robinson; Jonathan B Spencer
The fluorinase from Streptomyces cattleya is also a chlorinase.
Angewandte Chemie (International ed. in English) 2006;45(5):759-62.
2006: Joseph A Wright; Matthew J Gaunt; Jonathan B Spencer
Novel anti-Markovnikov regioselectivity in the Wacker reaction of styrenes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(3):949-55.
2005: Apoorva Bhatt; Christian B W Stark; Barbara M Harvey; Andrew R Gallimore; Yuliya Demydchuk; Jonathan B Spencer; James Staunton; Peter F Leadlay
Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked.
Angewandte Chemie (International ed. in English) 2005;44(43):7075-8.
2005: Dieter Spiteller; Claire L Waterman; Jonathan B Spencer
A method for trapping intermediates of polyketide biosynthesis with a nonhydrolyzable malonyl-coenzyme A analogue.
Angewandte Chemie (International ed. in English) 2005;44(43):7079-82.
2005: Alexandros P Siskos; Abel Baerga-Ortiz; Shilpa Bali; Viktor Stein; Hassan Mamdani; Dieter Spiteller; Bojana Popovic; Jonathan B Spencer; James Staunton; Kira J Weissman; Peter F Leadlay
Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases.
Chemistry & biology 2005;12(10):1145-53.
2005: Hui Hong; Timothy P Stinear; Paul Skelton; Jonathan B Spencer; Peter F Leadlay
Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry.
Chemical communications (Cambridge, England) 2005;(34):4306-8.
2005: Yanyan Li; Nicholas M Llewellyn; Ramesh Giri; Fanglu Huang; Jonathan B Spencer
Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway.
Chemistry & biology 2005;12(6):665-75.
2005: Fanglu Huang; Stephen F Haydock; Tatiana Mironenko; Dieter Spiteller; Yanyan Li; Jonathan B Spencer
The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine.
Organic & biomolecular chemistry 2005;3(8):1410-8.
2005: Hui Hong; Jonathan B Spencer; Jessica L Porter; Peter F Leadlay; Timothy P Stinear
A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase.
Chembiochem : a European journal of chemical biology 2005;6(4):643-8.
2004: Hai-Chen Wu; Jin-Quan Yu; Jonathan B Spencer
Stereospecific deoxygenation of phosphine oxides with retention of configuration using triphenylphosphine or triethyl phosphite as an oxygen acceptor.
Organic letters 2004;6(25):4675-8.
2004: Changjiang Dong; Fanglu Huang; Hai Deng; Christoph Schaffrath; Jonathan B Spencer; David O'Hagan; James H Naismith
Crystal structure and mechanism of a bacterial fluorinating enzyme.
Nature 2004;427(6974):561-5.
2004: Tsung-Lin Li; Fanglu Huang; Stephen F Haydock; Tatiana Mironenko; Peter F Leadlay; Jonathan B Spencer
Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.
Chemistry & biology 2004;11(1):107-19.
2003: Hui Hong; Paul J Gates; James Staunton; Timothy P Stinear; Stewart T Cole; Peter F Leadlay; Jonathan B Spencer
Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans.
Chemical communications (Cambridge, England) 2003;(22):2822-3.
2002: Fanglu Huang; Yanyan Li; Jinquan Yu; Jonathan B Spencer
Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine.
Chemical communications (Cambridge, England) 2002;(23):2860-1.
2002: Jinquan Yu; Matthew J Gaunt; Jonathan B Spencer
Convenient preparation of trans-arylalkenes via palladium(II)-catalyzed isomerization of cis-arylalkenes.
The Journal of organic chemistry 2002;67(13):4627-9.
2001: Tsung-Lin Li; Oliver W Choroba; H Hong; Dudley H Williams; Jonathan B Spencer
Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine.
Chemical communications (Cambridge, England) 2001;(20):2156-7.
2001: Matthew J Gaunt; J Yu; Jonathan B Spencer
Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation.
Chemical communications (Cambridge, England) 2001;(18):1844-5.
2001: Tsung-Lin Li; Oliver W Choroba; E H Charles; Alan Sandercock; Dudley H Williams; Jonathan B Spencer
Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics.
Chemical communications (Cambridge, England) 2001;(18):1752-3.
2001: Matthew J Gaunt; Jonathan B Spencer
Derailing the Wacker oxidation: development of a palladium-catalyzed amidation reaction.
Organic letters 2001;3(1):25-8.