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George Spiegelman

Research Profile

Living Beings

Bacillus subtilis

Physiology

Chemicals & Drugs

Concepts & Ideas

Anatomy

Spores, Bacterial

Phenomena

Phosphorylation

Genes & Molecular Sequences

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Publications

TOP 3
Parvin Bolourani; George B Spiegelman; Gerald Weeks
Determinants of RasC specificity during Dictyostelium aggregation.
Parvin Bolourani; George B Spiegelman; Gerald Weeks
Ras proteins have multiple functions in vegetative cells of Dictyostelium.
Jared L Taylor; Karen M Smith; Adrian P van Stolk; George B Spiegelman
Using invention to change how students tackle problems.

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All Publications

2010: Parvin Bolourani; George B Spiegelman; Gerald Weeks
Determinants of RasC specificity during Dictyostelium aggregation.
The Journal of biological chemistry 2010;285(53):41374-9.
2010: Parvin Bolourani; George B Spiegelman; Gerald Weeks
Ras proteins have multiple functions in vegetative cells of Dictyostelium.
Eukaryotic cell 2010;9(11):1728-33.
2010: Jared L Taylor; Karen M Smith; Adrian P van Stolk; George B Spiegelman
Using invention to change how students tackle problems.
CBE life sciences education 2010;9(4):504-12.
2009: Steve D Seredick; Barbara M Seredick; David Baker; George B Spiegelman
An A257V mutation in the bacillus subtilis response regulator Spo0A prevents regulated expression of promoters with low-consensus binding sites.
Journal of bacteriology 2009;191(17):5489-98.
2008: Parvin Bolourani; George B Spiegelman; Gerald Weeks
Rap1 activation in response to cAMP occurs downstream of ras activation during Dictyostelium aggregation.
The Journal of biological chemistry 2008;283(16):10232-40.
2007: Helmut Kae; Arjan Kortholt; Holger Rehmann; Robert H Insall; peter van haastert; George B Spiegelman; Gerald Weeks
Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs.
EMBO reports 2007;8(5):477-82.
2007: Steve D Seredick; George B Spiegelman
Bacillus subtilis RNA polymerase recruits the transcription factor Spo0A approximately P to stabilize a closed complex during transcription initiation.
Journal of molecular biology 2007;366(1):19-35.
2006: Grace Yim; Fernando de la Cruz; George B Spiegelman; Julian Davies
Transcription modulation of Salmonella enterica serovar Typhimurium promoters by sub-MIC levels of rifampin.
Journal of bacteriology 2006;188(22):7988-91.
2006: Julian Davies; George B Spiegelman; Grace Yim
The world of subinhibitory antibiotic concentrations.
Current opinion in microbiology 2006;9(5):445-53.
2006: Parvin Bolourani; George B Spiegelman; Gerald Weeks
Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum.
Molecular biology of the cell 2006;17(10):4543-50.
2006: David M Secko; Chi-Hung Siu; George B Spiegelman; Gerald Weeks
An activated Ras protein alters cell adhesion by dephosphorylating Dictyostelium DdCAD-1.
Microbiology (Reading, England) 2006;152(Pt 5):1497-505.
2006: Meenal Khosla; Paul W Kriebel; Carole A Parent; George B Spiegelman; Gerald Weeks
A secondary disruption of the dmpA gene encoding a large membrane protein allows aggregation defective Dictyostelium rasC- cells to form multicellular structures.
Developmental biology 2006;292(1):68-78.
2005: Meenal Khosla; George B Spiegelman; Gerald Weeks
The effect of the disruption of a gene encoding a PI4 kinase on the developmental defect exhibited by Dictyostelium rasC(-) cells.
Developmental biology 2005;284(2):412-20.
2005: Chinten James Lim; Karl A Zawadzki; Meenal Khosla; David M Secko; George B Spiegelman; Gerald Weeks
Loss of the Dictyostelium RasC protein alters vegetative cell size, motility and endocytosis.
Experimental cell research 2005;306(1):47-55.
2005: Brett N McLeod; George B Spiegelman
Soj antagonizes Spo0A activation of transcription in Bacillus subtilis.
Journal of bacteriology 2005;187(7):2532-6.
2004: David M Secko; Robert H Insall; George B Spiegelman; Gerald Weeks
The identification of Dictyostelium phosphoproteins altered in response to the activation of RasG.
Proteomics 2004;4(9):2629-39.
2004: Deborah Wessels; Rebecca Brincks; Spencer Kuhl; Vesna Stepanovic; Karla J Daniels; Gerald Weeks; Chinten James Lim; George B Spiegelman; Danny Fuller; Negin Iranfar; William F Loomis; David Soll
RasC plays a role in transduction of temporal gradient information in the cyclic-AMP wave of Dictyostelium discoideum.
Eukaryotic cell 2004;3(3):646-62.
2004: Helmut Kae; Chinten James Lim; George B Spiegelman; Gerald Weeks
Chemoattractant-induced Ras activation during Dictyostelium aggregation.
EMBO reports 2004;5(6):602-6.
2004: Steve D Seredick; George B Spiegelman
The Bacillus subtilis response regulator Spo0A stimulates sigmaA-dependent transcription prior to the major energetic barrier.
The Journal of biological chemistry 2004;279(17):17397-403.
2003: Gerald Weeks; George B Spiegelman
Roles played by Ras subfamily proteins in the cell and developmental biology of microorganisms.
Cellular signalling 2003;15(10):901-9.
2003: Steve D Seredick; Barbara M Turner; George B Spiegelman
Assay of transcription modulation by SpoOA of Bacillus subtilis.
Methods in enzymology 2003;370():312-23.
2002: Rujun Kang; Helmut Kae; Hermia Ip; George B Spiegelman; Gerald Weeks
Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress.
Journal of cell science 2002;115(Pt 18):3675-82.
2002: Laurie G Dixon; George B Spiegelman
Glucose-resistant sporulation in Bacillus subtilis crsA47 mutants does not depend on promoter switching at the spo0A gene.
Journal of bacteriology 2002;184(5):1458-61.
2002: Richard J Lewis; David Scott; James A Brannigan; Joanne C Ladds; Marguerite A Cervin; George B Spiegelman; James G Hoggett; imrich barak; Anthony J Wilkinson
Dimer formation and transcription activation in the sporulation response regulator Spo0A.
Journal of molecular biology 2002;316(2):235-45.
2002: Chinten James Lim; George B Spiegelman; Gerald Weeks
Cytoskeletal regulation by Dictyostelium Ras subfamily proteins.
Journal of muscle research and cell motility 2002;23(7-8):729-36.
2001: B W Sutherland; George B Spiegelman; Gerald Weeks
A Ras subfamily GTPase shows cell cycle-dependent nuclear localization.
EMBO reports 2001;2(11):1024-8.
2001: Chinten James Lim; George B Spiegelman; Gerald Weeks
RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation.
The EMBO journal 2001;20(16):4490-9.
2001: L G Dixon; Steve D Seredick; Martin J Richer; George B Spiegelman
Developmental gene expression in Bacillus subtilis crsA47 mutants reveals glucose-activated control of the gene for the minor sigma factor sigma(H).
Journal of bacteriology 2001;183(16):4814-22.
2001: David M Secko; Meenal Khosla; Pascale Gaudet; Adrian Tsang; George B Spiegelman; Gerald Weeks
RasG regulates discoidin gene expression during Dictyostelium growth.
Experimental cell research 2001;266(1):135-41.
2001: Steve D Seredick; George B Spiegelman
Lessons and questions from the structure of the Spo0A activation domain.
Trends in microbiology 2001;9(4):148-51.
2001: Z M Jaffer; Meenal Khosla; George B Spiegelman; Gerald Weeks
Expression of activated Ras during Dictyostelium development alters cell localization and changes cell fate.
Development (Cambridge, England) 2001;128(6):907-16.
2000: DA Rowe-Magnus; Martin J Richer; George B Spiegelman
Identification of a second region of the Spo0A response regulator of Bacillus subtilis required for transcription activation.
Journal of bacteriology 2000;182(15):4352-5.
2000: Marguerite A Cervin; George B Spiegelman
A role for Asp75 in domain interactions in the Bacillus subtilis response regulator Spo0A.
The Journal of biological chemistry 2000;275(29):22025-30.
2000: Andrew Wilkins; Meenal Khosla; Derek J Fraser; George B Spiegelman; Paul R Fisher; Gerald Weeks; Robert H Insall
Dictyostelium RasD is required for normal phototaxis, but not differentiation.
Genes & development 2000;14(11):1407-13.
2000: Meenal Khosla; George B Spiegelman; Robert H Insall; Gerald Weeks
Functional overlap of the dictyostelium RasG, RasD and RasB proteins.
Journal of cell science 2000;113 ( Pt 8)():1427-34.
1999: T Zhang; PJ Rebstein; Meenal Khosla; James A Cardelli; G Buczynski; Jason Bush; George B Spiegelman; Gerald Weeks
A mutation that separates the RasG signals that regulate development and cytoskeletal function in Dictyostelium.
Experimental cell research 1999;247(2):356-66.
1999: DJ Seastone; L Zhang; G Buczynski; PJ Rebstein; Gerald Weeks; George B Spiegelman; James A Cardelli
The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum.
Molecular biology of the cell 1999;10(2):393-406.
1999: Marguerite A Cervin; George B Spiegelman
The Spo0A sof mutations reveal regions of the regulatory domain that interact with a sensor kinase and RNA polymerase.
Molecular microbiology 1999;31(2):597-607.
1998: DA Rowe-Magnus; George B Spiegelman
Contributions of the domains of the Bacillus subtilis response regulator Spo0A to transcription stimulation of the spoIIG operon.
The Journal of biological chemistry 1998;273(40):25818-24.
1998: DA Rowe-Magnus; M Mencía; Fernando Rojo; Margarita Salas; George B Spiegelman
Transcriptional activation of the Bacillus subtilis spoIIG promoter by the response regulator Spo0A is independent of the C-terminal domain of the RNA polymerase alpha subunit.
Journal of bacteriology 1998;180(17):4760-3.
1998: Marguerite A Cervin; Richard J Lewis; James A Brannigan; George B Spiegelman
The Bacillus subtilis regulator SinR inhibits spoIIG promoter transcription in vitro without displacing RNA polymerase.
Nucleic acids research 1998;26(16):3806-12.
1998: Marguerite A Cervin; George B Spiegelman; Brian Raether; K Ohlsen; Marta Perego; James A Hoch
A negative regulator linking chromosome segregation to developmental transcription in Bacillus subtilis.
Molecular microbiology 1998;29(1):85-95.
1998: DA Rowe-Magnus; George B Spiegelman
DNA strand separation during activation of a developmental promoter by the Bacillus subtilis response regulator Spo0A.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5305-10.
1997: Sharon Louis; Gerald Weeks; George B Spiegelman
Rap1 overexpression reveals that activated RasD induces separable defects during Dictyostelium development.
Developmental biology 1997;190(2):273-83.
1997: R C Mottus; Ian P Whitehead; M O'Grady; R E Sobel; R H Burr; George B Spiegelman; Thomas A Grigliatti
Unique gene organization: alternative splicing in Drosophila produces two structurally unrelated proteins.
Gene 1997;198(1-2):229-36.
1997: PJ Rebstein; James A Cardelli; Gerald Weeks; George B Spiegelman
Mutational analysis of the role of Rap1 in regulating cytoskeletal function in Dictyostelium.
Experimental cell research 1997;231(2):276-83.
1997: Sharon Louis; George B Spiegelman; Gerald Weeks
Expression of an activated rasD gene changes cell fate decisions during Dictyostelium development.
Molecular biology of the cell 1997;8(2):303-12.
1996: M Khosla; George B Spiegelman; Gerald Weeks
Overexpression of an activated rasG gene during growth blocks the initiation of Dictyostelium development.
Molecular and cellular biology 1996;16(8):4156-62.
1996: E A Greene; George B Spiegelman
The Spo0A protein of Bacillus subtilis inhibits transcription of the abrB gene without preventing binding of the polymerase to the promoter.
The Journal of biological chemistry 1996;271(19):11455-61.
1996: T H Bird; J K Grimsley; James A Hoch; George B Spiegelman
The Bacillus subtilis response regulator Spo0A stimulates transcription of the spoIIG operon through modification of RNA polymerase promoter complexes.
Journal of molecular biology 1996;256(3):436-48.
1994: J K Grimsley; R B Tjalkens; Mark A Strauch; T H Bird; George B Spiegelman; Z Hostomsky; John M Whiteley; James A Hoch
Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis.
The Journal of biological chemistry 1994;269(24):16977-82.
1994: M Khosla; George B Spiegelman; Gerald Weeks; T W Sands; K J Virdy; David A Cotter
RasG protein accumulation occurs just prior to amoebae emergence during spore germination in Dictyostelium discoideum.
FEMS microbiology letters 1994;117(3):293-8.
1994: J Daniel; Jason Bush; James A Cardelli; George B Spiegelman; Gerald Weeks
Isolation of two novel ras genes in Dictyostelium discoideum; evidence for a complex, developmentally regulated ras gene subfamily.
Oncogene 1994;9(2):501-8.
1993: Jason Bush; K Franek; J Daniel; George B Spiegelman; Gerald Weeks; James A Cardelli
Cloning and characterization of five novel Dictyostelium discoideum rab-related genes.
Gene 1993;136(1-2):55-60.
1993: N J Clegg; Ian P Whitehead; J A Williams; George B Spiegelman; Thomas A Grigliatti
A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 1993;36(4):676-85.
1993: T H Bird; J K Grimsley; James A Hoch; George B Spiegelman
Phosphorylation of Spo0A activates its stimulation of in vitro transcription from the Bacillus subtilis spoIIG operon.
Molecular microbiology 1993;9(4):741-9.
1993: S R Wellington; George B Spiegelman
The kinetics of formation of complexes between Escherichia coli RNA polymerase and the rrnB P1 and P2 promoters of Bacillus subtilis. Effects of guanosine tetraphosphate on select steps of transcription initiation.
The Journal of biological chemistry 1993;268(10):7205-14.
1993: J Daniel; George B Spiegelman; Gerald Weeks
Characterization of a third ras gene, rasB, that is expressed throughout the growth and development of Dictyostelium discoideum.
Oncogene 1993;8(4):1041-7.
1993: P J Rebstein; Gerald Weeks; George B Spiegelman
Altered morphology of vegetative amoebae induced by increased expression of the Dictyostelium discoideum ras-related gene rap1.
Developmental genetics 1993;14(5):347-55.
1992: R Thiery; S Robbins; M Khosla; George B Spiegelman; Gerald Weeks
The effects of expression of an activated rasG mutation on the differentiation of Dictyostelium.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(10-11):1193-9.
1992: T Bird; D Burbulys; J J Wu; Mark A Strauch; James A Hoch; George B Spiegelman
The effect of supercoiling on the in vitro transcription of the spoIIA operon from Bacillus subtilis.
Biochimie 1992;74(7-8):627-34.
1992: S M Robbins; J G Williams; George B Spiegelman; Gerald Weeks
Cloning and characterization of the Dictyostelium discoideum rasG genomic sequences.
Biochimica et biophysica acta 1992;1130(1):85-9.
1991: S R Wellington; George B Spiegelman
Separation of Escherichia coli RNA polymerase sigma-70 holoenzyme from core enzyme on heparin-Sepharose columns.
Biochemical and biophysical research communications 1991;179(2):1107-14.
1991: Marta Perego; J J Wu; George B Spiegelman; James A Hoch
Mutational dissociation of the positive and negative regulatory properties of the Spo0A sporulation transcription factor of Bacillus subtilis.
Gene 1991;100():207-12.
1991: S M Robbins; M Khosla; R Thiery; Gerald Weeks; George B Spiegelman
Ras-related genes in Dictyostelium discoideum.
Developmental genetics 1991;12(1-2):147-53.
1990: S M Robbins; V V Suttorp; Gerald Weeks; George B Spiegelman
A ras-related gene from the lower eukaryote Dictyostelium that is highly conserved relative to the human rap genes.
Nucleic acids research 1990;18(17):5265-9.
1990: George B Spiegelman; B Van Hoy; Marta Perego; Jonathan Day; K Trach; James A Hoch
Structural alterations in the Bacillus subtilis Spo0A regulatory protein which suppress mutations at several spo0 loci.
Journal of bacteriology 1990;172(9):5011-9.
1990: M Khosla; S M Robbins; George B Spiegelman; Gerald Weeks
Regulation of DdrasG gene expression during Dictyostelium development.
Molecular and cellular biology 1990;10(3):918-22.
1990: Mark A Strauch; V Webb; George B Spiegelman; James A Hoch
The SpoOA protein of Bacillus subtilis is a repressor of the abrB gene.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1801-5.
1989: Mark A Strauch; George B Spiegelman; Marta Perego; W C Johnson; D Burbulys; James A Hoch
The transition state transcription regulator abrB of Bacillus subtilis is a DNA binding protein.
The EMBO journal 1989;8(5):1615-21.
1989: S M Robbins; J G Williams; K A Jermyn; George B Spiegelman; Gerald Weeks
Growing and developing Dictyostelium cells express different ras genes.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):938-42.
1989: F G Sajjadi; George B Spiegelman
The modulatory element TNNCT affects transcription of a Drosophila tRNA(Val)4 gene without affecting transcription complex stability.
Nucleic acids research 1989;17(2):755-66.
1988: R M Mackay; D Horvath; L Duncan; George B Spiegelman
Heterologous 5' flanking regions do not support in vitro template activity of a Drosophila melanogaster tRNA(Val3b) gene.
Nucleic acids research 1988;16(9):4137-53.
1988: D Horvath; George B Spiegelman
Sequences between the internal control regions of tRNAArg of Drosophila melanogaster influence stimulation of transcription of the 5' flanking DNA.
Nucleic acids research 1988;16(6):2585-99.
1987: K F Dobinson; George B Spiegelman
Effect of the delta subunit of Bacillus subtilis RNA polymerase on initiation of RNA synthesis at two bacteriophage phi 29 promoters.
Biochemistry 1987;26(25):8206-13.
1987: F G Sajjadi; George B Spiegelman
Modulation of a Drosophila melanogaster tRNA gene transcription in vitro by a sequence TNNCT in its 5' flank.
Gene 1987;60(1):13-9.
1985: K F Dobinson; George B Spiegelman
Nucleotide sequence and transcription of a bacteriophage 29 early promoter.
The Journal of biological chemistry 1985;260(10):5950-5.
1985: G R Greenberg; D St Louis; L Duncan; R C Miller; George B Spiegelman
Partial purification of stable transcription complexes with cloned tRNA genes of Drosophila melanogaster.
The Journal of biological chemistry 1985;260(10):6248-53.
1985: J Leung; W R Addison; A D Delaney; R M MacKay; R C Miller; George B Spiegelman; Thomas A Grigliatti; G M Tener
Drosophila melanogaster tRNAVal3b genes and their allogenes.
Gene 1985;34(2-3):207-17.
1982: E Leduc; M Hoekstra; George B Spiegelman
Relationship between synthesis of ribosomes and RNA polymerase in Bacillus subtilis.
Canadian journal of microbiology 1982;28(11):1280-8.
1982: V Webb; E Leduc; George B Spiegelman
Burst size of bacteriophage SP82 as a function of growth rate of its host Bacillus subtilis.
Canadian journal of microbiology 1982;28(11):1277-80.
1982: B Rajput; L Duncan; D DeMille; R C Miller; George B Spiegelman
Transcription of cloned transfer RNA genes from Drosophila melanogaster in a homologous cell-free extract.
Nucleic acids research 1982;10(20):6541-50.
1982: T M Larsen; R C Miller; George B Spiegelman; S Hayashi; G M Tener; Donald A R Sinclair; Thomas A Grigliatti
RNA-DNA hybridization analyses of tRNA-Val-3b in Drosophila melanogaster.
Molecular & general genetics : MGG 1982;185(3):390-6.