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Sarah Spiegel

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
89
Milstien, Sheldon
33
Olivera, Ana
22
Edsall, Lisa
21
Maceyka, Michael
20
Payne, Shawn
14
Cuvillier, Olivier
12
Le Stunff, Hervé
11
Nava, Victor
11
Van Brocklyn, James
11
Hobson, John
10
Paugh, Steven
10
Dent, Paul
10
Bektas, Meryem
9
Grant, Steven
9
Hait, Nitai

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Publications

TOP 3
Voelkel Norbert F; Spiegel Sarah
Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma.
Price Megan M; Kapitonov Dmitri; Allegood Jeremy; Milstien Sheldon; Oskeritzian Carole A; Spiegel Sarah
Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors.
Hait Nitai C; Allegood Jeremy; Maceyka Michael; Strub Graham M; Harikumar Kuzhuvelil B; Singh Sandeep K; Luo Cheng; Marmorstein Ronen; Kordula Tomasz; Milstien Sheldon; Spiegel Sarah
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

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All Publications

2009: Voelkel Norbert F; Spiegel Sarah
Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma.
Immunology and cell biology 2009;87(8):601-5.
2009: Price Megan M; Kapitonov Dmitri; Allegood Jeremy; Milstien Sheldon; Oskeritzian Carole A; Spiegel Sarah
Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(10):3506-15.
2009: Hait Nitai C; Allegood Jeremy; Maceyka Michael; Strub Graham M; Harikumar Kuzhuvelil B; Singh Sandeep K; Luo Cheng; Marmorstein Ronen; Kordula Tomasz; Milstien Sheldon; Spiegel Sarah
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
Science (New York, N.Y.) 2009;325(5945):1254-7.
2009: Kapitonov Dmitri; Allegood Jeremy C; Mitchell Clint; Hait Nitai C; Almenara Jorge A; Adams Jeffrey K; Zipkin Robert E; Dent Paul; Kordula Tomasz; Milstien Sheldon; Spiegel Sarah
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.
Cancer research 2009;69(17):6915-23.
2009: Sim-Selley Laura J; Goforth Paulette B; Mba Mba U; Macdonald Timothy L; Lynch Kevin R; Milstien Sheldon; Spiegel Sarah; Satin Leslie S; Welch Sandra P; Selley Dana E
Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS.
Journal of neurochemistry 2009;110(4):1191-202.
2009: Kim Roger H; Takabe Kazuaki; Milstien Sheldon; Spiegel Sarah
Export and functions of sphingosine-1-phosphate.
Biochimica et biophysica acta 2009;1791(7):692-6.
2009: Maceyka Michael; Milstien Sheldon; Spiegel Sarah
Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling.
Journal of lipid research 2009;50 Suppl():S272-6.
2009: Paugh Barbara S; Bryan Lauren; Paugh Steven W; Wilczynska Katarzyna M; Alvarez Silvina M; Singh Sandeep K; Kapitonov Dmitri; Rokita Hanna; Wright Sarah; Griswold-Prenner Irene; Milstien Sheldon; Spiegel Sarah; Kordula Tomasz
Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells.
The Journal of biological chemistry 2009;284(6):3408-17.
2008: Park Margaret A; Zhang Guo; Martin Aditi Pandya; Hamed Hossein; Mitchell Clint; Hylemon Philip B; Graf Martin; Rahmani Mohamed; Ryan Kevin; Liu Xiang; Spiegel Sarah; Norris James; Fisher Paul B; Grant Steven; Dent Paul
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.
Cancer biology & therapy 2008;7(10):1648-62.
2008: Bryan Lauren; Paugh Barbara S; Kapitonov Dmitri; Wilczynska Katarzyna M; Alvarez Silvina M; Singh Sandeep K; Milstien Sheldon; Spiegel Sarah; Kordula Tomasz
Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness.
Molecular cancer research : MCR 2008;6(9):1469-77.
2008: Maceyka Michael; Alvarez Sergio E; Milstien Sheldon; Spiegel Sarah
Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration.
Molecular and cellular biology 2008;28(18):5687-97.
2008: Bryan Lauren; Kordula Tomasz; Spiegel Sarah; Milstien Sheldon
Regulation and functions of sphingosine kinases in the brain.
Biochimica et biophysica acta 2008;1781(9):459-66.
2008: Shida Dai; Fang Xianjun; Kordula Tomasz; Takabe Kazuaki; Lépine Sandrine; Alvarez Sergio E; Milstien Sheldon; Spiegel Sarah
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Cancer research 2008;68(16):6569-77.
2008: Shida Dai; Takabe Kazuaki; Kapitonov Dmitri; Milstien Sheldon; Spiegel Sarah
Targeting SphK1 as a new strategy against cancer.
Current drug targets 2008;9(8):662-73.
2008: Paugh Steven W; Paugh Barbara S; Rahmani Mohamed; Kapitonov Dmitri; Almenara Jorge A; Kordula Tomasz; Milstien Sheldon; Adams Jeffrey K; Zipkin Robert E; Grant Steven; Spiegel Sarah
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
Blood 2008;112(4):1382-91.
2008: Gude David R; Alvarez Sergio E; Paugh Steven W; Mitra Poulami; Yu JiaDe; Griffiths Rachael; Barbour Suzanne E; Milstien Sheldon; Spiegel Sarah
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(8):2629-38.
2008: Lebman Deborah A; Spiegel Sarah
Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling.
Journal of lipid research 2008;49(7):1388-94.
2008: Takabe Kazuaki; Paugh Steven W; Milstien Sheldon; Spiegel Sarah
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.
Pharmacological reviews 2008;60(2):181-95.
2008: Miller Anna V; Alvarez Sergio E; Spiegel Sarah; Lebman Deborah A
Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells.
Molecular and cellular biology 2008;28(12):4142-51.
2008: Park Margaret A; Yacoub Adly; Sarkar Devanand; Emdad Luni; Rahmani Mohammed; Spiegel Sarah; Koumenis Costas; Graf Martin; Curiel David T; Grant Steven; Fisher Paul B; Dent Paul
PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells.
Autophagy 2008;4(4):513-5.
2008: Park Margaret A; Yacoub Adly; Rahmani Mohammed; Zhang Guo; Hart Lori; Hagan Michael P; Calderwood Stuart K; Sherman Michael Y; Koumenis Costas; Spiegel Sarah; Chen Ching-Shih; Graf Martin; Curiel David T; Fisher Paul B; Grant Steven; Dent Paul
OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells.
Molecular pharmacology 2008;73(4):1168-84.
2008: Oskeritzian Carole A; Alvarez Sergio E; Hait Nitai C; Price Megan M; Milstien Sheldon; Spiegel Sarah
Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions.
Blood 2008;111(8):4193-200.
2008: Ryan John J; Spiegel Sarah
The role of sphingosine-1-phosphate and its receptors in asthma.
Drug news & perspectives 2008;21(2):89-96.
2008: Yacoub Adly; Park Margaret A; Gupta Pankaj; Rahmani Mohammed; Zhang Guo; Hamed Hossein; Hanna David; Sarkar Devanand; Lebedeva Irina V; Emdad Luni; Sauane Moira; Vozhilla Nicollaq; Spiegel Sarah; Koumenis Costas; Graf Martin; Curiel David T; Grant Steven; Fisher Paul B; Dent Paul
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.
Molecular cancer therapeutics 2008;7(2):297-313.
2008: Paugh Barbara S; Paugh Steven W; Bryan Lauren; Kapitonov Dmitri; Wilczynska Katarzyna M; Gopalan Sunita M; Rokita Hanna; Milstien Sheldon; Spiegel Sarah; Kordula Tomasz
EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(2):455-65.
2007: Sankala Heidi M; Hait Nitai C; Paugh Steven W; Shida Dai; Lépine Sandrine; Elmore Lynne W; Dent Paul; Milstien Sheldon; Spiegel Sarah
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin.
Cancer research 2007;67(21):10466-74.
2007: Le Stunff Hervé; Giussani Paola; Maceyka Michael; Lépine Sandrine; Milstien Sheldon; Spiegel Sarah
Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2.
The Journal of biological chemistry 2007;282(47):34372-80.
2007: Coelho Rochelle P; Payne Shawn G; Bittman Robert; Spiegel Sarah; Sato-Bigbee Carmen
The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.
The Journal of pharmacology and experimental therapeutics 2007;323(2):626-35.
2007: Alvarez Sergio E; Milstien Sheldon; Spiegel Sarah
Autocrine and paracrine roles of sphingosine-1-phosphate.
Trends in endocrinology and metabolism: TEM 2007;18(8):300-7.
2007: Watterson Kenneth R; Lanning David A; Diegelmann Robert F; Spiegel Sarah
Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2007;15(5):607-16.
2007: Oskeritzian Carole A; Milstien Sheldon; Spiegel Sarah
Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis.
Pharmacology & therapeutics 2007;115(3):390-9.
2007: Watterson Kenneth R; Berg Krystina M; Kapitonov Dmitri; Payne Shawn G; Miner Amy S; Bittman Robert; Milstien Sheldon; Ratz Paul H; Spiegel Sarah
Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2818-28.
2007: Milstien Sheldon; Gude David; Spiegel Sarah
Sphingosine 1-phosphate in neural signalling and function.
Acta paediatrica (Oslo, Norway : 1992). Supplement 2007;96(455):40-3.
2007: Hait Nitai C; Bellamy Andrea; Milstien Sheldon; Kordula Tomasz; Spiegel Sarah
Sphingosine kinase type 2 activation by ERK-mediated phosphorylation.
The Journal of biological chemistry 2007;282(16):12058-65.
2007: Mitra Poulami; Maceyka Michael; Payne Shawn G; Lamour Nadia; Milstien Sheldon; Chalfant Charles E; Spiegel Sarah
Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells.
FEBS letters 2007;581(4):735-40.
2007: Payne Shawn G; Oskeritzian Carole A; Griffiths Rachael; Subramanian Preeti; Barbour Suzanne E; Chalfant Charles E; Milstien Sheldon; Spiegel Sarah
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
Blood 2007;109(3):1077-85.
2007: Maceyka Michael; Milstien Sheldon; Spiegel Sarah
Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate.
Circulation research 2007;100(1):7-9.
2007: Spiegel Sarah; Milstien Sheldon
Functions of the multifaceted family of sphingosine kinases and some close relatives.
The Journal of biological chemistry 2007;282(4):2125-9.
2007: Mitra Poulami; Payne Shawn G; Milstien Sheldon; Spiegel Sarah
A rapid and sensitive method to measure secretion of sphingosine-1-phosphate.
Methods in enzymology 2007;434():257-64.
2007: Maceyka Michael; Milstien Sheldon; Spiegel Sarah
Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo.
Methods in enzymology 2007;434():243-56.
2006: Hait Nitai C; Oskeritzian Carole A; Paugh Steven W; Milstien Sheldon; Spiegel Sarah
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.
Biochimica et biophysica acta 2006;1758(12):2016-26.
2006: Mitra Poulami; Oskeritzian Carole A; Payne Shawn G; Beaven Michael A; Milstien Sheldon; Spiegel Sarah
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16394-9.
2006: Movafagh Sharareh; Hobson John P; Spiegel Sarah; Kleinman Hynda K; Zukowska Zofia
Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(11):1924-6.
2006: Giussani Paola; Maceyka Michael; Le Stunff Hervé; Mikami Aki; Lépine Sandrine; Wang Elaine; Kelly Samuel; Merrill Alfred H; Milstien Sheldon; Spiegel Sarah
Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.
Molecular and cellular biology 2006;26(13):5055-69.
2006: Paugh Steven W; Cassidy Michael P; He Hengjun; Milstien Sheldon; Sim-Selley Laura J; Spiegel Sarah; Selley Dana E
Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.
Molecular pharmacology 2006;70(1):41-50.
2006: Milstien Sheldon; Spiegel Sarah
Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics.
Cancer cell 2006;9(3):148-50.
2006: Rosato Roberto R; Maggio Sonia C; Almenara Jorge A; Payne Shawn G; Atadja Peter; Spiegel Sarah; Dent Paul; Grant Steven
The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide.
Molecular pharmacology 2006;69(1):216-25.
2005: Dent Paul; Fang Youwen; Gupta Seema; Studer Elaine; Mitchell Clint; Spiegel Sarah; Hylemon Philip B
Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.
Hepatology (Baltimore, Md.) 2005;42(6):1291-9.
2005: Mizugishi Kiyomi; Yamashita Tadashi; Olivera Ana; Miller Georgina F; Spiegel Sarah; Proia Richard L
Essential role for sphingosine kinases in neural and vascular development.
Molecular and cellular biology 2005;25(24):11113-21.
2005: Saini Harsimran S; Coelho Rochelle P; Goparaju Sravan K; Jolly Puneet S; Maceyka Michael; Spiegel Sarah; Sato-Bigbee Carmen
Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors.
Journal of neurochemistry 2005;95(5):1298-310.
2005: Spiegel S; Milstien S
Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells.
Biochemical Society transactions 2005;33(Pt 6):1362-5.
2005: Maceyka Michael; Sankala Heidi; Hait Nitai C; Le Stunff Hervé; Liu Hong; Toman Rachelle; Collier Claiborne; Zhang Min; Satin Leslie S; Merrill Alfred H; Milstien Sheldon; Spiegel Sarah
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.
The Journal of biological chemistry 2005;280(44):37118-29.
2005: Chalfant Charles E; Spiegel Sarah
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling.
Journal of cell science 2005;118(Pt 20):4605-12.
2005: Sarkar Sukumar; Maceyka Michael; Hait Nitai C; Paugh Steven W; Sankala Heidi; Milstien Sheldon; Spiegel Sarah
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.
FEBS letters 2005;579(24):5313-7.
2005: Maceyka Michael; Milstien Sheldon; Spiegel Sarah
Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics.
Prostaglandins & other lipid mediators 2005;77(1-4):15-22.
2005: Hait Nitai C; Sarkar Sukumar; Le Stunff Hervé; Mikami Aki; Maceyka Michael; Milstien Sheldon; Spiegel Sarah
Role of sphingosine kinase 2 in cell migration toward epidermal growth factor.
The Journal of biological chemistry 2005;280(33):29462-9.
2005: Hinkovska-Galcheva Vania; Boxer Laurence A; Kindzelskii Andrei; Hiraoka Miki; Abe Akira; Goparju Sravan; Spiegel Sarah; Petty Howard R; Shayman James A
Ceramide 1-phosphate, a mediator of phagocytosis.
The Journal of biological chemistry 2005;280(28):26612-21.
2005: Bektas Meryem; Payne Shawn G; Liu Hong; Goparaju Sravan; Milstien Sheldon; Spiegel Sarah
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells.
The Journal of cell biology 2005;169(5):801-11.
2005: Jolly Puneet S; Bektas Meryem; Watterson Kenneth R; Sankala Heidi; Payne Shawn G; Milstien Sheldon; Spiegel Sarah
Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.
Blood 2005;105(12):4736-42.
2005: Safadi-Chamberlain Farida; Wang Li-Ping; Payne Shawn G; Lim Chang-Uk; Stratford Suzanne; Chavez Jose Antonio; Fox Michael H; Spiegel Sarah; Summers Scott A
Effect of a membrane-targeted sphingosine kinase 1 on cell proliferation and survival.
The Biochemical journal 2005;388(Pt 3):827-34.
2005: Goparaju Sravan K; Jolly Puneet S; Watterson Kenneth R; Bektas Meryem; Alvarez Sergio; Sarkar Sukumar; Mel Lin; Ishii Isao; Chun Jerold; Milstien Sheldon; Spiegel Sarah
The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation.
Molecular and cellular biology 2005;25(10):4237-49.
2005: Schulzke J D; Gitter A H; Mankertz J; Spiegel S; Seidler U; Amasheh S; Saitou M; Tsukita S; Fromm M
Epithelial transport and barrier function in occludin-deficient mice.
Biochimica et biophysica acta 2005;1669(1):34-42.
2005: Rahmani Mohamed; Reese Erin; Dai Yun; Bauer Cheryl; Payne Shawn G; Dent Paul; Spiegel Sarah; Grant Steven
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.
Cancer research 2005;65(6):2422-32.
2005: Watterson Kenneth R; Ratz Paul H; Spiegel Sarah
The role of sphingosine-1-phosphate in smooth muscle contraction.
Cellular signalling 2005;17(3):289-98.
2005: Coursol Sylvie; Le Stunff Hervé; Lynch Daniel V; Gilroy Simon; Assmann Sarah M; Spiegel Sarah
Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture.
Plant physiology 2005;137(2):724-37.
2005: Bektas Meryem; Jolly Puneet S; Müller Carola; Eberle Jürgen; Spiegel Sarah; Geilen Christoph C
Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression.
Oncogene 2005;24(1):178-87.
2004: Allende Maria L; Sasaki Teiji; Kawai Hiromichi; Olivera Ana; Mi Yide; van Echten-Deckert Gerhild; Hajdu Richard; Rosenbach Mark; Keohane Carol Ann; Mandala Suzanne; Spiegel Sarah; Proia Richard L
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.
The Journal of biological chemistry 2004;279(50):52487-92.
2004: Payne Shawn G; Milstien Sheldon; Barbour Suzanne E; Spiegel Sarah
Modulation of adaptive immune responses by sphingosine-1-phosphate.
Seminars in cell & developmental biology 2004;15(5):521-7.
2004: Toman Rachelle E; Payne Shawn G; Watterson Kenneth R; Maceyka Michael; Lee Norman H; Milstien Sheldon; Bigbee John W; Spiegel Sarah
Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension.
The Journal of cell biology 2004;166(3):381-92.
2004: Le Stunff Hervé; Milstien Sheldon; Spiegel Sarah
Generation and metabolism of bioactive sphingosine-1-phosphate.
Journal of cellular biochemistry 2004;92(5):882-99.
2004: Le Stunff Hervé; Mikami Aki; Giussani Paola; Hobson John P; Jolly Puneet S; Milstien Sheldon; Spiegel Sarah
Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis.
The Journal of biological chemistry 2004;279(33):34290-7.
2004: Maceyka Michael; Nava Victor E; Milstien Sheldon; Spiegel Sarah
Aminoacylase 1 is a sphingosine kinase 1-interacting protein.
FEBS letters 2004;568(1-3):30-4.
2004: Jolly Puneet S; Bektas Meryem; Olivera Ana; Gonzalez-Espinosa Claudia; Proia Richard L; Rivera Juan; Milstien Sheldon; Spiegel Sarah
Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis.
The Journal of experimental medicine 2004;199(7):959-70.
2004: Maggio Sonia C; Rosato Roberto R; Kramer Lora B; Dai Yun; Rahmani Mohamed; Paik David S; Czarnik Ann C; Payne Shawn G; Spiegel Sarah; Grant Steven
The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.
Cancer research 2004;64(7):2590-600.
2004: Gupta Seema; Natarajan Ramesh; Payne Shawn G; Studer Elaine J; Spiegel Sarah; Dent Paul; Hylemon Phillip B
Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation.
The Journal of biological chemistry 2004;279(7):5821-8.
2004: Bektas Meryem; Spiegel Sarah
Glycosphingolipids and cell death.
Glycoconjugate journal 2004;20(1):39-47.
2003: Spiegel S; Milstien S
Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways.
Biochemical Society transactions 2003;31(Pt 6):1216-9.
2003: Paugh Steven W; Payne Shawn G; Barbour Suzanne E; Milstien Sheldon; Spiegel Sarah
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.
FEBS letters 2003;554(1-2):189-93.
2003: Olivera Ana; Rosenfeldt Hans M; Bektas Meryem; Wang Fang; Ishii Isao; Chun Jerold; Milstien Sheldon; Spiegel Sarah
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors.
The Journal of biological chemistry 2003;278(47):46452-60.
2003: Bektas Meryem; Barak Larry S; Jolly Puneet S; Liu Hong; Lynch Kevin R; Lacana Emanuela; Suhr Ki-Beom; Milstien Sheldon; Spiegel Sarah
The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.
Biochemistry 2003;42(42):12181-91.
2003: Rosenfeldt Hans M; Amrani Yassine; Watterson Kenneth R; Murthy Karnam S; Panettieri Reynold A; Spiegel Sarah
Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1789-99.
2003: Escalante-Alcalde Diana; Hernandez Lidia; Le Stunff Hervé; Maeda Ryu; Lee Hyun-Shik; Jr-Gang-Cheng; Sciorra Vicki A; Daar Ira; Spiegel Sarah; Morris Andrew J; Stewart Colin L
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning.
Development (Cambridge, England) 2003;130(19):4623-37.
2003: Pettus Benjamin J; Bielawska Alicja; Spiegel Sarah; Roddy Patrick; Hannun Yusuf A; Chalfant Charles E
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.
The Journal of biological chemistry 2003;278(40):38206-13.
2003: Liu Hong; Toman Rachelle E; Goparaju Sravan K; Maceyka Michael; Nava Victor E; Sankala Heidi; Payne Shawn G; Bektas Meryem; Ishii Isao; Chun Jerold; Milstien Sheldon; Spiegel Sarah
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis.
The Journal of biological chemistry 2003;278(41):40330-6.
2003: Bektas Meryem; Jolly Puneet S; Milstien Sheldon; Spiegel Sarah
A specific ceramide kinase assay to measure cellular levels of ceramide.
Analytical biochemistry 2003;320(2):259-65.
2003: Watterson Kenneth; Sankala Heidi; Milstien Sheldon; Spiegel Sarah
Pleiotropic actions of sphingosine-1-phosphate.
Progress in lipid research 2003;42(4):344-57.
2003: Coursol Sylvie; Fan Liu-Min; Le Stunff Hervé; Spiegel Sarah; Gilroy Simon; Assmann Sarah M
Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins.
Nature 2003;423(6940):651-4.
2003: Gonzalez-Espinosa Claudia; Odom Sandra; Olivera Ana; Hobson J Peyton; Martinez Maria Eugenia Cid; Oliveira-Dos-Santos Antonio; Barra Lillian; Spiegel Sarah; Penninger Josef M; Rivera Juan
Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells.
The Journal of experimental medicine 2003;197(11):1453-65.
2003: Spiegel Sarah; Milstien Sheldon
Sphingosine-1-phosphate: an enigmatic signalling lipid.
Nature reviews. Molecular cell biology 2003;4(5):397-407.
2003: Kimura K; Markowski M; Edsall L C; Spiegel S; Gelmann E P
Role of ceramide in mediating apoptosis of irradiated LNCaP prostate cancer cells.
Cell death and differentiation 2003;10(2):240-8.
2002: Maceyka Michael; Payne Shawn G; Milstien Sheldon; Spiegel Sarah
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.
Biochimica et biophysica acta 2002;1585(2-3):193-201.
2002: Nava Victor E; Hobson John Peyton; Murthy Shvetha; Milstien Sheldon; Spiegel Sarah
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells.
Experimental cell research 2002;281(1):115-27.
2002: Payne Shawn G; Milstien Sheldon; Spiegel Sarah
Sphingosine-1-phosphate: dual messenger functions.
FEBS letters 2002;531(1):54-7.
2002: Le Stunff Hervé; Galve-Roperh Ismael; Peterson Courtney; Milstien Sheldon; Spiegel Sarah
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis.
The Journal of cell biology 2002;158(6):1039-49.
2002: Jolly Puneet S; Rosenfeldt Hans M; Milstien Sheldon; Spiegel Sarah
The roles of sphingosine-1-phosphate in asthma.
Molecular immunology 2002;38(16-18):1239-45.
2002: Spiegel S; Kolesnick R
Sphingosine 1-phosphate as a therapeutic agent.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(9):1596-602.
2002: Lacaná Emanuela; Maceyka Michael; Milstien Sheldon; Spiegel Sarah
Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity.
The Journal of biological chemistry 2002;277(36):32947-53.
2002: Toman Rachelle E; Spiegel Sarah
Lysophospholipid receptors in the nervous system.
Neurochemical research 2002;27(7-8):619-27.
2002: Spiegel Sarah; Milstien Sheldon
Sphingosine 1-phosphate, a key cell signaling molecule.
The Journal of biological chemistry 2002;277(29):25851-4.
2002: Toman Rachelle E; Movsesyan Vilen; Murthy Shvetha K; Milstien Sheldon; Spiegel Sarah; Faden Alan I
Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis.
Journal of neuroscience research 2002;68(3):323-30.
2002: Le Stunff Hervé; Peterson Courtney; Liu Hong; Milstien Sheldon; Spiegel Sarah
Sphingosine-1-phosphate and lipid phosphohydrolases.
Biochimica et biophysica acta 2002;1582(1-3):8-17.
2002: Spiegel Sarah; English Denis; Milstien Sheldon
Sphingosine 1-phosphate signaling: providing cells with a sense of direction.
Trends in cell biology 2002;12(5):236-42.
2002: Vann Lewis R; Payne Shawn G; Edsall Lisa C; Twitty Sharon; Spiegel Sarah; Milstien Sheldon
Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells.
The Journal of biological chemistry 2002;277(15):12649-56.
2002: Grant Steven; Spiegel Sarah
A chicken-or-egg conundrum in apoptosis: which comes first? Ceramide or PKCdelta?
The Journal of clinical investigation 2002;109(6):717-9.
2002: Benaud Christelle; Oberst Michael; Hobson John P; Spiegel Sarah; Dickson Robert B; Lin Chen-Yong
Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase.
The Journal of biological chemistry 2002;277(12):10539-46.
2002: Le Stunff Hervé; Peterson Courtney; Thornton Rosemary; Milstien Sheldon; Mandala Suzanne M; Spiegel Sarah
Characterization of murine sphingosine-1-phosphate phosphohydrolase.
The Journal of biological chemistry 2002;277(11):8920-7.
2002: Liu Hong; Chakravarty Debyani; Maceyka Michael; Milstien Sheldon; Spiegel Sarah
Sphingosine kinases: a novel family of lipid kinases.
Progress in nucleic acid research and molecular biology 2002;71():493-511.
2001: Rosenfeldt H M; Hobson J P; Maceyka M; Olivera A; Nava V E; Milstien S; Spiegel S
EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2649-59.
2001: Rosenfeldt H M; Hobson J P; Milstien S; Spiegel S
The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility.
Biochemical Society transactions 2001;29(Pt 6):836-9.
2001: Kleuser B; Maceyka M; Milstien S; Spiegel S
Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor.
FEBS letters 2001;503(1):85-90.
2001: Olivera A; Spiegel S
Sphingosine kinase: a mediator of vital cellular functions.
Prostaglandins & other lipid mediators 2001;64(1-4):123-34.
2001: Edsall L C; Cuvillier O; Twitty S; Spiegel S; Milstien S
Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells.
Journal of neurochemistry 2001;76(5):1573-84.
2001: Hobson J P; Rosenfeldt H M; Barak L S; Olivera A; Poulton S; Caron M G; Milstien S; Spiegel S
Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.
Science (New York, N.Y.) 2001;291(5509):1800-3.
2001: Toman R E; Milstien S; Spiegel S
Sphingosine-1-phosphate: an emerging therapeutic target.
Expert opinion on therapeutic targets 2001;5(1):109-23.
2001: Cuvillier O; Nava V E; Murthy S K; Edsall L C; Levade T; Milstien S; Spiegel S
Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.
Cell death and differentiation 2001;8(2):162-71.
2001: Malek R L; Toman R E; Edsall L C; Wong S; Chiu J; Letterle C A; Van Brocklyn J R; Milstien S; Spiegel S; Lee N H
Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors.
The Journal of biological chemistry 2001;276(8):5692-9.
2000: Toman R E; Spiegel S; Faden A I
Role of ceramide in neuronal cell death and differentiation.
Journal of neurotrauma 2000;17(10):891-8.
2000: Liu Y; Wada R; Yamashita T; Mi Y; Deng C X; Hobson J P; Rosenfeldt H M; Nava V E; Chae S S; Lee M J; Liu C H; Hla T; Spiegel S; Proia R L
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.
The Journal of clinical investigation 2000;106(8):951-61.
2000: Nava V E; Cuvillier O; Edsall L C; Kimura K; Milstien S; Gelmann E P; Spiegel S
Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells.
Cancer research 2000;60(16):4468-74.
2000: Mandala S M; Thornton R; Galve-Roperh I; Poulton S; Peterson C; Olivera A; Bergstrom J; Kurtz M B; Spiegel S
Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7859-64.
2000: Spiegel S; Milstien S
Sphingosine-1-phosphate: signaling inside and out.
FEBS letters 2000;476(1-2):55-7.
2000: Liu H; Sugiura M; Nava V E; Edsall L C; Kono K; Poulton S; Milstien S; Kohama T; Spiegel S
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.
The Journal of biological chemistry 2000;275(26):19513-20.
2000: Nava V E; Lacana E; Poulton S; Liu H; Sugiura M; Kono K; Milstien S; Kohama T; Spiegel S
Functional characterization of human sphingosine kinase-1.
FEBS letters 2000;473(1):81-4.
2000: Vann L R; Twitty S; Spiegel S; Milstien S
Divergence in regulation of nitric-oxide synthase and its cofactor tetrahydrobiopterin by tumor necrosis factor-alpha. Ceramide potentiates nitric oxide synthesis without affecting GTP cyclohydrolase I activity.
The Journal of biological chemistry 2000;275(18):13275-81.
2000: Cuvillier O; Edsall L; Spiegel S
Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells.
The Journal of biological chemistry 2000;275(21):15691-700.
2000: Spiegel S
Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.
Annals of the New York Academy of Sciences 2000;905():54-60.
2000: Spiegel S; Milstien S
Functions of a new family of sphingosine-1-phosphate receptors.
Biochimica et biophysica acta 2000;1484(2-3):107-16.
2000: Van Brocklyn J R; Gräler M H; Bernhardt G; Hobson J P; Lipp M; Spiegel S
Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.
Blood 2000;95(8):2624-9.
2000: Edsall L; Vann L; Milstien S; Spiegel S
Enzymatic method for measurement of sphingosine 1-phosphate.
Methods in enzymology 2000;312():9-16.
2000: Olivera A; Barlow K D; Spiegel S
Assaying sphingosine kinase activity.
Methods in enzymology 2000;311():215-23.
1999: Wang F; Van Brocklyn J R; Edsall L; Nava V E; Spiegel S
Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors.
Cancer research 1999;59(24):6185-91.
1999: Wang F; Van Brocklyn J R; Hobson J P; Movafagh S; Zukowska-Grojec Z; Milstien S; Spiegel S
Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis.
The Journal of biological chemistry 1999;274(50):35343-50.
1999: Cuvillier O; Mayhew E; Janoff A S; Spiegel S
Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling.
Blood 1999;94(10):3583-92.
1999: Olivera A; Kohama T; Edsall L; Nava V; Cuvillier O; Poulton S; Spiegel S
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.
The Journal of cell biology 1999;147(3):545-58.
1999: Olivera A; Edsall L; Poulton S; Kazlauskas A; Spiegel S
Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(12):1593-600.
1999: Burbelo P D; Snow D M; Bahou W; Spiegel S
MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9083-8.
1999: Spiegel S; Olah Z; Cuvillier O; Edsall L C; Janoff A S
Differential effects of free and liposome-associated 1-O-octadecyl-2-O-methylglycerophosphocholine on protein kinase C.
FEBS letters 1999;454(1-2):137-41.
1999: Edsall L C; Spiegel S
Enzymatic measurement of sphingosine 1-phosphate.
Analytical biochemistry 1999;272(1):80-6.
1999: Liu C H; Thangada S; Lee M J; Van Brocklyn J R; Spiegel S; Hla T
Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1.
Molecular biology of the cell 1999;10(4):1179-90.
1999: Kimura K; Bowen C; Spiegel S; Gelmann E P
Tumor necrosis factor-alpha sensitizes prostate cancer cells to gamma-irradiation-induced apoptosis.
Cancer research 1999;59(7):1606-14.
1999: Spiegel S
Sphingosine 1-phosphate: a prototype of a new class of second messengers.
Journal of leukocyte biology 1999;65(3):341-4.
1999: Wang F; Nohara K; Olivera A; Thompson E W; Spiegel S
Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate.
Experimental cell research 1999;247(1):17-28.
1999: Van Brocklyn J R; Tu Z; Edsall L C; Schmidt R R; Spiegel S
Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.
The Journal of biological chemistry 1999;274(8):4626-32.
1998: Edsall L C; Van Brocklyn J R; Cuvillier O; Kleuser B; Spiegel S
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.
Biochemistry 1998;37(37):12892-8.
1998: Kohama T; Olivera A; Edsall L; Nagiec M M; Dickson R; Spiegel S
Molecular cloning and functional characterization of murine sphingosine kinase.
The Journal of biological chemistry 1998;273(37):23722-8.
1998: Bowen C; Spiegel S; Gelmann E P
Radiation-induced apoptosis mediated by retinoblastoma protein.
Cancer research 1998;58(15):3275-81.
1998: Van Brocklyn J R; Lee M J; Menzeleev R; Olivera A; Edsall L; Cuvillier O; Thomas D M; Coopman P J; Thangada S; Liu C H; Hla T; Spiegel S
Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival.
The Journal of cell biology 1998;142(1):229-40.
1998: Spiegel S; Cuvillier O; Edsall L C; Kohama T; Menzeleev R; Olah Z; Olivera A; Pirianov G; Thomas D M; Tu Z; Van Brocklyn J R; Wang F
Sphingosine-1-phosphate in cell growth and cell death.
Annals of the New York Academy of Sciences 1998;845():11-8.
1998: Kleuser B; Cuvillier O; Spiegel S
1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.
Cancer research 1998;58(9):1817-24.
1998: Olivera A; Kohama T; Tu Z; Milstien S; Spiegel S
Purification and characterization of rat kidney sphingosine kinase.
The Journal of biological chemistry 1998;273(20):12576-83.
1998: Qiao L; Kozikowski A P; Olivera A; Spiegel S
Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate--caged SPP.
Bioorganic & medicinal chemistry letters 1998;8(7):711-4.
1998: Lee M J; Van Brocklyn J R; Thangada S; Liu C H; Hand A R; Menzeleev R; Spiegel S; Hla T
Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.
Science (New York, N.Y.) 1998;279(5356):1552-5.
1998: Yu M; Sato H; Seiki M; Spiegel S; Thompson E W
Elevated cyclic AMP suppresses ConA-induced MT1-MMP expression in MDA-MB-231 human breast cancer cells.
Clinical & experimental metastasis 1998;16(2):185-91.
1998: Berger A; Cultaro C M; Segal S; Spiegel S
The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix-loop-helix-zipper protein.
Biochimica et biophysica acta 1998;1390(2):225-36.
1998: Spiegel S; Cuvillier O; Edsall L; Kohama T; Menzeleev R; Olivera A; Thomas D; Tu Z; Van Brocklyn J; Wang F
Roles of sphingosine-1-phosphate in cell growth, differentiation, and death.
Biochemistry. Biokhimii?a 1998;63(1):69-73.
1998: Cuvillier O; Rosenthal D S; Smulson M E; Spiegel S
Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes.
The Journal of biological chemistry 1998;273(5):2910-6.
1998: Mandala S M; Thornton R; Tu Z; Kurtz M B; Nickels J; Broach J; Menzeleev R; Spiegel S
Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):150-5.
1998: Olivera A; Spiegel S
Sphingosine kinase. Assay and product analysis.
Methods in molecular biology (Clifton, N.J.) 1998;105():233-42.
1997: Rius R A; Edsall L C; Spiegel S
Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors.
FEBS letters 1997;417(2):173-6.
1997: Olivera A; Romanowski A; Rani C S; Spiegel S
Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts.
Biochimica et biophysica acta 1997;1348(3):311-23.
1997: Edsall L C; Pirianov G G; Spiegel S
Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):6952-60.
1997: Yu M; Sato H; Seiki M; Spiegel S; Thompson E W
Calcium influx inhibits MT1-MMP processing and blocks MMP-2 activation.
FEBS letters 1997;412(3):568-72.
1997: Blakesley V A; Beitner-Johnson D; Van Brocklyn J R; Rani S; Shen-Orr Z; Stannard B S; Spiegel S; LeRoith D
Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk.
The Journal of biological chemistry 1997;272(26):16211-5.
1997: Wang F; Nobes C D; Hall A; Spiegel S
Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts.
The Biochemical journal 1997;324 ( Pt 2)():481-8.
1997: Rani C S; Wang F; Fuior E; Berger A; Wu J; Sturgill T W; Beitner-Johnson D; LeRoith D; Varticovski L; Spiegel S
Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling.
The Journal of biological chemistry 1997;272(16):10777-83.
1996: Wang F; Buckley N E; Olivera A; Goodemote K A; Su Y; Spiegel S
Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1.
Glycoconjugate journal 1996;13(6):937-45.
1996: Spiegel S; Merrill A H
Sphingolipid metabolism and cell growth regulation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(12):1388-97.
1996: Berger A; Bittman R; Schmidt R R; Spiegel S
Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity.
Molecular pharmacology 1996;50(3):451-7.
1996: Cuvillier O; Pirianov G; Kleuser B; Vanek P G; Coso O A; Gutkind S; Spiegel S
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate.
Nature 1996;381(6585):800-3.
1996: Spiegel S; Milstien S
Sphingoid bases and phospholipase D activation.
Chemistry and physics of lipids 1996;80(1-2):27-36.
1996: Spiegel S; Foster D; Kolesnick R
Signal transduction through lipid second messengers.
Current opinion in cell biology 1996;8(2):159-67.
1996: Olivera A; Rosenthal J; Spiegel S
Effect of acidic phospholipids on sphingosine kinase.
Journal of cellular biochemistry 1996;60(4):529-37.
1995: Spiegel S; Milstien S
Sphingolipid metabolites: members of a new class of lipid second messengers.
The Journal of membrane biology 1995;146(3):225-37.
1995: Buckley N E; Su Y; Milstien S; Spiegel S
The role of calcium influx in cellular proliferation induced by interaction of endogenous ganglioside GM1 with the B subunit of cholera toxin.
Biochimica et biophysica acta 1995;1256(3):275-83.
1995: Berger A; Rosenthal D; Spiegel S
Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):5885-9.
1995: Goodemote K A; Mattie M E; Berger A; Spiegel S
Involvement of a pertussis toxin-sensitive G protein in the mitogenic signaling pathways of sphingosine 1-phosphate.
The Journal of biological chemistry 1995;270(17):10272-7.
1994: Olivera A; Rosenthal J; Spiegel S
Sphingosine kinase from Swiss 3T3 fibroblasts: a convenient assay for the measurement of intracellular levels of free sphingoid bases.
Analytical biochemistry 1994;223(2):306-12.
1994: Olivera A; Zhang H; Carlson R O; Mattie M E; Schmidt R R; Spiegel S
Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation.
The Journal of biological chemistry 1994;269(27):17924-30.
1994: Su Y; Rosenthal D; Smulson M; Spiegel S
Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.
The Journal of biological chemistry 1994;269(23):16512-7.
1994: Carlson R O; Masco D; Brooker G; Spiegel S
Endogenous ganglioside GM1 modulates L-type calcium channel activity in N18 neuroblastoma cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(4):2272-81.
1994: Mattie M; Brooker G; Spiegel S
Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.
The Journal of biological chemistry 1994;269(5):3181-8.
1994: Spiegel S; Olivera A; Zhang H; Thompson E W; Su Y; Berger A
Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells.
Breast cancer research and treatment 1994;31(2-3):337-48.
1993: Spiegel S
Sphingosine and sphingosine 1-phosphate in cellular proliferation: relationship with protein kinase C and phosphatidic acid.
Journal of lipid mediators 1993;8(3):169-75.
1993: Olivera A; Spiegel S
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens.
Nature 1993;365(6446):557-60.
1993: Desai N N; Carlson R O; Mattie M E; Olivera A; Buckley N E; Seki T; Brooker G; Spiegel S
Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts.
The Journal of cell biology 1993;121(6):1385-95.
1993: Spiegel S; Olivera A; Carlson R O
The role of sphingosine in cell growth regulation and transmembrane signaling.
Advances in lipid research 1993;25():105-29.
1992: Olivera A; Buckley N E; Spiegel S
Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts.
The Journal of biological chemistry 1992;267(36):26121-7.
1992: Desai N N; Zhang H; Olivera A; Mattie M E; Spiegel S
Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation.
The Journal of biological chemistry 1992;267(32):23122-8.
1992: Olivera A; Spiegel S
Ganglioside GM1 and sphingolipid breakdown products in cellular proliferation and signal transduction pathways.
Glycoconjugate journal 1992;9(3):110-7.
1991: Desai N N; Spiegel S
Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines.
Biochemical and biophysical research communications 1991;181(1):361-6.
1991: Masco D; Van de Walle M; Spiegel S
Interaction of ganglioside GM1 with the B subunit of cholera toxin modulates growth and differentiation of neuroblastoma N18 cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(8):2443-52.
1991: Zhang H; Desai N N; Olivera A; Seki T; Brooker G; Spiegel S
Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.
The Journal of cell biology 1991;114(1):155-67.
1990: Zhang H; Desai N N; Murphey J M; Spiegel S
Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells.
The Journal of biological chemistry 1990;265(34):21309-16.
1990: Buckley N E; Matyas G R; Spiegel S
The bimodal growth response of Swiss 3T3 cells to the B subunit of cholera toxin is independent of the density of its receptor, ganglioside GM1.
Experimental cell research 1990;189(1):13-21.
1990: Spiegel S
Cautionary note on the use of the B subunit of cholera toxin as a ganglioside GM1 probe: detection of cholera toxin A subunit in B subunit preparations by a sensitive adenylate cyclase assay.
Journal of cellular biochemistry 1990;42(3):143-52.
1990: Zhang H; Buckley N E; Gibson K; Spiegel S
Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.
The Journal of biological chemistry 1990;265(1):76-81.
1989: Spiegel S
Inhibition of protein kinase C-dependent cellular proliferation by interaction of endogenous ganglioside GM1 with the B subunit of cholera toxin.
The Journal of biological chemistry 1989;264(28):16512-7.
1989: Spiegel S
Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation.
The Journal of biological chemistry 1989;264(12):6766-72.

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