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Martin Springer

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Mingjuan J Luo; Qi Luo; Milana M Maletic; Lorraine Malkowitz; Andrew Plump; Kashmira Shah; Irwin Singer; Martin S Springer; Serguei Stepaniants; Rolf Thieringer; Sherman T Waddell; James M Balkovec; Kang Cheng; Gloria J Ding; Cheryl B Le Grand; Anne Hermanowski-Vosatka; Douglas W Kawka; Gloria C Koo; Pek Yee Lum; Samuel D Wright; Kenneth K Wu; Xia Yang; Jeffrey Yuan; Jun Zhu; I-Ming Wang
11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
Liwen Zhang; Yuchen Zhou; Amber Ying Zhu; Martin S Springer; Magdalena Alonso-Galicia; Bruce L Daugherty; Ling Gao; Melba Hernandez; Xiang-qing Li; JeanMarie Lisnock; Steven S Mundt; Edward A O'Neill; Oscar Puig
Metabolic syndrome in mice induced by expressing a transcriptional activator in adipose tissue.
Susan D Aster; Donald W Graham; Divya Kharbanda; Gool Patel; Mitree Ponpipom; Gina M Santorelli; Michael J Szymonifka; Steven S Mundt; Kashmira Shah; Martin S Springer; Rolf Thieringer; Anne Hermanowski-Vosatka; Samuel D Wright; Jianying Xiao; Hratch Zokian; James M Balkovec
Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

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2013: Mingjuan J Luo; Qi Luo; Milana M Maletic; Lorraine Malkowitz; Andrew Plump; Kashmira Shah; Irwin Singer; Martin S Springer; Serguei Stepaniants; Rolf Thieringer; Sherman T Waddell; James M Balkovec; Kang Cheng; Gloria J Ding; Cheryl B Le Grand; Anne Hermanowski-Vosatka; Douglas W Kawka; Gloria C Koo; Pek Yee Lum; Samuel D Wright; Kenneth K Wu; Xia Yang; Jeffrey Yuan; Jun Zhu; I-Ming Wang
11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
Physiological genomics 2013;45(1):47-57.
2012: Liwen Zhang; Yuchen Zhou; Amber Ying Zhu; Martin S Springer; Magdalena Alonso-Galicia; Bruce L Daugherty; Ling Gao; Melba Hernandez; Xiang-qing Li; JeanMarie Lisnock; Steven S Mundt; Edward A O'Neill; Oscar Puig
Metabolic syndrome in mice induced by expressing a transcriptional activator in adipose tissue.
Transgenic research 2012;21(3):633-44.
2008: Susan D Aster; Donald W Graham; Divya Kharbanda; Gool Patel; Mitree Ponpipom; Gina M Santorelli; Michael J Szymonifka; Steven S Mundt; Kashmira Shah; Martin S Springer; Rolf Thieringer; Anne Hermanowski-Vosatka; Samuel D Wright; Jianying Xiao; Hratch Zokian; James M Balkovec
Bis-aryl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Bioorganic & medicinal chemistry letters 2008;18(9):2799-804.
2007: Carsten Schröder; Richard N Pierson III; Bao-Ngoc H Nguyen; Douglas W Kawka; Laurence B Peterson; Guosheng Wu; Tianshu Zhang; Martin S Springer; Salvatore J Siciliano; Susan Iliff; Julia Ayala; Min Lu; John S Mudgett; Kathy Lyons; Sander G Mills; Geraldine G Miller; Irwin I Singer; Agnes M Azimzadeh; Julie A DeMartino
CCR5 blockade modulates inflammation and alloimmunity in primates.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2289-99.
2007: Changyou Zhou; Liangqin Guo; William H Parsons; Sander G Mills; Malcolm MacCoss; Pasquale P Vicario; Hans Zweerink; Margaret A Cascieri; Martin S Springer; Lihu Yang
Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists.
Bioorganic & medicinal chemistry letters 2007;17(2):309-14.
2006: Lihu Yang; Changyou Zhou; Liangqin Guo; Gregori J Morriello; Gabor Butora; Alexander Pasternak; William H Parsons; Sander G Mills; Malcolm MacCoss; Pasquale P Vicario; Hans Zweerink; Julia Ayala; Shefali Goyal; William A Hanlon; Margaret A Cascieri; Martin S Springer
Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.
Bioorganic & medicinal chemistry letters 2006;16(14):3735-9.
2005: Ronald S Veazey; Martin S Springer; Preston A Marx; Jason Dufour; Per Johan Klasse; John P Moore
Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.
Nature medicine 2005;11(12):1293-4.
2005: Xin Gu; Jasminka Dragovic; Gloria C Koo; Sam L Koprak; Cheryl LeGrand; Steven S Mundt; Kashmira Shah; Martin S Springer; Eugene Y Tan; Rolf Thieringer; Anne Hermanowski-Vosatka; Hratch J Zokian; James M Balkovec; Sherman T Waddell
Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome.
Bioorganic & medicinal chemistry letters 2005;15(23):5266-9.
2005: Ronald S Veazey; Per Johan Klasse; Susan M Schader; Qinxue Hu; Thomas J Ketas; Min Lu; Preston A Marx; Jason Dufour; Richard J Colonno; Robin J Shattock; Martin S Springer; John P Moore
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion.
Nature 2005;438(7064):99-102.
2005: Anne Hermanowski-Vosatka; James M Balkovec; Kang Cheng; Howard Y Chen; Melba Hernandez; Gloria C Koo; Cheryl B Le Grand; Zhihua Li; Joseph M Metzger; Steven S Mundt; Heather Noonan; Christian N Nunes; Steven H Olson; Bill Pikounis; Ning Ren; Nancy Robertson; James M Schaeffer; Kashmira Shah; Martin S Springer; Alison M Strack; Matthias Strowski; Kenneth Wu; Tsueiju Wu; Jianying Xiao; Bei B Zhang; Samuel D Wright; Rolf Thieringer
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.
The Journal of experimental medicine 2005;202(4):517-27.
2005: Dooseop Kim; Liping Wang; Jeffrey J Hale; Christopher L Lynch; Richard J Budhu; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee C Hrin; Gwen Carver; Anthony Carella; Karen Henry; Janet Lineberger; William A Schleif; Emilio A Emini
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Bioorganic & medicinal chemistry letters 2005;15(8):2129-34.
2005: Shrenik K Shah; Natalie Chen; Ravindra N Guthikonda; Sander G Mills; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini; Malcolm MacCoss
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane.
Bioorganic & medicinal chemistry letters 2005;15(4):977-82.
2005: Jianming Bao; Shouwu Miao; Frank Kayser; Andrew Kotliar; Robert K Baker; George A Doss; John P Felix; Randal M Bugianesi; Robert S Slaughter; Gregory J Kaczorowski; Maria L Garcia; Sookhee N Ha; Laurie A Castonguay; Gloria C Koo; Kashmira Shah; Martin S Springer; Mary Jo Staruch; William H Parsons; Kathleen M Rupprecht
Potent Kv1.3 inhibitors from correolide-modification of the C18 position.
Bioorganic & medicinal chemistry letters 2005;15(2):447-51.
2004: Steven Wolinsky; Ronald S Veazey; Kevin Kunstman; Per Johan Klasse; Jason Dufour; Andre J Marozsan; Martin S Springer; John P Moore
Effect of a CCR5 inhibitor on viral loads in macaques dual-infected with R5 and X4 primate immunodeficiency viruses.
Virology 2004;328(1):19-29.
2004: K Shankaran; Karla L Donnelly; Shrenik K Shah; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Julie A DeMartino; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Gloria Y Kwei; Anthony Carella; Gwen Carver; Renee Danzeisen; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.
Bioorganic & medicinal chemistry letters 2004;14(13):3589-93.
2004: K Shankaran; Karla L Donnelly; Shrenik K Shah; Ravindra N Guthikonda; Malcolm MacCoss; Sander G Mills; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Anthony Carella; Gwen Carver; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor.
Bioorganic & medicinal chemistry letters 2004;14(13):3419-24.
2004: Hiranthi Jayasuriya; Kithsiri B Herath; John G Ondeyka; Jon D Polishook; Gerald F Bills; Anne W Dombrowski; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; Manuel Sanchez; Ziqiang Guan; Suroojnauth Tiwari; Dennis W Stevenson; Robert P Borris; Sheo B Singh
Isolation and structure of antagonists of chemokine receptor (CCR5).
Journal of natural products 2004;67(6):1036-8.
2004: Min Shu; Jennifer L Loebach; Kerry A Parker; Sander G Mills; Kevin Chapman; Dong-Ming Shen; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Jerry Di Salvo; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
Bioorganic & medicinal chemistry letters 2004;14(4):947-52.
2004: Dong-Ming Shen; Min Shu; Christopher A Willoughby; Shrenik Shah; Christopher L Lynch; Jeffrey J Hale; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.
Bioorganic & medicinal chemistry letters 2004;14(4):941-5.
2004: Dong-Ming Shen; Min Shu; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.
Bioorganic & medicinal chemistry letters 2004;14(4):935-9.
2003: Ronald S Veazey; Per Johan Klasse; Thomas J Ketas; Jacqueline D Reeves; Michael Piatak; Kevin Kunstman; Shawn E Kuhmann; Preston A Marx; Jeffrey D Lifson; Jason Dufour; Megan Mefford; Ivona Pandrea; Steven Wolinsky; Robert W Doms; Julie A DeMartino; Salvatore J Siciliano; Kathy Lyons; Martin S Springer; John P Moore
Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.
The Journal of experimental medicine 2003;198(10):1551-62.
2003: Christopher L Lynch; Jeffrey J Hale; Richard J Budhu; Amy L Gentry; Paul E Finke; Charles G Caldwell; Sander G Mills; Malcolm MacCoss; Dong-Ming Shen; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity.
Organic letters 2003;5(14):2473-5.
2003: Shouwu Miao; Jianming Bao; Maria L Garcia; Joung L Goulet; Xingfang J Hong; Gregory J Kaczorowski; Frank Kayser; Gloria C Koo; Andrew Kotliar; william Schmalhofer; Kashmira Shah; Peter J Sinclair; Robert S Slaughter; Martin S Springer; Mary Jo Staruch; Nancy N Tsou; Frederick Wong; William H Parsons; Kathleen M Rupprecht
Benzamide derivatives as blockers of Kv1.3 ion channel.
Bioorganic & medicinal chemistry letters 2003;13(6):1161-4.
2003: Laurie A Castonguay; Youmin Weng; William Adolfsen; Jerry Di Salvo; Ruth Kilburn; Charles G Caldwell; Bruce L Daugherty; Paul E Finke; Jeffrey J Hale; Christopher L Lynch; Sander G Mills; Malcolm MacCoss; Martin S Springer; Julie A DeMartino
Binding of 2-aryl-4-(piperidin-1-yl)butanamines and 1,3,4-trisubstituted pyrrolidines to human CCR5: a molecular modeling-guided mutagenesis study of the binding pocket.
Biochemistry 2003;42(6):1544-50.
2003: Christopher A Willoughby; Keith G Rosauer; Jeffrey J Hale; Richard J Budhu; Sander G Mills; Kevin Chapman; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains.
Bioorganic & medicinal chemistry letters 2003;13(3):427-31.
2003: Christopher L Lynch; Christopher A Willoughby; Jeffrey J Hale; Edward J Holson; Richard J Budhu; Amy L Gentry; Keith G Rosauer; Charles G Caldwell; Ping Chen; Sander G Mills; Malcolm MacCoss; Scott Berk; Liya Chen; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.
Bioorganic & medicinal chemistry letters 2003;13(1):119-23.
2002: Christopher L Lynch; Jeffrey J Hale; Richard J Budhu; Amy L Gentry; Sander G Mills; Kevin Chapman; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorganic & medicinal chemistry letters 2002;12(20):3001-4.
2002: Jeffrey J Hale; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Sandra L Gould; Julie A DeMartino; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity.
Bioorganic & medicinal chemistry letters 2002;12(20):2997-3000.
2002: Liwen Zhang; Marco P Soares; Yanfen Guan; Stephen Matheravidathu; Richard Wnek; Kristine E Johnson; Anna Meisher; Susan A Iliff; John S Mudgett; Martin S Springer; Bruce L Daugherty
Functional expression and characterization of macaque C-C chemokine receptor 3 (CCR3) and generation of potent antagonistic anti-macaque CCR3 monoclonal antibodies.
The Journal of biological chemistry 2002;277(37):33799-810.
2002: Christopher L Lynch; Amy L Gentry; Jeffrey J Hale; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; George A Doss; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
Bioorganic & medicinal chemistry letters 2002;12(4):677-9.
2001: Christopher A Willoughby; Scott Berk; Keith G Rosauer; SJ Degrado; Kevin Chapman; Sandra L Gould; Martin S Springer; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
Combinatorial synthesis of CCR5 antagonists.
Bioorganic & medicinal chemistry letters 2001;11(24):3137-41.
2001: Dooseop Kim; Liping Wang; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Gwen Carver; Anthony Carella; Karen Holmes; Janet Lineberger; William A Schleif; Emilio A Emini
Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection.
Bioorganic & medicinal chemistry letters 2001;11(24):3103-6.
2001: Dooseop Kim; Liping Wang; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Lorraine Malkowitz; Sandra L Gould; Julie A DeMartino; Martin S Springer; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Gwen Carver; Anthony Carella; Karen Holmes; Janet Lineberger; William A Schleif; Emilio A Emini
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.
Bioorganic & medicinal chemistry letters 2001;11(24):3099-102.
2001: Jeffrey J Hale; Richard J Budhu; E B Holson; Paul E Finke; Bryan Oates; Sander G Mills; Malcolm MacCoss; Sandra L Gould; Julie A DeMartino; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity.
Bioorganic & medicinal chemistry letters 2001;11(20):2741-5.
2001: Paul E Finke; Bryan Oates; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(18):2475-9.
2001: Paul E Finke; Laura C Meurer; Bryan Oates; Shrenik K Shah; J L Loebach; Sander G Mills; Malcolm MacCoss; Laurie A Castonguay; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes.
Bioorganic & medicinal chemistry letters 2001;11(18):2469-73.
2001: Jeffrey J Hale; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Salvatore J Siciliano; Sandra L Gould; Julie A DeMartino; Martin S Springer
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements.
Bioorganic & medicinal chemistry letters 2001;11(11):1437-40.
2001: Irwin I Singer; S Scott; Douglas W Kawka; J Chin; Bruce L Daugherty; Julie A DeMartino; J DiSalvo; Sandra L Gould; Janet Lineberger; Lorraine Malkowitz; M D Miller; L Mitnaul; Salvatore J Siciliano; Mary Jo Staruch; HR Williams; Hans Zweerink; Martin S Springer
CCR5, CXCR4, and CD4 are clustered and closely apposed on microvilli of human macrophages and T cells.
Journal of virology 2001;75(8):3779-90.
2001: Paul E Finke; Laura C Meurer; Bryan Oates; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Bruce L Daugherty; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure-activity relationships for substituted 2-Aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(2):265-70.
2001: C P Dorn; Paul E Finke; Bryan Oates; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Bruce L Daugherty; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. part 1: discovery and initial structure-activity relationships for 1 -amino-2-phenyl-4-(piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(2):259-64.
2000: Jerry Di Salvo; Greg E Koch; K E Johnson; A D Blake; Bruce L Daugherty; Julie A DeMartino; A Sirotina-Meisher; Y Liu; Martin S Springer; Margaret A Cascieri; KA Sullivan
The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both Galpha(i)-coupled and uncoupled states.
European journal of pharmacology 2000;409(2):143-54.
1999: Salvatore J Siciliano; Shawn E Kuhmann; Y Weng; Navid Madani; Martin S Springer; Janet Lineberger; Renee Danzeisen; M D Miller; Michael P Kavanaugh; Julie A DeMartino; David Kabat
A critical site in the core of the CCR5 chemokine receptor required for binding and infectivity of human immunodeficiency virus type 1.
The Journal of biological chemistry 1999;274(4):1905-13.
1998: CM Hill; D Kwon; M Jones; C B Davis; Shana Marmon; Bruce L Daugherty; Julie A DeMartino; Martin S Springer; Derya Unutmaz; Dan R Littman
The amino terminus of human CCR5 is required for its function as a receptor for diverse human and simian immunodeficiency virus envelope glycoproteins.
Virology 1998;248(2):357-71.
1998: Y Weng; Salvatore J Siciliano; K E Waldburger; A Sirotina-Meisher; Mary Jo Staruch; Bruce L Daugherty; Sandra L Gould; Martin S Springer; Julie A DeMartino
Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
The Journal of biological chemistry 1998;273(29):18288-91.
1997: Sun Ying; Douglas S Robinson; Qiu Meng; J Rottman; R Kennedy; Douglas J Ringler; CR Mackay; Bruce L Daugherty; Martin S Springer; Stephen R Durham; Timothy J Williams; A Barry Kay
Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells.
European journal of immunology 1997;27(12):3507-16.
1997: Gloria C Koo; JT Blake; A Talento; M Nguyen; S Lin; A Sirotina; Kashmira Shah; K Mulvany; Donald F Hora; P Cunningham; Denise Wunderler; Owen B McManus; Robert S Slaughter; Randal M Bugianesi; J Felix; M Garcia; J Williamson; Gregory J Kaczorowski; NH Sigal; Martin S Springer; William P Feeney
Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5120-8.
1997: Bruce L Daugherty; Martin S Springer
The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21.
Genomics 1997;41(2):294-5.
1996: Bruce L Daugherty; Salvatore J Siciliano; Julie A DeMartino; L Malkowitz; A Sirotina; Martin S Springer
Cloning, expression, and characterization of the human eosinophil eotaxin receptor.
The Journal of experimental medicine 1996;183(5):2349-54.
1995: Julie A DeMartino; Z D Konteatis; Salvatore J Siciliano; G Van Riper; D J Underwood; P A Fischer; Martin S Springer
Arginine 206 of the C5a receptor is critical for ligand recognition and receptor activation by C-terminal hexapeptide analogs.
The Journal of biological chemistry 1995;270(27):15966-9.
1994: Z D Konteatis; Salvatore J Siciliano; G Van Riper; C J Molineaux; S Pandya; P Fischer; H Rosen; R A Mumford; Martin S Springer
Development of C5a receptor antagonists. Differential loss of functional responses.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(9):4200-5.
1994: Julie A DeMartino; G Van Riper; Salvatore J Siciliano; C J Molineaux; Z D Konteatis; H Rosen; Martin S Springer
The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.
The Journal of biological chemistry 1994;269(20):14446-50.
1994: G Van Riper; Donald W Nicholson; M P Scheid; P A Fischer; Martin S Springer; H Rosen
Induction, characterization, and functional coupling of the high affinity chemokine receptor for RANTES and macrophage inflammatory protein-1 alpha upon differentiation of an eosinophilic HL-60 cell line.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(8):4055-61.
1994: Salvatore J Siciliano; T E Rollins; Julie A DeMartino; Z Konteatis; L Malkowitz; G Van Riper; S Bondy; H Rosen; Martin S Springer
Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1214-8.
1993: R Meurer; G Van Riper; William P Feeney; P Cunningham; Donald F Hora; Martin S Springer; D E MacIntyre; H Rosen
Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 alpha, or human interleukin 8.
The Journal of experimental medicine 1993;178(6):1913-21.
1993: G Van Riper; Salvatore J Siciliano; P A Fischer; R Meurer; Martin S Springer; H Rosen
Characterization and species distribution of high affinity GTP-coupled receptors for human rantes and monocyte chemoattractant protein 1.
The Journal of experimental medicine 1993;177(3):851-6.
1993: C S Lin; R C Boltz; J T Blake; M Nguyen; A Talento; P A Fischer; Martin S Springer; Nolan Sigal; R S Slaughter; M L Garcia
Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation.
The Journal of experimental medicine 1993;177(3):637-45.
1993: A Talento; M Nguyen; T Blake; A Sirotina; C Fioravanti; D Burkholder; R Gibson; Nolan Sigal; Martin S Springer; Gloria C Koo
A single administration of LFA-1 antibody confers prolonged allograft survival.
Transplantation 1993;55(2):418-22.
1992: T J Lanza; P L Durette; T Rollins; Salvatore J Siciliano; D N Cianciarulo; S V Kobayashi; C G Caldwell; Martin S Springer; William K Hagmann
Substituted 4,6-diaminoquinolines as inhibitors of C5a receptor binding.
Journal of medicinal chemistry 1992;35(2):252-8.
1991: T E Rollins; Salvatore J Siciliano; S Kobayashi; D N Cianciarulo; V Bonilla-Argudo; K Collier; Martin S Springer
Purification of the active C5a receptor from human polymorphonuclear leukocytes as a receptor-Gi complex.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):971-5.
1990: Salvatore J Siciliano; T E Rollins; Martin S Springer
Interaction between the C5a receptor and Gi in both the membrane-bound and detergent-solubilized states.
The Journal of biological chemistry 1990;265(32):19568-74.
1988: T E Rollins; Salvatore J Siciliano; Martin S Springer
Solubilization of the functional C5a receptor from human polymorphonuclear leukocytes.
The Journal of biological chemistry 1988;263(1):520-6.
1985: T E Rollins; Martin S Springer
Identification of the polymorphonuclear leukocyte C5a receptor.
The Journal of biological chemistry 1985;260(12):7157-60.
1984: Martin S Springer; B Zanolari
Sensory transduction in Escherichia coli: regulation of the demethylation rate by the CheA protein.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(16):5061-5.
1983: T E Rollins; B Zanolari; Martin S Springer; Y Guindon; Robert Zamboni; Cheuk K Lau; J Rokach
Synthetic leukotriene B4 is a potent chemotaxin but a weak secretagogue for human PMN.
Prostaglandins 1983;25(2):281-9.
1982: Martin S Springer; B Zanolari; P A Pierzchala
Ordered methylation of the methyl-accepting chemotaxis proteins of Escherichia coli.
The Journal of biological chemistry 1982;257(12):6861-6.