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Giannis Spyrou

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Christophoros G Thomas; Giannis Spyrou
ERdj5 sensitizes neuroblastoma cells to endoplasmic reticulum stress-induced apoptosis.
Jie Zhou; Chantzoura Eleni; Giannis Spyrou; Bernhard Brüne
The mitochondrial thioredoxin system regulates nitric oxide-induced HIF-1alpha protein.
Anastasios E Damdimopoulos; Giannis Spyrou; Jan-�ke GUSTAFSSON
Ligands differentially modify the nuclear mobility of estrogen receptors alpha and beta.

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All Publications

2009: Christophoros G Thomas; Giannis Spyrou
ERdj5 sensitizes neuroblastoma cells to endoplasmic reticulum stress-induced apoptosis.
The Journal of biological chemistry 2009;284(10):6282-90.
2008: Jie Zhou; Chantzoura Eleni; Giannis Spyrou; Bernhard Brüne
The mitochondrial thioredoxin system regulates nitric oxide-induced HIF-1alpha protein.
Free radical biology & medicine 2008;44(1):91-8.
2008: Anastasios E Damdimopoulos; Giannis Spyrou; Jan-�ke GUSTAFSSON
Ligands differentially modify the nuclear mobility of estrogen receptors alpha and beta.
Endocrinology 2008;149(1):339-45.
2007: Jolanta Sroka; Agata Antosik; Jaroslaw Czyz; Ivan Nalvarte; Jerker M Olsson; Giannis Spyrou; Zbigniew Madeja
Overexpression of thioredoxin reductase 1 inhibits migration of HEK-293 cells.
Biology of the cell / under the auspices of the European Cell Biology Organization 2007;99(12):677-87.
2007: Anastasios E Damdimopoulos; Jan-�ke GUSTAFSSON; Giannis Spyrou
Nuclear immobilization of DsRed1 tagged proteins: a novel tool for studying DNA-protein interactions?
Biochimica et biophysica acta 2007;1773(6):687-90.
2007: Jie Zhou; Anastasios E Damdimopoulos; Giannis Spyrou; Bernhard Brüne
Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha.
The Journal of biological chemistry 2007;282(10):7482-90.
2007: P Cunnea; A P Fernandes; A Capitanio; S Eken; Giannis Spyrou; Mikael Björnstedt
Increased expression of specific thioredoxin family proteins; a pilot immunohistochemical study on human hepatocellular carcinoma.
International journal of immunopathology and pharmacology 2007;20(1):17-24.
2005: Zbigniew Madeja; Jolanta Sroka; Christina Nyström; Linda Björkhem-Bergman; Tomas Nordman; Anastasios E Damdimopoulos; Ivan Nalvarte; Lennart C Eriksson; Giannis Spyrou; Jerker M Olsson; Mikael Björnstedt
The role of thioredoxin reductase activity in selenium-induced cytotoxicity.
Biochemical pharmacology 2005;69(12):1765-72.
2004: Ivan Nalvarte; Anastasios E Damdimopoulos; Christina Nystöm; Tomas Nordman; Antonio Miranda-Vizuete; Jerker M Olsson; Lennart Eriksson; Mikael Björnstedt; Elias Arnér; Giannis Spyrou
Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation.
The Journal of biological chemistry 2004;279(52):54510-7.
2004: Serguei A Stroev; Tatjana S Gluschenko; Ekaterina I Tjulkova; Giannis Spyrou; Elena Rybnikova; Michail O Samoilov; Markku Pelto-Huikko
Preconditioning enhances the expression of mitochondrial antioxidant thioredoxin-2 in the forebrain of rats exposed to severe hypobaric hypoxia.
Journal of neuroscience research 2004;78(4):563-9.
2004: Anastasios E Damdimopoulos; Antonio Miranda-Vizuete; Eckardt Treuter; Jan-�ke GUSTAFSSON; Giannis Spyrou
An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling.
The Journal of biological chemistry 2004;279(37):38721-9.
2004: Ivan Nalvarte; Anastasios E Damdimopoulos; Giannis Spyrou
Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition.
Free radical biology & medicine 2004;36(10):1270-8.
2003: Christine Sadek; Alberto Jiménez; Anastasios E Damdimopoulos; Thomas Kieselbach; Magnus Nord; Jan-�ke GUSTAFSSON; Giannis Spyrou; Elaine C Davis; Richard Oko; Frans A van Der Hoorn; Antonio Miranda-Vizuete
Characterization of human thioredoxin-like 2. A novel microtubule-binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme.
The Journal of biological chemistry 2003;278(15):13133-42.
2003: Ling Xia; Tomas Nordman; Jerker M Olsson; Anastasios E Damdimopoulos; Linda Björkhem-Bergman; Ivan Nalvarte; Lennart C Eriksson; Elias Arnér; Giannis Spyrou; Mikael Björnstedt
The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress.
The Journal of biological chemistry 2003;278(4):2141-6.
2003: Paula M Cunnea; Antonio Miranda-Vizuete; Gloria Bertoli; Thomas Simmen; Anastasios E Damdimopoulos; Stefan Hermann; Saku Leinonen; Markku Pelto Huikko; Jan-�ke GUSTAFSSON; Roberto Sitia; Giannis Spyrou
ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.
The Journal of biological chemistry 2003;278(2):1059-66.
2003: Tomas Nordman; Ling Xia; Linda Björkhem-Bergman; Anastasios E Damdimopoulos; Ivan Nalvarte; Elias Arnér; Giannis Spyrou; Lennart C Eriksson; Mikael Björnstedt; Jerker M Olsson
Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase.
BioFactors (Oxford, England) 2003;18(1-4):45-50.
2002: Michail O Samoilov; Elena Rybnikova; Ekaterina I Tjulkova; Giannis Spyrou; Markku Pelto-Huikko
The mitochondrial antioxidants thioredoxin-2 and Mn-superoxide dismutase are involved in the mechanisms of brain hypoxic tolerance.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from Russian 2002;387():498-500.
2002: Anastasios E Damdimopoulos; Antonio Miranda-Vizuete; Markku Pelto-Huikko; Jan-�ke GUSTAFSSON; Giannis Spyrou
Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death.
The Journal of biological chemistry 2002;277(36):33249-57.
2002: Alberto Jiménez; Richard Oko; Jan-�ke GUSTAFSSON; Giannis Spyrou; Markku Pelto-Huikko; Antonio Miranda-Vizuete
Cloning, expression and characterization of mouse spermatid specific thioredoxin-1 gene and protein.
Molecular human reproduction 2002;8(8):710-8.
2002: Antonio Miranda-Vizuete; Giannis Spyrou
Genomic organization and identification of a novel alternative splicing variant of mouse mitochondrial thioredoxin reductase (TrxR2) gene.
Molecules and cells 2002;13(3):488-92.
2002: Toru Tanaka; Fumihito Hosoi; Yuko Yamaguchi-Iwai; Md. Kaimul Ahsan; Hiroshi Masutani; Shugo Ueda; Akira Nishiyama; Shunichi Takeda; Hiromi Wada; Giannis Spyrou; Junji Yodoi
Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis.
The EMBO journal 2002;21(7):1695-703.
2001: Christine Sadek; Anastasios E Damdimopoulos; Markku Pelto-Huikko; Jan-�ke GUSTAFSSON; Giannis Spyrou; Antonio Miranda-Vizuete
Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells.
Genes to cells : devoted to molecular & cellular mechanisms 2001;6(12):1077-90.
2001: Elias Arnér; H Nakamura; Tetsuro Sasada; Junji Yodoi; Arne Holmgren; Giannis Spyrou
Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex.
Free radical biology & medicine 2001;31(10):1170-8.
2001: Giannis Spyrou; W Wilson; C Alicia Padilla; Arne Holmgren; Antonio Miranda-Vizuete
A genome-wide survey of human thioredoxin and glutaredoxin family pseudogenes.
Human genetics 2001;109(4):429-39.
2001: Antonio Miranda-Vizuete; J Ljung; Anastasios E Damdimopoulos; Jan-�ke GUSTAFSSON; Richard Oko; Markku Pelto-Huikko; Giannis Spyrou
Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa.
The Journal of biological chemistry 2001;276(34):31567-74.
2001: Antonio Miranda-Vizuete; Giannis Spyrou
Identification of the first human glutaredoxin pseudogene localized to human chromosome 20q11.2.
DNA sequence : the journal of DNA sequencing and mapping 2001;11(6):535-9.
2000: José R Pedrajas; Antonio Miranda-Vizuete; N Javanmardy; Jan-�ke GUSTAFSSON; Giannis Spyrou
Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity.
The Journal of biological chemistry 2000;275(21):16296-301.
2000: Elena Rybnikova; Anastasios E Damdimopoulos; Jan-�ke GUSTAFSSON; Giannis Spyrou; Markku Pelto-Huikko
Expression of novel antioxidant thioredoxin-2 in the rat brain.
The European journal of neuroscience 2000;12(5):1669-78.
2000: Antonio Miranda-Vizuete; Anastasios E Damdimopoulos; Giannis Spyrou
The mitochondrial thioredoxin system.
Antioxidants & redox signaling 2000;2(4):801-10.
2000: Antonio Miranda-Vizuete; Giannis Spyrou
Genomic structure and chromosomal localization of human thioredoxin-like protein gene (txl).
DNA sequence : the journal of DNA sequencing and mapping 2000;10(6):419-24.
2000: Antonio Miranda-Vizuete; Giannis Spyrou
Identification of a novel thioredoxin-1 pseudogene on human chromosome 10.
DNA sequence : the journal of DNA sequencing and mapping 2000;10(6):411-4.
1999: Antonio Miranda-Vizuete; Anastasios E Damdimopoulos; Giannis Spyrou
cDNA cloning, expression and chromosomal localization of the mouse mitochondrial thioredoxin reductase gene(1).
Biochimica et biophysica acta 1999;1447(1):113-8.
1999: Tetsuro Sasada; Md. Kaimul Ahsan; Shugo Ueda; N Sato; Y Kitaoka; Yasuhiro Gon; Arimichi Takabayashi; Giannis Spyrou; Arne Holmgren; Junji Yodoi
Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II).
Free radical biology & medicine 1999;27(5-6):504-14.
1999: Antonio Miranda-Vizuete; Anastasios E Damdimopoulos; José R Pedrajas; Jan-�ke GUSTAFSSON; Giannis Spyrou
Human mitochondrial thioredoxin reductase cDNA cloning, expression and genomic organization.
European journal of biochemistry / FEBS 1999;261(2):405-12.
1999: Eckardt Treuter; Lotta Johansson; Jane S Thomsen; Anette Wärnmark; Jörg Leers; Markku Pelto-Huikko; Mathilda Sjöberg; Anthony P H Wright; Giannis Spyrou; Jan-�ke GUSTAFSSON
Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors. Implications for the recruitment of TRAP and p160 coactivator complexes.
The Journal of biological chemistry 1999;274(10):6667-77.
1999: José R Pedrajas; E Kosmidou; Antonio Miranda-Vizuete; Jan-�ke GUSTAFSSON; Anthony P H Wright; Giannis Spyrou
Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae.
The Journal of biological chemistry 1999;274(10):6366-73.
1999: Antonio Miranda-Vizuete; José R Pedrajas; Anastasios E Damdimopoulos; Giannis Spyrou
Cloning and sequencing of mouse glutaredoxin (grx) cDNA.
DNA sequence : the journal of DNA sequencing and mapping 1999;10(3):179-82.
1999: Lotta Johansson; Jane S Thomsen; Anastasios E Damdimopoulos; Giannis Spyrou; Jan-�ke GUSTAFSSON; Eckardt Treuter
The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta.
The Journal of biological chemistry 1999;274(1):345-53.
1998: Ake Rökaeus; K Jiang; Giannis Spyrou; James A Waschek
Transcriptional control of the galanin gene. Tissue-specific expression and induction by NGF, protein kinase C, and estrogen.
Annals of the New York Academy of Sciences 1998;863():1-13.
1998: K Jiang; Giannis Spyrou; Ake Rökaeus
Characterization of phorbolester-inducible human neuronal factors involved in trans-activation of the galanin gene.
Biochemical and biophysical research communications 1998;246(1):192-8.
1998: Antonio Miranda-Vizuete; Jan-�ke GUSTAFSSON; Giannis Spyrou
Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein.
Biochemical and biophysical research communications 1998;243(1):284-8.
1998: D Nikitovic; Arne Holmgren; Giannis Spyrou
Inhibition of AP-1 DNA binding by nitric oxide involving conserved cysteine residues in Jun and Fos.
Biochemical and biophysical research communications 1998;242(1):109-12.
1997: Antonio Miranda-Vizuete; Anastasios E Damdimopoulos; J Gustafsson; Giannis Spyrou
Cloning, expression, and characterization of a novel Escherichia coli thioredoxin.
The Journal of biological chemistry 1997;272(49):30841-7.
1997: Mikael Björnstedt; S Kumar; L Björkhem; Giannis Spyrou; Arne Holmgren
Selenium and the thioredoxin and glutaredoxin systems.
Biomedical and environmental sciences : BES 1997;10(2-3):271-9.
1997: Antonio Miranda-Vizuete; Giannis Spyrou
The novel oxidoreductase KDRF (KM-102-derived reductase-like factor) is identical with human thioredoxin reductase.
The Biochemical journal 1997;325 ( Pt 1)():287-8.
1997: Alexios Vlamis-Gardikas; F Aslund; Giannis Spyrou; T Bergman; Arne Holmgren
Cloning, overexpression, and characterization of glutaredoxin 2, an atypical glutaredoxin from Escherichia coli.
The Journal of biological chemistry 1997;272(17):11236-43.
1997: Giannis Spyrou; Eva Enmark; Antonio Miranda-Vizuete; J Gustafsson
Cloning and expression of a novel mammalian thioredoxin.
The Journal of biological chemistry 1997;272(5):2936-41.
1996: Giannis Spyrou; M Björnstedt; S Skog; Arne Holmgren
Selenite and selenate inhibit human lymphocyte growth via different mechanisms.
Cancer research 1996;56(19):4407-12.
1996: M Andersson; Arne Holmgren; Giannis Spyrou
NK-lysin, a disulfide-containing effector peptide of T-lymphocytes, is reduced and inactivated by human thioredoxin reductase. Implication for a protective mechanism against NK-lysin cytotoxicity.
The Journal of biological chemistry 1996;271(17):10116-20.
1996: Giannis Spyrou; Arne Holmgren
Deoxyribonucleoside triphosphate pools and growth of glutathione-depleted 3T6 mouse fibroblasts.
Biochemical and biophysical research communications 1996;220(1):42-6.
1996: C A Padilla; Giannis Spyrou; Arne Holmgren
High-level expression of fully active human glutaredoxin (thioltransferase) in E. coli and characterization of Cys7 to Ser mutant protein.
FEBS letters 1996;378(1):69-73.
1995: Giannis Spyrou; M Björnstedt; S Kumar; Arne Holmgren
AP-1 DNA-binding activity is inhibited by selenite and selenodiglutathione.
FEBS letters 1995;368(1):59-63.
1995: C A Padilla; E Martínez-Galisteo; J Antonio Bárcena; Giannis Spyrou; Arne Holmgren
Purification from placenta, amino acid sequence, structure comparisons and cDNA cloning of human glutaredoxin.
European journal of biochemistry / FEBS 1995;227(1-2):27-34.