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Robert Spencer

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Stress, Psychological

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TOP 3
R J Newsom; C Osterlund; Robert L Spencer; Heidi E W Day; Cher V Masini; Serge Campeau
Cannabinoid receptor type 1 antagonism significantly modulates basal and loud noise induced neural and hypothalamic-pituitary-adrenal axis responses in male Sprague-Dawley rats.
C D Osterlund; A Chadayammuri; E Jarvis; R Unnithan; M J Weiser; Robert L Spencer
Tonic, but not phasic corticosterone, constrains stress activatedextracellular-regulated-kinase 1/ 2 immunoreactivity within the hypothalamic paraventricular nucleus.
M J Weiser; C Osterlund; Robert L Spencer
Inhibitory effects of corticosterone in the hypothalamic paraventricular nucleus (PVN) on stress-induced adrenocorticotrophic hormone secretion and gene expression in the PVN and anterior pituitary.

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All Publications

2012: R J Newsom; C Osterlund; Robert L Spencer; Heidi E W Day; Cher V Masini; Serge Campeau
Cannabinoid receptor type 1 antagonism significantly modulates basal and loud noise induced neural and hypothalamic-pituitary-adrenal axis responses in male Sprague-Dawley rats.
Neuroscience 2012;204():64-73.
2011: C D Osterlund; A Chadayammuri; E Jarvis; R Unnithan; M J Weiser; Robert L Spencer
Tonic, but not phasic corticosterone, constrains stress activatedextracellular-regulated-kinase 1/ 2 immunoreactivity within the hypothalamic paraventricular nucleus.
Journal of neuroendocrinology 2011;23(12):1241-51.
2011: M J Weiser; C Osterlund; Robert L Spencer
Inhibitory effects of corticosterone in the hypothalamic paraventricular nucleus (PVN) on stress-induced adrenocorticotrophic hormone secretion and gene expression in the PVN and anterior pituitary.
Journal of neuroendocrinology 2011;23(12):1231-40.
2011: Chad Osterlund; Robert L Spencer
Corticosterone pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis activity via multiple actions that vary with time, site of action, and de novo protein synthesis.
The Journal of endocrinology 2011;208(3):311-22.
2011: Michael B Vanelzakker; Phillip R Zoladz; Joshua D Halonen; Collin R Park; Robert L Spencer; Vanessa M Thompson; David M Diamond
Influence of Pre-Training Predator Stress on the Expression of c-fos mRNA in the Hippocampus, Amygdala, and Striatum Following Long-Term Spatial Memory Retrieval.
Frontiers in behavioral neuroscience 2011;5():30.
2010: M S Weinberg; N Grissom; Evan Paul; S Bhatnagar; Steven F Maier; Robert L Spencer
Inescapable but not escapable stress leads to increased struggling behavior and basolateral amygdala c-fos gene expression in response to subsequent novel stress challenge.
Neuroscience 2010;170(1):138-48.
2010: M S Weinberg; D C Johnson; A P Bhatt; Robert L Spencer
Medial prefrontal cortex activity can disrupt the expression of stress response habituation.
Neuroscience 2010;168(3):744-56.
2010: Robert L Spencer; Michael J Weiser
TORC: a new twist on corticotropin-releasing hormone gene expression.
Endocrinology 2010;151(3):855-8.
2009: Thaddeus W W Pace; Reginald I Gaylord; Erin Jarvis; Milena Girotti; Robert L Spencer
Differential glucocorticoid effects on stress-induced gene expression in the paraventricular nucleus of the hypothalamus and ACTH secretion in the rat.
Stress (Amsterdam, Netherlands) 2009;12(5):400-11.
2009: Marc S Weinberg; Aadra P Bhatt; Milena Girotti; Cher V Masini; Heidi E W Day; Serge Campeau; Robert L Spencer
Repeated ferret odor exposure induces different temporal patterns of same-stressor habituation and novel-stressor sensitization in both hypothalamic-pituitary-adrenal axis activity and forebrain c-fos expression in the rat.
Endocrinology 2009;150(2):749-61.
2008: Michael VanElzakker; Rebecca D Fevurly; Tressa Breindel; Robert L Spencer
Environmental novelty is associated with a selective increase in Fos expression in the output elements of the hippocampal formation and the perirhinal cortex.
Learning & memory (Cold Spring Harbor, N.Y.) 2008;15(12):899-908.
2007: M S Weinberg; Milena Girotti; Robert L Spencer
Restraint-induced fra-2 and c-fos expression in the rat forebrain: relationship to stress duration.
Neuroscience 2007;150(2):478-86.
2007: David A Brown; Micah S Johnson; Casey J Armstrong; Joshua M Lynch; Nicholas M Caruso; Lindsay B Ehlers; Monika Fleshner; Robert L Spencer; Russell L Moore
Short-term treadmill running in the rat: what kind of stressor is it?
Journal of applied physiology (Bethesda, Md. : 1985) 2007;103(6):1979-85.
2007: Milena Girotti; Marc S Weinberg; Robert L Spencer
Differential responses of hypothalamus-pituitary-adrenal axis immediate early genes to corticosterone and circadian drive.
Endocrinology 2007;148(5):2542-52.
2006: A B Francis; Thaddeus W W Pace; Abigail B Ginsberg; BA Rubin; Robert L Spencer
Limited brain diffusion of the glucocorticoid receptor agonist RU28362 following i.c.v. administration: implications for i.c.v. drug delivery and glucocorticoid negative feedback in the hypothalamic-pituitary-adrenal axis.
Neuroscience 2006;141(3):1503-15.
2006: Andre Der-Avakian; Sondra T Bland; Megan J Schmid; Linda R Watkins; Robert L Spencer; Steven F Maier
The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine.
Psychoneuroendocrinology 2006;31(5):653-63.
2006: Abigail B Ginsberg; Matthew G Frank; A B Francis; BA Rubin; Kevin A O'Connor; Robert L Spencer
Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary.
Journal of neuroendocrinology 2006;18(2):129-38.
2006: Milena Girotti; Thaddeus W W Pace; R I Gaylord; BA Rubin; J P Herman; Robert L Spencer
Habituation to repeated restraint stress is associated with lack of stress-induced c-fos expression in primary sensory processing areas of the rat brain.
Neuroscience 2006;138(4):1067-81.
2005: Thaddeus W W Pace; Reginald Gaylord; Farran Topczewski; Milena Girotti; Benjamin Rubin; Robert L Spencer
Immediate-early gene induction in hippocampus and cortex as a result of novel experience is not directly related to the stressfulness of that experience.
The European journal of neuroscience 2005;22(7):1679-90.
2005: Sondra T Bland; Megan J Schmid; Andre Der-Avakian; Linda R Watkins; Robert L Spencer; Steven F Maier
Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress.
Brain research 2005;1051(1-2):90-9.
2005: Thaddeus W W Pace; Robert L Spencer
Disruption of mineralocorticoid receptor function increases corticosterone responding to a mild, but not moderate, psychological stressor.
American journal of physiology. Endocrinology and metabolism 2005;288(6):E1082-8.
2005: Andre Der-Avakian; Matthew J Will; Sondra T Bland; Terrence Deak; Kien Nguyen; Megan J Schmid; Robert L Spencer; Linda R Watkins; Steven F Maier
Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats.
Psychopharmacology 2005;179(2):409-17.
2004: R D Fevurly; Robert L Spencer
Fos expression is selectively and differentially regulated by endogenous glucocorticoids in the paraventricular nucleus of the hypothalamus and the dentate gyrus.
Journal of neuroendocrinology 2004;16(12):970-9.
2004: Kevin A O'Connor; Abigail B Ginsberg; Elena Maksimova; Julie Wieseler Frank; John D Johnson; Robert L Spencer; Serge Campeau; Linda R Watkins; Steven F Maier
Stress-induced sensitization of the hypothalamic-pituitary adrenal axis is associated with alterations of hypothalamic and pituitary gene expression.
Neuroendocrinology 2004;80(4):252-63.
2003: Abigail B Ginsberg; Serge Campeau; Heidi E W Day; Robert L Spencer
Acute glucocorticoid pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis hormone secretion and expression of corticotropin-releasing hormone hnRNA but does not affect c-fos mRNA or fos protein expression in the paraventricular nucleus of the hypothalamus.
Journal of neuroendocrinology 2003;15(11):1075-83.
2003: Kevin A O'Connor; John D Johnson; Sayamwong E Hammack; L M Brooks; Robert L Spencer; Linda R Watkins; Steven F Maier
Inescapable shock induces resistance to the effects of dexamethasone.
Psychoneuroendocrinology 2003;28(4):481-500.
2002: Brian A Kalman; Robert L Spencer
Rapid corticosteroid-dependent regulation of mineralocorticoid receptor protein expression in rat brain.
Endocrinology 2002;143(11):4184-95.
2002: John D Johnson; Kevin A O'Connor; Terrence Deak; Robert L Spencer; Linda R Watkins; Steven F Maier
Prior stressor exposure primes the HPA axis.
Psychoneuroendocrinology 2002;27(3):353-65.
2002: Melinda L Beane; Michael A Cole; Robert L Spencer; Jerry W Rudy
Neonatal handling enhances contextual fear conditioning and alters corticosterone stress responses in young rats.
Hormones and behavior 2002;41(1):33-40.
2001: Thaddeus W W Pace; Michael A Cole; Brian A Kalman; G Ward; Robert L Spencer
Acute exposure to a novel stressor further reduces the habituated corticosterone response to restraint in rats.
Stress (Amsterdam, Netherlands) 2001;4(4):319-31.
2000: Michael A Cole; Brian A Kalman; Thaddeus W W Pace; Farran Topczewski; M J Lowrey; Robert L Spencer
Selective blockade of the mineralocorticoid receptor impairs hypothalamic-pituitary-adrenal axis expression of habituation.
Journal of neuroendocrinology 2000;12(10):1034-42.
2000: Albert Moraska; Terrence Deak; Robert L Spencer; D Roth; Monika Fleshner
Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(4):R1321-9.
2000: Robert L Spencer; Brian A Kalman; CS Cotter; Terrence Deak
Discrimination between changes in glucocorticoid receptor expression and activation in rat brain using western blot analysis.
Brain research 2000;868(2):275-86.
2000: Michael A Cole; PJ Kim; Brian A Kalman; Robert L Spencer
Dexamethasone suppression of corticosteroid secretion: evaluation of the site of action by receptor measures and functional studies.
Psychoneuroendocrinology 2000;25(2):151-67.
1999: Terrence Deak; Kien Nguyen; CS Cotter; Monika Fleshner; Linda R Watkins; Steven F Maier; Robert L Spencer
Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor.
Brain research 1999;847(2):211-20.
1999: Robert L Spencer; K E Hutchison
Alcohol, aging, and the stress response.
Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 1999;23(4):272-83.
1999: Terrence Deak; Kien Nguyen; A L Ehrlich; Linda R Watkins; Robert L Spencer; Steven F Maier; Julio Licinio; Ma-Li Wong; George Chrousos; Elizabeth Webster; P W Gold
The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress.
Endocrinology 1999;140(1):79-86.
1998: PJ Kim; Michael A Cole; Brian A Kalman; Robert L Spencer
Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies.
The Journal of steroid biochemistry and molecular biology 1998;67(3):213-22.
1998: Robert L Spencer; PJ Kim; Brian A Kalman; Michael A Cole
Evidence for mineralocorticoid receptor facilitation of glucocorticoid receptor-dependent regulation of hypothalamic-pituitary-adrenal axis activity.
Endocrinology 1998;139(6):2718-26.
1998: Andrew H Miller; Robert L Spencer; Bradley D Pearce; TL Pisell; Y Azrieli; Patima Tanapat; H Moday; R Rhee; Bruce McEwen
Glucocorticoid receptors are differentially expressed in the cells and tissues of the immune system.
Cellular immunology 1998;186(1):45-54.
1998: E Ronchi; Robert L Spencer; L C Krey; Bruce S McEwen
Effects of photoperiod on brain corticosteroid receptors and the stress response in the golden hamster (Mesocricetus auratus).
Brain research 1998;780(2):348-51.
1997: Terrence Deak; J L Meriwether; Monika Fleshner; Robert L Spencer; A Abouhamze; L L Moldawer; Ruth E Grahn; Linda R Watkins; Steven F Maier
Evidence that brief stress may induce the acute phase response in rats.
The American journal of physiology 1997;273(6 Pt 2):R1998-2004.
1997: LA Galea; Bruce S McEwen; Patima Tanapat; Terrence Deak; Robert L Spencer; Firdaus S Dhabhar
Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress.
Neuroscience 1997;81(3):689-97.
1997: Andrew H Miller; Robert L Spencer; Bradley D Pearce; TL Pisell; Patima Tanapat; J J Leung; Firdaus S Dhabhar; Bruce McEwen; Christine A Biron
1996 Curt P. Richter Award. Effects of viral infection on corticosterone secretion and glucocorticoid receptor binding in immune tissues.
Psychoneuroendocrinology 1997;22(6):455-74.
1997: Brian A Kalman; PJ Kim; Michael A Cole; M S Chi; Robert L Spencer
Diazepam attenuation of restraint stress-induced corticosterone levels is enhanced by prior exposure to repeated restraint.
Psychoneuroendocrinology 1997;22(5):349-60.
1997: Firdaus S Dhabhar; Bruce S McEwen; Robert L Spencer
Adaptation to prolonged or repeated stress--comparison between rat strains showing intrinsic differences in reactivity to acute stress.
Neuroendocrinology 1997;65(5):360-8.
1997: Robert L Spencer; Bruce S McEwen
Impaired adaptation of the hypothalamic-pituitary-adrenal axis to chronic ethanol stress in aged rats.
Neuroendocrinology 1997;65(5):353-9.
1997: Bruce S McEwen; C A Biron; KW Brunson; Karen Bulloch; William Chambers; Firdaus S Dhabhar; R H Goldfarb; Richard P Kitson; Andrew H Miller; Robert L Spencer; J M Weiss
The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions.
Brain research. Brain research reviews 1997;23(1-2):79-133.
1996: Firdaus S Dhabhar; Andrew H Miller; Bruce S McEwen; Robert L Spencer
Stress-induced changes in blood leukocyte distribution. Role of adrenal steroid hormones.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1638-44.
1996: Robert L Spencer; Andrew H Miller; H Moday; Bruce S McEwen; R J Blanchard; D Caroline Blanchard; Randall R Sakai
Chronic social stress produces reductions in available splenic type II corticosteroid receptor binding and plasma corticosteroid binding globulin levels.
Psychoneuroendocrinology 1996;21(1):95-109.
1995: Monika Fleshner; Terrence Deak; Robert L Spencer; Mark Laudenslager; Linda R Watkins; Steven F Maier
A long-term increase in basal levels of corticosterone and a decrease in corticosteroid-binding globulin after acute stressor exposure.
Endocrinology 1995;136(12):5336-42.
1995: W K O'Steen; Robert L Spencer; D J Bare; Bruce S McEwen
Analysis of severe photoreceptor loss and Morris water-maze performance in aged rats.
Behavioural brain research 1995;68(2):151-8.
1995: Robert L Spencer; W K O'Steen; Bruce S McEwen
Water maze performance of aged Sprague-Dawley rats in relation to retinal morphologic measures.
Behavioural brain research 1995;68(2):139-50.
1995: Firdaus S Dhabhar; Andrew H Miller; Bruce S McEwen; Robert L Spencer
Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5511-27.
1995: J S Orange; Thais P Salazar-Mather; S M Opal; Robert L Spencer; Andrew H Miller; Bruce McEwen; Christine A Biron
Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.
The Journal of experimental medicine 1995;181(3):901-14.
1995: D Caroline Blanchard; Robert L Spencer; S M Weiss; Robert J Blanchard; Bruce S McEwen; Randall R Sakai
Visible burrow system as a model of chronic social stress: behavioral and neuroendocrine correlates.
Psychoneuroendocrinology 1995;20(2):117-34.
1995: Firdaus S Dhabhar; Andrew H Miller; Bruce S McEwen; Robert L Spencer
Differential activation of adrenal steroid receptors in neural and immune tissues of Sprague Dawley, Fischer 344, and Lewis rats.
Journal of neuroimmunology 1995;56(1):77-90.
1994: Andrew H Miller; Robert L Spencer; J hassett; C Kim; R Rhee; D Ciurea; Firdaus S Dhabhar; Bruce S McEwen; M Stein
Effects of selective type I and II adrenal steroid agonists on immune cell distribution.
Endocrinology 1994;135(5):1934-44.
1994: T Akompong; Robert L Spencer; Bruce S McEwen
Cytosolic phospholipase C activity: II. Relationship to concanavalin A-induced phosphatidylinositol-turnover in splenocytes.
Journal of cellular biochemistry 1994;56(3):409-17.
1994: T Akompong; Robert L Spencer; Bruce S McEwen
Cytosolic phospholipase C activity: I. Evidence for coupling with cytosolic guanine nucleotide-binding protein, Gi alpha.
Journal of cellular biochemistry 1994;56(3):397-408.
1994: H M Chao; Robert L Spencer; M Frankfurt; Bruce S McEwen
The effects of aging and hormonal manipulation on amyloid precursor protein APP695 mRNA expression in the rat hippocampus.
Journal of neuroendocrinology 1994;6(5):517-21.
1994: Firdaus S Dhabhar; Andrew H Miller; M Stein; Bruce S McEwen; Robert L Spencer
Diurnal and acute stress-induced changes in distribution of peripheral blood leukocyte subpopulations.
Brain, behavior, and immunity 1994;8(1):66-79.
1994: Bruce S McEwen; H Cameron; H M Chao; Elizabeth Gould; Victoria N Luine; Ana Maria Magarinos; Constantine Pavlides; Robert L Spencer; Y Watanabe; C Woolley
Resolving a mystery: progress in understanding the function of adrenal steroid receptors in hippocampus.
Progress in brain research 1994;100():149-55.
1993: Andrew H Miller; Robert L Spencer; A Husain; R Rhee; Bruce S McEwen; M Stein
Differential expression of type I adrenal steroid receptors in immune tissues is associated with tissue-specific regulation of type II receptors by aldosterone.
Endocrinology 1993;133(5):2133-40.
1993: T Akompong; Robert L Spencer; Bruce S McEwen
Glucocorticoids inhibit soluble phospholipase C activity and cytosolic guanine nucleotide regulatory protein-alpha i immunoreactivity in spleen.
Endocrinology 1993;133(5):1963-70.
1993: Robert L Spencer; Andrew H Miller; H Moday; M Stein; Bruce S McEwen
Diurnal differences in basal and acute stress levels of type I and type II adrenal steroid receptor activation in neural and immune tissues.
Endocrinology 1993;133(5):1941-50.
1993: Andrew H Miller; Robert L Spencer; Bruce McEwen; M Stein
Depression, adrenal steroids, and the immune system.
Annals of medicine 1993;25(5):481-7.
1993: Firdaus S Dhabhar; Bruce S McEwen; Robert L Spencer
Stress response, adrenal steroid receptor levels and corticosteroid-binding globulin levels--a comparison between Sprague-Dawley, Fischer 344 and Lewis rats.
Brain research 1993;616(1-2):89-98.
1992: HM Chao; Robert L Spencer; Randall R Sakai; Bruce S McEwen
The expression of growth-associated protein GAP-43 mRNA in the rat hippocampus in response to adrenalectomy and aging.
Molecular and cellular neurosciences 1992;3(6):529-35.
1992: Andrew H Miller; Robert L Spencer; M Pulera; S Kang; Bruce S McEwen; M Stein
Adrenal steroid receptor activation in rat brain and pituitary following dexamethasone: implications for the dexamethasone suppression test.
Biological psychiatry 1992;32(10):850-69.
1991: C S Woolley; Elizabeth Gould; Randall R Sakai; Robert L Spencer; Bruce S McEwen
Effects of aldosterone or RU28362 treatment on adrenalectomy-induced cell death in the dentate gyrus of the adult rat.
Brain research 1991;554(1-2):312-5.
1991: Andrew H Miller; Robert L Spencer; Robert L Trestman; C Kim; Bruce S McEwen; M Stein
Adrenal steroid receptor activation in vivo and immune function.
The American journal of physiology 1991;261(1 Pt 1):E126-31.
1991: Robert L Spencer; Andrew H Miller; M Stein; Bruce S McEwen
Corticosterone regulation of type I and type II adrenal steroid receptors in brain, pituitary, and immune tissue.
Brain research 1991;549(2):236-46.
1990: Robert L Spencer; Bruce S McEwen
Adaptation of the hypothalamic-pituitary-adrenal axis to chronic ethanol stress.
Neuroendocrinology 1990;52(5):481-9.
1990: Andrew H Miller; Robert L Spencer; M Stein; Bruce S McEwen
Adrenal steroid receptor binding in spleen and thymus after stress or dexamethasone.
The American journal of physiology 1990;259(3 Pt 1):E405-12.
1990: Robert L Spencer; E A Young; P H Choo; Bruce S McEwen
Adrenal steroid type I and type II receptor binding: estimates of in vivo receptor number, occupancy, and activation with varying level of steroid.
Brain research 1990;514(1):37-48.
1990: Bruce S McEwen; Robert L Spencer; S Chapman; J Ganem; W K O'Steen
Neuroendocrine aspects of cerebral aging.
International journal of clinical pharmacology research 1990;10(1-2):7-14.