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Bernhard Sperker

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Chemicals & Drugs

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Christiane Kunert-Keil; Bernhard Sperker; Sandra Bien; Gabriele Wolf; Markus Grube; Heyo K Kroemer
Involvement of AP-2 binding sites in regulation of human beta-glucuronidase.
Sandra Bien; Christoph A Ritter; Matthias Gratz; Bernhard Sperker; Jürgen Sonnemann; James F Beck; Heyo K Kroemer
Nuclear factor-kappaB mediates up-regulation of cathepsin B by doxorubicin in tumor cells.
Thomas Schaarschmidt; Jutta Merkord; Ulrich Adam; Eike Schroeder; Christiane Kunert-Keil; Bernhard Sperker; Bernd Drewelow; Rainer Wacke
Expression of multidrug resistance proteins in rat and human chronic pancreatitis.

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All Publications

2004: Christiane Kunert-Keil; Bernhard Sperker; Sandra Bien; Gabriele Wolf; Markus Grube; Heyo K Kroemer
Involvement of AP-2 binding sites in regulation of human beta-glucuronidase.
Naunyn-Schmiedeberg's archives of pharmacology 2004;370(5):331-9.
2004: Sandra Bien; Christoph A Ritter; Matthias Gratz; Bernhard Sperker; Jürgen Sonnemann; James F Beck; Heyo K Kroemer
Nuclear factor-kappaB mediates up-regulation of cathepsin B by doxorubicin in tumor cells.
Molecular pharmacology 2004;65(5):1092-102.
2004: Thomas Schaarschmidt; Jutta Merkord; Ulrich Adam; Eike Schroeder; Christiane Kunert-Keil; Bernhard Sperker; Bernd Drewelow; Rainer Wacke
Expression of multidrug resistance proteins in rat and human chronic pancreatitis.
Pancreas 2004;28(1):45-52.
2003: Markus Grube; Christiane Kunert-Keil; Bernhard Sperker; Heyo K Kroemer
Verapamil regulates activity and mRNA-expression of human beta-glucuronidase in HepG2 cells.
Naunyn-Schmiedeberg's archives of pharmacology 2003;368(6):463-9.
2003: Dana Dressel; Christoph A Ritter; Bernhard Sperker; Markus Grube; Thorsten Maier; Thomas Klingebiel; Werner Siegmund; James F Beck; Heyo K Kroemer
Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease.
Clinical pharmacology and therapeutics 2003;74(3):264-74.
2003: Katrin Popowski; Bernhard Sperker; Heyo K Kroemer; Ulrich John; Michael Laule; Karl Stangl; Ingolf Cascorbi
Functional significance of a hereditary adenine insertion variant in the 5'-UTR of the endothelin-1 gene.
Pharmacogenetics 2003;13(8):445-51.
2002: Christoph A Ritter; Bernhard Sperker; Markus Grube; Dana Dressel; Christiane Kunert-Keil; Heyo K Kroemer
Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expression.
British journal of pharmacology 2002;137(7):1100-6.
2002: Werner Siegmund; Karen Ludwig; Thomas Giessmann; Peter Dazert; Eike Schroeder; Bernhard Sperker; Rolf Warzok; Heyo K Kroemer; Ingolf Cascorbi
The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.
Clinical pharmacology and therapeutics 2002;72(5):572-83.
2002: Konrad Meissner; Bernhard Sperker; Christiane Karsten; Henriette Meyer Zu Schwabedissen; Ute Seeland; Michael Böhm; Sandra Bien; Peter Dazert; Christiane Kunert-Keil; Silke Vogelgesang; Rolf Warzok; Werner Siegmund; Ingolf Cascorbi; Michael Wendt; Heyo K Kroemer
Expression and localization of P-glycoprotein in human heart: effects of cardiomyopathy.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002;50(10):1351-6.
2002: Werner Siegmund; Stephan Altmannsberger; Andrea Paneitz; Ute Hecker; Michael Zschiesche; Gerd Franke; Wieland Meng; Rolf Warzok; Eike Schroeder; Bernhard Sperker; Bernd Terhaag; Ingolf Cascorbi; Heyo K Kroemer
Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition.
Clinical pharmacology and therapeutics 2002;72(3):256-64.
2002: Bernhard Sperker; Thomas E Mürdter; Janne T Backman; Peter Fritz; Heyo K Kroemer
Expression of active human beta-glucuronidase in Sf9 cells infected with recombinant baculovirus.
Life sciences 2002;71(13):1547-57.
2002: Jörn Lötsch; Bernhard Sperker; Heyo K Kroemer; Gerd Geisslinger
Verapamil decreases glucuronidase activity in the gut.
Biochemical pharmacology 2002;63(8):1575-8.
2002: Thomas E Mürdter; Godehard Friedel; Janne T Backman; Monika McClellan; Monika Schick; Manfred Gerken; Klaus Bosslet; Peter Fritz; Heikki Toomes; Heyo K Kroemer; Bernhard Sperker
Dose optimization of a doxorubicin prodrug (HMR 1826) in isolated perfused human lungs: low tumor pH promotes prodrug activation by beta-glucuronidase.
The Journal of pharmacology and experimental therapeutics 2002;301(1):223-8.
2001: Bernhard Sperker; Céline Tomkiewicz; O Burk; Robert Barouki; Heyo K Kroemer
Regulation of human beta-glucuronidase by A23187 and thapsigargin in the hepatoma cell line HepG2.
Molecular pharmacology 2001;59(2):177-82.
2000: Thomas E Mürdter; Albert Linder; Godehard Friedel; Monika McClellan; Frank Bohnenstengel; Bernhard Sperker; Heyo K Kroemer; Heikki Toomes; Lutz Freitag; Peter Fritz
[Pharmacokinetics of cyclophosphamide, adriamycin and adriamycin prodrug (HMR 1928) using an ex vivo isolated perfused human lung model (IHLP)].
Pneumologie (Stuttgart, Germany) 2000;54(11):494-8.
2000: Bernhard Sperker; U Werner; Thomas E Mürdter; C Tekkaya; Peter Fritz; Rainer Wacke; Ulrich Adam; Manfred Gerken; Bernd Drewelow; Heyo K Kroemer
Expression and function of beta-glucuronidase in pancreatic cancer: potential role in drug targeting.
Naunyn-Schmiedeberg's archives of pharmacology 2000;362(2):110-5.
1999: D R Krishna; Bernhard Sperker; Peter Fritz; Ulrich Klotz
Does pH 6 beta-galactosidase activity indicate cell senescence?
Mechanisms of ageing and development 1999;109(2):113-23.
1999: Peter Fritz; Bernhard Sperker; Thomas E Mürdter; M Späth; P Schwarzmann; H K Kroemer; M Eichelbaum; K T Kivistö
Quantitative immunohistochemical analysis of the glutathione S-transferase GSTM1: in situ phenotyping in archival material.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(7):693-702.
1999: Christoph A Ritter; Frank Bohnenstengel; ute hofmann; Heyo K Kroemer; Bernhard Sperker
Determination of tetrahydrothiophene formation as a probe of in vitro busulfan metabolism by human glutathione S-transferase A1-1: use of a highly sensitive gas chromatographic-mass spectrometric method.
Journal of chromatography. B, Biomedical sciences and applications 1999;730(1):25-31.
1999: Frank Bohnenstengel; Heyo K Kroemer; Bernhard Sperker
In vitro cleavage of paracetamol glucuronide by human liver and kidney beta-glucuronidase: determination of paracetamol by capillary electrophoresis.
Journal of chromatography. B, Biomedical sciences and applications 1999;721(2):295-9.
1998: Dagmar Busse; Heyo K Kroemer; Bernhard Sperker; Thomas E Mürdter
[Treatment of cancer with cytostatics: results with high dose therapy with cyclophosphamide and drug targeting with doxorubicin].
Pharmazie in unserer Zeit 1998;27(5):216-22.
1998: Thomas E Mürdter; Bernhard Sperker; Klaus Bosslet; Peter Fritz; Heyo K Kroemer
Simultaneous high-performance liquid chromatographic determination of a glucuronyl prodrug of doxorubicin, doxorubicin and its metabolites in human lung tissue.
Journal of chromatography. B, Biomedical sciences and applications 1998;709(2):289-95.
1998: Klaus Bosslet; R Straub; M Blumrich; J Czech; Manfred Gerken; Bernhard Sperker; Heyo K Kroemer; Jean-Pierre Gesson; M Koch; Claude Monneret
Elucidation of the mechanism enabling tumor selective prodrug monotherapy.
Cancer research 1998;58(6):1195-201.
1997: Bernhard Sperker; Janne T Backman; Heyo K Kroemer
The role of beta-glucuronidase in drug disposition and drug targeting in humans.
Clinical pharmacokinetics 1997;33(1):18-31.
1997: Thomas E Mürdter; Bernhard Sperker; K T Kivistö; Monika McClellan; Peter Fritz; Godehard Friedel; Albert Linder; Klaus Bosslet; Heikki Toomes; Rainer Dierkesmann; Heyo K Kroemer
Enhanced uptake of doxorubicin into bronchial carcinoma: beta-glucuronidase mediates release of doxorubicin from a glucuronide prodrug (HMR 1826) at the tumor site.
Cancer research 1997;57(12):2440-5.
1997: Bernhard Sperker; Thomas E Mürdter; M Schick; K Eckhardt; Klaus Bosslet; Heyo K Kroemer
Interindividual variability in expression and activity of human beta-glucuronidase in liver and kidney: consequences for drug metabolism.
The Journal of pharmacology and experimental therapeutics 1997;281(2):914-20.
1996: Bernhard Sperker; M Schick; Heyo K Kroemer
High-performance liquid chromatographic quantification of 4-methylumbelliferyl-beta-D-glucuronide as a probe for human beta-glucuronidase activity in tissue homogenates.
Journal of chromatography. B, Biomedical applications 1996;685(1):181-4.