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Lauri Aaltonen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Jennings Juliet E; Georgitsi Marianthi; Holdaway Ian; Daly Adrian F; Tichomirowa Maria; Beckers Albert; Aaltonen Lauri A; Karhu Auli; Cameron Fergus J
Aggressive pituitary adenomas occurring in young patients in a large Polynesian kindred with a germline R271W mutation in the AIP gene.
Yuan Ziqiang; Shin Joongho; Wilson Andrew; Goel Sanjay; Ling Yi-He; Ahmed Naseem; Dopeso Higinio; Jhawer Minaxi; Nasser Shannon; Montagna Cristina; Fordyce Kenneth; Augenlicht Leonard H; Aaltonen Lauri A; Arango Diego; Weber Thomas K; Mariadason John M
An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.
Järvinen Heikki J; Renkonen-Sinisalo Laura; Aktán-Collán Katja; Peltomäki Päivi; Aaltonen Lauri A; Mecklin Jukka-Pekka
Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.

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All Publications

2009: Jennings Juliet E; Georgitsi Marianthi; Holdaway Ian; Daly Adrian F; Tichomirowa Maria; Beckers Albert; Aaltonen Lauri A; Karhu Auli; Cameron Fergus J
Aggressive pituitary adenomas occurring in young patients in a large Polynesian kindred with a germline R271W mutation in the AIP gene.
European journal of endocrinology / European Federation of Endocrine Societies 2009;161(5):799-804.
2009: Yuan Ziqiang; Shin Joongho; Wilson Andrew; Goel Sanjay; Ling Yi-He; Ahmed Naseem; Dopeso Higinio; Jhawer Minaxi; Nasser Shannon; Montagna Cristina; Fordyce Kenneth; Augenlicht Leonard H; Aaltonen Lauri A; Arango Diego; Weber Thomas K; Mariadason John M
An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.
Cancer research 2009;69(19):7811-8.
2009: Järvinen Heikki J; Renkonen-Sinisalo Laura; Aktán-Collán Katja; Peltomäki Päivi; Aaltonen Lauri A; Mecklin Jukka-Pekka
Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(28):4793-7.
2009: Tuupanen Sari; Turunen Mikko; Lehtonen Rainer; Hallikas Outi; Vanharanta Sakari; Kivioja Teemu; Björklund Mikael; Wei Gonghong; Yan Jian; Niittymäki Iina; Mecklin Jukka-Pekka; Järvinen Heikki; Ristimäki Ari; Di-Bernardo Mariachiara; East Phil; Carvajal-Carmona Luis; Houlston Richard S; Tomlinson Ian; Palin Kimmo; Ukkonen Esko; Karhu Auli; Taipale Jussi; Aaltonen Lauri A
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.
Nature genetics 2009;41(8):885-90.
2009: Koski Taru A; Lehtonen Heli J; Jee Kowan J; Ninomiya Shinsuke; Joosse Simon A; Vahteristo Pia; Kiuru Maija; Karhu Auli; Sammalkorpi Heli; Vanharanta Sakari; Lehtonen Rainer; Edgren Henrik; Nederlof Petra M; Hietala Marja; Aittomäki Kristiina; Herva Riitta; Knuutila Sakari; Aaltonen Lauri A; Launonen Virpi
Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer.
Genes, chromosomes & cancer 2009;48(7):544-51.
2009: Vierimaa O; Villablanca A; Alimov A; Georgitsi M; Raitila A; Vahteristo P; Larsson C; Ruokonen A; Eloranta E; Ebeling T M L; Ignatius J; Aaltonen L A; Leisti J; Salmela P I
Mutation analysis of MEN1, HRPT2, CASR, CDKN1B, and AIP genes in primary hyperparathyroidism patients with features of genetic predisposition.
Journal of endocrinological investigation 2009;32(6):512-8.
2009: Raitila A; Georgitsi M; Bonora E; Vargiolu M; Tuppurainen K; Mäkinen M J; Vierimaa O; Salmela P I; Launonen V; Vahteristo P; Aaltonen L A; Romeo G; Karhu A
Aryl hydrocarbon receptor interacting protein mutations seem not to associate with familial non-medullary thyroid cancer.
Journal of endocrinological investigation 2009;32(5):426-9.
2009: Melo Sonia A; Ropero Santiago; Moutinho Catia; Aaltonen Lauri A; Yamamoto Hiroyuki; Calin George A; Rossi Simona; Fernandez Agustin F; Carneiro Fatima; Oliveira Carla; Ferreira Bibiana; Liu Chang-Gong; Villanueva Alberto; Capella Gabriel; Schwartz Simo; Shiekhattar Ramin; Esteller Manel
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.
Nature genetics 2009;41(3):365-70.
2009: Raimundo N; Vanharanta S; Aaltonen L A; Hovatta I; Suomalainen A
Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas.
Oncogene 2009;28(9):1261-73.
2009: Andersen C L; Christensen L L; Thorsen K; Schepeler T; Sørensen F B; Verspaget H W; Simon R; Kruhøffer M; Aaltonen L A; Laurberg S; Ørntoft T F
Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer.
British journal of cancer 2009;100(3):511-23.
2008: Georgitsi Marianthi; Heliövaara Elina; Paschke Ralf; Kumar Ajith V K; Tischkowitz Marc; Vierimaa Outi; Salmela Pasi; Sane Timo; De Menis Ernesto; Cannavò Salvatore; Gündogdu Sadi; Lucassen Anneke; Izatt Louise; Aylwin Simon; Bano Gul; Hodgson Shirley; Koch Christian A; Karhu Auli; Aaltonen Lauri A
Large genomic deletions in AIP in pituitary adenoma predisposition.
The Journal of clinical endocrinology and metabolism 2008;93(10):4146-51.
2008: Georgitsi Marianthi; De Menis Ernesto; Cannavò Salvatore; Mäkinen Markus J; Tuppurainen Karoliina; Pauletto Paolo; Curtò Lorenzo; Weil Robert J; Paschke Ralf; Zielinski Grzegorz; Wasik Anna; Lubinski Jan; Vahteristo Pia; Karhu Auli; Aaltonen Lauri A
Aryl hydrocarbon receptor interacting protein (AIP) gene mutation analysis in children and adolescents with sporadic pituitary adenomas.
Clinical endocrinology 2008;69(4):621-7.
2008: Sammalkorpi Heli; Alhopuro Pia; Niittymäki Iina; Orntoft Torben F; Hokland Peter; Karhu Auli; Aaltonen Lauri A
Mutation analysis of MYH11 in acute myeloid leukemia.
Leukemia & lymphoma 2008;49(9):1829-31.
2008: Siltanen Sanna; Syrjäkoski Kirsi; Fagerholm Rainer; Ikonen Tarja; Lipman Peter; Mallott Jacob; Holli Kaija; Tammela Teuvo L J; Järvinen Heikki J; Mecklin Jukka-Pekka; Aittomäki Kristiina; Blomqvist Carl; Bailey-Wilson Joan E; Nevanlinna Heli; Aaltonen Lauri A; Schleutker Johanna; Vahteristo Pia
ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer.
European journal of human genetics : EJHG 2008;16(8):983-91.
2008: Ahvenainen Taru; Lehtonen Heli J; Lehtonen Rainer; Vahteristo Pia; Aittomäki Kristiina; Baynam Gareth; Dommering Charlotte; Eng Charis; Gruber Stephen B; Grönberg Henrik; Harvima Rauno; Herva Riitta; Hietala Marja; Kujala Minna; Kääriäinen Helena; Sunde Lone; Vierimaa Outi; Pollard Patrick J; Tomlinson Ian P M; Björck Erik; Aaltonen Lauri A; Launonen Virpi
Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer.
Cancer genetics and cytogenetics 2008;183(2):83-8.
2008: Petrova Tatiana V; Nykänen Antti; Norrmén Camilla; Ivanov Konstantin I; Andersson Leif C; Haglund Caj; Puolakkainen Pauli; Wempe Frank; von Melchner Harald; Gradwohl Gérard; Vanharanta Sakari; Aaltonen Lauri A; Saharinen Juha; Gentile Massimiliano; Clarke Alan; Taipale Jussi; Oliver Guillermo; Alitalo Kari
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.
Cancer cell 2008;13(5):407-19.
2008: Alhopuro Pia; Phichith Denis; Tuupanen Sari; Sammalkorpi Heli; Nybondas Miranda; Saharinen Juha; Robinson James P; Yang Zhaohui; Chen Li-Qiong; Orntoft Torben; Mecklin Jukka-Pekka; Järvinen Heikki; Eng Charis; Moeslein Gabriela; Shibata Darryl; Houlston Richard S; Lucassen Anneke; Tomlinson Ian P M; Launonen Virpi; Ristimäki Ari; Arango Diego; Karhu Auli; Sweeney H Lee; Aaltonen Lauri A
Unregulated smooth-muscle myosin in human intestinal neoplasia.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5513-8.
2008: Tuupanen Sari; Niittymäki Iina; Nousiainen Kari; Vanharanta Sakari; Mecklin Jukka-Pekka; Nuorva Kyösti; Järvinen Heikki; Hautaniemi Sampsa; Karhu Auli; Aaltonen Lauri A
Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.
Cancer research 2008;68(1):14-7.
2008: Alberici Paola; Gaspar Claudia; Franken Patrick; Gorski Marcin M; de Vries Ingrid; Scott Rodney J; Ristimäki Ari; Aaltonen Lauri A; Fodde Riccardo
Smad4 haploinsufficiency: a matter of dosage.
PathoGenetics 2008;1(1):2.
2008: Alhopuro Pia; Karhu Auli; Winqvist Robert; Waltering Kati; Visakorpi Tapio; Aaltonen Lauri A
Somatic mutation analysis of MYH11 in breast and prostate cancer.
BMC cancer 2008;8():263.
2007: Yang Qin; Zhang Ran; Horikawa Izumi; Fujita Kaori; Afshar Yalda; Kokko Antti; Laiho Päivi; Aaltonen Lauri A; Harris Curtis C
Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.
Cancer research 2007;67(24):11677-86.
2007: Vahteristo P; Kokko A; Saksela O; Aittomäki K; Aaltonen L A
Blood-derived gene-expression profiling in unravelling susceptibility to recessive disease.
Journal of medical genetics 2007;44(11):718-20.
2007: Aktan-Collan K; Haukkala A; Pylvänäinen K; Järvinen H J; Aaltonen L A; Peltomäki P; Rantanen E; Kääriäinen H; Mecklin J-P
Direct contact in inviting high-risk members of hereditary colon cancer families to genetic counselling and DNA testing.
Journal of medical genetics 2007;44(11):732-8.
2007: Mecklin Jukka-Pekka; Aarnio Markku; Läärä Esa; Kairaluoma Matti V; Pylvänäinen Kirsi; Peltomäki Päivi; Aaltonen Lauri A; Järvinen Heikki J
Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome.
Gastroenterology 2007;133(4):1093-8.
2007: Birkenkamp-Demtroder Karin; Mansilla Francisco; Sørensen Flemming Brandt; Kruhøffer Mogens; Cabezón Teresa; Christensen Lise Lotte; Aaltonen Lauri A; Verspaget Hein W; Ørntoft Torben Falck
Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro.
Molecular oncology 2007;1(2):181-95.
2007: Raitila A; Georgitsi M; Karhu A; Tuppurainen K; Mäkinen M J; Birkenkamp-Demtröder K; Salmenkivi K; Orntoft T F; Arola J; Launonen V; Vahteristo P; Aaltonen L A
No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.
Endocrine-related cancer 2007;14(3):901-6.
2007: Lehtonen Heli J; Mäkinen Markus J; Kiuru Maija; Laiho Päivi; Herva Riitta; van Minderhout Ivonne; Hogendoorn Pancras C W; Cornelisse Cees; Devilee Peter; Launonen Virpi; Aaltonen Lauri A
Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability.
International journal of cancer. Journal international du cancer 2007;121(6):1386-9.
2007: Georgitsi Marianthi; Raitila Anniina; Karhu Auli; van der Luijt Rob B; Aalfs Cora M; Sane Timo; Vierimaa Outi; Mäkinen Markus J; Tuppurainen Karoliina; Paschke Ralph; Gimm Oliver; Koch Christian A; Gündogdu Sadi; Lucassen Anneke; Tischkowitz Marc; Izatt Louise; Aylwin Simon; Bano Gul; Hodgson Shirley; De Menis Ernesto; Launonen Virpi; Vahteristo Pia; Aaltonen Lauri A
Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia.
The Journal of clinical endocrinology and metabolism 2007;92(8):3321-5.
2007: Laakso Marko; Tuupanen Sari; Karhu Auli; Lehtonen Rainer; Aaltonen Lauri A; Hautaniemi Sampsa
Computational identification of candidate loci for recessively inherited mutation using high-throughput SNP arrays.
Bioinformatics (Oxford, England) 2007;23(15):1952-61.
2007: Tuupanen Sari; Alhopuro Pia; Mecklin Jukka-Pekka; Järvinen Heikki; Aaltonen Lauri A
No evidence for association of NOD2 R702W and G908R with colorectal cancer.
International journal of cancer. Journal international du cancer 2007;121(1):76-9.
2007: Sammalkorpi Heli; Alhopuro Pia; Lehtonen Rainer; Tuimala Jarno; Mecklin Jukka-Pekka; Järvinen Heikki J; Jiricny Josef; Karhu Auli; Aaltonen Lauri A
Background mutation frequency in microsatellite-unstable colorectal cancer.
Cancer research 2007;67(12):5691-8.
2007: Mansilla F; Birkenkamp-Demtroder K; Kruhøffer M; Sørensen F B; Andersen C L; Laiho P; Aaltonen L A; Verspaget H W; Orntoft T F
Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups.
British journal of cancer 2007;96(12):1896-903.
2007: Andersen Claus Lindbjerg; Schepeler Troels; Thorsen Kasper; Birkenkamp-Demtröder Karin; Mansilla Francisco; Aaltonen Lauri A; Laurberg Søren; Ørntoft Torben Falck
Clusterin expression in normal mucosa and colorectal cancer.
Molecular & cellular proteomics : MCP 2007;6(6):1039-48.
2007: Vanharanta Sakari; Wortham Noel C; Langford Cordelia; El-Bahrawy Mona; van der Spuy Zephne; Sjöberg Jari; Lehtonen Rainer; Karhu Auli; Tomlinson Ian P M; Aaltonen Lauri A
Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region.
Genes, chromosomes & cancer 2007;46(5):451-8.
2007: Lehtonen Heli J; Blanco Ignacio; Piulats Jose M; Herva Riitta; Launonen Virpi; Aaltonen Lauri A
Conventional renal cancer in a patient with fumarate hydratase mutation.
Human pathology 2007;38(5):793-6.
2007: Karhu Auli; Aaltonen Lauri A
Susceptibility to pituitary neoplasia related to MEN-1, CDKN1B and AIP mutations: an update.
Human molecular genetics 2007;16 Spec No 1():R73-9.
2007: Tuupanen S; Karhu A; Järvinen H; Mecklin J P; Launonen V; Aaltonen L A
No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer.
Oncogene 2007;26(17):2513-7.
2007: Georgitsi Marianthi; Raitila Anniina; Karhu Auli; Tuppurainen Karoliina; Mäkinen Markus J; Vierimaa Outi; Paschke Ralf; Saeger Wolfgang; van der Luijt Rob B; Sane Timo; Robledo Mercedes; De Menis Ernesto; Weil Robert J; Wasik Anna; Zielinski Grzegorz; Lucewicz Olga; Lubinski Jan; Launonen Virpi; Vahteristo Pia; Aaltonen Lauri A
Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4101-5.
2007: Erkko Hannele; Xia Bing; Nikkilä Jenni; Schleutker Johanna; Syrjäkoski Kirsi; Mannermaa Arto; Kallioniemi Anne; Pylkäs Katri; Karppinen Sanna-Maria; Rapakko Katrin; Miron Alexander; Sheng Qing; Li Guilan; Mattila Henna; Bell Daphne W; Haber Daniel A; Grip Mervi; Reiman Mervi; Jukkola-Vuorinen Arja; Mustonen Aki; Kere Juha; Aaltonen Lauri A; Kosma Veli-Matti; Kataja Vesa; Soini Ylermi; Drapkin Ronny I; Livingston David M; Winqvist Robert
A recurrent mutation in PALB2 in Finnish cancer families.
Nature 2007;446(7133):316-9.
2007: Georgitsi M; Karhu A; Winqvist R; Visakorpi T; Waltering K; Vahteristo P; Launonen V; Aaltonen L A
Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers.
British journal of cancer 2007;96(2):352-6.
2007: Alazzouzi Hafid; Suriano Gianpaolo; Guerra Angel; Plaja Alberto; Espín Eloi; Armengol Manel; Alhopuro Pia; Velho Sergia; Shinomura Yasuhisa; González-Aguilera Juan José; Yamamoto Hiroyuki; Aaltonen Lauri A; Moreno Víctor; Capellà Gabriel; Peinado Miguel Angel; Seruca Raquel; Arango Diego; Schwartz Simó
Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells.
Journal of medical genetics 2007;44(1):75-80.
2007: Laiho P; Kokko A; Vanharanta S; Salovaara R; Sammalkorpi H; Järvinen H; Mecklin J-P; Karttunen T J; Tuppurainen K; Davalos V; Schwartz S; Arango D; Mäkinen M J; Aaltonen L A
Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis.
Oncogene 2007;26(2):312-20.
2007: Lehtonen Heli J; Ylisaukko-Oja Sanna K; Kiuru Maija; Karhu Auli; Lehtonen Rainer; Vanharanta Sakari; Jalanko Anu; Aaltonen Lauri A; Launonen Virpi
Stress-induced expression of a novel variant of human fumarate hydratase (FH).
Gene expression 2007;14(2):59-69.
2007: Aaltonen Lauri A
Aryl hydrocarbon receptor-interacting protein and acromegaly.
Hormone research 2007;68 Suppl 5():127-31.
2006: Bond Gareth L; Menin Chiara; Bertorelle Roberta; Alhopuro Pia; Aaltonen Lauri A; Levine Arnold J
MDM2 SNP309 accelerates colorectal tumour formation in women.
Journal of medical genetics 2006;43(12):950-2.
2006: Karppinen S-M; Barkardottir R B; Backenhorn K; Sydenham T; Syrjäkoski K; Schleutker J; Ikonen T; Pylkäs K; Rapakko K; Erkko H; Johannesdottir G; Gerdes A-M; Thomassen M; Agnarsson B A; Grip M; Kallioniemi A; Kere J; Aaltonen L A; Arason A; Møller P; Kruse T A; Borg A; Winqvist R
Nordic collaborative study of the BARD1 Cys557Ser allele in 3956 patients with cancer: enrichment in familial BRCA1/BRCA2 mutation-negative breast cancer but not in other malignancies.
Journal of medical genetics 2006;43(11):856-62.
2006: Davalos Veronica; Dopeso Higinio; Castaño Julio; Wilson Andrew J; Vilardell Felip; Romero-Gimenez Jordi; Espín Eloy; Armengol Manel; Capella Gabriel; Mariadason John M; Aaltonen Lauri A; Schwartz Simo; Arango Diego
EPHB4 and survival of colorectal cancer patients.
Cancer research 2006;66(18):8943-8.
2006: Kilpivaara O; Alhopuro P; Vahteristo P; Aaltonen L A; Nevanlinna H
CHEK2 I157T associates with familial and sporadic colorectal cancer.
Journal of medical genetics 2006;43(7):e34.
2006: Ylisaukko-oja Sanna K; Cybulski Cezary; Lehtonen Rainer; Kiuru Maija; Matyjasik Joanna; Szymañska Anna; Szymañska-Pasternak Jolanta; Dyrskjot Lars; Butzow Ralf; Orntoft Torben F; Launonen Virpi; Lubiñski Jan; Aaltonen Lauri A
Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma.
European journal of human genetics : EJHG 2006;14(7):880-3.
2006: Ylisaukko-oja Sanna K; Kiuru Maija; Lehtonen Heli J; Lehtonen Rainer; Pukkala Eero; Arola Johanna; Launonen Virpi; Aaltonen Lauri A
Analysis of fumarate hydratase mutations in a population-based series of early onset uterine leiomyosarcoma patients.
International journal of cancer. Journal international du cancer 2006;119(2):283-7.
2006: Lehtonen H J; Kiuru M; Ylisaukko-Oja S K; Salovaara R; Herva R; Koivisto P A; Vierimaa O; Aittomäki K; Pukkala E; Launonen V; Aaltonen L A
Increased risk of cancer in patients with fumarate hydratase germline mutation.
Journal of medical genetics 2006;43(6):523-6.
2006: Vierimaa Outi; Georgitsi Marianthi; Lehtonen Rainer; Vahteristo Pia; Kokko Antti; Raitila Anniina; Tuppurainen Karoliina; Ebeling Tapani M L; Salmela Pasi I; Paschke Ralf; Gündogdu Sadi; De Menis Ernesto; Mäkinen Markus J; Launonen Virpi; Karhu Auli; Aaltonen Lauri A
Pituitary adenoma predisposition caused by germline mutations in the AIP gene.
Science (New York, N.Y.) 2006;312(5777):1228-30.
2006: Volikos E; Robinson J; Aittomäki K; Mecklin J-P; Järvinen H; Westerman A M; de Rooji F W M; Vogel T; Moeslein G; Launonen V; Tomlinson I P M; Silver A R J; Aaltonen L A
LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome.
Journal of medical genetics 2006;43(5):e18.
2006: Ropero Santiago; Fraga Mario F; Ballestar Esteban; Hamelin Richard; Yamamoto Hiroyuki; Boix-Chornet Manuel; Caballero Rosalia; Alaminos Miguel; Setien Fernando; Paz Maria F; Herranz Michel; Palacios Jose; Arango Diego; Orntoft Torben F; Aaltonen Lauri A; Schwartz Simó; Esteller Manel
A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition.
Nature genetics 2006;38(5):566-9.
2006: Kokko Antti; Ylisaukko-Oja Sanna S K; Kiuru Maija; Takatalo Maarit S; Salmikangas Paula; Tuimala Jarno; Arango Diego; Karhu Auli; Aaltonen Lauri A; Jäntti Jussi
Modeling tumor predisposing FH mutations in yeast: effects on fumarase activity, growth phenotype and gene expression profile.
International journal of cancer. Journal international du cancer 2006;118(6):1340-5.
2006: Vanharanta Sakari; Pollard Patrick J; Lehtonen Heli J; Laiho Päivi; Sjöberg Jari; Leminen Arto; Aittomäki Kristiina; Arola Johanna; Kruhoffer Mogens; Orntoft Torben F; Tomlinson Ian P; Kiuru Maija; Arango Diego; Aaltonen Lauri A
Distinct expression profile in fumarate-hydratase-deficient uterine fibroids.
Human molecular genetics 2006;15(1):97-103.
2006: Hienonen Tuija; Salovaara Reijo; Mecklin Jukka-Pekka; Järvinen Heikki; Karhu Auli; Aaltonen Lauri A
Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers.
International journal of cancer. Journal international du cancer 2006;118(2):505-8.
2006: Aaltonen Lauri A
[Not Available]
Duodecim; lääketieteellinen aikakauskirja 2006;122(18):2221-30.
2006: Kokko Antti; Laiho Päivi; Lehtonen Rainer; Korja Sanna; Carvajal-Carmona Luis G; Järvinen Heikki; Mecklin Jukka-Pekka; Eng Charis; Schleutker Johanna; Tomlinson Ian P M; Vahteristo Pia; Aaltonen Lauri A
EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis.
BMC cancer 2006;6():145.
2005: Alazzouzi Hafid; Davalos Veronica; Kokko Antti; Domingo Enric; Woerner Stefan M; Wilson Andrew J; Konrad Lars; Laiho Päivi; Espín Eloi; Armengol Manel; Imai Kohzoh; Yamamoto Hiroyuki; Mariadason John M; Gebert Johannes F; Aaltonen Lauri A; Schwartz Simo; Arango Diego
Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.
Cancer research 2005;65(22):10170-3.
2005: Sweet Kevin; Willis Joseph; Zhou Xiao-Ping; Gallione Carol; Sawada Takeshi; Alhopuro Pia; Khoo Sok Kean; Patocs Attila; Martin Cossette; Bridgeman Scott; Heinz John; Pilarski Robert; Lehtonen Rainer; Prior Thomas W; Frebourg Thierry; Teh Bin Tean; Marchuk Douglas A; Aaltonen Lauri A; Eng Charis
Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis.
JAMA : the journal of the American Medical Association 2005;294(19):2465-73.
2005: Sotamaa Kaisa; Liyanarachchi Sandya; Mecklin Jukka-Pekka; Järvinen Heikki; Aaltonen Lauri A; Peltomäki Päivi; de la Chapelle Albert
p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):6840-4.
2005: Alhopuro Pia; Parker Antony R; Lehtonen Rainer; Enholm Susa; Järvinen Heikki J; Mecklin Jukka-Pekka; Karhu Auli; Eshleman James R; Aaltonen Lauri A
A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis.
Human mutation 2005;26(4):393.
2005: Alhopuro Pia; Alazzouzi Hafid; Sammalkorpi Heli; Dávalos Verónica; Salovaara Reijo; Hemminki Akseli; Järvinen Heikki; Mecklin Jukka-Pekka; Schwartz Simo; Aaltonen Lauri A; Arango Diego
SMAD4 levels and response to 5-fluorouracil in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6311-6.
2005: Arango Diego; Laiho Paivi; Kokko Antti; Alhopuro Pia; Sammalkorpi Heli; Salovaara Reijo; Nicorici Daniel; Hautaniemi Sampsa; Alazzouzi Hafid; Mecklin Jukka-Pekka; Järvinen Heikki; Hemminki Akseli; Astola Jaakko; Schwartz Simo; Aaltonen Lauri A
Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer.
Gastroenterology 2005;129(3):874-84.
2005: Alhopuro P; Ylisaukko-Oja S K; Koskinen W J; Bono P; Arola J; Järvinen H J; Mecklin J-P; Atula T; Kontio R; Mäkitie A A; Suominen S; Leivo I; Vahteristo P; Aaltonen L-M; Aaltonen L A
The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck.
Journal of medical genetics 2005;42(9):694-8.
2005: Vanharanta Sakari; Wortham Noel C; Laiho Päivi; Sjöberg Jari; Aittomäki Kristiina; Arola Johanna; Tomlinson Ian P; Karhu Auli; Arango Diego; Aaltonen Lauri A
7q deletion mapping and expression profiling in uterine fibroids.
Oncogene 2005;24(43):6545-54.
2005: Hampel Heather; Stephens Julie A; Pukkala Eero; Sankila Risto; Aaltonen Lauri A; Mecklin Jukka-Pekka; de la Chapelle Albert
Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset.
Gastroenterology 2005;129(2):415-21.
2005: Kruhøffer M; Jensen J L; Laiho P; Dyrskjøt L; Salovaara R; Arango D; Birkenkamp-Demtroder K; Sørensen F B; Christensen L L; Buhl L; Mecklin J-P; Järvinen H; Thykjaer T; Wikman F P; Bech-Knudsen F; Juhola M; Nupponen N N; Laurberg S; Andersen C L; Aaltonen L A; Ørntoft T F
Gene expression signatures for colorectal cancer microsatellite status and HNPCC.
British journal of cancer 2005;92(12):2240-8.
2005: Hienonen Tuija; Sammalkorpi Heli; Enholm Susa; Alhopuro Pia; Barber Thomas D; Lehtonen Rainer; Nupponen Nina N; Lehtonen Heli; Salovaara Reijo; Mecklin Jukka-Pekka; Järvinen Heikki; Koistinen Riitta; Arango Diego; Launonen Virpi; Vogelstein Bert; Karhu Auli; Aaltonen Lauri A
Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers.
Cancer research 2005;65(11):4607-13.
2005: Domingo Enric; Niessen Renée C; Oliveira Carla; Alhopuro Pia; Moutinho Catia; Espín Eloi; Armengol Manel; Sijmons Rolf H; Kleibeuker Jan H; Seruca Raquel; Aaltonen Lauri A; Imai Kohzoh; Yamamoto Hiroyuki; Schwartz Simó; Hofstra Robert M W
BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes.
Oncogene 2005;24(24):3995-8.
2005: Rasinperä H; Forsblom C; Enattah N S; Halonen P; Salo K; Victorzon M; Mecklin J-P; Järvinen H; Enholm S; Sellick G; Alazzouzi H; Houlston R; Robinson J; Groop P-H; Tomlinson I; Schwartz S; Aaltonen L A; Järvelä I;
The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population.
Gut 2005;54(5):643-7.
2005: Alazzouzi Hafid; Alhopuro Pia; Salovaara Reijo; Sammalkorpi Heli; Järvinen Heikki; Mecklin Jukka-Pekka; Hemminki Akeseli; Schwartz Simo; Aaltonen Lauri A; Arango Diego
SMAD4 as a prognostic marker in colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2606-11.
2005: Vahteristo P; Ojala S; Tamminen A; Tommiska J; Sammalkorpi H; Kiuru-Kuhlefelt S; Eerola H; Aaltonen L A; Aittomäki K; Nevanlinna H
No MSH6 germline mutations in breast cancer families with colorectal and/or endometrial cancer.
Journal of medical genetics 2005;42(4):e22.
2005: Kiuru Maija; Lehtonen Rainer; Eerola Hannaleena; Aittomäki Kristiina; Blomqvist Carl; Nevanlinna Heli; Aaltonen Lauri A; Launonen Virpi
No germline FH mutations in familial breast cancer patients.
European journal of human genetics : EJHG 2005;13(4):506-9.
2005: Alhopuro P; Katajisto P; Lehtonen R; Ylisaukko-Oja S K; Näätsaari L; Karhu A; Westerman A M; Wilson J H P; de Rooij F W M; Vogel T; Moeslein G; Tomlinson I P; Aaltonen L A; Mäkelä T P; Launonen V
Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.
British journal of cancer 2005;92(6):1126-9.
2005: Birkenkamp-Demtroder K; Olesen S H; Sørensen F B; Laurberg S; Laiho P; Aaltonen L A; Orntoft T F
Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid.
Gut 2005;54(3):374-84.
2005: Hienonen T; Sammalkorpi H; Isohanni P; Versteeg R; Karikoski R; Aaltonen L A
A 17p11.2 germline deletion in a patient with Smith-Magenis syndrome and neuroblastoma.
Journal of medical genetics 2005;42(1):e3.
2005: Calabrese Peter; Mecklin Jukka-Pekka; Järvinen Heikki J; Aaltonen Lauri A; Tavaré Simon; Shibata Darryl
Numbers of mutations to different types of colorectal cancer.
BMC cancer 2005;5():126.
2004: Alhopuro Pia; Ahvenainen Taru; Mecklin Jukka-Pekka; Juhola Matti; Järvinen Heikki J; Karhu Auli; Aaltonen Lauri A
NOD2 3020insC alone is not sufficient for colorectal cancer predisposition.
Cancer research 2004;64(20):7245-7.
2004: Oliveira Carla; Westra Jantine L; Arango Diego; Ollikainen Miina; Domingo Enric; Ferreira Ana; Velho Sérgia; Niessen Renee; Lagerstedt Kristina; Alhopuro Pia; Laiho Paivi; Veiga Isabel; Teixeira Manuel R; Ligtenberg Marjolijn; Kleibeuker Jan H; Sijmons Rolf H; Plukker John T; Imai Kohzoh; Lage Pedro; Hamelin Richard; Albuquerque Cristina; Schwartz Simo; Lindblom Annika; Peltomaki Päivi; Yamamoto Hiroyuki; Aaltonen Lauri A; Seruca Raquel; Hofstra Robert M W
Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status.
Human molecular genetics 2004;13(19):2303-11.
2004: Domingo E; Laiho P; Ollikainen M; Pinto M; Wang L; French A J; Westra J; Frebourg T; Espín E; Armengol M; Hamelin R; Yamamoto H; Hofstra R M W; Seruca R; Lindblom A; Peltomäki P; Thibodeau S N; Aaltonen L A; Schwartz S
BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing.
Journal of medical genetics 2004;41(9):664-8.
2004: Howe J R; Sayed M G; Ahmed A F; Ringold J; Larsen-Haidle J; Merg A; Mitros F A; Vaccaro C A; Petersen G M; Giardiello F M; Tinley S T; Aaltonen L A; Lynch H T
The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations.
Journal of medical genetics 2004;41(7):484-91.
2004: Calabrese Peter; Tsao Jen-Lan; Yatabe Yasushi; Salovaara Reijo; Mecklin Jukka-Pekka; Järvinen Heikki J; Aaltonen Lauri A; Tavaré Simon; Shibata Darryl
Colorectal pretumor progression before and after loss of DNA mismatch repair.
The American journal of pathology 2004;164(4):1447-53.
2004: Lehtonen Rainer; Kiuru Maija; Vanharanta Sakari; Sjöberg Jari; Aaltonen Leena-Maija; Aittomäki Kristiina; Arola Johanna; Butzow Ralf; Eng Charis; Husgafvel-Pursiainen Kirsti; Isola Jorma; Järvinen Heikki; Koivisto Pasi; Mecklin Jukka-Pekka; Peltomäki Päivi; Salovaara Reijo; Wasenius Veli-Matti; Karhu Auli; Launonen Virpi; Nupponen Nina N; Aaltonen Lauri A
Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors.
The American journal of pathology 2004;164(1):17-22.
2004: Vanharanta Sakari; Buchta Mary; McWhinney Sarah R; Virta Sanna K; Peçzkowska Mariola; Morrison Carl D; Lehtonen Rainer; Januszewicz Andrzej; Järvinen Heikki; Juhola Matti; Mecklin Jukka-Pekka; Pukkala Eero; Herva Riitta; Kiuru Maija; Nupponen Nina N; Aaltonen Lauri A; Neumann Hartmut P H; Eng Charis
Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma.
American journal of human genetics 2004;74(1):153-9.
2003: Alam N A; Gorman P; Jaeger E E M; Kelsell D; Leigh I M; Ratnavel R; Murdoch M E; Houlston R S; Aaltonen L A; Roylance R R; Tomlinson I P M
Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.
Cancer genetics and cytogenetics 2003;147(2):121-7.
2003: Lipton Lara; Halford Sarah E; Johnson Victoria; Novelli Marco R; Jones Angela; Cummings Carole; Barclay Ella; Sieber Oliver; Sadat Amir; Bisgaard Marie-Luise; Hodgson Shirley V; Aaltonen Lauri A; Thomas Huw J W; Tomlinson Ian P M
Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway.
Cancer research 2003;63(22):7595-9.
2003: Kilpivaara O; Laiho P; Aaltonen L A; Nevanlinna H
CHEK2 1100delC and colorectal cancer.
Journal of medical genetics 2003;40(10):e110.
2003: Enholm Susa; Hienonen Tuija; Suomalainen Anu; Lipton Lara; Tomlinson Ian; Kärjä Vesa; Eskelinen Matti; Mecklin Jukka-Pekka; Karhu Auli; Järvinen Heikki J; Aaltonen Lauri A
Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients.
The American journal of pathology 2003;163(3):827-32.
2003: Hienonen Tuija; Laiho Päivi; Salovaara Reijo; Mecklin Jukka-Pekka; Järvinen Heikki; Sistonen Pertti; Peltomäki Päivi; Lehtonen Rainer; Nupponen Nina N; Launonen Virpi; Karhu Auli; Aaltonen Lauri A
Little evidence for involvement of MLH3 in colorectal cancer predisposition.
International journal of cancer. Journal international du cancer 2003;106(2):292-6.
2003: Laiho P; Hienonen T; Mecklin J-P; Järvinen H; Karhu A; Launonen V; Aaltonen L A
Mutation and LOH analysis of ACO2 in colorectal cancer: no evidence of biallelic genetic inactivation.
Journal of medical genetics 2003;40(5):e73.
2003: Laiho Päivi; Hienonen Tuija; Karhu Auli; Lipton Lara; Aalto Yan; Thomas Huw J W; Birkenkamp-Demtroder Karin; Hodgson Shirley; Salovaara Reijo; Mecklin Jukka-Pekka; Järvinen Heikki; Knuutila Sakari; Halford Sarah; Ørntoft Torben F; Tomlinson Ian; Launonen Virpi; Houlston Richard; Aaltonen Lauri A
Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases.
Oncogene 2003;22(14):2206-14.
2003: Lehtonen R; Kiuru M; Rökman A; Ikonen T; Cunningham J M; Schaid D J; Matikainen M; Nupponen N N; Karhu A; Kallioniemi O-P; Thibodeau S N; Schleutker J; Aaltonen L A
No fumarate hydratase (FH) mutations in hereditary prostate cancer.
Journal of medical genetics 2003;40(3):e19.
2003: Eng Charis; Kiuru Maija; Fernandez Magali J; Aaltonen Lauri A
A role for mitochondrial enzymes in inherited neoplasia and beyond.
Nature reviews. Cancer 2003;3(3):193-202.
2003: Sieber Oliver M; Lipton Lara; Crabtree Michael; Heinimann Karl; Fidalgo Paulo; Phillips Robin K S; Bisgaard Marie-Luise; Orntoft Torben F; Aaltonen Lauri A; Hodgson Shirley V; Thomas Huw J W; Tomlinson Ian P M
Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.
The New England journal of medicine 2003;348(9):791-9.
2003: Jagmohan-Changur Shantie; Poikonen Taija; Vilkki Susa; Launonen Virpi; Wikman Friedrik; Orntoft Torben F; Møller Pål; Vasen Hans; Tops Carli; Kolodner Richard D; Mecklin Jukka-Pekka; Järvinen Heikki; Bevan Stephen; Houlston Richard S; Aaltonen Lauri A; Fodde Riccardo; Wijnen Juul; Karhu Auli
EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer.
Cancer research 2003;63(1):154-8.
2002: Vilkki S; Launonen V; Karhu A; Sistonen P; Västrik I; Aaltonen L A
Screening for microsatellite instability target genes in colorectal cancers.
Journal of medical genetics 2002;39(11):785-9.
2002: Rossi Derrick J; Ylikorkala Antti; Korsisaari Nina; Salovaara Reijo; Luukko Keijo; Launonen Virpi; Henkemeyer Mark; Ristimaki Ari; Aaltonen Lauri A; Makela Tomi P
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12327-32.
2002: Kiuru Maija; Lehtonen Rainer; Arola Johanna; Salovaara Reijo; Järvinen Heikki; Aittomäki Kristiina; Sjöberg Jari; Visakorpi Tapio; Knuutila Sakari; Isola Jorma; Delahunt Brett; Herva Riitta; Launonen Virpi; Karhu Auli; Aaltonen Lauri A
Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families.
Cancer research 2002;62(16):4554-7.
2002: Zhou Xiao-Ping; Loukola Anu; Salovaara Reijo; Nystrom-Lahti Minna; Peltomäki Päivi; de la Chapelle Albert; Aaltonen Lauri A; Eng Charis
PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers.
The American journal of pathology 2002;161(2):439-47.
2002: Birkenkamp-Demtroder Karin; Christensen Lise Lotte; Olesen Sanne Harder; Frederiksen Casper M; Laiho Päivi; Aaltonen Lauri A; Laurberg Søren; Sørensen Flemming B; Hagemann Rikke; ØRntoft Torben F
Gene expression in colorectal cancer.
Cancer research 2002;62(15):4352-63.
2002: Salovaara R; Roth S; Loukola A; Launonen V; Sistonen P; Avizienyte E; Kristo P; Järvinen H; Souchelnytskyi S; Sarlomo-Rikala M; Aaltonen L A
Frequent loss of SMAD4/DPC4 protein in colorectal cancers.
Gut 2002;51(1):56-9.
2002: Renkonen-Sinisalo L; Sipponen P; Aarnio M; Julkunen R; Aaltonen L A; Sarna S; Järvinen H J; Mecklin J P
No support for endoscopic surveillance for gastric cancer in hereditary non-polyposis colorectal cancer.
Scandinavian journal of gastroenterology 2002;37(5):574-7.
2002: Howe James R; Shellnut Jason; Wagner Brian; Ringold John C; Sayed Mohamed G; Ahmed Abul F; Lynch Patrick M; Amos Christopher I; Sistonen Pertti; Aaltonen Lauri A
Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot.
American journal of human genetics 2002;70(5):1357-62.
2002: Kim Kyoung-Mee; Salovaara Reijo; Mecklin Jukka-Pekka; Järvinen Heikki J; Aaltonen Lauri A; Shibata Darryl
PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper.
The American journal of pathology 2002;160(4):1503-6.
2002: Laiho Päivi; Launonen Virpi; Lahermo Päivi; Esteller Manel; Guo Mingzhou; Herman James G; Mecklin Jukka-Pekka; Järvinen Heikki; Sistonen Pertti; Kim Kyoung-Mee; Shibata Darryl; Houlston Richard S; Aaltonen Lauri A
Low-level microsatellite instability in most colorectal carcinomas.
Cancer research 2002;62(4):1166-70.
2001: Nakagawa H; Nuovo G J; Zervos E E; Martin E W; Salovaara R; Aaltonen L A; de la Chapelle A
Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development.
Cancer research 2001;61(19):6991-5.
2001: Woodford-Richens K L; Rowan A J; Poulsom R; Bevan S; Salovaara R; Aaltonen L A; Houlston R S; Wright N A; Tomlinson I P
Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers.
The American journal of pathology 2001;159(4):1293-300.
2001: Zhou X P; Woodford-Richens K; Lehtonen R; Kurose K; Aldred M; Hampel H; Launonen V; Virta S; Pilarski R; Salovaara R; Bodmer W F; Conrad B A; Dunlop M; Hodgson S V; Iwama T; Järvinen H; Kellokumpu I; Kim J C; Leggett B; Markie D; Mecklin J P; Neale K; Phillips R; Piris J; Rozen P; Houlston R S; Aaltonen L A; Tomlinson I P; Eng C
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes.
American journal of human genetics 2001;69(4):704-11.
2001: Kiuru M; Launonen V; Hietala M; Aittomäki K; Vierimaa O; Salovaara R; Arola J; Pukkala E; Sistonen P; Herva R; Aaltonen L A
Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology.
The American journal of pathology 2001;159(3):825-9.
2001: Vahteristo P; Tamminen A; Karvinen P; Eerola H; Eklund C; Aaltonen L A; Blomqvist C; Aittomäki K; Nevanlinna H
p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: further evidence of CHK2 in inherited cancer predisposition.
Cancer research 2001;61(15):5718-22.
2001: Lassus H; Salovaara R; Aaltonen L A; Butzow R
Allelic analysis of serous ovarian carcinoma reveals two putative tumor suppressor loci at 18q22-q23 distal to SMAD4, SMAD2, and DCC.
The American journal of pathology 2001;159(1):35-42.
2001: Loukola A; Eklin K; Laiho P; Salovaara R; Kristo P; Järvinen H; Mecklin J P; Launonen V; Aaltonen L A
Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC).
Cancer research 2001;61(11):4545-9.
2001: Vilkki S; Tsao J L; Loukola A; Pöyhönen M; Vierimaa O; Herva R; Aaltonen L A; Shibata D
Extensive somatic microsatellite mutations in normal human tissue.
Cancer research 2001;61(11):4541-4.
2001: Woodford-Richens K L; Halford S; Rowan A; Bevan S; Aaltonen L A; Wasan H; Bicknell D; Bodmer W F; Houlston R S; Tomlinson I P
CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers.
British journal of cancer 2001;84(10):1314-6.
2001: Lassus H; Laitinen M P; Anttonen M; Heikinheimo M; Aaltonen L A; Ritvos O; Butzow R
Comparison of serous and mucinous ovarian carcinomas: distinct pattern of allelic loss at distal 8p and expression of transcription factor GATA-4.
Laboratory investigation; a journal of technical methods and pathology 2001;81(4):517-26.
2001: Launonen V; Vierimaa O; Kiuru M; Isola J; Roth S; Pukkala E; Sistonen P; Herva R; Aaltonen L A
Inherited susceptibility to uterine leiomyomas and renal cell cancer.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3387-92.
2001: Avizienyte E; Launonen V; Salovaara R; Kiviluoto T; Aaltonen L A
E-cadherin is not frequently mutated in hereditary gastric cancer.
Journal of medical genetics 2001;38(1):49-52.
2001: Shibata D; Aaltonen L A
Genetic predisposition and somatic diversification in tumor development and progression.
Advances in cancer research 2001;80():83-114.
2000: Hemminki A; Mecklin J P; Järvinen H; Aaltonen L A; Joensuu H
Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy.
Gastroenterology 2000;119(4):921-8.
2000: Roth S; Laiho P; Salovaara R; Launonen V; Aaltonen L A
No SMAD4 hypermethylation in colorectal cancer.
British journal of cancer 2000;83(8):1015-9.
2000: Aaltonen L A
Hereditary intestinal cancer.
Seminars in cancer biology 2000;10(4):289-98.
2000: Loukola A; Vilkki S; Singh J; Launonen V; Aaltonen L A
Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer.
The American journal of pathology 2000;157(2):347-52.
2000: Salovaara R; Loukola A; Kristo P; Kääriäinen H; Ahtola H; Eskelinen M; Härkönen N; Julkunen R; Kangas E; Ojala S; Tulikoura J; Valkamo E; Järvinen H; Mecklin J P; Aaltonen L A; de la Chapelle A
Population-based molecular detection of hereditary nonpolyposis colorectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(11):2193-200.
2000: Järvinen H J; Aarnio M; Mustonen H; Aktan-Collan K; Aaltonen L A; Peltomäki P; De La Chapelle A; Mecklin J P
Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer.
Gastroenterology 2000;118(5):829-34.
2000: Roth S; Johansson M; Loukola A; Peltomäki P; Järvinen H; Mecklin J P; Aaltonen L A
Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal.
Journal of medical genetics 2000;37(4):298-300.
2000: Launonen V; Avizienyte E; Loukola A; Laiho P; Salovaara R; Järvinen H; Mecklin J P; Oku A; Shimane M; Kim H C; Kim J C; Nezu J; Aaltonen L A
No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas.
Cancer research 2000;60(3):546-8.
2000: Tsao J L; Yatabe Y; Salovaara R; Järvinen H J; Mecklin J P; Aaltonen L A; Tavaré S; Shibata D
Genetic reconstruction of individual colorectal tumor histories.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1236-41.
2000: Esteller M; Avizienyte E; Corn P G; Lothe R A; Baylin S B; Aaltonen L A; Herman J G
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome.
Oncogene 2000;19(1):164-8.
1999: Loukola A; Salovaara R; Kristo P; Moisio A L; Kääriäinen H; Ahtola H; Eskelinen M; Härkönen N; Julkunen R; Kangas E; Ojala S; Tulikoura J; Valkamo E; Järvinen H; Mecklin J P; de la Chapelle A; Aaltonen L A
Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer.
The American journal of pathology 1999;155(6):1849-53.
1999: Riccio A; Aaltonen L A; Godwin A K; Loukola A; Percesepe A; Salovaara R; Masciullo V; Genuardi M; Paravatou-Petsotas M; Bassi D E; Ruggeri B A; Klein-Szanto A J; Testa J R; Neri G; Bellacosa A
The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability.
Nature genetics 1999;23(3):266-8.
1999: Loukola A; de la Chapelle A; Aaltonen L A
Strategies for screening for hereditary non-polyposis colorectal cancer.
Journal of medical genetics 1999;36(11):819-22.
1999: Kuismanen S A; Holmberg M T; Salovaara R; Schweizer P; Aaltonen L A; de La Chapelle A; Nyström-Lahti M; Peltomäki P
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12661-6.
1999: Roth S; Sistonen P; Salovaara R; Hemminki A; Loukola A; Johansson M; Avizienyte E; Cleary K A; Lynch P; Amos C I; Kristo P; Mecklin J P; Kellokumpu I; Järvinen H; Aaltonen L A
SMAD genes in juvenile polyposis.
Genes, chromosomes & cancer 1999;26(1):54-61.
1999: Wolf M; Tarkkanen M; Hulsebos T; Larramendy M L; Forus A; Myklebost O; Aaltonen L A; Elomaa I; Knuutila S
Characterization of the 17p amplicon in human sarcomas: microsatellite marker analysis.
International journal of cancer. Journal international du cancer 1999;82(3):329-33.
1999: Tsao J L; Tavaré S; Salovaara R; Jass J R; Aaltonen L A; Shibata D
Colorectal adenoma and cancer divergence. Evidence of multilineage progression.
The American journal of pathology 1999;154(6):1815-24.
1999: Wang Z J; Churchman M; Avizienyte E; McKeown C; Davies S; Evans D G; Ferguson A; Ellis I; Xu W H; Yan Z Y; Aaltonen L A; Tomlinson I P
Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients.
Journal of medical genetics 1999;36(5):365-8.
1999: Aarnio M; Sankila R; Pukkala E; Salovaara R; Aaltonen L A; de la Chapelle A; Peltomäki P; Mecklin J P; Järvinen H J
Cancer risk in mutation carriers of DNA-mismatch-repair genes.
International journal of cancer. Journal international du cancer 1999;81(2):214-8.
1999: Avizienyte E; Loukola A; Roth S; Hemminki A; Tarkkanen M; Salovaara R; Arola J; Bützow R; Husgafvel-Pursiainen K; Kokkola A; Järvinen H; Aaltonen L A
LKB1 somatic mutations in sporadic tumors.
The American journal of pathology 1999;154(3):677-81.
1999: Ylikorkala A; Avizienyte E; Tomlinson I P; Tiainen M; Roth S; Loukola A; Hemminki A; Johansson M; Sistonen P; Markie D; Neale K; Phillips R; Zauber P; Twama T; Sampson J; Järvinen H; Mäkelä T P; Aaltonen L A
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.
Human molecular genetics 1999;8(1):45-51.
1999: Prior T W; Chadwick R B; Papp A C; Arcot A N; Isa A M; Pearl D K; Stemmermann G; Percesepe A; Loukola A; Aaltonen L A; De La Chapelle A
The I1307K polymorphism of the APC gene in colorectal cancer.
Gastroenterology 1999;116(1):58-63.
1998: Tsao J L; Zhang J; Salovaara R; Li Z H; Järvinen H J; Mecklin J P; Aaltonen L A; Shibata D
Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture.
The American journal of pathology 1998;153(4):1189-200.
1998: Percesepe A; Kristo P; Aaltonen L A; Ponz de Leon M; de la Chapelle A; Peltomäki P
Mismatch repair genes and mononucleotide tracts as mutation targets in colorectal tumors with different degrees of microsatellite instability.
Oncogene 1998;17(2):157-63.
1998: Avizienyte E; Roth S; Loukola A; Hemminki A; Lothe R A; Stenwig A E; Fosså S D; Salovaara R; Aaltonen L A
Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.
Cancer research 1998;58(10):2087-90.
1998: Aaltonen L A; Salovaara R; Kristo P; Canzian F; Hemminki A; Peltomäki P; Chadwick R B; Kääriäinen H; Eskelinen M; Järvinen H; Mecklin J P; de la Chapelle A
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease.
The New England journal of medicine 1998;338(21):1481-7.
1998: Howe J R; Roth S; Ringold J C; Summers R W; Järvinen H J; Sistonen P; Tomlinson I P; Houlston R S; Bevan S; Mitros F A; Stone E M; Aaltonen L A
Mutations in the SMAD4/DPC4 gene in juvenile polyposis.
Science (New York, N.Y.) 1998;280(5366):1086-8.
1998: Roth S; Kristo P; Auranen A; Shayehgi M; Seal S; Collins N; Barfoot R; Rahman N; Klemi P J; Grénman S; Sarantaus L; Nevanlinna H; Butzow R; Ashworth A; Stratton M R; Aaltonen L A
A missense mutation in the BRCA2 gene in three siblings with ovarian cancer.
British journal of cancer 1998;77(8):1199-202.
1998: Hemminki A; Höglund P; Pukkala E; Salovaara R; Järvinen H; Norio R; Aaltonen L A
Intestinal cancer in patients with a germline mutation in the down-regulated in adenoma (DRA) gene.
Oncogene 1998;16(5):681-4.
1998: Hemminki A; Markie D; Tomlinson I; Avizienyte E; Roth S; Loukola A; Bignell G; Warren W; Aminoff M; Höglund P; Järvinen H; Kristo P; Pelin K; Ridanpää M; Salovaara R; Toro T; Bodmer W; Olschwang S; Olsen A S; Stratton M R; de la Chapelle A; Aaltonen L A
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.
Nature 1998;391(6663):184-7.
1998: Hemminki A; Avizienyte E; Roth S; Loukola A; Aaltonen L A; Järvinen H; de la Chapelle A
[A serine/threonine kinase gene defective in Peutz-Jeghers syndrome]
Duodecim; lääketieteellinen aikakauskirja 1998;114(7):667-8.
1998: Aaltonen L A
Molecular epidemiology of hereditary nonpolyposis colorectal cancer in Finland.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;154():306-11.
1997: Marsh D J; Roth S; Lunetta K L; Hemminki A; Dahia P L; Sistonen P; Zheng Z; Caron S; van Orsouw N J; Bodmer W F; Cottrell S E; Dunlop M G; Eccles D; Hodgson S V; Järvinen H; Kellokumpu I; Markie D; Neale K; Phillips R; Rozen P; Syngal S; Vijg J; Tomlinson I P; Aaltonen L A; Eng C
Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome.
Cancer research 1997;57(22):5017-21.
1997: Aarnio M; Salovaara R; Aaltonen L A; Mecklin J P; Järvinen H J
Features of gastric cancer in hereditary non-polyposis colorectal cancer syndrome.
International journal of cancer. Journal international du cancer 1997;74(5):551-5.
1997: Wu Y; Nyström-Lahti M; Osinga J; Looman M W; Peltomäki P; Aaltonen L A; de la Chapelle A; Hofstra R M; Buys C H
MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis.
Genes, chromosomes & cancer 1997;18(4):269-78.
1997: Wolf M; Aaltonen L A; Szymanska J; Tarkkanen M; Elomaa I; Knuutila S
Microsatellite markers as tools for characterization of DNA amplifications evaluated by comparative genomic hybridization.
Cancer genetics and cytogenetics 1997;93(1):33-8.
1997: Wolf M; Aaltonen L A; Szymanska J; Tarkkanen M; Blomqvist C; Berner J M; Myklebost O; Knuutila S
Complexity of 12q13-22 amplicon in liposarcoma: microsatellite repeat analysis.
Genes, chromosomes & cancer 1997;18(1):66-70.
1997: Hemminki A; Tomlinson I; Markie D; Järvinen H; Sistonen P; Björkqvist A M; Knuutila S; Salovaara R; Bodmer W; Shibata D; de la Chapelle A; Aaltonen L A
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis.
Nature genetics 1997;15(1):87-90.
1996: Tarkkanen M; Aaltonen L A; Böhling T; Kivioja A; Karaharju E; Elomaa I; Knuutila S
No evidence of microsatellite instability in bone tumours.
British journal of cancer 1996;74(3):453-5.
1996: Canzian F; Salovaara R; Hemminki A; Kristo P; Chadwick R B; Aaltonen L A; de la Chapelle A
Semiautomated assessment of loss of heterozygosity and replication error in tumors.
Cancer research 1996;56(14):3331-7.
1996: Li Z H; Aaltonen L A; Shu Q; Srivastava S; Grizzle W E; Shibata D
Effects of mutation and growth rates on patterns of microsatellite instability.
The American journal of pathology 1996;148(6):1757-61.
1996: Shibata D; Navidi W; Salovaara R; Li Z H; Aaltonen L A
Somatic microsatellite mutations as molecular tumor clocks.
Nature medicine 1996;2(6):676-81.
1996: Li Z H; Salovaara R; Aaltonen L A; Shibata D
Telomerase activity is commonly detected in hereditary nonpolyposis colorectal cancers.
The American journal of pathology 1996;148(4):1075-9.
1996: Sankila R; Aaltonen L A; Järvinen H J; Mecklin J P
Better survival rates in patients with MLH1-associated hereditary colorectal cancer.
Gastroenterology 1996;110(3):682-7.
1995: Aarnio M; Mecklin J P; Aaltonen L A; Nyström-Lahti M; Järvinen H J
Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome.
International journal of cancer. Journal international du cancer 1995;64(6):430-3.
1995: Nyström-Lahti M; Kristo P; Nicolaides N C; Chang S Y; Aaltonen L A; Moisio A L; Järvinen H J; Mecklin J P; Kinzler K W; Vogelstein B
Founding mutations and Alu-mediated recombination in hereditary colon cancer.
Nature medicine 1995;1(11):1203-6.
1994: Hemminki A; Peltomäki P; Mecklin J P; Järvinen H; Salovaara R; Nyström-Lahti M; de la Chapelle A; Aaltonen L A
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer.
Nature genetics 1994;8(4):405-10.
1994: Nyström-Lahti M; Parsons R; Sistonen P; Pylkkänen L; Aaltonen L A; Leach F S; Hamilton S R; Watson P; Bronson E; Fusaro R
Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage.
American journal of human genetics 1994;55(4):659-65.
1994: Aaltonen L A; Peltomäki P
Genes involved in hereditary nonpolyposis colorectal carcinoma.
Anticancer research 1994;14(4B):1657-60.
1994: Nyström-Lahti M; Sistonen P; Mecklin J P; Pylkkänen L; Aaltonen L A; Järvinen H; Weissenbach J; de la Chapelle A; Peltomäki P
Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):6054-8.
1994: Aaltonen L A; Peltomäki P; Mecklin J P; Järvinen H; Jass J R; Green J S; Lynch H T; Watson P; Tallqvist G; Juhola M
Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.
Cancer research 1994;54(7):1645-8.
1994: Aaltonen L A; Sankila R; Mecklin J P; Järvinen H; Pukkala E; Peltomäki P; de la Chapelle A
A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden.
Cancer detection and prevention 1994;18(1):57-63.
1993: Leach F S; Nicolaides N C; Papadopoulos N; Liu B; Jen J; Parsons R; Peltomäki P; Sistonen P; Aaltonen L A; Nyström-Lahti M
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.
Cell 1993;75(6):1215-25.
1993: Peltomäki P; Lothe R A; Aaltonen L A; Pylkkänen L; Nyström-Lahti M; Seruca R; David L; Holm R; Ryberg D; Haugen A
Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.
Cancer research 1993;53(24):5853-5.
1993: Lothe R A; Peltomäki P; Meling G I; Aaltonen L A; Nyström-Lahti M; Pylkkänen L; Heimdal K; Andersen T I; Møller P; Rognum T O
Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.
Cancer research 1993;53(24):5849-52.
1993: Aaltonen L A; Peltomäki P; Leach F S; Sistonen P; Pylkkänen L; Mecklin J P; Järvinen H; Powell S M; Jen J; Hamilton S R
Clues to the pathogenesis of familial colorectal cancer.
Science (New York, N.Y.) 1993;260(5109):812-6.
1993: Peltomäki P; Aaltonen L A; Sistonen P; Pylkkänen L; Mecklin J P; Järvinen H; Green J S; Jass J R; Weber J L; Leach F S
Genetic mapping of a locus predisposing to human colorectal cancer.
Science (New York, N.Y.) 1993;260(5109):810-2.
1992: Peltomäki P; Sistonen P; Mecklin J P; Pylkkänen L; Aaltonen L; Nordling S; Kere J; Järvinen H; Hamilton S R; Petersen G
Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma.
Cancer research 1992;52(16):4530-3.

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