FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Stephen Spindler

Research Profile

Living Beings

Concepts & Ideas

Physiology

Chemicals & Drugs

Co-author Network

Publications

TOP 3
Stephen R Spindler; James M Flegal; Patricia L Mote; Bruce Teter
Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to long-lived, F1 hybrid mice.
Joseph M Dhahbi; Noel Guerrero; Hani Atamna; Dario Boffelli; Patricia L Mote; Stephen R Spindler; Amy Yamakawa; David I K Martin
Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction.
Joseph M Dhahbi; Hani Atamna; Dario Boffelli; Patricia L Mote; Stephen R Spindler; Amy Yamakawa; David I K Martin
5' tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Stephen Spindler (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Stephen R Spindler; James M Flegal; Patricia L Mote; Bruce Teter
Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, pycnogenol, quercetin, and taxifolin fed iso-calorically to long-lived, F1 hybrid mice.
Rejuvenation research 2013;16(2):143-51.
2013: Joseph M Dhahbi; Noel Guerrero; Hani Atamna; Dario Boffelli; Patricia L Mote; Stephen R Spindler; Amy Yamakawa; David I K Martin
Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction.
Aging 2013;5(2):130-41.
2013: Joseph M Dhahbi; Hani Atamna; Dario Boffelli; Patricia L Mote; Stephen R Spindler; Amy Yamakawa; David I K Martin
5' tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction.
BMC genomics 2013;14():298.
2012: Joseph M Dhahbi; David I K Martin; Hani Atamna; Dario Boffelli; Stephen R Spindler
mRNA-Seq reveals complex patterns of gene regulation and expression in the mouse skeletal muscle transcriptome associated with calorie restriction.
Physiological genomics 2012;44(6):331-44.
2012: Stephen R Spindler; Yinsheng Wang; Renee T Williams; Amy Yamakawa; Rolf Bodmer; Joseph M Dhahbi; Rui Li; Patricia L Mote; Karen Ocorr; Kenneth P Ablao
Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.
PloS one 2012;7(6):e39581.
2012: Stephen R Spindler; Amy Yamakawa; Joseph M Dhahbi; Rui Li; Frank Sauer
Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila.
PloS one 2012;7(2):e29782.
2011: Wayne Pereanu; Amelia Younossi-Hartenstein; Jennifer Lovick; Stephen R Spindler; Volker Hartenstein
Lineage-based analysis of the development of the central complex of the Drosophila brain.
The Journal of comparative neurology 2011;519(4):661-89.
2011: Joseph M Dhahbi; Hani Atamna; Dario Boffelli; Wendy Magis; Stephen R Spindler; David I K Martin
Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence.
PloS one 2011;6(5):e20509.
2011: Stephen R Spindler; Volker Hartenstein
Bazooka mediates secondary axon morphology in Drosophila brain lineages.
Neural development 2011;6():16.
2010: Stephen R Spindler
Caloric restriction: from soup to nuts.
Ageing research reviews 2010;9(3):324-53.
2009: Camilla Larsen; Diana Shy; Stephen R Spindler; Siaumin Fung; Wayne Pereanu; Amelia Younossi-Hartenstein; Volker Hartenstein
Patterns of growth, axonal extension and axonal arborization of neuronal lineages in the developing Drosophila brain.
Developmental biology 2009;335(2):289-304.
2009: Stephen R Spindler; Irma Ortiz; Siaumin Fung; Shigeo Takashima; Volker Hartenstein
Drosophila cortex and neuropile glia influence secondary axon tract growth, pathfinding, and fasciculation in the developing larval brain.
Developmental biology 2009;334(2):355-68.
2007: Stephen R Spindler; Patricia L Mote
Screening candidate longevity therapeutics using gene-expression arrays.
Gerontology 2007;53(5):306-21.
2007: Stephen R Spindler; Joseph M Dhahbi
Conserved and tissue-specific genic and physiologic responses to caloric restriction and altered IGFI signaling in mitotic and postmitotic tissues.
Annual review of nutrition 2007;27():193-217.
2006: Joseph M Dhahbi; Tomoshi Tsuchiya; Hyon Jeen Kim; Patricia L Mote; Stephen R Spindler
Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(3):218-31.
2006: Stephen R Spindler
Use of microarray biomarkers to identify longevity therapeutics.
Aging cell 2006;5(1):39-50.
2005: Joseph M Dhahbi; Patricia L Mote; Gregory M Fahy; Stephen R Spindler
Identification of potential caloric restriction mimetics by microarray profiling.
Physiological genomics 2005;23(3):343-50.
2005: Stephen R Spindler
Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction.
Mechanisms of ageing and development 2005;126(9):960-6.
2004: Tomoshi Tsuchiya; Joseph M Dhahbi; Xinping Cui; Patricia L Mote; Andrzej Bartke; Stephen R Spindler
Additive regulation of hepatic gene expression by dwarfism and caloric restriction.
Physiological genomics 2004;17(3):307-15.
2004: Joseph M Dhahbi; Hyon Jeen Kim; Patricia L Mote; Robert J Beaver; Stephen R Spindler
Temporal linkage between the phenotypic and genomic responses to caloric restriction.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5524-9.
2003: Joseph M Dhahbi; Patricia L Mote; Shelley X Cao; Stephen R Spindler
Hepatic gene expression profiling of streptozotocin-induced diabetes.
Diabetes technology & therapeutics 2003;5(3):411-20.
2002: Joseph M Dhahbi; Shelley X Cao; Patricia L Mote; Brian C Rowley; John E Wingo; Stephen R Spindler
Postprandial induction of chaperone gene expression is rapid in mice.
The Journal of nutrition 2002;132(1):31-7.
2001: Stephen R Spindler
Reversing the negative genomic effects of aging with short-term calorie restriction.
TheScientificWorldJournal 2001;1():544-6.
2001: Shelley X Cao; Joseph M Dhahbi; Patricia L Mote; Stephen R Spindler
Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(19):10630-5.
2001: Joseph M Dhahbi; Patricia L Mote; John E Wingo; B C Rowley; Shelley X Cao; Roy L Walford; Stephen R Spindler
Caloric restriction alters the feeding response of key metabolic enzyme genes.
Mechanisms of ageing and development 2001;122(10):1033-48.
2001: Joseph M Dhahbi; Shelley X Cao; JB Tillman; Patricia L Mote; M Madore; Roy L Walford; Stephen R Spindler
Chaperone-mediated regulation of hepatic protein secretion by caloric restriction.
Biochemical and biophysical research communications 2001;284(2):335-9.
2001: Stephen R Spindler
Calorie restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging.
Annals of the New York Academy of Sciences 2001;928():296-304.
1999: Paul D Thompson; Jui-Cheng Hsieh; G Kerr Whitfield; Carol A Haussler; Peter Jurutka; Michael A Galligan; JB Tillman; Stephen R Spindler; Mark R Haussler
Vitamin D receptor displays DNA binding and transactivation as a heterodimer with the retinoid X receptor, but not with the thyroid hormone receptor.
Journal of cellular biochemistry 1999;75(3):462-80.
1999: Joseph M Dhahbi; Patricia L Mote; John E Wingo; JB Tillman; Roy L Walford; Stephen R Spindler
Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes.
The American journal of physiology 1999;277(2 Pt 1):E352-60.
1998: Patricia L Mote; JB Tillman; Stephen R Spindler
Glucose regulation of GRP78 gene expression.
Mechanisms of ageing and development 1998;104(2):149-58.
1998: Joseph M Dhahbi; JB Tillman; S Cao; Patricia L Mote; Roy L Walford; Stephen R Spindler
Caloric intake alters the efficiency of catalase mRNA translation in the liver of old female mice.
The journals of gerontology. Series A, Biological sciences and medical sciences 1998;53(3):B180-5.
1997: Joseph M Dhahbi; Patricia L Mote; JB Tillman; Roy L Walford; Stephen R Spindler
Dietary energy tissue-specifically regulates endoplasmic reticulum chaperone gene expression in the liver of mice.
The Journal of nutrition 1997;127(9):1758-64.
1997: Roy L Walford; Stephen R Spindler
The response to calorie restriction in mammals shows features also common to hibernation: a cross-adaptation hypothesis.
The journals of gerontology. Series A, Biological sciences and medical sciences 1997;52(4):B179-83.
1996: JB Tillman; Joseph M Dhahbi; Patricia L Mote; Roy L Walford; Stephen R Spindler
Dietary calorie restriction in mice induces carbamyl phosphate synthetase I gene transcription tissue specifically.
The Journal of biological chemistry 1996;271(7):3500-6.
1996: JB Tillman; Patricia L Mote; Joseph M Dhahbi; Roy L Walford; Stephen R Spindler
Dietary energy restriction in mice negatively regulates hepatic glucose-regulated protein 78 (GRP78) expression at the posttranscriptional level.
The Journal of nutrition 1996;126(2):416-23.
1995: JB Tillman; Patricia L Mote; Roy L Walford; Stephen R Spindler
Structure and regulation of the mouse GRP78 (BiP) promoter by glucose and calcium ionophore.
Gene 1995;158(2):225-9.
1994: Walker Force; Stephen R Spindler
3,5,3'-L-triiodothyronine (thyroid hormone)-induced protein-DNA interactions in the thyroid hormone response elements and cell type-specific elements of the rat growth hormone gene revealed by in vivo dimethyl sulfate footprinting.
The Journal of biological chemistry 1994;269(13):9682-6.
1994: Walker Force; JB Tillman; Carl Sprung; Stephen R Spindler
Homodimer and heterodimer DNA binding and transcriptional responsiveness to triiodothyronine (T3) and 9-cis-retinoic acid are determined by the number and order of high affinity half-sites in a T3 response element.
The Journal of biological chemistry 1994;269(12):8863-71.
1993: JB Tillman; D E Crone; H S Kim; Carl Sprung; Stephen R Spindler
Promoter independent down-regulation of the firefly luciferase gene by T3 and T3 receptor in CV1 cells.
Molecular and cellular endocrinology 1993;95(1-2):101-9.
1992: H S Kim; D E Crone; Carl Sprung; JB Tillman; Walker Force; M D Crew; Patricia L Mote; Stephen R Spindler
Positive and negative thyroid hormone response elements are composed of strong and weak half-sites 10 nucleotides in length.
Molecular endocrinology (Baltimore, Md.) 1992;6(9):1489-501.
1991: Stephen R Spindler; J M Grizzle; Roy L Walford; Patricia L Mote
Aging and restriction of dietary calories increases insulin receptor mRNA, and aging increases glucocorticoid receptor mRNA in the liver of female C3B10RF1 mice.
Journal of gerontology 1991;46(6):B233-7.
1991: Patricia L Mote; J M Grizzle; Roy L Walford; Stephen R Spindler
Influence of age and caloric restriction on expression of hepatic genes for xenobiotic and oxygen metabolizing enzymes in the mouse.
Journal of gerontology 1991;46(3):B95-100.
1991: Patricia L Mote; J M Grizzle; Roy L Walford; Stephen R Spindler
Aging alters hepatic expression of insulin receptor and c-jun mRNA in the mouse.
Mutation research 1991;256(1):7-12.
1990: Stephen R Spindler; M D Crew; Patricia L Mote; J M Grizzle; Roy L Walford
Dietary energy restriction in mice reduces hepatic expression of glucose-regulated protein 78 (BiP) and 94 mRNA.
The Journal of nutrition 1990;120(11):1412-7.
1990: D E Crone; H S Kim; Stephen R Spindler
Alpha and beta thyroid hormone receptors bind immediately adjacent to the rat growth hormone gene TATA box in a negatively hormone-responsive promoter region.
The Journal of biological chemistry 1990;265(19):10851-6.
1990: Patricia L Mote; J M Grizzle; Roy L Walford; Stephen R Spindler
Age-related down regulation of hepatic cytochrome P1-450, P3-450, catalase and CuZn-superoxide dismutase RNA.
Mechanisms of ageing and development 1990;53(1):101-10.
1989: Stephen R Spindler; A Koizumi; Roy L Walford; Patricia L Mote
P1-450 and P3-450 gene expression and maximum life span in mice.
Mutation research 1989;219(2):89-94.
1989: Stephen R Spindler; M D Crew; J K Nyborg
Thyroid hormone transcriptional regulatory region of the growth hormone gene.
Endocrine research 1989;15(4):475-93.
1988: Patricia Wight; M D Crew; Stephen R Spindler
Sequences essential for activity of the thyroid hormone responsive transcription stimulatory element of the rat growth hormone gene.
Molecular endocrinology (Baltimore, Md.) 1988;2(6):536-42.
1987: M D Crew; Stephen R Spindler; Roy L Walford; A Koizumi
Age-related decrease of growth hormone and prolactin gene expression in the mouse pituitary.
Endocrinology 1987;121(4):1251-5.
1987: Patricia Wight; M D Crew; Stephen R Spindler
Discrete positive and negative thyroid hormone-responsive transcription regulatory elements of the rat growth hormone gene.
The Journal of biological chemistry 1987;262(12):5659-63.
1986: J K Nyborg; Stephen R Spindler
Alterations in local chromatin structure accompany thyroid hormone induction of growth hormone gene transcription.
The Journal of biological chemistry 1986;261(13):5685-8.
1986: M D Crew; Stephen R Spindler
Thyroid hormone regulation of the transfected rat growth hormone promoter.
The Journal of biological chemistry 1986;261(11):5018-22.
1985: J K Nyborg; A P Nguyen; Stephen R Spindler
Cyclic regulation of growth hormone gene transcription in vivo and in vitro.
Endocrinology 1985;116(6):2361-5.
1985: R L Williams; Duilio Cascio; Patricia Wight; Stephen R Spindler
A computer method for scanning and analysis of dot blots.
DNA (Mary Ann Liebert, Inc.) 1985;4(3):255-62.
1984: J K Nyborg; A P Nguyen; Stephen R Spindler
Relationship between thyroid and glucocorticoid hormone receptor occupancy, growth hormone gene transcription, and mRNA accumulation.
The Journal of biological chemistry 1984;259(20):12377-81.