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Brian Spratt

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Lyndsey O Hudson; Diane Kim; Lydia Mikhail; Douglas F Moore; Courtney R Murphy; Christopher Nguyen; Brian G Spratt; Leah Terpstra; Richard Alexander; Kristen Elkins; Mark C Enright; Adrijana Gombosev; Paul Hannah; Susan S Huang
Diversity of Methicillin-Resistant Staphylococcus aureus (MRSA) Strains Isolated from Inpatients of 30 Hospitals in Orange County, California.
Brian G Spratt
The 2011 Garrod Lecture: From penicillin-binding proteins to molecular epidemiology.
Simon R Harris; Martin J Holland; David A Lewis; David Mabey; Peter Marsh; Servaas A Morré; Julian Parkhill; Rosanna W Peeling; Kenneth Persson; Helena M B Seth-Smith; Rachel J Skilton; Anthony W Solomon; Arjen G C L Speksnijder; Brian G Spratt; Cécile M Bébéar; Carina Bjartling; Robert brunham; Ian N Clarke; Maïté Clerc; Lesley T Cutcliffe; Bertille De Barbeyrac; Henry J C de Vries; Magnus Unemo; Nicholas R Thomson
Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing.

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All Publications

2013: Lyndsey O Hudson; Diane Kim; Lydia Mikhail; Douglas F Moore; Courtney R Murphy; Christopher Nguyen; Brian G Spratt; Leah Terpstra; Richard Alexander; Kristen Elkins; Mark C Enright; Adrijana Gombosev; Paul Hannah; Susan S Huang
Diversity of Methicillin-Resistant Staphylococcus aureus (MRSA) Strains Isolated from Inpatients of 30 Hospitals in Orange County, California.
PloS one 2013;8(4):e62117.
2012: Brian G Spratt
The 2011 Garrod Lecture: From penicillin-binding proteins to molecular epidemiology.
The Journal of antimicrobial chemotherapy 2012;67(7):1578-88.
2012: Simon R Harris; Martin J Holland; David A Lewis; David Mabey; Peter Marsh; Servaas A Morré; Julian Parkhill; Rosanna W Peeling; Kenneth Persson; Helena M B Seth-Smith; Rachel J Skilton; Anthony W Solomon; Arjen G C L Speksnijder; Brian G Spratt; Cécile M Bébéar; Carina Bjartling; Robert brunham; Ian N Clarke; Maïté Clerc; Lesley T Cutcliffe; Bertille De Barbeyrac; Henry J C de Vries; Magnus Unemo; Nicholas R Thomson
Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing.
Nature genetics 2012;44(4):413-9, S1.
2012: Claire E Turner; Deborah L W Chong; Frances J Davies; Androulla Efstratiou; Leili Farzaneh; Matthew T G Holden; Karen McGregor; Bruno Pichon; Mary Sommerlad; Brian G Spratt; Shiranee Sriskandan
Superantigenic activity of emm3 Streptococcus pyogenes is abrogated by a conserved, naturally occurring smeZ mutation.
PloS one 2012;7(10):e46376.
2011: Vanya Hampton; Glenda Harrington; Mirjam Kaestli; Mark Mayo; Richard Noske; Leisha Richardson; Brian G Spratt; Suresh Benedict; Jodie Low Choy; Stephen T Garnett; Daniel Godoy; Bart J Currie
Melioidosis in Birds and Burkholderia pseudomallei Dispersal, Australia.
Emerging infectious diseases 2011;17(7):1310-2.
2011: Mark Mayo; Brian G Spratt; Linda Ward; Allen C Cheng; Daniel Godoy; Glenda Harrington; Peter Jolly; Mirjam Kaesti; Danuta Karp; Bart J Currie
Burkholderia pseudomallei in unchlorinated domestic bore water, Tropical Northern Australia.
Emerging infectious diseases 2011;17(7):1283-5.
2011: Chiranjay Mukhopadhyay; Leisha Richardson; Brian G Spratt; Krishna Sushma; Apichai Tuanyok; Kalwaje Eshwara Vandana; Daniel Godoy; Mirjam Kaestli; Paul Keim; Mark Mayo; Bart J Currie
Molecular characterization of clinical Burkholderia pseudomallei isolates from India.
The American journal of tropical medicine and hygiene 2011;85(1):121-3.
2011: Angeliki Mavroidi; Eva Tzelepi; Eirini Siatravani; Daniel Godoy; Vivi Miriagou; Brian G Spratt
Analysis of emergence of quinolone-resistant gonococci in Greece by combined use of Neisseria gonorrhoeae multiantigen sequence typing and multilocus sequence typing.
Journal of clinical microbiology 2011;49(4):1196-201.
2010: Josilene B T Lima; Guilherme S Ribeiro; Soraia M Cordeiro; Edilane L Gouveia; Kátia Salgado; Brian G Spratt; Daniel Godoy; Mitermayer G Reis; Albert I Ko; Joice N Reis
Poor clinical outcome for meningitis caused by Haemophilus influenzae serotype A strains containing the IS1016-bexA deletion.
The Journal of infectious diseases 2010;202(10):1577-84.
2009: Matthew T G Holden; Zoe Heather; Romain Paillot; Karen F Steward; Katy Webb; Fern Ainslie; Thibaud Jourdan; Nathalie C Bason; Nancy E Holroyd; Karen Mungall; Michael A Quail; Mandy Sanders; Mark Simmonds; David Willey; Karen Brooks; David M Aanensen; Brian G Spratt; Keith Jolley; Martin C J Maiden; Michael Kehoe; Neil Chanter; Stephen D Bentley; Carl Robinson; Duncan J Maskell; Julian Parkhill; Andrew S Waller
Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens.
PLoS pathogens 2009;5(3):e1000346.
2009: Nicole Bilek; Catherine A Ison; Brian G Spratt
Relative contributions of recombination and mutation to the diversification of the opa gene repertoire of Neisseria gonorrhoeae.
Journal of bacteriology 2009;191(6):1878-90.
2009: Christophe Fraser; Eric J Alm; Martin F Polz; Brian G Spratt; William P Hanage
The bacterial species challenge: making sense of genetic and ecological diversity.
Science (New York, N.Y.) 2009;323(5915):741-6.
2009: David M Aanensen; Derek M Huntley; Edward J Feil; Fada'a al-Own; Brian G Spratt
EpiCollect: linking smartphones to web applications for epidemiology, ecology and community data collection.
PloS one 2009;4(9):e6968.
2009: Cynthia J Bishop; David M Aanensen; Gregory E Jordan; Mogens Kilian; William P Hanage; Brian G Spratt
Assigning strains to bacterial species via the internet.
BMC biology 2009;7():3.
2008: Allen C Cheng; Linda Ward; Daniel Godoy; Robert Norton; Mark Mayo; Daniel Gal; Brian G Spratt; Bart J Currie
Genetic diversity of Burkholderia pseudomallei isolates in Australia.
Journal of clinical microbiology 2008;46(1):249-54.
2007: Bart J Currie; Annette D Thomas; Daniel Godoy; David A Dance; Allen C Cheng; Linda Ward; Mark Mayo; Tyrone L Pitt; Brian G Spratt
Australian and Thai isolates of Burkholderia pseudomallei are distinct by multilocus sequence typing: revision of a case of mistaken identity.
Journal of clinical microbiology 2007;45(11):3828-9.
2007: Nicole Bilek; Iona M C Martin; Gill Bell; George R Kinghorn; Catherine A Ison; Brian G Spratt
Concordance between Neisseria gonorrhoeae genotypes recovered from known sexual contacts.
Journal of clinical microbiology 2007;45(11):3564-7.
2007: Angeliki Mavroidi; David M Aanensen; Daniel Godoy; Ian C Skovsted; Margit S Kaltoft; peter reeves; Stephen Bentley; Brian G Spratt
Genetic relatedness of the Streptococcus pneumoniae capsular biosynthetic loci.
Journal of bacteriology 2007;189(21):7841-55.
2007: David M Aanensen; Angeliki Mavroidi; Stephen Bentley; peter reeves; Brian G Spratt
Predicted functions and linkage specificities of the products of the Streptococcus pneumoniae capsular biosynthetic loci.
Journal of bacteriology 2007;189(21):7856-76.
2007: E J Bishop; C Shilton; S Benedict; F Kong; G L Gilbert; Daniel Gal; Daniel Godoy; Brian G Spratt; Bart J Currie
Necrotizing fasciitis in captive juvenile Crocodylus porosus caused by Streptococcus agalactiae: an outbreak and review of the animal and human literature.
Epidemiology and infection 2007;135(8):1248-55.
2007: Claire L Risley; Helen Ward; Bhudipa Choudhury; Cynthia J Bishop; Kevin A Fenton; Brian G Spratt; Catherine A Ison; Azra C Ghani
Geographical and demographic clustering of gonorrhoea in London.
Sexually transmitted infections 2007;83(6):481-7.
2007: Christophe Fraser; William P Hanage; Brian G Spratt
Recombination and the nature of bacterial speciation.
Science (New York, N.Y.) 2007;315(5811):476-80.
2007: Bart J Currie; Daniel Gal; Mark Mayo; Linda Ward; Daniel Godoy; Brian G Spratt; John J LiPuma
Using BOX-PCR to exclude a clonal outbreak of melioidosis.
BMC infectious diseases 2007;7():68.
2007: Katy Turner; William P Hanage; Christophe Fraser; Thomas R Connor; Brian G Spratt
Assessing the reliability of eBURST using simulated populations with known ancestry.
BMC microbiology 2007;7():30.
2006: Mindy Glass; Jay E Gee; Arnold G Steigerwalt; Dominick Cavuoti; Theresa Barton; R Doug Hardy; Daniel Godoy; Brian G Spratt; Thomas A Clark; Patricia P Wilkins
Pneumonia and septicemia caused by Burkholderia thailandensis in the United States.
Journal of clinical microbiology 2006;44(12):4601-4.
2006: William P Hanage; Brian G Spratt; Katy Turner; Christophe Fraser
Modelling bacterial speciation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1475):2039-44.
2006: William P Hanage; Christophe Fraser; Brian G Spratt
Sequences, sequence clusters and bacterial species.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1475):1917-27.
2006: Bhudipa Choudhury; Claire L Risley; Azra C Ghani; Cynthia J Bishop; Helen Ward; Kevin A Fenton; Catherine A Ison; Brian G Spratt
Identification of individuals with gonorrhoea within sexual networks: a population-based study.
Lancet 2006;368(9530):139-46.
2006: Nicola Jones; Karen A Oliver; Joanne Barry; Rosalind M Harding; Naiel Bisharat; Brian G Spratt; T E A Peto; Derrick W Crook
Enhanced invasiveness of bovine-derived neonatal sequence type 17 group B streptococcus is independent of capsular serotype.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(7):915-24.
2006: William P Hanage; Christophe Fraser; Brian G Spratt
The impact of homologous recombination on the generation of diversity in bacteria.
Journal of theoretical biology 2006;239(2):210-9.
2006: Stephen Bentley; David M Aanensen; Angeliki Mavroidi; David Saunders; Ester Rabbinowitsch; Matthew Collins; Kathy Donohoe; David Harris; Lee Murphy; Michael A Quail; Gabrielle N Samuel; Ian C Skovsted; Margit S Kaltoft; Bart Barrell; peter reeves; Julian Parkhill; Brian G Spratt
Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes.
PLoS genetics 2006;2(3):e31.
2006: William P Hanage; Tarja Kaijalainen; Annika Saukkoriipi; J L Rickcord; Brian G Spratt
A successful, diverse disease-associated lineage of nontypeable pneumococci that has lost the capsular biosynthesis locus.
Journal of clinical microbiology 2006;44(3):743-9.
2005: Simon Le Hello; Bart J Currie; Daniel Godoy; Brian G Spratt; Marc Mikulski; Flore Lacassin; Benoit Garin
Melioidosis in New Caledonia.
Emerging infectious diseases 2005;11(10):1607-9.
2005: HM Palmer; Hugh Young; Iona M C Martin; Catherine A Ison; Brian G Spratt
The epidemiology of ciprofloxacin resistant isolates of Neisseria gonorrhoeae in Scotland 2002: a comparison of phenotypic and genotypic analysis.
Sexually transmitted infections 2005;81(5):403-7.
2005: Iona M C Martin; Catherine A Ison; David M Aanensen; Kevin A Fenton; Brian G Spratt
Changing epidemiologic profile of quinolone-resistant Neisseria gonorrhoeae in London.
The Journal of infectious diseases 2005;192(7):1191-5.
2005: J C Abbott; David M Aanensen; Kim Rutherford; S Butcher; Brian G Spratt
WebACT--an online companion for the Artemis Comparison Tool.
Bioinformatics (Oxford, England) 2005;21(18):3665-6.
2005: William P Hanage; Tarja Kaijalainen; Elja Herva; Annika Saukkoriipi; Ritva Syrjänen; Brian G Spratt
Using multilocus sequence data to define the pneumococcus.
Journal of bacteriology 2005;187(17):6223-30.
2005: David M Aanensen; Brian G Spratt
The multilocus sequence typing network: mlst.net.
Nucleic acids research 2005;33(Web Server issue):W728-33.
2005: Karen F McGregor; Brian G Spratt
Identity and prevalence of multilocus sequence typing-defined clones of group A streptococci within a hospital setting.
Journal of clinical microbiology 2005;43(4):1963-7.
2005: Christophe Fraser; William P Hanage; Brian G Spratt
Neutral microepidemic evolution of bacterial pathogens.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1968-73.
2005: William P Hanage; Christophe Fraser; Brian G Spratt
Fuzzy species among recombinogenic bacteria.
BMC biology 2005;3():6.
2005: William P Hanage; Tarja Kaijalainen; Ritva Syrjänen; Kari Auranen; Maija Leinonen; P Helena Mäkelä; Brian G Spratt
Invasiveness of serotypes and clones of Streptococcus pneumoniae among children in Finland.
Infection and immunity 2005;73(1):431-5.
2004: Brian G Spratt; William P Hanage; Bao Li; David M Aanensen; Edward J Feil
Displaying the relatedness among isolates of bacterial species -- the eBURST approach.
FEMS microbiology letters 2004;241(2):129-34.
2004: Nurith Porat; Adriano Arguedas; Brian G Spratt; Ronit Trefler; Eduardo Brilla; Cecilia Loaiza; Daniel Godoy; Nicole Bilek; Ron Dagan
Emergence of penicillin-nonsusceptible Streptococcus pneumoniae clones expressing serotypes not present in the antipneumococcal conjugate vaccine.
The Journal of infectious diseases 2004;190(12):2154-61.
2004: Allen C Cheng; Daniel Godoy; Mark Mayo; Daniel Gal; Brian G Spratt; Bart J Currie
Isolates of Burkholderia pseudomallei from Northern Australia are distinct by multilocus sequence typing, but strain types do not correlate with clinical presentation.
Journal of clinical microbiology 2004;42(12):5477-83.
2004: Angeliki Mavroidi; Daniel Godoy; David M Aanensen; D Ashley Robinson; Susan Kay Hollingshead; Brian G Spratt
Evolutionary genetics of the capsular locus of serogroup 6 pneumococci.
Journal of bacteriology 2004;186(24):8181-92.
2004: Brian G Spratt
John Maynard Smith (1920-2004).
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2004;4(4):297-300.
2004: Angela B Brueggemann; T E A Peto; Derrick W Crook; Jay C Butler; Karl G Kristinsson; Brian G Spratt
Temporal and geographic stability of the serogroup-specific invasive disease potential of Streptococcus pneumoniae in children.
The Journal of infectious diseases 2004;190(7):1203-11.
2004: Marie-Elisabeth BOUGNOUX; David M Aanensen; Serge Morand; Magali Théraud; Brian G Spratt; Christophe d'Enfert
Multilocus sequence typing of Candida albicans: strategies, data exchange and applications.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2004;4(3):243-52.
2004: Karen F McGregor; Brian G Spratt; Awdhesh Kalia; Alicia Bennett; Nicole Bilek; Bernard W. Beall; Debra E Bessen
Multilocus sequence typing of Streptococcus pyogenes representing most known emm types and distinctions among subpopulation genetic structures.
Journal of bacteriology 2004;186(13):4285-94.
2004: Iona M C Martin; Catherine A Ison; David M Aanensen; Kevin A Fenton; Brian G Spratt
Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area.
The Journal of infectious diseases 2004;189(8):1497-505.
2004: Edward J Feil; Bao C Li; David M Aanensen; William P Hanage; Brian G Spratt
eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data.
Journal of bacteriology 2004;186(5):1518-30.
2004: Karen F McGregor; Nicole Bilek; Alicia Bennett; Awdhesh Kalia; Bernard W. Beall; Jonathan R Carapetis; Bart J Currie; Kadaba S Sriprakash; Brian G Spratt; Debra E Bessen
Group A streptococci from a remote community have novel multilocus genotypes but share emm types and housekeeping alleles with isolates from worldwide sources.
The Journal of infectious diseases 2004;189(4):717-23.
2004: Brian G Spratt
Exploring the concept of clonality in bacteria.
Methods in molecular biology (Clifton, N.J.) 2004;266():323-52.
2004: William P Hanage; Kari Auranen; Ritva Syrjänen; Elja Herva; P Helena Mäkelä; Terhi Kilpi; Brian G Spratt
Ability of pneumococcal serotypes and clones to cause acute otitis media: implications for the prevention of otitis media by conjugate vaccines.
Infection and immunity 2004;72(1):76-81.
2003: Angela B Brueggemann; Brian G Spratt
Geographic distribution and clonal diversity of Streptococcus pneumoniae serotype 1 isolates.
Journal of clinical microbiology 2003;41(11):4966-70.
2003: Nicola Jones; John F Bohnsack; Shinji Takahashi; Karen A Oliver; Man-Suen Chan; Frank Kunst; Philippe Glaser; Christophe Rusniok; Derrick W Crook; Rosalind M Harding; Naiel Bisharat; Brian G Spratt
Multilocus sequence typing system for group B streptococcus.
Journal of clinical microbiology 2003;41(6):2530-6.
2003: Edward J Feil; Jessica E Cooper; Hajo Grundmann; D Ashley Robinson; Mark Enright; Tony Berendt; Sharon J Peacock; John Maynard Smith; Michael Murphy; Brian G Spratt; Catrin E Moore; Nicholas P J Day
How clonal is Staphylococcus aureus?
Journal of bacteriology 2003;185(11):3307-16.
2003: Daniel Godoy; Gaynor Randle; Andrew J Simpson; David M Aanensen; Tyrone L Pitt; Reimi Kinoshita; Brian G Spratt
Multilocus sequence typing and evolutionary relationships among the causative agents of melioidosis and glanders, Burkholderia pseudomallei and Burkholderia mallei.
Journal of clinical microbiology 2003;41(5):2068-79.
2003: Angela B Brueggemann; David T Griffiths; Emma Meats; T E A Peto; Derrick W Crook; Brian G Spratt
Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential.
The Journal of infectious diseases 2003;187(9):1424-32.
2003: Emma Meats; Edward J Feil; Suzanna Stringer; Alison J Cody; Richard Goldstein; J Simon Kroll; Tanja Popovic; Brian G Spratt
Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing.
Journal of clinical microbiology 2003;41(4):1623-36.
2003: Brian G Spratt
Microbiology. Stomachs out of Africa.
Science (New York, N.Y.) 2003;299(5612):1528-9.
2003: Ewa Sadowy; Jiaji Zhou; Emma Meats; Marek Gniadkowski; Brian G Spratt; Waleria Hryniewicz
Identification of multidrug-resistant Streptococcus pneumoniae strains isolated in Poland by multilocus sequence typing.
Microbial drug resistance (Larchmont, N.Y.) 2003;9(1):81-6.
2003: Emma Meats; Angela B Brueggemann; Mark Enright; Karen L Sleeman; David T Griffiths; Derrick W Crook; Brian G Spratt
Stability of serotypes during nasopharyngeal carriage of Streptococcus pneumoniae.
Journal of clinical microbiology 2003;41(1):386-92.
2002: Mark Enright; D Ashley Robinson; Gaynor Randle; Edward J Feil; Hajo Grundmann; Brian G Spratt
The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA).
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7687-92.
2002: Awdhesh Kalia; Brian G Spratt; Mark Enright; Debra E Bessen
Influence of recombination and niche separation on the population genetic structure of the pathogen Streptococcus pyogenes.
Infection and immunity 2002;70(4):1971-83.
2002: Nicholas P J Day; Catrin E Moore; Mark Enright; Anthony P Berendt; John Maynard Smith; Michael F Murphy; Sharon J Peacock; Brian G Spratt; Edward J Feil
Retraction.
Science (New York, N.Y.) 2002;295(5557):971.
2001: Man-Suen Chan; Martin C J Maiden; Brian G Spratt
Database-driven multi locus sequence typing (MLST) of bacterial pathogens.
Bioinformatics (Oxford, England) 2001;17(11):1077-83.
2001: Brian G Spratt; William P Hanage; Edward J Feil
The relative contributions of recombination and point mutation to the diversification of bacterial clones.
Current opinion in microbiology 2001;4(5):602-6.
2001: Awdhesh Kalia; Mark Enright; Brian G Spratt; Debra E Bessen
Directional gene movement from human-pathogenic to commensal-like streptococci.
Infection and immunity 2001;69(8):4858-69.
2001: Nicholas P J Day; Catrin E Moore; Mark Enright; Anthony R Berendt; John Maynard Smith; Michael F Murphy; Sharon J Peacock; Brian G Spratt; Edward J Feil
A link between virulence and ecological abundance in natural populations of Staphylococcus aureus.
Science (New York, N.Y.) 2001;292(5514):114-6.
2001: Mark Enright; Brian G Spratt; Awdhesh Kalia; J H Cross; Debra E Bessen
Multilocus sequence typing of Streptococcus pyogenes and the relationships between emm type and clone.
Infection and immunity 2001;69(4):2416-27.
2001: Edward J Feil; Edward C Holmes; Debra E Bessen; Man-Suen Chan; Nicholas P J Day; Mark Enright; Richard Goldstein; Derek W Hood; Awdhesh Kalia; Catrin E Moore; J Zhou; Brian G Spratt
Recombination within natural populations of pathogenic bacteria: short-term empirical estimates and long-term phylogenetic consequences.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):182-7.
2001: Edward J Feil; Brian G Spratt
Recombination and the population structures of bacterial pathogens.
Annual review of microbiology 2001;55():561-90.
2000: Brian G Spratt; B M Greenwood
Prevention of pneumococcal disease by vaccination: does serotype replacement matter?
Lancet 2000;356(9237):1210-1.
2000: Mark Enright; Kyle Knox; David Griffiths; Derrick W Crook; Brian G Spratt
Molecular typing of bacteria directly from cerebrospinal fluid.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2000;19(8):627-30.
2000: Edward J Feil; Mark Enright; Brian G Spratt
Estimating the relative contributions of mutation and recombination to clonal diversification: a comparison between Neisseria meningitidis and Streptococcus pneumoniae.
Research in microbiology 2000;151(6):465-9.
2000: Julian Parkhill; Mark Achtman; Keith D James; Stephen Bentley; Carol Churcher; S R Klee; G Morelli; D Basham; D Brown; Tracey Chillingworth; R M Davies; P Davis; K Devlin; Theresa Feltwell; Nancy Hamlin; Simon Holroyd; Kay Jagels; S Leather; Sharon Moule; Karen Mungall; Michael A Quail; Marie-Adele Rajandream; Kim Rutherford; Mark Simmonds; Jason Skelton; Sally Whitehead; Brian G Spratt; Bart Barrell
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491.
Nature 2000;404(6777):502-6.
2000: Mark Enright; Nicholas P J Day; C E Davies; S J Peacock; Brian G Spratt
Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus.
Journal of clinical microbiology 2000;38(3):1008-15.
2000: J Zhou; Mark Enright; Brian G Spratt
Identification of the major Spanish clones of penicillin-resistant pneumococci via the Internet using multilocus sequence typing.
Journal of clinical microbiology 2000;38(3):977-86.
1999: Lucas D Bowler; Mike Hubank; Brian G Spratt
Representational difference analysis of cDNA for the detection of differential gene expression in bacteria: development using a model of iron-regulated gene expression in Neisseria meningitidis.
Microbiology (Reading, England) 1999;145 ( Pt 12)():3529-37.
1999: Mark Enright; Brian G Spratt
Extensive variation in the ddl gene of penicillin-resistant Streptococcus pneumoniae results from a hitchhiking effect driven by the penicillin-binding protein 2b gene.
Molecular biology and evolution 1999;16(12):1687-95.
1999: Mark Enright; Brian G Spratt
Multilocus sequence typing.
Trends in microbiology 1999;7(12):482-7.
1999: Edward J Feil; Martin C J Maiden; Mark Achtman; Brian G Spratt
The relative contributions of recombination and mutation to the divergence of clones of Neisseria meningitidis.
Molecular biology and evolution 1999;16(11):1496-502.
1999: Mark Enright; Asunción Fenoll; David Griffiths; Brian G Spratt
The three major Spanish clones of penicillin-resistant Streptococcus pneumoniae are the most common clones recovered in recent cases of meningitis in Spain.
Journal of clinical microbiology 1999;37(10):3210-6.
1999: Martin C J Maiden; Brian G Spratt
Meningococcal conjugate vaccines: new opportunities and new challenges.
Lancet 1999;354(9179):615-6.
1999: TJ Coffey; M Daniels; Mark Enright; Brian G Spratt
Serotype 14 variants of the Spanish penicillin-resistant serotype 9V clone of Streptococcus pneumoniae arose by large recombinational replacements of the cpsA-pbp1a region.
Microbiology (Reading, England) 1999;145 ( Pt 8)():2023-31.
1999: Brian G Spratt
Multilocus sequence typing: molecular typing of bacterial pathogens in an era of rapid DNA sequencing and the internet.
Current opinion in microbiology 1999;2(3):312-6.
1999: Noel Smith; E C Holmes; G M Donovan; G A Carpenter; Brian G Spratt
Networks and groups within the genus Neisseria: analysis of argF, recA, rho, and 16S rRNA sequences from human Neisseria species.
Molecular biology and evolution 1999;16(6):773-83.
1999: Brian G Spratt; M C Maiden
Bacterial population genetics, evolution and epidemiology.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1384):701-10.
1999: Judy K Morona; David Miller; TJ Coffey; Christofer J Vindurampulle; Brian G Spratt; Renato Morona; James C Paton
Molecular and genetic characterization of the capsule biosynthesis locus of Streptococcus pneumoniae type 23F.
Microbiology (Reading, England) 1999;145 ( Pt 4)():781-9.
1998: Z Y Shi; Mark Enright; P Wilkinson; D Griffiths; Brian G Spratt
Identification of three major clones of multiply antibiotic-resistant Streptococcus pneumoniae in Taiwanese hospitals by multilocus sequence typing.
Journal of clinical microbiology 1998;36(12):3514-9.
1998: Mark Enright; Brian G Spratt
A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease.
Microbiology (Reading, England) 1998;144 ( Pt 11)():3049-60.
1998: Martin C J Maiden; Jane A Bygraves; Edward J Feil; Giovanna Morelli; Joanne E Russell; Rachel Urwin; Q Zhang; J Zhou; K Zurth; DA Caugant; Ian M Feavers; Mark Achtman; Brian G Spratt
Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):3140-5.
1998: TJ Coffey; Mark Enright; M Daniels; P Wilkinson; Sonsoles Berrón; Asunción Fenoll; Brian G Spratt
Serotype 19A variants of the Spanish serotype 23F multiresistant clone of Streptococcus pneumoniae.
Microbial drug resistance (Larchmont, N.Y.) 1998;4(1):51-5.
1998: TJ Coffey; Mark Enright; M Daniels; Judy K Morona; Renato Morona; W Hryniewicz; James C Paton; Brian G Spratt
Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae.
Molecular microbiology 1998;27(1):73-83.
1997: J Zhou; Lucas D Bowler; Brian G Spratt
Interspecies recombination, and phylogenetic distortions, within the glutamine synthetase and shikimate dehydrogenase genes of Neisseria meningitidis and commensal Neisseria species.
Molecular microbiology 1997;23(4):799-812.
1997: T S Gutjahr; M O'Rourke; C A Ison; Brian G Spratt
Arginine-, hypoxanthine-, uracil-requiring isolates of Neisseria gonorrhoeae are a clonal lineage with a non-clonal population.
Microbiology (Reading, England) 1997;143 ( Pt 2)():633-40.
1996: E Feil; J Zhou; J Maynard Smith; Brian G Spratt
A comparison of the nucleotide sequences of the adk and recA genes of pathogenic and commensal Neisseria species: evidence for extensive interspecies recombination within adk.
Journal of molecular evolution 1996;43(6):631-40.
1996: Brian G Spratt
Antibiotic resistance: counting the cost.
Current biology : CB 1996;6(10):1219-21.
1996: TJ Coffey; Sonsoles Berrón; M Daniels; M E Garcia-Leoni; Emilia Cercenado; Emilio Bouza; Asunción Fenoll; Brian G Spratt
Multiply antibiotic-resistant Streptococcus pneumoniae recovered from Spanish hospitals (1988-1994): novel major clones of serotypes 14, 19F and 15F.
Microbiology (Reading, England) 1996;142 ( Pt 10)():2747-57.
1995: E Feil; G Carpenter; Brian G Spratt
Electrophoretic variation in adenylate kinase of Neisseria meningitidis is due to inter- and intraspecies recombination.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10535-9.
1995: M O'Rourke; C A Ison; Adrian Renton; Brian G Spratt
Opa-typing: a high-resolution tool for studying the epidemiology of gonorrhoea.
Molecular microbiology 1995;17(5):865-75.
1995: TJ Coffey; M Daniels; Linda McDougal; Christopher G Dowson; Fred C Tenover; Brian G Spratt
Genetic analysis of clinical isolates of Streptococcus pneumoniae with high-level resistance to expanded-spectrum cephalosporins.
Antimicrobial agents and chemotherapy 1995;39(6):1306-13.
1995: Noel Smith; J Maynard Smith; Brian G Spratt
Sequence evolution of the porB gene of Neisseria gonorrhoeae and Neisseria meningitidis: evidence of positive Darwinian selection.
Molecular biology and evolution 1995;12(3):363-70.
1995: Julio A Vázquez; Sonsoles Berrón; M O'Rourke; G Carpenter; E Feil; Noel Smith; Brian G Spratt
Interspecies recombination in nature: a meningococcus that has acquired a gonococcal PIB porin.
Molecular microbiology 1995;15(6):1001-7.
1995: TJ Coffey; Christopher G Dowson; M Daniels; Brian G Spratt
Genetics and molecular biology of beta-lactam-resistant pneumococci.
Microbial drug resistance (Larchmont, N.Y.) 1995;1(1):29-34.
1994: Christopher G Dowson; TJ Coffey; Brian G Spratt
Origin and molecular epidemiology of penicillin-binding-protein-mediated resistance to beta-lactam antibiotics.
Trends in microbiology 1994;2(10):361-6.
1994: M O'Rourke; Brian G Spratt
Further evidence for the non-clonal population structure of Neisseria gonorrhoeae: extensive genetic diversity within isolates of the same electrophoretic type.
Microbiology (Reading, England) 1994;140 ( Pt 6)():1285-90.
1994: Brian G Spratt
Resistance to antibiotics mediated by target alterations.
Science (New York, N.Y.) 1994;264(5157):388-93.
1994: W Pan; Brian G Spratt
Regulation of the permeability of the gonococcal cell envelope by the mtr system.
Molecular microbiology 1994;11(4):769-75.
1994: Lucas D Bowler; Q Y Zhang; J Y Riou; Brian G Spratt
Interspecies recombination between the penA genes of Neisseria meningitidis and commensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: natural events and laboratory simulation.
Journal of bacteriology 1994;176(2):333-7.
1993: C M Kell; J Z Jordens; M Daniels; TJ Coffey; J Bates; J Paul; C Gilks; Brian G Spratt
Molecular epidemiology of penicillin-resistant pneumococci isolated in Nairobi, Kenya.
Infection and immunity 1993;61(10):4382-91.
1993: Julio A Vázquez; Laura De La Fuente; S Berron; M O'Rourke; Noel Smith; J Zhou; Brian G Spratt
Ecological separation and genetic isolation of Neisseria gonorrhoeae and Neisseria meningitidis.
Current biology : CB 1993;3(9):567-72.
1993: TJ Coffey; Christopher G Dowson; M Daniels; Brian G Spratt
Horizontal spread of an altered penicillin-binding protein 2B gene between Streptococcus pneumoniae and Streptococcus oralis.
FEMS microbiology letters 1993;110(3):335-9.
1993: J M Smith; Noel Smith; M O'Rourke; Brian G Spratt
How clonal are bacteria?
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4384-8.
1993: C M Kell; U K Sharma; Christopher G Dowson; C Town; T S Balganesh; Brian G Spratt
Deletion analysis of the essentiality of penicillin-binding proteins 1A, 2B and 2X of Streptococcus pneumoniae.
FEMS microbiology letters 1993;106(2):171-5.
1992: Brian G Spratt
Re-emergence of the captain of the men of death.
Current biology : CB 1992;2(10):533-5.
1992: R Muñoz; Christopher G Dowson; M Daniels; TJ Coffey; C Martin; Regine Hakenbeck; Brian G Spratt
Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae.
Molecular microbiology 1992;6(17):2461-5.
1992: J Zhou; Brian G Spratt
Sequence diversity within the argF, fbp and recA genes of natural isolates of Neisseria meningitidis: interspecies recombination within the argF gene.
Molecular microbiology 1992;6(15):2135-46.
1992: J Campos; M C Fusté; G Trujillo; Juan Antonio Sáez-Nieto; J Vázquez; J Gaspar Lorén; Marc Viñas; Brian G Spratt
Genetic diversity of penicillin-resistant Neisseria meningitidis.
The Journal of infectious diseases 1992;166(1):173-7.
1992: Brian G Spratt; Lucas D Bowler; Q Y Zhang; J Zhou; J M Smith
Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species.
Journal of molecular evolution 1992;34(2):115-25.
1991: M Adam; C Damblon; M Jamin; Willy Zorzi; V Dusart; Moreno Galleni; A el Kharroubi; G Piras; Brian G Spratt; W Keck
Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins.
The Biochemical journal 1991;279 ( Pt 2)():601-4.
1991: J Brannigan; Alain Matagne; F Jacob; C Damblon; Bernard Joris; D Klein; Brian G Spratt; Jean-Marie Frère
The mutation Lys234His yields a class A beta-lactamase with a novel pH-dependence.
The Biochemical journal 1991;278 ( Pt 3)():673-8.
1991: TJ Coffey; Christopher G Dowson; M Daniels; J Zhou; C Martin; Brian G Spratt; J M Musser
Horizontal transfer of multiple penicillin-binding protein genes, and capsular biosynthetic genes, in natural populations of Streptococcus pneumoniae.
Molecular microbiology 1991;5(9):2255-60.
1991: R Muñoz; TJ Coffey; M Daniels; Christopher G Dowson; G Laible; J Casal; Regine Hakenbeck; M Jacobs; J M Musser; Brian G Spratt
Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae.
The Journal of infectious diseases 1991;164(2):302-6.
1991: G Laible; Brian G Spratt; Regine Hakenbeck
Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.
Molecular microbiology 1991;5(8):1993-2002.
1991: R Lujan; Q Y Zhang; Juan Antonio Sáez-Nieto; D M Jones; Brian G Spratt
Penicillin-resistant isolates of Neisseria lactamica produce altered forms of penicillin-binding protein 2 that arose by interspecies horizontal gene transfer.
Antimicrobial agents and chemotherapy 1991;35(2):300-4.
1991: J M Smith; Christopher G Dowson; Brian G Spratt
Localized sex in bacteria.
Nature 1991;349(6304):29-31.
1990: Christopher G Dowson; A Hutchison; Neil Woodford; A P Johnson; R C George; Brian G Spratt
Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5858-62.
1990: Q Y Zhang; D M Jones; Juan Antonio Sáez-Nieto; E Pérez Trallero; Brian G Spratt
Genetic diversity of penicillin-binding protein 2 genes of penicillin-resistant strains of Neisseria meningitidis revealed by fingerprinting of amplified DNA.
Antimicrobial agents and chemotherapy 1990;34(8):1523-8.
1990: J A Brannigan; I A Tirodimos; Q Y Zhang; Christopher G Dowson; Brian G Spratt
Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae.
Molecular microbiology 1990;4(6):913-9.
1989: J K Broome-Smith; Lucas D Bowler; Brian G Spratt
A simple method for maximizing the yields of membrane and exported proteins expressed in Escherichia coli.
Molecular microbiology 1989;3(12):1813-7.
1989: Christopher G Dowson; A Hutchison; J A Brannigan; R C George; D Hansman; J Liñares; A Tomasz; J M Smith; Brian G Spratt
Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8842-6.
1989: Brian G Spratt; Q Y Zhang; D M Jones; A Hutchison; J A Brannigan; Christopher G Dowson
Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(22):8988-92.
1989: Christopher G Dowson; A Hutchison; Brian G Spratt
Nucleotide sequence of the penicillin-binding protein 2B gene of Streptococcus pneumoniae strain R6.
Nucleic acids research 1989;17(18):7518.
1989: Lucas D Bowler; Brian G Spratt
Membrane topology of penicillin-binding protein 3 of Escherichia coli.
Molecular microbiology 1989;3(9):1277-86.
1989: Q Y Zhang; Brian G Spratt
Nucleotide sequence of the penicillin-binding protein 2 gene of Neisseria meningitidis.
Nucleic acids research 1989;17(13):5383.
1989: Christopher G Dowson; A Hutchison; Brian G Spratt
Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae.
Molecular microbiology 1989;3(1):95-102.
1989: Christopher G Dowson; A E Jephcott; K R Gough; Brian G Spratt
Penicillin-binding protein 2 genes of non-beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae.
Molecular microbiology 1989;3(1):35-41.
1988: Brian G Spratt; K D Cromie
Penicillin-binding proteins of gram-negative bacteria.
Reviews of infectious diseases 1988;10(4):699-711.
1988: Brian G Spratt
Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae.
Nature 1988;332(6160):173-6.
1988: J K Broome-Smith; I Ioannidis; A Edelman; Brian G Spratt
Nucleotide sequences of the penicillin-binding protein 5 and 6 genes of Escherichia coli.
Nucleic acids research 1988;16(4):1617.
1987: A Edelman; Lucas D Bowler; J K Broome-Smith; Brian G Spratt
Use of a beta-lactamase fusion vector to investigate the organization of penicillin-binding protein 1B in the cytoplasmic membrane of Escherichia coli.
Molecular microbiology 1987;1(1):101-6.
1986: Brian G Spratt; P J Hedge; S te Heesen; A Edelman; J K Broome-Smith
Kanamycin-resistant vectors that are analogues of plasmids pUC8, pUC9, pEMBL8 and pEMBL9.
Gene 1986;41(2-3):337-42.
1985: J K Broome-Smith; A Edelman; S Yousif; Brian G Spratt
The nucleotide sequences of the ponA and ponB genes encoding penicillin-binding protein 1A and 1B of Escherichia coli K12.
European journal of biochemistry / FEBS 1985;147(2):437-46.
1985: J K Broome-Smith; P J Hedge; Brian G Spratt
Production of thiol-penicillin-binding protein 3 of Escherichia coli using a two primer method of site-directed mutagenesis.
The EMBO journal 1985;4(1):231-5.
1983: neil stoker; J K Broome-Smith; A Edelman; Brian G Spratt
Organization and subcloning of the dacA-rodA-pbpA cluster of cell shape genes in Escherichia coli.
Journal of bacteriology 1983;155(2):847-53.