FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Sarah Spiegel

Research Profile

Chemicals & Drugs

Physiology

Living Beings

Mouse

Anatomy

Phenomena

Phosphorylation

Co-author Network

Publications

TOP 3
Santiago Lima; Sarah Spiegel
Sphingosine kinase: a closer look at last.
Megan M Price; John J Ryan; Jeremy C Allegood; Sergio E Alvarez; Daniel Conrad; Yves T Falanga; Kuzhuvelil B Harikumar; Sheldon Milstien; Carole A Oskeritzian; Sarah Spiegel
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.
Jie Liang; Sheldon Milstien; Masayuki Nagahashi; Megan M Price; Jeremy C Allegood; Dorit Avni; Nitai C Hait; Kuzhuvelil B Harikumar; Wei-Ching Huang; Eugene Y Kim; Tomasz Kordula; Kazuaki Takabe; Akimitsu Yamada; Sarah Spiegel
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Sarah Spiegel (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Santiago Lima; Sarah Spiegel
Sphingosine kinase: a closer look at last.
Structure (London, England : 1993) 2013;21(5):690-2.
2013: Megan M Price; John J Ryan; Jeremy C Allegood; Sergio E Alvarez; Daniel Conrad; Yves T Falanga; Kuzhuvelil B Harikumar; Sheldon Milstien; Carole A Oskeritzian; Sarah Spiegel
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.
The Journal of allergy and clinical immunology 2013;131(2):501-11.e1.
2013: Jie Liang; Sheldon Milstien; Masayuki Nagahashi; Megan M Price; Jeremy C Allegood; Dorit Avni; Nitai C Hait; Kuzhuvelil B Harikumar; Wei-Ching Huang; Eugene Y Kim; Tomasz Kordula; Kazuaki Takabe; Akimitsu Yamada; Sarah Spiegel
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.
Cancer cell 2013;23(1):107-20.
2013: Kai Liu; Hardik I Parikh; Sarah Spiegel; Wenfang Xu; Jeremy C Allegood; Steven Grant; Tai L Guo; Nitai C Hait; Glen E Kellogg; Shijun Zhang
Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent.
PloS one 2013;8(2):e56471.
2012: M Danielle Bareford; Nichola Cruickshanks; Jeremy C Allegood; Steven Grant; Hossein A Hamed; Besim Ogretmen; Margaret A Park; Andrew Poklepovic; Sarah Spiegel; Paul Dent
Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling.
Cancer biology & therapy 2012;13(9):793-803.
2012: Yves T Falanga; Fred D Finkelman; Bernice Huang; Motunrayo Kolawole; Sandra Odom; Carole A Oskeritzian; Nicholas A Pullen; Juan Rivera; Suzanne Barbour; Jason Carlyon; Natalia S Chaimowitz; Nicolas Charles; Daniel H Conrad; Kevin Dholaria; Travis Faber; Sarah Spiegel; John J Ryan
Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(9):4360-8.
2012: Masayuki Nagahashi; Subramaniam Ramachandran; Omar M Rashid; Sarah Spiegel; Jeremy C Allegood; Eugene Y Kim; Sheldon Milstien; Akimitsu Yamada; Renping Zhao; Huiping Zhou; Kazuaki Takabe
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.
Cancer research 2012;72(3):726-35.
2011: Ludovic Gomez; Qun Chen; Melanie Paillard; Megan Price; Sarah Spiegel; Geoffrey Teixeira; Edward J Lesnefsky
A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection.
Basic research in cardiology 2011;106(6):1341-53.
2011: Christina E Stevenson; Kazuaki Takabe; Sheldon Milstien; Masayuki Nagahashi; Sarah Spiegel
Targeting sphingosine-1-phosphate in hematologic malignancies.
Anti-cancer agents in medicinal chemistry 2011;11(9):794-8.
2011: Sarah Spiegel; Sheldon Milstien
The outs and the ins of sphingosine-1-phosphate in immunity.
Nature reviews. Immunology 2011;11(6):403-15.
2011: Margaret A Park; Hossein A Hamed; Clint Mitchell; Nichola Cruickshanks; Rupesh Dash; Jeremy C Allegood; Igor P Dmitriev; Gary Tye; Besim Ogretmen; Sarah Spiegel; Adly Yacoub; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.
Molecular pharmacology 2011;79(3):368-80.
2011: Graham M Strub; Melanie Paillard; Jie Liang; Ludovic Gomez; Jeremy C Allegood; Nitai C Hait; Michael Maceyka; Megan M Price; Qun Chen; David C Simpson; Tomasz Kordula; Sheldon Milstien; Edward J Lesnefsky; Sarah Spiegel
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(2):600-12.
2011: Sandrine Lépine; Jeremy C Allegood; Myung H Park; Paul Dent; Sheldon Milstien; Sarah Spiegel
Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy.
Cell death and differentiation 2011;18(2):350-61.
2010: Subramaniam Ramachandran; Dai Shida; Masayuki Nagahashi; Xianjun Fang; Sheldon Milstien; Kazuaki Takabe; Sarah Spiegel
Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.
FEBS letters 2010;584(18):4077-82.
2010: Sergio E Alvarez; Kuzhuvelil B Harikumar; Nitai C Hait; Jeremy Allegood; Graham M Strub; Eugene Y Kim; Michael Maceyka; Hualiang Jiang; Cheng Luo; Tomasz Kordula; Sheldon Milstien; Sarah Spiegel
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
Nature 2010;465(7301):1084-8.
2010: Kazuaki Takabe; Roger H Kim; Jeremy C Allegood; Poulami Mitra; Subramaniam Ramachandran; Masayuki Nagahashi; Kuzhuvelil B Harikumar; Nitai C Hait; Sheldon Milstien; Sarah Spiegel
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.
The Journal of biological chemistry 2010;285(14):10477-86.
2010: Carole A Oskeritzian; Megan M Price; Nitai C Hait; Dmitri Kapitonov; Yves T Falanga; Johanna K Morales; John J Ryan; Sheldon Milstien; Sarah Spiegel
Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema.
The Journal of experimental medicine 2010;207(3):465-74.
2010: Moira Sauane; Zao-Zhong Su; Rupesh Dash; Xiang Liu; James S Norris; Devanand Sarkar; Seok-Geun Lee; Jeremy C Allegood; Paul Dent; Sarah Spiegel; Paul B Fisher
Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis.
Journal of cellular physiology 2010;222(3):546-55.
2010: Adly Yacoub; Hossein A Hamed; Jeremy C Allegood; Clint Mitchell; Sarah Spiegel; Maciej S Lesniak; Besim Ogretmen; Rupesh Dash; Devanand Sarkar; William C Broaddus; Steven Grant; David T Curiel; Paul B Fisher; Paul Dent
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
Cancer research 2010;70(3):1120-9.
2010: Graham M Strub; Michael Maceyka; Nitai C Hait; Sheldon Milstien; Sarah Spiegel
Extracellular and intracellular actions of sphingosine-1-phosphate.
Advances in experimental medicine and biology 2010;688():141-55.
2009: Norbert F Voelkel; Sarah Spiegel
Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma.
Immunology and cell biology 2009;87(8):601-5.
2009: Megan M Price; Dmitri Kapitonov; Jeremy C Allegood; Sheldon Milstien; Carole A Oskeritzian; Sarah Spiegel
Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(10):3506-15.
2009: Nitai C Hait; Jeremy Allegood; Michael Maceyka; Graham M Strub; Kuzhuvelil B Harikumar; Sandeep K Singh; Cheng Luo; Ronen Marmorstein; Tomasz Kordula; Sheldon Milstien; Sarah Spiegel
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
Science (New York, N.Y.) 2009;325(5945):1254-7.
2009: Dmitri Kapitonov; Jeremy C Allegood; Clint Mitchell; Nitai C Hait; Jorge A Almenara; Jeffrey K Adams; Robert E Zipkin; Paul Dent; Tomasz Kordula; Sheldon Milstien; Sarah Spiegel
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.
Cancer research 2009;69(17):6915-23.
2009: Laura J Sim-Selley; Paulette B Goforth; Mba U Mba; Timothy L Macdonald; Kevin R Lynch; Sheldon Milstien; Sarah Spiegel; Leslie S Satin; Sandra P Welch; Dana E Selley
Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS.
Journal of neurochemistry 2009;110(4):1191-202.
2009: Roger H Kim; Kazuaki Takabe; Sheldon Milstien; Sarah Spiegel
Export and functions of sphingosine-1-phosphate.
Biochimica et biophysica acta 2009;1791(7):692-6.
2009: Margaret A Park; Teneille Walker; Aditi Pandya Martin; Jeremy C Allegood; Nicollaq Vozhilla; Luni Emdad; Devanand Sarkar; Mohamed Rahmani; Martin Graf; Adly Yacoub; Constantinos Koumenis; Sarah Spiegel; David T Curiel; Christina Voelkel Johnson; Steven Grant; Paul B Fisher; Paul Dent
MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.
Molecular cancer therapeutics 2009;8(5):1280-91.
2009: Michael Maceyka; Sheldon Milstien; Sarah Spiegel
Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling.
Journal of lipid research 2009;50 Suppl():S272-6.
2009: Barbara S Paugh; Lauren Bryan; Steven W Paugh; Katarzyna M Wilczynska; Silvina M Alvarez; Sandeep K Singh; Dmitri Kapitonov; Hanna Rokita; Sarah Wright; Irene Griswold-Prenner; Sheldon Milstien; Sarah Spiegel; Tomasz Kordula
Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells.
The Journal of biological chemistry 2009;284(6):3408-17.
2008: Margaret A Park; Guo Zhang; Aditi Pandya Martin; Hossein Hamed; Clint Mitchell; Phillip B Hylemon; Martin Graf; Mohamed Rahmani; Kevin Ryan; Xiang Liu; Sarah Spiegel; James Norris; Paul B Fisher; Steven Grant; Paul Dent
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.
Cancer biology & therapy 2008;7(10):1648-62.
2008: Lauren Bryan; Barbara S Paugh; Dmitri Kapitonov; Katarzyna M Wilczynska; Silvina M Alvarez; Sandeep K Singh; Sheldon Milstien; Sarah Spiegel; Tomasz Kordula
Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness.
Molecular cancer research : MCR 2008;6(9):1469-77.
2008: Michael Maceyka; Sergio E Alvarez; Sheldon Milstien; Sarah Spiegel
Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration.
Molecular and cellular biology 2008;28(18):5687-97.
2008: Lauren Bryan; Tomasz Kordula; Sarah Spiegel; Sheldon Milstien
Regulation and functions of sphingosine kinases in the brain.
Biochimica et biophysica acta 2008;1781(9):459-66.
2008: Dai Shida; Xianjun Fang; Tomasz Kordula; Kazuaki Takabe; Sandrine Lépine; Sergio E Alvarez; Sheldon Milstien; Sarah Spiegel
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Cancer research 2008;68(16):6569-77.
2008: Steven W Paugh; Barbara S Paugh; Mohamed Rahmani; Dmitri Kapitonov; Jorge A Almenara; Tomasz Kordula; Sheldon Milstien; Jeffrey K Adams; Robert E Zipkin; Steven Grant; Sarah Spiegel
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
Blood 2008;112(4):1382-91.
2008: Dai Shida; Kazuaki Takabe; Dmitri Kapitonov; Sheldon Milstien; Sarah Spiegel
Targeting SphK1 as a new strategy against cancer.
Current drug targets 2008;9(8):662-73.
2008: David R Gude; Sergio E Alvarez; Steven W Paugh; Poulami Mitra; JiaDe Yu; Rachael Griffiths; Suzanne E Barbour; Sheldon Milstien; Sarah Spiegel
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(8):2629-38.
2008: Deborah A Lebman; Sarah Spiegel
Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling.
Journal of lipid research 2008;49(7):1388-94.
2008: Kazuaki Takabe; Steven W Paugh; Sheldon Milstien; Sarah Spiegel
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.
Pharmacological reviews 2008;60(2):181-95.
2008: Anna V Miller; Sergio E Alvarez; Sarah Spiegel; Deborah A Lebman
Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells.
Molecular and cellular biology 2008;28(12):4142-51.
2008: Margaret A Park; Adly Yacoub; Devanand Sarkar; Luni Emdad; Mohamed Rahmani; Sarah Spiegel; Constantinos Koumenis; Martin Graf; David T Curiel; Steven Grant; Paul B Fisher; Paul Dent
PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells.
Autophagy 2008;4(4):513-5.
2008: Carole A Oskeritzian; Sergio E Alvarez; Nitai C Hait; Megan M Price; Sheldon Milstien; Sarah Spiegel
Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions.
Blood 2008;111(8):4193-200.
2008: Margaret A Park; Adly Yacoub; Mohamed Rahmani; Guo Zhang; Lori Hart; Michael P Hagan; Stuart K Calderwood; Michael Y Sherman; Constantinos Koumenis; Sarah Spiegel; Ching-Shih Chen; Martin Graf; David T Curiel; Paul B Fisher; Steven Grant; Paul Dent
OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells.
Molecular pharmacology 2008;73(4):1168-84.
2008: John J Ryan; Sarah Spiegel
The role of sphingosine-1-phosphate and its receptors in asthma.
Drug news & perspectives 2008;21(2):89-96.
2008: Adly Yacoub; Margaret A Park; Pankaj Gupta; Mohamed Rahmani; Guo Zhang; Hossein Hamed; David Hanna; Devanand Sarkar; Irina Lebedeva; Luni Emdad; Moira Sauane; Nicollaq Vozhilla; Sarah Spiegel; Constantinos Koumenis; Martin Graf; David T Curiel; Steven Grant; Paul B Fisher; Paul Dent
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells.
Molecular cancer therapeutics 2008;7(2):297-313.
2008: Barbara S Paugh; Steven W Paugh; Lauren Bryan; Dmitri Kapitonov; Katarzyna M Wilczynska; Sunita M Gopalan; Hanna Rokita; Sheldon Milstien; Sarah Spiegel; Tomasz Kordula
EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(2):455-65.
2007: Hervé Le Stunff; Paola Giussani; Michael Maceyka; Sandrine Lépine; Sheldon Milstien; Sarah Spiegel
Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2.
The Journal of biological chemistry 2007;282(47):34372-80.
2007: Heidi Sankala; Nitai C Hait; Steven W Paugh; Dai Shida; Sandrine Lépine; Lynne W Elmore; Paul Dent; Sheldon Milstien; Sarah Spiegel
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin.
Cancer research 2007;67(21):10466-74.
2007: Rochelle P Coelho; Shawn G Payne; Robert Bittman; Sarah Spiegel; Carmen Sato-Bigbee
The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors.
The Journal of pharmacology and experimental therapeutics 2007;323(2):626-35.
2007: Sergio E Alvarez; Sheldon Milstien; Sarah Spiegel
Autocrine and paracrine roles of sphingosine-1-phosphate.
Trends in endocrinology and metabolism: TEM 2007;18(8):300-7.
2007: Kenneth R Watterson; David A Lanning; Robert F Diegelmann; Sarah Spiegel
Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2007;15(5):607-16.
2007: Carole A Oskeritzian; Sheldon Milstien; Sarah Spiegel
Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis.
Pharmacology & therapeutics 2007;115(3):390-9.
2007: Kenneth R Watterson; Krystina M Berg; Dmitri Kapitonov; Shawn G Payne; Amy S Miner; Robert Bittman; Sheldon Milstien; Paul Ratz; Sarah Spiegel
Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2818-28.
2007: Nitai C Hait; Andrea Bellamy; Sheldon Milstien; Tomasz Kordula; Sarah Spiegel
Sphingosine kinase type 2 activation by ERK-mediated phosphorylation.
The Journal of biological chemistry 2007;282(16):12058-65.
2007: Sheldon Milstien; David Gude; Sarah Spiegel
Sphingosine 1-phosphate in neural signalling and function.
Acta paediatrica (Oslo, Norway : 1992). Supplement 2007;96(455):40-3.
2007: Poulami Mitra; Michael Maceyka; Shawn G Payne; Nadia F Lamour; Sheldon Milstien; Charles E Chalfant; Sarah Spiegel
Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells.
FEBS letters 2007;581(4):735-40.
2007: Shawn G Payne; Carole A Oskeritzian; Rachael Griffiths; Preeti Subramanian; Suzanne E Barbour; Charles E Chalfant; Sheldon Milstien; Sarah Spiegel
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
Blood 2007;109(3):1077-85.
2007: Sarah Spiegel; Sheldon Milstien
Functions of the multifaceted family of sphingosine kinases and some close relatives.
The Journal of biological chemistry 2007;282(4):2125-9.
2007: Michael Maceyka; Sheldon Milstien; Sarah Spiegel
Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate.
Circulation research 2007;100(1):7-9.
2007: Poulami Mitra; Shawn G Payne; Sheldon Milstien; Sarah Spiegel
A rapid and sensitive method to measure secretion of sphingosine-1-phosphate.
Methods in enzymology 2007;434():257-64.
2007: Michael Maceyka; Sheldon Milstien; Sarah Spiegel
Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo.
Methods in enzymology 2007;434():243-56.
2006: Nitai C Hait; Carole A Oskeritzian; Steven W Paugh; Sheldon Milstien; Sarah Spiegel
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.
Biochimica et biophysica acta 2006;1758(12):2016-26.
2006: Poulami Mitra; Carole A Oskeritzian; Shawn G Payne; Michael A Beaven; Sheldon Milstien; Sarah Spiegel
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16394-9.
2006: Sharareh Movafagh; John P Hobson; Sarah Spiegel; Hynda K Kleinman; Zofia Zukowska
Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(11):1924-6.
2006: Paola Giussani; Michael Maceyka; Hervé Le Stunff; Aki Mikami; Sandrine Lépine; Elaine Wang; Samuel Kelly; Alfred H Merrill; Sheldon Milstien; Sarah Spiegel
Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.
Molecular and cellular biology 2006;26(13):5055-69.
2006: Steven W Paugh; Michael P Cassidy; Hengjun He; Sheldon Milstien; Laura J Sim-Selley; Sarah Spiegel; Dana E Selley
Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor.
Molecular pharmacology 2006;70(1):41-50.
2006: Sheldon Milstien; Sarah Spiegel
Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics.
Cancer cell 2006;9(3):148-50.
2006: Roberto R Rosato; Sonia C Maggio; Jorge A Almenara; Shawn G Payne; Peter Atadja; Sarah Spiegel; Paul Dent; Steven Grant
The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide.
Molecular pharmacology 2006;69(1):216-25.
2005: Paul Dent; Youwen Fang; Seema Gupta; Elaine Studer; Clint Mitchell; Sarah Spiegel; Phillip B Hylemon
Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.
Hepatology (Baltimore, Md.) 2005;42(6):1291-9.
2005: Kiyomi Mizugishi; Tadashi Yamashita; Ana Olivera; Georgina F Miller; Sarah Spiegel; Richard L Proia
Essential role for sphingosine kinases in neural and vascular development.
Molecular and cellular biology 2005;25(24):11113-21.
2005: Harsimran S Saini; Rochelle P Coelho; Sravan K Goparaju; Puneet S Jolly; Michael Maceyka; Sarah Spiegel; Carmen Sato-Bigbee
Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors.
Journal of neurochemistry 2005;95(5):1298-310.
2005: Sarah Spiegel; Sheldon Milstien
Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells.
Biochemical Society transactions 2005;33(Pt 6):1362-5.
2005: Michael Maceyka; Heidi Sankala; Nitai C Hait; Hervé Le Stunff; Hong Liu; Rachelle E Toman; Claiborne Collier; Min Zhang; Leslie S Satin; Alfred H Merrill; Sheldon Milstien; Sarah Spiegel
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.
The Journal of biological chemistry 2005;280(44):37118-29.
2005: Charles E Chalfant; Sarah Spiegel
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling.
Journal of cell science 2005;118(Pt 20):4605-12.
2005: Sukumar Sarkar; Michael Maceyka; Nitai C Hait; Steven W Paugh; Heidi Sankala; Sheldon Milstien; Sarah Spiegel
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.
FEBS letters 2005;579(24):5313-7.
2005: Michael Maceyka; Sheldon Milstien; Sarah Spiegel
Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics.
Prostaglandins & other lipid mediators 2005;77(1-4):15-22.
2005: Nitai C Hait; Sukumar Sarkar; Hervé Le Stunff; Aki Mikami; Michael Maceyka; Sheldon Milstien; Sarah Spiegel
Role of sphingosine kinase 2 in cell migration toward epidermal growth factor.
The Journal of biological chemistry 2005;280(33):29462-9.
2005: Vania Hinkovska-Galcheva; Laurence A Boxer; Andrei L Kindzelskii; Miki Hiraoka; Akira Abe; Sravan Goparju; Sarah Spiegel; Howard R Petty; James A Shayman
Ceramide 1-phosphate, a mediator of phagocytosis.
The Journal of biological chemistry 2005;280(28):26612-21.
2005: Puneet S Jolly; Meryem Bektas; Kenneth R Watterson; Heidi Sankala; Shawn G Payne; Sheldon Milstien; Sarah Spiegel
Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.
Blood 2005;105(12):4736-42.
2005: Farida Safadi-Chamberlain; Li-Ping Wang; Shawn G Payne; Chang-Uk Lim; Suzanne Stratford; Jose Antonio Chavez; Michael H Fox; Sarah Spiegel; Scott A Summers
Effect of a membrane-targeted sphingosine kinase 1 on cell proliferation and survival.
The Biochemical journal 2005;388(Pt 3):827-34.
2005: Meryem Bektas; Shawn G Payne; Hong Liu; Sravan K Goparaju; Sheldon Milstien; Sarah Spiegel
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells.
The Journal of cell biology 2005;169(5):801-11.
2005: Jörg-Dieter Schulzke; Alfred H Gitter; Joachim Mankertz; Sarah Spiegel; U Seidler; Salah Amasheh; M Saitou; S Tsukita; Michael Fromm
Epithelial transport and barrier function in occludin-deficient mice.
Biochimica et biophysica acta 2005;1669(1):34-42.
2005: Sravan K Goparaju; Puneet S Jolly; Kenneth R Watterson; Meryem Bektas; Sergio Alvarez; Sukumar Sarkar; Lin Mel; Isao Ishii; Jerold Chun; Sheldon Milstien; Sarah Spiegel
The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation.
Molecular and cellular biology 2005;25(10):4237-49.
2005: Mohamed Rahmani; Erin Reese; Yun Dai; Cheryl Bauer; Shawn G Payne; Paul Dent; Sarah Spiegel; Steven Grant
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.
Cancer research 2005;65(6):2422-32.
2005: Kenneth R Watterson; Paul Ratz; Sarah Spiegel
The role of sphingosine-1-phosphate in smooth muscle contraction.
Cellular signalling 2005;17(3):289-98.
2005: Sylvie Coursol; Hervé Le Stunff; Daniel V Lynch; Simon Gilroy; Sarah M Assmann; Sarah Spiegel
Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture.
Plant physiology 2005;137(2):724-37.
2005: Meryem Bektas; Puneet S Jolly; Carola Müller; Jürgen Eberle; Sarah Spiegel; Christoph C Geilen
Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression.
Oncogene 2005;24(1):178-87.
2004: Maria Allende; Teiji Sasaki; Hiromichi Kawai; Ana Olivera; Yide Mi; Gerhild van Echten-Deckert; Richard Hajdu; Mark J Rosenbach; Carol Ann Keohane; Suzanne Mandala; Sarah Spiegel; Richard L Proia
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.
The Journal of biological chemistry 2004;279(50):52487-92.
2004: Shawn G Payne; Sheldon Milstien; Suzanne E Barbour; Sarah Spiegel
Modulation of adaptive immune responses by sphingosine-1-phosphate.
Seminars in cell & developmental biology 2004;15(5):521-7.
2004: Hervé Le Stunff; Aki Mikami; Paola Giussani; John P Hobson; Puneet S Jolly; Sheldon Milstien; Sarah Spiegel
Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis.
The Journal of biological chemistry 2004;279(33):34290-7.
2004: Rachelle E Toman; Shawn G Payne; Kenneth R Watterson; Michael Maceyka; Norman H Lee; Sheldon Milstien; John W Bigbee; Sarah Spiegel
Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension.
The Journal of cell biology 2004;166(3):381-92.
2004: Hervé Le Stunff; Sheldon Milstien; Sarah Spiegel
Generation and metabolism of bioactive sphingosine-1-phosphate.
Journal of cellular biochemistry 2004;92(5):882-99.
2004: Michael Maceyka; Victor E Nava; Sheldon Milstien; Sarah Spiegel
Aminoacylase 1 is a sphingosine kinase 1-interacting protein.
FEBS letters 2004;568(1-3):30-4.
2004: Puneet S Jolly; Meryem Bektas; Ana Olivera; Claudia Gonzalez-Espinosa; Richard L Proia; Juan Rivera; Sheldon Milstien; Sarah Spiegel
Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis.
The Journal of experimental medicine 2004;199(7):959-70.
2004: Sonia C Maggio; Roberto R Rosato; Lora B Kramer; Yun Dai; Mohamed Rahmani; David S Paik; Ann C Czarnik; Shawn G Payne; Sarah Spiegel; Steven Grant
The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.
Cancer research 2004;64(7):2590-600.
2004: Seema Gupta; Ramesh Natarajan; Shawn G Payne; Elaine Studer; Sarah Spiegel; Paul Dent; Phillip B Hylemon
Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation.
The Journal of biological chemistry 2004;279(7):5821-8.
2004: Meryem Bektas; Sarah Spiegel
Glycosphingolipids and cell death.
Glycoconjugate journal 2004;20(1):39-47.
2003: Sarah Spiegel; Sheldon Milstien
Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways.
Biochemical Society transactions 2003;31(Pt 6):1216-9.
2003: Ana Olivera; Hans M Rosenfeldt; Meryem Bektas; Fang Wang; Isao Ishii; Jerold Chun; Sheldon Milstien; Sarah Spiegel
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors.
The Journal of biological chemistry 2003;278(47):46452-60.
2003: Steven W Paugh; Shawn G Payne; Suzanne E Barbour; Sheldon Milstien; Sarah Spiegel
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.
FEBS letters 2003;554(1-2):189-93.
2003: Meryem Bektas; Larry S Barak; Puneet S Jolly; Hong Liu; Kevin R Lynch; Emanuela Lacana; Ki-Beom Suhr; Sheldon Milstien; Sarah Spiegel
The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.
Biochemistry 2003;42(42):12181-91.
2003: Hong Liu; Rachelle E Toman; Sravan K Goparaju; Michael Maceyka; Victor E Nava; Heidi Sankala; Shawn G Payne; Meryem Bektas; Isao Ishii; Jerold Chun; Sheldon Milstien; Sarah Spiegel
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis.
The Journal of biological chemistry 2003;278(41):40330-6.
2003: Benjamin J Pettus; Alicja Bielawska; Sarah Spiegel; Patrick Roddy; Yusuf A Hannun; Charles E Chalfant
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.
The Journal of biological chemistry 2003;278(40):38206-13.
2003: Hans M Rosenfeldt; Yassine Amrani; Kenneth R Watterson; Karnam S Murthy; Reynold A Panettieri; Sarah Spiegel
Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1789-99.
2003: Diana Escalante-Alcalde; Lidia Hernandez; Hervé Le Stunff; Ryu Maeda; Hyun-Shik Lee; Vicki A Sciorra; Ira O Daar; Sarah Spiegel; Andrew J Morris; Colin L Stewart
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning.
Development (Cambridge, England) 2003;130(19):4623-37.
2003: Meryem Bektas; Puneet S Jolly; Sheldon Milstien; Sarah Spiegel
A specific ceramide kinase assay to measure cellular levels of ceramide.
Analytical biochemistry 2003;320(2):259-65.
2003: Kenneth R Watterson; Heidi Sankala; Sheldon Milstien; Sarah Spiegel
Pleiotropic actions of sphingosine-1-phosphate.
Progress in lipid research 2003;42(4):344-57.
2003: Sylvie Coursol; Liu-Min Fan; Hervé Le Stunff; Sarah Spiegel; Simon Gilroy; Sarah M Assmann
Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins.
Nature 2003;423(6940):651-4.
2003: Claudia Gonzalez-Espinosa; Sandra Odom; Ana Olivera; John P Hobson; Maria Eugenia Cid Martinez; Antonio J Oliveira-dos-Santos; Lillian Barra; Sarah Spiegel; Josef M Penninger; Juan Rivera
Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells.
The Journal of experimental medicine 2003;197(11):1453-65.
2003: Sarah Spiegel; Sheldon Milstien
Sphingosine-1-phosphate: an enigmatic signalling lipid.
Nature reviews. Molecular cell biology 2003;4(5):397-407.
2003: K Kimura; M Markowski; Lisa C Edsall; Sarah Spiegel; Edward P Gelmann
Role of ceramide in mediating apoptosis of irradiated LNCaP prostate cancer cells.
Cell death and differentiation 2003;10(2):240-8.
2002: Michael Maceyka; Shawn G Payne; Sheldon Milstien; Sarah Spiegel
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.
Biochimica et biophysica acta 2002;1585(2-3):193-201.
2002: Victor E Nava; John P Hobson; Shvetha Murthy; Sheldon Milstien; Sarah Spiegel
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells.
Experimental cell research 2002;281(1):115-27.
2002: Shawn G Payne; Sheldon Milstien; Sarah Spiegel
Sphingosine-1-phosphate: dual messenger functions.
FEBS letters 2002;531(1):54-7.
2002: Hervé Le Stunff; Ismael Galve-Roperh; Courtney Peterson; Sheldon Milstien; Sarah Spiegel
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis.
The Journal of cell biology 2002;158(6):1039-49.
2002: Emanuela Lacaná; Michael Maceyka; Sheldon Milstien; Sarah Spiegel
Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity.
The Journal of biological chemistry 2002;277(36):32947-53.
2002: Puneet S Jolly; Hans M Rosenfeldt; Sheldon Milstien; Sarah Spiegel
The roles of sphingosine-1-phosphate in asthma.
Molecular immunology 2002;38(16-18):1239-45.
2002: Sarah Spiegel; Richard Kolesnick
Sphingosine 1-phosphate as a therapeutic agent.
Leukemia 2002;16(9):1596-602.
2002: Rachelle E Toman; Sarah Spiegel
Lysophospholipid receptors in the nervous system.
Neurochemical research 2002;27(7-8):619-27.
2002: Sarah Spiegel; Sheldon Milstien
Sphingosine 1-phosphate, a key cell signaling molecule.
The Journal of biological chemistry 2002;277(29):25851-4.
2002: Hervé Le Stunff; Courtney Peterson; Hong Liu; Sheldon Milstien; Sarah Spiegel
Sphingosine-1-phosphate and lipid phosphohydrolases.
Biochimica et biophysica acta 2002;1582(1-3):8-17.
2002: Rachelle E Toman; Vilen A Movsesyan; Shvetha K Murthy; Sheldon Milstien; Sarah Spiegel; Alan Faden
Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis.
Journal of neuroscience research 2002;68(3):323-30.
2002: Sarah Spiegel; Denis English; Sheldon Milstien
Sphingosine 1-phosphate signaling: providing cells with a sense of direction.
Trends in cell biology 2002;12(5):236-42.
2002: Lewis R Vann; Shawn G Payne; Lisa C Edsall; Sharon Twitty; Sarah Spiegel; Sheldon Milstien
Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells.
The Journal of biological chemistry 2002;277(15):12649-56.
2002: Christelle Benaud; Michael D Oberst; John P Hobson; Sarah Spiegel; Robert B Dickson; Chen-Yong Lin
Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase.
The Journal of biological chemistry 2002;277(12):10539-46.
2002: Hervé Le Stunff; Courtney Peterson; Rosemary Thornton; Sheldon Milstien; Suzanne Mandala; Sarah Spiegel
Characterization of murine sphingosine-1-phosphate phosphohydrolase.
The Journal of biological chemistry 2002;277(11):8920-7.
2002: Steven Grant; Sarah Spiegel
A chicken-or-egg conundrum in apoptosis: which comes first? Ceramide or PKCdelta?
The Journal of clinical investigation 2002;109(6):717-9.
2002: Hong Liu; Debyani Chakravarty; Michael Maceyka; Sheldon Milstien; Sarah Spiegel
Sphingosine kinases: a novel family of lipid kinases.
Progress in nucleic acid research and molecular biology 2002;71():493-511.
2001: Hans M Rosenfeldt; John P Hobson; Michael Maceyka; Ana Olivera; Victor E Nava; Sheldon Milstien; Sarah Spiegel
EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2649-59.
2001: Hans M Rosenfeldt; John P Hobson; Sheldon Milstien; Sarah Spiegel
The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility.
Biochemical Society transactions 2001;29(Pt 6):836-9.
2001: B Kleuser; Michael Maceyka; Sheldon Milstien; Sarah Spiegel
Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor.
FEBS letters 2001;503(1):85-90.
2001: Ana Olivera; Sarah Spiegel
Sphingosine kinase: a mediator of vital cellular functions.
Prostaglandins & other lipid mediators 2001;64(1-4):123-34.
2001: John P Hobson; Hans M Rosenfeldt; L S Barak; Ana Olivera; S Poulton; Marc G Caron; Sheldon Milstien; Sarah Spiegel
Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.
Science (New York, N.Y.) 2001;291(5509):1800-3.
2001: Lisa C Edsall; Olivier Cuvillier; Sharon Twitty; Sarah Spiegel; Sheldon Milstien
Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells.
Journal of neurochemistry 2001;76(5):1573-84.
2001: RL Malek; R E Toman; Lisa C Edsall; S Wong; J Chiu; C A Letterle; James R Van Brocklyn; Sheldon Milstien; Sarah Spiegel; Norman H Lee
Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors.
The Journal of biological chemistry 2001;276(8):5692-9.
2001: Rachelle E Toman; Sheldon Milstien; Sarah Spiegel
Sphingosine-1-phosphate: an emerging therapeutic target.
Expert opinion on therapeutic targets 2001;5(1):109-23.
2001: Olivier Cuvillier; Victor E Nava; S K Murthy; Lisa C Edsall; Thierry Levade; Sheldon Milstien; Sarah Spiegel
Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.
Cell death and differentiation 2001;8(2):162-71.
2000: Rachelle E Toman; Sarah Spiegel; Alan Faden
Role of ceramide in neuronal cell death and differentiation.
Journal of neurotrauma 2000;17(10):891-8.
2000: Yujing Liu; Ryuichi Wada; Tadashi Yamashita; Yide Mi; Chu-Xia Deng; John P Hobson; Hans M Rosenfeldt; Victor E Nava; Sung-Suk Chae; Meng-Jer Lee; Catherine H Liu; timothy hla; Sarah Spiegel; Richard L Proia
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.
The Journal of clinical investigation 2000;106(8):951-61.
2000: Victor E Nava; Olivier Cuvillier; Lisa C Edsall; K Kimura; Sheldon Milstien; Edward P Gelmann; Sarah Spiegel
Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells.
Cancer research 2000;60(16):4468-74.
2000: Suzanne Mandala; Rosemary Thornton; I Galve-Roperh; S Poulton; Courtney Peterson; Ana Olivera; James Bergstrom; Myra B Kurtz; Sarah Spiegel
Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7859-64.
2000: Sarah Spiegel; Sheldon Milstien
Sphingosine-1-phosphate: signaling inside and out.
FEBS letters 2000;476(1-2):55-7.
2000: Hong Liu; M Sugiura; Victor E Nava; Lisa C Edsall; K Kono; S Poulton; Sheldon Milstien; Takafumi Kohama; Sarah Spiegel
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.
The Journal of biological chemistry 2000;275(26):19513-20.
2000: Olivier Cuvillier; Lisa C Edsall; Sarah Spiegel
Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells.
The Journal of biological chemistry 2000;275(21):15691-700.
2000: Lewis R Vann; Sharon Twitty; Sarah Spiegel; Sheldon Milstien
Divergence in regulation of nitric-oxide synthase and its cofactor tetrahydrobiopterin by tumor necrosis factor-alpha. Ceramide potentiates nitric oxide synthesis without affecting GTP cyclohydrolase I activity.
The Journal of biological chemistry 2000;275(18):13275-81.
2000: Victor E Nava; E Lacana; S Poulton; Hong Liu; M Sugiura; K Kono; Sheldon Milstien; Takafumi Kohama; Sarah Spiegel
Functional characterization of human sphingosine kinase-1.
FEBS letters 2000;473(1):81-4.
2000: James R Van Brocklyn; MH Gräler; G Bernhardt; John P Hobson; Martin Lipp; Sarah Spiegel
Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6.
Blood 2000;95(8):2624-9.
2000: Sarah Spiegel; Sheldon Milstien
Functions of a new family of sphingosine-1-phosphate receptors.
Biochimica et biophysica acta 2000;1484(2-3):107-16.
2000: Sarah Spiegel
Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.
Annals of the New York Academy of Sciences 2000;905():54-60.
2000: Lisa C Edsall; Lewis R Vann; Sheldon Milstien; Sarah Spiegel
Enzymatic method for measurement of sphingosine 1-phosphate.
Methods in enzymology 2000;312():9-16.
2000: Ana Olivera; K D Barlow; Sarah Spiegel
Assaying sphingosine kinase activity.
Methods in enzymology 2000;311():215-23.
1999: Fudi Wang; James R Van Brocklyn; Lisa C Edsall; Victor E Nava; Sarah Spiegel
Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors.
Cancer research 1999;59(24):6185-91.
1999: Fudi Wang; James R Van Brocklyn; John P Hobson; Sharareh Movafagh; Z Zukowska-Grojec; Sheldon Milstien; Sarah Spiegel
Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis.
The Journal of biological chemistry 1999;274(50):35343-50.
1999: Olivier Cuvillier; E Mayhew; AS Janoff; Sarah Spiegel
Liposomal ET-18-OCH(3) induces cytochrome c-mediated apoptosis independently of CD95 (APO-1/Fas) signaling.
Blood 1999;94(10):3583-92.
1999: Ana Olivera; Takafumi Kohama; Lisa C Edsall; Victor E Nava; Olivier Cuvillier; S Poulton; Sarah Spiegel
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.
The Journal of cell biology 1999;147(3):545-58.
1999: Ana Olivera; Lisa C Edsall; S Poulton; Andrius Kazlauskas; Sarah Spiegel
Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(12):1593-600.
1999: Peter D Burbelo; D M Snow; W Bahou; Sarah Spiegel
MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9083-8.
1999: Lisa C Edsall; Sarah Spiegel
Enzymatic measurement of sphingosine 1-phosphate.
Analytical biochemistry 1999;272(1):80-6.
1999: Sarah Spiegel; Zoltan Olah; Olivier Cuvillier; Lisa C Edsall; AS Janoff
Differential effects of free and liposome-associated 1-O-octadecyl-2-O-methylglycerophosphocholine on protein kinase C.
FEBS letters 1999;454(1-2):137-41.
1999: Catherine H Liu; Shobha Thangada; Meng-Jer Lee; James R Van Brocklyn; Sarah Spiegel; timothy hla
Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1.
Molecular biology of the cell 1999;10(4):1179-90.
1999: K Kimura; C Bowen; Sarah Spiegel; Edward P Gelmann
Tumor necrosis factor-alpha sensitizes prostate cancer cells to gamma-irradiation-induced apoptosis.
Cancer research 1999;59(7):1606-14.
1999: Sarah Spiegel
Sphingosine 1-phosphate: a prototype of a new class of second messengers.
Journal of leukocyte biology 1999;65(3):341-4.
1999: Fudi Wang; K Nohara; Ana Olivera; Erik W Thompson; Sarah Spiegel
Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate.
Experimental cell research 1999;247(1):17-28.
1999: James R Van Brocklyn; Z Tu; Lisa C Edsall; R R Schmidt; Sarah Spiegel
Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.
The Journal of biological chemistry 1999;274(8):4626-32.
1998: Lisa C Edsall; James R Van Brocklyn; Olivier Cuvillier; B Kleuser; Sarah Spiegel
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.
Biochemistry 1998;37(37):12892-8.
1998: Takafumi Kohama; Ana Olivera; Lisa C Edsall; M M Nagiec; R Dickson; Sarah Spiegel
Molecular cloning and functional characterization of murine sphingosine kinase.
The Journal of biological chemistry 1998;273(37):23722-8.
1998: C Bowen; Sarah Spiegel; Edward P Gelmann
Radiation-induced apoptosis mediated by retinoblastoma protein.
Cancer research 1998;58(15):3275-81.
1998: James R Van Brocklyn; Meng-Jer Lee; R Menzeleev; Ana Olivera; Lisa C Edsall; Olivier Cuvillier; D M Thomas; Peter J Coopman; Shobha Thangada; Catherine H Liu; timothy hla; Sarah Spiegel
Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival.
The Journal of cell biology 1998;142(1):229-40.
1998: Sarah Spiegel; Olivier Cuvillier; Lisa C Edsall; Takafumi Kohama; R Menzeleev; Zoltan Olah; Ana Olivera; G Pirianov; D M Thomas; Z Tu; James R Van Brocklyn; Fudi Wang
Sphingosine-1-phosphate in cell growth and cell death.
Annals of the New York Academy of Sciences 1998;845():11-8.
1998: Ana Olivera; Takafumi Kohama; Z Tu; Sheldon Milstien; Sarah Spiegel
Purification and characterization of rat kidney sphingosine kinase.
The Journal of biological chemistry 1998;273(20):12576-83.
1998: B Kleuser; Olivier Cuvillier; Sarah Spiegel
1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.
Cancer research 1998;58(9):1817-24.
1998: L Qiao; Alan P Kozikowski; Ana Olivera; Sarah Spiegel
Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate--caged SPP.
Bioorganic & medicinal chemistry letters 1998;8(7):711-4.
1998: Meng-Jer Lee; James R Van Brocklyn; Shobha Thangada; Catherine H Liu; A R Hand; R Menzeleev; Sarah Spiegel; timothy hla
Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.
Science (New York, N.Y.) 1998;279(5356):1552-5.
1998: A Berger; C M Cultaro; S Segal; Sarah Spiegel
The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix-loop-helix-zipper protein.
Biochimica et biophysica acta 1998;1390(2):225-36.
1998: Muchieh Yu; H Sato; Motoharu Seiki; Sarah Spiegel; Erik W Thompson
Elevated cyclic AMP suppresses ConA-induced MT1-MMP expression in MDA-MB-231 human breast cancer cells.
Clinical & experimental metastasis 1998;16(2):185-91.
1998: Olivier Cuvillier; Dean S Rosenthal; Mark E Smulson; Sarah Spiegel
Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes.
The Journal of biological chemistry 1998;273(5):2910-6.
1998: Suzanne Mandala; Rosemary Thornton; Z Tu; Myra B Kurtz; J Nickels; J Broach; R Menzeleev; Sarah Spiegel
Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(1):150-5.
1998: Ana Olivera; Sarah Spiegel
Sphingosine kinase. Assay and product analysis.
Methods in molecular biology (Clifton, N.J.) 1998;105():233-42.
1998: Sarah Spiegel; Olivier Cuvillier; Lisa C Edsall; Takafumi Kohama; R Menzeleev; Ana Olivera; D Thomas; Z Tu; James R Van Brocklyn; Fudi Wang
Roles of sphingosine-1-phosphate in cell growth, differentiation, and death.
Biochemistry. Biokhimii͡a 1998;63(1):69-73.
1997: R A Rius; Lisa C Edsall; Sarah Spiegel
Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors.
FEBS letters 1997;417(2):173-6.
1997: Ana Olivera; A Romanowski; C S Rani; Sarah Spiegel
Differential effects of sphingomyelinase and cell-permeable ceramide analogs on proliferation of Swiss 3T3 fibroblasts.
Biochimica et biophysica acta 1997;1348(3):311-23.
1997: Lisa C Edsall; G G Pirianov; Sarah Spiegel
Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):6952-60.
1997: Muchieh Yu; H Sato; Motoharu Seiki; Sarah Spiegel; Erik W Thompson
Calcium influx inhibits MT1-MMP processing and blocks MMP-2 activation.
FEBS letters 1997;412(3):568-72.
1997: VA Blakesley; D Beitner-Johnson; J R Van Brocklyn; S Rani; Z Shen-Orr; Bethel Stannard; Sarah Spiegel; Derek LeRoith
Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk.
The Journal of biological chemistry 1997;272(26):16211-5.
1997: Fudi Wang; C D Nobes; Alan Hall; Sarah Spiegel
Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts.
The Biochemical journal 1997;324 ( Pt 2)():481-8.
1997: C S Rani; Fudi Wang; E Fuior; A Berger; Jianmin Wu; T W Sturgill; D Beitner-Johnson; D LeRoith; L Varticovski; Sarah Spiegel
Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling.
The Journal of biological chemistry 1997;272(16):10777-83.
1996: Fudi Wang; N E Buckley; Ana Olivera; K A Goodemote; Y Su; Sarah Spiegel
Involvement of sphingolipids metabolites in cellular proliferation modulated by ganglioside GM1.
Glycoconjugate journal 1996;13(6):937-45.
1996: Sarah Spiegel; Alfred H Merrill
Sphingolipid metabolism and cell growth regulation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(12):1388-97.
1996: A Berger; Robert Bittman; R R Schmidt; Sarah Spiegel
Structural requirements of sphingosylphosphocholine and sphingosine-1-phosphate for stimulation of activator protein-1 activity.
Molecular pharmacology 1996;50(3):451-7.
1996: Olivier Cuvillier; G Pirianov; B Kleuser; P G Vanek; O A Coso; J Silvio Gutkind; Sarah Spiegel
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate.
Nature 1996;381(6585):800-3.
1996: Sarah Spiegel; Sheldon Milstien
Sphingoid bases and phospholipase D activation.
Chemistry and physics of lipids 1996;80(1-2):27-36.
1996: Sarah Spiegel; D Foster; Richard Kolesnick
Signal transduction through lipid second messengers.
Current opinion in cell biology 1996;8(2):159-67.
1996: Ana Olivera; J Rosenthal; Sarah Spiegel
Effect of acidic phospholipids on sphingosine kinase.
Journal of cellular biochemistry 1996;60(4):529-37.
1995: Sarah Spiegel; Sheldon Milstien
Sphingolipid metabolites: members of a new class of lipid second messengers.
The Journal of membrane biology 1995;146(3):225-37.
1995: A Berger; D Rosenthal; Sarah Spiegel
Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):5885-9.
1995: N E Buckley; Y Su; S Milstien; Sarah Spiegel
The role of calcium influx in cellular proliferation induced by interaction of endogenous ganglioside GM1 with the B subunit of cholera toxin.
Biochimica et biophysica acta 1995;1256(3):275-83.
1995: K A Goodemote; M E Mattie; A Berger; Sarah Spiegel
Involvement of a pertussis toxin-sensitive G protein in the mitogenic signaling pathways of sphingosine 1-phosphate.
The Journal of biological chemistry 1995;270(17):10272-7.
1994: Ana Olivera; J Rosenthal; Sarah Spiegel
Sphingosine kinase from Swiss 3T3 fibroblasts: a convenient assay for the measurement of intracellular levels of free sphingoid bases.
Analytical biochemistry 1994;223(2):306-12.
1994: Ana Olivera; H Zhang; R O Carlson; M E Mattie; R R Schmidt; Sarah Spiegel
Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation.
The Journal of biological chemistry 1994;269(27):17924-30.
1994: Y Su; D Rosenthal; Mark E Smulson; Sarah Spiegel
Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts.
The Journal of biological chemistry 1994;269(23):16512-7.
1994: R O Carlson; D Masco; Gary Brooker; Sarah Spiegel
Endogenous ganglioside GM1 modulates L-type calcium channel activity in N18 neuroblastoma cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1994;14(4):2272-81.
1994: M Mattie; Gary Brooker; Sarah Spiegel
Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.
The Journal of biological chemistry 1994;269(5):3181-8.
1994: Sarah Spiegel; Ana Olivera; H Zhang; Erik W Thompson; Y Su; A Berger
Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells.
Breast cancer research and treatment 1994;31(2-3):337-48.
1993: Sarah Spiegel
Sphingosine and sphingosine 1-phosphate in cellular proliferation: relationship with protein kinase C and phosphatidic acid.
Journal of lipid mediators 1993;8(3):169-75.
1993: Ana Olivera; Sarah Spiegel
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens.
Nature 1993;365(6446):557-60.
1993: N N Desai; R O Carlson; M E Mattie; Ana Olivera; N E Buckley; T Seki; Gary Brooker; Sarah Spiegel
Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts.
The Journal of cell biology 1993;121(6):1385-95.
1993: Sarah Spiegel; Ana Olivera; R O Carlson
The role of sphingosine in cell growth regulation and transmembrane signaling.
Advances in lipid research 1993;25():105-29.
1992: Ana Olivera; N E Buckley; Sarah Spiegel
Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts.
The Journal of biological chemistry 1992;267(36):26121-7.
1992: N N Desai; H Zhang; Ana Olivera; M E Mattie; Sarah Spiegel
Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation.
The Journal of biological chemistry 1992;267(32):23122-8.
1992: Ana Olivera; Sarah Spiegel
Ganglioside GM1 and sphingolipid breakdown products in cellular proliferation and signal transduction pathways.
Glycoconjugate journal 1992;9(3):110-7.
1991: N N Desai; Sarah Spiegel
Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines.
Biochemical and biophysical research communications 1991;181(1):361-6.
1991: D Masco; M Van de Walle; Sarah Spiegel
Interaction of ganglioside GM1 with the B subunit of cholera toxin modulates growth and differentiation of neuroblastoma N18 cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(8):2443-52.
1991: H Zhang; N N Desai; Ana Olivera; T Seki; Gary Brooker; Sarah Spiegel
Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.
The Journal of cell biology 1991;114(1):155-67.
1990: H Zhang; N N Desai; J M Murphey; Sarah Spiegel
Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells.
The Journal of biological chemistry 1990;265(34):21309-16.
1990: N E Buckley; G R Matyas; Sarah Spiegel
The bimodal growth response of Swiss 3T3 cells to the B subunit of cholera toxin is independent of the density of its receptor, ganglioside GM1.
Experimental cell research 1990;189(1):13-21.
1990: Sarah Spiegel
Cautionary note on the use of the B subunit of cholera toxin as a ganglioside GM1 probe: detection of cholera toxin A subunit in B subunit preparations by a sensitive adenylate cyclase assay.
Journal of cellular biochemistry 1990;42(3):143-52.
1990: H Zhang; N E Buckley; K Gibson; Sarah Spiegel
Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.
The Journal of biological chemistry 1990;265(1):76-81.
1989: Sarah Spiegel
Inhibition of protein kinase C-dependent cellular proliferation by interaction of endogenous ganglioside GM1 with the B subunit of cholera toxin.
The Journal of biological chemistry 1989;264(28):16512-7.
1989: Sarah Spiegel
Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation.
The Journal of biological chemistry 1989;264(12):6766-72.