Timothy Springer

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TOP 3
Zhang Xiaohui; Halvorsen Kenneth; Zhang Cheng-Zhong; Wong Wesley P; Springer Timothy A
Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor.
Luo Bing-Hao; Karanicolas John; Harmacek Laura D; Baker David; Springer Timothy A
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
Waldron Travis T; Springer Timothy A
Transmission of allostery through the lectin domain in selectin-mediated cell adhesion.

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All Publications

2009: Zhang Xiaohui; Halvorsen Kenneth; Zhang Cheng-Zhong; Wong Wesley P; Springer Timothy A
Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor.
Science (New York, N.Y.) 2009;324(5932):1330-4.
2009: Luo Bing-Hao; Karanicolas John; Harmacek Laura D; Baker David; Springer Timothy A
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
The Journal of biological chemistry 2009;284(6):3917-24.
2009: Waldron Travis T; Springer Timothy A
Transmission of allostery through the lectin domain in selectin-mediated cell adhesion.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):85-90.
2009: Springer Timothy A
Structural basis for selectin mechanochemistry.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):91-6.
2008: Zhu Jianghai; Luo Bing-Hao; Xiao Tsan; Zhang Chengzhong; Nishida Noritaka; Springer Timothy A
Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Molecular cell 2008;32(6):849-61.
2008: Mi Li-Zhi; Grey Michael J; Nishida Noritaka; Walz Thomas; Lu Chafen; Springer Timothy A
Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs.
Biochemistry 2008;47(39):10314-23.
2008: Springer Timothy A; Zhu Jianghai; Xiao Tsan
Structural basis for distinctive recognition of fibrinogen gammaC peptide by the platelet integrin alphaIIbbeta3.
The Journal of cell biology 2008;182(4):791-800.
2008: Zhang Hongmin; Casasnovas Jose M; Jin Moonsoo; Liu Jin-huan; Gahmberg Carl G; Springer Timothy A; Wang Jia-huai
An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5.
Molecular cell 2008;31(3):432-7.
2007: Vorup-Jensen Thomas; Chi Lianli; Gjelstrup Louise C; Jensen Uffe B; Jewett Craig A; Xie Can; Shimaoka Motomu; Linhardt Robert J; Springer Timothy A
Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin.
The Journal of biological chemistry 2007;282(42):30869-77.
2007: Zhu Jieqing; Carman Christopher V; Kim Minsoo; Shimaoka Motomu; Springer Timothy A; Luo Bing-Hao
Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.
Blood 2007;110(7):2475-83.
2007: Chen Xuehui; Kim Thomas Doohun; Carman Christopher V; Mi Li-Zhi; Song Gang; Springer Timothy A
Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(39):15358-63.
2007: Bonasio Roberto; Carman Christopher V; Kim Enoch; Sage Peter T; Love Kerry R; Mempel Thorsten R; Springer Timothy A; von Andrian Ulrich H
Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(37):14753-8.
2007: Vorup-Jensen Thomas; Waldron Travis T; Astrof Nathan; Shimaoka Motomu; Springer Timothy A
The connection between metal ion affinity and ligand affinity in integrin I domains.
Biochimica et biophysica acta 2007;1774(9):1148-55.
2007: Carman Christopher V; Sage Peter T; Sciuto Tracey E; de la Fuente Miguel A; Geha Raif S; Ochs Hans D; Dvorak Harold F; Dvorak Ann M; Springer Timothy A
Transcellular diapedesis is initiated by invasive podosomes.
Immunity 2007;26(6):784-97.
2007: Zhu Jieqing; Boylan Brian; Luo Bing-Hao; Newman Peter J; Springer Timothy A
Tests of the extension and deadbolt models of integrin activation.
The Journal of biological chemistry 2007;282(16):11914-20.
2007: Luo Bing-Hao; Carman Christopher V; Springer Timothy A
Structural basis of integrin regulation and signaling.
Annual review of immunology 2007;25():619-47.
2006: Nishida Noritaka; Walz Thomas; Springer Timothy A
Structural transitions of complement component C3 and its activation products.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19737-42.
2006: Astrof Nathan S; Salas Azucena; Shimaoka Motomu; Chen JianFeng; Springer Timothy A
Importance of force linkage in mechanochemistry of adhesion receptors.
Biochemistry 2006;45(50):15020-8.
2006: Yang Wei; Carman Christopher V; Kim Minsoo; Salas Azucena; Shimaoka Motomu; Springer Timothy A
A small molecule agonist of an integrin, alphaLbeta2.
The Journal of biological chemistry 2006;281(49):37904-12.
2006: Springer Timothy A
Complement and the multifaceted functions of VWA and integrin I domains.
Structure (London, England : 1993) 2006;14(11):1611-6.
2006: Nishida Noritaka; Xie Can; Shimaoka Motomu; Cheng Yifan; Walz Thomas; Springer Timothy A
Activation of leukocyte beta2 integrins by conversion from bent to extended conformations.
Immunity 2006;25(4):583-94.
2006: Luo Bing-Hao; Springer Timothy A
Integrin structures and conformational signaling.
Current opinion in cell biology 2006;18(5):579-86.
2006: Huang Lili; Shimaoka Motomu; Rondon Isaac J; Roy Illa; Chang Qing; Po Melody; Dransfield Daniel T; Ladner Robert C; Edge Albert S B; Salas Azucena; Wood Clive R; Springer Timothy A; Cohen Edward H
Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1.
Journal of leukocyte biology 2006;80(4):905-14.
2006: Shimaoka Motomu; Kim Minsoo; Cohen Edward H; Yang Wei; Astrof Nathan; Peer Dan; Salas Azucena; Ferrand Audrey; Springer Timothy A
AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):13991-6.
2006: Chen JianFeng; Yang Wei; Kim Minsoo; Carman Christopher V; Springer Timothy A
Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):13062-7.
2006: Phan Uyen T; Waldron Travis T; Springer Timothy A
Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force.
Nature immunology 2006;7(8):883-9.
2006: Jin Moonsoo; Song Gang; Carman Christopher V; Kim Yong-Sung; Astrof Nathan S; Shimaoka Motomu; Wittrup Dane K; Springer Timothy A
Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5758-63.
2006: Salas Azucena; Shimaoka Motomu; Phan Uyen; Kim Minsoo; Springer Timothy A
Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state.
The Journal of biological chemistry 2006;281(16):10876-82.
2006: Song Gang; Lazar Greg A; Kortemme Tanja; Shimaoka Motomu; Desjarlais John R; Baker David; Springer Timothy A
Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion.
The Journal of biological chemistry 2006;281(8):5042-9.
2005: Luo Bing-Hao; Carman Christopher V; Takagi Junichi; Springer Timothy A
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3679-84.
2005: Song Gang; Yang Yuting; Liu Jin-Huan; Casasnovas Jose M; Shimaoka Motomu; Springer Timothy A; Wang Jia-Huai
An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3366-71.
2005: Vorup-Jensen Thomas; Carman Christopher V; Shimaoka Motomu; Schuck Peter; Svitel Juraj; Springer Timothy A
Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1614-9.
2004: Kim Minsoo; Carman Christopher V; Yang Wei; Salas Azucena; Springer Timothy A
The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.
The Journal of cell biology 2004;167(6):1241-53.
2004: Jin Moonsoo; Andricioaei Ioan; Springer Timothy A
Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics.
Structure (London, England : 1993) 2004;12(12):2137-47.
2004: Chen JianFeng; Takagi Junichi; Xie Can; Xiao Tsan; Luo Bing-Hao; Springer Timothy A
The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7.
The Journal of biological chemistry 2004;279(53):55556-61.
2004: Xiao Tsan; Takagi Junichi; Coller Barry S; Wang Jia-Huai; Springer Timothy A
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics.
Nature 2004;432(7013):59-67.
2004: Carman Christopher V; Springer Timothy A
A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them.
The Journal of cell biology 2004;167(2):377-88.
2004: Xie Can; Shimaoka Motomu; Xiao Tsan; Schwab Pascale; Klickstein Lloyd B; Springer Timothy A
The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15422-7.
2004: Lu Chafen; Shimaoka Motomu; Salas Azucena; Springer Timothy A
The binding sites for competitive antagonistic, allosteric antagonistic, and agonistic antibodies to the I domain of integrin LFA-1.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3972-8.
2004: Luo Bing-Hao; Springer Timothy A; Takagi Junichi
A specific interface between integrin transmembrane helices and affinity for ligand.
PLoS biology 2004;2(6):e153.
2004: Luo Bing-Hao; Strokovich Konstantin; Walz Thomas; Springer Timothy A; Takagi Junichi
Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain.
The Journal of biological chemistry 2004;279(26):27466-71.
2004: Yang Yuting; Jun Chang-Duk; Liu Jin-Huan; Zhang Rongguang; Joachimiak Andrzej; Springer Timothy A; Wang Jia-Huai
Structural basis for dimerization of ICAM-1 on the cell surface.
Molecular cell 2004;14(2):269-76.
2004: Salas Azucena; Shimaoka Motomu; Kogan Avi N; Harwood Charlotte; von Andrian Ulrich H; Springer Timothy A
Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction.
Immunity 2004;20(4):393-406.
2004: Yang Wei; Shimaoka Motomu; Salas Azucena; Takagi Junichi; Springer Timothy A
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2906-11.
2004: Luo Bing-Hao; Takagi Junichi; Springer Timothy A
Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides.
The Journal of biological chemistry 2004;279(11):10215-21.
2004: Yang Wei; Shimaoka Motomu; Chen JianFeng; Springer Timothy A
Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2333-8.
2004: Shimaoka Motomu; Springer Timothy A
Therapeutic antagonists and the conformational regulation of the beta2 integrins.
Current topics in medicinal chemistry 2004;4(14):1485-95.
2004: Springer Timothy A; Wang Jia-Huai
The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion.
Advances in protein chemistry 2004;68():29-63.
2003: Carman Christopher V; Jun Chang-Duk; Salas Azucena; Springer Timothy A
Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6135-44.
2003: Chen JianFeng; Salas Azucena; Springer Timothy A
Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster.
Nature structural biology 2003;10(12):995-1001.
2003: Carman Christopher V; Springer Timothy A
Integrin avidity regulation: are changes in affinity and conformation underemphasized?
Current opinion in cell biology 2003;15(5):547-56.
2003: Kim Minsoo; Carman Christopher V; Springer Timothy A
Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins.
Science (New York, N.Y.) 2003;301(5640):1720-5.
2003: Shimaoka Motomu; Salas Azucena; Yang Wei; Weitz-Schmidt Gabriele; Springer Timothy A
Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other.
Immunity 2003;19(3):391-402.
2003: Takagi Junichi; Strokovich Konstantin; Springer Timothy A; Walz Thomas
Structure of integrin alpha5beta1 in complex with fibronectin.
The EMBO journal 2003;22(18):4607-15.
2003: Shimaoka Motomu; Springer Timothy A
Therapeutic antagonists and conformational regulation of integrin function.
Nature reviews. Drug discovery 2003;2(9):703-16.
2003: Luo Bing-Hao; Springer Timothy A; Takagi Junichi
High affinity ligand binding by integrins does not involve head separation.
The Journal of biological chemistry 2003;278(19):17185-9.
2003: Luo Bing-Hao; Springer Timothy A; Takagi Junichi
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2403-8.
2003: Vorup-Jensen Thomas; Ostermeier Christian; Shimaoka Motomu; Hommel Ulrich; Springer Timothy A
Structure and allosteric regulation of the alpha X beta 2 integrin I domain.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1873-8.
2003: Shimaoka Motomu; Xiao Tsan; Liu Jin-Huan; Yang Yuting; Dong Yicheng; Jun Chang-Duk; McCormack Alison; Zhang Rongguang; Joachimiak Andrzej; Takagi Junichi; Wang Jia-Huai; Springer Timothy A
Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.
Cell 2003;112(1):99-111.
2002: Springer Timothy A
Predicted and experimental structures of integrins and beta-propellers.
Current opinion in structural biology 2002;12(6):802-13.
2002: Shimaoka Motomu; Lu Chafen; Salas Azucena; Xiao Tsan; Takagi Junichi; Springer Timothy A
Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16737-41.
2002: Salas Azucena; Shimaoka Motomu; Chen Shuqi; Carman Christopher V; Springer Timothy
Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1.
The Journal of biological chemistry 2002;277(52):50255-62.
2002: Jing Hua; Takagi Junichi; Liu Jin-huan; Lindgren Sara; Zhang Rong-guang; Joachimiak A; Wang Jia-huai; Springer Timothy A
Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins.
Structure (London, England : 1993) 2002;10(10):1453-64.
2002: Takagi Junichi; Petre Benjamin M; Walz Thomas; Springer Timothy A
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling.
Cell 2002;110(5):599-11.
2002: Takagi Junichi; Springer Timothy A
Integrin activation and structural rearrangement.
Immunological reviews 2002;186():141-63.
2002: Springer Timothy A
César Milstein, the father of modern immunology.
Nature immunology 2002;3(6):501-3.
2002: Springer Timothy A
Immunology. Retrospective: César Milstein (1927-2002).
Science (New York, N.Y.) 2002;296(5571):1253.
2002: Takagi Junichi; DeBottis Daniel P; Erickson Harold P; Springer Timothy A
The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding.
Biochemistry 2002;41(13):4339-47.
2002: Beglova Natalia; Blacklow Stephen C; Takagi Junichi; Springer Timothy A
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.
Nature structural biology 2002;9(4):282-7.
2002: Ma Qing; Shimaoka Motomu; Lu Chafen; Jing Hua; Carman Christopher V; Springer Timothy A
Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1.
The Journal of biological chemistry 2002;277(12):10638-41.
2002: Shimaoka Motomu; Takagi Junichi; Springer Timothy A
Conformational regulation of integrin structure and function.
Annual review of biophysics and biomolecular structure 2002;31():485-516.
2001: de Château M; Chen S; Salas A; Springer T A
Kinetic and mechanical basis of rolling through an integrin and novel Ca2+-dependent rolling and Mg2+-dependent firm adhesion modalities for the alpha 4 beta 7-MAdCAM-1 interaction.
Biochemistry 2001;40(46):13972-9.
2001: Takagi J; Beglova N; Yalamanchili P; Blacklow S C; Springer T A
Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11175-80.
2001: Manjunath N; Shankar P; Wan J; Weninger W; Crowley M A; Hieshima K; Springer T A; Fan X; Shen H; Lieberman J; von Andrian U H
Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes.
The Journal of clinical investigation 2001;108(6):871-8.
2001: Jun C D; Carman C V; Redick S D; Shimaoka M; Erickson H P; Springer T A
Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1).
The Journal of biological chemistry 2001;276(31):29019-27.
2001: Smith R S; Fedyk E R; Springer T A; Mukaida N; Iglewski B H; Phipps R P
IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):366-74.
2001: Jun C D; Shimaoka M; Carman C V; Takagi J; Springer T A
Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6830-5.
2001: Jeon H; Meng W; Takagi J; Eck M J; Springer T A; Blacklow S C
Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
Nature structural biology 2001;8(6):499-504.
2001: Springer T A
Immunoaffinity chromatography.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 8():Unit 8.2.
2001: Shimaoka M; Lu C; Palframan R T; von Andrian U H; McCormack A; Takagi J; Springer T A
Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6009-14.
2001: Takagi J; Erickson H P; Springer T A
C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1.
Nature structural biology 2001;8(5):412-6.
2001: Fedyk E R; Jones D; Critchley H O; Phipps R P; Blieden T M; Springer T A
Expression of stromal-derived factor-1 is decreased by IL-1 and TNF and in dermal wound healing.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5749-54.
2001: Lu C; Ferzly M; Takagi J; Springer T A
Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5629-37.
2001: Lu C; Takagi J; Springer T A
Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state.
The Journal of biological chemistry 2001;276(18):14642-8.
2001: Zang Q; Springer T A
Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2).
The Journal of biological chemistry 2001;276(10):6922-9.
2001: Lu C; Shimaoka M; Zang Q; Takagi J; Springer T A
Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2393-8.
2001: Lu C; Shimaoka M; Ferzly M; Oxvig C; Takagi J; Springer T A
An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2387-92.
2001: Chen S; Springer T A
Selectin receptor-ligand bonds: Formation limited by shear rate and dissociation governed by the Bell model.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):950-5.
2000: Shimaoka M; Shifman J M; Jing H; Takagi J; Mayo S L; Springer T A
Computational design of an integrin I domain stabilized in the open high affinity conformation.
Nature structural biology 2000;7(8):674-8.
2000: Zang Q; Lu C; Huang C; Takagi J; Springer T A
The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3.
The Journal of biological chemistry 2000;275(29):22202-12.
2000: Huang C; Zang Q; Takagi J; Springer T A
Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain.
The Journal of biological chemistry 2000;275(28):21514-24.
2000: Yalamanchili P; Lu C; Oxvig C; Springer T A
Folding and function of I domain-deleted Mac-1 and lymphocyte function-associated antigen-1.
The Journal of biological chemistry 2000;275(29):21877-82.
1999: Fedyk E R; Ryyan D H; Ritterman I; Springer T A
Maturation decreases responsiveness of human bone marrow B lineage cells to stromal-derived factor 1 (SDF-1).
Journal of leukocyte biology 1999;66(4):667-73.
1999: Ma Q; Jones D; Springer T A
The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment.
Immunity 1999;10(4):463-71.
1999: Casasnovas J M; Pieroni C; Springer T A
Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3017-22.
1999: Oxvig C; Lu C; Springer T A
Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2215-20.
1999: Chen S; Springer T A
An automatic braking system that stabilizes leukocyte rolling by an increase in selectin bond number with shear.
The Journal of cell biology 1999;144(1):185-200.
1998: Weber C; Springer T A
Interaction of very late antigen-4 with VCAM-1 supports transendothelial chemotaxis of monocytes by facilitating lateral migration.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6825-34.
1998: Nagashima M; Shin'oka T; Nollert G; Shum-Tim D; Hickey P R; Roth S J; Kirchhoff A; Springer T A; Burke P R; Mayer J E
Effects of a monoclonal antibody to P-selectin on recovery of neonatal lamb hearts after cold cardioplegic ischemia.
Circulation 1998;98(19 Suppl):II391-7; discussion II397-8.
1998: Alon R; Chen S; Fuhlbrigge R; Puri K D; Springer T A
The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11631-6.
1998: Ma Q; Jones D; Borghesani P R; Segal R A; Nagasawa T; Kishimoto T; Bronson R T; Springer T A
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9448-53.
1998: Casasnovas J M; Bickford J K; Springer T A
The domain structure of ICAM-1 and the kinetics of binding to rhinovirus.
Journal of virology 1998;72(7):6244-6.
1998: Wang J; Springer T A
Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses.
Immunological reviews 1998;163():197-215.
1998: Tan K; Casasnovas J M; Liu J H; Briskin M J; Springer T A; Wang J H
The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition.
Structure (London, England : 1993) 1998;6(6):793-801.
1998: Lu C; Oxvig C; Springer T A
The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. Dependence on beta subunit association and prediction of domains.
The Journal of biological chemistry 1998;273(24):15138-47.
1998: Kitayama J; Mackay C R; Ponath P D; Springer T A
The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow.
The Journal of clinical investigation 1998;101(9):2017-24.
1998: Petruzzelli L; Maduzia L; Springer T A
Differential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4208-16.
1998: Puri K D; Chen S; Springer T A
Modifying the mechanical property and shear threshold of L-selectin adhesion independently of equilibrium properties.
Nature 1998;392(6679):930-3.
1998: Oxvig C; Springer T A
Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):4870-5.
1998: Casasnovas J M; Stehle T; Liu J H; Wang J H; Springer T A
A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4134-9.
1998: Piali L; Weber C; LaRosa G; Mackay C R; Springer T A; Clark-Lewis I; Moser B
The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig.
European journal of immunology 1998;28(3):961-72.
1998: Bleul C C; Schultze J L; Springer T A
B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement.
The Journal of experimental medicine 1998;187(5):753-62.
1998: Clark R A; Fuhlbrigge R C; Springer T A
L-Selectin ligands that are O-glycoprotease resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endothelial venules.
The Journal of cell biology 1998;140(3):721-31.
1998: Parolin C; Borsetti A; Choe H; Farzan M; Kolchinsky P; Heesen M; Ma Q; Gerard C; Palú G; Dorf M E; Springer T; Sodroski J
Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses.
Journal of virology 1998;72(2):1652-6.
1998: Roth S J; Diacovo T G; Brenner M B; Rosat J P; Buccola J; Morita C T; Springer T A
Transendothelial chemotaxis of human alpha/beta and gamma/delta T lymphocytes to chemokines.
European journal of immunology 1998;28(1):104-13.
1997: Weber C; Lu C F; Casasnovas J M; Springer T A
Role of alpha L beta 2 integrin avidity in transendothelial chemotaxis of mononuclear cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):3968-75.
1997: Kitayama J; Fuhlbrigge R C; Puri K D; Springer T A
P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):3929-39.
1997: Weber C; Springer T A
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor.
The Journal of clinical investigation 1997;100(8):2085-93.
1997: Alon R; Chen S; Puri K D; Finger E B; Springer T A
The kinetics of L-selectin tethers and the mechanics of selectin-mediated rolling.
The Journal of cell biology 1997;138(5):1169-80.
1997: Tanabe S; Heesen M; Yoshizawa I; Berman M A; Luo Y; Bleul C C; Springer T A; Okuda K; Gerard N; Dorf M E
Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):905-11.
1997: Lu C F; Springer T A
The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):268-78.
1997: Casasnovas J M; Springer T A; Liu J H; Harrison S C; Wang J H
Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.
Nature 1997;387(6630):312-5.
1997: Clark R A; Erickson H P; Springer T A
Tenascin supports lymphocyte rolling.
The Journal of cell biology 1997;137(3):755-65.
1997: Chen S; Alon R; Fuhlbrigge R C; Springer T A
Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3172-7.
1997: Huang C; Springer T A
Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3162-7.
1997: Huang C; Lu C; Springer T A
Folding of the conserved domain but not of flanking regions in the integrin beta2 subunit requires association with the alpha subunit.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3156-61.
1997: Bleul C C; Wu L; Hoxie J A; Springer T A; Mackay C R
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1925-30.
1997: Kitayama J; Carr M W; Roth S J; Buccola J; Springer T A
Contrasting responses to multiple chemotactic stimuli in transendothelial migration: heterologous desensitization in neutrophils and augmentation of migration in eosinophils.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2340-9.
1997: Aiuti A; Webb I J; Bleul C; Springer T; Gutierrez-Ramos J C
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.
The Journal of experimental medicine 1997;185(1):111-20.
1997: Springer T A
Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):65-72.
1997: Puri K D; Finger E B; Springer T A
The faster kinetics of L-selectin than of E-selectin and P-selectin rolling at comparable binding strength.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):405-13.
1996: Finger E B; Bruehl R E; Bainton D F; Springer T A
A differential role for cell shape in neutrophil tethering and rolling on endothelial selectins under flow.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5085-96.
1996: Alon R; Fuhlbrigge R C; Finger E B; Springer T A
Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow.
The Journal of cell biology 1996;135(3):849-65.
1996: Fuhlbrigge R C; Alon R; Puri K D; Lowe J B; Springer T A
Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions.
The Journal of cell biology 1996;135(3):837-48.
1996: Weber C; Kitayama J; Springer T A
Differential regulation of beta 1 and beta 2 integrin avidity by chemoattractants in eosinophils.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10939-44.
1996: Bleul C C; Fuhlbrigge R C; Casasnovas J M; Aiuti A; Springer T A
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
The Journal of experimental medicine 1996;184(3):1101-9.
1996: Klickstein L B; York M R; Fougerolles A R; Springer T A
Localization of the binding site on intercellular adhesion molecule-3 (ICAM-3) for lymphocyte function-associated antigen 1 (LFA-1).
The Journal of biological chemistry 1996;271(39):23920-7.
1996: Clark R A; Alon R; Springer T A
CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma.
The Journal of cell biology 1996;134(4):1075-87.
1996: Weber C; Alon R; Moser B; Springer T A
Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis.
The Journal of cell biology 1996;134(4):1063-73.
1996: Bruehl R E; Springer T A; Bainton D F
Quantitation of L-selectin distribution on human leukocyte microvilli by immunogold labeling and electron microscopy.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1996;44(8):835-44.
1996: Bleul C C; Farzan M; Choe H; Parolin C; Clark-Lewis I; Sodroski J; Springer T A
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.
Nature 1996;382(6594):829-33.
1996: Parkos C A; Colgan S P; Diamond M S; Nusrat A; Liang T W; Springer T A; Madara J L
Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: consequences for CD11b/CD18-mediated interactions with neutrophils.
Molecular medicine (Cambridge, Mass.) 1996;2(4):489-505.
1996: Diacovo T G; Roth S J; Buccola J M; Bainton D F; Springer T A
Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18.
Blood 1996;88(1):146-57.
1996: Diacovo T G; Puri K D; Warnock R A; Springer T A; von Andrian U H
Platelet-mediated lymphocyte delivery to high endothelial venules.
Science (New York, N.Y.) 1996;273(5272):252-5.
1996: Wong D A; Davis E M; LeBeau M; Springer T A
Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit.
Gene 1996;171(2):291-4.
1996: Diacovo T G; Roth S J; Morita C T; Rosat J P; Brenner M B; Springer T A
Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin.
The Journal of experimental medicine 1996;183(3):1193-203.
1996: Puri K D; Springer T A
A schiff base with mildly oxidized carbohydrate ligands stabilizes L-selectin and not P-selectin or E-selectin rolling adhesions in shear flow.
The Journal of biological chemistry 1996;271(10):5404-13.
1996: Dustin M L; Ferguson L M; Chan P Y; Springer T A; Golan D E
Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area.
The Journal of cell biology 1996;132(3):465-74.
1996: Girard J P; Springer T A
Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules.
The Journal of biological chemistry 1996;271(8):4511-7.
1996: Carr M W; Alon R; Springer T A
The C-C chemokine MCP-1 differentially modulates the avidity of beta 1 and beta 2 integrins on T lymphocytes.
Immunity 1996;4(2):179-87.
1996: Finger E B; Puri K D; Alon R; Lawrence M B; von Andrian U H; Springer T A
Adhesion through L-selectin requires a threshold hydrodynamic shear.
Nature 1996;379(6562):266-9.
1995: Roth S J; Carr M W; Springer T A
C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes.
European journal of immunology 1995;25(12):3482-8.
1995: Roth S J; Carr M W; Rose S S; Springer T A
Characterization of transendothelial chemotaxis of T lymphocytes.
Journal of immunological methods 1995;188(1):97-116.
1995: Puri K D; Finger E B; Gaudernack G; Springer T A
Sialomucin CD34 is the major L-selectin ligand in human tonsil high endothelial venules.
The Journal of cell biology 1995;131(1):261-70.
1995: Diamond M S; Alon R; Parkos C A; Quinn M T; Springer T A
Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1).
The Journal of cell biology 1995;130(6):1473-82.
1995: Huang C; Springer T A
A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1).
The Journal of biological chemistry 1995;270(32):19008-16.
1995: Petruzzelli L; Maduzia L; Springer T A
Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(2):854-66.
1995: Casasnovas J M; Springer T A
Kinetics and thermodynamics of virus binding to receptor. Studies with rhinovirus, intercellular adhesion molecule-1 (ICAM-1), and surface plasmon resonance.
The Journal of biological chemistry 1995;270(22):13216-24.
1995: Kassner P D; Alon R; Springer T A; Hemler M E
Specialized functional properties of the integrin alpha 4 cytoplasmic domain.
Molecular biology of the cell 1995;6(6):661-74.
1995: Alon R; Feizi T; Yuen C T; Fuhlbrigge R C; Springer T A
Glycolipid ligands for selectins support leukocyte tethering and rolling under physiologic flow conditions.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5356-66.
1995: de Fougerolles A R; Diamond M S; Springer T A
Heterogenous glycosylation of ICAM-3 and lack of interaction with Mac-1 and p150,95.
European journal of immunology 1995;25(4):1008-12.
1995: Lawrence M B; Berg E L; Butcher E C; Springer T A
Rolling of lymphocytes and neutrophils on peripheral node addressin and subsequent arrest on ICAM-1 in shear flow.
European journal of immunology 1995;25(4):1025-31.
1995: Alon R; Hammer D A; Springer T A
Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow.
Nature 1995;374(6522):539-42.
1995: Alon R; Kassner P D; Carr M W; Finger E B; Hemler M E; Springer T A
The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.
The Journal of cell biology 1995;128(6):1243-53.
1995: Girard J P; Springer T A
Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC.
Immunity 1995;2(1):113-23.
1995: Kinashi T; St Pierre Y; Springer T A
Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells.
Journal of leukocyte biology 1995;57(1):168-73.
1995: Springer T A
Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.
Annual review of physiology 1995;57():827-72.
1994: Diacovo T G; deFougerolles A R; Bainton D F; Springer T A
A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2.
The Journal of clinical investigation 1994;94(3):1243-51.
1994: Casasnovas J M; Springer T A
Pathway of rhinovirus disruption by soluble intercellular adhesion molecule 1 (ICAM-1): an intermediate in which ICAM-1 is bound and RNA is released.
Journal of virology 1994;68(9):5882-9.
1994: Xu H; Gonzalo J A; St Pierre Y; Williams I R; Kupper T S; Cotran R S; Springer T A; Gutierrez-Ramos J C
Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.
The Journal of experimental medicine 1994;180(1):95-109.
1994: Diamond M S; Springer T A
The dynamic regulation of integrin adhesiveness.
Current biology : CB 1994;4(6):506-17.
1994: Lawrence M B; Bainton D F; Springer T A
Neutrophil tethering to and rolling on E-selectin are separable by requirement for L-selectin.
Immunity 1994;1(2):137-45.
1994: Bilsland C A; Diamond M S; Springer T A
The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4582-9.
1994: Carr M W; Roth S J; Luther E; Rose S S; Springer T A
Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3652-6.
1994: Bilsland C A; Springer T A
Cloning and expression of the chicken CD18 cDNA.
Journal of leukocyte biology 1994;55(4):501-6.
1994: Vonderheide R H; Tedder T F; Springer T A; Staunton D E
Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4.
The Journal of cell biology 1994;125(1):215-22.
1994: Schlossman S F; Boumsell L; Gilks W; Harlan J M; Kishimoto T; Morimoto C; Ritz J; Shaw S; Silverstein R L; Springer T A
CD antigens 1993.
Blood 1994;83(4):879-80.
1994: de Fougerolles A R; Qin X; Springer T A
Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses.
The Journal of experimental medicine 1994;179(2):619-29.
1994: Schlossman S F; Boumsell L; Gilks W; Harlan J M; Kishimoto T; Morimoto C; Ritz J; Shaw S; Silverstein R L; Springer T A
CD antigens 1993.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(1):1-2.
1994: Springer T A
Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.
Cell 1994;76(2):301-14.
1994: Kinashi T; Springer T A
Adhesion molecules in hematopoietic cells.
Blood cells 1994;20(1):25-44.
1993: Lawrence M B; Springer T A
Neutrophils roll on E-selectin.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6338-46.
1993: Martin S; Martin A; Staunton D E; Springer T A
Functional studies of truncated soluble intercellular adhesion molecule 1 expressed in Escherichia coli.
Antimicrobial agents and chemotherapy 1993;37(6):1278-84.
1993: Martin S; Casasnovas J M; Staunton D E; Springer T A
Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules.
Journal of virology 1993;67(6):3561-8.
1993: de Fougerolles A R; Klickstein L B; Springer T A
Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1.
The Journal of experimental medicine 1993;177(4):1187-92.
1993: Kirchhausen T; Staunton D E; Springer T A
Location of the domains of ICAM-1 by immunolabeling and single-molecule electron microscopy.
Journal of leukocyte biology 1993;53(3):342-6.
1993: Diamond M S; Garcia-Aguilar J; Bickford J K; Corbi A L; Springer T A
The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.
The Journal of cell biology 1993;120(4):1031-43.
1993: Diamond M S; Springer T A
A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.
The Journal of cell biology 1993;120(2):545-56.
1993: Springer T A
Signals on endothelium for lymphocyte recirculation and leukocyte emigration: the area code paradigm.
Harvey lectures 1993;89():53-103.
1992: Xu H; Tong I L; De Fougerolles A R; Springer T A
Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2650-5.
1992: Carpén O; Pallai P; Staunton D E; Springer T A
Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin.
The Journal of cell biology 1992;118(5):1223-34.
1992: Tözeren A; Mackie L H; Lawrence M B; Chan P Y; Dustin M L; Springer T A
Micromanipulation of adhesion of phorbol 12-myristate-13-acetate-stimulated T lymphocytes to planar membranes containing intercellular adhesion molecule-1.
Biophysical journal 1992;63(1):247-58.
1992: Vonderheide R H; Springer T A
Lymphocyte adhesion through very late antigen 4: evidence for a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule 1 and an additional alpha 4 integrin counter-receptor on stimulated endothelium.
The Journal of experimental medicine 1992;175(6):1433-42.
1992: Tözeren A; Sung K L; Sung L A; Dustin M L; Chan P Y; Springer T A; Chien S
Micromanipulation of adhesion of a Jurkat cell to a planar bilayer membrane containing lymphocyte function-associated antigen 3 molecules.
The Journal of cell biology 1992;116(4):997-1006.
1992: Chan P Y; Springer T A
Effect of lengthening lymphocyte function-associated antigen 3 on adhesion to CD2.
Molecular biology of the cell 1992;3(2):157-66.
1992: de Fougerolles A R; Springer T A
Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes.
The Journal of experimental medicine 1992;175(1):185-90.
1991: Springer T A
The next cluster of differentiation (CD) workshop.
Nature 1991;354(6352):415-6.
1991: Carpén O; Dustin M L; Springer T A; Swafford J A; Beckett L A; Caulfield J P
Motility and ultrastructure of large granular lymphocytes on lipid bilayers reconstituted with adhesion receptors LFA-1, ICAM-1, and two isoforms of LFA-3.
The Journal of cell biology 1991;115(3):861-71.
1991: Hibbs M L; Jakes S; Stacker S A; Wallace R W; Springer T A
The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site.
The Journal of experimental medicine 1991;174(5):1227-38.
1991: Chan P Y; Lawrence M B; Dustin M L; Ferguson L M; Golan D E; Springer T A
Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2.
The Journal of cell biology 1991;115(1):245-55.
1991: Kaufmann Y; Tseng E; Springer T A
Cloning of the murine lymphocyte function-associated molecule-1 alpha-subunit and its expression in COS cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(1):369-74.
1991: de Fougerolles A R; Stacker S A; Schwarting R; Springer T A
Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.
The Journal of experimental medicine 1991;174(1):253-67.
1991: Diamond M S; Staunton D E; Marlin S D; Springer T A
Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation.
Cell 1991;65(6):961-71.
1991: Lawrence M B; Springer T A
Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins.
Cell 1991;65(5):859-73.
1991: Hibbs M L; Xu H; Stacker S A; Springer T A
Regulation of adhesion of ICAM-1 by the cytoplasmic domain of LFA-1 integrin beta subunit.
Science (New York, N.Y.) 1991;251(5001):1611-3.
1991: Stacker S A; Springer T A
Leukocyte integrin P150,95 (CD11c/CD18) functions as an adhesion molecule binding to a counter-receptor on stimulated endothelium.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(2):648-55.
1991: Dustin M L; Springer T A
Role of lymphocyte adhesion receptors in transient interactions and cell locomotion.
Annual review of immunology 1991;9():27-66.
1990: Diamond M S; Staunton D E; de Fougerolles A R; Stacker S A; Garcia-Aguilar J; Hibbs M L; Springer T A
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).
The Journal of cell biology 1990;111(6 Pt 2):3129-39.
1990: Springer T A
Adhesion receptors of the immune system.
Nature 1990;346(6283):425-34.
1990: Wardlaw A J; Hibbs M L; Stacker S A; Springer T A
Distinct mutations in two patients with leukocyte adhesion deficiency and their functional correlates.
The Journal of experimental medicine 1990;172(1):335-45.
1990: Larson R S; Springer T A
Structure and function of leukocyte integrins.
Immunological reviews 1990;114():181-217.
1990: Staunton D E; Dustin M L; Erickson H P; Springer T A
The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus.
Cell 1990;61(2):243-54.
1990: Hibbs M L; Wardlaw A J; Stacker S A; Anderson D C; Lee A; Roberts T M; Springer T A
Transfection of cells from patients with leukocyte adhesion deficiency with an integrin beta subunit (CD18) restores lymphocyte function-associated antigen-1 expression and function.
The Journal of clinical investigation 1990;85(3):674-81.
1990: Marlin S D; Staunton D E; Springer T A; Stratowa C; Sommergruber W; Merluzzi V J
A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection.
Nature 1990;344(6261):70-2.
1990: Larson R S; Hibbs M L; Springer T A
The leukocyte integrin LFA-1 reconstituted by cDNA transfection in a nonhematopoietic cell line is functionally active and not transiently regulated.
Cell regulation 1990;1(4):359-67.
1990: Corbi A L; Garcia-Aguilar J; Springer T A
Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule.
The Journal of biological chemistry 1990;265(5):2782-8.
1990: Springer T A
The sensation and regulation of interactions with the extracellular environment: the cell biology of lymphocyte adhesion receptors.
Annual review of cell biology 1990;6():359-402.
1989: Hibbs M L; Selvaraj P; Carpén O; Springer T A; Kuster H; Jouvin M H; Kinet J P
Mechanisms for regulating expression of membrane isoforms of Fc gamma RIII (CD16).
Science (New York, N.Y.) 1989;246(4937):1608-11.
1989: Selvaraj P; Carpén O; Hibbs M L; Springer T A
Natural killer cell and granulocyte Fc gamma receptor III (CD16) differ in membrane anchor and signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3283-8.
1989: Dustin M L; Springer T A
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.
Nature 1989;341(6243):619-24.
1989: Staunton D E; Dustin M L; Springer T A
Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1.
Nature 1989;339(6219):61-4.
1989: Staunton D E; Merluzzi V J; Rothlein R; Barton R; Marlin S D; Springer T A
A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses.
Cell 1989;56(5):849-53.
1989: Larson R S; Corbi A L; Berman L; Springer T
Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.
The Journal of cell biology 1989;108(2):703-12.
1989: Kishimoto T K; O'Conner K; Springer T A
Leukocyte adhesion deficiency. Aberrant splicing of a conserved integrin sequence causes a moderate deficiency phenotype.
The Journal of biological chemistry 1989;264(6):3588-95.
1989: Dustin M L; Olive D; Springer T A
Correlation of CD2 binding and functional properties of multimeric and monomeric lymphocyte function-associated antigen 3.
The Journal of experimental medicine 1989;169(2):503-17.
1989: Hale L P; Martin M E; McCollum D E; Nunley J A; Springer T A; Singer K H; Haynes B F
Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment.
Arthritis and rheumatism 1989;32(1):22-30.
1989: Kishimoto T K; Springer T A
Human leukocyte adhesion deficiency: molecular basis for a defective immune response to infections of the skin.
Current problems in dermatology 1989;18():106-15.
1989: Dustin M L; Garcia-Aguilar J; Hibbs M L; Larson R S; Stacker S A; Staunton D E; Wardlaw A J; Springer T A
Structure and regulation of the leukocyte adhesion receptor LFA-1 and its counterreceptors, ICAM-1 and ICAM-2.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():753-65.
1989: Kishimoto T K; Larson R S; Corbi A L; Dustin M L; Staunton D E; Springer T A
The leukocyte integrins.
Advances in immunology 1989;46():149-82.
1988: Hollander N; Selvaraj P; Springer T A
Biosynthesis and function of LFA-3 in human mutant cells deficient in phosphatidylinositol-anchored proteins.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4283-90.
1988: Denning S M; Dustin M L; Springer T A; Singer K H; Haynes B F
Purified lymphocyte function-associated antigen-3 (LFA-3) activates human thymocytes via the CD2 pathway.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(9):2980-5.
1988: Bockenstedt L K; Goldsmith M A; Dustin M; Olive D; Springer T A; Weiss A
The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(6):1904-11.
1988: Corbi A L; Kishimoto T K; Miller L J; Springer T A
The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.
The Journal of biological chemistry 1988;263(25):12403-11.
1988: Dustin M L; Springer T A
Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.
The Journal of cell biology 1988;107(1):321-31.
1988: Selvaraj P; Rosse W F; Silber R; Springer T A
The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria.
Nature 1988;333(6173):565-7.
1988: Corbi A L; Larson R S; Kishimoto T K; Springer T A; Morton C C
Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion.
The Journal of experimental medicine 1988;167(5):1597-607.
1988: Dustin M L; Singer K H; Tuck D T; Springer T A
Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1).
The Journal of experimental medicine 1988;167(4):1323-40.
1988: Makgoba M W; Sanders M E; Ginther Luce G E; Gugel E A; Dustin M L; Springer T A; Shaw S
Functional evidence that intercellular adhesion molecule-1 (ICAM-1) is a ligand for LFA-1-dependent adhesion in T cell-mediated cytotoxicity.
European journal of immunology 1988;18(4):637-40.
1988: Staunton D E; Marlin S D; Stratowa C; Dustin M L; Springer T A
Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families.
Cell 1988;52(6):925-33.
1988: Cotran R S; Pober J S; Gimbrone M A; Springer T A; Wiebke E A; Gaspari A A; Rosenberg S A; Lotze M T
Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(6):1883-8.
1988: Sanders M E; Makgoba M W; Sharrow S O; Stephany D; Springer T A; Young H A; Shaw S
Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1401-7.
1988: Makgoba M W; Sanders M E; Ginther Luce G E; Dustin M L; Springer T A; Clark E A; Mannoni P; Shaw S
ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells.
Nature 1988;331(6151):86-8.
1987: Corbi A L; Miller L J; O'Connor K; Larson R S; Springer T A
cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.
The EMBO journal 1987;6(13):4023-8.
1987: Marlin S D; Springer T A
Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1).
Cell 1987;51(5):813-9.
1987: Bainton D F; Miller L J; Kishimoto T K; Springer T A
Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils.
The Journal of experimental medicine 1987;166(6):1641-53.
1987: Dustin M L; Selvaraj P; Mattaliano R J; Springer T A
Anchoring mechanisms for LFA-3 cell adhesion glycoprotein at membrane surface.
Nature 1987;329(6142):846-8.
1987: Wallner B P; Frey A Z; Tizard R; Mattaliano R J; Hession C; Sanders M E; Dustin M L; Springer T A
Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein.
The Journal of experimental medicine 1987;166(4):923-32.
1987: Selvaraj P; Dustin M L; Silber R; Low M G; Springer T A
Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor.
The Journal of experimental medicine 1987;166(4):1011-25.
1987: Selvaraj P; Dustin M L; Mitnacht R; Hünig T; Springer T A; Plunkett M L
Rosetting of human T lymphocytes with sheep and human erythrocytes. Comparison of human and sheep ligand binding using purified E receptor.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2690-5.
1987: Denning S M; Tuck D T; Vollger L W; Springer T A; Singer K H; Haynes B F
Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2573-8.
1987: Dustin M L; Sanders M E; Shaw S; Springer T A
Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.
The Journal of experimental medicine 1987;165(3):677-92.
1987: Plunkett M L; Sanders M E; Selvaraj P; Dustin M L; Springer T A
Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3).
The Journal of experimental medicine 1987;165(3):664-76.
1987: Selvaraj P; Plunkett M L; Dustin M; Sanders M E; Shaw S; Springer T A
The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3.
Nature 1987;326(6111):400-3.
1987: Vollger L W; Tuck D T; Springer T A; Haynes B F; Singer K H
Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(2):358-63.
1987: Springer T A; Dustin M L; Kishimoto T K; Marlin S D
The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system.
Annual review of immunology 1987;5():223-52.
1986: Shaw S; Luce G E; Quinones R; Gress R E; Springer T A; Sanders M E
Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones.
Nature 1986;323(6085):262-4.
1986: Rothlein R; Dustin M L; Marlin S D; Springer T A
A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(4):1270-4.

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