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John Spencer

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TOP 3
Hee Jin Kim; Kalyani Prithiviraj; Patrick J Brennan; Nathan A Groathouse; John S Spencer
Gene expression profile and immunological evaluation of unique hypothetical unknown proteins of Mycobacterium leprae by using quantitative real-time PCR.
John S Spencer; William H Wheat; Marivic F Balagon; Patrick J Brennan; Delphi Chatterjee; Malcolm Duthie; Annemieke Geluk; Mary Jackson; Hee Jin Kim; Jade N Kurihara; Wei Li; Armi Maghanoy; Irene Mallari; Paul Saunderson; Hazel M Dockrell
Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy.
Annemieke Geluk; Hee Jin Kim; Abraham Aseffa; Sayera Banu; Yonas Bekele; Kidist Bobosha; Sang-Nae Cho; Hazel M Dockrell; Kees L M C Franken; Geraldo Pereira; Maria Cristina Vidal Pessolani; John S Spencer; Mohammad K M Uddin; Jolien J van der Ploeg-van Schip; Marcia V S B Martins; Sheikh Abdul Hadi; Tom H M Ottenhoff
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy.

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All Publications

2013: Hee Jin Kim; Kalyani Prithiviraj; Patrick J Brennan; Nathan A Groathouse; John S Spencer
Gene expression profile and immunological evaluation of unique hypothetical unknown proteins of Mycobacterium leprae by using quantitative real-time PCR.
Clinical and vaccine immunology : CVI 2013;20(2):181-90.
2012: John S Spencer; William H Wheat; Marivic F Balagon; Patrick J Brennan; Delphi Chatterjee; Malcolm Duthie; Annemieke Geluk; Mary Jackson; Hee Jin Kim; Jade N Kurihara; Wei Li; Armi Maghanoy; Irene Mallari; Paul Saunderson; Hazel M Dockrell
Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy.
Memórias do Instituto Oswaldo Cruz 2012;107 Suppl 1():79-89.
2012: Annemieke Geluk; Hee Jin Kim; Abraham Aseffa; Sayera Banu; Yonas Bekele; Kidist Bobosha; Sang-Nae Cho; Hazel M Dockrell; Kees L M C Franken; Geraldo Pereira; Maria Cristina Vidal Pessolani; John S Spencer; Mohammad K M Uddin; Jolien J van der Ploeg-van Schip; Marcia V S B Martins; Sheikh Abdul Hadi; Tom H M Ottenhoff
New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(10):4782-91.
2012: Marcia V S B Martins; Maria Cristina Vidal Pessolani; Maria A A Pontes; John S Spencer; Jolien J van der Ploeg-van Schip; Tereza J P G Bandeira; Patrick J Brennan; Fernanda M Carvalho; Luciana S Costa; Janvier P de Morais; Annemieke Geluk; Heitor S Gonçalves; Marjorie M da S Guimarães; Mariana A V B Hacker; Geraldo Pereira
Pathogen-specific epitopes as epidemiological tools for defining the magnitude of Mycobacterium leprae transmission in areas endemic for leprosy.
PLoS neglected tropical diseases 2012;6(4):e1616.
2011: Ramanuj Lahiri; Baljit Randhawa; John S Spencer; Malcolm S Duthie; Kees L M C Franken; Annemieke Geluk; James L Krahenbuhl
Development of a mouse food pad model for detection of sub clinical leprosy.
Leprosy review 2011;82(4):432-44.
2011: Annemieke Geluk; Malcolm S Duthie; John S Spencer
Postgenomic Mycobacterium leprae antigens for cellular and serological diagnosis of M. leprae exposure, infection and leprosy disease.
Leprosy review 2011;82(4):402-21.
2011: John S Spencer; Patrick J Brennan
The role of Mycobacterium leprae phenolic glycolipid I (PGL-I) in serodiagnosis and in the pathogenesis of leprosy.
Leprosy review 2011;82(4):344-57.
2011: Maria de la Paz Santangelo; Sabine Ehrt; Petra M Gest; Mercedes Gonzalez-Juarrero; Marcelo E Guerin; Mathieu Coinçon; Racha Daher; Anne J Lenaerts; Ha Pham; Susan E Puckett; Gavin Ryan; Dirk Schnappinger; John S Spencer; Jurgen Sygusch; Michel Therisod; Mary Jackson
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
The Journal of biological chemistry 2011;286(46):40219-31.
2011: Paul Corstjens; Claudia J de Dood; Tom H M Ottenhoff; Terhi Riuttamäki; John S Spencer; Hans J Tanke; Jolien J van der Ploeg-van Schip; Krista E van Meijgaarden; Karien C Wiesmeijer; Annemieke Geluk
Lateral flow assay for simultaneous detection of cellular- and humoral immune responses.
Clinical biochemistry 2011;44(14-15):1241-6.
2011: Annemieke Geluk; Hee Jin Kim; Karin Dijkman; Kees L M C Franken; Geraldo Pereira; Maria Cristina Vidal Pessolani; John S Spencer; Susan J F van den Eeden; Louis Wilson; Tom H M Ottenhoff
ML1419c peptide immunization induces Mycobacterium leprae-specific HLA-A*0201-restricted CTL in vivo with potential to kill live mycobacteria.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1393-402.
2011: John S Spencer; Hee Jin Kim; William H Wheat; Delphi Chatterjee; Marivic V Balagon; Roland V Cellona; Esterlina V Tan; Robert Gelber; Paul Saunderson; Malcolm S Duthie; Stephen T Reece; William Burman; Robert Belknap; William R Mac Kenzie; Annemieke Geluk; Linda Oskam; Hazel M Dockrell; Patrick J Brennan
Analysis of antibody responses to Mycobacterium leprae phenolic glycolipid I, lipoarabinomannan, and recombinant proteins to define disease subtype-specific antigenic profiles in leprosy.
Clinical and vaccine immunology : CVI 2011;18(2):260-7.
2010: Jian Zhang; Delphi Chatterjee; Patrick J Brennan; John S Spencer; Avraham Liav
A modified synthesis and serological evaluation of neoglycoproteins containing the natural disaccharide of PGL-I from Mycobacterium leprae.
Bioorganic & medicinal chemistry letters 2010;20(11):3250-3.
2010: Gavin J Ryan; Donald R Hoff; Emily R Driver; Martin I Voskuil; Mercedes Gonzalez-Juarrero; Randall J Basaraba; Dean Crick; John S Spencer; Anne J Lenaerts
Multiple M. tuberculosis phenotypes in mouse and guinea pig lung tissue revealed by a dual-staining approach.
PloS one 2010;5(6):e11108.
2008: Maria Angela M Marques; Ana Gisele C Neves-Ferreira; Erika K Xavier da Silveira; Richard H Valente; Alex Chapeaurouge; Jonas Perales; Renato da Silva Bernardes; Karen M Dobos; John S Spencer; Patrick J Brennan; Maria Cristina Vidal Pessolani
Deciphering the proteomic profile of Mycobacterium leprae cell envelope.
Proteomics 2008;8(12):2477-91.
2008: Hairong Huang; Stefan Berg; John S Spencer; Danny Vereecke; Wim D'Haeze; Marcelle Holsters; Michael R McNeil
Identification of amino acids and domains required for catalytic activity of DPPR synthase, a cell wall biosynthetic enzyme of Mycobacterium tuberculosis.
Microbiology (Reading, England) 2008;154(Pt 3):736-43.
2007: Diane Ordway; David M Higgins; Joaquin Sanchez-Campillo; John S Spencer; Marcela Henao Tamayo; Marisa Harton; Ian M Orme; Mercedes Gonzalez-Juarrero
XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-gamma by CD4 T cells and participates in granuloma stability.
Journal of leukocyte biology 2007;82(5):1221-9.
2007: Marcia Valéria B S Martins; Monica C B S Lima; Nádia Cristina Duppre; Haroldo J Matos; John S Spencer; Patrick J Brennan; Euzenir N Sarno; Leila Fonseca; Geraldo Pereira; Maria Cristina Vidal Pessolani
The level of PPD-specific IFN-gamma-producing CD4+ T cells in the blood predicts the in vivo response to PPD.
Tuberculosis (Edinburgh, Scotland) 2007;87(3):202-11.
2006: Nathan A Groathouse; Amol Amin; Maria Angela M Marques; John S Spencer; Robert Gelber; Dennis L Knudson; John Belisle; Patrick J Brennan; Richard Slayden
Use of protein microarrays to define the humoral immune response in leprosy patients and identification of disease-state-specific antigenic profiles.
Infection and immunity 2006;74(11):6458-66.
2006: Libin Shi; Stefan Berg; Arwen Lee; John S Spencer; Jian Zhang; Varalakshmi D Vissa; Michael R McNeil; Kay-Hooi Khoo; Delphi Chatterjee
The carboxy terminus of EmbC from Mycobacterium smegmatis mediates chain length extension of the arabinan in lipoarabinomannan.
The Journal of biological chemistry 2006;281(28):19512-26.
2005: John S Spencer; Hazel M Dockrell; Hee Jin Kim; Maria Angela M Marques; Diana L Williams; Marcia V S B Martins; Marcio L F Martins; Monica C B S Lima; Euzenir N Sarno; Geraldo Pereira; Haroldo J Matos; Leila S Fonseca; Elizabeth P Sampaio; Tom H M Ottenhoff; Annemieke Geluk; Sang-Nae Cho; neil stoker; Stewart T Cole; Patrick J Brennan; Maria Cristina Vidal Pessolani
Identification of specific proteins and peptides in Mycobacterium leprae suitable for the selective diagnosis of leprosy.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):7930-8.
2005: Annemieke Geluk; Michel Klein; Kees L M C Franken; Krista E van Meijgaarden; Brigitte Wieles; Kelly Pereira; Samira Bührer-Sékula; Paul R Klatser; Patrick J Brennan; John S Spencer; Diana L Williams; Maria Cristina Vidal Pessolani; Elizabeth P Sampaio; Tom H M Ottenhoff
Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection.
Infection and immunity 2005;73(9):5636-44.
2005: Marc Monot; Nadine Honoré; Thierry Garnier; Romulo Araoz; Jean-Yves Coppée; Céline Lacroix; Samba Sow; John S Spencer; Richard W Truman; Diana L Williams; Robert Gelber; Marcos Virmond; Béatrice Flageul; Sang-Nae Cho; Baohong Ji; Alberto Paniz-Mondolfi; Jacinto Convit; Saroj Young; Paul E Fine; Voahangy Rasolofo; Patrick J Brennan; Stewart T Cole
On the origin of leprosy.
Science (New York, N.Y.) 2005;308(5724):1040-2.
2004: Maria Angela M Marques; Benjamin J Espinosa; Erika K Xavier da Silveira; Maria Cristina Vidal Pessolani; Alex Chapeaurouge; Jonas Perales; Karen M Dobos; John Belisle; John S Spencer; Patrick J Brennan
Continued proteomic analysis of Mycobacterium leprae subcellular fractions.
Proteomics 2004;4(10):2942-53.
2004: John S Spencer; Hee Jin Kim; Angela M Marques; Mercedes Gonzalez-Juarerro; Monica C B S Lima; Varalakshmi D Vissa; Richard W Truman; Maria Laura Gennaro; Sang-Nae Cho; Stewart T Cole; Patrick J Brennan
Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10.
Infection and immunity 2004;72(6):3161-70.
2004: Karen M Dobos; John S Spencer; Ian M Orme; John Belisle
Proteomic approaches to antigen discovery.
Methods in molecular medicine 2004;94():3-17.
2002: John S Spencer; Maria Angela M Marques; Monica C B S Lima; Ana Paula Junqueira-Kipnis; Bruce C Gregory; Richard W Truman; Patrick J Brennan
Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6.
Infection and immunity 2002;70(2):1010-3.
2001: PierNatale Brusasca; Roberto Colangeli; Konstantin P Lyashchenko; Xilin Zhao; M Vogelstein; John S Spencer; D N McMurray; Maria Laura Gennaro
Immunological characterization of antigens encoded by the RD1 region of the Mycobacterium tuberculosis genome.
Scandinavian journal of immunology 2001;54(5):448-52.
2001: S Johnson; PierNatale Brusasca; Konstantin P Lyashchenko; John S Spencer; Harald Gotten Wiker; Pablo Bifani; Elena Shashkina; Barry Kreiswirth; Morten Harboe; Neil W Schluger; Manuel J Gomez; Maria Laura Gennaro
Characterization of the secreted MPT53 antigen of Mycobacterium tuberculosis.
Infection and immunity 2001;69(9):5936-9.
2001: B A Covert; John S Spencer; Ian M Orme; John Belisle
The application of proteomics in defining the T cell antigens of Mycobacterium tuberculosis.
Proteomics 2001;1(4):574-86.
2001: Maria Angela M Marques; S Mahapatra; Euzenir N Sarno; S Santos; John S Spencer; Patrick J Brennan; Maria Cristina Vidal Pessolani
Further biochemical characterization of Mycobacterium leprae laminin-binding proteins.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 2001;34(4):463-70.
2001: Rohit K Katial; Joyce N Hershey; T Purohit-Seth; John Belisle; Patrick J Brennan; John S Spencer; Renata J M Engler
Cell-mediated immune response to tuberculosis antigens: comparison of skin testing and measurement of in vitro gamma interferon production in whole-blood culture.
Clinical and diagnostic laboratory immunology 2001;8(2):339-45.
2000: KM Samanich; Marc A Keen; Varalakshmi D Vissa; jeff harder; John S Spencer; John Belisle; Susan Zolla-Pazner; Suman Laal
Serodiagnostic potential of culture filtrate antigens of Mycobacterium tuberculosis.
Clinical and diagnostic laboratory immunology 2000;7(4):662-8.
2000: Roberto Colangeli; John S Spencer; Pablo Bifani; A Williams; Konstantin P Lyashchenko; Marc A Keen; Preston J Hill; John Belisle; Maria Laura Gennaro
MTSA-10, the product of the Rv3874 gene of Mycobacterium tuberculosis, elicits tuberculosis-specific, delayed-type hypersensitivity in guinea pigs.
Infection and immunity 2000;68(2):990-3.