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Bruce Spiegelman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
25
Puigserver, Pere
19
Lin, Jiandie
17
sarraf, pasha
14
Handschin, Christoph
13
Mueller, Elisabetta
12
Lowell, Bradford
11
Rhee, James
10
Wu, Zhidan
10
Chin, Sherry
9
Yang, Wenli
9
Ross, Susan
8
Distel, Robert
7
Cooper, Marcus
7
Seale, Patrick
7
Rosen, Evan

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Publications

TOP 3
Kajimura Shingo; Seale Patrick; Kubota Kazuishi; Lunsford Elaine; Frangioni John V; Gygi Steven P; Spiegelman Bruce M
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
Estall Jennifer L; Kahn Mario; Cooper Marcus P; Fisher Ffolliott Martin; Wu Michele K; Laznik Dina; Qu Lishu; Cohen David E; Shulman Gerald I; Spiegelman Bruce M
Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.
Seale Patrick; Kajimura Shingo; Spiegelman Bruce M
Transcriptional control of brown adipocyte development and physiological function--of mice and men.

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All Publications

2009: Kajimura Shingo; Seale Patrick; Kubota Kazuishi; Lunsford Elaine; Frangioni John V; Gygi Steven P; Spiegelman Bruce M
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
Nature 2009;460(7259):1154-8.
2009: Estall Jennifer L; Kahn Mario; Cooper Marcus P; Fisher Ffolliott Martin; Wu Michele K; Laznik Dina; Qu Lishu; Cohen David E; Shulman Gerald I; Spiegelman Bruce M
Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.
Diabetes 2009;58(7):1499-508.
2009: Seale Patrick; Kajimura Shingo; Spiegelman Bruce M
Transcriptional control of brown adipocyte development and physiological function--of mice and men.
Genes & development 2009;23(7):788-97.
2008: Cooper Marcus P; Uldry Marc; Kajimura Shingo; Arany Zoltan; Spiegelman Bruce M
Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130.
The Journal of biological chemistry 2008;283(46):31960-7.
2008: Girnun Geoffrey D; Chen Liang; Silvaggi Jessica; Drapkin Ronny; Chirieac Lucian R; Padera Robert F; Upadhyay Rabi; Vafai Scott B; Weissleder Ralph; Mahmood Umar; Naseri Elnaz; Buckley Stephanie; Li Danan; Force Jeremy; McNamara Kate; Demetri George; Spiegelman Bruce M; Wong Kwok-Kin
Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6478-86.
2008: Walkey Christopher J; Spiegelman Bruce M
A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis.
The Journal of biological chemistry 2008;283(36):24290-4.
2008: Seale Patrick; Bjork Bryan; Yang Wenli; Kajimura Shingo; Chin Sherry; Kuang Shihuan; Scimè Anthony; Devarakonda Srikripa; Conroe Heather M; Erdjument-Bromage Hediye; Tempst Paul; Rudnicki Michael A; Beier David R; Spiegelman Bruce M
PRDM16 controls a brown fat/skeletal muscle switch.
Nature 2008;454(7207):961-7.
2008: Handschin Christoph; Spiegelman Bruce M
The role of exercise and PGC1alpha in inflammation and chronic disease.
Nature 2008;454(7203):463-9.
2008: Kajimura Shingo; Seale Patrick; Tomaru Takuya; Erdjument-Bromage Hediye; Cooper Marcus P; Ruas Jorge L; Chin Sherry; Tempst Paul; Lazar Mitchell A; Spiegelman Bruce M
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
Genes & development 2008;22(10):1397-409.
2008: Calvo Jennifer A; Daniels Thomas G; Wang Xiaomei; Paul Angelika; Lin Jiandie; Spiegelman Bruce M; Stevenson Susan C; Rangwala Shamina M
Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;104(5):1304-12.
2008: Arany Zoltan; Wagner Bridget K; Ma Yanhong; Chinsomboon Jessica; Laznik Dina; Spiegelman Bruce M
Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4721-6.
2008: Arany Zoltan; Foo Shi-Yin; Ma Yanhong; Ruas Jorge L; Bommi-Reddy Archana; Girnun Geoffrey; Cooper Marcus; Laznik Dina; Chinsomboon Jessica; Rangwala Shamina M; Baek Kwan Hyuck; Rosenzweig Anthony; Spiegelman Bruce M
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.
Nature 2008;451(7181):1008-12.
2008: Tontonoz Peter; Spiegelman Bruce M
Fat and beyond: the diverse biology of PPARgamma.
Annual review of biochemistry 2008;77():289-312.
2007: Handschin Christoph; Choi Cheol Soo; Chin Sherry; Kim Sheene; Kawamori Dan; Kurpad Amarnath J; Neubauer Nicole; Hu Jiang; Mootha Vamsi K; Kim Young-Bum; Kulkarni Rohit N; Shulman Gerald I; Spiegelman Bruce M
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.
The Journal of clinical investigation 2007;117(11):3463-74.
2007: Handschin Christoph; Chin Sherry; Li Ping; Liu Fenfen; Maratos-Flier Eleftheria; Lebrasseur Nathan K; Yan Zhen; Spiegelman Bruce M
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.
The Journal of biological chemistry 2007;282(41):30014-21.
2007: Seale Patrick; Kajimura Shingo; Yang Wenli; Chin Sherry; Rohas Lindsay M; Uldry Marc; Tavernier Geneviève; Langin Dominique; Spiegelman Bruce M
Transcriptional control of brown fat determination by PRDM16.
Cell metabolism 2007;6(1):38-54.
2007: Jäger Sibylle; Handschin Christoph; St-Pierre Julie; Spiegelman Bruce M
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12017-22.
2007: Girnun Geoffrey D; Naseri Elnaz; Vafai Scott B; Qu Lishu; Szwaya Jeffrey D; Bronson Roderick; Alberta John A; Spiegelman Bruce M
Synergy between PPARgamma ligands and platinum-based drugs in cancer.
Cancer cell 2007;11(5):395-406.
2007: Rohas Lindsay M; St-Pierre Julie; Uldry Marc; Jäger Sibylle; Handschin Christoph; Spiegelman Bruce M
A fundamental system of cellular energy homeostasis regulated by PGC-1alpha.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):7933-8.
2007: Handschin Christoph; Kobayashi Yvonne M; Chin Sherry; Seale Patrick; Campbell Kevin P; Spiegelman Bruce M
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.
Genes & development 2007;21(7):770-83.
2007: Arany Zoltan; Lebrasseur Nathan; Morris Carl; Smith Eric; Yang Wenli; Ma Yanhong; Chin Sherry; Spiegelman Bruce M
The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle.
Cell metabolism 2007;5(1):35-46.
2007: Spiegelman Bruce M
Transcriptional control of energy homeostasis through the PGC1 coactivators.
Novartis Foundation symposium 2007;286():3-6; discusssion 6-12, 162-3, 196-203.
2007: Spiegelman Bruce M
Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.
Novartis Foundation symposium 2007;287():60-3; discussion 63-9.
2006: Spiegelman Bruce M; Enerbäck Sven
"The adipocyte: a multifunctional cell".
Cell metabolism 2006;4(6):425-7.
2006: Rosen Evan D; Spiegelman Bruce M
Adipocytes as regulators of energy balance and glucose homeostasis.
Nature 2006;444(7121):847-53.
2006: Vianna Claudia R; Huntgeburth Michael; Coppari Roberto; Choi Cheol Soo; Lin Jiandie; Krauss Stefan; Barbatelli Giorgio; Tzameli Iphigenia; Kim Young-Bum; Cinti Saverio; Shulman Gerald I; Spiegelman Bruce M; Lowell Bradford B
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
Cell metabolism 2006;4(6):453-64.
2006: Michalik Liliane; Auwerx Johan; Berger Joel P; Chatterjee V Krishna; Glass Christopher K; Gonzalez Frank J; Grimaldi Paul A; Kadowaki Takashi; Lazar Mitchell A; O'Rahilly Stephen; Palmer Colin N A; Plutzky Jorge; Reddy Janardan K; Spiegelman Bruce M; Staels Bart; Wahli Walter
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
Pharmacological reviews 2006;58(4):726-41.
2006: Handschin Christophe; Spiegelman Bruce M
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.
Endocrine reviews 2006;27(7):728-35.
2006: Cooper Marcus P; Qu Lishu; Rohas Lindsay M; Lin Jiandie; Yang Wenli; Erdjument-Bromage Hediye; Tempst Paul; Spiegelman Bruce M
Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.
Genes & development 2006;20(21):2996-3009.
2006: St-Pierre Julie; Drori Stavit; Uldry Marc; Silvaggi Jessica M; Rhee James; Jäger Sibylle; Handschin Christoph; Zheng Kangni; Lin Jiandie; Yang Wenli; Simon David K; Bachoo Robert; Spiegelman Bruce M
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.
Cell 2006;127(2):397-408.
2006: Sandri Marco; Lin Jiandie; Handschin Christoph; Yang Wenli; Arany Zoltan P; Lecker Stewart H; Goldberg Alfred L; Spiegelman Bruce M
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16260-5.
2006: Wu Zhidan; Huang Xueming; Feng Yajun; Handschin Christoph; Feng Yan; Gullicksen P Scott; Bare Olivia; Labow Mark; Spiegelman Bruce; Stevenson Susan C
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14379-84.
2006: Arany Zoltan; Novikov Mikhail; Chin Sherry; Ma Yanhong; Rosenzweig Anthony; Spiegelman Bruce M
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):10086-91.
2006: Uldry Marc; Yang Wenli; St-Pierre Julie; Lin Jiandie; Seale Patrick; Spiegelman Bruce M
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.
Cell metabolism 2006;3(5):333-41.
2006: Rhee James; Ge Hongfei; Yang Wenli; Fan Melina; Handschin Christoph; Cooper Marcus; Lin Jiandie; Li Cai; Spiegelman Bruce M
Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism.
The Journal of biological chemistry 2006;281(21):14683-90.
2005: Handschin Christoph; Lin Jiandie; Rhee James; Peyer Anne-Kathrin; Chin Sherry; Wu Pei-Hsuan; Meyer Urs A; Spiegelman Bruce M
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.
Cell 2005;122(4):505-15.
2005: Hong Jeong-Ho; Hwang Eun Sook; McManus Michael T; Amsterdam Adam; Tian Yu; Kalmukova Ralitsa; Mueller Elisabetta; Benjamin Thomas; Spiegelman Bruce M; Sharp Phillip A; Hopkins Nancy; Yaffe Michael B
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
Science (New York, N.Y.) 2005;309(5737):1074-8.
2005: Lin Jiandie; Handschin Christoph; Spiegelman Bruce M
Metabolic control through the PGC-1 family of transcription coactivators.
Cell metabolism 2005;1(6):361-70.
2005: Andersen G; Wegner L; Yanagisawa K; Rose C S; Lin J; Glümer C; Drivsholm T; Borch-Johnsen K; Jørgensen T; Hansen T; Spiegelman B M; Pedersen O
Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.
Journal of medical genetics 2005;42(5):402-7.
2005: Arany Zoltan; He Huamei; Lin Jiandie; Hoyer Kirsten; Handschin Christoph; Toka Okan; Ahmad Ferhaan; Matsui Takashi; Chin Sherry; Wu Pei-Hsuan; Rybkin Igor I; Shelton John M; Manieri Monia; Cinti Saverio; Schoen Frederick J; Bassel-Duby Rhonda; Rosenzweig Anthony; Ingwall Joanne S; Spiegelman Bruce M
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.
Cell metabolism 2005;1(4):259-71.
2005: Rodgers Joseph T; Lerin Carlos; Haas Wilhelm; Gygi Steven P; Spiegelman Bruce M; Puigserver Pere
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Nature 2005;434(7029):113-8.
2005: Chen Zhu; Torrens Javier I; Anand Ashim; Spiegelman Bruce M; Friedman Jeffrey M
Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms.
Cell metabolism 2005;1(2):93-106.
2005: Drori Stavit; Girnun Geoffrey D; Tou Liqiang; Szwaya Jeffrey D; Mueller Elisabetta; Xia Kai; Shivdasani Ramesh A; Spiegelman Bruce M
Hic-5 regulates an epithelial program mediated by PPARgamma.
Genes & development 2005;19(3):362-75.
2005: Lin Jiandie; Yang Ruojing; Tarr Paul T; Wu Pei-Hsuan; Handschin Christoph; Li Siming; Yang Wenli; Pei Liming; Uldry Marc; Tontonoz Peter; Newgard Christopher B; Spiegelman Bruce M
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
Cell 2005;120(2):261-73.
2004: Spiegelman Bruce M; Heinrich Reinhart
Biological control through regulated transcriptional coactivators.
Cell 2004;119(2):157-67.
2004: Smith Matthew R; Manola Judith; Kaufman Donald S; George Daniel; Oh William K; Mueller Elisabetta; Slovin Susan; Spiegelman Bruce; Small Eric; Kantoff Philip W
Rosiglitazone versus placebo for men with prostate carcinoma and a rising serum prostate-specific antigen level after radical prostatectomy and/or radiation therapy.
Cancer 2004;101(7):1569-74.
2004: Lin Jiandie; Wu Pei-Hsuan; Tarr Paul T; Lindenberg Katrin S; St-Pierre Julie; Zhang Chen-Yu; Mootha Vamsi K; Jäger Sibylle; Vianna Claudia R; Reznick Richard M; Cui Libin; Manieri Monia; Donovan Mi X; Wu Zhidan; Cooper Marcus P; Fan Melina C; Rohas Lindsay M; Zavacki Ann Marie; Cinti Saverio; Shulman Gerald I; Lowell Bradford B; Krainc Dimitri; Spiegelman Bruce M
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
Cell 2004;119(1):121-35.
2004: Mootha Vamsi K; Handschin Christoph; Arlow Dan; Xie Xiaohui; St Pierre Julie; Sihag Smita; Yang Wenli; Altshuler David; Puigserver Pere; Patterson Nick; Willy Patricia J; Schulman Ira G; Heyman Richard A; Lander Eric S; Spiegelman Bruce M
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6570-5.
2004: Cao Wenhong; Daniel Kiefer W; Robidoux Jacques; Puigserver Pere; Medvedev Alexander V; Bai Xu; Floering Lisa M; Spiegelman Bruce M; Collins Sheila
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
Molecular and cellular biology 2004;24(7):3057-67.
2004: Fan Melina; Rhee James; St-Pierre Julie; Handschin Christoph; Puigserver Pere; Lin Jiandie; Jäeger Sibylle; Erdjument-Bromage Hediye; Tempst Paul; Spiegelman Bruce M
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.
Genes & development 2004;18(3):278-89.
2003: Wallberg Annika E; Yamamura Soichiro; Malik Sohail; Spiegelman Bruce M; Roeder Robert G
Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.
Molecular cell 2003;12(5):1137-49.
2003: Rosen Evan D; Kulkarni Rohit N; Sarraf Pasha; Ozcan Umut; Okada Terumasa; Hsu Chung-Hsin; Eisenman Daniel; Magnuson Mark A; Gonzalez Frank J; Kahn C Ronald; Spiegelman Bruce M
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.
Molecular and cellular biology 2003;23(20):7222-9.
2003: Norris Andrew W; Chen Lihong; Fisher Simon J; Szanto Ildiko; Ristow Michael; Jozsi Alison C; Hirshman Michael F; Rosen Evan D; Goodyear Laurie J; Gonzalez Frank J; Spiegelman Bruce M; Kahn C Ronald
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.
The Journal of clinical investigation 2003;112(4):608-18.
2003: Lin Jiandie; Tarr Paul T; Yang Ruojing; Rhee James; Puigserver Pere; Newgard Christopher B; Spiegelman Bruce M
PGC-1beta in the regulation of hepatic glucose and energy metabolism.
The Journal of biological chemistry 2003;278(33):30843-8.
2003: Yoon J Cliff; Xu Gang; Deeney Jude T; Yang Shao-Nian; Rhee James; Puigserver Pere; Levens Adah R; Yang Ruojing; Zhang Chen-Yu; Lowell Bradford B; Berggren Per-Olof; Newgard Christopher B; Bonner-Weir Susan; Weir Gordon; Spiegelman Bruce M
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.
Developmental cell 2003;5(1):73-83.
2003: Mootha Vamsi K; Lindgren Cecilia M; Eriksson Karl-Fredrik; Subramanian Aravind; Sihag Smita; Lehar Joseph; Puigserver Pere; Carlsson Emma; Ridderstråle Martin; Laurila Esa; Houstis Nicholas; Daly Mark J; Patterson Nick; Mesirov Jill P; Golub Todd R; Tamayo Pablo; Spiegelman Bruce; Lander Eric S; Hirschhorn Joel N; Altshuler David; Groop Leif C
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
Nature genetics 2003;34(3):267-73.
2003: St-Pierre Julie; Lin Jiandie; Krauss Stefan; Tarr Paul T; Yang Ruojing; Newgard Christopher B; Spiegelman Bruce M
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells.
The Journal of biological chemistry 2003;278(29):26597-603.
2003: Burstein Harold J; Demetri George D; Mueller Elisabetta; Sarraf Pasha; Spiegelman Bruce M; Winer Eric P
Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study.
Breast cancer research and treatment 2003;79(3):391-7.
2003: Handschin Christoph; Rhee James; Lin Jiandie; Tarr Paul T; Spiegelman Bruce M
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7111-6.
2003: Puigserver Pere; Rhee James; Donovan Jerry; Walkey Christopher J; Yoon J Cliff; Oriente Francesco; Kitamura Yukari; Altomonte Jennifer; Dong Hengjiang; Accili Domenico; Spiegelman Bruce M
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
Nature 2003;423(6939):550-5.
2003: Rhee James; Inoue Yusuke; Yoon J Cliff; Puigserver Pere; Fan Melina; Gonzalez Frank J; Spiegelman Bruce M
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4012-7.
2003: Puigserver Pere; Spiegelman Bruce M
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.
Endocrine reviews 2003;24(1):78-90.
2003: Girnun Geoffrey D; Spiegelman Bruce M
PPARgamma ligands: taking Ppart in chemoprevention.
Gastroenterology 2003;124(2):564-7.
2003: Tritos Nicholas A; Mastaitis Jason W; Kokkotou Efi G; Puigserver Pere; Spiegelman Bruce M; Maratos-Flier Eleftheria
Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain.
Brain research 2003;961(2):255-60.
2002: Mueller Elisabetta; Drori Stavit; Aiyer Anita; Yie Junming; Sarraf Pasha; Chen Hong; Hauser Stefanie; Rosen Evan D; Ge Kai; Roeder Robert G; Spiegelman Bruce M
Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms.
The Journal of biological chemistry 2002;277(44):41925-30.
2002: Girnun Geoffrey D; Smith Wendy M; Drori Stavit; Sarraf Pasha; Mueller Elisabetta; Eng Charis; Nambiar Prashant; Rosenberg Daniel W; Bronson Roderick T; Edelmann Winfried; Kucherlapati Raju; Gonzalez Frank J; Spiegelman Bruce M
APC-dependent suppression of colon carcinogenesis by PPARgamma.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13771-6.
2002: Kulke Matthew H; Demetri George D; Sharpless Norman E; Ryan David P; Shivdasani Ramesh; Clark Jeffrey S; Spiegelman Bruce M; Kim Haesook; Mayer Robert J; Fuchs Charles S
A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer.
Cancer journal (Sudbury, Mass.) 2002;8(5):395-9.
2002: Lin Jiandie; Wu Hai; Tarr Paul T; Zhang Chen-Yu; Wu Zhidan; Boss Olivier; Michael Laura F; Puigserver Pere; Isotani Eiji; Olson Eric N; Lowell Bradford B; Bassel-Duby Rhonda; Spiegelman Bruce M
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.
Nature 2002;418(6899):797-801.
2002: Ge Kai; Guermah Mohamed; Yuan Chao-Xing; Ito Mitsuhiro; Wallberg Annika E; Spiegelman Bruce M; Roeder Robert G
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.
Nature 2002;417(6888):563-7.
2002: Spiegelman Bruce
The perils of putting career before all else.
Nature 2002;416(6879):365.
2002: Rosen Evan D; Hsu Chung-Hsin; Wang Xinzhong; Sakai Shuichi; Freeman Mason W; Gonzalez Frank J; Spiegelman Bruce M
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.
Genes & development 2002;16(1):22-6.
2002: Lin Jiandie; Puigserver Pere; Donovan Jerry; Tarr Paul; Spiegelman Bruce M
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.
The Journal of biological chemistry 2002;277(3):1645-8.
2001: Puigserver P; Rhee J; Lin J; Wu Z; Yoon J C; Zhang C Y; Krauss S; Mootha V K; Lowell B B; Spiegelman B M
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.
Molecular cell 2001;8(5):971-82.
2001: Tsukiyama-Kohara K; Poulin F; Kohara M; DeMaria C T; Cheng A; Wu Z; Gingras A C; Katsume A; Elchebly M; Spiegelman B M; Harper M E; Tremblay M L; Sonenberg N
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.
Nature medicine 2001;7(10):1128-32.
2001: Rosen E D; Spiegelman B M
PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth.
The Journal of biological chemistry 2001;276(41):37731-4.
2001: Herzig S; Long F; Jhala U S; Hedrick S; Quinn R; Bauer A; Rudolph D; Schutz G; Yoon C; Puigserver P; Spiegelman B; Montminy M
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.
Nature 2001;413(6852):179-83.
2001: Yoon J C; Puigserver P; Chen G; Donovan J; Wu Z; Rhee J; Adelmant G; Stafford J; Kahn C R; Granner D K; Newgard C B; Spiegelman B M
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
Nature 2001;413(6852):131-8.
2001: Michael L F; Wu Z; Cheatham R B; Puigserver P; Adelmant G; Lehman J J; Kelly D P; Spiegelman B M
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3820-5.
2001: Spiegelman B M; Flier J S
Obesity and the regulation of energy balance.
Cell 2001;104(4):531-43.
2001: Moore K J; Rosen E D; Fitzgerald M L; Randow F; Andersson L P; Altshuler D; Milstone D S; Mortensen R M; Spiegelman B M; Freeman M W
The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.
Nature medicine 2001;7(1):41-7.
2000: Spiegelman B M; Puigserver P; Wu Z
Regulation of adipogenesis and energy balance by PPARgamma and PGC-1.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 4():S8-10.
2000: Mueller E; Smith M; Sarraf P; Kroll T; Aiyer A; Kaufman D S; Oh W; Demetri G; Figg W D; Zhou X P; Eng C; Spiegelman B M; Kantoff P W
Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10990-5.
2000: Rosen E D; Spiegelman B M
Peroxisome proliferator-activated receptor gamma ligands and atherosclerosis: ending the heartache.
The Journal of clinical investigation 2000;106(5):629-31.
2000: Monsalve M; Wu Z; Adelmant G; Puigserver P; Fan M; Spiegelman B M
Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.
Molecular cell 2000;6(2):307-16.
2000: Kroll T G; Sarraf P; Pecciarini L; Chen C J; Mueller E; Spiegelman B M; Fletcher J A
PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]
Science (New York, N.Y.) 2000;289(5483):1357-60.
2000: Yoon J C; Chickering T W; Rosen E D; Dussault B; Qin Y; Soukas A; Friedman J M; Holmes W E; Spiegelman B M
Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.
Molecular and cellular biology 2000;20(14):5343-9.
2000: Rosen E D; Walkey C J; Puigserver P; Spiegelman B M
Transcriptional regulation of adipogenesis.
Genes & development 2000;14(11):1293-307.
2000: Hauser S; Adelmant G; Sarraf P; Wright H M; Mueller E; Spiegelman B M
Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation.
The Journal of biological chemistry 2000;275(24):18527-33.
2000: Tcherepanova I; Puigserver P; Norris J D; Spiegelman B M; McDonnell D P
Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1.
The Journal of biological chemistry 2000;275(21):16302-8.
2000: Lowell B B; Spiegelman B M
Towards a molecular understanding of adaptive thermogenesis.
Nature 2000;404(6778):652-60.
2000: Wright H M; Clish C B; Mikami T; Hauser S; Yanagi K; Hiramatsu R; Serhan C N; Spiegelman B M
A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation.
The Journal of biological chemistry 2000;275(3):1873-7.
2000: Rosen E D; Spiegelman B M
Molecular regulation of adipogenesis.
Annual review of cell and developmental biology 2000;16():145-71.
1999: Wu Z; Puigserver P; Spiegelman B M
Transcriptional activation of adipogenesis.
Current opinion in cell biology 1999;11(6):689-94.
1999: Puigserver P; Adelmant G; Wu Z; Fan M; Xu J; O'Malley B; Spiegelman B M
Activation of PPARgamma coactivator-1 through transcription factor docking.
Science (New York, N.Y.) 1999;286(5443):1368-71.
1999: Rosen E D; Sarraf P; Troy A E; Bradwin G; Moore K; Milstone D S; Spiegelman B M; Mortensen R M
PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.
Molecular cell 1999;4(4):611-7.
1999: Devchand P R; Hihi A K; Perroud M; Schleuning W D; Spiegelman B M; Wahli W
Chemical probes that differentially modulate peroxisome proliferator-activated receptor alpha and BLTR, nuclear and cell surface receptors for leukotriene B(4).
The Journal of biological chemistry 1999;274(33):23341-8.
1999: Fajas L; Schoonjans K; Gelman L; Kim J B; Najib J; Martin G; Fruchart J C; Briggs M; Spiegelman B M; Auwerx J
Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism.
Molecular and cellular biology 1999;19(8):5495-503.
1999: Wu Z; Puigserver P; Andersson U; Zhang C; Adelmant G; Mootha V; Troy A; Cinti S; Lowell B; Scarpulla R C; Spiegelman B M
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
Cell 1999;98(1):115-24.
1999: Tabor D E; Kim J B; Spiegelman B M; Edwards P A
Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2.
The Journal of biological chemistry 1999;274(29):20603-10.
1999: Castillo G; Brun R P; Rosenfield J K; Hauser S; Park C W; Troy A E; Wright M E; Spiegelman B M
An adipogenic cofactor bound by the differentiation domain of PPARgamma.
The EMBO journal 1999;18(13):3676-87.
1999: Sarraf P; Mueller E; Smith W M; Wright H M; Kum J B; Aaltonen L A; de la Chapelle A; Spiegelman B M; Eng C
Loss-of-function mutations in PPAR gamma associated with human colon cancer.
Molecular cell 1999;3(6):799-804.
1999: Devine J H; Eubank D W; Clouthier D E; Tontonoz P; Spiegelman B M; Hammer R E; Beale E G
Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo.
The Journal of biological chemistry 1999;274(19):13604-12.
1999: Demetri G D; Fletcher C D; Mueller E; Sarraf P; Naujoks R; Campbell N; Spiegelman B M; Singer S
Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3951-6.
1999: King F J; Hu E; Harris D F; Sarraf P; Spiegelman B M; Roberts T M
DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines.
Molecular and cellular biology 1999;19(3):2330-7.
1999: Wu Z; Rosen E D; Brun R; Hauser S; Adelmant G; Troy A E; McKeon C; Darlington G J; Spiegelman B M
Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.
Molecular cell 1999;3(2):151-8.
1998: Ho I C; Kim J H; Rooney J W; Spiegelman B M; Glimcher L H
A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15537-41.
1998: Sakaue H; Ogawa W; Matsumoto M; Kuroda S; Takata M; Sugimoto T; Spiegelman B M; Kasuga M
Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase.
The Journal of biological chemistry 1998;273(44):28945-52.
1998: Sarraf P; Mueller E; Jones D; King F J; DeAngelo D J; Partridge J B; Holden S A; Chen L B; Singer S; Fletcher C; Spiegelman B M
Differentiation and reversal of malignant changes in colon cancer through PPARgamma.
Nature medicine 1998;4(9):1046-52.
1998: Tabor D E; Kim J B; Spiegelman B M; Edwards P A
Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1.
The Journal of biological chemistry 1998;273(34):22052-8.
1998: Peraldi P; Spiegelman B
TNF-alpha and insulin resistance: summary and future prospects.
Molecular and cellular biochemistry 1998;182(1-2):169-75.
1998: Serova L I; Saez E; Spiegelman B M; Sabban E L
c-Fos deficiency inhibits induction of mRNA for some, but not all, neurotransmitter biosynthetic enzymes by immobilization stress.
Journal of neurochemistry 1998;70(5):1935-40.
1998: Spiegelman B M
PPARgamma in monocytes: less pain, any gain?
Cell 1998;93(2):153-5.
1998: Spiegelman B M
PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
Diabetes 1998;47(4):507-14.
1998: Kim J B; Wright H M; Wright M; Spiegelman B M
ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4333-7.
1998: Puigserver P; Wu Z; Park C W; Graves R; Wright M; Spiegelman B M
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Cell 1998;92(6):829-39.
1998: Mueller E; Sarraf P; Tontonoz P; Evans R M; Martin K J; Zhang M; Fletcher C; Singer S; Spiegelman B M
Terminal differentiation of human breast cancer through PPAR gamma.
Molecular cell 1998;1(3):465-70.
1998: Kim J B; Sarraf P; Wright M; Yao K M; Mueller E; Solanes G; Lowell B B; Spiegelman B M
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.
The Journal of clinical investigation 1998;101(1):1-9.
1997: Peraldi P; Spiegelman B M
Studies of the mechanism of inhibition of insulin signaling by tumor necrosis factor-alpha.
The Journal of endocrinology 1997;155(2):219-20.
1997: Brun R P; Spiegelman B M
PPAR gamma and the molecular control of adipogenesis.
The Journal of endocrinology 1997;155(2):217-8.
1997: Spiegelman B M
Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity.
European journal of medical research 1997;2(11):457-64.
1997: Peraldi P; Xu M; Spiegelman B M
Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.
The Journal of clinical investigation 1997;100(7):1863-9.
1997: Rutberg S E; Saez E; Lo S; Jang S I; Markova N; Spiegelman B M; Yuspa S H
Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters.
Oncogene 1997;15(11):1337-46.
1997: Altiok S; Xu M; Spiegelman B M
PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.
Genes & development 1997;11(15):1987-98.
1997: Brun R P; Kim J B; Hu E; Spiegelman B M
Peroxisome proliferator-activated receptor gamma and the control of adipogenesis.
Current opinion in lipidology 1997;8(4):212-8.
1997: Barlow C; Schroeder M; Lekstrom-Himes J; Kylefjord H; Deng C X; Wynshaw-Boris A; Spiegelman B M; Xanthopoulos K G
Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments.
Nucleic acids research 1997;25(12):2543-5.
1997: Ericsson J; Jackson S M; Kim J B; Spiegelman B M; Edwards P A
Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene.
The Journal of biological chemistry 1997;272(11):7298-305.
1997: Hotamisligil G S; Arner P; Atkinson R L; Spiegelman B M
Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance.
Diabetes 1997;46(3):451-5.
1997: Spiegelman B M; Hu E; Kim J B; Brun R
PPAR gamma and the control of adipogenesis.
Biochimie 1997;79(2-3):111-2.
1997: Hollenberg A N; Susulic V S; Madura J P; Zhang B; Moller D E; Tontonoz P; Sarraf P; Spiegelman B M; Lowell B B
Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter.
The Journal of biological chemistry 1997;272(8):5283-90.
1997: Soloveva V; Graves R A; Rasenick M M; Spiegelman B M; Ross S R
Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity.
Molecular endocrinology (Baltimore, Md.) 1997;11(1):27-38.
1997: Tontonoz P; Singer S; Forman B M; Sarraf P; Fletcher J A; Fletcher C D; Brun R P; Mueller E; Altiok S; Oppenheim H; Evans R M; Spiegelman B M
Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):237-41.
1997: Peraldi P; Spiegelman B M
[TNF-alpha: molecular tie between obesity and insulin resistance]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1997;():149-59.
1997: Hu E; Spiegelman B M
Identification of novel genes involved in adipose differentiation by differential display.
Methods in molecular biology (Clifton, N.J.) 1997;85():195-204.
1996: Hu E; Kim J B; Sarraf P; Spiegelman B M
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma.
Science (New York, N.Y.) 1996;274(5295):2100-3.
1996: Brun R P; Kim J B; Hu E; Altiok S; Spiegelman B M
Adipocyte differentiation: a transcriptional regulatory cascade.
Current opinion in cell biology 1996;8(6):826-32.
1996: Choy L N; Spiegelman B M
Regulation of alternative pathway activation and C3a production by adipose cells.
Obesity research 1996;4(6):521-32.
1996: Zhang B; Berger J; Hu E; Szalkowski D; White-Carrington S; Spiegelman B M; Moller D E
Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha.
Molecular endocrinology (Baltimore, Md.) 1996;10(11):1457-66.
1996: Hotamisligil G S; Johnson R S; Distel R J; Ellis R; Papaioannou V E; Spiegelman B M
Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.
Science (New York, N.Y.) 1996;274(5291):1377-9.
1996: Spiegelman B M; Flier J S
Adipogenesis and obesity: rounding out the big picture.
Cell 1996;87(3):377-89.
1996: Rutberg S E; Saez E; Glick A; Dlugosz A A; Spiegelman B M; Yuspa S H
Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins.
Oncogene 1996;13(1):167-76.
1996: Watanabe Y; Johnson R S; Butler L S; Binder D K; Spiegelman B M; Papaioannou V E; McNamara J O
Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(12):3827-36.
1996: Peraldi P; Hotamisligil G S; Buurman W A; White M F; Spiegelman B M
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase.
The Journal of biological chemistry 1996;271(22):13018-22.
1996: Kim J B; Spiegelman B M
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.
Genes & development 1996;10(9):1096-107.
1996: Hu E; Liang P; Spiegelman B M
AdipoQ is a novel adipose-specific gene dysregulated in obesity.
The Journal of biological chemistry 1996;271(18):10697-703.
1996: Honrado G I; Johnson R S; Golombek D A; Spiegelman B M; Papaioannou V E; Ralph M R
The circadian system of c-fos deficient mice.
Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 1996;178(4):563-70.
1996: Brun R P; Tontonoz P; Forman B M; Ellis R; Chen J; Evans R M; Spiegelman B M
Differential activation of adipogenesis by multiple PPAR isoforms.
Genes & development 1996;10(8):974-84.
1996: Hotamisligil G S; Peraldi P; Budavari A; Ellis R; White M F; Spiegelman B M
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.
Science (New York, N.Y.) 1996;271(5249):665-8.
1995: Forman B M; Tontonoz P; Chen J; Brun R P; Spiegelman B M; Evans R M
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.
Cell 1995;83(5):803-12.
1995: Saez E; Oppenheim H; Smoluk J; Andersen J W; Van Etten R A; Spiegelman B M
c-fos is not essential for v-abl-induced lymphomagenesis.
Cancer research 1995;55(24):6196-9.
1995: Tontonoz P; Hu E; Spiegelman B M
Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma.
Current opinion in genetics & development 1995;5(5):571-6.
1995: Hu E; Tontonoz P; Spiegelman B M
Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9856-60.
1995: Saez E; Rutberg S E; Mueller E; Oppenheim H; Smoluk J; Yuspa S H; Spiegelman B M
c-fos is required for malignant progression of skin tumors.
Cell 1995;82(5):721-32.
1995: Ross S R; Graves R A; Choy L; Soleveva V; Spiegelman B M
Transgenic mouse models of disease: altering adipose tissue function in vivo.
Annals of the New York Academy of Sciences 1995;758():297-313.
1995: Kim J B; Spotts G D; Halvorsen Y D; Shih H M; Ellenberger T; Towle H C; Spiegelman B M
Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain.
Molecular and cellular biology 1995;15(5):2582-8.
1995: Hotamisligil G S; Arner P; Caro J F; Atkinson R L; Spiegelman B M
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
The Journal of clinical investigation 1995;95(5):2409-15.
1995: Claffey K P; Senger D R; Spiegelman B M
Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF.
Biochimica et biophysica acta 1995;1246(1):1-9.
1995: Tontonoz P; Hu E; Devine J; Beale E G; Spiegelman B M
PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene.
Molecular and cellular biology 1995;15(1):351-7.
1994: Tontonoz P; Hu E; Spiegelman B M
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.
Cell 1994;79(7):1147-56.
1994: Tontonoz P; Graves R A; Budavari A I; Erdjument-Bromage H; Lui M; Hu E; Tempst P; Spiegelman B M
Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha.
Nucleic acids research 1994;22(25):5628-34.
1994: Platt K A; Claffey K P; Wilkison W O; Spiegelman B M; Ross S R
Independent regulation of adipose tissue-specificity and obesity response of the adipsin promoter in transgenic mice.
The Journal of biological chemistry 1994;269(46):28558-62.
1994: Hotamisligil G S; Spiegelman B M
Tumor necrosis factor alpha: a key component of the obesity-diabetes link.
Diabetes 1994;43(11):1271-8.
1994: Hotamisligil G S; Budavari A; Murray D; Spiegelman B M
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
The Journal of clinical investigation 1994;94(4):1543-9.
1994: Hu E; Mueller E; Oliviero S; Papaioannou V E; Johnson R; Spiegelman B M
Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes.
The EMBO journal 1994;13(13):3094-103.
1994: Paylor R; Johnson R S; Papaioannou V; Spiegelman B M; Wehner J M
Behavioral assessment of c-fos mutant mice.
Brain research 1994;651(1-2):275-82.
1994: Hotamisligil G S; Murray D L; Choy L N; Spiegelman B M
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4854-8.
1994: Tontonoz P; Hu E; Graves R A; Budavari A I; Spiegelman B M
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
Genes & development 1994;8(10):1224-34.
1994: Jain J; Nalefski E A; McCaffrey P G; Johnson R S; Spiegelman B M; Papaioannou V; Rao A
Normal peripheral T-cell function in c-Fos-deficient mice.
Molecular and cellular biology 1994;14(3):1566-74.
1994: Hofmann C; Lorenz K; Braithwaite S S; Colca J R; Palazuk B J; Hotamisligil G S; Spiegelman B M
Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.
Endocrinology 1994;134(1):264-70.
1994: Klaus S; Choy L; Champigny O; Cassard-Doulcier A M; Ross S; Spiegelman B; Ricquier D
Characterization of the novel brown adipocyte cell line HIB 1B. Adrenergic pathways involved in regulation of uncoupling protein gene expression.
Journal of cell science 1994;107 ( Pt 1)():313-9.
1993: Halvorsen Y D; Bursell S E; Wilkison W O; Clermont A C; Brittis M; McGovern T J; Spiegelman B M
Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes.
The Journal of clinical investigation 1993;92(6):2872-6.
1993: Tontonoz P; Kim J B; Graves R A; Spiegelman B M
ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.
Molecular and cellular biology 1993;13(8):4753-9.
1993: Ross S R; Graves R A; Spiegelman B M
Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity.
Genes & development 1993;7(7B):1318-24.
1993: Johnson R S; van Lingen B; Papaioannou V E; Spiegelman B M
A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.
Genes & development 1993;7(7B):1309-17.
1993: Pascual M; Catana E; White T; Spiegelman B M; Schifferli J A
Inhibition of complement alternative pathway in mice with Fab antibody to recombinant adipsin/factor D.
European journal of immunology 1993;23(6):1389-92.
1993: Spiegelman B M; Hotamisligil G S
Through thick and thin: wasting, obesity, and TNF alpha.
Cell 1993;73(4):625-7.
1993: Spiegelman B M; Choy L; Hotamisligil G S; Graves R A; Tontonoz P
Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.
The Journal of biological chemistry 1993;268(10):6823-6.
1993: Wilkison W O; Spiegelman B M
Biosynthesis of the vasoactive lipid monobutyrin. Central role of diacylglycerol.
The Journal of biological chemistry 1993;268(4):2844-9.
1993: Hotamisligil G S; Shargill N S; Spiegelman B M
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
Science (New York, N.Y.) 1993;259(5091):87-91.
1992: Johnson R S; Spiegelman B M; Papaioannou V
Pleiotropic effects of a null mutation in the c-fos proto-oncogene.
Cell 1992;71(4):577-86.
1992: Field S J; Johnson R S; Mortensen R M; Papaioannou V E; Spiegelman B M; Greenberg M E
Growth and differentiation of embryonic stem cells that lack an intact c-fos gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9306-10.
1992: Oliviero S; Robinson G S; Struhl K; Spiegelman B M
Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation.
Genes & development 1992;6(9):1799-809.
1992: Claffey K P; Wilkison W O; Spiegelman B M
Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.
The Journal of biological chemistry 1992;267(23):16317-22.
1992: Ross S R; Choy L; Graves R A; Fox N; Solevjeva V; Klaus S; Ricquier D; Spiegelman B M
Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7561-5.
1992: Graves R A; Tontonoz P; Platt K A; Ross S R; Spiegelman B M
Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression.
Journal of cellular biochemistry 1992;49(3):219-24.
1992: Graves R A; Tontonoz P; Spiegelman B M
Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.
Molecular and cellular biology 1992;12(7):3313.
1992: Choy L N; Rosen B S; Spiegelman B M
Adipsin and an endogenous pathway of complement from adipose cells.
The Journal of biological chemistry 1992;267(18):12736-41.
1992: White R T; Damm D; Hancock N; Rosen B S; Lowell B B; Usher P; Flier J S; Spiegelman B M
Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.
The Journal of biological chemistry 1992;267(13):9210-3.
1992: Graves R A; Tontonoz P; Spiegelman B M
Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.
Molecular and cellular biology 1992;12(3):1202-8.
1992: Distel R J; Robinson G S; Spiegelman B M
Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms.
The Journal of biological chemistry 1992;267(9):5937-41.
1991: Wilkison W O; Choy L; Spiegelman B M
Biosynthetic regulation of monobutyrin, an adipocyte-secreted lipid with angiogenic activity.
The Journal of biological chemistry 1991;266(25):16886-91.
1991: Graves R A; Tontonoz P; Ross S R; Spiegelman B M
Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor.
Genes & development 1991;5(3):428-37.
1990: Ross S R; Graves R A; Greenstein A; Platt K A; Shyu H L; Mellovitz B; Spiegelman B M
A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9590-4.
1990: Herrera R; Agarwal S; Walton K; Satterberg B; Distel R J; Goodman R; Spiegelman B M; Roberts T M
A direct role for c-fos in AP-1-dependent gene transcription.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(10):483-90.
1990: Allegretto E A; Smeal T; Angel P; Spiegelman B M; Karin M
DNA-binding activity of Jun is increased through its interaction with Fos.
Journal of cellular biochemistry 1990;42(4):193-206.
1990: Dobson D E; Kambe A; Block E; Dion T; Lu H; Castellot J J; Spiegelman B M
1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes.
Cell 1990;61(2):223-30.
1990: Lowell B B; Napolitano A; Usher P; Dulloo A G; Rosen B S; Spiegelman B M; Flier J S
Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine.
Endocrinology 1990;126(3):1514-20.
1990: Wilkison W O; Min H Y; Claffey K P; Satterberg B L; Spiegelman B M
Control of the adipsin gene in adipocyte differentiation. Identification of distinct nuclear factors binding to single- and double-stranded DNA.
The Journal of biological chemistry 1990;265(1):477-82.
1990: Distel R J; Spiegelman B M
Protooncogene c-fos as a transcription factor.
Advances in cancer research 1990;55():37-55.
1989: Herrera R; Ro H S; Robinson G S; Xanthopoulos K G; Spiegelman B M
A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation.
Molecular and cellular biology 1989;9(12):5331-9.
1989: Platt K A; Min H Y; Ross S R; Spiegelman B M
Obesity-linked regulation of the adipsin gene promoter in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7490-4.
1989: Kitagawa K; Rosen B S; Spiegelman B M; Lienhard G E; Tanner L I
Insulin stimulates the acute release of adipsin from 3T3-L1 adipocytes.
Biochimica et biophysica acta 1989;1014(1):83-9.
1989: Johnson R S; Sheng M; Greenberg M E; Kolodner R D; Papaioannou V E; Spiegelman B M
Targeting of nonexpressed genes in embryonic stem cells via homologous recombination.
Science (New York, N.Y.) 1989;245(4923):1234-6.
1989: Rosen B S; Cook K S; Yaglom J; Groves D L; Volanakis J E; Damm D; White T; Spiegelman B M
Adipsin and complement factor D activity: an immune-related defect in obesity.
Science (New York, N.Y.) 1989;244(4911):1483-7.
1989: Spiegelman B M; Lowell B; Napolitano A; Dubuc P; Barton D; Francke U; Groves D L; Cook K S; Flier J S
Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice.
The Journal of biological chemistry 1989;264(3):1811-5.
1989: Flier J S; Lowell B; Napolitano A; Usher P; Rosen B; Cook K S; Spiegelman B
Adipsin: regulation and dysregulation in obesity and other metabolic states.
Recent progress in hormone research 1989;45():567-80; discussion 580-1.
1988: Spiegelman B M; Distel R J; Ro H S; Rosen B S; Satterberg B
fos protooncogene and the regulation of gene expression in adipocyte differentiation.
The Journal of cell biology 1988;107(3):829-32.
1988: Spiegelman B M
Regulation of gene expression in the adipocyte: implications for obesity and proto-oncogene function.
Trends in genetics : TIG 1988;4(7):203-7.
1988: Cherington V; Brown M; Paucha E; St Louis J; Spiegelman B M; Roberts T M
Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation.
Molecular and cellular biology 1988;8(3):1380-4.
1988: Rauscher F J; Sambucetti L C; Curran T; Distel R J; Spiegelman B M
Common DNA binding site for Fos protein complexes and transcription factor AP-1.
Cell 1988;52(3):471-80.
1988: Distel R J; Spiegelman B M
Involvement of fos as a trans-acting factor in adipogenic gene expression.
Progress in clinical and biological research 1988;284():187-209.
1987: Flier J S; Cook K S; Usher P; Spiegelman B M
Severely impaired adipsin expression in genetic and acquired obesity.
Science (New York, N.Y.) 1987;237(4813):405-8.
1987: Cook K S; Min H Y; Johnson D; Chaplinsky R J; Flier J S; Hunt C R; Spiegelman B M
Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve.
Science (New York, N.Y.) 1987;237(4813):402-5.
1987: Distel R J; Ro H S; Rosen B S; Groves D L; Spiegelman B M
Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos.
Cell 1987;49(6):835-44.
1987: Dobson D E; Groves D L; Spiegelman B M
Nucleotide sequence and hormonal regulation of mouse glycerophosphate dehydrogenase mRNA during adipocyte and muscle cell differentiation.
The Journal of biological chemistry 1987;262(4):1804-9.
1986: Min H Y; Spiegelman B M
Adipsin, the adipocyte serine protease: gene structure and control of expression by tumor necrosis factor.
Nucleic acids research 1986;14(22):8879-92.
1986: Hunt C R; Ro J H; Dobson D E; Min H Y; Spiegelman B M
Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):3786-90.
1986: Cherington V; Morgan B; Spiegelman B M; Roberts T M
Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(12):4307-11.
1986: Castellot J J; Kambe A M; Dobson D E; Spiegelman B M
Heparin potentiation of 3T3-adipocyte stimulated angiogenesis: mechanisms of action on endothelial cells.
Journal of cellular physiology 1986;127(2):323-9.
1986: Spiegelman B M; Cook K S; Hunt C R
Regulation of gene expression during the differentiation of 3T3-adipocytes.
Progress in clinical and biological research 1986;226():445-54.
1985: Cook K S; Groves D L; Min H Y; Spiegelman B M
A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(19):6480-4.
1985: Cook K S; Hunt C R; Spiegelman B M
Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control.
The Journal of cell biology 1985;100(2):514-20.
1983: Spiegelman B M; Ginty C A
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes.
Cell 1983;35(3 Pt 2):657-66.
1983: Spiegelman B M; Frank M; Green H
Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development.
The Journal of biological chemistry 1983;258(16):10083-9.
1982: Castellot J J; Karnovsky M J; Spiegelman B M
Differentiation-dependent stimulation of neovascularization and endothelial cell chemotaxis by 3T3 adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(18):5597-601.
1982: Spiegelman B M; Farmer S R
Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 adipocytes.
Cell 1982;29(1):53-60.
1981: Spiegelman B M; Green H
Cyclic AMP-mediated control of lipogenic enzyme synthesis during adipose differentiation of 3T3 cells.
Cell 1981;24(2):503-10.
1980: Castellot J J; Karnovsky M J; Spiegelman B M
Potent stimulation of vascular endothelial cell growth by differentiated 3T3 adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(10):6007-11.
1980: Spiegelman B M; Green H
Control of specific protein biosynthesis during the adipose conversion of 3T3 cells.
The Journal of biological chemistry 1980;255(18):8811-18.
1979: Cleveland D W; Spiegelman B M; Kirschner M W
Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins.
The Journal of biological chemistry 1979;254(24):12670-8.

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