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Francis Spinale

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Joseph S Janicki; Francis G Spinale; Scott P Levick
Gender differences in non-ischemic myocardial remodeling: are they due to estrogen modulation of cardiac mast cells and/or membrane type 1 matrix metalloproteinase.
Edie C Goldsmith; Amy D Bradshaw; Francis G Spinale
Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression.
Francis G Spinale
Epilysin (matrix metalloproteinase-28) joins the matrix metalloproteinase team on the field of postmyocardial infarction remodeling.

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All Publications

2013: Joseph S Janicki; Francis G Spinale; Scott P Levick
Gender differences in non-ischemic myocardial remodeling: are they due to estrogen modulation of cardiac mast cells and/or membrane type 1 matrix metalloproteinase.
Pflügers Archiv : European journal of physiology 2013;465(5):687-97.
2013: Edie C Goldsmith; Amy D Bradshaw; Francis G Spinale
Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression.
American journal of physiology. Cell physiology 2013;304(5):C393-402.
2013: Francis G Spinale
Epilysin (matrix metalloproteinase-28) joins the matrix metalloproteinase team on the field of postmyocardial infarction remodeling.
Circulation research 2013;112(4):579-82.
2013: Francis G Spinale; Joseph S Janicki; Michael R Zile
Membrane-associated matrix proteolysis and heart failure.
Circulation research 2013;112(1):195-208.
2013: Shaina R Eckhouse; Jeffrey A Jones; Christina B Logdon; Rupak Mukherjee; Elizabeth K Nadeau; J Marshall Oelsen; Elizabeth C O'Quinn; Adam W Akerman; Robert E Stroud; Francis G Spinale
Differential membrane type 1 matrix metalloproteinase substrate processing with ischemia-reperfusion: relationship to interstitial microRNA dynamics and myocardial function.
The Journal of thoracic and cardiovascular surgery 2013;145(1):267-275, 277.e1-4; discussion 275-7.
2013: Shaina R Eckhouse; Jeffrey A Jones; Francis G Spinale
Gene targeting in ischemic heart disease and failure: translational and clinical studies.
Biochemical pharmacology 2013;85(1):1-11.
2012: Sonisha A Warren; Monte S Willis; Huadong Zeng; Laura E Briggs; Eileen I Chang; Joyce Chuang; Stewart H Lecker; Moyi Li; Julie Maupin-Furlowe; Julie R McMullen; Richard L Moss; Francis G Spinale; Maurice S Swanson; Ryota Terada; Hideko Kasahara
Myosin light chain phosphorylation is critical for adaptation to cardiac stress.
Circulation 2012;126(22):2575-88.
2012: Steven R Houser; David A Kass; Walter Koch; Walter J Koch; Kenneth B Margulies; Jeffery D Molkentin; Anne M Murphy; Sumanth D Prabhu; Howard A Rockman; Francis G Spinale; Mark A Sussman; Gary S Francis
Animal models of heart failure: a scientific statement from the American Heart Association.
Circulation research 2012;111(1):131-50.
2012: R A Malinauskas; R M Sade; Francis G Spinale; F A Crawford; J P Dearing; A F von Recum
Blood damaging effects in cardiotomy suction return. 1988.
The Journal of extra-corporeal technology 2012;44(2):84-9.
2012: Essa M Essa; Richard J Gumina; Carl V Leier; Allison Rice; Robert E Stroud; Michael R Zile; Francis G Spinale
Changes in plasma profiles of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in stress-induced cardiomyopathy.
Journal of cardiac failure 2012;18(6):487-92.
2012: Eric M Graham; A Lauren Haney; Francis X McGowan; Scott T Reeves; Andrew M Atz; Scott M Bradley; Rachael L Deardorff; Stacia M. DeSantis; Jenna Gillis; Walter E Uber; Francis G Spinale
Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery.
The Journal of thoracic and cardiovascular surgery 2012;143(5):1069-76.
2012: Michael R Zile; Robert E Stroud; An Van Laer; Jazmine Arroyo; Catalin F Baicu; Jeffrey A Jones; Rupak Mukherjee; Francis G Spinale
Pressure overload-dependent membrane type 1-matrix metalloproteinase induction: relationship to LV remodeling and fibrosis.
American journal of physiology. Heart and circulatory physiology 2012;302(7):H1429-37.
2012: William M Yarbrough; Michael R Zile; John S Ikonomidis; Rupak Mukherjee; Francis G Spinale
Myocardial remodeling with aortic stenosis and after aortic valve replacement: mechanisms and future prognostic implications.
The Journal of thoracic and cardiovascular surgery 2012;143(3):656-64.
2012: John S Ikonomidis; Jazmine Arroyo; Joseph E Bavaria; Stewart M Benton; Theresa A Brinsa; Joseph H Gorman; Robert Gorman; Jean Marie Ruddy; Francis G Spinale; Robert E Stroud; Ahmad Zeeshan; Jeffrey A Jones
Aortic dilatation with bicuspid aortic valves: cusp fusion correlates to matrix metalloproteinases and inhibitors.
The Annals of thoracic surgery 2012;93(2):457-63.
2012: Shaina R Eckhouse; Francis G Spinale
Changes in the myocardial interstitium and contribution to the progression of heart failure.
Heart failure clinics 2012;8(1):7-20.
2011: Eric M Graham; Scott T Reeves; Sinai C Zyblewski; Andrew M Atz; Nathaniel L Baker; Scott M Bradley; Ryan J Butts; Rachael L Deardorff; Stacia M. DeSantis; Francis G Spinale
Standardized preoperative corticosteroid treatment in neonates undergoing cardiac surgery: results from a randomized trial.
The Journal of thoracic and cardiovascular surgery 2011;142(6):1523-9.
2011: Francis G Spinale
Diversity of myocardial interstitial proteolytic pathways: gene deletion reveals unexpected consequences.
Circulation 2011;124(19):2052-5.
2011: Jennifer A Dixon; William F Gaillard; Amy M Goodman; John S Ikonomidis; Richard A McKinney; Rupak Mukherjee; William T Rivers; Nathaniel L Baker; Francis G Spinale
Hemodynamics and myocardial blood flow patterns after placement of a cardiac passive restraint device in a model of dilated cardiomyopathy.
The Journal of thoracic and cardiovascular surgery 2011;142(5):1038-45.
2011: Juozas A Zavadzkas; Robert E Stroud; Laurel E Black; Richard A McKinney; Evan C Meyer; Rupak Mukherjee; J Marshall Oelsen; Risha K Patel; William T Rivers; Francis G Spinale
Direct regulation of membrane type 1 matrix metalloproteinase following myocardial infarction causes changes in survival, cardiac function, and remodeling.
American journal of physiology. Heart and circulatory physiology 2011;301(4):H1656-66.
2011: Stacia M. DeSantis; John S Ikonomidis; John M Kratz; Martha R Stroud; J Matthew Toole; Walter E Uber; Margaret J Wheat; Francis G Spinale
Early postoperative outcomes and blood product utilization in adult cardiac surgery: the post-aprotinin era.
Circulation 2011;124(11 Suppl):S62-9.
2011: Jennifer A Dixon; Joseph H Gorman; Robert C Gorman; Hirotsugu Hamamoto; Evan C Meyer; Masato Morita; Rupak Mukherjee; Liam P Ryan; Nathaniel L Baker; Robert E Stroud; Francis G Spinale
Targeted regional injection of biocomposite microspheres alters post-myocardial infarction remodeling and matrix proteolytic pathways.
Circulation 2011;124(11 Suppl):S35-45.
2011: Francis G Spinale; Jennifer A Dixon
Stem cells and cardiac surgery- the road ahead.
Journal of the South Carolina Medical Association (1975) 2011;107(4):150-2.
2011: Zakir H Sahul; Donald P Dione; Lawrence W Dobrucki; James S Duncan; Jarod McAteer; Rupak Mukherjee; Xenophon Papademetris; James Song; Francis G Spinale; Lawrence Staib; Robert E Stroud; Albert J Sinusas
Targeted imaging of the spatial and temporal variation of matrix metalloproteinase activity in a porcine model of postinfarct remodeling: relationship to myocardial dysfunction.
Circulation. Cardiovascular imaging 2011;4(4):381-91.
2011: Michael R Zile; Stacia M Desantis; Catalin F Baicu; Robert E Stroud; Sheila B Thompson; Catherine D McClure; Shannon M Mehurg; Francis G Spinale
Plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure.
Circulation. Heart failure 2011;4(3):246-56.
2011: Daryl L Reust; William T Rivers; Robert E Stroud; James H Abernathy; Jennifer A Dixon; Kevin Groves; Karen Madden; Richard A McKinney; Rupak Mukherjee; Risha K Patel; Milind Rajopadhye; Scott T Reeves; Francis G Spinale
Continuous localized monitoring of plasmin activity identifies differential and regional effects of the serine protease inhibitor aprotinin: relevance to antifibrinolytic therapy.
Journal of cardiovascular pharmacology 2011;57(4):400-6.
2011: R D Warters; T A Szabo; Francis G Spinale; Stacia M. DeSantis; Joseph Gerald Reves
The effect of neuromuscular blockade on mask ventilation.
Anaesthesia 2011;66(3):163-7.
2011: Alessandro Giardini; Jeremy M Ringewald; Robert E Stroud; Geoffrey A Forbus; Scott M Bradley; Wendy Chung; Francis G Spinale
Determinants of extracellular matrix remodelling are differentially expressed in paediatric and adult dilated cardiomyopathy.
European journal of heart failure 2011;13(3):271-7.
2011: Alessandro Giardini; Jeremy M Ringewald; Robert E Stroud; Nadia Roessler; Nidhi Kumar; Scott T Reeves; Francis G Spinale
Plasma profiling determinants of matrix homeostasis in paediatric dilated cardiomyopathy.
Cardiology in the young 2011;21(1):52-61.
2011: Jennifer A Dixon; Francis G Spinale
Myocardial remodeling: cellular and extracellular events and targets.
Annual review of physiology 2011;73():47-68.
2010: Kenneth A Ellenbogen; Michael R Gold; Timothy E Meyer; Ignacio Fernndez Lozano; Suneet Mittal; Alan D Waggoner; Bernd Lemke; Jagmeet P Singh; Francis G Spinale; Jennifer E Van Eyk; Jeffrey Whitehill; Stanislav Weiner; Maninder Bedi; Joshua Rapkin; Kenneth M Stein
Primary results from the SmartDelay determined AV optimization: a comparison to other AV delay methods used in cardiac resynchronization therapy (SMART-AV) trial: a randomized trial comparing empirical, echocardiography-guided, and algorithmic atrioventricular delay programming in cardiac resynchronization therapy.
Circulation 2010;122(25):2660-8.
2010: Jennifer A Dixon; William F Gaillard; William T Rivers; Christine N Koval; Robert E Stroud; Rupak Mukherjee; Francis G Spinale
Heterogeneity in MT1-MMP activity with ischemia-reperfusion and previous myocardial infarction: relation to regional myocardial function.
American journal of physiology. Heart and circulatory physiology 2010;299(6):H1947-58.
2010: Tim C McQuinn; Rachael L Deardorff; Rupak Mukherjee; Anna Greta B Taylor; Eric M Graham; Andrew M Atz; Geoffrey A Forbus; Stacia M DeSantis; Jennifer B Young; Robert E Stroud; Fred A Crawford; Scott M Bradley; Scott T Reeves; Francis G Spinale
Circulating matrix metalloproteinase levels after ventricular septal defect repair in infants.
The Journal of thoracic and cardiovascular surgery 2010;140(6):1257-65.
2010: Rupak Mukherjee; Tim C McQuinn; Melissa A Dugan; J Philip Saul; Francis G Spinale
Cardiac function and circulating cytokines after endotoxin exposure in neonatal mice.
Pediatric research 2010;68(5):381-6.
2010: Rupak Mukherjee; Gregory P Colbath; Charles D Justus; James A Bruce; Claire M Allen; Kenneth W Hewett; J Philip Saul; Robert G Gourdie; Francis G Spinale
Spatiotemporal induction of matrix metalloproteinase-9 transcription after discrete myocardial injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(10):3819-28.
2010: Francis G Spinale; Rupak Mukherjee; Juozas A Zavadzkas; Christine N Koval; Shenikqua Bouges; Robert E Stroud; Lawrence W Dobrucki; Albert J Sinusas
Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarction.
The Journal of biological chemistry 2010;285(39):30316-27.
2010: Chadrick E Denlinger; John S Ikonomidis; Carolyn E Reed; Francis G Spinale
Epithelial to mesenchymal transition: the doorway to metastasis in human lung cancers.
The Journal of thoracic and cardiovascular surgery 2010;140(3):505-13.
2010: Jeffrey A Jones; Juozas A Zavadzkas; Eileen I Chang; Nina Sheats; Christine Koval; Robert E Stroud; Francis G Spinale; John S Ikonomidis
Cellular phenotype transformation occurs during thoracic aortic aneurysm development.
The Journal of thoracic and cardiovascular surgery 2010;140(3):653-9.
2010: Francis G Spinale
Amplified bioactive signaling and proteolytic enzymes following ischemia reperfusion and aging: remodeling pathways that are not like a fine wine.
Circulation 2010;122(4):322-4.
2010: Rupak Mukherjee; William T Rivers; Jean Marie Ruddy; Robert G Matthews; Christine N Koval; Rebecca A Plyler; Eileen I Chang; Risha K Patel; Christine B Kern; Robert E Stroud; Francis G Spinale
Long-term localized high-frequency electric stimulation within the myocardial infarct: effects on matrix metalloproteinases and regional remodeling.
Circulation 2010;122(1):20-32.
2010: Rupak Mukherjee; Juozas A Zavadzkas; William T Rivers; Julie E McLean; Eileen I Chang; Shenikqua Bouges; Robert G Matthews; Christine N Koval; Robert E Stroud; Francis G Spinale
Short-term disruption in regional left ventricular electrical conduction patterns increases interstitial matrix metalloproteinase activity.
American journal of physiology. Heart and circulatory physiology 2010;299(1):H217-24.
2010: Jeffrey A Jones; Jean Marie Ruddy; Shenikqua Bouges; Juozas A Zavadzkas; Theresa A Brinsa; Robert E Stroud; Rupak Mukherjee; Francis G Spinale; John S Ikonomidis
Alterations in membrane type-1 matrix metalloproteinase abundance after the induction of thoracic aortic aneurysm in a murine model.
American journal of physiology. Heart and circulatory physiology 2010;299(1):H114-24.
2010: Alessandro Giardini; Tim C McQuinn; Rupak Mukherjee; Rachael L Deardorff; Jerry E Squires; Robert E Stroud; Fred A Crawford; Scott M Bradley; Scott T Reeves; Francis G Spinale
Effects of aprotinin or tranexamic acid on proteolytic/cytokine profiles in infants after cardiac surgery.
The Annals of thoracic surgery 2010;89(6):1843-52; discussion 1852.
2010: Guangwu Wang; Tariq Hamid; Rachel J Keith; Guihua Zhou; Charles R Partridge; Xilin Xiang; Justin R Kingery; Robert K Lewis; Qianhong Li; D Gregg Rokosh; Rachael Ford; Francis G Spinale; Daniel W Riggs; Sanjay Srivastava; Aruni Bhatnagar; Roberto Bolli; Sumanth D Prabhu
Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart.
Circulation 2010;121(17):1912-25.
2010: Daryl L Reust; Scott T Reeves; James H Abernathy; Jennifer A Dixon; William F Gaillard; Rupak Mukherjee; Christine N Koval; Robert E Stroud; Francis G Spinale
Interstitial plasmin activity with epsilon aminocaproic acid: temporal and regional heterogeneity.
The Annals of thoracic surgery 2010;89(5):1538-45.
2010: Jennifer A Dixon; Francis G Spinale
Pathophysiology of myocardial injury and remodeling: implications for molecular imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51 Suppl 1():102S-106S.
2010: Sonam A Shah; Francis G Spinale; John S Ikonomidis; Robert E Stroud; Eileen I Chang; Carolyn E Reed
Differential matrix metalloproteinase levels in adenocarcinoma and squamous cell carcinoma of the lung.
The Journal of thoracic and cardiovascular surgery 2010;139(4):984-90; discussion 990.
2010: Daryl L Reust; Scott T Reeves; James H Abernathy; Jennifer A Dixon; William F Gaillard; Rupak Mukherjee; Christine N Koval; Robert E Stroud; Francis G Spinale
Temporally and regionally disparate differences in plasmin activity by tranexamic acid.
Anesthesia and analgesia 2010;110(3):694-701.
2010: John M Toole; John S Ikonomidis; Wilson Y Szeto; James L Zellner; John Mulcahy; Rachael L Deardorff; Francis G Spinale
Selective endothelin-1 receptor type A inhibition in subjects undergoing cardiac surgery with preexisting left ventricular dysfunction: Influence on early postoperative hemodynamics.
The Journal of thoracic and cardiovascular surgery 2010;139(3):646-54.
2010: Kenneth M Stein; Kenneth A Ellenbogen; Michael R Gold; Bernd Lemke; Ignacio Fernández Lozano; Suneet Mittal; Francis G Spinale; Jennifer E Van Eyk; Alan D Waggoner; Timothy E Meyer
SmartDelay determined AV optimization: a comparison of AV delay methods used in cardiac resynchronization therapy (SMART-AV): rationale and design.
Pacing and clinical electrophysiology : PACE 2010;33(1):54-63.
2009: Santhosh K Mani; Sundaravadivel Balasubramanian; Juozas A Zavadzkas; Laura B Jeffords; William T Rivers; Michael R Zile; Rupak Mukherjee; Francis G Spinale; Dhandapani Kuppuswamy
Calpain inhibition preserves myocardial structure and function following myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2009;297(5):H1744-51.
2009: Jeffrey Jones; Christy Beck; John R Barbour; Jouzas A Zavadzkas; Rupak Mukherjee; Francis G Spinale; John S Ikonomidis
Alterations in aortic cellular constituents during thoracic aortic aneurysm development: myofibroblast-mediated vascular remodeling.
The American journal of pathology 2009;175(4):1746-56.
2009: Jean Marie Ruddy; Jeffrey Jones; Robert E Stroud; Rupak Mukherjee; Francis G Spinale; John S Ikonomidis
Differential effects of mechanical and biological stimuli on matrix metalloproteinase promoter activation in the thoracic aorta.
Circulation 2009;120(11 Suppl):S262-8.
2009: Jennifer A Dixon; Robert C Gorman; Robert E Stroud; Shenikqua Bouges; Hamamoto Hirotsugu; Joseph H Gorman; Timothy P Martens; Silviu Itescu; Michael D Schuster; Theodore Plappert; Martin G St John-Sutton; Francis G Spinale
Mesenchymal cell transplantation and myocardial remodeling after myocardial infarction.
Circulation 2009;120(11 Suppl):S220-9.
2009: Francis G Spinale; Nikole M Wilbur
Matrix metalloproteinase therapy in heart failure.
Current treatment options in cardiovascular medicine 2009;11(4):339-46.
2009: Francis G Spinale; G Patricia Escobar; Rupak Mukherjee; Juozas A Zavadzkas; Stuart M Saunders; Laura B Jeffords; Allyson M Leone; Christy Beck; Shenikqua Bouges; Robert E Stroud
Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging.
Circulation. Heart failure 2009;2(4):351-60.
2009: Jennifer A Dixon; Francis G Spinale
Large animal models of heart failure: a critical link in the translation of basic science to clinical practice.
Circulation. Heart failure 2009;2(3):262-71.
2009: Matt Mcevoy; Michel J Sabbagh; Anna Greta Taylor; Juozas A Zavadzkas; Christine N Koval; Robert E Stroud; Rachael L Ford; Julie E McLean; Scott T Reeves; Rupak Mukherjee; Francis G Spinale
Aprotinin modifies left ventricular contractility and cytokine release after ischemia-reperfusion in a dose-dependent manner in a murine model.
Anesthesia and analgesia 2009;108(2):399-406.
2009: Jeffrey Jones; Francis G Spinale; John S Ikonomidis
Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis.
Journal of vascular research 2009;46(2):119-37.
2008: Rachael L Ford; Ira M Mains; Ebony J Hilton; Scott T Reeves; Robert E Stroud; Fred A Crawford; John S Ikonomidis; Francis G Spinale
Endothelin-A receptor inhibition after cardiopulmonary bypass: cytokines and receptor activation.
The Annals of thoracic surgery 2008;86(5):1576-83.
2008: Jean Marie Ruddy; Jeffrey Jones; Francis G Spinale; John S Ikonomidis
Regional heterogeneity within the aorta: relevance to aneurysm disease.
The Journal of thoracic and cardiovascular surgery 2008;136(5):1123-30.
2008: Michel J Sabbagh; J Michael Looper; Juozas A Zavadzkas; Robert E Stroud; Rachael L Ford; William T Rivers; Christine N Koval; Matt Mcevoy; Scott T Reeves; Francis G Spinale
Aprotinin exacerbates left ventricular dysfunction after ischemia/reperfusion in mice lacking tumor necrosis factor receptor I.
Journal of cardiovascular pharmacology 2008;52(4):355-62.
2008: Rupak Mukherjee; Juozas A Zavadzkas; Stuart M Saunders; Julie E McLean; Laura B Jeffords; Christy Beck; Robert E Stroud; Allyson M Leone; Christine N Koval; William T Rivers; Shubhayu Basu; Alexander Sheehy; Gene Michal; Francis G Spinale
Targeted myocardial microinjections of a biocomposite material reduces infarct expansion in pigs.
The Annals of thoracic surgery 2008;86(4):1268-76.
2008: Juozas A Zavadzkas; Rebecca A Plyler; Shenikqua Bouges; Christine N Koval; William T Rivers; Christy U Beck; Eileen I Chang; Robert E Stroud; Rupak Mukherjee; Francis G Spinale
Cardiac-restricted overexpression of extracellular matrix metalloproteinase inducer causes myocardial remodeling and dysfunction in aging mice.
American journal of physiology. Heart and circulatory physiology 2008;295(4):H1394-402.
2008: Francis G Spinale; Christine N Koval; Anne M Deschamps; Robert E Stroud; John S Ikonomidis
Dynamic changes in matrix metalloprotienase activity within the human myocardial interstitium during myocardial arrest and reperfusion.
Circulation 2008;118(14 Suppl):S16-23.
2008: Matt Mcevoy; Anna-Greta Taylor; Juozas A Zavadzkas; Ira M Mains; Rachael L Ford; Robert E Stroud; Laura B Jeffords; Christy U Beck; Scott T Reeves; Francis G Spinale
Aprotinin exerts differential and dose-dependent effects on myocardial contractility, oxidative stress, and cytokine release after ischemia-reperfusion.
The Annals of thoracic surgery 2008;86(2):568-75.
2008: Georges E Haddad; Lori J Saunders; Seth Crosby; Maria Carles; Federica del Monte; Kindra King; Michael R Bristow; Francis G Spinale; Thomas E Macgillivray; Marc J Semigran; G William Dec; Steven A Williams; Roger J Hajjar; Judith K Gwathmey
Human cardiac-specific cDNA array for idiopathic dilated cardiomyopathy: sex-related differences.
Physiological genomics 2008;33(2):267-77.
2008: B Hugh Dorman; Robert E Stroud; Michael M Wyckoff; James L Zellner; Don Botta; Amy H Leonardi; John S Ikonomidis; Francis G Spinale
Differential effects of epsilon-aminocaproic acid and aprotinin on matrix metalloproteinase release in patients following cardiopulmonary bypass.
Journal of cardiovascular pharmacology 2008;51(4):418-23.
2008: Andrew T Yan; Raymond T Yan; Francis G Spinale; Rizwan Afzal; Himali R Gunasinghe; Robert E Stroud; Robert S McKelvie; Peter P Liu
Relationships between plasma levels of matrix metalloproteinases and neurohormonal profile in patients with heart failure.
European journal of heart failure 2008;10(2):125-8.
2008: Anne M Deschamps; Juozas Zavadzkas; Rebecca L Murphy; Christine N Koval; Julie E McLean; Laura Jeffords; Stuart M Saunders; Nina J Sheats; Robert E Stroud; Francis G Spinale
Interruption of endothelin signaling modifies membrane type 1 matrix metalloproteinase activity during ischemia and reperfusion.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H875-83.
2008: Ronen Beeri; Chaim Yosefy; J Luis Guerrero; Francesca Nesta; Suzan Abedat; Miguel Chaput; Federica del Monte; Mark D Handschumacher; Robert Stroud; Suzanne Sullivan; Thea Pugatsch; Dan GILON; Gus J Vlahakes; Francis G Spinale; Roger J Hajjar; Robert A Levine
Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation.
Journal of the American College of Cardiology 2008;51(4):476-86.
2008: Jeffrey Jones; John R Barbour; Robert E Stroud; Shenikqua Bouges; Shelly L Stephens; Francis G Spinale; John S Ikonomidis
Altered transforming growth factor-beta signaling in a murine model of thoracic aortic aneurysm.
Journal of vascular research 2008;45(6):457-68.
2007: Francis G Spinale
Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function.
Physiological reviews 2007;87(4):1285-342.
2007: Matt Mcevoy; Scott T Reeves; Joseph Gerald Reves; Francis G Spinale
Aprotinin in cardiac surgery: a review of conventional and novel mechanisms of action.
Anesthesia and analgesia 2007;105(4):949-62.
2007: Laura S Spruill; Abigail S Lowry; Robert E Stroud; Christina E Squires; I Matthew Mains; English C Flack; Christy Beck; John S Ikonomidis; Arthur J Crumbley; Paul J McDermott; Francis G Spinale
Membrane-type-1 matrix metalloproteinase transcription and translation in myocardial fibroblasts from patients with normal left ventricular function and from patients with cardiomyopathy.
American journal of physiology. Cell physiology 2007;293(4):C1362-73.
2007: Ronen Beeri; Chaim Yosefy; J Luis Guerrero; Suzan Abedat; Mark D Handschumacher; Robert E Stroud; Suzanne Sullivan; Miguel Chaput; Dan GILON; Gus J Vlahakes; Francis G Spinale; Roger J Hajjar; Robert A Levine
Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study.
Circulation 2007;116(11 Suppl):I288-93.
2007: D Dirk Bonnema; Carson S Webb; Weems R Pennington; Robert E Stroud; Amy E Leonardi; Leslie L Clark; Catherine D McClure; Laura Finklea; Francis G Spinale; Michael R Zile
Effects of age on plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs).
Journal of cardiac failure 2007;13(7):530-40.
2007: John S Ikonomidis; Ebony J Hilton; Kim J. Payne; April Harrell; Laura Finklea; Leslie Clark; Scott T Reeves; Robert E Stroud; Amy H Leonardi; Fred A Crawford; Francis G Spinale
Selective endothelin-A receptor inhibition after cardiac surgery: a safety and feasibility study.
The Annals of thoracic surgery 2007;83(6):2153-60; discussion 2161.
2007: John R Barbour; Francis G Spinale; John S Ikonomidis
Proteinase systems and thoracic aortic aneurysm progression.
The Journal of surgical research 2007;139(2):292-307.
2007: John S Ikonomidis; Jeffrey Jones; John R Barbour; Robert E Stroud; Leslie L Clark; Brooke S Kaplan; Ahmad Zeeshan; Joseph E Bavaria; Joseph H Gorman; Francis G Spinale; Robert Gorman
Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves.
The Journal of thoracic and cardiovascular surgery 2007;133(4):1028-36.
2006: Rupak Mukherjee; Joseph T Mingoia; James A Bruce; Jeffrey S Austin; Robert E Stroud; G Patricia Escobar; David M McClister; Claire M Allen; Maria A Alfonso-Jaume; M Elizabeth Fini; David H Lovett; Francis G Spinale
Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2006;291(5):H2216-28.
2006: John R Barbour; Robert E Stroud; Abigail S Lowry; Leslie L Clark; Allyson M Leone; Jeffrey Jones; Francis G Spinale; John S Ikonomidis
Temporal disparity in the induction of matrix metalloproteinases and tissue inhibitors of metalloproteinases after thoracic aortic aneurysm formation.
The Journal of thoracic and cardiovascular surgery 2006;132(4):788-95.
2006: Carson S Webb; D Dirk Bonnema; S Hinan Ahmed; Amy H Leonardi; Catherine D McClure; Leslie L Clark; Robert E Stroud; William C Corn; Laura Finklea; Michael R Zile; Francis G Spinale
Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling.
Circulation 2006;114(10):1020-7.
2006: Andrew T Yan; Raymond T Yan; Francis G Spinale; Rizwan Afzal; Himali Gunasinghe; Malcolm Arnold; Catherine Demers; Robert S McKelvie; Peter P Liu
Plasma matrix metalloproteinase-9 level is correlated with left ventricular volumes and ejection fraction in patients with heart failure.
Journal of cardiac failure 2006;12(7):514-9.
2006: Francis G Spinale; G Patricia Escobar; Jennifer W Hendrick; Leslie L Clark; Sarah S Camens; Joseph P Mingoia; Christina G Squires; Robert E Stroud; John S Ikonomidis
Chronic matrix metalloproteinase inhibition following myocardial infarction in mice: differential effects on short and long-term survival.
The Journal of pharmacology and experimental therapeutics 2006;318(3):966-73.
2006: Kimberly A Apple; Julie E McLean; Christina E Squires; Brooke Schaeffer; Jeffrey A Sample; Rebecca L Murphy; Anne M Deschamps; Amy H Leonardi; Claire M Allen; Jennifer W Hendrick; Robert E Stroud; Rupak Mukherjee; Francis G Spinale
Differential effects of protein kinase C isoform activation in endothelin-mediated myocyte contractile dysfunction with cardioplegic arrest and reperfusion.
The Annals of thoracic surgery 2006;82(2):664-71.
2006: John S Ikonomidis; Jeffrey Jones; John R Barbour; Robert E Stroud; Leslie L Clark; Brooke S Kaplan; Ahmad Zeeshan; Joseph E Bavaria; Joseph H Gorman; Francis G Spinale; Robert Gorman
Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome.
Circulation 2006;114(1 Suppl):I365-70.
2006: Rupak Mukherjee; Kimberly A Apple; Christina E Squires; Brooke S Kaplan; Julie E McLean; Stuart M Saunders; Robert E Stroud; Francis G Spinale
Protein kinase C isoform activation and endothelin-1 mediated defects in myocyte contractility after cardioplegic arrest and reperfusion.
Circulation 2006;114(1 Suppl):I308-13.
2006: Merry Lindsey; G Patricia Escobar; Rupak Mukherjee; Danielle K Goshorn; Nina J Sheats; James A Bruce; I Matthew Mains; Jennifer K Hendrick; Kenneth W Hewett; Robert G Gourdie; Lynn M Matrisian; Francis G Spinale
Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction.
Circulation 2006;113(25):2919-28.
2006: S Hinan Ahmed; Leslie L Clark; Weems R Pennington; Carson S Webb; D Dirk Bonnema; Amy H Leonardi; Catherine D McClure; Francis G Spinale; Michael R Zile
Matrix metalloproteinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart disease.
Circulation 2006;113(17):2089-96.
2006: English C Flack; Merry Lindsey; Christina E Squires; Brooke S Kaplan; Robert E Stroud; Leslie L Clark; Patricia G Escobar; William M Yarbrough; Francis G Spinale
Alterations in cultured myocardial fibroblast function following the development of left ventricular failure.
Journal of molecular and cellular cardiology 2006;40(4):474-83.
2006: Leslie L Clark; John S Ikonomidis; Fred A Crawford; Arthur J Crumbley; John M Kratz; Martha R Stroud; Robert F Woolson; James J Bruce; Joyce S Nicholas; Daniel T Lackland; Michael R Zile; Francis G Spinale
Preoperative statin treatment is associated with reduced postoperative mortality and morbidity in patients undergoing cardiac surgery: an 8-year retrospective cohort study.
The Journal of thoracic and cardiovascular surgery 2006;131(3):679-85.
2006: Rupak Mukherjee; Amanda R Herron; Abigail S Lowry; Robert E Stroud; Martha R Stroud; John Marcus Wharton; John S Ikonomidis; Arthur J Crumbley; Francis G Spinale; Michael R Gold
Selective induction of matrix metalloproteinases and tissue inhibitor of metalloproteinases in atrial and ventricular myocardium in patients with atrial fibrillation.
The American journal of cardiology 2006;97(4):532-7.
2006: Andrew C Newby; Matthias Pauschinger; Francis G Spinale
From tadpole tails to transgenic mice: metalloproteinases have brought about a metamorphosis in our understanding of cardiovascular disease.
Cardiovascular research 2006;69(3):559-61.
2006: Anne M Deschamps; Francis G Spinale
Pathways of matrix metalloproteinase induction in heart failure: bioactive molecules and transcriptional regulation.
Cardiovascular research 2006;69(3):666-76.
2006: Kimberly A Apple; William M Yarbrough; Rupak Mukherjee; Anne M Deschamps; Patricia G Escobar; Joseph T Mingoia; Jeffrey A Sample; Jennifer W Hendrick; Kathryn B Dowdy; Julie E McLean; Robert E Stroud; Timothy P O'Neill; Francis G Spinale
Selective targeting of matrix metalloproteinase inhibition in post-infarction myocardial remodeling.
Journal of cardiovascular pharmacology 2006;47(2):228-35.
2006: Merry Lindsey; G Patricia Escobar; Lawrence W Dobrucki; Danielle K Goshorn; Shenikqua Bouges; Joseph T Mingoia; David M McClister; Haili Su; Joseph Gannon; Catherine MacGillivray; Richard T Lee; Albert J Sinusas; Francis G Spinale
Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2006;290(1):H232-9.
2005: Haili Su; Francis G Spinale; Lawrence W Dobrucki; James Song; Jing Hua; Sarah E Sweterlitsch; Donald P Dione; Patti Cavaliere; Conroy Chow; Brian N Bourke; Xiao-Yu Hu; Michael Azure; Padmaja Yalamanchili; Richard Liu; Edward H Cheesman; Simon Robinson; D Scott Edwards; Albert J Sinusas
Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling.
Circulation 2005;112(20):3157-67.
2005: John S Ikonomidis; John R Barbour; Zainab Amani; Robert E Stroud; Amanda R Herron; David M McClister; Sarah E Camens; Merry Lindsey; Rupak Mukherjee; Francis G Spinale
Effects of deletion of the matrix metalloproteinase 9 gene on development of murine thoracic aortic aneurysms.
Circulation 2005;112(9 Suppl):I242-8.
2005: Aaron S Blom; Rupak Mukherjee; James J Pilla; Abigail S Lowry; William M Yarbrough; Joseph T Mingoia; Jennifer W Hendrick; Robert E Stroud; Julie E McLean; John Affuso; Robert Gorman; Joseph H Gorman; Michael A Acker; Francis G Spinale
Cardiac support device modifies left ventricular geometry and myocardial structure after myocardial infarction.
Circulation 2005;112(9):1274-83.
2005: Aaron S Blom; James J Pilla; Robert Gorman; Joseph H Gorman; Rupak Mukherjee; Francis G Spinale; Michael A Acker
Infarct size reduction and attenuation of global left ventricular remodeling with the CorCap cardiac support device following acute myocardial infarction in sheep.
Heart failure reviews 2005;10(2):125-39.
2005: Anne M Deschamps; Kimberly A Apple; Amy H Leonardi; Julie E McLean; William M Yarbrough; Robert E Stroud; Leslie L Clark; Jeffrey A Sample; Francis G Spinale
Myocardial interstitial matrix metalloproteinase activity is altered by mechanical changes in LV load: interaction with the angiotensin type 1 receptor.
Circulation research 2005;96(10):1110-8.
2005: Anne M Deschamps; Francis G Spinale
Matrix modulation and heart failure: new concepts question old beliefs.
Current opinion in cardiology 2005;20(3):211-6.
2005: Merry Lindsey; Danielle K Goshorn; Christina E Squires; G Patricia Escobar; Jennifer W Hendrick; Joseph T Mingoia; Sarah E Sweterlitsch; Francis G Spinale
Age-dependent changes in myocardial matrix metalloproteinase/tissue inhibitor of metalloproteinase profiles and fibroblast function.
Cardiovascular research 2005;66(2):410-9.
2005: Anne M Deschamps; William M Yarbrough; Christina E Squires; Rebecca A Allen; David M McClister; Kathryn B Dowdy; Julie E McLean; Joseph T Mingoia; Jeffrey A Sample; Rupak Mukherjee; Francis G Spinale
Trafficking of the membrane type-1 matrix metalloproteinase in ischemia and reperfusion: relation to interstitial membrane type-1 matrix metalloproteinase activity.
Circulation 2005;111(9):1166-74.
2005: Anne M Deschamps; Francis G Spinale
Disruptions and detours in the myocardial matrix highway and heart failure.
Current heart failure reports 2005;2(1):10-7.
2005: M Marlina Multani; John S Ikonomidis; Peter Y Kim; Elizabeth A Miller; Kim J. Payne; Rupak Mukherjee; B Hugh Dorman; Francis G Spinale
Dynamic and differential changes in myocardial and plasma endothelin in patients undergoing cardiopulmonary bypass.
The Journal of thoracic and cardiovascular surgery 2005;129(3):584-90.
2005: Robert E Stroud; Anne M Deschamps; Abigail S Lowry; Amy E Hardin; Rupak Mukherjee; Merry Lindsey; Sammanda Ramamoorthy; Michael R Zile; William H Spencer; Francis G Spinale
Plasma monitoring of the myocardial specific tissue inhibitor of metalloproteinase-4 after alcohol septal ablation in hypertrophic obstructive cardiomyopathy.
Journal of cardiac failure 2005;11(2):124-30.
2005: John S Ikonomidis; Jennifer W Hendrick; Andrea M Parkhurst; Amanda R Herron; Patricia G Escobar; Kathryn B Dowdy; Robert E Stroud; Elizabeth Hapke; Michael R Zile; Francis G Spinale
Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition.
American journal of physiology. Heart and circulatory physiology 2005;288(1):H149-58.
2004: William M Yarbrough; Rupak Mukherjee; Christina E Squires; Emily S Reese; Jennifer S Leiser; Robert E Stroud; Jeffrey A Sample; Jennifer W Hendrick; Joseph T Mingoia; Julie E McLean; Amy E Hardin; Kathryn B Dowdy; Francis G Spinale
Caspase inhibition attenuates contractile dysfunction following cardioplegic arrest and rewarming in the setting of left ventricular failure.
Journal of cardiovascular pharmacology 2004;44(6):645-50.
2004: Gerald D Buckberg; Myron L Weisfeldt; Manel Ballester; RAFAEL BEYAR; Daniel Burkhoff; H Cecil Coghlan; Mark Doyle; Neal D Epstein; Morteza Gharib; Ray E Ideker; Neil B Ingels; Martin M LeWinter; Andrew D McCulloch; Gerald M Pohost; Leslie J Reinlib; David J Sahn; George Sopko; Francis G Spinale; Henry M Spotnitz; Francisco Torrent-Guasp; Edward P Shapiro
Left ventricular form and function: scientific priorities and strategic planning for development of new views of disease.
Circulation 2004;110(14):e333-6.
2004: Eric M Wilson; Abhinav Diwan; Francis G Spinale; Douglas L Mann
Duality of innate stress responses in cardiac injury, repair, and remodeling.
Journal of molecular and cellular cardiology 2004;37(4):801-11.
2004: John S Ikonomidis; William C Gibson; Jessica E Butler; David M McClister; Sarah E Sweterlitsch; Robert P Thompson; Rupak Mukherjee; Francis G Spinale
Effects of deletion of the tissue inhibitor of matrix metalloproteinases-1 gene on the progression of murine thoracic aortic aneurysms.
Circulation 2004;110(11 Suppl 1):II268-73.
2004: Francis G Spinale
Cell-matrix signaling and thrombospondin: another link to myocardial matrix remodeling.
Circulation research 2004;95(5):446-8.
2004: Jessica R Garner; Robert E Stroud; Laura Finklea; John S Ikonomidis; B Hugh Dorman; Francis G Spinale
The effects of leukocyte reduction on matrix metalloproteinase release in cardiopulmonary bypass.
The Journal of extra-corporeal technology 2004;36(2):185-90.
2004: Rupak Mukherjee; William M Yarbrough; Emily S Reese; Jennifer S Leiser; Jeffrey A Sample; Joseph T Mingoia; Amy E Hardin; Robert E Stroud; Julie E McLean; Jennifer W Hendrick; Francis G Spinale
Myocyte contractility with caspase inhibition and simulated hyperkalemic cardioplegic arrest.
The Annals of thoracic surgery 2004;77(5):1684-9; discussion 1689-90.
2004: Francis G Spinale
Matrix metalloproteinase gene polymorphisms in heart failure: new pieces to the myocardial matrix puzzle.
European heart journal 2004;25(8):631-3.
2004: Rupak Mukherjee; Andrea M Parkhurst; Joseph T Mingoia; Sarah E Sweterlitsch; Jennifer S Leiser; G Patricia Escobar; Francis G Spinale; J Philip Saul
Myocardial remodeling after discrete radiofrequency injury: effects of tissue inhibitor of matrix metalloproteinase-1 gene deletion.
American journal of physiology. Heart and circulatory physiology 2004;286(4):H1242-7.
2004: B Hugh Dorman; John M Kratz; M Marlina Multani; Ruth Baron; Emily Farrar; Scott Walton; Kim J. Payne; John Ikonomiois; Scott T Reeves; Rupak Mukherjee; Francis G Spinale
A prospective, randomized study of endothelin and postoperative recovery in off-pump versus conventional coronary artery bypass surgery.
Journal of cardiothoracic and vascular anesthesia 2004;18(1):25-9.
2004: Abhinav Diwan; Ziad I Dibbs; Shintaro Nemoto; Gilberto Defreitas; Blase A Carabello; Natarajan Sivasubramanian; Eric M Wilson; Francis G Spinale; Douglas L Mann
Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes.
Circulation 2004;109(2):262-8.
2004: R English Chapman; Francis G Spinale
Extracellular protease activation and unraveling of the myocardial interstitium: critical steps toward clinical applications.
American journal of physiology. Heart and circulatory physiology 2004;286(1):H1-H10.
2003: William M Yarbrough; Rupak Mukherjee; G Patricia Escobar; Jeffrey A Sample; Julie E McLean; Kathryn B Dowdy; Jennifer W Hendrick; William C Gibson; Amy E Hardin; Joseph T Mingoia; Patrick C White; Ann Stiko; Robert C Armstrong; Fred A Crawford; Francis G Spinale
Pharmacologic inhibition of intracellular caspases after myocardial infarction attenuates left ventricular remodeling: a potentially novel pathway.
The Journal of thoracic and cardiovascular surgery 2003;126(6):1892-9.
2003: William M Yarbrough; Rupak Mukherjee; G Patricia Escobar; Jennifer W Hendrick; Jeffrey A Sample; Kathryn B Dowdy; Julie E McLean; Joseph T Mingoia; Fred A Crawford; Francis G Spinale
Modulation of calcium transport improves myocardial contractility and enzyme profiles after prolonged ischemia-reperfusion.
The Annals of thoracic surgery 2003;76(6):2054-61; discussion 2061.
2003: William M Yarbrough; Rupak Mukherjee; G Patricia Escobar; Joseph T Mingoia; Jeffrey A Sample; Jennifer W Hendrick; Kathryn B Dowdy; Julie E McLean; Robert E Stroud; Francis G Spinale
Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability.
The Journal of thoracic and cardiovascular surgery 2003;126(5):1489-97.
2003: John S Ikonomidis; William C Gibson; Jonathan Gardner; Sarah E Sweterlitsch; Robert P Thompson; Rupak Mukherjee; Francis G Spinale
A murine model of thoracic aortic aneurysms.
The Journal of surgical research 2003;115(1):157-63.
2003: William M Yarbrough; Rupak Mukherjee; G Patricia Escobar; Joseph T Mingoia; Jeffrey A Sample; Jennifer W Hendrick; Kathryn B Dowdy; Julie E McLean; Abigail S Lowry; Timothy P O'Neill; Francis G Spinale
Selective targeting and timing of matrix metalloproteinase inhibition in post-myocardial infarction remodeling.
Circulation 2003;108(14):1753-9.
2003: Ziad I Dibbs; Abhinav Diwan; Shintaro Nemoto; Gilberto Defreitas; Maha Abdellatif; Blase A Carabello; Francis G Spinale; Giora Feuerstein; Natarajan Sivasubramanian; Douglas L Mann
Targeted overexpression of transmembrane tumor necrosis factor provokes a concentric cardiac hypertrophic phenotype.
Circulation 2003;108(8):1002-8.
2003: Markus Flesch; Anje Höper; Louis J Dell'Italia; Kenda Evans; Richard Bond; ronald peshock; Abhinav Diwan; Theresa A Brinsa; Chih-Chang Wei; Natarajan Sivasubramanian; Francis G Spinale; Douglas L Mann
Activation and functional significance of the renin-angiotensin system in mice with cardiac restricted overexpression of tumor necrosis factor.
Circulation 2003;108(5):598-604.
2003: Eric M Wilson; Sina L Moainie; Julia M Baskin; Abigail S Lowry; Anne M Deschamps; Rupak Mukherjee; Thomas Guy; Martin St John Sutton; Joseph H Gorman; L Henry Edmunds; Robert Gorman; Francis G Spinale
Region- and type-specific induction of matrix metalloproteinases in post-myocardial infarction remodeling.
Circulation 2003;107(22):2857-63.
2003: Susan Schneider; Himali Gunasinghe; Joseph J Sistino; Mindy Blackwell; Francis G Spinale
Effects of leukocyte depletion filters on matrix metalloproteinase activation in an extracorporeal circulation circuit.
The Journal of extra-corporeal technology 2003;35(2):139-42.
2003: R English Chapman; Amelia A Scott; Anne M Deschamps; Abigail S Lowry; Robert E Stroud; John S Ikonomidis; Francis G Spinale
Matrix metalloproteinase abundance in human myocardial fibroblasts: effects of sustained pharmacologic matrix metalloproteinase inhibition.
Journal of molecular and cellular cardiology 2003;35(5):539-48.
2003: William M Yarbrough; Rupak Mukherjee; Theresa A Brinsa; Kathryn B Dowdy; Amelia A Scott; G Patricia Escobar; Cassandra Joffs; David G Lucas; Fred A Crawford; Francis G Spinale
Matrix metalloproteinase inhibition modifies left ventricular remodeling after myocardial infarction in pigs.
The Journal of thoracic and cardiovascular surgery 2003;125(3):602-10.
2003: Mary K King; Mytsi L Coker; Aaron Goldberg; James H McElmurray; Himali Gunasinghe; Rupak Mukherjee; Michael R Zile; Timothy P O'Neill; Francis G Spinale
Selective matrix metalloproteinase inhibition with developing heart failure: effects on left ventricular function and structure.
Circulation research 2003;92(2):177-85.
2003: Rupak Mukherjee; Theresa A Brinsa; Kathryn B Dowdy; Amelia A Scott; Julia M Baskin; Anne M Deschamps; Abigail S Lowry; G Patricia Escobar; David G Lucas; William M Yarbrough; Michael R Zile; Francis G Spinale
Myocardial infarct expansion and matrix metalloproteinase inhibition.
Circulation 2003;107(4):618-25.
2003: Merry Lindsey; Douglas L Mann; Mark L Entman; Francis G Spinale
Extracellular matrix remodeling following myocardial injury.
Annals of medicine 2003;35(5):316-26.
2003: William M Yarbrough; Francis G Spinale
Large animal models of congestive heart failure: a critical step in translating basic observations into clinical applications.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2003;10(1):77-86.
2003: Catalin F Baicu; Jason D Stroud; Virginia A Livesay; Elizabeth Hapke; Jennifer Holder; Francis G Spinale; Michael R Zile
Changes in extracellular collagen matrix alter myocardial systolic performance.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H122-32.
2003: Esther Creemers; Jeniffer N Davis; Andrea M Parkhurst; Peter Leenders; Kathryn B Dowdy; Elizabeth Hapke; Anne M Hauet; Patricia G Escobar; Jack P M Cleutjens; Jos F M Smits; Mat J A P Daemen; Michael R Zile; Francis G Spinale
Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H364-71.
2002: William S Bradham; Himali Gunasinghe; Jennifer R Holder; Marlina Multani; Donna Killip; Marianne Anderson; Denise Meyer; William H Spencer; Guillermo Torre Amione; Francis G Spinale
Release of matrix metalloproteinases following alcohol septal ablation in hypertrophic obstructive cardiomyopathy.
Journal of the American College of Cardiology 2002;40(12):2165-73.
2002: Francis G Spinale
Bioactive peptide signaling within the myocardial interstitium and the matrix metalloproteinases.
Circulation research 2002;91(12):1082-4.
2002: Francis G Spinale
The extracellular matrix: summation.
Journal of cardiac failure 2002;8(6 Suppl):S349-50.
2002: Francis G Spinale; Himali Gunasinghe; Philip D Sprunger; Julia M Baskin; William C Bradham
Extracellular degradative pathways in myocardial remodeling and progression to heart failure.
Journal of cardiac failure 2002;8(6 Suppl):S332-8.
2002: Eric M Wilson; Himali Gunasinghe; Mytsi L Coker; Philip Sprunger; Dorellyn Lee-Jackson; Biykem Bozkurt; Anita Deswal; Douglas L Mann; Francis G Spinale
Plasma matrix metalloproteinase and inhibitor profiles in patients with heart failure.
Journal of cardiac failure 2002;8(6):390-8.
2002: Rupak Mukherjee; M Marlina Multani; Jeffrey A Sample; Kathryn B Dowdy; James L Zellner; Donald B Hoover; Francis G Spinale
Effects of adrenomedullin on human myocyte contractile function and beta-adrenergic response.
Journal of cardiovascular pharmacology and therapeutics 2002;7(4):235-40.
2002: Francis G Spinale
The bioactive peptide endothelin causes multiple biologic responses relevant to myocardial and vascular performance after cardiac surgery.
The Journal of thoracic and cardiovascular surgery 2002;123(6):1031-4.
2002: Jason D Stroud; Catalin F Baicu; Mary A Barnes; Francis G Spinale; Michael R Zile
Viscoelastic properties of pressure overload hypertrophied myocardium: effect of serine protease treatment.
American journal of physiology. Heart and circulatory physiology 2002;282(6):H2324-35.
2002: David G Lucas; Jennifer W Hendrick; Jeffrey A Sample; Rupak Mukherjee; G Patricia Escobar; Glenn Smits; Fred A Crawford; Francis G Spinale
Cardiorenal effects of adenosine subtype 1 (A1) receptor inhibition in an experimental model of heart failure.
Journal of the American College of Surgeons 2002;194(5):603-9.
2002: Gilbert J Perry; Chih-Chang Wei; Gerald H Hankes; S Ray Dillon; Patricia Rynders; Rupak Mukherjee; Francis G Spinale; Louis J Dell'Italia
Angiotensin II receptor blockade does not improve left ventricular function and remodeling in subacute mitral regurgitation in the dog.
Journal of the American College of Cardiology 2002;39(8):1374-9.
2002: William S Bradham; Gordon W Moe; Katherine A Wendt; Amelia A Scott; Andrea Konig; Marina Romanova; George Naik; Francis G Spinale
TNF-alpha and myocardial matrix metalloproteinases in heart failure: relationship to LV remodeling.
American journal of physiology. Heart and circulatory physiology 2002;282(4):H1288-95.
2002: Francis G Spinale
Matrix metalloproteinases: regulation and dysregulation in the failing heart.
Circulation research 2002;90(5):520-30.
2002: William S Bradham; Biykem Bozkurt; Himali Gunasinghe; Douglas Mann; Francis G Spinale
Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: a current perspective.
Cardiovascular research 2002;53(4):822-30.
2002: David Schultz; Xuefeng Su; Chih-Chang Wei; Sanford P Bishop; Pamela C Powell; Gerald H Hankes; A Ray Dillon; Patricia Rynders; Francis G Spinale; Gregory P Walcott; Raymond Ideker; Louis J Dell'Italia
Downregulation of ANG II receptor is associated with compensated pressure-overload hypertrophy in the young dog.
American journal of physiology. Heart and circulatory physiology 2002;282(2):H749-56.
2001: SK Gunasinghe; John S Ikonomidis; Francis G Spinale
Contributory role of matrix metalloproteinases in cardiovascular remodeling.
Current drug targets. Cardiovascular & haematological disorders 2001;1(2):75-91.
2001: E M Wilson; Francis G Spinale
Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium.
Annals of medicine 2001;33(9):623-34.
2001: M Marlina Multani; R Stephen Krombach; Jennifer W Hendrick; SC Baicu; Cassandra Joffs; Jeffrey A Sample; M deGasparo; Francis G Spinale
Long-term angiotensin-converting enzyme and angiotensin I--receptor inhibition in pacing-induced heart failure: effects on myocardial interstitial bradykinin levels.
Journal of cardiac failure 2001;7(4):348-54.
2001: Adviye Ergul; Cassandra Joffs; A C Walker; Francis G Spinale
Potential role of endothelin receptor antagonists in the setting of cardiopulmonary bypass: relevance to myocardial performance.
Heart failure reviews 2001;6(4):287-94.
2001: M Marlina Multani; R Stephen Krombach; AT Goldberg; Mary K King; Jennifer W Hendrick; Jeffrey A Sample; SC Baicu; Cassandra Joffs; M deGasparo; Francis G Spinale
Myocardial bradykinin following acute angiotensin-converting enzyme inhibition, AT1 receptor blockade, or combined inhibition in congestive heart failure.
Journal of cardiovascular pharmacology and therapeutics 2001;6(4):369-76.
2001: David G Lucas; T Patterson; Jennifer W Hendrick; Jennifer Holder; Jeffrey A Sample; Cassandra Joffs; J Davis; A Goldberg; Rupak Mukherjee; Glenn Smits; Francis G Spinale
Effects of adenosine receptor subtype A1 on ventricular and renal function.
Journal of cardiovascular pharmacology 2001;38(4):618-24.
2001: T Etoh; Cassandra Joffs; Anne M Deschamps; J Davis; Kathryn B Dowdy; Jennifer W Hendrick; SC Baicu; Rupak Mukherjee; M Manhaini; Francis G Spinale
Myocardial and interstitial matrix metalloproteinase activity after acute myocardial infarction in pigs.
American journal of physiology. Heart and circulatory physiology 2001;281(3):H987-94.
2001: Natarajan Sivasubramanian; M L Coker; Karla M Kurrelmeyer; W R MacLellan; F J DeMayo; Francis G Spinale; Douglas L Mann
Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor.
Circulation 2001;104(7):826-31.
2001: Cassandra Joffs; CA Walker; Jennifer W Hendrick; D J Fary; Daniel K Almany; J N Davis; AT Goldberg; Fred A Crawford; Francis G Spinale
Endothelin receptor subtype A blockade selectively reduces pulmonary pressure after cardiopulmonary bypass.
The Journal of thoracic and cardiovascular surgery 2001;122(2):365-70.
2001: BR Bond; B Hugh Dorman; MJ Clair; CA Walker; ML Pinosky; Scott T Reeves; S Walton; John M Kratz; James L Zellner; Arthur J Crumbley; M Marlina Multani; Francis G Spinale
Endothelin-1 during and after cardiopulmonary bypass: association to graft sensitivity and postoperative recovery.
The Journal of thoracic and cardiovascular surgery 2001;122(2):358-64.
2001: Mytsi L Coker; J R Jolly; Cassandra Joffs; T Etoh; Jennifer Holder; BR Bond; Francis G Spinale
Matrix metalloproteinase expression and activity in isolated myocytes after neurohormonal stimulation.
American journal of physiology. Heart and circulatory physiology 2001;281(2):H543-51.
2001: James H McElmurray; Rupak Mukherjee; T M Patterson; Aaron Goldberg; Mary K King; Jennifer W Hendrick; DM Gay; MJ Clair; J R Jolly; Francis G Spinale
Comparison of amlodipine or nifedipine treatment with developing congestive heart failure: effects on myocyte contractility.
Journal of cardiac failure 2001;7(2):158-64.
2001: CA Walker; Adviye Ergul; Ashley L Grubbs; Michael R Zile; James L Zellner; Arthur J Crumbley; Francis G Spinale
beta-Adrenergic and endothelin receptor interaction in dilated human cardiomyopathic myocardium.
Journal of cardiac failure 2001;7(2):129-37.
2001: Tom Peterson; Hazem Hallak; L Johnson; H Li; PM O'Brien; Drago R Sliskovic; Thomas Bocan; Mytsi L Coker; T Etoh; Francis G Spinale
Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure.
Circulation 2001;103(18):2303-9.
2001: Cassandra Joffs; Himali Gunasinghe; M Marlina Multani; B Hugh Dorman; John M Kratz; Arthur J Crumbley; Fred A Crawford; Francis G Spinale
Cardiopulmonary bypass induces the synthesis and release of matrix metalloproteinases.
The Annals of thoracic surgery 2001;71(5):1518-23.
2001: Adviye Ergul; Ashley L Grubbs; Yuhua Zhang; Cassandra Joffs; Jeffrey A Sample; Mary K King; Francis G Spinale
Expression and activity of pulmonary endothelin converting enzyme in heart failure: relation to endothelin biosynthesis and receptor distribution.
Journal of cardiac failure 2001;7(1):84-91.
2001: Mary K King; DM Gay; L C Pan; James H McElmurray; Jennifer W Hendrick; Christine M Pirie; A Morrison; C Ding; Rupak Mukherjee; Francis G Spinale
Treatment with a growth hormone secretagogue in a model of developing heart failure: effects on ventricular and myocyte function.
Circulation 2001;103(2):308-13.
2000: Adviye Ergul; Ashley L Grubbs; Yuhua Zhang; Francis G Spinale
Selective upregulation of endothelin converting enzyme-1a in the human failing heart.
Journal of cardiac failure 2000;6(4):314-20.
2000: CA Walker; SC Baicu; AT Goldberg; C E Widener; D J Fary; Daniel K Almany; Adviye Ergul; Fred A Crawford; Francis G Spinale
Temporal endothelin dynamics of the myocardial interstitium and systemic circulation in cardiopulmonary bypass.
The Journal of thoracic and cardiovascular surgery 2000;120(5):864-71.
2000: Francis G Spinale; Mytsi L Coker; Lena J Heung; BR Bond; Himali Gunasinghe; T Etoh; AT Goldberg; James L Zellner; Arthur J Crumbley
A matrix metalloproteinase induction/activation system exists in the human left ventricular myocardium and is upregulated in heart failure.
Circulation 2000;102(16):1944-9.
2000: R Stephen Krombach; J H McElmuray; DM Gay; MJ Clair; Rupak Mukherjee; AT Goldberg; SC Baicu; Francis G Spinale
Bradykinin degradation and relation to myocyte contractility.
Journal of cardiovascular pharmacology and therapeutics 2000;5(4):291-9.
2000: B Hugh Dorman; BR Bond; MJ Clair; CA Walker; ML Pinosky; Scott T Reeves; John M Kratz; James L Zellner; Arthur J Crumbley; M Marlina Multani; Francis G Spinale
Temporal synthesis and release of endothelin within the systemic and myocardial circulation during and after cardiopulmonary bypass: relation to postoperative recovery.
Journal of cardiothoracic and vascular anesthesia 2000;14(5):540-5.
2000: RB New; AC Sampson; Mary K King; Jennifer W Hendrick; MJ Clair; James H McElmurray; J Mandel; Rupak Mukherjee; M de Gasparo; Francis G Spinale
Effects of combined angiotensin II and endothelin receptor blockade with developing heart failure: effects on left ventricular performance.
Circulation 2000;102(12):1447-53.
2000: Francis G Spinale
The effects of growth hormone supplementation on left ventricular function with the development of congestive heart failure.
Italian heart journal : official journal of the Italian Federation of Cardiology 2000;1 Suppl 3():S34-6.
2000: MJ Clair; Mary K King; AT Goldberg; Jennifer W Hendrick; R Nisato; DM Gay; A E Morrison; James H McElmurray; R Stephen Krombach; BR Bond; C Cazaubon; Dino Nisato; Francis G Spinale
Selective vasopressin, angiotensin II, or dual receptor blockade with developing congestive heart failure.
The Journal of pharmacology and experimental therapeutics 2000;293(3):852-60.
2000: Adviye Ergul; CA Walker; Aaron Goldberg; SC Baicu; Jennifer W Hendrick; Mary K King; Francis G Spinale
ET-1 in the myocardial interstitium: relation to myocyte ECE activity and expression.
American journal of physiology. Heart and circulatory physiology 2000;278(6):H2050-6.
2000: B Hugh Dorman; RB New; BR Bond; Rupak Mukherjee; Yurii V Mukhin; James H McElmurray; Francis G Spinale
Myocyte endothelin exposure during cardioplegic arrest exacerbates contractile dysfunction after reperfusion.
Anesthesia and analgesia 2000;90(5):1080-5.
2000: Francis G Spinale; Mytsi L Coker; BR Bond; James L Zellner
Myocardial matrix degradation and metalloproteinase activation in the failing heart: a potential therapeutic target.
Cardiovascular research 2000;46(2):225-38.
2000: BR Bond; James L Zellner; B Hugh Dorman; M Marlina Multani; John M Kratz; Arthur J Crumbley; Fred A Crawford; Francis G Spinale
Differential effects of calcium channel antagonists in the amelioration of radial artery vasospasm.
The Annals of thoracic surgery 2000;69(4):1035-40; discussion 1040-1.
2000: AT Goldberg; BR Bond; Rupak Mukherjee; RB New; James L Zellner; Fred A Crawford; Francis G Spinale
Endothelin receptor pathway in human left ventricular myocytes: relation to contractility.
The Annals of thoracic surgery 2000;69(3):711-5; discussion 716.
2000: B Hugh Dorman; Robert M Sade; J S Burnette; Henry B Wiles; ML Pinosky; Scott T Reeves; BR Bond; Francis G Spinale
Magnesium supplementation in the prevention of arrhythmias in pediatric patients undergoing surgery for congenital heart defects.
American heart journal 2000;139(3):522-8.
2000: M Nagatsu; Francis G Spinale; Masaaki Koide; H Tagawa; Gilberto Defreitas; George Cooper; Blase A Carabello
Bradycardia and the role of beta-blockade in the amelioration of left ventricular dysfunction.
Circulation 2000;101(6):653-9.
2000: CA Walker; Fred A Crawford; Francis G Spinale
Myocyte contractile dysfunction with hypertrophy and failure: relevance to cardiac surgery.
The Journal of thoracic and cardiovascular surgery 2000;119(2):388-400.
2000: Francis G Spinale; David G Lucas
Surgical options for the treatment of heart failure.
Clinical cornerstone 2000;3(2):45-56.
2000: S N Caparas; MJ Clair; R Stephen Krombach; Jennifer W Hendrick; WV Houck; SB Kribbs; Rupak Mukherjee; George E Tempel; Francis G Spinale
Brain blood flow patterns after the development of congestive heart failure: effects of treadmill exercise.
Critical care medicine 2000;28(1):209-14.
2000: L Roten; Shintaro Nemoto; Janet M Simsic; Mytsi L Coker; V Rao; S Baicu; G DeFreyte; P J Soloway; Michael R Zile; Francis G Spinale
Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice.
Journal of molecular and cellular cardiology 2000;32(1):109-20.
2000: Y Nagatomo; Blase A Carabello; Mytsi L Coker; Paul J McDermott; Shintaro Nemoto; Masayoshi Hamawaki; Francis G Spinale
Differential effects of pressure or volume overload on myocardial MMP levels and inhibitory control.
American journal of physiology. Heart and circulatory physiology 2000;278(1):H151-61.
1999: Seshadri Balaji; Kenneth W Hewett; R Stephen Krombach; MJ Clair; Xiaobu Ye; Francis G Spinale
Inducible lethal ventricular arrhythmias in swine with pacing-induced heart failure.
Basic research in cardiology 1999;94(6):496-503.
1999: WV Houck; L C Pan; SB Kribbs; MJ Clair; G M McDaniel; R Stephen Krombach; W M Merritt; Christine M Pirie; JP Iannini; Rupak Mukherjee; Francis G Spinale
Effects of growth hormone supplementation on left ventricular morphology and myocyte function with the development of congestive heart failure.
Circulation 1999;100(19):2003-9.
1999: Francis G Spinale
Cellular and molecular therapeutic targets for treatment of contractile dysfunction after cardioplegic arrest.
The Annals of thoracic surgery 1999;68(5):1934-41.
1999: James A. Loging; RB New; SC Baicu; Mary K King; Jennifer W Hendrick; Fred A Crawford; M de Gasparo; Francis G Spinale
Effects of angiotensin type-I receptor blockade on pericardial fibrosis.
The Journal of surgical research 1999;87(1):101-7.
1999: James H McElmurray; Rupak Mukherjee; RB New; AC Sampson; Mary K King; Jennifer W Hendrick; Aaron Goldberg; T J Peterson; Hazem Hallak; Michael R Zile; Francis G Spinale
Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: comparative effects on left ventricular function and geometry.
The Journal of pharmacology and experimental therapeutics 1999;291(2):799-811.
1999: Francis G Spinale; Mytsi L Coker; S R Krombach; Rupak Mukherjee; Hazem Hallak; WV Houck; MJ Clair; SB Kribbs; L L Johnson; Tom Peterson; Michael R Zile
Matrix metalloproteinase inhibition during the development of congestive heart failure : effects on left ventricular dimensions and function.
Circulation research 1999;85(4):364-76.
1999: R Stephen Krombach; MJ Clair; Jennifer W Hendrick; Rupak Mukherjee; WV Houck; Latha Hebbar; SB Kribbs; MG Dodd; Francis G Spinale
Amlodipine therapy in congestive heart failure: hemodynamic and neurohormonal effects at rest and after treadmill exercise.
The American journal of cardiology 1999;84(4A):3L-15L.
1999: Mytsi L Coker; MA Doscher; CV Thomas; Zorina Galis; Francis G Spinale
Matrix metalloproteinase synthesis and expression in isolated LV myocyte preparations.
The American journal of physiology 1999;277(2 Pt 2):H777-87.
1999: CA Walker; Francis G Spinale
The structure and function of the cardiac myocyte: a review of fundamental concepts.
The Journal of thoracic and cardiovascular surgery 1999;118(2):375-82.
1999: Mytsi L Coker; James L Zellner; Arthur J Crumbley; Francis G Spinale
Defects in matrix metalloproteinase inhibitory stoichiometry and selective MMP induction in patients with nonischemic or ischemic dilated cardiomyopathy.
Annals of the New York Academy of Sciences 1999;878():559-62.
1999: Vijay U Rao; Francis G Spinale
Controlling myocardial matrix remodeling: implications for heart failure.
Cardiology in review 1999;7(3):136-43.
1999: Francis G Spinale
Novel approaches to retard ventricular remodeling in heart failure.
European journal of heart failure 1999;1(1):17-23.
1998: Francis G Spinale; JP Iannini; Rupak Mukherjee; DM Melton; M de Gasparo
Angiotensin AT1 receptor inhibition, angiotensin-converting enzyme inhibition, and combination therapy with developing heart failure: cellular mechanisms of action.
Journal of cardiac failure 1998;4(4):325-32.
1998: MJ Clair; R Stephen Krombach; Jennifer W Hendrick; WV Houck; Latha Hebbar; SB Kribbs; GA Rios; S Whitebread; Rupak Mukherjee; M de Gasparo; Francis G Spinale
AT1 angiotensin II receptor inhibition in pacing-induced heart failure: effects on left ventricular performance and regional blood flow patterns.
Journal of cardiac failure 1998;4(4):311-23.
1998: CV Thomas; G M McDaniel; Henry H Holzgrefe; Rupak Mukherjee; Robert Hird; JD Walker; Latha Hebbar; James R Powell; Francis G Spinale
Chronic dual inhibition of angiotensin-converting enzyme and neutral endopeptidase during the development of left ventricular dysfunction in dogs.
Journal of cardiovascular pharmacology 1998;32(6):902-12.
1998: D Saad; Rupak Mukherjee; Patrick B Thomas; JP Iannini; CG Basler; Latha Hebbar; Seung-Jun O; Suzanne Moreland; Maria L Webb; James R Powell; Francis G Spinale
The effects of endothelin-A receptor blockade during the progression of pacing-induced congestive heart failure.
Journal of the American College of Cardiology 1998;32(6):1779-86.
1998: B Hugh Dorman; Latha Hebbar; James L Zellner; RB New; WV Houck; Jeffrey R Acsell; C Nettles; Jennifer W Hendrick; Tony Sampson; Rupak Mukherjee; Francis G Spinale
ATP-sensitive potassium channel activation before cardioplegia. Effects on ventricular and myocyte function.
Circulation 1998;98(19 Suppl):II176-83.
1998: MJ Clair; R Stephen Krombach; Mytsi L Coker; T L Heslin; SB Kribbs; M de Gasparo; Francis G Spinale
Angiotensin AT1 receptor inhibition in pacing induced heart failure: effects on left ventricular myocardial collagen content and composition.
Journal of molecular and cellular cardiology 1998;30(11):2355-64.
1998: D L Mann; Francis G Spinale
Activation of matrix metalloproteinases in the failing human heart: breaking the tie that binds.
Circulation 1998;98(17):1699-702.
1998: Francis G Spinale; Rupak Mukherjee; R Stephen Krombach; MJ Clair; Jennifer W Hendrick; WV Houck; Latha Hebbar; SB Kribbs; James L Zellner; MG Dodd
Chronic amlodipine treatment during the development of heart failure.
Circulation 1998;98(16):1666-74.
1998: Rupak Mukherjee; Francis G Spinale
L-type calcium channel abundance and function with cardiac hypertrophy and failure: a review.
Journal of molecular and cellular cardiology 1998;30(10):1899-916.
1998: RB New; James L Zellner; Latha Hebbar; Rupak Mukherjee; AC Sampson; Jennifer W Hendrick; John R Handy; Fred A Crawford; Francis G Spinale
Isolated left ventricular myocyte contractility in patients undergoing cardiac operations.
The Journal of thoracic and cardiovascular surgery 1998;116(3):495-502.
1998: James L Zellner; SB Kribbs; B Hugh Dorman; Francis G Spinale
Cardiopulmonary bypass in a gravid patient: perioperative changes in endothelin levels.
The Annals of thoracic surgery 1998;66(1):268-70.
1998: R Stephen Krombach; MJ Clair; Jennifer W Hendrick; WV Houck; James L Zellner; SB Kribbs; S Whitebread; Rupak Mukherjee; M de Gasparo; Francis G Spinale
Angiotensin converting enzyme inhibition, AT1 receptor inhibition, and combination therapy with pacing induced heart failure: effects on left ventricular performance and regional blood flow patterns.
Cardiovascular research 1998;38(3):631-45.
1998: CV Thomas; Mytsi L Coker; James L Zellner; John R Handy; Arthur J Crumbley; Francis G Spinale
Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy.
Circulation 1998;97(17):1708-15.
1998: Mytsi L Coker; CV Thomas; MJ Clair; Jennifer W Hendrick; R Stephen Krombach; Zorina Galis; Francis G Spinale
Myocardial matrix metalloproteinase activity and abundance with congestive heart failure.
The American journal of physiology 1998;274(5 Pt 2):H1516-23.
1998: WV Houck; SB Kribbs; James L Zellner; MA Doscher; JD Joshi; Fred A Crawford; Francis G Spinale
Normothermic versus hypothermic hyperkalemic cardioplegia: effects on myocyte contractility.
The Annals of thoracic surgery 1998;65(5):1279-83.
1998: Biykem Bozkurt; S B Kribbs; F J Clubb; L H Michael; Vladimir V Didenko; Peter J Hornsby; Y Seta; Hakan Oral; Francis G Spinale; Douglas L Mann
Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats.
Circulation 1998;97(14):1382-91.
1998: Latha Hebbar; WV Houck; James L Zellner; B Hugh Dorman; Francis G Spinale
Temporal relation of ATP-sensitive potassium-channel activation and contractility before cardioplegia.
The Annals of thoracic surgery 1998;65(4):1077-82.
1998: Francis G Spinale; Mytsi L Coker; CV Thomas; JD Walker; Rupak Mukherjee; Latha Hebbar
Time-dependent changes in matrix metalloproteinase activity and expression during the progression of congestive heart failure: relation to ventricular and myocyte function.
Circulation research 1998;82(4):482-95.
1998: SB Kribbs; W M Merritt; MJ Clair; R Stephen Krombach; WV Houck; MG Dodd; Rupak Mukherjee; Francis G Spinale
Amlodipine monotherapy, angiotensin-converting enzyme inhibition, and combination therapy with pacing-induced heart failure.
Hypertension 1998;31(3):755-65.
1998: Rupak Mukherjee; Kenneth W Hewett; JD Walker; CG Basler; Francis G Spinale
Changes in L-type calcium channel abundance and function during the transition to pacing-induced congestive heart failure.
Cardiovascular research 1998;37(2):432-44.
1998: Diane M Eble; J D Walker; Allen M Samarel; Francis G Spinale
Myosin heavy chain synthesis during the progression of chronic tachycardia induced heart failure in rabbits.
Basic research in cardiology 1998;93(1):50-5.
1998: WV Houck; CV Thomas; MA Doscher; Y H Wang; Latha Hebbar; JD Joshi; Rupak Mukherjee; Fred A Crawford; Francis G Spinale
Downstream defects in beta-adrenergic signaling and relation to myocyte contractility after cardioplegic arrest.
The Journal of thoracic and cardiovascular surgery 1998;115(1):190-9.
1997: SB Kribbs; MJ Clair; R Stephen Krombach; Jennifer W Hendrick; Patrick B Thomas; A T Keever; W V Houch; Rupak Mukherjee; Francis G Spinale
Pulmonary hemodynamics and endothelin levels in pacing-induced heart failure: during rest and exercise.
Journal of cardiac failure 1997;3(4):263-70.
1997: K R Hedgepath; Rupak Mukherjee; Z Wang; Francis G Spinale
The relation between changes in myocyte orientation and contractile function with electrical field stimulation.
Basic research in cardiology 1997;92(6):385-90.
1997: Francis G Spinale; Henry H Holzgrefe; Rupak Mukherjee; Maria L Webb; Robert Hird; M J Cavallo; James R Powell; W H Koster
Angiotensin-converting enzyme inhibition and angiotensin II subtype-1 receptor blockade during the progression of left ventricular dysfunction: differential effects on myocyte contractile processes.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1082-94.
1997: B Hugh Dorman; Latha Hebbar; MJ Clair; RB Hinton; RC Roy; Francis G Spinale
Potassium channel opener-augmented cardioplegia: protection of myocyte contractility with chronic left ventricular dysfunction.
Circulation 1997;96(9 Suppl):II-253-9.
1997: Francis G Spinale; Henry H Holzgrefe; JD Walker; Rupak Mukherjee; SB Kribbs; James R Powell; M Antonaccio
Angiotensin II subtype-1 receptor blockade during the development of left ventricular hypertrophy in dogs: effects on ventricular and myocyte function.
Journal of cardiovascular pharmacology 1997;30(5):623-31.
1997: Francis G Spinale; Rupak Mukherjee; JP Iannini; S Whitebread; Latha Hebbar; MJ Clair; DM Melton; Monty H Cox; Patrick B Thomas; M de Gasparo
Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: II. Effects on myocyte contractile processes.
Circulation 1997;96(7):2397-406.
1997: Francis G Spinale; M de Gasparo; S Whitebread; Latha Hebbar; MJ Clair; DM Melton; R Stephen Krombach; Rupak Mukherjee; JP Iannini; Seung-Jun O
Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: I. Effects on left ventricular performance and neurohormonal systems.
Circulation 1997;96(7):2385-96.
1997: B Hugh Dorman; Latha Hebbar; RB Hinton; RC Roy; Francis G Spinale
Preservation of myocyte contractile function after hyperthermic cardioplegic arrest by activation of ATP-sensitive potassium channels.
Circulation 1997;96(7):2376-84.
1997: Seung-Jun O; Monty H Cox; Fred A Crawford; Francis G Spinale
Protein kinase C activation before cardioplegic arrest: beneficial effects on myocyte contractility.
The Journal of thoracic and cardiovascular surgery 1997;114(4):651-9.
1997: ML Pinosky; D J Kennedy; R L Fishman; Scott T Reeves; Calvert C. Alpert; J Ecklund; SB Kribbs; Francis G Spinale; John M Kratz; R Crawford; G P Gravlee; B Hugh Dorman
Tranexamic acid reduces bleeding after cardiopulmonary bypass when compared to epsilon aminocaproic acid and placebo.
Journal of cardiac surgery 1997;12(5):330-8.
1997: JD Walker; John M Kratz; CG Basler; L P Meck; J R Stratton; SB Kribbs; Fred A Crawford; Francis G Spinale
Fate of gelatin-resorcinol-formaldehyde/glutaraldeyde adhesive on femoral vessel morphology.
The Journal of surgical research 1997;71(1):73-8.
1997: Z Wang; CF Lam; Rupak Mukherjee; Latha Hebbar; Y Wang; Francis G Spinale
Relationship between external load and isolated myocyte contractile function with CHF in pigs.
The American journal of physiology 1997;273(1 Pt 2):H183-91.
1997: RB Hinton; Latha Hebbar; Monty H Cox; Rupak Mukherjee; JD Joshi; Fred A Crawford; Francis G Spinale
Left ventricular regional myocyte contractility in normal and heart failure states.
Journal of molecular and cellular cardiology 1997;29(7):1939-46.
1997: Monty H Cox; Seung-Jun O; M de Gasparo; Rupak Mukherjee; Kenneth W Hewett; Francis G Spinale
Myocardial electrophysiological properties in the presence of an AT1 angiotensin II receptor antagonist.
Basic research in cardiology 1997;92(3):129-38.
1997: Monty H Cox; Seung-Jun O; Latha Hebbar; Rupak Mukherjee; Fred A Crawford; Francis G Spinale
Protective effects of adenosine on myocyte contractility during cardioplegic arrest.
The Annals of thoracic surgery 1997;63(4):981-7.
1997: Francis G Spinale; J D Walker; Rupak Mukherjee; JP Iannini; A T Keever; K P Gallagher
Concomitant endothelin receptor subtype-A blockade during the progression of pacing-induced congestive heart failure in rabbits. Beneficial effects on left ventricular and myocyte function.
Circulation 1997;95(7):1918-29.
1997: Monty H Cox; Seung-Jun O; MJ Clair; Rupak Mukherjee; Thomas W Wakefield; Philip C Andrews; James C Stanley; Fred A Crawford; Francis G Spinale
Differential effects of novel protamine variants on myocyte contractile function with left ventricular failure.
Surgery 1997;121(3):304-13.
1997: Latha Hebbar; B Hugh Dorman; MJ Clair; RC Roy; Francis G Spinale
Negative and selective effects of propofol on isolated swine myocyte contractile function in pacing-induced congestive heart failure.
Anesthesiology 1997;86(3):649-59.
1997: DM Melton; Henry H Holzgrefe; JD Walker; Rupak Mukherjee; Susan R Arthur; M J Antonaccio; W H Koster; Francis G Spinale
Effects of chronic angiotensin-converting enzyme inhibition on left ventricular and myocyte structure and function during recovery from chronic rapid pacing.
Journal of molecular and cellular cardiology 1997;29(2):697-710.
1997: Diane M Eble; J D Walker; Rupak Mukherjee; Allen M Samarel; Francis G Spinale
Myosin heavy chain synthesis is increased in a rabbit model of heart failure.
The American journal of physiology 1997;272(2 Pt 2):H969-78.
1996: Patrick B Thomas; E C Liu; Maria L Webb; Rupak Mukherjee; Latha Hebbar; Francis G Spinale
Exogenous effects and endogenous production of endothelin in cardiac myocytes: potential significance in heart failure.
The American journal of physiology 1996;271(6 Pt 2):H2629-37.
1996: Francis G Spinale; W S Johnson; Y Wang; Z Wang; Rupak Mukherjee; Latha Hebbar; B U Jones
Direct effects of chronic beta-adrenergic receptor blockade on left ventricular and myocyte function in a model of tachycardia-induced congestive heart failure.
Journal of cardiac failure 1996;2(4):311-8.
1996: JP Iannini; Francis G Spinale
The identification of contributory mechanisms for the development and progression of congestive heart failure in animal models.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1996;15(11):1138-50.
1996: Seung-Jun O; James L Zellner; Monty H Cox; Latha Hebbar; Thomas E Brothers; Rupak Mukherjee; George E Tempel; B Hugh Dorman; Fred A Crawford; Francis G Spinale
Contributory mechanisms for the beneficial effects of myocyte preconditioning during cardioplegic arrest.
Circulation 1996;94(9 Suppl):II389-97.
1996: Latha Hebbar; B Hugh Dorman; RC Roy; Francis G Spinale
The direct effects of propofol on myocyte contractile function after hypothermic cardioplegic arrest.
Anesthesia and analgesia 1996;83(5):949-57.
1996: John R Handy; B Hugh Dorman; M J Cavallo; R B Hinton; RC Roy; Fred A Crawford; Francis G Spinale
Direct effects of oxygenated crystalloid or blood cardioplegia on isolated myocyte contractile function.
The Journal of thoracic and cardiovascular surgery 1996;112(4):1064-72.
1996: Francis G Spinale; James L Zellner; W S Johnson; Diane M Eble; P D Munyer
Cellular and extracellular remodeling with the development and recovery from tachycardia-induced cardiomyopathy: changes in fibrillar collagen, myocyte adhesion capacity and proteoglycans.
Journal of molecular and cellular cardiology 1996;28(8):1591-608.
1996: W S McMahon; Henry H Holzgrefe; JD Walker; Rupak Mukherjee; S R Arthur; M J Cavallo; M J Child; Francis G Spinale
Cellular basis for improved left ventricular pump function after digoxin therapy in experimental left ventricular failure.
Journal of the American College of Cardiology 1996;28(2):495-505.
1996: Seung-Jun O; Monty H Cox; Rupak Mukherjee; MJ Clair; Fred A Crawford; Francis G Spinale
Direct and interactive effects of cardioplegic arrest and protamine on myocyte contractility.
The Annals of thoracic surgery 1996;62(2):489-94.
1996: Carolyn E Reed; B Hugh Dorman; Francis G Spinale
Mechanisms of right ventricular dysfunction after pulmonary resection.
The Annals of thoracic surgery 1996;62(1):225-31; discussion 231-2.
1996: Søren B Hansen; AD Slater; C A Rodriguez; Francis G Spinale; William P Santamore
Examination of epimysial leads used to stimulate the latissimus dorsi muscle.
IEEE transactions on bio-medical engineering 1996;43(6):653-7.
1996: W S McMahon; PC Gillette; R B Hinton; J R Stratton; Fred A Crawford; Francis G Spinale
Developmental differences in myocyte contractile response after cardioplegic arrest.
The Journal of thoracic and cardiovascular surgery 1996;111(6):1257-66.
1996: B Hugh Dorman; M J Cavallo; R B Hinton; RC Roy; Francis G Spinale
Preservation of myocyte contractile function after hypothermic, hyperkalemic cardioplegic arrest with 2, 3-butanedione monoxime.
The Journal of thoracic and cardiovascular surgery 1996;111(3):621-9.
1996: Z Wang; Rupak Mukherjee; CF Lam; Francis G Spinale
Spatial characterization of contracting cardiac myocytes by computer-assisted, video-based image processing.
The American journal of physiology 1996;270(2 Pt 2):H769-79.
1996: W S McMahon; Rupak Mukherjee; PC Gillette; Fred A Crawford; Francis G Spinale
Right and left ventricular geometry and myocyte contractile processes with dilated cardiomyopathy: myocyte growth and beta-adrenergic responsiveness.
Cardiovascular research 1996;31(2):314-23.
1996: James L Zellner; Latha Hebbar; Fred A Crawford; Rupak Mukherjee; Francis G Spinale
Beneficial effects of myocyte preconditioning on contractile processes after cardioplegic arrest.
The Annals of thoracic surgery 1996;61(2):558-64.
1996: John D Mannion; V Blood; W Bailey; T L Bauer; M G Magno; F DiMeo; A Epple; Francis G Spinale
The effect of basic fibroblast growth factor on the blood flow and morphologic features of a latissimus dorsi cardiomyoplasty.
The Journal of thoracic and cardiovascular surgery 1996;111(1):19-28.
1995: Robert Hird; Thomas W Wakefield; Rupak Mukherjee; B U Jones; Fred A Crawford; Philip C Andrews; James C Stanley; Francis G Spinale
Direct effects of protamine sulfate on myocyte contractile processes. Cellular and molecular mechanisms.
Circulation 1995;92(9 Suppl):II433-46.
1995: B Hugh Dorman; M J Cavallo; RC Roy; Francis G Spinale
The direct and interactive effects of phosphodiesterase inhibition and beta-adrenergic stimulation on myocyte contractile function after hypothermic cardioplegic arrest.
Anesthesia and analgesia 1995;81(5):925-31.
1995: JD Walker; Fred A Crawford; Rupak Mukherjee; Francis G Spinale
The direct effects of 3,5,3'-triiodo-L-thyronine (T3) on myocyte contractile processes. Insights into mechanisms of action.
The Journal of thoracic and cardiovascular surgery 1995;110(5):1369-79; discussion 1379-80.
1995: B Hugh Dorman; Bruce M Elliott; Francis G Spinale; MK Bailey; J. Scott Walton; Jacob G Robison; Thomas E Brothers; M H Cook
Protamine use during peripheral vascular surgery: a prospective randomized trial.
Journal of vascular surgery 1995;22(3):248-55; discussion 256.
1995: S Kato; Francis G Spinale; R Tanaka; W Johnson; George Cooper; Michael R Zile
Inhibition of collagen cross-linking: effects on fibrillar collagen and ventricular diastolic function.
The American journal of physiology 1995;269(3 Pt 2):H863-8.
1995: Francis G Spinale
1988: Comparison of bioimpedance and thermodilution methods for determining cardiac output: experimental and clinical studies. Updated in 1995.
The Annals of thoracic surgery 1995;60(2):483-4.
1995: JD Walker; Fred A Crawford; Francis G Spinale
3,5,3' Triiodo-L-thyronine pretreatment with cardioplegic arrest and chronic left ventricular dysfunction.
The Annals of thoracic surgery 1995;60(2):292-9.
1995: JD Walker; Fred A Crawford; Francis G Spinale
Pretreatment with 3,5,3'triiodo-L-thyronine (T3). Effects on myocyte contractile function after hypothermic cardioplegic arrest and rewarming.
The Journal of thoracic and cardiovascular surgery 1995;110(2):315-27.
1995: Francis G Spinale; Henry H Holzgrefe; Rupak Mukherjee; Robert Hird; JD Walker; A Arnim-Barker; James R Powell; W H Koster
Angiotensin-converting enzyme inhibition and the progression of congestive cardiomyopathy. Effects on left ventricular and myocyte structure and function.
Circulation 1995;92(3):562-78.
1995: Rupak Mukherjee; Kenneth W Hewett; Francis G Spinale
Myocyte electrophysiological properties following the development of supraventricular tachycardia-induced cardiomyopathy.
Journal of molecular and cellular cardiology 1995;27(6):1333-48.
1995: Diane M Eble; Francis G Spinale
Contractile and cytoskeletal content, structure, and mRNA levels with tachycardia-induced cardiomyopathy.
The American journal of physiology 1995;268(6 Pt 2):H2426-39.
1995: Michael R Zile; Rupak Mukherjee; C Clayton; S Kato; Francis G Spinale
Effects of chronic supraventricular pacing tachycardia on relaxation rate in isolated cardiac muscle cells.
The American journal of physiology 1995;268(5 Pt 2):H2104-13.
1995: M J Cavallo; B Hugh Dorman; Francis G Spinale; RC Roy
Myocyte contractile responsiveness after hypothermic, hyperkalemic cardioplegic arrest. Disparity between exogenous calcium and beta-adrenergic stimulation.
Anesthesiology 1995;82(4):926-39.
1995: Robert Hird; Fred A Crawford; Francis G Spinale
Differential effects of protamine sulfate on myocyte contractile function with left ventricular failure.
Journal of the American College of Cardiology 1995;25(3):773-80.
1995: Francis G Spinale; Henry H Holzgrefe; Rupak Mukherjee; S R Arthur; M J Child; James R Powell; W H Koster
LV and myocyte structure and function after early recovery from tachycardia-induced cardiomyopathy.
The American journal of physiology 1995;268(2 Pt 2):H836-47.
1995: Robert Hird; Fred A Crawford; Rupak Mukherjee; Francis G Spinale
Direct effects of thrombin on myocyte contractile function.
The Annals of thoracic surgery 1995;59(2):288-93.
1994: Robert Hird; Francis G Spinale; Kenneth W Hewett; Rupak Mukherjee; Fred A Crawford
The direct effects of protamine sulfate on myocyte contractile processes.
The Journal of thoracic and cardiovascular surgery 1994;108(6):1100-14.
1994: JD Walker; Fred A Crawford; S Kato; Francis G Spinale
The novel effects of 3,5,3'-triiodo-L-thyronine on myocyte contractile function and beta-adrenergic responsiveness in dilated cardiomyopathy.
The Journal of thoracic and cardiovascular surgery 1994;108(4):672-9.
1994: D E Burkett; AA Seymour; D H Knight; C E Rabon; V M Lanoce; A F Clemons; Francis G Spinale
Myocardial effects of repetitive episodes of rapid ventricular pacing in conscious dogs: surgical creation, echocardiographic evaluation, and morphometric analysis.
Laboratory animal science 1994;44(5):453-61.
1994: JD Walker; Fred A Crawford; Rupak Mukherjee; Michael R Zile; Francis G Spinale
Direct effects of acute administration of 3, 5, 3' triiodo-L-thyronine on myocyte function.
The Annals of thoracic surgery 1994;58(3):851-6.
1994: Francis G Spinale; Diane M Eble; Rupak Mukherjee; W S Johnson; J D Walker
Left ventricular and myocyte structure and function following chronic ventricular tachycardia in rabbits.
Basic research in cardiology 1994;89(5):456-67.
1994: Francis G Spinale; George E Tempel; Rupak Mukherjee; Diane M Eble; R Brown; C A Vacchiano; Michael R Zile
Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia.
Cardiovascular research 1994;28(8):1243-50.
1994: H Tsutsui; Francis G Spinale; M Nagatsu; P G Schmid; K Ishihara; G DeFreyte; George Cooper; Blase A Carabello
Effects of chronic beta-adrenergic blockade on the left ventricular and cardiocyte abnormalities of chronic canine mitral regurgitation.
The Journal of clinical investigation 1994;93(6):2639-48.
1994: Robert Hird; Fred A Crawford; Rupak Mukherjee; Michael R Zile; Francis G Spinale
Effects of protamine on myocyte contractile function and beta-adrenergic responsiveness.
The Annals of thoracic surgery 1994;57(5):1066-74; discussion 1074-5.
1994: John R Handy; Francis G Spinale; Rupak Mukherjee; Fred A Crawford
Hypothermic potassium cardioplegia impairs myocyte recovery of contractility and inotropy.
The Journal of thoracic and cardiovascular surgery 1994;107(4):1050-8.
1994: John M Kratz; W S Johnson; Rupak Mukherjee; J Hu; Fred A Crawford; Francis G Spinale
The relation between latissimus dorsi skeletal muscle structure and contractile function after cardiomyoplasty.
The Journal of thoracic and cardiovascular surgery 1994;107(3):868-78.
1993: Francis G Spinale; K Ishihra; Michael R Zile; G DeFryte; Fred A Crawford; Blase A Carabello
Structural basis for changes in left ventricular function and geometry because of chronic mitral regurgitation and after correction of volume overload.
The Journal of thoracic and cardiovascular surgery 1993;106(6):1147-57.
1993: R Tanaka; B M Fulbright; Rupak Mukherjee; S A Burchell; Fred A Crawford; Michael R Zile; Francis G Spinale
The cellular basis for the blunted response to beta-adrenergic stimulation in supraventricular tachycardia-induced cardiomyopathy.
Journal of molecular and cellular cardiology 1993;25(10):1215-33.
1993: R G Sutton; John M Kratz; Francis G Spinale; Fred A Crawford
Comparison of three blood-processing techniques during and after cardiopulmonary bypass.
The Annals of thoracic surgery 1993;56(4):938-43.
1993: Carolyn E Reed; B Hugh Dorman; Francis G Spinale
Assessment of right ventricular contractile performance after pulmonary resection.
The Annals of thoracic surgery 1993;56(3):426-31; discussion 431-2.
1993: Y Urabe; Y Hamada; Francis G Spinale; Blase A Carabello; R L Kent; George Cooper; D L Mann
Cardiocyte contractile performance in experimental biventricular volume-overload hypertrophy.
The American journal of physiology 1993;264(5 Pt 2):H1615-23.
1993: Rupak Mukherjee; Fred A Crawford; Kenneth W Hewett; Francis G Spinale
Cell and sarcomere contractile performance from the same cardiocyte using video microscopy.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(4):2023-33.
1993: W Cheng; J J Michele; Francis G Spinale; J D Sink; W P Santamore
Effects of cardiomyoplasty on biventricular function in canine chronic heart failure.
The Annals of thoracic surgery 1993;55(4):893-901.
1993: B Hugh Dorman; Francis G Spinale; MK Bailey; John M Kratz; RC Roy
Identification of patients at risk for excessive blood loss during coronary artery bypass surgery: thromboelastography versus coagulation screen.
Anesthesia and analgesia 1993;76(4):694-700.
1993: Michael R Zile; M Tomita; K Ishihara; K Nakano; J Lindroth; Francis G Spinale; M Michael Swindle; Blase A Carabello
Changes in diastolic function during development and correction of chronic LV volume overload produced by mitral regurgitation.
Circulation 1993;87(4):1378-88.
1993: Francis G Spinale; Rupak Mukherjee; B M Fulbright; J Hu; Fred A Crawford; Michael R Zile
Contractile properties of isolated porcine ventricular myocytes.
Cardiovascular research 1993;27(2):304-11.
1992: B Hugh Dorman; Francis G Spinale; John M Kratz; Calvert C. Alpert; M Ford
Use of a combined right ventricular ejection fraction-oximetry catheter system for coronary bypass surgery.
Critical care medicine 1992;20(12):1650-6.
1992: R Tanaka; Francis G Spinale; Fred A Crawford; Michael R Zile
Effect of chronic supraventricular tachycardia on left ventricular function and structure in newborn pigs.
Journal of the American College of Cardiology 1992;20(7):1650-60.
1992: Michael R Zile; R Tanaka; J R Lindroth; Francis G Spinale; Blase A Carabello; I Mirsky
Left ventricular volume determined echocardiographically by assuming a constant left ventricular epicardial long-axis/short-axis dimension ratio throughout the cardiac cycle.
Journal of the American College of Cardiology 1992;20(4):986-93.
1992: S A Burchell; Francis G Spinale; Fred A Crawford; R Tanaka; Michael R Zile
Effects of chronic tachycardia-induced cardiomyopathy on the beta-adrenergic receptor system.
The Journal of thoracic and cardiovascular surgery 1992;104(4):1006-12.
1992: E C Douville; John M Kratz; Francis G Spinale; Fred A Crawford; Calvert C. Alpert; A Pearce
Retrograde versus antegrade cardioplegia: impact on right ventricular function.
The Annals of thoracic surgery 1992;54(1):56-61.
1992: Francis G Spinale; B M Fulbright; Rupak Mukherjee; R Tanaka; J Hu; Fred A Crawford; Michael R Zile
Relation between ventricular and myocyte function with tachycardia-induced cardiomyopathy.
Circulation research 1992;71(1):174-87.
1992: Carolyn E Reed; Francis G Spinale; Fred A Crawford
Effect of pulmonary resection on right ventricular function.
The Annals of thoracic surgery 1992;53(4):578-82.
1992: Francis G Spinale; Rupak Mukherjee; R Tanaka; Michael R Zile
The effects of valvular regurgitation on thermodilution ejection fraction measurements.
Chest 1992;101(3):723-31.
1992: Francis G Spinale; C Clayton; R Tanaka; B M Fulbright; Rupak Mukherjee; Bradley A Schulte; Fred A Crawford; Michael R Zile
Myocardial Na+,K(+)-ATPase in tachycardia induced cardiomyopathy.
Journal of molecular and cellular cardiology 1992;24(3):277-94.
1992: Francis G Spinale; R Tanaka; Fred A Crawford; Michael R Zile
Changes in myocardial blood flow during development of and recovery from tachycardia-induced cardiomyopathy.
Circulation 1992;85(2):717-29.
1992: Francis G Spinale; R C Grine; George E Tempel; Fred A Crawford; Michael R Zile
Alterations in the myocardial capillary vasculature accompany tachycardia-induced cardiomyopathy.
Basic research in cardiology 1992;87(1):65-79.
1991: Francis G Spinale; Fred A Crawford; Kenneth W Hewett; Blase A Carabello
Ventricular failure and cellular remodeling with chronic supraventricular tachycardia.
The Journal of thoracic and cardiovascular surgery 1991;102(6):874-82.
1991: Francis G Spinale; James L Zellner; M Tomita; Fred A Crawford; Michael R Zile
Relation between ventricular and myocyte remodeling with the development and regression of supraventricular tachycardia-induced cardiomyopathy.
Circulation research 1991;69(4):1058-67.
1991: James L Zellner; Francis G Spinale; Diane M Eble; Kenneth W Hewett; Fred A Crawford
Alterations in myocyte shape and basement membrane attachment with tachycardia-induced heart failure.
Circulation research 1991;69(3):590-600.
1991: Francis G Spinale; M Tomita; James L Zellner; J C Cook; Fred A Crawford; Michael R Zile
Collagen remodeling and changes in LV function during development and recovery from supraventricular tachycardia.
The American journal of physiology 1991;261(2 Pt 2):H308-18.
1991: Francis G Spinale; James L Zellner; M Tomita; George E Tempel; Fred A Crawford; Michael R Zile
Tachycardia-induced cardiomyopathy: effects on blood flow and capillary structure.
The American journal of physiology 1991;261(1 Pt 2):H140-8.
1991: D L Trippel; M E Harold; Francis G Spinale; D S Buckles; PC Gillette
The acute effects of flecainide in the swine heart failing from incessant supraventricular tachycardia.
American heart journal 1991;121(6 Pt 1):1721-6.
1991: K Nakano; M Michael Swindle; Francis G Spinale; K Ishihara; S Kanazawa; Alison C Smith; R W Biederman; L Clamp; Y Hamada; Michael R Zile
Depressed contractile function due to canine mitral regurgitation improves after correction of the volume overload.
The Journal of clinical investigation 1991;87(6):2077-86.
1991: Alison C Smith; James L Zellner; Francis G Spinale; M Michael Swindle
Sedative and cardiovascular effects of midazolam in swine.
Laboratory animal science 1991;41(2):157-61.
1991: Francis G Spinale; James L Zellner; Rupak Mukherjee; Fred A Crawford
Placement considerations for measuring thermodilution right ventricular ejection fractions.
Critical care medicine 1991;19(3):417-21.
1991: M Tomita; Francis G Spinale; Fred A Crawford; Michael R Zile
Changes in left ventricular volume, mass, and function during the development and regression of supraventricular tachycardia-induced cardiomyopathy. Disparity between recovery of systolic versus diastolic function.
Circulation 1991;83(2):635-44.
1991: Francis G Spinale; A P Pearce; Bradley A Schulte; Fred A Crawford
Ventricular function and Na+,K(+)-ATPase activity and distribution with chronic supraventricular tachycardia.
Cardiovascular research 1991;25(2):138-44.
1991: Rupak Mukherjee; Francis G Spinale; A F von Recum; Fred A Crawford
In vitro validation of a right ventricular thermodilution ejection fraction system.
Annals of biomedical engineering 1991;19(2):165-77.
1991: James L Zellner; Francis G Spinale; Fred A Crawford; James A Cook
Right ventricular pump dysfunction with acute experimental septic shock.
The Journal of surgical research 1991;50(1):93-9.
1991: M Michael Swindle; Francis G Spinale; Alison C Smith; R E Schumann; C T Green; K Nakano; S Kanasawa; K Ishihara; Michael R Zile; Blase A Carabello
Anesthetic and postoperative protocols for a canine model of reversible left ventricular volume overload.
Journal of investigative surgery : the official journal of the Academy of Surgical Research 1991;4(3):339-46.
1991: B I Tarnowski; Francis G Spinale; J H Nicholson
DAPI as a useful stain for nuclear quantitation.
Biotechnic & histochemistry : official publication of the Biological Stain Commission 1991;66(6):297-302.
1990: Francis G Spinale; James L Zellner; Rupak Mukherjee; S E Ferris; Fred A Crawford
Thermodilution right ventricular ejection fraction. Catheter positioning effects.
Chest 1990;98(5):1259-65.
1990: D C Winston; Francis G Spinale; Fred A Crawford; Bradley A Schulte
Immunocytochemical and enzyme histochemical localization of Na+,K(+)-ATPase in normal and ischemic porcine myocardium.
Journal of molecular and cellular cardiology 1990;22(10):1071-82.
1990: D A Hendrick; Alison C Smith; John M Kratz; Fred A Crawford; Francis G Spinale
The pig as a model of tachycardia and dilated cardiomyopathy.
Laboratory animal science 1990;40(5):495-501.
1990: Francis G Spinale; D A Hendrick; Fred A Crawford; Alison C Smith; Y Hamada; Blase A Carabello
Chronic supraventricular tachycardia causes ventricular dysfunction and subendocardial injury in swine.
The American journal of physiology 1990;259(1 Pt 2):H218-29.
1990: Francis G Spinale; D A Hendrick; Fred A Crawford; Blase A Carabello
Relationship between bioimpedance, thermodilution, and ventriculographic measurements in experimental congestive heart failure.
Cardiovascular research 1990;24(5):423-9.
1990: James L Zellner; Francis G Spinale; Fred A Crawford
Bioimpedance: a novel method for the determination of extravascular lung water.
The Journal of surgical research 1990;48(5):454-9.
1990: Francis G Spinale; B A Carabello; Fred A Crawford
Right ventricular function and three-dimensional modeling using computer-aided design.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;68(4):1707-16.
1990: Francis G Spinale; Alison C Smith; Fred A Crawford
Relationship of bioimpedance to thermodilution and echocardiographic measurements of cardiac function.
Critical care medicine 1990;18(4):414-8.
1990: M Michael Swindle; Robert P Thompson; Blase A Carabello; Alison C Smith; B J Hepburn; D R Bodison; W Corin; A Fazel; W W Biederman; Francis G Spinale
Heritable ventricular septal defect in Yucatan miniature swine.
Laboratory animal science 1990;40(2):155-61.
1990: Francis G Spinale; Blase A Carabello; Bradley A Schulte; Fred A Crawford
Wavefront myocyte injury and relationship to function in right ventricular ischemia.
The American journal of physiology 1990;258(2 Pt 2):H292-304.
1990: Francis G Spinale; Alison C Smith; Blase A Carabello; Fred A Crawford
Right ventricular function computed by thermodilution and ventriculography. A comparison of methods.
The Journal of thoracic and cardiovascular surgery 1990;99(1):141-52.
1990: Alison C Smith; Francis G Spinale; M Michael Swindle
Cardiac function and morphology of Hanford miniature swine and Yucatan miniature and micro swine.
Laboratory animal science 1990;40(1):47-50.
1989: Francis G Spinale; H D Reines; M C Cook; Fred A Crawford
Noninvasive estimation of extravascular lung water using bioimpedance.
The Journal of surgical research 1989;47(6):535-40.
1989: Robert B Leman; Francis G Spinale; G W Dorn; George Cooper; J F Spann; PC Gillette; Blase A Carabello
Supernormal ejection performance is isolated to the ipsilateral congenitally pressure-overloaded ventricle.
Journal of the American College of Cardiology 1989;13(6):1314-9.
1989: Francis G Spinale; Bradley A Schulte; Fred A Crawford
Demonstration of early ischemic injury in porcine right ventricular myocardium.
The American journal of pathology 1989;134(3):693-704.
1989: Francis G Spinale; R W Linker; Fred A Crawford; H D Reines
Conventional versus high frequency jet ventilation with a bronchopleural fistula.
The Journal of surgical research 1989;46(2):147-51.
1989: Alison C Smith; Francis G Spinale; Blase A Carabello; M Michael Swindle
Technical aspects of cardiac catheterization of swine.
Journal of investigative surgery : the official journal of the Academy of Surgical Research 1989;2(2):187-94.
1988: F W Clevenger; R W Linker; Fred A Crawford; Francis G Spinale; H D Reines
The use of positive end expiratory pressure to alter systemic-pulmonary shunt flow using conventional and high frequency jet ventilators.
Current surgery 1988;45(3):212-4.
1988: Francis G Spinale; H D Reines; Fred A Crawford
Comparison of bioimpedance and thermodilution methods for determining cardiac output: experimental and clinical studies.
The Annals of thoracic surgery 1988;45(4):421-5.
1987: R L Ullom; Robert M Sade; Fred A Crawford; B A Ross; Francis G Spinale
The Blalock-Taussig shunt in infants: standard versus modified.
The Annals of thoracic surgery 1987;44(5):539-43.
1986: Fred A Crawford; Robert M Sade; Francis G Spinale
Bovine pericardium for correction of congenital heart defects.
The Annals of thoracic surgery 1986;41(6):602-5.