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Oded Sperling

Research Profile

Anatomy

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Rats
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Ischemic Preconditioning

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Shlomo Sragovich; Yael Bromberg; Oded Sperling; Esther Zoref-Shani
Molecular alterations associated with the NMDA preconditioning-induced neuroprotective mechanism against glutamate cytotoxicity.
Hila Navon; Yael Bromberg; Oded Sperling; Esther Shani
Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation.
Oded Sperling
Hereditary renal hypouricemia.

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All Publications

2012: Shlomo Sragovich; Yael Bromberg; Oded Sperling; Esther Zoref-Shani
Molecular alterations associated with the NMDA preconditioning-induced neuroprotective mechanism against glutamate cytotoxicity.
Journal of molecular neuroscience : MN 2012;47(3):519-32.
2012: Hila Navon; Yael Bromberg; Oded Sperling; Esther Shani
Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation.
Journal of molecular neuroscience : MN 2012;46(1):100-8.
2006: Oded Sperling
Hereditary renal hypouricemia.
Molecular genetics and metabolism 2006;89(1-2):14-8.
2006: Choni Rinat; Esther Zoref-Shani; Ziva Ben-Neriah; Yael Bromberg; Rachel Becker-Cohen; Sofia Feinstein; Oded Sperling; Yaacov Frishberg
Molecular, biochemical, and genetic characterization of a female patient with Lesch-Nyhan disease.
Molecular genetics and metabolism 2006;87(3):249-52.
2006: A Rogel; Yael Bromberg; Oded Sperling; Esther Zoref-Shani
The neuroprotective adenosine-activated signal transduction pathway involves activation of phospholipase C.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1283-6.
2005: Amotz Rogel; Yael Bromberg; Oded Sperling; Esther Zoref-Shani
Phospholipase C is involved in the adenosine-activated signal transduction pathway conferring protection against iodoacetic acid-induced injury in primary rat neuronal cultures.
Neuroscience letters 2005;373(3):218-21.
2005: Ella Kratsovnik; Yael Bromberg; Oded Sperling; Esther Zoref-Shani
Oxidative stress activates transcription factor NF-kB-mediated protective signaling in primary rat neuronal cultures.
Journal of molecular neuroscience : MN 2005;26(1):27-32.
2004: Pnina Boer; Oded Sperling
Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1-pyrophosphate availability in rat hepatocyte cultures.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1235-9.
2004: Esther Zoref-Shani; Yael Bromberg; Joel Hirsch; Sofia Feinstein; Yaacov Frishberg; Oded Sperling
Clinical and biochemical manifestations and molecular characterization of the mutation HPRT Jerusalem.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1165-8.
2003: Oded Sperling; Yael Bromberg; Harrietta Oelsner; Esther Zoref-Shani
Reactive oxygen species play an important role in iodoacetate-induced neurotoxicity in primary rat neuronal cultures and in differentiated PC12 cells.
Neuroscience letters 2003;351(3):137-40.
2003: Esther Zoref-Shani; Yael Bromberg; Joel Hirsch; Sofia Feinstein; Yaacov Frishberg; Oded Sperling
A novel point mutation (I137T) in the conserved 5-phosphoribosyl-1-pyrophosphate binding motif of hypoxanthine-guanine phosphoribosyltransferase (HPRTJerusalem) in a variant of Lesch-Nyhan syndrome.
Molecular genetics and metabolism 2003;78(2):158-61.
2003: Noam Di-Capua; Oded Sperling; Esther Zoref-Shani
Protein kinase C-epsilon is involved in the adenosine-activated signal transduction pathway conferring protection against ischemia-reperfusion injury in primary rat neuronal cultures.
Journal of neurochemistry 2003;84(2):409-12.
2001: Pnina Boer; S Brosh; L Wasserman; I Hammel; Esther Zoref-Shani; Oded Sperling
Decelerated rate of dendrite outgrowth from dopaminergic neurons in primary cultures from brains of hypoxanthine phosphoribosyltransferase-deficient knockout mice.
Neuroscience letters 2001;303(1):45-8.
2001: Esther Zoref-Shani; Pnina Boer; S Brosh; D Pelled; Yael Bromberg; Oded Sperling
Purine nucleotide metabolism in cultured neurons and astroglia from HPRT-deficient knockout mice.
The Italian journal of biochemistry 2001;50(1-2):9-13.
2000: A Reshef; Oded Sperling; Esther Zoref-Shani
The adenosine-induced mechanism for the acquisition of ischemic tolerance in primary rat neuronal cultures.
Pharmacology & therapeutics 2000;87(2-3):151-9.
2000: A Reshef; N D Capua; Oded Sperling; Esther Zoref-Shani
Ischemic tolerance conferred to cultured rat neurons by heat shock is not mediated by opening of adenosine triphosphate-sensitive potassium channels.
Neuroscience letters 2000;287(3):223-6.
2000: A Reshef; Oded Sperling; Esther Zoref-Shani
Opening of K(ATP) channels is mandatory for acquisition of ischemic tolerance by adenosine.
Neuroreport 2000;11(3):463-5.
2000: Esther Zoref-Shani; Sofia Feinstein; Yaacov Frishberg; Yael Bromberg; Oded Sperling
Kelley-Seegmiller syndrome due to a unique variant of hypoxanthine-guanine phosphoribosyltransferase: reduced affinity for 5-phosphoribosyl-1-pyrophosphate manifested only at low, physiological substrate concentrations.
Biochimica et biophysica acta 2000;1500(2):197-203.
2000: S Brosh; Pnina Boer; Oded Sperling; Esther Zoref-Shani
Elevated UTP and CTP content in cultured neurons from HPRT-deficient transgenic mice.
Journal of molecular neuroscience : MN 2000;14(1-2):87-91.
2000: A Reshef; Oded Sperling; Esther Zoref-Shani
Role of K(ATP) channels in the induction of ischemic tolerance by the 'adenosine mechanism' in neuronal cultures.
Advances in experimental medicine and biology 2000;486():217-21.
1999: D Pelled; Oded Sperling; Esther Zoref-Shani
Abnormal purine and pyrimidine nucleotide content in primary astroglia cultures from hypoxanthine-guanine phosphoribosyltransferase-deficient transgenic mice.
Journal of neurochemistry 1999;72(3):1139-45.
1998: A Reshef; Oded Sperling; Esther Zoref-Shani
Opening of ATP-sensitive potassium channels by cromakalim confers tolerance against chemical ischemia in rat neuronal cultures.
Neuroscience letters 1998;250(2):111-4.
1998: Pnina Boer; S Giler; Oded Sperling
Cyclic AMP decreases the availability of 5-phosphoribosyl-1-pyrophosphate and decelerates de novo purine synthesis in rat hepatocytes.
Life sciences 1998;62(23):2133-9.
1998: A Reshef; Oded Sperling; Esther Zoref-Shani
Adenosine-induced preconditioning of rat neuronal cultures against ischemia-reperfusion injury.
Advances in experimental medicine and biology 1998;431():365-8.
1997: A Reshef; Oded Sperling; Esther Zoref-Shani
Activation and inhibition of protein kinase C protect rat neuronal cultures against ischemia-reperfusion insult.
Neuroscience letters 1997;238(1-2):37-40.
1996: A Reshef; Oded Sperling; Esther Zoref-Shani
Preconditioning of primary rat neuronal cultures against ischemic injury: characterization of the "time window of protection'.
Brain research 1996;741(1-2):252-7.
1996: S Brosh; Esther Zoref-Shani; E Danziger; Y Bromberg; Oded Sperling; Y Sidi
Adenine nucleotide metabolism in primary rat neuronal cultures.
The international journal of biochemistry & cell biology 1996;28(3):319-28.
1995: Esther Zoref-Shani; Y Bromberg; Gila Lilling; Illana Gozes; S Brosh; Y Sidi; Oded Sperling
Developmental changes in purine nucleotide metabolism in cultured rat astroglia.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1995;13(8):887-96.
1995: P Boer; Oded Sperling
Role of cellular ribose-5-phosphate content in the regulation of 5-phosphoribosyl-1-pyrophosphate and de novo purine synthesis in a human hepatoma cell line.
Metabolism: clinical and experimental 1995;44(11):1469-74.
1995: Esther Zoref-Shani; C Shirin; Y Sidi; Y Bromberg; Oded Sperling
Metabolism of guanine and guanine nucleotides in primary rat cardiomyocyte cultures.
Biochemical and molecular medicine 1995;55(2):149-55.
1994: Y Bromberg; E Shani; G Joseph; Yara Gorzalczany; Oded Sperling; Edgar Pick
The GDP-bound form of the small G protein Rac1 p21 is a potent activator of the superoxide-forming NADPH oxidase of macrophages.
The Journal of biological chemistry 1994;269(10):7055-8.
1994: Esther Zoref-Shani; R Lavie; Y Bromberg; Einat Beery; Y Sidi; Oded Sperling; Jardena Nordenberg
Effects of differentiation-inducing agents on purine nucleotide metabolism in an ovarian cancer cell line.
Journal of cancer research and clinical oncology 1994;120(12):717-22.
1994: A Halabe; Oded Sperling
Uric acid nephrolithiasis.
Mineral and electrolyte metabolism 1994;20(6):424-31.
1993: Esther Zoref-Shani; Y Bromberg; S Brosh; Y Sidi; Oded Sperling
Characterization of the alterations in purine nucleotide metabolism in hypoxanthine-guanine phosphoribosyltransferase-deficient rat neuroma cell line.
Journal of neurochemistry 1993;61(2):457-63.
1992: S Brosh; Oded Sperling; E Dantziger; Y Sidi
Metabolism of guanine and guanine nucleotides in primary rat neuronal cultures.
Journal of neurochemistry 1992;58(4):1485-90.
1992: Esther Zoref-Shani; Y Bromberg; C Shirin; Y Sidi; Oded Sperling
Metabolic fate of hypoxanthine and inosine in cultured cardiomyocytes.
Journal of molecular and cellular cardiology 1992;24(2):183-9.
1991: P Boer; R Mamet; Oded Sperling
Acceleration of purine synthesis in mouse liver by glycogenolytic hormones.
Biochemical medicine and metabolic biology 1991;46(2):185-95.
1991: P Boer; Oded Sperling
Stimulation of ribose-5-phosphate and 5-phosphoribosyl-1-pyrophosphate generation by pyrroline-5-carboxylate in mouse liver in vivo: evidence for a regulatory role of ribose-5-phosphate availability in nucleotide synthesis.
Biochemical medicine and metabolic biology 1991;46(1):28-32.
1991: Esther Zoref-Shani; Y Bromberg; C Shirin; Y Sidi; Oded Sperling
Hypoxanthine and inosine metabolism in cultured rat cardiomyocytes.
Advances in experimental medicine and biology 1991;309A():321-5.
1991: S Brosh; Oded Sperling; E Dantziger; Y Sidi
Guanine metabolism in primary rat neuronal cells.
Advances in experimental medicine and biology 1991;309B():257-60.
1991: P Boer; Oded Sperling
The effect of pyrroline-5-carboxylate on R5P and PRPP generation in mouse liver in vivo.
Advances in experimental medicine and biology 1991;309B():379-81.
1990: S Brosh; Oded Sperling; Y Bromberg; Y Sidi
Developmental changes in the activity of enzymes of purine metabolism in rat neuronal cells in culture and in whole brain.
Journal of neurochemistry 1990;54(5):1776-81.
1989: Esther Zoref-Shani; Y Bromberg; Boleslaw Goldman; R Shaki; Gad Barkai; Cyril Legum; Oded Sperling
Prenatal diagnosis of Lesch-Nyhan syndrome: experience with three fetuses at risk.
Prenatal diagnosis 1989;9(9):657-61.
1989: Y Sidi; I Gelvan; S Brosh; J Pinkhas; Oded Sperling
Guanine ribonucleotide metabolism in human red blood cells: evidence for a high rate of GMP dephosphorylation.
Biochemical medicine and metabolic biology 1989;41(2):149-54.
1989: S Brosh; Oded Sperling; Y Bromberg; Y Sidi
Enzymes of purine nucleotide metabolism in mature cultures of rat brain neurons.
Advances in experimental medicine and biology 1989;253B():489-92.
1989: Esther Zoref-Shani; Gania Kessler-Icekson; Oded Sperling
AMP catabolism in primary rat cardiomyocyte cultures.
Advances in experimental medicine and biology 1989;253A():359-62.
1989: Y Sidi; I Gelvan; S Brosh; J Pinkhas; Oded Sperling
Guanine nucleotide metabolism in red blood cells: the metabolic basis for GTP depletion in HGPRT and PNP deficiency.
Advances in experimental medicine and biology 1989;253A():67-71.
1988: Esther Zoref-Shani; Gania Kessler-Icekson; Oded Sperling
Pathways of adenine nucleotide catabolism in primary rat cardiomyocyte cultures.
Journal of molecular and cellular cardiology 1988;20(1):23-33.
1987: Esther Zoref-Shani; A Shainberg; Oded Sperling
Pathways of adenine nucleotide catabolism in primary rat muscle cultures.
Biochimica et biophysica acta 1987;926(3):287-95.
1986: Esther Zoref-Shani; A Shainberg; Gania Kessler-Icekson; Oded Sperling
Production and degradation of AMP in cultured rat skeletal and heart muscle: a comparative study.
Advances in experimental medicine and biology 1986;195 Pt B():485-91.
1986: P Boer; S Brosh; Oded Sperling
Hormone-induced stimulation of phosphoribosylpyrophosphate and of purine synthesis in mouse liver in vivo.
Advances in experimental medicine and biology 1986;195 Pt B():633-7.
1984: Esther Zoref-Shani; Gania Kessler-Icekson; L Wasserman; Oded Sperling
Characterization of purine nucleotide metabolism in primary rat cardiomyocyte cultures.
Biochimica et biophysica acta 1984;804(2):161-8.
1984: Esther Zoref-Shani; A Shainberg; Oded Sperling
Purine nucleotide metabolism in primary rat skeletal muscle cultures.
Advances in experimental medicine and biology 1984;165 Pt B():425-9.
1984: B Shohat; G Agam; S Brosh; Oded Sperling; N Sharon
Adenosine deaminase activity in lymphocyte subpopulations of B-16 melanoma and normal C57BL bearing mice.
Immunology letters 1984;8(6):307-10.
1984: S Brosh; P Boer; Oded Sperling
Effects of fructose on purine nucleotide metabolism in isolated rat hepatocytes.
Advances in experimental medicine and biology 1984;165 Pt A():481-5.
1984: A Fattal; Z Spirer; Esther Zoref-Shani; Oded Sperling
Lesch-Nyhan syndrome: biochemical characterization of a case with attenuated behavioral manifestation.
Enzyme 1984;31(1):55-60.
1984: Y Sidi; P Livne; S Brosh; M Pecht; D Shilder; J Pinkhas; N Trainin; Oded Sperling
The activities of enzymes of purine metabolism in murine thymus dependent lymphocytes.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1984;38(9-10):455-8.
1983: Esther Zoref-Shani; A Shainberg; Oded Sperling
Alterations in purine nucleotide metabolism during muscle differentiation in vitro.
Biochemical and biophysical research communications 1983;116(2):507-12.
1982: U A Liberman; R Samuel; A Halabe; H Joshua; E Lubin; Esther Zoref-Shani; Oded Sperling
Juvenile metabolic gout caused by chronic compensated hemolytic syndrome.
Arthritis and rheumatism 1982;25(10):1264-6.
1982: S Brosh; P Boer; Oded Sperling
Effects of fructose on synthesis and degradation of purine nucleotides in isolated rat hepatocytes.
Biochimica et biophysica acta 1982;717(3):459-64.
1982: Esther Zoref-Shani; A Shainberg; Oded Sperling
Characterization of purine nucleotide metabolism in primary rat muscle cultures.
Biochimica et biophysica acta 1982;716(3):324-30.
1982: S Brosh; P Boer; Esther Zoref-Shani; Oded Sperling
De novo purine synthesis in skeletal muscle.
Biochimica et biophysica acta 1982;714(1):181-3.
1981: A Shaltiel; E Katzuni; P Boer; Esther Zoref-Shani; Oded Sperling
Lesch-Nyhan syndrome in an Arab family. Detection and biochemical manifestation of heterozygosity.
Israel journal of medical sciences 1981;17(12):1169-73.
1981: S Brosh; P Boer; Oded Sperling
Glycogenolysis-induced acceleration of "de novo" purine synthesis in mouse liver.
Biomedicine / [publiée pour l'A.A.I.C.I.G.] 1981;35(2):50-1.
1981: H Bessler; S Brosh; Oded Sperling; M Djaldetti; C Moroz
The metabolism of adenosine and distribution of adenosine receptor lymphocytes in two human circulating T cell subsets.
Journal of immunopharmacology 1981;3(3-4):265-75.
1980: Esther Zoref-Shani; Oded Sperling
Dependence of the metabolic fate of IMP on the rate of total IMP synthesis. Studies in cultured fibroblasts from normal subjects and from purine-overproducing mutant patients.
Biochimica et biophysica acta 1980;607(3):503-11.
1980: Esther Zoref-Shani; Oded Sperling
Characterization of purine nucleotide metabolism in cultured fibroblasts with deficiency of hypoxanthine-guanine phosphoribosyltransferase and with superactivity of phosphoribosylpyrophosphate synthetase.
Enzyme 1980;25(6):413-8.