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Spotswood Spruance

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Sherman G Sorensen; Spotswood L Spruance; Randall Smout; Susan Horn
Transcranial Doppler quantification of residual shunt after percutaneous patent foramen ovale closure: correlation of device efficacy with intracardiac anatomic measures.
Sherman G Sorensen; Randall Smout; Spotswood L Spruance
Transcranial doppler quantification of residual shunt after percutaneous patent foramen ovale closure: efficacy of the GORE(®) HELEX septal occluder.
Christopher M Hull; Johan Harmenberg; Eva Arlander; Fred Aoki; Johan Bring; Börje Darpö; Myron J Levin; Stephen Tyring; Spotswood L Spruance
Early treatment of cold sores with topical ME-609 decreases the frequency of ulcerative lesions: a randomized, double-blind, placebo-controlled, patient-initiated clinical trial.

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All Publications

2012: Sherman G Sorensen; Spotswood L Spruance; Randall Smout; Susan Horn
Transcranial Doppler quantification of residual shunt after percutaneous patent foramen ovale closure: correlation of device efficacy with intracardiac anatomic measures.
Journal of interventional cardiology 2012;25(3):304-12.
2011: Sherman G Sorensen; Randall Smout; Spotswood L Spruance
Transcranial doppler quantification of residual shunt after percutaneous patent foramen ovale closure: efficacy of the GORE(®) HELEX septal occluder.
Journal of interventional cardiology 2011;24(4):366-72.
2011: Christopher M Hull; Johan Harmenberg; Eva Arlander; Fred Aoki; Johan Bring; Börje Darpö; Myron J Levin; Stephen Tyring; Spotswood L Spruance
Early treatment of cold sores with topical ME-609 decreases the frequency of ulcerative lesions: a randomized, double-blind, placebo-controlled, patient-initiated clinical trial.
Journal of the American Academy of Dermatology 2011;64(4):696.e1-11.
2009: Christopher M Hull; M McKeough; K Sebastian; J Kriesel; Spotswood L Spruance
Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient-initiated, double-blind, placebo-controlled pilot trial.
Journal of the European Academy of Dermatology and Venereology : JEADV 2009;23(3):263-7.
2007: Christopher M Hull; Spotswood L Spruance
Situational antiviral drug prophylaxis for HSV type 1 recurrences.
Herpes : the journal of the IHMF 2007;14(2):37-40.
2007: Stanley Gilbert; Lawrence Corey; Anthony Cunningham; Jean-Elie Malkin; Lawrence R Stanberry; Richard Whitley; Spotswood L Spruance
An update on short-course intermittent and prevention therapies for herpes labialis.
Herpes : the journal of the IHMF 2007;14 Suppl 1():13A-18A.
2007: Spotswood L Spruance; Fred Y Aoki; Stephen Tyring; Lawrence R Stanberry; Richard Whitley; Kamal Hamed
Short-course therapy for recurrent genital herpes and herpes labialis.
The Journal of family practice 2007;56(1):30-6.
2006: Christopher M Hull; Spotswood L Spruance; Stephen Tyring; Kamal Hamed
Single-dose famciclovir for the treatment of herpes labialis.
Current medical research and opinion 2006;22(9):1699-702.
2006: Eric M Morrel; Spotswood L Spruance; Dennis I Goldberg
Topical iontophoretic administration of acyclovir for the episodic treatment of herpes labialis: a randomized, double-blind, placebo-controlled, clinic-initiated trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;43(4):460-7.
2006: Spotswood L Spruance; Neil Bodsworth; Harvey Resnick; Marcus Conant; Claude Oeuvray; Joseph Gao; Kamal Hamed
Single-dose, patient-initiated famciclovir: a randomized, double-blind, placebo-controlled trial for episodic treatment of herpes labialis.
Journal of the American Academy of Dermatology 2006;55(1):47-53.
2005: David I Bernstein; Spotswood L Spruance; Sujata S Arora; Jennifer L Schroeder; Tze-Chiang Meng
Evaluation of imiquimod 5% cream to modify the natural history of herpes labialis: a pilot study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2005;41(6):808-14.
2005: John D Kriesel; Spotswood L Spruance; Mark Prichard; Jacqueline N Parker; Earl R Kern
Recurrent antiviral-resistant genital herpes in an immunocompetent patient.
The Journal of infectious diseases 2005;192(1):156-61.
2004: SL Sacks; PD Griffiths; Lawrence Corey; C Cohen; Anthony Cunningham; GM Dusheiko; S Self; Spotswood L Spruance; Lawrence R Stanberry; Anna Wald; RJ Whitley
HSV-2 transmission.
Antiviral research 2004;63 Suppl 1():S27-35.
2004: SL Sacks; PD Griffiths; Lawrence Corey; C Cohen; Anthony Cunningham; GM Dusheiko; S Self; Spotswood L Spruance; Lawrence R Stanberry; Anna Wald; RJ Whitley
HSV shedding.
Antiviral research 2004;63 Suppl 1():S19-26.
2004: SL Sacks; PD Griffiths; Lawrence Corey; C Cohen; Anthony Cunningham; GM Dusheiko; S Self; Spotswood L Spruance; Lawrence R Stanberry; Anna Wald; RJ Whitley
Lessons from HIV and hepatitis viruses.
Antiviral research 2004;63 Suppl 1():S11-8.
2004: SL Sacks; PD Griffiths; Lawrence Corey; C Cohen; Anthony Cunningham; GM Dusheiko; S Self; Spotswood L Spruance; Lawrence R Stanberry; Anna Wald; RJ Whitley
Introduction: Is viral shedding a surrogate marker for transmission of genital herpes?
Antiviral research 2004;63 Suppl 1():S3-9.
2004: Spotswood L Spruance; Julia E Reid; Michael Grace; Matthew H Samore
Hazard ratio in clinical trials.
Antimicrobial agents and chemotherapy 2004;48(8):2787-92.
2004: Spotswood L Spruance; Joanne Hill
Clinical significance of antiviral therapy for episodic treatment of herpes labialis: exploratory analyses of the combined data from two valaciclovir trials.
The Journal of antimicrobial chemotherapy 2004;53(5):703-7.
2004: John D Kriesel; Andrea White; Frederick G Hayden; Spotswood L Spruance; Jack H Petajan
Multiple sclerosis attacks are associated with picornavirus infections.
Multiple sclerosis (Houndmills, Basingstoke, England) 2004;10(2):145-8.
2004: John D Kriesel; Brandt B Jones; Kimberly M Dahms; Spotswood L Spruance
STAT1 binds to the herpes simplex virus type 1 latency-associated transcript promoter.
Journal of neurovirology 2004;10(1):12-20.
2003: Young Kyoo Shin; Adriana Weinberg; Spotswood L Spruance; Mariann Bernard; Teresa H Bacon; Ron J Boon; Myron J Levin
Susceptibility of herpes simplex virus isolates to nucleoside analogues and the proportion of nucleoside-resistant variants after repeated topical application of penciclovir to recurrent herpes labialis.
The Journal of infectious diseases 2003;187(8):1241-5.
2003: Spotswood L Spruance; Terry M Jones; Mark M Blatter; Mauricio Vargas-Cortes; Judy Barber; Joanne Hill; Donna Goldstein; Margaret Schultz
High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies.
Antimicrobial agents and chemotherapy 2003;47(3):1072-80.
2002: Spotswood L Spruance; John D Kriesel
Treatment of herpes simplex labialis.
Herpes : the journal of the IHMF 2002;9(3):64-9.
2002: Lawrence R Stanberry; Spotswood L Spruance; Anthony L Cunningham; David I Bernstein; Adrian Mindel; Stephen Sacks; Stephen Tyring; Fred Y Aoki; Moncef Slaoui; Martine Denis; Pierre Vandepapeliere; Gary Dubin
Glycoprotein-D-adjuvant vaccine to prevent genital herpes.
The New England journal of medicine 2002;347(21):1652-61.
2002: Spotswood L Spruance
N-docosanol (Abreva) for herpes labialis: problems and questions.
Journal of the American Academy of Dermatology 2002;47(3):457-8.
2002: Spotswood L Spruance; Robert Nett; Thomas C Marbury; Ray Wolff; James Johnson; Theodore Spaulding
Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials.
Antimicrobial agents and chemotherapy 2002;46(7):2238-43.
2002: T G Evans; D I Bernstein; G Wayne Raborn; J Harmenberg; J Kowalski; Spotswood L Spruance
Double-blind, randomized, placebo-controlled study of topical 5% acyclovir-1% hydrocortisone cream (ME-609) for treatment of UV radiation-induced herpes labialis.
Antimicrobial agents and chemotherapy 2002;46(6):1870-4.
2002: G Wayne Raborn; Alain Y Martel; Michel Lassonde; M A O Lewis; Ron J Boon; Spotswood L Spruance
Effective treatment of herpes simplex labialis with penciclovir cream: combined results of two trials.
Journal of the American Dental Association (1939) 2002;133(3):303-9.
2001: M B McKeough; Spotswood L Spruance
Comparison of new topical treatments for herpes labialis: efficacy of penciclovir cream, acyclovir cream, and n-docosanol cream against experimental cutaneous herpes simplex virus type 1 infection.
Archives of dermatology 2001;137(9):1153-8.
2001: Spotswood L Spruance; Stephen Tyring; M H Smith; Tze-Chiang Meng
Application of a topical immune response modifier, resiquimod gel, to modify the recurrence rate of recurrent genital herpes: a pilot study.
The Journal of infectious diseases 2001;184(2):196-200.
2001: John D Kriesel; B B Jones; IP Hwang; K M Dahms; Spotswood L Spruance
Signal transducers and activators of transcription (Stat) are detectable in mouse trigeminal ganglion neurons.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001;21(6):445-50.
2000: Spotswood L Spruance; M B McKeough
Combination treatment with famciclovir and a topical corticosteroid gel versus famciclovir alone for experimental ultraviolet radiation-induced herpes simplex labialis: a pilot study.
The Journal of infectious diseases 2000;181(6):1906-10.
2000: Lawrence R Stanberry; A L Cunningham; Adrian Mindel; L L Scott; Spotswood L Spruance; Fred Y Aoki; Charles J N Lacey
Prospects for control of herpes simplex virus disease through immunization.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2000;30(3):549-66.
1999: Spotswood L Spruance; N H Rowe; G Wayne Raborn; EA Thibodeau; J A D'Ambrosio; D I Bernstein
Peroral famciclovir in the treatment of experimental ultraviolet radiation-induced herpes simplex labialis: A double-blind, dose-ranging, placebo-controlled, multicenter trial.
The Journal of infectious diseases 1999;179(2):303-10.
1998: John Ioannidis; A C Collier; D A Cooper; L Corey; A P Fiddian; B G Gazzard; P D Griffiths; D G Contopoulos-Ioannidis; J Lau; Andrew T Pavia; M S Saag; Spotswood L Spruance; M S Youle
Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data.
The Journal of infectious diseases 1998;178(2):349-59.
1998: Karl R Beutner; Stephen Tyring; K F Trofatter; John M Douglas; Spotswood L Spruance; Mary L Owens; Terry L Fox; AJ Hougham; K A Schmitt
Imiquimod, a patient-applied immune-response modifier for treatment of external genital warts.
Antimicrobial agents and chemotherapy 1998;42(4):789-94.
1998: Stephen Tyring; John M Douglas; L Corey; Spotswood L Spruance; J Esmann
A randomized, placebo-controlled comparison of oral valacyclovir and acyclovir in immunocompetent patients with recurrent genital herpes infections. The Valaciclovir International Study Group.
Archives of dermatology 1998;134(2):185-91.
1998: Karl R Beutner; Spotswood L Spruance; AJ Hougham; Terry L Fox; Mary L Owens; John M Douglas
Treatment of genital warts with an immune-response modifier (imiquimod).
Journal of the American Academy of Dermatology 1998;38(2 Pt 1):230-9.
1997: John D Kriesel; J Ricigliano; Spotswood L Spruance; H H Garza; J M Hill
Neuronal reactivation of herpes simplex virus may involve interleukin-6.
Journal of neurovirology 1997;3(6):441-8.
1997: David I Bernstein; Charles Schleupner; T G Evans; Dean Blumberg; Yvonne Bryson; K Grafford; P Broberg; S Martin-Munley; Spotswood L Spruance
Effect of foscarnet cream on experimental UV radiation-induced herpes labialis.
Antimicrobial agents and chemotherapy 1997;41(9):1961-4.
1997: Spotswood L Spruance; T L Rea; C Thoming; R Tucker; Robin Saltzman; Ron J Boon
Penciclovir cream for the treatment of herpes simplex labialis. A randomized, multicenter, double-blind, placebo-controlled trial. Topical Penciclovir Collaborative Study Group.
JAMA : the journal of the American Medical Association 1997;277(17):1374-9.
1997: John D Kriesel; B M Gebhardt; J M Hill; Sarah A Maulden; IP Hwang; Thomas E Clinch; X Cao; Spotswood L Spruance; BA Araneo
Anti-interleukin-6 antibodies inhibit herpes simplex virus reactivation.
The Journal of infectious diseases 1997;175(4):821-7.
1997: Spotswood L Spruance; Andrew T Pavia; J W Mellors; R Murphy; Joseph C Gathe; E Stool; J G Jemsek; P Dellamonica; Anne Cross; LM Dunkle
Clinical efficacy of monotherapy with stavudine compared with zidovudine in HIV-infected, zidovudine-experienced patients. A randomized, double-blind, controlled trial. Bristol-Myers Squibb Stavudine/019 Study Group.
Annals of internal medicine 1997;126(5):355-63.
1996: John D Kriesel; Spotswood L Spruance; Raymond A Daynes; B A Araneo
Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease.
The Journal of infectious diseases 1996;173(3):536-41.
1995: Spotswood L Spruance; John D Kriesel; T G Evans; M B McKeough
Susceptibility to herpes labialis following multiple experimental exposures to ultraviolet radiation.
Antiviral research 1995;28(1):57-67.
1995: Spotswood L Spruance; T G Evans; M B McKeough; L Thai; B A Araneo; Raymond A Daynes; E M Mishkin; A S Abramovitz
Th1/Th2-like immunity and resistance to herpes simplex labialis.
Antiviral research 1995;28(1):39-55.
1994: John D Kriesel; P L Pisani; M B McKeough; J R Baringer; Spotswood L Spruance
Correlation between detection of herpes simplex virus in oral secretions by PCR and susceptibility to experimental UV radiation-induced herpes labialis.
Journal of clinical microbiology 1994;32(12):3088-90.
1994: John D Kriesel; B Araneo; J P Petajan; Spotswood L Spruance; S Stromatt
Herpes labialis associated with recombinant human ciliary neurotrophic factor.
The Journal of infectious diseases 1994;170(4):1046.
1994: Spotswood L Spruance; Andrew T Pavia; D Peterson; A Berry; Richard B Pollard; Thomas Patterson; I Frank; S C Remick; M Thompson; Rodger D MacArthur; G E Morey; C H Ramirez-Ronda; B M Bernstein; D E Sweet; Lawrence R Crane; E A Peterson; C T Pachucki; S L Green; J Brand; A Rios; LM Dunkle; Anne Cross; M J Brown; P Ingraham; R Gugliotti; A H Schindzielorz; L Smaldone
Didanosine compared with continuation of zidovudine in HIV-infected patients with signs of clinical deterioration while receiving zidovudine. A randomized, double-blind clinical trial. The Bristol-Myers Squibb AI454-010 Study Group.
Annals of internal medicine 1994;120(5):360-8.
1993: TM Rallis; John D Kriesel; John Dumler; L E Wagoner; E D Wright; Spotswood L Spruance
Rocky Mountain spotted fever following cardiac transplantation.
The Western journal of medicine 1993;158(6):625-8.
1993: Spotswood L Spruance
Prophylactic chemotherapy with acyclovir for recurrent herpes simplex labialis.
Journal of medical virology 1993;Suppl 1():27-32.
1992: Spotswood L Spruance
The natural history of recurrent oral-facial herpes simplex virus infection.
Seminars in dermatology 1992;11(3):200-6.
1992: A Wayne Meikle; R W Dorchuck; B A Araneo; J D Stringham; T G Evans; Spotswood L Spruance; Raymond A Daynes
The presence of a dehydroepiandrosterone-specific receptor binding complex in murine T cells.
The Journal of steroid biochemistry and molecular biology 1992;42(3-4):293-304.
1991: Spotswood L Spruance; D J Freeman; J C Stewart; M B McKeough; L G Wenerstrom; Gerald G Krueger; M W Piepkorn; W G Stroop; N H Rowe
The natural history of ultraviolet radiation-induced herpes simplex labialis and response to therapy with peroral and topical formulations of acyclovir.
The Journal of infectious diseases 1991;163(4):728-34.
1990: Spotswood L Spruance; D J Freeman
Topical treatment of cutaneous herpes simplex virus infections.
Antiviral research 1990;14(6):305-21.
1990: W S Updike; C J Anderson; M S Lundberg; Spotswood L Spruance
Successful medical treatment of listerial brain abscess.
The Western journal of medicine 1990;152(3):298-301.
1990: Spotswood L Spruance; J C Stewart; D J Freeman; V J Brightman; J L Cox; G Wenerstrom; M B McKeough; N H Rowe
Early application of topical 15% idoxuridine in dimethyl sulfoxide shortens the course of herpes simplex labialis: a multicenter placebo-controlled trial.
The Journal of infectious diseases 1990;161(2):191-7.
1990: Spotswood L Spruance; J C Stewart; N H Rowe; M B McKeough; G Wenerstrom; D J Freeman
Treatment of recurrent herpes simplex labialis with oral acyclovir.
The Journal of infectious diseases 1990;161(2):185-90.
1989: H H Shirley; M K Lundergan; H James Williams; Spotswood L Spruance
Lack of ocular changes with dimethyl sulfoxide therapy of scleroderma.
Pharmacotherapy 1989;9(3):165-8.
1988: Spotswood L Spruance; M L Hamill; W S Hoge; L G Davis; J Mills
Acyclovir prevents reactivation of herpes simplex labialis in skiers.
JAMA : the journal of the American Medical Association 1988;260(11):1597-9.
1988: Spotswood L Spruance
Cutaneous herpes simplex virus lesions induced by ultraviolet radiation. A review of model systems and prophylactic therapy with oral acyclovir.
The American journal of medicine 1988;85(2A):43-5.
1988: Spotswood L Spruance; M B McKeough
Evaluation of antiviral treatments for recurrent herpes simplex labialis in the dorsal cutaneous guinea pig model.
Antiviral research 1988;9(5):295-313.
1988: Laurence J Meyer; P de Miranda; N Sheth; Spotswood L Spruance
Acyclovir in human breast milk.
American journal of obstetrics and gynecology 1988;158(3 Pt 1):586-8.
1987: N V Sheth; M B McKeough; Spotswood L Spruance
Measurement of the stratum corneum drug reservoir to predict the therapeutic efficacy of topical iododeoxyuridine for herpes simplex virus infection.
The Journal of investigative dermatology 1987;89(6):598-602.
1987: D J Freeman; M B McKeough; Spotswood L Spruance
Recombinant human interferon-alpha A treatment of an experimental cutaneous herpes simplex virus type 1 infection of guinea pigs.
Journal of interferon research 1987;7(2):213-22.
1986: Spotswood L Spruance; D J Freeman; N V Sheth
Comparison of foscarnet cream, acyclovir cream, and acyclovir ointment in the topical treatment of experimental cutaneous herpes simplex virus type 1 infection.
Antimicrobial agents and chemotherapy 1986;30(1):196-8.
1986: D J Freeman; N V Sheth; Spotswood L Spruance
Failure of topical acyclovir in ointment to penetrate human skin.
Antimicrobial agents and chemotherapy 1986;29(5):730-2.
1985: Spotswood L Spruance; D J Freeman; N V Sheth
Comparison of topically applied 5-ethyl-2'-deoxyuridine and acyclovir in the treatment of cutaneous herpes simplex virus infection in guinea pigs.
Antimicrobial agents and chemotherapy 1985;28(1):103-6.
1985: J A Green; P N Weiss; T J Yeh; Spotswood L Spruance
Immune-specific interferon production by peripheral blood mononuclear leukocytes from patients with primary and recurrent oro-labial herpes simplex virus infections.
Journal of medical virology 1985;16(3):297-305.
1985: D J Freeman; G Wenerstrom; Spotswood L Spruance
Treatment of recurrent herpes simplex labialis with topical butylated hydroxytoluene.
Clinical pharmacology and therapeutics 1985;38(1):56-9.
1985: J A Green; Spotswood L Spruance; G Wenerstrom; M W Piepkorn
Post-herpetic erythema multiforme prevented with prophylactic oral acyclovir.
Annals of internal medicine 1985;102(5):632-3.
1985: John A Bosso; Spotswood L Spruance; G Wenerstrom
Tolerance and percutaneous absorption of topically applied arildone.
Journal of clinical pharmacology 1985;25(2):95-9.
1984: Spotswood L Spruance; G Wenerstrom
Pathogenesis of recurrent herpes simplex labialis. IV. Maturation of lesions within 8 hours after onset and implications for antiviral treatment.
Oral surgery, oral medicine, and oral pathology 1984;58(6):667-71.
1984: Spotswood L Spruance; C S Crumpacker; L E Schnipper; E R Kern; S Marlowe; K A Arndt; J C Overall
Early, patient-initiated treatment of herpes labialis with topical 10% acyclovir.
Antimicrobial agents and chemotherapy 1984;25(5):553-5.
1984: Spotswood L Spruance; M B McKeough; J R Cardinal
Penetration of guinea pig skin by acyclovir in different vehicles and correlation with the efficacy of topical therapy of experimental cutaneous herpes simplex virus infection.
Antimicrobial agents and chemotherapy 1984;25(1):10-5.
1983: J A Green; P N Weiss; Spotswood L Spruance
Spontaneous and induced interferon production by peripheral blood mononuclear leukocytes from humans with herpes labialis.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(6):2827-9.
1983: Spotswood L Spruance; M B McKeough; J R Cardinal
Dimethyl sulfoxide as a vehicle for topical antiviral chemotherapy.
Annals of the New York Academy of Sciences 1983;411():28-33.
1982: Spotswood L Spruance; L E Schnipper; J C Overall; E R Kern; B Wester; J Modlin; G Wenerstrom; C Burton; K A Arndt; G L Chiu; C S Crumpacker
Treatment of herpes simplex labialis with topical acyclovir in polyethylene glycol.
The Journal of infectious diseases 1982;146(1):85-90.
1982: Spotswood L Spruance; J A Green; G Chiu; T J Yeh; G Wenerstrom; J C Overall
Pathogenesis of herpes simplex labialis: correlation of vesicle fluid interferon with lesion age and virus titer.
Infection and immunity 1982;36(3):907-10.
1981: J C Huff; G G Krueger; J C Overall; J Copeland; Spotswood L Spruance
The histopathologic evolution of recurrent herpes simplex labialis.
Journal of the American Academy of Dermatology 1981;5(5):550-7.
1981: J C Overall; Spotswood L Spruance; J A Green
Viral-induced leukocyte interferon in vesicle fluid from lesions of recurrent herpes labialis.
The Journal of infectious diseases 1981;143(4):543-7.
1981: M E Guinan; J MacCalman; E R Kern; J C Overall; Spotswood L Spruance
The course of untreated recurrent genital herpes simplex infection in 27 women.
The New England journal of medicine 1981;304(13):759-63.
1980: M E Guinan; J MacCalman; E R Kern; J C Overall; Spotswood L Spruance
Topical ether and herpes simplex labialis.
JAMA : the journal of the American Medical Association 1980;243(10):1059-61.