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Timothy Springer

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Chafen Lu; Li-Zhi Mi; Thomas Schürpf; Thomas Walz; Timothy A Springer
Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.
Thomas Schürpf; Timothy A Springer; Qiang Chen; Jin-Huan Liu; Rui Wang; Jia-huai Wang
The RGD finger of Del-1 is a unique structural feature critical for integrin binding.
Michael B Doud; Adem C Koksal; Chafen Lu; Li-Zhi Mi; Gaojie Song; Timothy A Springer
Unexpected fold in the circumsporozoite protein target of malaria vaccines.

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All Publications

2012: Chafen Lu; Li-Zhi Mi; Thomas Schürpf; Thomas Walz; Timothy A Springer
Mechanisms for kinase-mediated dimerization of the epidermal growth factor receptor.
The Journal of biological chemistry 2012;287(45):38244-53.
2012: Thomas Schürpf; Timothy A Springer; Qiang Chen; Jin-Huan Liu; Rui Wang; Jia-huai Wang
The RGD finger of Del-1 is a unique structural feature critical for integrin binding.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(8):3412-20.
2012: Michael B Doud; Adem C Koksal; Chafen Lu; Li-Zhi Mi; Gaojie Song; Timothy A Springer
Unexpected fold in the circumsporozoite protein target of malaria vaccines.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(20):7817-22.
2012: Peter T Sage; Tracey E Sciuto; Arlene H Sharpe; Timothy A Springer; Laya M Varghese; Ann M Dvorak; Masataka Kamei; Roberta Martinelli; Christopher V Carman
Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(8):3686-99.
2012: Jieqing Zhu; Jianghai Zhu; Richard Aster; Daniel Bougie; Won-Seok Choi; Marta Filizola; Wenwei Huang; Jihong Li; Joshua G McCoy; Sarasija Naini; Ana Negri; Mark Rasmussen; Min Shen; Timothy A Springer; Craig J Thomas; Barry S Coller
Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.
Science translational medicine 2012;4(125):125ra32.
2011: Gabriele Weitz-Schmidt; Thomas Schürpf; Timothy A Springer
The C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrins.
The Journal of biological chemistry 2011;286(49):42115-22.
2011: Thomas Schürpf; Timothy A Springer
Regulation of integrin affinity on cell surfaces.
The EMBO journal 2011;30(23):4712-27.
2011: Yan-Feng Zhou; Thomas Walz; Edward T Eng; Chafen Lu; Noritaka Nishida; Timothy A Springer
A pH-regulated dimeric bouquet in the structure of von Willebrand factor.
The EMBO journal 2011;30(19):4098-111.
2011: Li-Zhi Mi; Noritaka Nishida; Zongli Li; Chafen Lu; Thomas Walz; Timothy A Springer
Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor.
Nature structural & molecular biology 2011;18(9):984-9.
2010: Chafen Lu; Li-Zhi Mi; Michael Grey; Jieqing Zhu; Elizabeth Graef; Shigeyuki Yokoyama; Timothy A Springer
Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor.
Molecular and cellular biology 2010;30(22):5432-43.
2010: Can Xie; Jianghai Zhu; Xing Chen; Lizhi Mi; Noritaka Nishida; Timothy A Springer
Structure of an integrin with an alphaI domain, complement receptor type 4.
The EMBO journal 2010;29(3):666-79.
2009: Xiaohui Zhang; Kenneth Halvorsen; Cheng-Zhong Zhang; Wesley P Wong; Timothy A Springer
Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor.
Science (New York, N.Y.) 2009;324(5932):1330-4.
2009: Bing-Hao Luo; John Karanicolas; Laura D Harmacek; David Baker; Timothy A Springer
Rationally designed integrin beta3 mutants stabilized in the high affinity conformation.
The Journal of biological chemistry 2009;284(6):3917-24.
2009: Travis T Waldron; Timothy A Springer
Transmission of allostery through the lectin domain in selectin-mediated cell adhesion.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):85-90.
2009: Timothy A Springer
Structural basis for selectin mechanochemistry.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):91-6.
2008: Jianghai Zhu; Bing-Hao Luo; Tsan Xiao; Chengzhong Zhang; Noritaka Nishida; Timothy A Springer
Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Molecular cell 2008;32(6):849-61.
2008: Li-Zhi Mi; Michael Grey; Noritaka Nishida; Thomas Walz; Chafen Lu; Timothy A Springer
Functional and structural stability of the epidermal growth factor receptor in detergent micelles and phospholipid nanodiscs.
Biochemistry 2008;47(39):10314-23.
2008: Timothy A Springer; Jianghai Zhu; Tsan Xiao
Structural basis for distinctive recognition of fibrinogen gammaC peptide by the platelet integrin alphaIIbbeta3.
The Journal of cell biology 2008;182(4):791-800.
2008: Hongmin Zhang; Jose M Casasnovas; Moonsoo Jin; Jin-huan Liu; Carl G Gahmberg; Timothy A Springer; Jia-huai Wang
An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5.
Molecular cell 2008;31(3):432-7.
2007: Thomas Vorup-Jensen; Lianli Chi; Louise C Gjelstrup; Uffe B Jensen; Craig A Jewett; Can Xie; Motomu Shimaoka; Robert J Linhardt; Timothy A Springer
Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparin.
The Journal of biological chemistry 2007;282(42):30869-77.
2007: Jieqing Zhu; Christopher V Carman; Minsoo Kim; Motomu Shimaoka; Timothy A Springer; Bing-Hao Luo
Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.
Blood 2007;110(7):2475-83.
2007: Xuehui Chen; Thomas Doohun Kim; Christopher V Carman; Li-Zhi Mi; Gang Song; Timothy A Springer
Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(39):15358-63.
2007: Roberto Bonasio; Christopher V Carman; Enoch Kim; Peter T Sage; Kerry Routenberg Love; Thorsten R Mempel; Timothy A Springer; Ulrich H von Andrian
Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(37):14753-8.
2007: Thomas Vorup-Jensen; Travis T Waldron; Nathan S Astrof; Motomu Shimaoka; Timothy A Springer
The connection between metal ion affinity and ligand affinity in integrin I domains.
Biochimica et biophysica acta 2007;1774(9):1148-55.
2007: Christopher V Carman; Peter T Sage; Tracey E Sciuto; Miguel A de la Fuente; Raif S Geha; Hans D Ochs; Harold F Dvorak; Ann M Dvorak; Timothy A Springer
Transcellular diapedesis is initiated by invasive podosomes.
Immunity 2007;26(6):784-97.
2007: Jieqing Zhu; Brian Boylan; Bing-Hao Luo; Peter J Newman; Timothy A Springer
Tests of the extension and deadbolt models of integrin activation.
The Journal of biological chemistry 2007;282(16):11914-20.
2007: Bing-Hao Luo; Christopher V Carman; Timothy A Springer
Structural basis of integrin regulation and signaling.
Annual review of immunology 2007;25():619-47.
2006: Noritaka Nishida; Thomas Walz; Timothy A Springer
Structural transitions of complement component C3 and its activation products.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19737-42.
2006: Nathan S Astrof; Azucena Salas; Motomu Shimaoka; JianFeng Chen; Timothy A Springer
Importance of force linkage in mechanochemistry of adhesion receptors.
Biochemistry 2006;45(50):15020-8.
2006: WEI YANG; Christopher V Carman; Minsoo Kim; Azucena Salas; Motomu Shimaoka; Timothy A Springer
A small molecule agonist of an integrin, alphaLbeta2.
The Journal of biological chemistry 2006;281(49):37904-12.
2006: Timothy A Springer
Complement and the multifaceted functions of VWA and integrin I domains.
Structure (London, England : 1993) 2006;14(11):1611-6.
2006: Noritaka Nishida; Can Xie; Motomu Shimaoka; Yifan Cheng; Thomas Walz; Timothy A Springer
Activation of leukocyte beta2 integrins by conversion from bent to extended conformations.
Immunity 2006;25(4):583-94.
2006: Bing-Hao Luo; Timothy A Springer
Integrin structures and conformational signaling.
Current opinion in cell biology 2006;18(5):579-86.
2006: Lili Huang; Motomu Shimaoka; Isaac J Rondon; Illa Roy; Qing Chang; Melody Po; Daniel T Dransfield; Robert C Ladner; Albert S B Edge; Azucena Salas; Clive R Wood; Timothy A Springer; Edward H Cohen
Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1.
Journal of leukocyte biology 2006;80(4):905-14.
2006: Motomu Shimaoka; Minsoo Kim; Edward H Cohen; WEI YANG; Nathan S Astrof; Dan Peer; Azucena Salas; Audrey Ferrand; Timothy A Springer
AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):13991-6.
2006: JianFeng Chen; WEI YANG; Minsoo Kim; Christopher V Carman; Timothy A Springer
Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(35):13062-7.
2006: Uyen T Phan; Travis T Waldron; Timothy A Springer
Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force.
Nature immunology 2006;7(8):883-9.
2006: Azucena Salas; Motomu Shimaoka; Uyen T Phan; Minsoo Kim; Timothy A Springer
Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state.
The Journal of biological chemistry 2006;281(16):10876-82.
2006: Moonsoo Jin; Gang Song; Christopher V Carman; Yong-Sung Kim; Nathan S Astrof; Motomu Shimaoka; Dane K Wittrup; Timothy A Springer
Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5758-63.
2006: Gang Song; Greg A Lazar; Tanja Kortemme; Motomu Shimaoka; John Desjarlais; David Baker; Timothy A Springer
Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion.
The Journal of biological chemistry 2006;281(8):5042-9.
2005: Bing-Hao Luo; Christopher V Carman; Junichi Takagi; Timothy A Springer
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3679-84.
2005: Gang Song; Yuting Yang; Jin-Huan Liu; José M Casasnovas; Motomu Shimaoka; Timothy A Springer; Jia-huai Wang
An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3366-71.
2005: Thomas Vorup-Jensen; Christopher V Carman; Motomu Shimaoka; Peter Schuck; Juraj Svitel; Timothy A Springer
Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1614-9.
2004: JianFeng Chen; Junichi Takagi; Can Xie; Tsan Xiao; Bing-Hao Luo; Timothy A Springer
The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7.
The Journal of biological chemistry 2004;279(53):55556-61.
2004: Minsoo Kim; Christopher V Carman; WEI YANG; Azucena Salas; Timothy A Springer
The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.
The Journal of cell biology 2004;167(6):1241-53.
2004: Moonsoo Jin; Ioan Andricioaei; Timothy A Springer
Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics.
Structure (London, England : 1993) 2004;12(12):2137-47.
2004: Tsan Xiao; Junichi Takagi; Barry S Coller; Jia-huai Wang; Timothy A Springer
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics.
Nature 2004;432(7013):59-67.
2004: Can Xie; Motomu Shimaoka; Tsan Xiao; Pascale Schwab; Lloyd B Klickstein; Timothy A Springer
The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(43):15422-7.
2004: Christopher V Carman; Timothy A Springer
A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them.
The Journal of cell biology 2004;167(2):377-88.
2004: Chafen Lu; Motomu Shimaoka; Azucena Salas; Timothy A Springer
The binding sites for competitive antagonistic, allosteric antagonistic, and agonistic antibodies to the I domain of integrin LFA-1.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3972-8.
2004: Bing-Hao Luo; Konstantin Strokovich; Thomas Walz; Timothy A Springer; Junichi Takagi
Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain.
The Journal of biological chemistry 2004;279(26):27466-71.
2004: Bing-Hao Luo; Timothy A Springer; Junichi Takagi
A specific interface between integrin transmembrane helices and affinity for ligand.
PLoS biology 2004;2(6):e153.
2004: Yuting Yang; Chang-Duk Jun; Jin-Huan Liu; Rongguang Zhang; Andrzej Joachimiak; Timothy A Springer; Jia-huai Wang
Structural basis for dimerization of ICAM-1 on the cell surface.
Molecular cell 2004;14(2):269-76.
2004: Azucena Salas; Motomu Shimaoka; Avi N Kogan; Charlotte Harwood; Ulrich H von Andrian; Timothy A Springer
Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction.
Immunity 2004;20(4):393-406.
2004: Bing-Hao Luo; Junichi Takagi; Timothy A Springer
Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides.
The Journal of biological chemistry 2004;279(11):10215-21.
2004: WEI YANG; Motomu Shimaoka; Azucena Salas; Junichi Takagi; Timothy A Springer
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2906-11.
2004: WEI YANG; Motomu Shimaoka; JianFeng Chen; Timothy A Springer
Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2333-8.
2004: Motomu Shimaoka; Timothy A Springer
Therapeutic antagonists and the conformational regulation of the beta2 integrins.
Current topics in medicinal chemistry 2004;4(14):1485-95.
2004: Timothy A Springer; Jia-huai Wang
The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion.
Advances in protein chemistry 2004;68():29-63.
2003: Christopher V Carman; Chang-Duk Jun; Azucena Salas; Timothy A Springer
Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6135-44.
2003: JianFeng Chen; Azucena Salas; Timothy A Springer
Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster.
Nature structural biology 2003;10(12):995-1001.
2003: Christopher V Carman; Timothy A Springer
Integrin avidity regulation: are changes in affinity and conformation underemphasized?
Current opinion in cell biology 2003;15(5):547-56.
2003: Minsoo Kim; Christopher V Carman; Timothy A Springer
Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins.
Science (New York, N.Y.) 2003;301(5640):1720-5.
2003: Junichi Takagi; Konstantin Strokovich; Timothy A Springer; Thomas Walz
Structure of integrin alpha5beta1 in complex with fibronectin.
The EMBO journal 2003;22(18):4607-15.
2003: Motomu Shimaoka; Azucena Salas; WEI YANG; Gabriele Weitz-Schmidt; Timothy A Springer
Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other.
Immunity 2003;19(3):391-402.
2003: Motomu Shimaoka; Timothy A Springer
Therapeutic antagonists and conformational regulation of integrin function.
Nature reviews. Drug discovery 2003;2(9):703-16.
2003: Bing-Hao Luo; Timothy A Springer; Junichi Takagi
High affinity ligand binding by integrins does not involve head separation.
The Journal of biological chemistry 2003;278(19):17185-9.
2003: Bing-Hao Luo; Timothy A Springer; Junichi Takagi
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2403-8.
2003: Thomas Vorup-Jensen; Christian Ostermeier; Motomu Shimaoka; Ulrich Hommel; Timothy A Springer
Structure and allosteric regulation of the alpha X beta 2 integrin I domain.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1873-8.
2003: Motomu Shimaoka; Tsan Xiao; Jin-Huan Liu; Yuting Yang; Yicheng Dong; Chang-Duk Jun; Alison McCormack; Rongguang Zhang; Andrzej Joachimiak; Junichi Takagi; Jia-huai Wang; Timothy A Springer
Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.
Cell 2003;112(1):99-111.
2002: Azucena Salas; Motomu Shimaoka; Shuqi Chen; Christopher V Carman; Timothy A Springer
Transition from rolling to firm adhesion is regulated by the conformation of the I domain of the integrin lymphocyte function-associated antigen-1.
The Journal of biological chemistry 2002;277(52):50255-62.
2002: Motomu Shimaoka; Chafen Lu; Azucena Salas; Tsan Xiao; Junichi Takagi; Timothy A Springer
Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16737-41.
2002: Timothy A Springer
Predicted and experimental structures of integrins and beta-propellers.
Current opinion in structural biology 2002;12(6):802-13.
2002: Hua Jing; Junichi Takagi; Jin-huan Liu; Sara Lindgren; Rong-guang Zhang; Andrzej Joachimiak; Jia-huai Wang; Timothy A Springer
Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins.
Structure (London, England : 1993) 2002;10(10):1453-64.
2002: Junichi Takagi; Benjamin M Petre; Thomas Walz; Timothy A Springer
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling.
Cell 2002;110(5):599-11.
2002: Junichi Takagi; Timothy A Springer
Integrin activation and structural rearrangement.
Immunological reviews 2002;186():141-63.
2002: Timothy A Springer
César Milstein, the father of modern immunology.
Nature immunology 2002;3(6):501-3.
2002: Timothy A Springer
Immunology. Retrospective: César Milstein (1927-2002).
Science (New York, N.Y.) 2002;296(5571):1253.
2002: Junichi Takagi; Daniel P DeBottis; Harold P Erickson; Timothy A Springer
The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding.
Biochemistry 2002;41(13):4339-47.
2002: Natalia Beglova; Stephen C Blacklow; Junichi Takagi; Timothy A Springer
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.
Nature structural biology 2002;9(4):282-7.
2002: Qing Ma; Motomu Shimaoka; Chafen Lu; Hua Jing; Christopher V Carman; Timothy A Springer
Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1.
The Journal of biological chemistry 2002;277(12):10638-41.
2002: Motomu Shimaoka; Junichi Takagi; Timothy A Springer
Conformational regulation of integrin structure and function.
Annual review of biophysics and biomolecular structure 2002;31():485-516.
2001: M de Château; Selby Chen; Azucena Salas; Timothy A Springer
Kinetic and mechanical basis of rolling through an integrin and novel Ca2+-dependent rolling and Mg2+-dependent firm adhesion modalities for the alpha 4 beta 7-MAdCAM-1 interaction.
Biochemistry 2001;40(46):13972-9.
2001: Junichi Takagi; Natalia Beglova; P Yalamanchili; Stephen C Blacklow; Timothy A Springer
Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11175-80.
2001: N Manjunath; Premlata Shankar; Junmei Wan; Wolfgang Weninger; Maura A Crowley; K Hieshima; Timothy A Springer; X Fan; H Shen; Judy Lieberman; Ulrich H von Andrian
Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes.
The Journal of clinical investigation 2001;108(6):871-8.
2001: Chang-Duk Jun; Christopher V Carman; Sambra D Redick; Motomu Shimaoka; Harold P Erickson; Timothy A Springer
Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1).
The Journal of biological chemistry 2001;276(31):29019-27.
2001: Roger S Smith; ER Fedyk; Timothy A Springer; N Mukaida; Barbara H Iglewski; Richard P Phipps
IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):366-74.
2001: Chang-Duk Jun; Motomu Shimaoka; Christopher V Carman; Junichi Takagi; Timothy A Springer
Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6830-5.
2001: Hyesung Jeon; W Meng; Junichi Takagi; Michael J Eck; Timothy A Springer; Stephen C Blacklow
Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
Nature structural biology 2001;8(6):499-504.
2001: Motomu Shimaoka; Chafen Lu; Roger Palframan; Ulrich H von Andrian; A McCormack; Junichi Takagi; Timothy A Springer
Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6009-14.
2001: Chafen Lu; Junichi Takagi; Timothy A Springer
Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state.
The Journal of biological chemistry 2001;276(18):14642-8.
2001: Timothy A Springer
Immunoaffinity chromatography.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 8():Unit 8.2.
2001: Junichi Takagi; Harold P Erickson; Timothy A Springer
C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1.
Nature structural biology 2001;8(5):412-6.
2001: ER Fedyk; D Jones; Hilary Critchley; Richard P Phipps; Timothy M Blieden; Timothy A Springer
Expression of stromal-derived factor-1 is decreased by IL-1 and TNF and in dermal wound healing.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5749-54.
2001: Chafen Lu; M Ferzly; Junichi Takagi; Timothy A Springer
Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5629-37.
2001: Q Zang; Timothy A Springer
Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2).
The Journal of biological chemistry 2001;276(10):6922-9.
2001: Chafen Lu; Motomu Shimaoka; Q Zang; Junichi Takagi; Timothy A Springer
Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2393-8.
2001: Chafen Lu; Motomu Shimaoka; M Ferzly; C Oxvig; Junichi Takagi; Timothy A Springer
An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2387-92.
2001: Selby Chen; Timothy A Springer
Selectin receptor-ligand bonds: Formation limited by shear rate and dissociation governed by the Bell model.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):950-5.
2000: Motomu Shimaoka; Julia M Shifman; H Jing; Junichi Takagi; Stephen L Mayo; Timothy A Springer
Computational design of an integrin I domain stabilized in the open high affinity conformation.
Nature structural biology 2000;7(8):674-8.
2000: Q Zang; Chafen Lu; Chao Huang; Junichi Takagi; Timothy A Springer
The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3.
The Journal of biological chemistry 2000;275(29):22202-12.
2000: P Yalamanchili; Chafen Lu; C Oxvig; Timothy A Springer
Folding and function of I domain-deleted Mac-1 and lymphocyte function-associated antigen-1.
The Journal of biological chemistry 2000;275(29):21877-82.
2000: Chao Huang; Q Zang; Junichi Takagi; Timothy A Springer
Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain.
The Journal of biological chemistry 2000;275(28):21514-24.
1999: ER Fedyk; D H Ryyan; I Ritterman; Timothy A Springer
Maturation decreases responsiveness of human bone marrow B lineage cells to stromal-derived factor 1 (SDF-1).
Journal of leukocyte biology 1999;66(4):667-73.
1999: Qing Ma; D Jones; Timothy A Springer
The chemokine receptor CXCR4 is required for the retention of B lineage and granulocytic precursors within the bone marrow microenvironment.
Immunity 1999;10(4):463-71.
1999: José M Casasnovas; C Pieroni; Timothy A Springer
Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3017-22.
1999: C Oxvig; Chafen Lu; Timothy A Springer
Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2215-20.
1999: Selby Chen; Timothy A Springer
An automatic braking system that stabilizes leukocyte rolling by an increase in selectin bond number with shear.
The Journal of cell biology 1999;144(1):185-200.
1998: C Weber; Timothy A Springer
Interaction of very late antigen-4 with VCAM-1 supports transendothelial chemotaxis of monocytes by facilitating lateral migration.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6825-34.
1998: Mitsugi Nagashima; T Shin'oka; Georg Nollert; D Shum-Tim; Paul R Hickey; Stephen J Roth; A Kirchhoff; Timothy A Springer; P R Burke; John E Mayer
Effects of a monoclonal antibody to P-selectin on recovery of neonatal lamb hearts after cold cardioplegic ischemia.
Circulation 1998;98(19 Suppl):II391-7; discussion II397-8.
1998: Ronen Alon; Selby Chen; Robert C Fuhlbrigge; KD Puri; Timothy A Springer
The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11631-6.
1998: Qing Ma; D Jones; Paul R Borghesani; Rosalind A Segal; T Nagasawa; T Kishimoto; Roderick T Bronson; Timothy A Springer
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9448-53.
1998: José M Casasnovas; J K Bickford; Timothy A Springer
The domain structure of ICAM-1 and the kinetics of binding to rhinovirus.
Journal of virology 1998;72(7):6244-6.
1998: Kemin Tan; J M Casasnovas; Jin-Huan Liu; M J Briskin; Timothy A Springer; Jia-huai Wang
The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition.
Structure (London, England : 1993) 1998;6(6):793-801.
1998: Chafen Lu; C Oxvig; Timothy A Springer
The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. Dependence on beta subunit association and prediction of domains.
The Journal of biological chemistry 1998;273(24):15138-47.
1998: J Wang; Timothy A Springer
Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses.
Immunological reviews 1998;163():197-215.
1998: J Kitayama; CR Mackay; Paul D Ponath; Timothy A Springer
The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow.
The Journal of clinical investigation 1998;101(9):2017-24.
1998: L Petruzzelli; L Maduzia; Timothy A Springer
Differential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4208-16.
1998: KD Puri; Selby Chen; Timothy A Springer
Modifying the mechanical property and shear threshold of L-selectin adhesion independently of equilibrium properties.
Nature 1998;392(6679):930-3.
1998: C Oxvig; Timothy A Springer
Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):4870-5.
1998: José M Casasnovas; Thilo Stehle; Jin-Huan Liu; Jia-huai Wang; Timothy A Springer
A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4134-9.
1998: CC Bleul; Joachim L Schultze; Timothy A Springer
B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement.
The Journal of experimental medicine 1998;187(5):753-62.
1998: L Piali; C Weber; Greg La Rosa; CR Mackay; Timothy A Springer; Ian Clark-Lewis; Bernhard Moser
The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig.
European journal of immunology 1998;28(3):961-72.
1998: R A Clark; Robert C Fuhlbrigge; Timothy A Springer
L-Selectin ligands that are O-glycoprotease resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endothelial venules.
The Journal of cell biology 1998;140(3):721-31.
1998: Cristina Parolin; Alessandra Borsetti; Hyeryun Choe; Michael Farzan; Peter Kolchinsky; M Heesen; Qui Fu Ma; Craig Gerard; Giorgio Palú; Martin E Dorf; Timothy A Springer; Joseph Sodroski
Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses.
Journal of virology 1998;72(2):1652-6.
1998: Stephen J Roth; T G Diacovo; Michael B Brenner; Jean-Pierre Rosat; J Buccola; Craig Morita; Timothy A Springer
Transendothelial chemotaxis of human alpha/beta and gamma/delta T lymphocytes to chemokines.
European journal of immunology 1998;28(1):104-13.
1997: C Weber; C F Lu; José M Casasnovas; Timothy A Springer
Role of alpha L beta 2 integrin avidity in transendothelial chemotaxis of mononuclear cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):3968-75.
1997: J Kitayama; Robert C Fuhlbrigge; K D Puri; Timothy A Springer
P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):3929-39.
1997: C Weber; Timothy A Springer
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor.
The Journal of clinical investigation 1997;100(8):2085-93.
1997: Ronen Alon; Selby Chen; KD Puri; E B Finger; Timothy A Springer
The kinetics of L-selectin tethers and the mechanics of selectin-mediated rolling.
The Journal of cell biology 1997;138(5):1169-80.
1997: S Tanabe; M Heesen; I Yoshizawa; Michael A Berman; Yi Luo; CC Bleul; Timothy A Springer; K Okuda; N Gerard; Martin E Dorf
Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):905-11.
1997: C F Lu; Timothy A Springer
The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):268-78.
1997: José M Casasnovas; Timothy A Springer; Jin-Huan Liu; Stephen C Harrison; Jia-huai Wang
Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.
Nature 1997;387(6630):312-5.
1997: R A Clark; Harold P Erickson; Timothy A Springer
Tenascin supports lymphocyte rolling.
The Journal of cell biology 1997;137(3):755-65.
1997: Selby Chen; Ronen Alon; Robert C Fuhlbrigge; Timothy A Springer
Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3172-7.
1997: Chao Huang; Timothy A Springer
Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3162-7.
1997: Chao Huang; Chafen Lu; Timothy A Springer
Folding of the conserved domain but not of flanking regions in the integrin beta2 subunit requires association with the alpha subunit.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3156-61.
1997: CC Bleul; L Wu; JA Hoxie; Timothy A Springer; CR Mackay
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1925-30.
1997: J Kitayama; M W Carr; Stephen J Roth; J Buccola; Timothy A Springer
Contrasting responses to multiple chemotactic stimuli in transendothelial migration: heterologous desensitization in neutrophils and augmentation of migration in eosinophils.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2340-9.
1997: Timothy A Springer
Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(1):65-72.
1997: A Aiuti; I J Webb; C Bleul; Timothy A Springer; Jose-Carlos Gutierrez-Ramos
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.
The Journal of experimental medicine 1997;185(1):111-20.
1997: KD Puri; E B Finger; Timothy A Springer
The faster kinetics of L-selectin than of E-selectin and P-selectin rolling at comparable binding strength.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):405-13.
1996: E B Finger; R E Bruehl; DF Bainton; Timothy A Springer
A differential role for cell shape in neutrophil tethering and rolling on endothelial selectins under flow.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5085-96.
1996: Ronen Alon; Robert C Fuhlbrigge; E B Finger; Timothy A Springer
Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow.
The Journal of cell biology 1996;135(3):849-65.
1996: Robert C Fuhlbrigge; Ronen Alon; KD Puri; J B Lowe; Timothy A Springer
Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions.
The Journal of cell biology 1996;135(3):837-48.
1996: C Weber; J Kitayama; Timothy A Springer
Differential regulation of beta 1 and beta 2 integrin avidity by chemoattractants in eosinophils.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(20):10939-44.
1996: Lloyd B Klickstein; M R York; A R Fougerolles; Timothy A Springer
Localization of the binding site on intercellular adhesion molecule-3 (ICAM-3) for lymphocyte function-associated antigen 1 (LFA-1).
The Journal of biological chemistry 1996;271(39):23920-7.
1996: C C Bleul; Robert C Fuhlbrigge; José M Casasnovas; A Aiuti; Timothy A Springer
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
The Journal of experimental medicine 1996;184(3):1101-9.
1996: C C Bleul; Michael Farzan; Hyeryun Choe; Cristina Parolin; I Clark-Lewis; Joseph Sodroski; Timothy A Springer
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.
Nature 1996;382(6594):829-33.
1996: R A Clark; Ronen Alon; Timothy A Springer
CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma.
The Journal of cell biology 1996;134(4):1075-87.
1996: C Weber; Ronen Alon; B Moser; Timothy A Springer
Sequential regulation of alpha 4 beta 1 and alpha 5 beta 1 integrin avidity by CC chemokines in monocytes: implications for transendothelial chemotaxis.
The Journal of cell biology 1996;134(4):1063-73.
1996: R E Bruehl; Timothy A Springer; DF Bainton
Quantitation of L-selectin distribution on human leukocyte microvilli by immunogold labeling and electron microscopy.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1996;44(8):835-44.
1996: T G Diacovo; KD Puri; R A Warnock; Timothy A Springer; Ulrich H von Andrian
Platelet-mediated lymphocyte delivery to high endothelial venules.
Science (New York, N.Y.) 1996;273(5272):252-5.
1996: Charles A Parkos; Sean P Colgan; M S Diamond; Asma Nusrat; Tony Liang; Timothy A Springer; James L Madara
Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: consequences for CD11b/CD18-mediated interactions with neutrophils.
Molecular medicine (Cambridge, Mass.) 1996;2(4):489-505.
1996: T G Diacovo; Stephen J Roth; J M Buccola; DF Bainton; Timothy A Springer
Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18.
Blood 1996;88(1):146-57.
1996: D A Wong; E M Davis; M LeBeau; Timothy A Springer
Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit.
Gene 1996;171(2):291-4.
1996: KD Puri; Timothy A Springer
A schiff base with mildly oxidized carbohydrate ligands stabilizes L-selectin and not P-selectin or E-selectin rolling adhesions in shear flow.
The Journal of biological chemistry 1996;271(10):5404-13.
1996: T G Diacovo; Stephen J Roth; Craig Morita; Jean-Pierre Rosat; Michael B Brenner; Timothy A Springer
Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin.
The Journal of experimental medicine 1996;183(3):1193-203.
1996: J P Girard; Timothy A Springer
Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules.
The Journal of biological chemistry 1996;271(8):4511-7.
1996: Michael L Dustin; L M Ferguson; P Y Chan; Timothy A Springer; David E Golan
Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area.
The Journal of cell biology 1996;132(3):465-74.
1996: M W Carr; Ronen Alon; Timothy A Springer
The C-C chemokine MCP-1 differentially modulates the avidity of beta 1 and beta 2 integrins on T lymphocytes.
Immunity 1996;4(2):179-87.
1996: E B Finger; KD Puri; Ronen Alon; Michael B Lawrence; Ulrich H von Andrian; Timothy A Springer
Adhesion through L-selectin requires a threshold hydrodynamic shear.
Nature 1996;379(6562):266-9.
1995: Stephen J Roth; M W Carr; S S Rose; Timothy A Springer
Characterization of transendothelial chemotaxis of T lymphocytes.
Journal of immunological methods 1995;188(1):97-116.
1995: Stephen J Roth; M W Carr; Timothy A Springer
C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes.
European journal of immunology 1995;25(12):3482-8.
1995: KD Puri; E B Finger; G Gaudernack; Timothy A Springer
Sialomucin CD34 is the major L-selectin ligand in human tonsil high endothelial venules.
The Journal of cell biology 1995;131(1):261-70.
1995: M S Diamond; Ronen Alon; Charles A Parkos; Mark T Quinn; Timothy A Springer
Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1).
The Journal of cell biology 1995;130(6):1473-82.
1995: Chao Huang; Timothy A Springer
A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1).
The Journal of biological chemistry 1995;270(32):19008-16.
1995: L Petruzzelli; L Maduzia; Timothy A Springer
Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(2):854-66.
1995: José M Casasnovas; Timothy A Springer
Kinetics and thermodynamics of virus binding to receptor. Studies with rhinovirus, intercellular adhesion molecule-1 (ICAM-1), and surface plasmon resonance.
The Journal of biological chemistry 1995;270(22):13216-24.
1995: P D Kassner; Ronen Alon; Timothy A Springer; Martin Helmer
Specialized functional properties of the integrin alpha 4 cytoplasmic domain.
Molecular biology of the cell 1995;6(6):661-74.
1995: Ronen Alon; T Feizi; C T Yuen; Robert C Fuhlbrigge; Timothy A Springer
Glycolipid ligands for selectins support leukocyte tethering and rolling under physiologic flow conditions.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(10):5356-66.
1995: Ronen Alon; D A Hammer; Timothy A Springer
Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow.
Nature 1995;374(6522):539-42.
1995: A R de Fougerolles; M S Diamond; Timothy A Springer
Heterogenous glycosylation of ICAM-3 and lack of interaction with Mac-1 and p150,95.
European journal of immunology 1995;25(4):1008-12.
1995: Michael B Lawrence; Ellen L Berg; Eugene C Butcher; Timothy A Springer
Rolling of lymphocytes and neutrophils on peripheral node addressin and subsequent arrest on ICAM-1 in shear flow.
European journal of immunology 1995;25(4):1025-31.
1995: Ronen Alon; P D Kassner; M W Carr; E B Finger; Martin Helmer; Timothy A Springer
The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.
The Journal of cell biology 1995;128(6):1243-53.
1995: Timothy A Springer
Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration.
Annual review of physiology 1995;57():827-72.
1995: J P Girard; Timothy A Springer
Cloning from purified high endothelial venule cells of hevin, a close relative of the antiadhesive extracellular matrix protein SPARC.
Immunity 1995;2(1):113-23.
1995: T Kinashi; Y St Pierre; Timothy A Springer
Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells.
Journal of leukocyte biology 1995;57(1):168-73.
1994: T G Diacovo; A R deFougerolles; DF Bainton; Timothy A Springer
A functional integrin ligand on the surface of platelets: intercellular adhesion molecule-2.
The Journal of clinical investigation 1994;94(3):1243-51.
1994: J M Casasnovas; Timothy A Springer
Pathway of rhinovirus disruption by soluble intercellular adhesion molecule 1 (ICAM-1): an intermediate in which ICAM-1 is bound and RNA is released.
Journal of virology 1994;68(9):5882-9.
1994: H Xu; Jose-Angel Gonzalo; Y St Pierre; Ifor Williams; Thomas S Kupper; R S Cotran; Timothy A Springer; Jose-Carlos Gutierrez-Ramos
Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.
The Journal of experimental medicine 1994;180(1):95-109.
1994: M S Diamond; Timothy A Springer
The dynamic regulation of integrin adhesiveness.
Current biology : CB 1994;4(6):506-17.
1994: Michael B Lawrence; DF Bainton; Timothy A Springer
Neutrophil tethering to and rolling on E-selectin are separable by requirement for L-selectin.
Immunity 1994;1(2):137-45.
1994: C A Bilsland; M S Diamond; Timothy A Springer
The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4582-9.
1994: M W Carr; Stephen J Roth; E Luther; S S Rose; Timothy A Springer
Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3652-6.
1994: C A Bilsland; Timothy A Springer
Cloning and expression of the chicken CD18 cDNA.
Journal of leukocyte biology 1994;55(4):501-6.
1994: R H Vonderheide; Thomas F Tedder; Timothy A Springer; D E Staunton
Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4.
The Journal of cell biology 1994;125(1):215-22.
1994: Stuart F Schlossman; Laurence Boumsell; W Gilks; J M Harlan; T Kishimoto; Chikao Morimoto; Jerome Ritz; S Shaw; R L Silverstein; Timothy A Springer
CD antigens 1993.
Blood 1994;83(4):879-80.
1994: A R de Fougerolles; X Qin; Timothy A Springer
Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses.
The Journal of experimental medicine 1994;179(2):619-29.
1994: Timothy A Springer
Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.
Cell 1994;76(2):301-14.
1994: Stuart F Schlossman; Laurence Boumsell; W Gilks; J M Harlan; T Kishimoto; Chikao Morimoto; Jerome Ritz; S Shaw; R L Silverstein; Timothy A Springer
CD antigens 1993.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(1):1-2.
1994: T Kinashi; Timothy A Springer
Adhesion molecules in hematopoietic cells.
Blood cells 1994;20(1):25-44.
1993: Michael B Lawrence; Timothy A Springer
Neutrophils roll on E-selectin.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6338-46.
1993: S Martin; A Martin; D E Staunton; Timothy A Springer
Functional studies of truncated soluble intercellular adhesion molecule 1 expressed in Escherichia coli.
Antimicrobial agents and chemotherapy 1993;37(6):1278-84.
1993: S Martin; J M Casasnovas; D E Staunton; Timothy A Springer
Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules.
Journal of virology 1993;67(6):3561-8.
1993: A R de Fougerolles; Lloyd B Klickstein; Timothy A Springer
Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1.
The Journal of experimental medicine 1993;177(4):1187-92.
1993: T Kirchhausen; D E Staunton; Timothy A Springer
Location of the domains of ICAM-1 by immunolabeling and single-molecule electron microscopy.
Journal of leukocyte biology 1993;53(3):342-6.
1993: M S Diamond; J Garcia-Aguilar; J K Bickford; A L Corbi; Timothy A Springer
The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.
The Journal of cell biology 1993;120(4):1031-43.
1993: M S Diamond; Timothy A Springer
A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.
The Journal of cell biology 1993;120(2):545-56.
1993: Timothy A Springer
Signals on endothelium for lymphocyte recirculation and leukocyte emigration: the area code paradigm.
Harvey lectures 1993;89():53-103.
1992: H Xu; I L Tong; A R De Fougerolles; Timothy A Springer
Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2650-5.
1992: O Carpén; P Pallai; D E Staunton; Timothy A Springer
Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin.
The Journal of cell biology 1992;118(5):1223-34.
1992: A Tözeren; L H Mackie; M B Lawrence; P Y Chan; Michael L Dustin; Timothy A Springer
Micromanipulation of adhesion of phorbol 12-myristate-13-acetate-stimulated T lymphocytes to planar membranes containing intercellular adhesion molecule-1.
Biophysical journal 1992;63(1):247-58.
1992: R H Vonderheide; Timothy A Springer
Lymphocyte adhesion through very late antigen 4: evidence for a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule 1 and an additional alpha 4 integrin counter-receptor on stimulated endothelium.
The Journal of experimental medicine 1992;175(6):1433-42.
1992: A Tözeren; K L Paul Sung; L A Sung; Michael L Dustin; P Y Chan; Timothy A Springer; Shu Chien
Micromanipulation of adhesion of a Jurkat cell to a planar bilayer membrane containing lymphocyte function-associated antigen 3 molecules.
The Journal of cell biology 1992;116(4):997-1006.
1992: P Y Chan; Timothy A Springer
Effect of lengthening lymphocyte function-associated antigen 3 on adhesion to CD2.
Molecular biology of the cell 1992;3(2):157-66.
1992: A R de Fougerolles; Timothy A Springer
Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes.
The Journal of experimental medicine 1992;175(1):185-90.
1991: Timothy A Springer
The next cluster of differentiation (CD) workshop.
Nature 1991;354(6352):415-6.
1991: O Carpén; Michael L Dustin; Timothy A Springer; J A Swafford; Laurel Beckett; J P Caulfield
Motility and ultrastructure of large granular lymphocytes on lipid bilayers reconstituted with adhesion receptors LFA-1, ICAM-1, and two isoforms of LFA-3.
The Journal of cell biology 1991;115(3):861-71.
1991: Margaret L Hibbs; S Jakes; Steven A Stacker; R W Wallace; Timothy A Springer
The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site.
The Journal of experimental medicine 1991;174(5):1227-38.
1991: P Y Chan; M B Lawrence; Michael L Dustin; L M Ferguson; David E Golan; Timothy A Springer
Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2.
The Journal of cell biology 1991;115(1):245-55.
1991: Y Kaufmann; E Tseng; Timothy A Springer
Cloning of the murine lymphocyte function-associated molecule-1 alpha-subunit and its expression in COS cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(1):369-74.
1991: A R de Fougerolles; Steven A Stacker; R Schwarting; Timothy A Springer
Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.
The Journal of experimental medicine 1991;174(1):253-67.
1991: M S Diamond; D E Staunton; S D Marlin; Timothy A Springer
Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation.
Cell 1991;65(6):961-71.
1991: M B Lawrence; Timothy A Springer
Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins.
Cell 1991;65(5):859-73.
1991: Margaret L Hibbs; H Xu; Steven A Stacker; Timothy A Springer
Regulation of adhesion of ICAM-1 by the cytoplasmic domain of LFA-1 integrin beta subunit.
Science (New York, N.Y.) 1991;251(5001):1611-3.
1991: Steven A Stacker; Timothy A Springer
Leukocyte integrin P150,95 (CD11c/CD18) functions as an adhesion molecule binding to a counter-receptor on stimulated endothelium.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(2):648-55.
1991: Michael L Dustin; Timothy A Springer
Role of lymphocyte adhesion receptors in transient interactions and cell locomotion.
Annual review of immunology 1991;9():27-66.
1990: M S Diamond; D E Staunton; A R de Fougerolles; Steven A Stacker; J Garcia-Aguilar; Margaret L Hibbs; Timothy A Springer
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).
The Journal of cell biology 1990;111(6 Pt 2):3129-39.
1990: Timothy A Springer
Adhesion receptors of the immune system.
Nature 1990;346(6283):425-34.
1990: A J Wardlaw; Margaret L Hibbs; Steven A Stacker; Timothy A Springer
Distinct mutations in two patients with leukocyte adhesion deficiency and their functional correlates.
The Journal of experimental medicine 1990;172(1):335-45.
1990: D E Staunton; Michael L Dustin; H P Erickson; Timothy A Springer
The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus.
Cell 1990;61(2):243-54.
1990: Richard Larson; Timothy A Springer
Structure and function of leukocyte integrins.
Immunological reviews 1990;114():181-217.
1990: Margaret L Hibbs; A J Wardlaw; Steven A Stacker; D C Anderson; A Lee; Thomas M Roberts; Timothy A Springer
Transfection of cells from patients with leukocyte adhesion deficiency with an integrin beta subunit (CD18) restores lymphocyte function-associated antigen-1 expression and function.
The Journal of clinical investigation 1990;85(3):674-81.
1990: S D Marlin; D E Staunton; Timothy A Springer; C Stratowa; W Sommergruber; V J Merluzzi
A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection.
Nature 1990;344(6261):70-2.
1990: Richard Larson; Margaret L Hibbs; Timothy A Springer
The leukocyte integrin LFA-1 reconstituted by cDNA transfection in a nonhematopoietic cell line is functionally active and not transiently regulated.
Cell regulation 1990;1(4):359-67.
1990: A L Corbi; J Garcia-Aguilar; Timothy A Springer
Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule.
The Journal of biological chemistry 1990;265(5):2782-8.
1990: Timothy A Springer
The sensation and regulation of interactions with the extracellular environment: the cell biology of lymphocyte adhesion receptors.
Annual review of cell biology 1990;6():359-402.
1989: Margaret L Hibbs; Periasamy Selvaraj; O Carpén; Timothy A Springer; H Kuster; M H Jouvin; Jean-Pierre Kinet
Mechanisms for regulating expression of membrane isoforms of Fc gamma RIII (CD16).
Science (New York, N.Y.) 1989;246(4937):1608-11.
1989: Periasamy Selvaraj; O Carpén; Margaret L Hibbs; Timothy A Springer
Natural killer cell and granulocyte Fc gamma receptor III (CD16) differ in membrane anchor and signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(10):3283-8.
1989: Michael L Dustin; Timothy A Springer
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.
Nature 1989;341(6243):619-24.
1989: D E Staunton; Michael L Dustin; Timothy A Springer
Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1.
Nature 1989;339(6219):61-4.
1989: D E Staunton; V J Merluzzi; R Rothlein; R Barton; S D Marlin; Timothy A Springer
A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses.
Cell 1989;56(5):849-53.
1989: T K Kishimoto; K O'Conner; Timothy A Springer
Leukocyte adhesion deficiency. Aberrant splicing of a conserved integrin sequence causes a moderate deficiency phenotype.
The Journal of biological chemistry 1989;264(6):3588-95.
1989: Richard Larson; A L Corbi; L Berman; Timothy A Springer
Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.
The Journal of cell biology 1989;108(2):703-12.
1989: Michael L Dustin; D Olive; Timothy A Springer
Correlation of CD2 binding and functional properties of multimeric and monomeric lymphocyte function-associated antigen 3.
The Journal of experimental medicine 1989;169(2):503-17.
1989: T K Kishimoto; Timothy A Springer
Human leukocyte adhesion deficiency: molecular basis for a defective immune response to infections of the skin.
Current problems in dermatology 1989;18():106-15.
1989: Michael L Dustin; J Garcia-Aguilar; Margaret L Hibbs; Richard Larson; Steven A Stacker; D E Staunton; A J Wardlaw; Timothy A Springer
Structure and regulation of the leukocyte adhesion receptor LFA-1 and its counterreceptors, ICAM-1 and ICAM-2.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():753-65.
1989: T K Kishimoto; Richard Larson; A L Corbi; Michael L Dustin; D E Staunton; Timothy A Springer
The leukocyte integrins.
Advances in immunology 1989;46():149-82.
1989: Laura P Hale; M E Martin; D E McCollum; James A Nunley; Timothy A Springer; K H Singer; Barton F Haynes
Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment.
Arthritis and rheumatism 1989;32(1):22-30.
1988: N Hollander; Periasamy Selvaraj; Timothy A Springer
Biosynthesis and function of LFA-3 in human mutant cells deficient in phosphatidylinositol-anchored proteins.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(12):4283-90.
1988: S M Denning; Michael L Dustin; Timothy A Springer; K H Singer; Barton F Haynes
Purified lymphocyte function-associated antigen-3 (LFA-3) activates human thymocytes via the CD2 pathway.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(9):2980-5.
1988: Linda K Bockenstedt; Mark A Goldsmith; M Dustin; D Olive; Timothy A Springer; Arthur Weiss
The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(6):1904-11.
1988: A L Corbi; T K Kishimoto; Linda Miller; Timothy A Springer
The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.
The Journal of biological chemistry 1988;263(25):12403-11.
1988: Michael L Dustin; Timothy A Springer
Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.
The Journal of cell biology 1988;107(1):321-31.
1988: Periasamy Selvaraj; W F Rosse; R Silber; Timothy A Springer
The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria.
Nature 1988;333(6173):565-7.
1988: A L Corbi; Richard Larson; T K Kishimoto; Timothy A Springer; C C Morton
Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion.
The Journal of experimental medicine 1988;167(5):1597-607.
1988: Michael L Dustin; K H Singer; D T Tuck; Timothy A Springer
Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1).
The Journal of experimental medicine 1988;167(4):1323-40.
1988: M W Makgoba; M E Sanders; G E Ginther Luce; E A Gugel; Michael L Dustin; Timothy A Springer; S Shaw
Functional evidence that intercellular adhesion molecule-1 (ICAM-1) is a ligand for LFA-1-dependent adhesion in T cell-mediated cytotoxicity.
European journal of immunology 1988;18(4):637-40.
1988: D E Staunton; S D Marlin; C Stratowa; Michael L Dustin; Timothy A Springer
Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families.
Cell 1988;52(6):925-33.
1988: RS Cotran; J S Pober; Michael A Gimbrone; Timothy A Springer; E A Wiebke; Anthony Gaspari; STEVEN ROSENBERG; M T Lotze
Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(6):1883-8.
1988: M E Sanders; M W Makgoba; Susan O Sharrow; D Stephany; Timothy A Springer; H A Young; S Shaw
Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1401-7.
1988: M W Makgoba; M E Sanders; G E Ginther Luce; Michael L Dustin; Timothy A Springer; E A Clark; P Mannoni; S Shaw
ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells.
Nature 1988;331(6151):86-8.
1987: A L Corbi; Linda Miller; K O'Connor; Richard Larson; Timothy A Springer
cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.
The EMBO journal 1987;6(13):4023-8.
1987: S D Marlin; Timothy A Springer
Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1).
Cell 1987;51(5):813-9.
1987: DF Bainton; Linda Miller; T K Kishimoto; Timothy A Springer
Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils.
The Journal of experimental medicine 1987;166(6):1641-53.
1987: Michael L Dustin; Periasamy Selvaraj; R J Mattaliano; Timothy A Springer
Anchoring mechanisms for LFA-3 cell adhesion glycoprotein at membrane surface.
Nature 1987;329(6142):846-8.
1987: Periasamy Selvaraj; Michael L Dustin; R Mitnacht; Thomas Hünig; Timothy A Springer; M L Plunkett
Rosetting of human T lymphocytes with sheep and human erythrocytes. Comparison of human and sheep ligand binding using purified E receptor.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2690-5.
1987: S M Denning; D T Tuck; L W Vollger; Timothy A Springer; K H Singer; Barton F Haynes
Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(8):2573-8.
1987: B P Wallner; A Z Frey; R Tizard; R J Mattaliano; Cathy Hession; M E Sanders; Michael L Dustin; Timothy A Springer
Primary structure of lymphocyte function-associated antigen 3 (LFA-3). The ligand of the T lymphocyte CD2 glycoprotein.
The Journal of experimental medicine 1987;166(4):923-32.
1987: Periasamy Selvaraj; Michael L Dustin; R Silber; M G Low; Timothy A Springer
Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor.
The Journal of experimental medicine 1987;166(4):1011-25.
1987: Periasamy Selvaraj; M L Plunkett; Michael L Dustin; M E Sanders; S Shaw; Timothy A Springer
The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3.
Nature 1987;326(6111):400-3.
1987: Michael L Dustin; M E Sanders; S Shaw; Timothy A Springer
Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion.
The Journal of experimental medicine 1987;165(3):677-92.
1987: M L Plunkett; M E Sanders; Periasamy Selvaraj; Michael L Dustin; Timothy A Springer
Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3).
The Journal of experimental medicine 1987;165(3):664-76.
1987: L W Vollger; D T Tuck; Timothy A Springer; Barton F Haynes; K H Singer
Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(2):358-63.
1987: Timothy A Springer; Michael L Dustin; T K Kishimoto; S D Marlin
The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system.
Annual review of immunology 1987;5():223-52.
1986: S Shaw; G E Luce; R Quinones; Ronald E Gress; Timothy A Springer; M E Sanders
Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones.
Nature 1986;323(6085):262-4.
1986: Robert Rothlein; Michael L Dustin; S D Marlin; Timothy A Springer
A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(4):1270-4.