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Bruce Spiegelman

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Francisca Vazquez; Hans R Widlund; Bruce M Spiegelman; Kavita Bhalla; Helen Chim; Clary B Clish; Geoffrey D Girnun; Scott R Granter; Ji-Hong Lim; Kerry Pierce; Pere Puigserver
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.
Jun Wu; Paul Cohen; Bruce M Spiegelman
Adaptive thermogenesis in adipocytes: is beige the new brown?
Jorge L Ruas; James P White; Jun Wu; Zhen Yan; Kevin T Brannan; Jennifer L Estall; Nicholas P Greene; Brooke C Harrison; Brian Irving; Sandra Kleiner; Ian R Lanza; Leslie A Leinwand; K Sreekumaran Nair; Mitsuharu Okutsu; Rajesh R Rao; Kyle A Rasbach; Bruce M Spiegelman
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.

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2013: Francisca Vazquez; Hans R Widlund; Bruce M Spiegelman; Kavita Bhalla; Helen Chim; Clary B Clish; Geoffrey D Girnun; Scott R Granter; Ji-Hong Lim; Kerry Pierce; Pere Puigserver
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.
Cancer cell 2013;23(3):287-301.
2013: Jun Wu; Paul Cohen; Bruce M Spiegelman
Adaptive thermogenesis in adipocytes: is beige the new brown?
Genes & development 2013;27(3):234-50.
2012: Jorge L Ruas; James P White; Jun Wu; Zhen Yan; Kevin T Brannan; Jennifer L Estall; Nicholas P Greene; Brooke C Harrison; Brian Irving; Sandra Kleiner; Ian R Lanza; Leslie A Leinwand; K Sreekumaran Nair; Mitsuharu Okutsu; Rajesh R Rao; Kyle A Rasbach; Bruce M Spiegelman
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy.
Cell 2012;151(6):1319-31.
2012: Li Ye; Jun Wu; Alexander S Banks; Pontus Boström; David E Clapham; Paul Cohen; Patrick R Griffin; Rana K Gupta; Theodore M Kamenecka; Melin J Khandekar; Sandra Kleiner; Dina Laznik; Wolfgang Liedtke; Rina J Mepani; Vamsi K Mootha; Pere Puigserver; Rajan Sah; Xinyi Song; Bruce M Spiegelman
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.
Cell 2012;151(1):96-110.
2012: Jun Wu; Li Ye; Hua Tu; Wouter D van Marken Lichtenbelt; Kirsi A Virtanen; Pontus Boström; Jang Hyun Choi; Sven Enerbäck; An-Hoa Giang; Joris Hoeks; Kexin Huang; Melin Khandekar; Pirjo Nuutila; Gert Schaart; Patrick Schrauwen; Lauren M Sparks; Bruce M Spiegelman
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.
Cell 2012;150(2):366-76.
2012: Sandra Kleiner; Dina Laznik; Rina J Mepani; Gerald I Shulman; Diti Chatterjee Bhowmick; Jennifer L Estall; François R Jornayvaz; Michael J Jurczak; Li Ye; Bruce M Spiegelman
Development of insulin resistance in mice lacking PGC-1α in adipose tissues.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(24):9635-40.
2012: Sandrine Da Cruz; Sandra K Lee; Concepcion Lillo; Vanda S Lopes; Martin Marsala; Melissa McAlonis-Downes; Anne N Murphy; Philippe A Parone; Susanna Petrosyan; Bruce M Spiegelman; Anne P Vetto; David S Williams; Don W Cleveland
Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS.
Cell metabolism 2012;15(5):778-86.
2012: Rana K Gupta; Melin J Khandekar; Sandra Kleiner; James C Lo; Rina J Mepani; Diti Chatterjee Bhowmick; Saverio Cinti; Paul Cohen; Andrea Frontini; Li Ye; Bruce M Spiegelman
Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells.
Cell metabolism 2012;15(2):230-9.
2012: Ffolliott M Fisher; Jeffrey S Flier; Elliott C Fox; Alexei Kharitonenkov; Sandra Kleiner; Eleftheria Maratos-Flier; Rina J Mepani; Francisco Verdeguer; Jun Wu; Nicholas Douris; Bruce M Spiegelman
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.
Genes & development 2012;26(3):271-81.
2012: Pontus Boström; Jang Hyun Choi; Saverio Cinti; Steven P Gygi; Kurt Højlund; Mark P Jedrychowski; Shingo Kajimura; Anisha Korde; James C Lo; Jonathan Z Long; Kyle A Rasbach; Hua Tu; Birgitte F Vind; Jun Wu; Li Ye; Maria Cristina Zingaretti; Elisabeth Almer Boström; Bruce M Spiegelman
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
Nature 2012;481(7382):463-8.
2011: Srikripa Devarakonda; Patrick R Griffin; Kushol Gupta; John F Hunt; Michael J Chalmers; Gregory D Van Duyne; Bruce M Spiegelman
Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(46):18678-83.
2011: Jang Hyun Choi; Alexander S Banks; John B Bruning; Scott A Busby; Michael D Cameron; Michael J Chalmers; Yuanjun He; Michael J Jurczak; Theodore M Kamenecka; Naresh Kumar; Dana S Kuruvilla; Dina Laznik; David P Marciano; Stephan C Schürer; Youseung Shin; Gerald I Shulman; Bruce M Spiegelman; Dušica Vidović; Patrick R Griffin
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.
Nature 2011;477(7365):477-81.
2011: Ffolliott M Fisher; Jeffrey S Flier; Alexei Kharitonenkov; Andrew C Adams; Patrick J Antonellis; Holly A Bina; Jennifer L Estall; Bruce M Spiegelman; Eleftheria Maratos-Flier
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.
Endocrinology 2011;152(8):2996-3004.
2011: Yaniv Lustig; Jesper V Olsen; Hiraku Ono; Jorge L Ruas; Jang Hyun Choi; Srikripa Devarakonda; Jennifer L Estall; Dina Laznik; James C Lo; Bruce M Spiegelman
Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase.
Genes & development 2011;25(12):1232-44.
2011: Jun Wu; Jorge L Ruas; Jennifer L Estall; Kyle A Rasbach; Jang Hyun Choi; Li Ye; Pontus Boström; Heather M Tyra; Robert W Crawford; Kevin P Campbell; D Thomas Rutkowski; Randal J Kaufman; Bruce M Spiegelman
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex.
Cell metabolism 2011;13(2):160-9.
2011: Patrick Seale; Heather M Conroe; Jennifer Estall; Shingo Kajimura; Andrea Frontini; Jeff Ishibashi; Paul Cohen; Saverio Cinti; Bruce M Spiegelman
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.
The Journal of clinical investigation 2011;121(1):96-105.
2010: Pontus Boström; Nina Mann; Jun Wu; Pablo A Quintero; Eva R Plovie; Daniela Panáková; Rana K Gupta; Chunyang Xiao; Calum A MacRae; Anthony Rosenzweig; Bruce M Spiegelman
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.
Cell 2010;143(7):1072-83.
2010: Jang Hyun Choi; Alexander S Banks; Jennifer L Estall; Shingo Kajimura; Pontus Boström; Dina Laznik; Jorge Ruas; Michael J Chalmers; Theodore M Kamenecka; Matthias Blüher; Patrick R Griffin; Bruce M Spiegelman
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Nature 2010;466(7305):451-6.
2010: Shingo Kajimura; Patrick Seale; Bruce M Spiegelman
Transcriptional control of brown fat development.
Cell metabolism 2010;11(4):257-62.
2010: Rana K Gupta; Zoltan Arany; Patrick Seale; Rina J Mepani; Li Ye; Heather M Conroe; Yang A Roby; Heather Kulaga; Randall R Reed; Bruce M Spiegelman
Transcriptional control of preadipocyte determination by Zfp423.
Nature 2010;464(7288):619-23.
2009: Jennifer L Estall; Jorge Ruas; Cheol Soo Choi; Dina Laznik; Michael Badman; Eleftheria Maratos-Flier; Gerald I Shulman; Bruce M Spiegelman
PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22510-5.
2009: Shingo Kajimura; Patrick Seale; Kazuishi Kubota; Elaine Lunsford; John V Frangioni; Steven P Gygi; Bruce M Spiegelman
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
Nature 2009;460(7259):1154-8.
2009: Jennifer L Estall; Mario Kahn; Marcus P Cooper; Ffolliott Martin Fisher; Michele K Wu; Dina Laznik; Lishu Qu; David E Cohen; Gerald I Shulman; Bruce M Spiegelman
Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.
Diabetes 2009;58(7):1499-508.
2009: Patrick Seale; Shingo Kajimura; Bruce M Spiegelman
Transcriptional control of brown adipocyte development and physiological function--of mice and men.
Genes & development 2009;23(7):788-97.
2008: Marcus P Cooper; Marc Uldry; Shingo Kajimura; Zoltan Arany; Bruce M Spiegelman
Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130.
The Journal of biological chemistry 2008;283(46):31960-7.
2008: Geoffrey D Girnun; Liang Chen; Jessica Silvaggi; Ronny Drapkin; Lucian R Chirieac; Robert F Padera; Rabi Upadhyay; Scott B Vafai; Ralph Weissleder; Umar Mahmood; Elnaz Naseri; Stephanie Buckley; Danan Li; Jeremy Force; Kate McNamara; George Demetri; Bruce M Spiegelman; Kwok-Kin Wong
Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6478-86.
2008: Christopher J Walkey; Bruce M Spiegelman
A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis.
The Journal of biological chemistry 2008;283(36):24290-4.
2008: Patrick Seale; Bryan Bjork; Wenli Yang; Shingo Kajimura; Sherry Chin; Shihuan Kuang; Anthony Scimè; Srikripa Devarakonda; Heather M Conroe; Hediye Erdjument-Bromage; Paul Tempst; Michael A Rudnicki; David Beier; Bruce M Spiegelman
PRDM16 controls a brown fat/skeletal muscle switch.
Nature 2008;454(7207):961-7.
2008: Christoph Handschin; Bruce M Spiegelman
The role of exercise and PGC1alpha in inflammation and chronic disease.
Nature 2008;454(7203):463-9.
2008: Shingo Kajimura; Patrick Seale; Takuya Tomaru; Hediye Erdjument-Bromage; Marcus P Cooper; Jorge Ruas; Sherry Chin; Paul Tempst; Mitchell Lazar; Bruce M Spiegelman
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
Genes & development 2008;22(10):1397-409.
2008: Jennifer A Calvo; Thomas G Daniels; Xiaomei Wang; Angelika Paul; Jiandie Lin; Bruce M Spiegelman; Susan C Stevenson; Shamina M Rangwala
Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake.
Journal of applied physiology (Bethesda, Md. : 1985) 2008;104(5):1304-12.
2008: Zoltan Arany; Bridget K Wagner; Yanhong Ma; Jessica Chinsomboon; Dina Laznik; Bruce M Spiegelman
Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4721-6.
2008: Zoltan Arany; Shi-Yin Foo; Yanhong Ma; Jorge Ruas; Archana Bommi-Reddy; Geoffrey D Girnun; Marcus P Cooper; Dina Laznik; Jessica Chinsomboon; Shamina M Rangwala; Kwan-Hyuck Baek; Anthony Rosenzweig; Bruce M Spiegelman
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.
Nature 2008;451(7181):1008-12.
2008: Peter Tontonoz; Bruce M Spiegelman
Fat and beyond: the diverse biology of PPARgamma.
Annual review of biochemistry 2008;77():289-312.
2007: Christoph Handschin; Cheol Soo Choi; Sherry Chin; Sheene Kim; Dan Kawamori; Amarnath J Kurpad; Nicole Neubauer; Jiang Hu; Vamsi K Mootha; Young-Bum Kim; Rohit N Kulkarni; Gerald I Shulman; Bruce M Spiegelman
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.
The Journal of clinical investigation 2007;117(11):3463-74.
2007: Christoph Handschin; Sherry Chin; Ping Li; Fenfen Liu; Eleftheria Maratos-Flier; Nathan K LeBrasseur; Zhen Yan; Bruce M Spiegelman
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.
The Journal of biological chemistry 2007;282(41):30014-21.
2007: Sibylle Jäger; Christoph Handschin; Julie St-Pierre; Bruce M Spiegelman
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12017-22.
2007: Patrick Seale; Shingo Kajimura; Wenli Yang; Sherry Chin; Lindsay M Rohas; Marc Uldry; Geneviève Tavernier; Dominique Langin; Bruce M Spiegelman
Transcriptional control of brown fat determination by PRDM16.
Cell metabolism 2007;6(1):38-54.
2007: Lindsay M Rohas; Julie St-Pierre; Marc Uldry; Sibylle Jäger; Christoph Handschin; Bruce M Spiegelman
A fundamental system of cellular energy homeostasis regulated by PGC-1alpha.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):7933-8.
2007: Geoffrey D Girnun; Elnaz Naseri; Scott B Vafai; Lishu Qu; Jeffrey D Szwaya; Roderick Bronson; John A Alberta; Bruce M Spiegelman
Synergy between PPARgamma ligands and platinum-based drugs in cancer.
Cancer cell 2007;11(5):395-406.
2007: Christoph Handschin; Yvonne M Kobayashi; Sherry Chin; Patrick Seale; Kevin P Campbell; Bruce M Spiegelman
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.
Genes & development 2007;21(7):770-83.
2007: Bruce M Spiegelman
Transcriptional control of energy homeostasis through the PGC1 coactivators.
Novartis Foundation symposium 2007;286():3-6; discusssion 6-12, 162-3, 196-203.
2007: Bruce M Spiegelman
Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.
Novartis Foundation symposium 2007;287():60-3; discussion 63-9.
2007: Zoltan Arany; Nathan K LeBrasseur; Carl Morris; Eric Smith; Wenli Yang; Yanhong Ma; Sherry Chin; Bruce M Spiegelman
The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle.
Cell metabolism 2007;5(1):35-46.
2006: Evan D Rosen; Bruce M Spiegelman
Adipocytes as regulators of energy balance and glucose homeostasis.
Nature 2006;444(7121):847-53.
2006: Bruce M Spiegelman; Sven Enerbäck
"The adipocyte: a multifunctional cell".
Cell metabolism 2006;4(6):425-7.
2006: Claudia R Vianna; Michael Huntgeburth; Roberto Coppari; Cheol Soo Choi; Jiandie Lin; Stefan Krauss; Giorgio Barbatelli; Iphigenia Tzameli; Young-Bum Kim; Saverio Cinti; Gerald I Shulman; Bruce M Spiegelman; Bradford B Lowell
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
Cell metabolism 2006;4(6):453-64.
2006: Liliane Michalik; Johan Auwerx; Joel P Berger; V Krishna Chatterjee; Christopher K Glass; Frank J Gonzalez; Paul A Grimaldi; Takashi Kadowaki; Mitchell Lazar; Stephen O'Rahilly; Colin N A Palmer; Jorge Plutzky; Janardan K Reddy; Bruce M Spiegelman; Bart Staels; Walter Wahli
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
Pharmacological reviews 2006;58(4):726-41.
2006: Christophe Handschin; Bruce M Spiegelman
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.
Endocrine reviews 2006;27(7):728-35.
2006: Marcus P Cooper; Lishu Qu; Lindsay M Rohas; Jiandie Lin; Wenli Yang; Hediye Erdjument-Bromage; Paul Tempst; Bruce M Spiegelman
Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.
Genes & development 2006;20(21):2996-3009.
2006: Marco Sandri; Jiandie Lin; Christoph Handschin; Wenli Yang; Zoltan Arany; Stewart H Lecker; Alfred L Goldberg; Bruce M Spiegelman
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16260-5.
2006: Julie St-Pierre; Stavit Drori; Marc Uldry; Jessica M Silvaggi; James Rhee; Sibylle Jäger; Christoph Handschin; Kangni Zheng; Jiandie Lin; Wenli Yang; David K Simon; Robert Bachoo; Bruce M Spiegelman
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.
Cell 2006;127(2):397-408.
2006: Zhidan Wu; Xueming Huang; Yajun Feng; Christoph Handschin; Yan Feng; P Scott Gullicksen; Olivia Bare; Mark Labow; Bruce M Spiegelman; Susan C Stevenson
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14379-84.
2006: Zoltan Arany; Mikhail Novikov; Sherry Chin; Yanhong Ma; Anthony Rosenzweig; Bruce M Spiegelman
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):10086-91.
2006: James Rhee; Hongfei Ge; Wenli Yang; Melina Fan; Christoph Handschin; Marcus P Cooper; Jiandie Lin; Cai Li; Bruce M Spiegelman
Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism.
The Journal of biological chemistry 2006;281(21):14683-90.
2006: Marc Uldry; Wenli Yang; Julie St-Pierre; Jiandie Lin; Patrick Seale; Bruce M Spiegelman
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation.
Cell metabolism 2006;3(5):333-41.
2005: Christoph Handschin; Jiandie Lin; James Rhee; Anne-Kathrin Peyer; Sherry Chin; Pei-Hsuan Wu; Urs A Meyer; Bruce M Spiegelman
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.
Cell 2005;122(4):505-15.
2005: Jeong-Ho Hong; Eun Sook Hwang; Michael McManus; Adam Amsterdam; Yu Tian; Ralitsa Kalmukova; Elisabetta Mueller; Thomas Benjamin; Bruce M Spiegelman; Phillip A Sharp; Nancy Hopkins; Michael B Yaffe
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
Science (New York, N.Y.) 2005;309(5737):1074-8.
2005: Jiandie Lin; Christoph Handschin; Bruce M Spiegelman
Metabolic control through the PGC-1 family of transcription coactivators.
Cell metabolism 2005;1(6):361-70.
2005: Gitte Andersen; Lise Wegner; K Yanagisawa; Christian Schack Rose; Jiandie Lin; Charlotte Glümer; Thomas Drivsholm; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Bruce M Spiegelman; Oluf Pedersen
Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.
Journal of medical genetics 2005;42(5):402-7.
2005: Zoltan Arany; Huamei He; Jiandie Lin; Kirsten Hoyer; Christoph Handschin; Okan Toka; Ferhaan Ahmad; Takashi Matsui; Sherry Chin; Pei-Hsuan Wu; Igor I Rybkin; John M Shelton; Monia Manieri; Saverio Cinti; Frederick Schoen; Rhonda Bassel-Duby; Anthony Rosenzweig; Joanne S Ingwall; Bruce M Spiegelman
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.
Cell metabolism 2005;1(4):259-71.
2005: Joseph T Rodgers; Carles Lerin; Wilhelm Haas; Steven P Gygi; Bruce M Spiegelman; Pere Puigserver
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Nature 2005;434(7029):113-8.
2005: Zhu Chen; Javier I Torrens; Ashim Anand; Bruce M Spiegelman; Jeffrey M Friedman
Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms.
Cell metabolism 2005;1(2):93-106.
2005: Stavit Drori; Geoffrey D Girnun; Liqiang Tou; Jeffrey D Szwaya; Elisabetta Mueller; Kai Xia; Xia Kia; Ramesh A Shivdasani; Bruce M Spiegelman
Hic-5 regulates an epithelial program mediated by PPARgamma.
Genes & development 2005;19(3):362-75.
2005: Jiandie Lin; Ruojing Yang; Paul T Tarr; Pei-Hsuan Wu; Christoph Handschin; Siming Li; Wenli Yang; Liming Pei; Marc Uldry; Peter Tontonoz; Christopher B Newgard; Bruce M Spiegelman
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
Cell 2005;120(2):261-73.
2004: Bruce M Spiegelman; Reinhart Heinrich
Biological control through regulated transcriptional coactivators.
Cell 2004;119(2):157-67.
2004: Matthew R Smith; Judith Manola; Donald S Kaufman; Daniel George; William K Oh; Elisabetta Mueller; Susan F Slovin; Bruce M Spiegelman; Eric Small; Philip W Kantoff
Rosiglitazone versus placebo for men with prostate carcinoma and a rising serum prostate-specific antigen level after radical prostatectomy and/or radiation therapy.
Cancer 2004;101(7):1569-74.
2004: Jiandie Lin; Pei-Hsuan Wu; Paul T Tarr; Katrin S Lindenberg; Julie St-Pierre; Chen-Yu zhang; Vamsi K Mootha; Sibylle Jäger; Claudia R Vianna; Richard M Reznick; Libin Cui; Monia Manieri; Mi X Donovan; Zhidan Wu; Marcus P Cooper; Melina C Fan; Lindsay M Rohas; Ann Marie Zavacki; Saverio Cinti; Gerald I Shulman; Bradford B Lowell; Dimitri Krainc; Bruce M Spiegelman
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
Cell 2004;119(1):121-35.
2004: Vamsi K Mootha; Christoph Handschin; Dan Arlow; Xiaohui Xie; Julie St Pierre; Smita Sihag; Wenli Yang; David Altshuler; Pere Puigserver; Nick Patterson; Patricia J Willy; Ira G Schulman; Richard A Heyman; Eric S Lander; Bruce M Spiegelman
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6570-5.
2004: Wenhong Cao; Kiefer W Daniel; jacques robidoux; Pere Puigserver; Alexander Medvedev; Xu Bai; Lisa M Floering; Bruce M Spiegelman; Sheila Collins
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
Molecular and cellular biology 2004;24(7):3057-67.
2004: Melina Fan; James Rhee; Julie St-Pierre; Christoph Handschin; Pere Puigserver; Jiandie Lin; Sibylle Jäeger; Hediye Erdjument-Bromage; Paul Tempst; Bruce M Spiegelman
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.
Genes & development 2004;18(3):278-89.
2003: Annika E Wallberg; Soichiro Yamamura; Sohail Malik; Bruce M Spiegelman; Robert G Roeder
Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.
Molecular cell 2003;12(5):1137-49.
2003: Evan D Rosen; Rohit N Kulkarni; pasha sarraf; Umut Ozcan; Terumasa Okada; Chung-Hsin Hsu; Daniel Eisenman; Mark Magnuson; Frank J Gonzalez; C Ronald Kahn; Bruce M Spiegelman
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.
Molecular and cellular biology 2003;23(20):7222-9.
2003: Jiandie Lin; Paul T Tarr; Ruojing Yang; James Rhee; Pere Puigserver; Christopher B Newgard; Bruce M Spiegelman
PGC-1beta in the regulation of hepatic glucose and energy metabolism.
The Journal of biological chemistry 2003;278(33):30843-8.
2003: Andrew W Norris; Lihong Chen; Simon J Fisher; Ildiko Szanto; Michael Ristow; Alison C Jozsi; Michael F Hirshman; Evan D Rosen; Laurie J Goodyear; Frank J Gonzalez; Bruce M Spiegelman; C Ronald Kahn
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.
The Journal of clinical investigation 2003;112(4):608-18.
2003: Julie St-Pierre; Jiandie Lin; Stefan Krauss; Paul T Tarr; Ruojing Yang; Christopher B Newgard; Bruce M Spiegelman
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells.
The Journal of biological chemistry 2003;278(29):26597-603.
2003: J Cliff Yoon; Gang Xu; Jude T Deeney; Shao-Nian Yang; James Rhee; Pere Puigserver; Adah R Levens; Ruojing Yang; Chen-Yu zhang; Bradford B Lowell; Per-Olof Berggren; Christopher B Newgard; Susan Bonner-Weir; Gordon Weir; Bruce M Spiegelman
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.
Developmental cell 2003;5(1):73-83.
2003: Vamsi K Mootha; Cecilia M Lindgren; Karl-Fredrik Eriksson; Aravind Subramanian; Smita Sihag; Joseph Lehar; Pere Puigserver; Emma Carlsson; Martin Ridderstråle; Esa Laurila; Nicholas Houstis; Mark J Daly; Nick Patterson; Jill P Mesirov; Todd R Golub; Pablo Tamayo; Bruce M Spiegelman; Eric S Lander; Joel N Hirschhorn; David Altshuler; Leif C Groop
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
Nature genetics 2003;34(3):267-73.
2003: Christoph Handschin; James Rhee; Jiandie Lin; Paul T Tarr; Bruce M Spiegelman
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7111-6.
2003: Harold J Burstein; George D Demetri; Elisabetta Mueller; pasha sarraf; Bruce M Spiegelman; Eric P Winer
Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study.
Breast cancer research and treatment 2003;79(3):391-7.
2003: Pere Puigserver; James Rhee; Jerry Donovan; Christopher J Walkey; J Cliff Yoon; Francesco Oriente; Yukari Kitamura; Jennifer Altomonte; Hengjiang Dong; Domenico Accili; Bruce M Spiegelman
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
Nature 2003;423(6939):550-5.
2003: James Rhee; Yusuke Inoue; J Cliff Yoon; Pere Puigserver; Melina Fan; Frank J Gonzalez; Bruce M Spiegelman
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4012-7.
2003: Pere Puigserver; Bruce M Spiegelman
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator.
Endocrine reviews 2003;24(1):78-90.
2003: Geoffrey D Girnun; Bruce M Spiegelman
PPARgamma ligands: taking Ppart in chemoprevention.
Gastroenterology 2003;124(2):564-7.
2003: Nicholas A Tritos; Jason W Mastaitis; Efi Kokkotou; Pere Puigserver; Bruce M Spiegelman; Eleftheria Maratos-Flier
Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain.
Brain research 2003;961(2):255-60.
2002: Elisabetta Mueller; Stavit Drori; Anita Aiyer; Junming Yie; pasha sarraf; Hong Chen; Stefanie Hauser; Evan D Rosen; Kai Ge; Robert G Roeder; Bruce M Spiegelman
Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms.
The Journal of biological chemistry 2002;277(44):41925-30.
2002: Geoffrey D Girnun; Wendy M Smith; Stavit Drori; pasha sarraf; Elisabetta Mueller; Charis Eng; Prashant R Nambiar; Daniel W Rosenberg; Roderick T Bronson; Winfried Edelmann; Raju Kucherlapati; Frank J Gonzalez; Bruce M Spiegelman
APC-dependent suppression of colon carcinogenesis by PPARgamma.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(21):13771-6.
2002: Matthew H Kulke; George D Demetri; Norman E Sharpless; David P Ryan; Ramesh A Shivdasani; Jeffrey S Clark; Bruce M Spiegelman; Haesook T Kim; Robert J Mayer; Charlie S Fuchs
A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer.
Cancer journal (Sudbury, Mass.) 2002;8(5):395-9.
2002: Jiandie Lin; Hai Wu; Paul T Tarr; Chen-Yu zhang; Zhidan Wu; Olivier Boss; Laura F Michael; Pere Puigserver; Eiji Isotani; Eric N Olson; Bradford B Lowell; Rhonda Bassel-Duby; Bruce M Spiegelman
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.
Nature 2002;418(6899):797-801.
2002: Kai Ge; Mohamed Guermah; Chao-Xing Yuan; Mitsuhiro Ito; Annika E Wallberg; Bruce M Spiegelman; Robert G Roeder
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.
Nature 2002;417(6888):563-7.
2002: Bruce M Spiegelman
The perils of putting career before all else.
Nature 2002;416(6879):365.
2002: Jiandie Lin; Pere Puigserver; Jerry Donovan; Paul Tarr; Bruce M Spiegelman
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.
The Journal of biological chemistry 2002;277(3):1645-8.
2002: Evan D Rosen; Chung-Hsin Hsu; Xinzhong Wang; Shuichi Sakai; Mason W Freeman; Frank J Gonzalez; Bruce M Spiegelman
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway.
Genes & development 2002;16(1):22-6.
2001: Pere Puigserver; James Rhee; Jiandie Lin; Zhidan Wu; J Cliff Yoon; Chen-Yu zhang; S Krauss; Vamsi K Mootha; Bradford B Lowell; Bruce M Spiegelman
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.
Molecular cell 2001;8(5):971-82.
2001: Evan D Rosen; Bruce M Spiegelman
PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth.
The Journal of biological chemistry 2001;276(41):37731-4.
2001: Kyoko Tsukiyama-Kohara; Francis Poulin; M Kohara; Christine T DeMaria; Alan Cheng; Z Wu; Anne-Claude Gingras; Asao Katsume; Mounib Elchebly; Bruce M Spiegelman; M E Harper; Michel L Tremblay; Nahum Sonenberg
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.
Nature medicine 2001;7(10):1128-32.
2001: Stephan Herzig; Fanxin Long; Ulupi S Jhala; Susan Hedrick; R Quinn; anton bauer; D Rudolph; G Schutz; C Yoon; Pere Puigserver; Bruce M Spiegelman; Marc Montminy
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.
Nature 2001;413(6852):179-83.
2001: J Cliff Yoon; Pere Puigserver; G Chen; J Donovan; Zhidan Wu; James Rhee; G Adelmant; J Stafford; C R Kahn; Daryl K Granner; Christopher B Newgard; Bruce M Spiegelman
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
Nature 2001;413(6852):131-8.
2001: L F Michael; Zhidan Wu; R B Cheatham; Pere Puigserver; G Adelmant; J J Lehman; D P Kelly; Bruce M Spiegelman
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3820-5.
2001: Bruce M Spiegelman; J S Flier
Obesity and the regulation of energy balance.
Cell 2001;104(4):531-43.
2001: Kathryn J Moore; Evan D Rosen; Michael L Fitzgerald; F Randow; Lorna P Andersson; D Altshuler; David S Milstone; richard mortensen; Bruce M Spiegelman; Mason W Freeman
The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.
Nature medicine 2001;7(1):41-7.
2000: Bruce M Spiegelman; Pere Puigserver; Z Wu
Regulation of adipogenesis and energy balance by PPARgamma and PGC-1.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24 Suppl 4():S8-10.
2000: Elisabetta Mueller; M Smith; pasha sarraf; Todd G Kroll; A Aiyer; D S Kaufman; William K Oh; George D Demetri; W D Figg; X P Zhou; Charis Eng; Bruce M Spiegelman; Philip W Kantoff
Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10990-5.
2000: E D Rosen; Bruce M Spiegelman
Peroxisome proliferator-activated receptor gamma ligands and atherosclerosis: ending the heartache.
The Journal of clinical investigation 2000;106(5):629-31.
2000: Todd G Kroll; pasha sarraf; L Pecciarini; C J Chen; Elisabetta Mueller; Bruce M Spiegelman; Jonathan A Fletcher
PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected].
Science (New York, N.Y.) 2000;289(5483):1357-60.
2000: M Monsalve; Zhidan Wu; G Adelmant; Pere Puigserver; M Fan; Bruce M Spiegelman
Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.
Molecular cell 2000;6(2):307-16.
2000: J C Yoon; TW Chickering; E D Rosen; BJ Dussault; Y Qin; A Soukas; J M Friedman; W E Holmes; Bruce M Spiegelman
Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.
Molecular and cellular biology 2000;20(14):5343-9.
2000: Stefanie Hauser; G Adelmant; pasha sarraf; HM Wright; Elisabetta Mueller; Bruce M Spiegelman
Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation.
The Journal of biological chemistry 2000;275(24):18527-33.
2000: E D Rosen; C J Walkey; Pere Puigserver; Bruce M Spiegelman
Transcriptional regulation of adipogenesis.
Genes & development 2000;14(11):1293-307.
2000: Irina Tcherepanova; Pere Puigserver; John D Norris; Bruce M Spiegelman; Donald P McDonnell
Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1.
The Journal of biological chemistry 2000;275(21):16302-8.
2000: B B Lowell; Bruce M Spiegelman
Towards a molecular understanding of adaptive thermogenesis.
Nature 2000;404(6778):652-60.
2000: HM Wright; C B Clish; T Mikami; Stefanie Hauser; K Yanagi; R Hiramatsu; C N Serhan; Bruce M Spiegelman
A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation.
The Journal of biological chemistry 2000;275(3):1873-7.
2000: E D Rosen; Bruce M Spiegelman
Molecular regulation of adipogenesis.
Annual review of cell and developmental biology 2000;16():145-71.
1999: Z Wu; Pere Puigserver; Bruce M Spiegelman
Transcriptional activation of adipogenesis.
Current opinion in cell biology 1999;11(6):689-94.
1999: Pere Puigserver; G Adelmant; Zhidan Wu; M Fan; Jianming Xu; Bert W O'Malley; Bruce M Spiegelman
Activation of PPARgamma coactivator-1 through transcription factor docking.
Science (New York, N.Y.) 1999;286(5443):1368-71.
1999: Evan D Rosen; pasha sarraf; AE Troy; G Bradwin; K Moore; David S Milstone; Bruce M Spiegelman; richard mortensen
PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.
Molecular cell 1999;4(4):611-7.
1999: PR Devchand; AK Hihi; M Perroud; W D Schleuning; Bruce M Spiegelman; Walter Wahli
Chemical probes that differentially modulate peroxisome proliferator-activated receptor alpha and BLTR, nuclear and cell surface receptors for leukotriene B(4).
The Journal of biological chemistry 1999;274(33):23341-8.
1999: Lluis Fajas; Kristina Schoonjans; Laurent Gelman; J B Kim; J Najib; G Martin; Jean-Charles Fruchart; M Briggs; Bruce M Spiegelman; Johan Auwerx
Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism.
Molecular and cellular biology 1999;19(8):5495-503.
1999: DE Tabor; JB Kim; Bruce M Spiegelman; Peter A Edwards
Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2.
The Journal of biological chemistry 1999;274(29):20603-10.
1999: Zhidan Wu; Pere Puigserver; Ulf Andersson; C Zhang; G Adelmant; Vamsi K Mootha; AE Troy; Saverio Cinti; Bradford B Lowell; R C Scarpulla; Bruce M Spiegelman
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
Cell 1999;98(1):115-24.
1999: G Castillo; R P Brun; J K Rosenfield; S Hauser; C W Park; AE Troy; Margaret E. Wright; Bruce M Spiegelman
An adipogenic cofactor bound by the differentiation domain of PPARgamma.
The EMBO journal 1999;18(13):3676-87.
1999: pasha sarraf; Elisabetta Mueller; W M Smith; HM Wright; J B Kum; L A Aaltonen; ALBERT DE LA CHAPELLE; Bruce M Spiegelman; Charis Eng
Loss-of-function mutations in PPAR gamma associated with human colon cancer.
Molecular cell 1999;3(6):799-804.
1999: J H Devine; Darrell W Eubank; D E Clouthier; P Tontonoz; Bruce M Spiegelman; Robert E Hammer; Elmus G Beale
Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo.
The Journal of biological chemistry 1999;274(19):13604-12.
1999: George D Demetri; Christopher D M Fletcher; Elisabetta Mueller; pasha sarraf; R Naujoks; N Campbell; Bruce M Spiegelman; Samuel Singer
Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3951-6.
1999: F J King; E Hu; D F Harris; pasha sarraf; Bruce M Spiegelman; Thomas M Roberts
DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines.
Molecular and cellular biology 1999;19(3):2330-7.
1999: Zhidan Wu; Evan D Rosen; R Brun; S Hauser; G Adelmant; AE Troy; C McKeon; G J Darlington; Bruce M Spiegelman
Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.
Molecular cell 1999;3(2):151-8.
1998: I-Cheng Ho; J H Kim; J W Rooney; Bruce M Spiegelman; Laurie H Glimcher
A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15537-41.
1998: Hiroshi Sakaue; Wataru Ogawa; Michihiro Matsumoto; Shun'ichi Kuroda; M Takata; Toshitsugu Sugimoto; Bruce M Spiegelman; Masato Kasuga
Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase.
The Journal of biological chemistry 1998;273(44):28945-52.
1998: pasha sarraf; Elisabetta Mueller; D Jones; F J King; Daniel J DeAngelo; J B Partridge; S A Holden; Lan Bo Chen; Samuel Singer; C Fletcher; Bruce M Spiegelman
Differentiation and reversal of malignant changes in colon cancer through PPARgamma.
Nature medicine 1998;4(9):1046-52.
1998: DE Tabor; JB Kim; Bruce M Spiegelman; Peter A Edwards
Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1.
The Journal of biological chemistry 1998;273(34):22052-8.
1998: P Peraldi; Bruce M Spiegelman
TNF-alpha and insulin resistance: summary and future prospects.
Molecular and cellular biochemistry 1998;182(1-2):169-75.
1998: Lidia I Serova; E Saez; Bruce M Spiegelman; Esther L Sabban
c-Fos deficiency inhibits induction of mRNA for some, but not all, neurotransmitter biosynthetic enzymes by immobilization stress.
Journal of neurochemistry 1998;70(5):1935-40.
1998: Bruce M Spiegelman
PPARgamma in monocytes: less pain, any gain?
Cell 1998;93(2):153-5.
1998: J B Kim; H M Wright; Margaret E. Wright; Bruce M Spiegelman
ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4333-7.
1998: Bruce M Spiegelman
PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
Diabetes 1998;47(4):507-14.
1998: Pere Puigserver; Zhidan Wu; C W Park; R Graves; Margaret E. Wright; Bruce M Spiegelman
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Cell 1998;92(6):829-39.
1998: Elisabetta Mueller; pasha sarraf; P Tontonoz; R M Evans; K J Martin; M Zhang; C Fletcher; Samuel Singer; Bruce M Spiegelman
Terminal differentiation of human breast cancer through PPAR gamma.
Molecular cell 1998;1(3):465-70.
1998: J B Kim; pasha sarraf; Margaret E. Wright; K M Yao; E Mueller; Gemma Solanes; Bradford B Lowell; Bruce M Spiegelman
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.
The Journal of clinical investigation 1998;101(1):1-9.
1997: Bruce M Spiegelman
Peroxisome proliferator-activated receptor gamma: A key regulator of adipogenesis and systemic insulin sensitivity.
European journal of medical research 1997;2(11):457-64.
1997: P Peraldi; Bruce M Spiegelman
Studies of the mechanism of inhibition of insulin signaling by tumor necrosis factor-alpha.
The Journal of endocrinology 1997;155(2):219-20.
1997: R P Brun; Bruce M Spiegelman
PPAR gamma and the molecular control of adipogenesis.
The Journal of endocrinology 1997;155(2):217-8.
1997: P Peraldi; M Xu; Bruce M Spiegelman
Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.
The Journal of clinical investigation 1997;100(7):1863-9.
1997: Susan Rutberg; E Saez; S Lo; S I Jang; Nelli G Markova; Bruce M Spiegelman; Stuart H Yuspa
Opposing activities of c-Fos and Fra-2 on AP-1 regulated transcriptional activity in mouse keratinocytes induced to differentiate by calcium and phorbol esters.
Oncogene 1997;15(11):1337-46.
1997: S Altiok; M Xu; Bruce M Spiegelman
PPARgamma induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A.
Genes & development 1997;11(15):1987-98.
1997: R P Brun; J B Kim; E Hu; Bruce M Spiegelman
Peroxisome proliferator-activated receptor gamma and the control of adipogenesis.
Current opinion in lipidology 1997;8(4):212-8.
1997: Carrolee Barlow; M Schroeder; Julie Lekstrom-Himes; H Kylefjord; Chu-Xia Deng; Anthony Wynshaw-Boris; Bruce M Spiegelman; Kleanthis G Xanthopoulos
Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments.
Nucleic acids research 1997;25(12):2543-5.
1997: J Ericsson; SM Jackson; JB Kim; Bruce M Spiegelman; Peter A Edwards
Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene.
The Journal of biological chemistry 1997;272(11):7298-305.
1997: G S Hotamisligil; P Arner; R L Atkinson; Bruce M Spiegelman
Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance.
Diabetes 1997;46(3):451-5.
1997: A N Hollenberg; VS Susulic; J P Madura; Bin Zhang; D E Moller; P Tontonoz; pasha sarraf; Bruce M Spiegelman; Bradford B Lowell
Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter.
The Journal of biological chemistry 1997;272(8):5283-90.
1997: Bruce M Spiegelman; E Hu; J B Kim; R Brun
PPAR gamma and the control of adipogenesis.
Biochimie 1997;79(2-3):111-2.
1997: P Tontonoz; Samuel Singer; B M Forman; pasha sarraf; Jonathan A Fletcher; Christopher D M Fletcher; R P Brun; Elisabetta Mueller; S Altiok; H Oppenheim; Ronald M Evans; Bruce M Spiegelman
Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):237-41.
1997: P Peraldi; Bruce M Spiegelman
[TNF-alpha: molecular tie between obesity and insulin resistance].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1997;():149-59.
1997: E Hu; Bruce M Spiegelman
Identification of novel genes involved in adipose differentiation by differential display.
Methods in molecular biology (Clifton, N.J.) 1997;85():195-204.
1997: V Soloveva; R A Graves; Mark M Rasenick; Bruce M Spiegelman; Susan R Ross
Transgenic mice overexpressing the beta 1-adrenergic receptor in adipose tissue are resistant to obesity.
Molecular endocrinology (Baltimore, Md.) 1997;11(1):27-38.
1996: E Hu; J B Kim; pasha sarraf; Bruce M Spiegelman
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma.
Science (New York, N.Y.) 1996;274(5295):2100-3.
1996: R P Brun; J B Kim; E Hu; S Altiok; Bruce M Spiegelman
Adipocyte differentiation: a transcriptional regulatory cascade.
Current opinion in cell biology 1996;8(6):826-32.
1996: Gökhan S Hotamisligil; R S Johnson; Robert Distel; R Ellis; V E Papaioannou; Bruce M Spiegelman
Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.
Science (New York, N.Y.) 1996;274(5291):1377-9.
1996: L N Choy; Bruce M Spiegelman
Regulation of alternative pathway activation and C3a production by adipose cells.
Obesity research 1996;4(6):521-32.
1996: B Zhang; J Berger; E Hu; Deborah Szalkowski; S White-Carrington; Bruce M Spiegelman; David E Moller
Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha.
Molecular endocrinology (Baltimore, Md.) 1996;10(11):1457-66.
1996: Bruce M Spiegelman; J S Flier
Adipogenesis and obesity: rounding out the big picture.
Cell 1996;87(3):377-89.
1996: Susan Rutberg; E Saez; A Glick; Andrzej Dlugosz; Bruce M Spiegelman; Stuart H Yuspa
Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins.
Oncogene 1996;13(1):167-76.
1996: Y Watanabe; R S Johnson; L S Butler; D K Binder; Bruce M Spiegelman; V E Papaioannou; James O McNamara
Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(12):3827-36.
1996: P Peraldi; G S Hotamisligil; W A Buurman; M F White; Bruce M Spiegelman
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase.
The Journal of biological chemistry 1996;271(22):13018-22.
1996: E Hu; P Liang; Bruce M Spiegelman
AdipoQ is a novel adipose-specific gene dysregulated in obesity.
The Journal of biological chemistry 1996;271(18):10697-703.
1996: J B Kim; Bruce M Spiegelman
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.
Genes & development 1996;10(9):1096-107.
1996: R P Brun; P Tontonoz; B M Forman; R Ellis; J Chen; Ronald M Evans; Bruce M Spiegelman
Differential activation of adipogenesis by multiple PPAR isoforms.
Genes & development 1996;10(8):974-84.
1996: G I Honrado; R S Johnson; Diego A Golombek; Bruce M Spiegelman; V E Papaioannou; Martin R Ralph
The circadian system of c-fos deficient mice.
Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 1996;178(4):563-70.
1996: G S Hotamisligil; P Peraldi; A Budavari; R Ellis; M F White; Bruce M Spiegelman
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.
Science (New York, N.Y.) 1996;271(5249):665-8.
1995: E Saez; H Oppenheim; J Smoluk; J W Andersen; R A Van Etten; Bruce M Spiegelman
c-fos is not essential for v-abl-induced lymphomagenesis.
Cancer research 1995;55(24):6196-9.
1995: B M Forman; P Tontonoz; J Chen; R P Brun; Bruce M Spiegelman; Ronald M Evans
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.
Cell 1995;83(5):803-12.
1995: E Hu; P Tontonoz; Bruce M Spiegelman
Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9856-60.
1995: P Tontonoz; E Hu; Bruce M Spiegelman
Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma.
Current opinion in genetics & development 1995;5(5):571-6.
1995: E Saez; Susan Rutberg; Elisabetta Mueller; H Oppenheim; J Smoluk; Stuart H Yuspa; Bruce M Spiegelman
c-fos is required for malignant progression of skin tumors.
Cell 1995;82(5):721-32.
1995: Susan R Ross; R A Graves; L Choy; V Soleveva; Bruce M Spiegelman
Transgenic mouse models of disease: altering adipose tissue function in vivo.
Annals of the New York Academy of Sciences 1995;758():297-313.
1995: J B Kim; G D Spotts; Y D Halvorsen; H M Shih; T Ellenberger; H C Towle; Bruce M Spiegelman
Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain.
Molecular and cellular biology 1995;15(5):2582-8.
1995: G S Hotamisligil; P Arner; J F Caro; R L Atkinson; Bruce M Spiegelman
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
The Journal of clinical investigation 1995;95(5):2409-15.
1995: Kevin P Claffey; D R Senger; Bruce M Spiegelman
Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF.
Biochimica et biophysica acta 1995;1246(1):1-9.
1995: P Tontonoz; E Hu; J Devine; E G Beale; Bruce M Spiegelman
PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene.
Molecular and cellular biology 1995;15(1):351-7.
1994: P Tontonoz; E Hu; Bruce M Spiegelman
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.
Cell 1994;79(7):1147-56.
1994: P Tontonoz; R A Graves; A I Budavari; H Erdjument-Bromage; M Lui; E Hu; Paul Tempst; Bruce M Spiegelman
Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha.
Nucleic acids research 1994;22(25):5628-34.
1994: K A Platt; K P Claffey; W O Wilkison; Bruce M Spiegelman; Susan R Ross
Independent regulation of adipose tissue-specificity and obesity response of the adipsin promoter in transgenic mice.
The Journal of biological chemistry 1994;269(46):28558-62.
1994: G S Hotamisligil; Bruce M Spiegelman
Tumor necrosis factor alpha: a key component of the obesity-diabetes link.
Diabetes 1994;43(11):1271-8.
1994: G S Hotamisligil; A Budavari; D Murray; Bruce M Spiegelman
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
The Journal of clinical investigation 1994;94(4):1543-9.
1994: Richard Paylor; R S Johnson; V Papaioannou; Bruce M Spiegelman; Jeanne M Wehner
Behavioral assessment of c-fos mutant mice.
Brain research 1994;651(1-2):275-82.
1994: E Hu; E Mueller; S Oliviero; V E Papaioannou; R Johnson; Bruce M Spiegelman
Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes.
The EMBO journal 1994;13(13):3094-103.
1994: G S Hotamisligil; D L Murray; L N Choy; Bruce M Spiegelman
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4854-8.
1994: P Tontonoz; E Hu; R A Graves; A I Budavari; Bruce M Spiegelman
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
Genes & development 1994;8(10):1224-34.
1994: J Jain; E A Nalefski; P G McCaffrey; R S Johnson; Bruce M Spiegelman; V Papaioannou; Anjana Rao
Normal peripheral T-cell function in c-Fos-deficient mice.
Molecular and cellular biology 1994;14(3):1566-74.
1994: C Hofmann; K Lorenz; Susan Braithwaite; J R Colca; B J Palazuk; G S Hotamisligil; Bruce M Spiegelman
Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.
Endocrinology 1994;134(1):264-70.
1994: S Klaus; L Choy; O Champigny; Anne-Marie Cassard-Doulcier; S Ross; Bruce M Spiegelman; Daniel Ricquier
Characterization of the novel brown adipocyte cell line HIB 1B. Adrenergic pathways involved in regulation of uncoupling protein gene expression.
Journal of cell science 1994;107 ( Pt 1)():313-9.
1993: Y D Halvorsen; Sven-Erik Bursell; W O Wilkison; Allen Clermont; M Brittis; T J McGovern; Bruce M Spiegelman
Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes.
The Journal of clinical investigation 1993;92(6):2872-6.
1993: P Tontonoz; J B Kim; R A Graves; Bruce M Spiegelman
ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.
Molecular and cellular biology 1993;13(8):4753-9.
1993: Susan R Ross; R A Graves; Bruce M Spiegelman
Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity.
Genes & development 1993;7(7B):1318-24.
1993: R S Johnson; B van Lingen; V E Papaioannou; Bruce M Spiegelman
A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.
Genes & development 1993;7(7B):1309-17.
1993: M Pascual; E Catana; T White; Bruce M Spiegelman; J A Schifferli
Inhibition of complement alternative pathway in mice with Fab antibody to recombinant adipsin/factor D.
European journal of immunology 1993;23(6):1389-92.
1993: Bruce M Spiegelman; G S Hotamisligil
Through thick and thin: wasting, obesity, and TNF alpha.
Cell 1993;73(4):625-7.
1993: Bruce M Spiegelman; L Choy; G S Hotamisligil; R A Graves; P Tontonoz
Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.
The Journal of biological chemistry 1993;268(10):6823-6.
1993: W O Wilkison; Bruce M Spiegelman
Biosynthesis of the vasoactive lipid monobutyrin. Central role of diacylglycerol.
The Journal of biological chemistry 1993;268(4):2844-9.
1993: G S Hotamisligil; N S Shargill; Bruce M Spiegelman
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
Science (New York, N.Y.) 1993;259(5091):87-91.
1992: R S Johnson; Bruce M Spiegelman; V Papaioannou
Pleiotropic effects of a null mutation in the c-fos proto-oncogene.
Cell 1992;71(4):577-86.
1992: S J Field; R S Johnson; richard mortensen; Virginia E Papaioannou; Bruce M Spiegelman; Michael E Greenberg
Growth and differentiation of embryonic stem cells that lack an intact c-fos gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9306-10.
1992: S Oliviero; G S Robinson; Kevin Struhl; Bruce M Spiegelman
Yeast GCN4 as a probe for oncogenesis by AP-1 transcription factors: transcriptional activation through AP-1 sites is not sufficient for cellular transformation.
Genes & development 1992;6(9):1799-809.
1992: K P Claffey; W O Wilkison; Bruce M Spiegelman
Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.
The Journal of biological chemistry 1992;267(23):16317-22.
1992: Susan R Ross; L Choy; R A Graves; N Fox; V Solevjeva; S Klaus; Daniel Ricquier; Bruce M Spiegelman
Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7561-5.
1992: R A Graves; P Tontonoz; K A Platt; Susan R Ross; Bruce M Spiegelman
Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression.
Journal of cellular biochemistry 1992;49(3):219-24.
1992: R A Graves; P Tontonoz; Bruce M Spiegelman
Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.
Molecular and cellular biology 1992;12(7):3313.
1992: L N Choy; B S Rosen; Bruce M Spiegelman
Adipsin and an endogenous pathway of complement from adipose cells.
The Journal of biological chemistry 1992;267(18):12736-41.
1992: R T White; D Damm; N Hancock; B S Rosen; Bradford B Lowell; P Usher; Jeffrey S Flier; Bruce M Spiegelman
Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue.
The Journal of biological chemistry 1992;267(13):9210-3.
1992: Robert Distel; G S Robinson; Bruce M Spiegelman
Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms.
The Journal of biological chemistry 1992;267(9):5937-41.
1992: R A Graves; P Tontonoz; Bruce M Spiegelman
Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression.
Molecular and cellular biology 1992;12(3):1202-8.
1991: W O Wilkison; L Choy; Bruce M Spiegelman
Biosynthetic regulation of monobutyrin, an adipocyte-secreted lipid with angiogenic activity.
The Journal of biological chemistry 1991;266(25):16886-91.
1991: R A Graves; P Tontonoz; Susan R Ross; Bruce M Spiegelman
Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor.
Genes & development 1991;5(3):428-37.
1990: Susan R Ross; R A Graves; A Greenstein; K A Platt; H L Shyu; B Mellovitz; Bruce M Spiegelman
A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9590-4.
1990: R Herrera; S Agarwal; K Walton; B Satterberg; Robert Distel; Richard H Goodman; Bruce M Spiegelman; Thomas M Roberts
A direct role for c-fos in AP-1-dependent gene transcription.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(10):483-90.
1990: D E Dobson; A Kambe; E Block; T Dion; H Lu; J J Castellot; Bruce M Spiegelman
1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes.
Cell 1990;61(2):223-30.
1990: E A Allegretto; T Smeal; Peter Angel; Bruce M Spiegelman; Michael Karin
DNA-binding activity of Jun is increased through its interaction with Fos.
Journal of cellular biochemistry 1990;42(4):193-206.
1990: Bradford B Lowell; A Napolitano; P Usher; A G Dulloo; B S Rosen; Bruce M Spiegelman; Jeffrey S Flier
Reduced adipsin expression in murine obesity: effect of age and treatment with the sympathomimetic-thermogenic drug mixture ephedrine and caffeine.
Endocrinology 1990;126(3):1514-20.
1990: W O Wilkison; H Y Min; K P Claffey; B L Satterberg; Bruce M Spiegelman
Control of the adipsin gene in adipocyte differentiation. Identification of distinct nuclear factors binding to single- and double-stranded DNA.
The Journal of biological chemistry 1990;265(1):477-82.
1990: Robert Distel; Bruce M Spiegelman
Protooncogene c-fos as a transcription factor.
Advances in cancer research 1990;55():37-55.
1989: R Herrera; H S Ro; G S Robinson; Kleanthis G Xanthopoulos; Bruce M Spiegelman
A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation.
Molecular and cellular biology 1989;9(12):5331-9.
1989: K Kitagawa; B S Rosen; Bruce M Spiegelman; Gustav E Lienhard; L I Tanner
Insulin stimulates the acute release of adipsin from 3T3-L1 adipocytes.
Biochimica et biophysica acta 1989;1014(1):83-9.
1989: K A Platt; H Y Min; Susan R Ross; Bruce M Spiegelman
Obesity-linked regulation of the adipsin gene promoter in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7490-4.
1989: R S Johnson; Morgan Sheng; M E Greenberg; Richard D Kolodner; V E Papaioannou; Bruce M Spiegelman
Targeting of nonexpressed genes in embryonic stem cells via homologous recombination.
Science (New York, N.Y.) 1989;245(4923):1234-6.
1989: B S Rosen; K S Cook; J Yaglom; D L Groves; J E Volanakis; D Damm; T White; Bruce M Spiegelman
Adipsin and complement factor D activity: an immune-related defect in obesity.
Science (New York, N.Y.) 1989;244(4911):1483-7.
1989: Bruce M Spiegelman; Bradford B Lowell; A Napolitano; P Dubuc; D Barton; U Francke; D L Groves; K S Cook; Jeffrey S Flier
Adrenal glucocorticoids regulate adipsin gene expression in genetically obese mice.
The Journal of biological chemistry 1989;264(3):1811-5.
1989: Jeffrey S Flier; Bradford B Lowell; A Napolitano; P Usher; B Rosen; K S Cook; Bruce M Spiegelman
Adipsin: regulation and dysregulation in obesity and other metabolic states.
Recent progress in hormone research 1989;45():567-80; discussion 580-1.
1988: Bruce M Spiegelman; Robert Distel; H S Ro; B S Rosen; B Satterberg
fos protooncogene and the regulation of gene expression in adipocyte differentiation.
The Journal of cell biology 1988;107(3):829-32.
1988: Bruce M Spiegelman
Regulation of gene expression in the adipocyte: implications for obesity and proto-oncogene function.
Trends in genetics : TIG 1988;4(7):203-7.
1988: V Cherington; Myles Brown; E Paucha; J St Louis; Bruce M Spiegelman; Thomas M Roberts
Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation.
Molecular and cellular biology 1988;8(3):1380-4.
1988: Frank J Rauscher; L C Sambucetti; Tom Curran; Robert Distel; Bruce M Spiegelman
Common DNA binding site for Fos protein complexes and transcription factor AP-1.
Cell 1988;52(3):471-80.
1988: Robert Distel; Bruce M Spiegelman
Involvement of fos as a trans-acting factor in adipogenic gene expression.
Progress in clinical and biological research 1988;284():187-209.
1987: Jeffrey S Flier; K S Cook; P Usher; Bruce M Spiegelman
Severely impaired adipsin expression in genetic and acquired obesity.
Science (New York, N.Y.) 1987;237(4813):405-8.
1987: K S Cook; H Y Min; D Johnson; R J Chaplinsky; Jeffrey S Flier; C R Hunt; Bruce M Spiegelman
Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve.
Science (New York, N.Y.) 1987;237(4813):402-5.
1987: Robert Distel; H S Ro; B S Rosen; D L Groves; Bruce M Spiegelman
Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos.
Cell 1987;49(6):835-44.
1987: D E Dobson; D L Groves; Bruce M Spiegelman
Nucleotide sequence and hormonal regulation of mouse glycerophosphate dehydrogenase mRNA during adipocyte and muscle cell differentiation.
The Journal of biological chemistry 1987;262(4):1804-9.
1986: H Y Min; Bruce M Spiegelman
Adipsin, the adipocyte serine protease: gene structure and control of expression by tumor necrosis factor.
Nucleic acids research 1986;14(22):8879-92.
1986: C R Hunt; J H Ro; D E Dobson; H Y Min; Bruce M Spiegelman
Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(11):3786-90.
1986: V Cherington; B Morgan; Bruce M Spiegelman; Thomas M Roberts
Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(12):4307-11.
1986: J J Castellot; A M Kambe; D E Dobson; Bruce M Spiegelman
Heparin potentiation of 3T3-adipocyte stimulated angiogenesis: mechanisms of action on endothelial cells.
Journal of cellular physiology 1986;127(2):323-9.
1986: Bruce M Spiegelman; K S Cook; C R Hunt
Regulation of gene expression during the differentiation of 3T3-adipocytes.
Progress in clinical and biological research 1986;226():445-54.
1985: K S Cook; D L Groves; H Y Min; Bruce M Spiegelman
A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(19):6480-4.
1985: K S Cook; C R Hunt; Bruce M Spiegelman
Developmentally regulated mRNAs in 3T3-adipocytes: analysis of transcriptional control.
The Journal of cell biology 1985;100(2):514-20.
1983: Bruce M Spiegelman; C A Ginty
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes.
Cell 1983;35(3 Pt 2):657-66.
1983: Bruce M Spiegelman; M Frank; H Green
Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development.
The Journal of biological chemistry 1983;258(16):10083-9.
1982: J J Castellot; M J Karnovsky; Bruce M Spiegelman
Differentiation-dependent stimulation of neovascularization and endothelial cell chemotaxis by 3T3 adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(18):5597-601.
1982: Bruce M Spiegelman; S R Farmer
Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 adipocytes.
Cell 1982;29(1):53-60.
1981: Bruce M Spiegelman; H Green
Cyclic AMP-mediated control of lipogenic enzyme synthesis during adipose differentiation of 3T3 cells.
Cell 1981;24(2):503-10.
1980: J J Castellot; M J Karnovsky; Bruce M Spiegelman
Potent stimulation of vascular endothelial cell growth by differentiated 3T3 adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(10):6007-11.
1980: Bruce M Spiegelman; H Green
Control of specific protein biosynthesis during the adipose conversion of 3T3 cells.
The Journal of biological chemistry 1980;255(18):8811-18.
1979: D W Cleveland; Bruce M Spiegelman; M W Kirschner
Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins.
The Journal of biological chemistry 1979;254(24):12670-8.