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Vilhelm Bohr

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Peter Sykora; Takashi Tadokoro; Jingyan Tian; Lior Weissman; David M Wilson; Jenq-Lin Yang; Leslie K Ferrarelli; Guido Keijzers; Avanti Kulkarni; Mark P Mattson; Vilhelm A Bohr
Modulation of DNA base excision repair during neuronal differentiation.
Mette Soerensen; Tinna Stevnsner; H Eka D Suchiman; Qihua Tan; Mikael Thinggaard; James W Vaupel; Rudi G J Westendorp; Marian Beekman; Vilhelm A Bohr; Kaare Christensen; Serena Dato; Anton J M de Craen; Rune Jacobsen; Rabea Kleindorp; Matt McGue; Almut Nebel; Stefan Schreiber; P Eline Slagboom; Lene Christiansen
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.
Morten Scheibye-Knudsen; Chandrika Canugovi; Deborah L Croteau; Karsten Scheibye-Alsing; Vilhelm A Bohr
A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging.

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2013: Peter Sykora; Takashi Tadokoro; Jingyan Tian; Lior Weissman; David M Wilson; Jenq-Lin Yang; Leslie K Ferrarelli; Guido Keijzers; Avanti Kulkarni; Mark P Mattson; Vilhelm A Bohr
Modulation of DNA base excision repair during neuronal differentiation.
Neurobiology of aging 2013;34(7):1717-27.
2013: Mette Soerensen; Tinna Stevnsner; H Eka D Suchiman; Qihua Tan; Mikael Thinggaard; James W Vaupel; Rudi G J Westendorp; Marian Beekman; Vilhelm A Bohr; Kaare Christensen; Serena Dato; Anton J M de Craen; Rune Jacobsen; Rabea Kleindorp; Matt McGue; Almut Nebel; Stefan Schreiber; P Eline Slagboom; Lene Christiansen
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.
Age (Dordrecht, Netherlands) 2013;35(2):487-500.
2013: Morten Scheibye-Knudsen; Chandrika Canugovi; Deborah L Croteau; Karsten Scheibye-Alsing; Vilhelm A Bohr
A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging.
Aging 2013;5(3):192-208.
2013: Christian Garm; Maria Moreno-Villanueva; Inge Petersen; Vilhelm A Bohr; Alexander Bürkle; Kaare Christensen; Tinna Stevnsner
Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells.
Aging cell 2013;12(1):58-66.
2013: Giang Huong Nguyen; Andrew S Rosenthal; Masaaki Sakurai; Pavel Savitsky; Lena Schultz; Anton Simeonov; Dharmendra Kumar Singh; Ajit Jadhav; David J Maloney; Peter J McHugh; Georgina Mosedale; Mika Abu; Csanád Z Bachrati; Vilhelm A Bohr; Wai Kit Chu; Thomas S Dexheimer; Opher Gileadi; Curtis C Harris; Ian D Hickson
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Chemistry & biology 2013;20(1):55-62.
2013: Oliver Popp; Sebastian Veith; Vilhelm A Bohr; Alexander Bürkle; Jörg Fahrer; Aswin Mangerich
Site-specific noncovalent interaction of the biopolymer poly(ADP-ribose) with the Werner syndrome protein regulates protein functions.
ACS chemical biology 2013;8(1):179-88.
2013: Venkateswarlu Popuri; Mahesh Ramamoorthy; Takashi Tadokoro; Deborah L Croteau; Jing Huang; Vilhelm A Bohr
RECQL5 plays co-operative and complementary roles with WRN syndrome helicase.
Nucleic acids research 2013;41(2):881-99.
2012: Deborah L Croteau; Leslie Hoh Ferrarelli; Huiming Lu; Dharmendra Kumar Singh; Vilhelm A Bohr
RECQL4 in genomic instability and aging.
Trends in genetics : TIG 2012;28(12):624-31.
2012: Venkateswarlu Popuri; Robert M Brosh; Deborah L Croteau; Vilhelm A Bohr
RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures.
Cell cycle (Georgetown, Tex.) 2012;11(22):4252-65.
2012: Martin Borch Jensen; Guido Keijzers; Tomasz Kulikowicz; Lene Juel Rasmussen; Deborah L Croteau; Christopher A Dunn; Vilhelm A Bohr
The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients.
Aging 2012;4(11):790-802.
2012: Takashi Tadokoro; Jingyan Tian; David M Wilson; Deborah L Croteau; Alfred May; Venkateswarlu Popuri; Mahesh Ramamoorthy; Ivana Rybanska; Peter Sykora; Vilhelm A Bohr
Human RECQL5 participates in the removal of endogenous DNA damage.
Molecular biology of the cell 2012;23(21):4273-85.
2012: Deborah L Croteau; Lale Dawut; Christopher Dunn; Tomasz Kulikowicz; Jennifer Ross; Marie L Rossi; Vilhelm A Bohr
RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity.
Biochimica et biophysica acta 2012;1822(11):1727-34.
2012: Mahesh Ramamoorthy; Morten Scheibye-Knudsen; Peter Sykora; Yongqing Zhang; Kevin G Becker; Deborah L Croteau; Christopher Dunn; Cindy Kasmer; Vilhelm A Bohr
Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype.
Free radical biology & medicine 2012;53(6):1371-80.
2012: Chandrika Canugovi; Deborah L Croteau; Neil H Feldman; Mark P Mattson; Jeong Seon Yoon; Vilhelm A Bohr
Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(37):14948-53.
2012: Radhakrishnan Kanagaraj; Christiane König; Boris Mihaljevic; Prasanna Parasuraman; Barbara van Loon; Vilhelm A Bohr; Kamila Burdova; Antonia Furrer; Ulrich Hübscher; Pavel Janscak
Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage.
Nucleic acids research 2012;40(17):8449-59.
2012: Brian R Berquist; Chandrika Canugovi; Peter Sykora; David M Wilson; Vilhelm A Bohr
Human Cockayne syndrome B protein reciprocally communicates with mitochondrial proteins and promotes transcriptional elongation.
Nucleic acids research 2012;40(17):8392-405.
2012: Aswin Mangerich; Rita Martello; Oliver Popp; Sebastian Veith; Vilhelm A Bohr; Jörg Fahrer; Alexander Bürkle
Quantitative analysis of WRN exonuclease activity by isotope dilution mass spectrometry.
Mechanisms of ageing and development 2012;133(8):575-9.
2012: Dharmendra Kumar Singh; Deborah L Croteau; Avik K Ghosh; Pavel Janscak; Tomasz Kulikowicz; Venkateswarlu Popuri; Mahesh Ramamoorthy; Marie L Rossi; Igor Shevelev; Vilhelm A Bohr
The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability.
Nucleic acids research 2012;40(14):6632-48.
2012: Dharmendra Kumar Singh; Deborah L Croteau; Avik K Ghosh; Vilhelm A Bohr
RecQ helicases in DNA double strand break repair and telomere maintenance.
Mutation research 2012;736(1-2):15-24.
2012: Venkateswarlu Popuri; Mahesh Ramamoorthy; Dharmendra Kumar Singh; Takashi Tadokoro; Deborah L Croteau; parimal karmakar; Vilhelm A Bohr
Recruitment and retention dynamics of RECQL5 at DNA double strand break sites.
DNA repair 2012;11(7):624-35.
2012: Takashi Tadokoro; Deborah L Croteau; Lale Dawut; Tomasz Kulikowicz; Vilhelm A Bohr
DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities.
Aging 2012;4(6):417-29.
2012: Deborah L Croteau; Rajesh Kasiviswanathan; Mahesh Ramamoorthy; Marie L Rossi; Dharmendra Kumar Singh; Peter Sykora; Jane Tian; Zheng Ming Wang; Mansour Akbari; Chandrika Canugovi; William C Copeland; Vilhelm A Bohr
RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity.
Aging cell 2012;11(3):456-66.
2012: Mette Soerensen; Tinna Stevnsner; H Eka D Suchiman; Qihua Tan; Mikael Thinggaard; James W Vaupel; Rudi G J Westendorp; Marian Beekman; Vilhelm A Bohr; Kaare Christensen; Serena Dato; Anton J M de Craen; Rune Jacobsen; Rabea Kleindorp; Matt McGue; Almut Nebel; Stefan Schreiber; P Eline Slagboom; Lene Christiansen
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
Experimental gerontology 2012;47(5):379-87.
2012: Morten Scheibye-Knudsen; RICHARD SPENCER; Peter Sykora; David M Wilson; Marcus Cooper; Deborah L Croteau; Rafael de Cabo; Ping-Chang Lin; Scott Maynard; Robin K Minor; Mahesh Ramamoorthy; Vilhelm A Bohr
Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy.
The Journal of experimental medicine 2012;209(4):855-69.
2012: Peter Sykora; David M Wilson; Vilhelm A Bohr
Repair of persistent strand breaks in the mitochondrial genome.
Mechanisms of ageing and development 2012;133(4):169-75.
2012: Mette Soerensen; Tinna Stevnsner; Qihua Tan; Mikael Thinggaard; Karen Andersen-Ranberg; Abraham Aviv; Vilhelm A Bohr; Kaare Christensen; Serena Dato; Jacob v B Hjelmborg; Masayuki Kimura; Marianne Nygaard; Lene Christiansen
Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.
Aging cell 2012;11(2):223-7.
2012: Ricardo Gredilla; Lior Weissman; Jenq-Lin Yang; Vilhelm A Bohr; Tinna Stevnsner
Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease.
Neurobiology of aging 2012;33(4):694-707.
2012: Sofie Dabros Andersen; Vilhelm A Bohr; Yuhong Du; Mahmoud el-Shemerly; Kim Engels; Stefano Ferrari; Haian Fu; Guido Keijzers; Patricia Luhn; Alfred May; Omid Niazi; Emmanouil Rampakakis; Maria Zannis-Hadjopoulos; Lene Juel Rasmussen
14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.
DNA repair 2012;11(3):267-77.
2012: Mahesh Ramamoorthy; Ivana Rybanska; Peter Sykora; Takashi Tadokoro; Robert Wersto; Deborah L Croteau; Avik K Ghosh; Tomasz Kulikowicz; Alfred May; Vilhelm A Bohr
RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression.
Nucleic acids research 2012;40(4):1621-35.
2012: Shepherd H Schurman; Michael M Seidman; Binbing Yu; Deborah L Croteau; Christopher A Dunn; Luigi Ferrucci; Rebecca Greaves; Vilhelm A Bohr
Age-related disease association of endogenous γ-H2AX foci in mononuclear cells derived from leukapheresis.
PloS one 2012;7(9):e45728.
2012: Vilhelm A Bohr
DNA repair: front and center and not going away!
Methods in molecular biology (Clifton, N.J.) 2012;920():1-6.
2012: Fred E Indig; parimal karmakar; Ivana Rybanska; France Carrier; Chakravarty Devulapalli; Haiqing Fu; Vilhelm A Bohr
Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase.
PloS one 2012;7(6):e35229.
2012: Seetha Balasingham; Vilhelm A Bohr; Håvard Homberset; Jon K Laerdahl; Marie L Rossi; Ephrem Debebe Zegeye; Tone Tønjum
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB.
PloS one 2012;7(5):e36960.
2011: Susanne T Venø; Tomasz Kulikowicz; Cezar Pestana; Piotr P Stepien; Tinna Stevnsner; Vilhelm A Bohr
The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus.
The Biochemical journal 2011;440(2):293-300.
2011: Lene Juel Rasmussen; Miriam Sander; Ulla M Wewer; Vilhelm A Bohr
Aging, longevity and health.
Mechanisms of ageing and development 2011;132(10):522-32.
2011: Byungchan Ahn; Vilhelm A Bohr
DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease.
Biochemical and biophysical research communications 2011;411(4):684-9.
2011: Keith W Caldecott; Vilhelm A Bohr; Peter J McKinnon
3rd International Genome Dynamics in Neuroscience Conference: "DNA repair and neurological disease".
Mechanisms of ageing and development 2011;132(8-9):353-4.
2011: Jenq-Lin Yang; Mark P Mattson; Peter Sykora; David M Wilson; Vilhelm A Bohr
The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency.
Mechanisms of ageing and development 2011;132(8-9):405-11.
2011: Dennis Kjølhede Jeppesen; Vilhelm A Bohr; Tinna Stevnsner
DNA repair deficiency in neurodegeneration.
Progress in neurobiology 2011;94(2):166-200.
2011: Michel Bernier; Rajib K Paul; Alejandro Martin-Montalvo; Morten Scheibye-Knudsen; Shaoming Song; Hua-Jun He; Sean M Armour; Basil P Hubbard; Vilhelm A Bohr; Lili Wang; Yaping Zong; David A Sinclair; Rafael de Cabo
Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein.
The Journal of biological chemistry 2011;286(22):19270-9.
2011: Laura J Niedernhofer; Miriam Sander; Vilhelm A Bohr; Kenneth H Kraemer
Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: molecules to patients.
Mechanisms of ageing and development 2011;132(6-7):340-7.
2011: Peter Sykora; Deborah L Croteau; Vilhelm A Bohr; David M Wilson
Aprataxin localizes to mitochondria and preserves mitochondrial function.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(18):7437-42.
2011: Albino Bacolla; Guliang Wang; Aklank Jain; Nadia A Chuzhanova; Regina Z Cer; Jack R Collins; David N Cooper; Vilhelm A Bohr; Karen M Vasquez
Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells.
The Journal of biological chemistry 2011;286(12):10017-26.
2011: Sophie Lachapelle; Jean-Philippe Gagné; Chantal Garand; Myriam Desbiens; Yan Coulombe; Vilhelm A Bohr; Michael J Hendzel; Jean-Yves Masson; Guy G Poirier; Michel Lebel
Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples.
Journal of proteome research 2011;10(3):1216-27.
2011: Dong Liu; Deborah L Croteau; Nadja C Souza-Pinto; Michael Pitta; Jingyan Tian; Christopher Wu; Haiyang Jiang; Khadija Mustafa; Guido Keijzers; Vilhelm A Bohr; Mark P Mattson
Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(2):680-92.
2011: Sascha E Liberti; Sofie D Andersen; Jing Wang; Alfred May; Simona Miron; Mylene Perderiset; Guido Keijzers; Omid Niazi; Jean-Baptiste Charbonnier; Vilhelm A Bohr; Lene Juel Rasmussen
Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks.
DNA repair 2011;10(1):73-86.
2011: David B Rhee; Avik Ghosh; Jian Lu; Vilhelm A Bohr; Yie Liu
Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1.
DNA repair 2011;10(1):34-44.
2011: Michel Lebel; Nadja C de Souza-Pinto; Vilhelm A Bohr
Metabolism, genomics, and DNA repair in the mouse aging liver.
Current gerontology and geriatrics research 2011;2011():859415.
2010: Bensu Karahalil; Vilhelm A Bohr; Nadja C de Souza-Pinto
Base excision repair activities differ in human lung cancer cells and corresponding normal controls.
Anticancer research 2010;30(12):4963-71.
2010: Mette Soerensen; Serena Dato; Kaare Christensen; Matt McGue; Tinna Stevnsner; Vilhelm A Bohr; Lene Christiansen
Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data.
Aging cell 2010;9(6):1010-7.
2010: Deborah L Croteau; Nadja C de Souza-Pinto; Charlotte Harboe; Guido Keijzers; Yongqing Zhang; Kevin Becker; Shan Sheng; Vilhelm A Bohr
DNA repair and the accumulation of oxidatively damaged DNA are affected by fruit intake in mice.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(12):1300-11.
2010: Yanrong Su; Jarah A Meador; Gloria M Calaf; Luca Proietti De-Santis; Yongliang Zhao; Vilhelm A Bohr; Adayabalam S Balajee
Human RecQL4 helicase plays critical roles in prostate carcinogenesis.
Cancer research 2010;70(22):9207-17.
2010: Chandrika Canugovi; Scott Maynard; Anne-Cécile V Bayne; Peter Sykora; Jingyan Tian; Nadja C de Souza-Pinto; Deborah L Croteau; Vilhelm A Bohr
The mitochondrial transcription factor A functions in mitochondrial base excision repair.
DNA repair 2010;9(10):1080-9.
2010: Vilhelm A Bohr
[Telomeres--the beginning and the end].
Ugeskrift for laeger 2010;172(40):2744.
2010: Jenq-Lin Yang; Takashi Tadokoro; Guido Keijzers; Mark P Mattson; Vilhelm A Bohr
Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.
The Journal of biological chemistry 2010;285(36):28191-9.
2010: Brian R Berquist; Dharmendra Kumar Singh; JINSHUI FAN; Daemyung Kim; Elizabeth Gillenwater; Avanti Kulkarni; Vilhelm A Bohr; Eric J Ackerman; Alan E Tomkinson; David M Wilson
Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population.
Nucleic acids research 2010;38(15):5023-35.
2010: Scott Maynard; Nadja C de Souza-Pinto; Morten Scheibye-Knudsen; Vilhelm A Bohr
Mitochondrial base excision repair assays.
Methods (San Diego, Calif.) 2010;51(4):416-25.
2010: Ricardo Gredilla; Vilhelm A Bohr; Tinna Stevnsner
Mitochondrial DNA repair and association with aging--an update.
Experimental gerontology 2010;45(7-8):478-88.
2010: Tomas A Prolla; Vilhelm A Bohr; Nadja C de Souza-Pinto
Mitochondria and aging.
Mechanisms of ageing and development 2010;131(7-8):449-50.
2010: Nadja C de Souza-Pinto; Maria D Aamann; Tomasz Kulikowicz; Tinna V Stevnsner; Vilhelm A Bohr
Mitochondrial helicases and mitochondrial genome maintenance.
Mechanisms of ageing and development 2010;131(7-8):503-10.
2010: Marie L Rossi; Avik K Ghosh; Tomasz Kulikowicz; Deborah L Croteau; Vilhelm A Bohr
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding.
DNA repair 2010;9(7):796-804.
2010: Maria D Aamann; Martin M Sorensen; Christina Hvitby; Brian R Berquist; Meltem Muftuoglu; Jingyan Tian; Nadja C de Souza-Pinto; Morten Scheibye-Knudsen; David M Wilson; Tinna Stevnsner; Vilhelm A Bohr
Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(7):2334-46.
2010: Venkateswarlu Popuri; Deborah L Croteau; Vilhelm A Bohr
Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases.
DNA repair 2010;9(6):636-42.
2010: Dharmendra Kumar Singh; parimal karmakar; Maria Aamann; Shepherd H Schurman; Alfred May; Deborah L Croteau; Lynnette Burks; Sharon E Plon; Vilhelm A Bohr
The involvement of human RECQL4 in DNA double-strand break repair.
Aging cell 2010;9(3):358-71.
2010: Rika Kusumoto-Matsuo; Patricia L Opresko; Dale Ramsden; Hidetoshi Tahara; Vilhelm A Bohr
Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops.
Aging 2010;2(5):274-84.
2010: Elzbieta Speina; Lale Dawut; Mohammad Hedayati; Zhengming Wang; Alfred May; Sybille Schwendener; Pavel Janscak; Deborah L Croteau; Vilhelm A Bohr
Human RECQL5beta stimulates flap endonuclease 1.
Nucleic acids research 2010;38(9):2904-16.
2010: Wen-Hsing Cheng; Vilhelm A Bohr; Rafael de Cabo
Nutrition and aging.
Mechanisms of ageing and development 2010;131(4):223-4.
2010: Marie L Rossi; Avik K Ghosh; Vilhelm A Bohr
Roles of Werner syndrome protein in protection of genome integrity.
DNA repair 2010;9(3):331-44.
2010: Rodney L Levine; Vilhelm A Bohr
Earl R. Stadtman.
Mechanisms of ageing and development 2010;131(1):1.
2009: Lior Weissman; Nadja C de Souza-Pinto; Mark P Mattson; Vilhelm A Bohr
DNA base excision repair activities in mouse models of Alzheimer's disease.
Neurobiology of aging 2009;30(12):2080-1.
2009: Avik Ghosh; Marie L Rossi; Jason Aulds; Deborah Croteau; Vilhelm A Bohr
Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1.
The Journal of biological chemistry 2009;284(45):31074-84.
2009: Shepherd H Schurman; Mohammad Hedayati; ZhengMing Wang; Dharmendra K Singh; Elzbieta Speina; Yongqing Zhang; Kevin Becker; Margaret Macris-Kiss; Patrick Sung; David Michael Wilson; Deborah L Croteau; Vilhelm A Bohr
Direct and indirect roles of RECQL4 in modulating base excision repair capacity.
Human molecular genetics 2009;18(18):3470-83.
2009: Kasper Kyng; Deborah L Croteau; Vilhelm A Bohr
Werner syndrome resembles normal aging.
Cell cycle (Georgetown, Tex.) 2009;8(15):2323.
2009: Nadja C de Souza-Pinto; Scott Maynard; Kazunari Hashiguchi; Jingping Hu; Meltem Muftuoglu; Vilhelm A Bohr
The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells.
Molecular and cellular biology 2009;29(16):4441-54.
2009: Mette Soerensen; Ricardo Gredilla; Mathis Müller-Ohldach; Alexandra Werner; Vilhelm A Bohr; Heinz D Osiewacz; Tinna Stevnsner
A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: decrease in mitochondrial DNA repair activity during ageing.
Mechanisms of ageing and development 2009;130(8):487-96.
2009: Leena Maddukuri; Elzbieta Speina; Mette Christiansen; Dominika Dudzińska; Jolanta Zaim; Tomasz Obtułowicz; Sylwia Kabaczyk; Marek Komisarski; Zuzanna Bukowy; Jadwiga Szczegielniak; Andrzej Wójcik; Jaroslaw T Kuśmierek; Tinna Stevnsner; Vilhelm A Bohr; Barbara Tudek
Cockayne syndrome group B protein is engaged in processing of DNA adducts of lipid peroxidation product trans-4-hydroxy-2-nonenal.
Mutation research 2009;666(1-2):23-31.
2009: Nadja C de Souza-Pinto; Penelope A Mason; Kazunari Hashiguchi; Lior Weissman; Jingyan Tian; David Guay; Michel Lebel; Tinna V Stevnsner; Lene Juel Rasmussen; Vilhelm A Bohr
Novel DNA mismatch-repair activity involving YB-1 in human mitochondria.
DNA repair 2009;8(6):704-19.
2009: Dharmendra Kumar Singh; Byungchan Ahn; Vilhelm A Bohr
Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging.
Biogerontology 2009;10(3):235-52.
2009: Niels Rasmussen; Thomas Hjuler; Vilhelm A Bohr; Per Cayé-Thomasen
[Is the concept "otogenic meningitis" a misunderstanding?].
Ugeskrift for laeger 2009;171(18):1480.
2009: Meltem Muftuoglu; Nadja C de Souza-Pinto; Arin Dogan; Maria Aamann; Tinna Stevnsner; Ivana Rybanska; Guldal KIRKALI; Miral Dizdaroglu; Vilhelm A Bohr
Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase.
The Journal of biological chemistry 2009;284(14):9270-9.
2009: Guldal KIRKALI; Nadja C de Souza-Pinto; Pawel Jaruga; Vilhelm A Bohr; Miral Dizdaroglu
Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice.
DNA repair 2009;8(2):274-8.
2009: Ronald A McCord; Eriko Michishita; Tao Hong; Elisabeth Berber; Lisa D Boxer; Rika Kusumoto; Shenheng Guan; Xiaobing Shi; Or Gozani; Alma L Burlingame; Vilhelm A Bohr; Katrin F Chua
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.
Aging 2009;1(1):109-21.
2009: Byungchan Ahn; Jae Wan Lee; Hana Jung; Gad Beck; Vilhelm A Bohr
Mechanism of Werner DNA helicase: POT1 and RPA stimulates WRN to unwind beyond gaps in the translocating strand.
PloS one 2009;4(3):e4673.
2009: Scott Maynard; Shepherd H Schurman; Charlotte Harboe; Nadja C de Souza-Pinto; Vilhelm A Bohr
Base excision repair of oxidative DNA damage and association with cancer and aging.
Carcinogenesis 2009;30(1):2-10.
2008: Vilhelm A Bohr
Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance.
Trends in biochemical sciences 2008;33(12):609-20.
2008: Markus Christmann; Maja T Tomicic; Christopher Gestrich; Wynand Roos; Vilhelm A Bohr; Bernd Kaina
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.
DNA repair 2008;7(12):1999-2009.
2008: Linda P Fried; Ravi Varadhan; Vilhelm A Bohr
Opinion section on frailty.
Mechanisms of ageing and development 2008;129(11):665.
2008: Meltem Muftuoglu; Oshima Junko; Cayetano von Kobbe; Wen-Hsing Cheng; Dru F Leistritz; Vilhelm A Bohr
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis.
Human genetics 2008;124(4):369-77.
2008: Gregory J Aune; Kazutaka Takagi; Olivier Sordet; Josée Guirouilh-Barbat; Smitha Antony; Vilhelm A Bohr; Yves Pommier
Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6449-55.
2008: Miriam Sander; Kirsten Avlund; Martin Lauritzen; Tina Gottlieb; Barry Halliwell; Tinna Stevnsner; Ulla Wewer; Vilhelm A Bohr
Aging-from molecules to populations.
Mechanisms of ageing and development 2008;129(10):614-23.
2008: Meltem Muftuoglu; Tomasz Kulikowicz; Gad Beck; Jae Wan Lee; Jason Piotrowski; Vilhelm A Bohr
Intrinsic ssDNA annealing activity in the C-terminal region of WRN.
Biochemistry 2008;47(39):10247-54.
2008: Zuzanna Bukowy; Jeanine A Harrigan; Dale A Ramsden; Barbara Tudek; Vilhelm A Bohr; Tinna Stevnsner
WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand.
Nucleic acids research 2008;36(15):4975-87.
2008: Wen-Hsing Cheng; Diana Muftic; Meltem Muftuoglu; Lale Dawut; Christa Morris; Thomas Helleday; Yosef Shiloh; Vilhelm A Bohr
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.
Molecular biology of the cell 2008;19(9):3923-33.
2008: Scott Maynard; Anna Maria Swistowska; Jae Wan Lee; Ying Liu; Su-Ting Liu; Alexandre Bettencourt Da Cruz; Mahendra S Rao; Nadja C de Souza-Pinto; Xianmin Zeng; Vilhelm A Bohr
Human embryonic stem cells have enhanced repair of multiple forms of DNA damage.
Stem cells (Dayton, Ohio) 2008;26(9):2266-74.
2008: Pingfang Liu; Limin Qian; Jung-Suk Sung; Nadja C de Souza-Pinto; Li Zheng; Daniel F Bogenhagen; Vilhelm A Bohr; David Michael Wilson; Binghui Shen; Bruce Demple
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria.
Molecular and cellular biology 2008;28(16):4975-87.
2008: Rika Kusumoto; Lale Dawut; Caterina Marchetti; Jae Wan Lee; Alessandro Vindigni; Dale A Ramsden; Vilhelm A Bohr
Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing.
Biochemistry 2008;47(28):7548-56.
2008: Moonjung Hyun; Vilhelm A Bohr; Byungchan Ahn
Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans.
Biochemistry 2008;47(28):7583-93.
2008: Tinna Stevnsner; Meltem Muftuoglu; Maria Diget Aamann; Vilhelm A Bohr
The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging.
Mechanisms of ageing and development 2008;129(7-8):441-8.
2008: Nadja C de Souza-Pinto; David Michael Wilson; Tinna V Stevnsner; Vilhelm A Bohr
Mitochondrial DNA, base excision repair and neurodegeneration.
DNA repair 2008;7(7):1098-109.
2008: Jenq-Lin Yang; Lior Weissman; Vilhelm A Bohr; Mark P Mattson
Mitochondrial DNA damage and repair in neurodegenerative disorders.
DNA repair 2008;7(7):1110-20.
2008: David Michael Wilson; Vilhelm A Bohr; Peter J McKinnon
DNA damage, DNA repair, ageing and age-related disease.
Mechanisms of ageing and development 2008;129(7-8):349-52.
2008: Eriko Michishita; Ronald A McCord; Elisabeth Berber; Mitomu Kioi; Hesed Padilla-Nash; Mara Damian; Peggie Cheung; Rika Kusumoto; Tiara L A Kawahara; J Carl Barrett; Howard Y Chang; Vilhelm A Bohr; Thomas Ried; Or Gozani; Katrin F Chua
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Nature 2008;452(7186):492-6.
2008: Moonjung Hyun; Jihyun Lee; Kyungjin Lee; Alfred May; Vilhelm A Bohr; Byungchan Ahn
Longevity and resistance to stress correlate with DNA repair capacity in Caenorhabditis elegans.
Nucleic acids research 2008;36(4):1380-9.
2008: Meltem Muftuoglu; Rika Kusumoto; Elzbieta Speina; Gad Beck; Wen-Hsing Cheng; Vilhelm A Bohr
Acetylation regulates WRN catalytic activities and affects base excision DNA repair.
PloS one 2008;3(4):e1918.
2008: Yie Liu; Vilhelm A Bohr; Peter Lansdorp
Telomere, telomerase and aging.
Mechanisms of ageing and development 2008;129(1-2):1-2.
2007: Jeanine A Harrigan; Jason Piotrowski; Luca Di Noto; Rodney L Levine; Vilhelm A Bohr
Metal-catalyzed oxidation of the Werner syndrome protein causes loss of catalytic activities and impaired protein-protein interactions.
The Journal of biological chemistry 2007;282(50):36403-11.
2007: Mandy Pereira; Penelope Mason; Roman Szczesny; Leena Maddukuri; Sylwia Dziwura; Robert Jedrzejczak; Erin Paul; Andrzej Wojcik; Lien Dybczynska; Barbara Tudek; Ewa Bartnik; Jan Klysik; Vilhelm A Bohr; Piotr P Stepien
Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.
Mechanisms of ageing and development 2007;128(11-12):609-17.
2007: Hongying Yang; Tianle Yang; Joseph A Baur; Evelyn Perez; Takashi Matsui; Juan J Carmona; Dudley W Lamming; Nadja C Souza-Pinto; Vilhelm A Bohr; Anthony Rosenzweig; Rafael de Cabo; Anthony A Sauve; David A Sinclair
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.
Cell 2007;130(6):1095-107.
2007: Aditi Das; Istvan Boldogh; Jae Wan Lee; Jeanine A Harrigan; Muralidhar Hegde; Jason Piotrowski; Nadja C de Souza-Pinto; William Ramos; Marc M Greenberg; Tapas K Hazra; Sankar Mitra; Vilhelm A Bohr
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1.
The Journal of biological chemistry 2007;282(36):26591-602.
2007: Wen-Hsing Cheng; Meltem Muftuoglu; Vilhelm A Bohr
Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.
Experimental gerontology 2007;42(9):871-8.
2007: Renjie Jiao; Jeanine A Harrigan; Igor Shevelev; Tobias Dietschy; N Selak; Fred E Indig; Jason Piotrowski; Pavel Janscak; Vilhelm A Bohr; Igor Stagljar
The Werner syndrome protein is required for recruitment of chromatin assembly factor 1 following DNA damage.
Oncogene 2007;26(26):3811-22.
2007: Vilhelm A Bohr; O P Ottersen; T Tønjum
Genome instability and DNA repair in brain, ageing and neurological disease.
Neuroscience 2007;145(4):1183-6.
2007: L Weissman; Nadja C de Souza-Pinto; Tinna Stevnsner; Vilhelm A Bohr
DNA repair, mitochondria, and neurodegeneration.
Neuroscience 2007;145(4):1318-29.
2007: Rudaina H Alrefai; David B Winter; Vilhelm A Bohr; Patricia J Gearhart
Nucleotide excision repair in an immunoglobulin variable gene is less efficient than in a housekeeping gene.
Molecular immunology 2007;44(11):2800-5.
2007: David Michael Wilson; Vilhelm A Bohr
The mechanics of base excision repair, and its relationship to aging and disease.
DNA repair 2007;6(4):544-59.
2007: Jeanine A Harrigan; JINSHUI FAN; Jamil Momand; Fred W Perrino; Vilhelm A Bohr; David Michael Wilson
WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups.
Mechanisms of ageing and development 2007;128(3):259-66.
2007: Kenneth H Kraemer; Miriam Sander; Vilhelm A Bohr
New areas of focus at workshop on human diseases involving DNA repair deficiency and premature aging.
Mechanisms of ageing and development 2007;128(2):229-35.
2007: Robert M Brosh; Vilhelm A Bohr
Human premature aging, DNA repair and RecQ helicases.
Nucleic acids research 2007;35(22):7527-44.
2007: Lior Weissman; Dong-Gyu Jo; Martin M Sørensen; Nadja C de Souza-Pinto; William R Markesbery; Mark P Mattson; Vilhelm A Bohr
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment.
Nucleic acids research 2007;35(16):5545-55.
2007: Syed Z Imam; Fred E Indig; Wen-Hsing Cheng; Satya P Saxena; Tinna Stevnsner; Donald Kufe; Vilhelm A Bohr
Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase.
Nucleic acids research 2007;35(15):4941-51.
2007: Heng-Kuan Wong; Meltem Muftuoglu; Gad Beck; Syed Z Imam; Vilhelm A Bohr; David Michael Wilson
Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates.
Nucleic acids research 2007;35(12):4103-13.
2007: Rika Kusumoto; Meltem Muftuoglu; Vilhelm A Bohr
The role of WRN in DNA repair is affected by post-translational modifications.
Mechanisms of ageing and development 2007;128(1):50-7.
2006: Marit Otterlei; Per Bruheim; Byungchan Ahn; Wendy Bussen; parimal karmakar; Kathy Baynton; Vilhelm A Bohr
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Journal of cell science 2006;119(Pt 24):5137-46.
2006: Mark S Eller; Xiaodong Liao; SuiYang Liu; Kendra Hanna; Helena Bäckvall; Patricia L Opresko; Vilhelm A Bohr; Barbara A Gilchrest
A role for WRN in telomere-based DNA damage responses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15073-8.
2006: H Joachim Deeg; Debra Friedman; Vilhelm A Bohr; Louis S Constine; Irene M Jones; Alice Sigurdson; Gérard Socié; Gary Van Zant; Qingyi Wei; Paul Martin
Transplantation and aging.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(9):893-8.
2006: Syed Z Imam; Bensu Karahalil; Barbara A Hogue; Nadja C Souza-Pinto; Vilhelm A Bohr
Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner.
Neurobiology of aging 2006;27(8):1129-36.
2006: Lene Juel Rasmussen; Tinna Stevnsner; Vilhelm A Bohr
[DNA repair--a fundamental factor in ageing and development of cancer].
Ugeskrift for laeger 2006;168(24):2332-5.
2006: Ruben Agrelo; Wen-Hsing Cheng; Fernando Setien; Santiago Ropero; Jesus Espada; Mario F Fraga; Michel Herranz; Maria Fe Paz; Montserrat Sanchez-Cespedes; María-Jesús Artiga; David Guerrero; Antoni Castells; Cayetano von Kobbe; Vilhelm A Bohr; Manel Esteller
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(23):8822-7.
2006: Fuki M Hisama; Vilhelm A Bohr; Oshima Junko
WRN's tenth anniversary.
Science of aging knowledge environment : SAGE KE 2006;2006(10):pe18.
2006: Jiri Lukas; Vilhelm A Bohr; Thanos D Halazonetis
Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium.
DNA repair 2006;5(5):591-601.
2006: Peisu Zhang; Katsutoshi Furukawa; Patricia L Opresko; Xiangru Xu; Vilhelm A Bohr; Mark P Mattson
TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons.
Journal of neurochemistry 2006;97(2):567-81.
2006: Elisa A Spillare; Xin Wei Wang; C von Kobbe; Vilhelm A Bohr; Ian D Hickson; Curtis C Harris
Redundancy of DNA helicases in p53-mediated apoptosis.
Oncogene 2006;25(14):2119-23.
2006: Claus Bischoff; Hans Christian Petersen; Jesper Graakjaer; Karen Andersen-Ranberg; James W Vaupel; Vilhelm A Bohr; Steen Kølvraa; Kaare Christensen
No association between telomere length and survival among the elderly and oldest old.
Epidemiology (Cambridge, Mass.) 2006;17(2):190-4.
2006: Robert M Brosh; Patricia L Opresko; Vilhelm A Bohr
Enzymatic mechanism of the WRN helicase/nuclease.
Methods in enzymology 2006;409():52-85.
2006: Wen-Hsing Cheng; Rika Kusumoto; Patricia L Opresko; XiuFen Sui; Shurong Huang; Matthew L Nicolette; Tanya T Paull; Judith Campisi; Michael M Seidman; Vilhelm A Bohr
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links.
Nucleic acids research 2006;34(9):2751-60.
2006: Robert Michael Anson; Penelope A Mason; Vilhelm A Bohr
Gene-specific and mitochondrial repair of oxidative DNA damage.
Methods in molecular biology (Clifton, N.J.) 2006;314():155-81.
2006: Jeanine A Harrigan; David Michael Wilson; Rajendra Prasad; Patricia L Opresko; Gad Beck; Alfred May; Samuel H Wilson; Vilhelm A Bohr
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta.
Nucleic acids research 2006;34(2):745-54.
2006: Meltem Muftuoglu; Sudha Sharma; Tina Thorslund; Tinna Stevnsner; Martin M Soerensen; Robert M Brosh; Vilhelm A Bohr
Cockayne syndrome group B protein has novel strand annealing and exchange activities.
Nucleic acids research 2006;34(1):295-304.
2006: Meltem Muftuoglu; Heng-Kuan Wong; Syed Z Imam; David Michael Wilson; Vilhelm A Bohr; Patricia L Opresko
Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta.
Cancer research 2006;66(1):113-24.
2005: Jingping Hu; Nadja C de Souza-Pinto; Kazuhiro Haraguchi; Barbara A Hogue; Pawel Jaruga; Marc M Greenberg; Miral Dizdaroglu; Vilhelm A Bohr
Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes.
The Journal of biological chemistry 2005;280(49):40544-51.
2005: Jae Wan Lee; Rika Kusumoto; Kevin M Doherty; Guang-Xin Lin; Wangyong Zeng; Wen-Hsing Cheng; Cayetano von Kobbe; Robert M Brosh; Jin-Shan Hu; Vilhelm A Bohr
Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain.
The Journal of biological chemistry 2005;280(47):39627-36.
2005: Kasper Jacobsen Kyng; Vilhelm A Bohr
Gene expression and DNA repair in progeroid syndromes and human aging.
Ageing research reviews 2005;4(4):579-602.
2005: parimal karmakar; Vilhelm A Bohr
Cellular dynamics and modulation of WRN protein is DNA damage specific.
Mechanisms of ageing and development 2005;126(11):1146-58.
2005: Claus Bischoff; Jesper Graakjaer; Hans Christian Petersen; Bernard Jeune; Vilhelm A Bohr; Steen Koelvraa; Kaare Christensen
Telomere length among the elderly and oldest-old.
Twin research and human genetics : the official journal of the International Society for Twin Studies 2005;8(5):425-32.
2005: Patricia L Opresko; Penelope A Mason; Elaine R Podell; Ming Lei; Ian D Hickson; Thomas R Cech; Vilhelm A Bohr
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
The Journal of biological chemistry 2005;280(37):32069-80.
2005: Vilhelm A Bohr
Deficient DNA repair in the human progeroid disorder, Werner syndrome.
Mutation research 2005;577(1-2):252-9.
2005: Mette Christiansen; Tina Thorslund; Bjarne Jochimsen; Vilhelm A Bohr; Tinna Stevnsner
The Cockayne syndrome group B protein is a functional dimer.
The FEBS journal 2005;272(17):4306-14.
2005: Tina Thorslund; Cayetano von Kobbe; Jeanine A Harrigan; Fred E Indig; Mette Christiansen; Tinna Stevnsner; Vilhelm A Bohr
Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.
Molecular and cellular biology 2005;25(17):7625-36.
2005: Kasper Jacobsen Kyng; Alfred May; Tinna Stevnsner; Kevin G Becker; Steen Kølvrå; Vilhelm A Bohr
Gene expression responses to DNA damage are altered in human aging and in Werner Syndrome.
Oncogene 2005;24(32):5026-42.
2005: Leonard Wu; Kok-Lung Chan; Christine Ralf; Douglas A Bernstein; Patrick L Garcia; Vilhelm A Bohr; Alessandro Vindigni; Pavel Janscak; James L Keck; Ian D Hickson
The HRDC domain of BLM is required for the dissolution of double Holliday junctions.
The EMBO journal 2005;24(14):2679-87.
2005: Elizabeth Mambo; Aditi Chatterjee; Nadja C de Souza-Pinto; Sabine Mayard; Barbara A Hogue; Mohammad Hoque; Miral Dizdaroglu; Vilhelm A Bohr; David Sidransky
Oxidized guanine lesions and hOgg1 activity in lung cancer.
Oncogene 2005;24(28):4496-508.
2005: Kenneth H Kraemer; Vilhelm A Bohr
The DNA Repair Interest Group: a global village.
DNA repair 2005;4(4):405-6.
2005: Jeffrey A Stuart; B M Bourque; Nadja C de Souza-Pinto; Vilhelm A Bohr
No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA.
Free radical biology & medicine 2005;38(6):737-45.
2005: Wen-Hsing Cheng; Shuichi Sakamoto; Jennifer T Fox; Kenshi Komatsu; James P Carney; Vilhelm A Bohr
Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.
FEBS letters 2005;579(6):1350-6.
2005: Vilhelm A Bohr; Miriam Sander; Kenneth H Kraemer
Rare diseases provide rare insights into DNA repair pathways, TFIIH, aging and cancer center.
DNA repair 2005;4(2):293-302.
2005: Jeffrey A Stuart; S Mayard; Kazunari Hashiguchi; Nadja C Souza-Pinto; Vilhelm A Bohr
Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction.
Nucleic acids research 2005;33(12):3722-32.
2005: Jingping Hu; Syed Z Imam; Kazunari Hashiguchi; Nadja C de Souza-Pinto; Vilhelm A Bohr
Phosphorylation of human oxoguanine DNA glycosylase (alpha-OGG1) modulates its function.
Nucleic acids research 2005;33(10):3271-82.
2005: Patricia L Opresko; JINSHUI FAN; Shamika Danzy; David Michael Wilson; Vilhelm A Bohr
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2.
Nucleic acids research 2005;33(4):1230-9.
2005: Jae Wan Lee; Jeanine A Harrigan; Patricia L Opresko; Vilhelm A Bohr
Pathways and functions of the Werner syndrome protein.
Mechanisms of ageing and development 2005;126(1):79-86.
2004: Byungchan Ahn; Jeanine A Harrigan; Fred E Indig; David Michael Wilson; Vilhelm A Bohr
Regulation of WRN helicase activity in human base excision repair.
The Journal of biological chemistry 2004;279(51):53465-74.
2004: Cayetano von Kobbe; Alfred May; Carla Grandori; Vilhelm A Bohr
Werner syndrome cells escape hydrogen peroxide-induced cell proliferation arrest.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(15):1970-2.
2004: Nadja C de Souza-Pinto; Curtis C Harris; Vilhelm A Bohr
p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria.
Oncogene 2004;23(39):6559-68.
2004: Kazunari Hashiguchi; Vilhelm A Bohr; Nadja C de Souza-Pinto
Oxidative stress and mitochondrial DNA repair: implications for NRTIs induced DNA damage.
Mitochondrion 2004;4(2-3):215-22.
2004: Vilhelm A Bohr; E Jeffrey Metter; Jeanine A Harrigan; Cayetano von Kobbe; Ji Lan Liu; Matthew D Gray; Alokes Majumdar; David Michael Wilson; Michael M Seidman
Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients.
Mechanisms of ageing and development 2004;125(7):491-6.
2004: Mette H Bendixen; Bjørn A Nexø; Vilhelm A Bohr; Henrik Frederiksen; Matt McGue; Steen Kølvraa; Kaare Christensen
A polymorphic marker in the first intron of the Werner gene associates with cognitive function in aged Danish twins.
Experimental gerontology 2004;39(7):1101-7.
2004: Wen-Hsing Cheng; Cayetano von Kobbe; Patricia L Opresko; L Matthew Arthur; Kenshi Komatsu; Michael M Seidman; James P Carney; Vilhelm A Bohr
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.
The Journal of biological chemistry 2004;279(20):21169-76.
2004: Vilhelm A Bohr; Nadja Souza-Pinto; Samuel Wilson
First US-EU DNA repair meeting: endogenous stress, National Conference Center, VA, USA, 14-18 October 2003.
DNA repair 2004;3(5):543-59.
2004: Patricia L Opresko; Wen-Hsing Cheng; Vilhelm A Bohr
Junction of RecQ helicase biochemistry and human disease.
The Journal of biological chemistry 2004;279(18):18099-102.
2004: Fred E Indig; Juneth Joaquin Partridge; Cayetano von Kobbe; Mirit I Aladjem; Martin Latterich; Vilhelm A Bohr
Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion.
Journal of structural biology 2004;146(1-2):251-9.
2004: Sudha Sharma; Joshua Sommers; Leonard Wu; Vilhelm A Bohr; Ian D Hickson; Robert M Brosh
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein.
The Journal of biological chemistry 2004;279(11):9847-56.
2004: Jeffrey A Stuart; Bensu Karahalil; Barbara A Hogue; Nadja C Souza-Pinto; Vilhelm A Bohr
Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(3):595-7.
2004: Kazunari Hashiguchi; Jeffrey A Stuart; Nadja C de Souza-Pinto; Vilhelm A Bohr
The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity.
Nucleic acids research 2004;32(18):5596-608.
2004: Cayetano von Kobbe; Jeanine A Harrigan; Valérie Schreiber; Patrick Stiegler; Jason Piotrowski; Lale Dawut; Vilhelm A Bohr
Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.
Nucleic acids research 2004;32(13):4003-14.
2004: Jeffrey A Stuart; Kazunari Hashiguchi; David Michael Wilson; W C Copeland; Nadja C Souza-Pinto; Vilhelm A Bohr
DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA.
Nucleic acids research 2004;32(7):2181-92.
2003: Cayetano von Kobbe; Nicolas H Thomä; Bryan Czyzewski; Nikola P Pavletich; Vilhelm A Bohr
Werner syndrome protein contains three structure-specific DNA binding domains.
The Journal of biological chemistry 2003;278(52):52997-3006.
2003: Vilhelm A Bohr
Werner syndrome and its protein: clinical, cellular and molecular advances.
Mechanisms of ageing and development 2003;124(10-12):1073-82.
2003: Cecilie Licht; Tinna Stevnsner; Vilhelm A Bohr
Cockayne syndrome group B cellular and biochemical functions.
American journal of human genetics 2003;73(6):1217-39.
2003: Cayetano von Kobbe; Jeanine A Harrigan; Alfred May; Patricia L Opresko; Lale Dawut; Wen-Hsing Cheng; Vilhelm A Bohr
Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.
Molecular and cellular biology 2003;23(23):8601-13.
2003: Jeanine A Harrigan; Vilhelm A Bohr
Human diseases deficient in RecQ helicases.
Biochimie 2003;85(11):1185-93.
2003: Jean-Philippe Laine; Patricia L Opresko; Fred E Indig; Jeanine A Harrigan; Cayetano von Kobbe; Vilhelm A Bohr
Werner protein stimulates topoisomerase I DNA relaxation activity.
Cancer research 2003;63(21):7136-46.
2003: Kasper Jacobsen Kyng; Alfred May; Steen Kølvraa; Vilhelm A Bohr
Gene expression profiling in Werner syndrome closely resembles that of normal aging.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12259-64.
2003: Kathy Baynton; Marit Otterlei; Magnar Bjørås; Cayetano von Kobbe; Vilhelm A Bohr; Erling Seeberg
WRN interacts physically and functionally with the recombination mediator protein RAD52.
The Journal of biological chemistry 2003;278(38):36476-86.
2003: Bensu Karahalil; Nadja C de Souza-Pinto; Jason L Parsons; Rhoderick H Elder; Vilhelm A Bohr
Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases.
The Journal of biological chemistry 2003;278(36):33701-7.
2003: Wen-Hsing Cheng; Cayetano von Kobbe; Patricia L Opresko; Kesha M Fields; Jian Ren; Donald Kufe; Vilhelm A Bohr
Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution.
Molecular and cellular biology 2003;23(18):6385-95.
2003: Wen-Hsing Cheng; Vilhelm A Bohr
Diverse dealings of the Werner helicase/nuclease.
Science of aging knowledge environment : SAGE KE 2003;2003(31):PE22.
2003: Jeanine A Harrigan; Patricia L Opresko; Cayetano von Kobbe; Padmini S Kedar; Rajendra Prasad; Samuel H Wilson; Vilhelm A Bohr
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity.
The Journal of biological chemistry 2003;278(25):22686-95.
2003: Anne Jensen; Guillaume Calvayrac; Bensu Karahalil; Vilhelm A Bohr; Tinna Stevnsner
Mammalian 8-oxoguanine DNA glycosylase 1 incises 8-oxoadenine opposite cytosine in nuclei and mitochondria, while a different glycosylase incises 8-oxoadenine opposite guanine in nuclei.
The Journal of biological chemistry 2003;278(21):19541-8.
2003: Patricia L Opresko; Wen-Hsing Cheng; Cayetano von Kobbe; Jeanine A Harrigan; Vilhelm A Bohr
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.
Carcinogenesis 2003;24(5):791-802.
2003: Jesper Graakjaer; Claus Bischoff; Lars Korsholm; Søren Holstebroe; Werner Vach; Vilhelm A Bohr; Kaare Christensen; Steen Kølvraa
The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life.
Mechanisms of ageing and development 2003;124(5):629-40.
2003: Jingsheng Tuo; Pawel Jaruga; Henry Rodriguez; Vilhelm A Bohr; Miral Dizdaroglu
Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):668-74.
2003: Kasper Jacobsen Kyng; Alfred May; Robert M Brosh; Wen-Hsing Cheng; Catheryne Chen; Kevin G Becker; Vilhelm A Bohr
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells.
Oncogene 2003;22(8):1135-49.
2003: Mette Christiansen; Tinna Stevnsner; Charlotte Modin; Pia M Martensen; Robert M Brosh; Vilhelm A Bohr
Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein.
Nucleic acids research 2003;31(3):963-73.
2002: Tinna Stevnsner; Simon G Nyaga; Nadja C de Souza-Pinto; Gijsbertus T J van der Horst; Theo G M F Gorgels; Barbara A Hogue; Tina Thorslund; Vilhelm A Bohr
Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B.
Oncogene 2002;21(57):8675-82.
2002: Bensu Karahalil; Barbara A Hogue; Nadja C de Souza-Pinto; Vilhelm A Bohr
Base excision repair capacity in mitochondria and nuclei: tissue-specific variations.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1895-902.
2002: Jingsheng Tuo; Catheryne Chen; Xianmin Zeng; Mette Christiansen; Vilhelm A Bohr
Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein.
DNA repair 2002;1(11):913-27.
2002: Patricia L Opresko; Cayetano von Kobbe; Jean-Philippe Laine; Jeanine A Harrigan; Ian D Hickson; Vilhelm A Bohr
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.
The Journal of biological chemistry 2002;277(43):41110-9.
2002: Cayetano von Kobbe; Vilhelm A Bohr
A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092.
Journal of cell science 2002;115(Pt 20):3901-7.
2002: Tinna Stevnsner; Tina Thorslund; Nadja C de Souza-Pinto; Vilhelm A Bohr
Mitochondrial repair of 8-oxoguanine and changes with aging.
Experimental gerontology 2002;37(10-11):1189-96.
2002: Qin Yang; Ran Zhang; Xin Wei Wang; Elisa A Spillare; Steven P Linke; Deepa Subramanian; Jack D Griffith; Ji Liang Li; Ian D Hickson; Jiang Cheng Shen; Lawrence A Loeb; Sharlyn J Mazur; Ettore Appella; Robert M Brosh; parimal karmakar; Vilhelm A Bohr; Curtis C Harris
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.
The Journal of biological chemistry 2002;277(35):31980-7.
2002: Jingsheng Tuo; Pawel Jaruga; Henry Rodriguez; Miral Dizdaroglu; Vilhelm A Bohr
The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA.
The Journal of biological chemistry 2002;277(34):30832-7.
2002: parimal karmakar; Carey M Snowden; Dale A Ramsden; Vilhelm A Bohr
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.
Nucleic acids research 2002;30(16):3583-91.
2002: Cayetano von Kobbe; parimal karmakar; Lale Dawut; Patricia L Opresko; Xianmin Zeng; Robert M Brosh; Ian D Hickson; Vilhelm A Bohr
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.
The Journal of biological chemistry 2002;277(24):22035-44.
2002: parimal karmakar; Jason Piotrowski; Robert M Brosh; Joshua Sommers; Susan P Lees Miller; Wen-Hsing Cheng; Carey M Snowden; Dale A Ramsden; Vilhelm A Bohr
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation.
The Journal of biological chemistry 2002;277(21):18291-302.
2002: Morten Sunesen; Tinna Stevnsner; Robert M Brosh; Grigory L Dianov; Vilhelm A Bohr
Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product.
Oncogene 2002;21(22):3571-8.
2002: Vilhelm A Bohr
DNA-related pathways defective in human premature aging.
TheScientificWorldJournal 2002;2():1216-26.
2002: Vilhelm A Bohr
Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells.
Free radical biology & medicine 2002;32(9):804-12.
2002: Vilhelm A Bohr
Human premature aging syndromes and genomic instability.
Mechanisms of ageing and development 2002;123(8):987-93.
2002: Tina Thorslund; Morten Sunesen; Vilhelm A Bohr; Tinna Stevnsner
Repair of 8-oxoG is slower in endogenous nuclear genes than in mitochondrial DNA and is without strand bias.
DNA repair 2002;1(4):261-73.
2002: Robert M Brosh; Vilhelm A Bohr
Roles of the Werner syndrome protein in pathways required for maintenance of genome stability.
Experimental gerontology 2002;37(4):491-506.
2002: Vilhelm A Bohr; Tinna Stevnsner; Nadja C de Souza-Pinto
Mitochondrial DNA repair of oxidative damage in mammalian cells.
Gene 2002;286(1):127-34.
2002: Elizabeth Mambo; Simon G Nyaga; Vilhelm A Bohr; Michele K Evans
Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines.
Cancer research 2002;62(5):1349-55.
2002: Rebecca R Selzer; Simon G Nyaga; Jingsheng Tuo; Alfred May; Meltem Muftuoglu; Mette Christiansen; Elisabetta Citterio; Robert M Brosh; Vilhelm A Bohr
Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells.
Nucleic acids research 2002;30(3):782-93.
2002: Meltem Muftuoglu; Rebecca R Selzer; Jingsheng Tuo; Robert M Brosh; Vilhelm A Bohr
Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene.
Gene 2002;283(1-2):27-40.
2002: Nadja C de Souza-Pinto; Vilhelm A Bohr
The mitochondrial theory of aging: involvement of mitochondrial DNA damage and repair.
International review of neurobiology 2002;53():519-34.
2002: Vilhelm A Bohr; Robert M Brosh; Cayetano von Kobbe; Patricia L Opresko; parimal karmakar
Pathways defective in the human premature aging disease Werner syndrome.
Biogerontology 2002;3(1-2):89-94.
2002: Simon G Nyaga; Vilhelm A Bohr
Characterization of specialized mtDNA glycosylases.
Methods in molecular biology (Clifton, N.J.) 2002;197():227-44.
2001: Jingsheng Tuo; M Müftüoglu; C Chen; Pawel Jaruga; Rebecca R Selzer; Robert M Brosh; Henry Rodriguez; Miral Dizdaroglu; Vilhelm A Bohr
The Cockayne Syndrome group B gene product is involved in general genome base excision repair of 8-hydroxyguanine in DNA.
The Journal of biological chemistry 2001;276(49):45772-9.
2001: Patricia L Opresko; Jean-Philippe Laine; Robert M Brosh; Michael M Seidman; Vilhelm A Bohr
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.
The Journal of biological chemistry 2001;276(48):44677-87.
2001: Irina I Dianova; Vilhelm A Bohr; Grigory L Dianov
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair.
Biochemistry 2001;40(42):12639-44.
2001: Robert M Brosh; Cayetano von Kobbe; Joshua Sommers; parimal karmakar; Patricia L Opresko; Jason Piotrowski; Irina I Dianova; Grigory L Dianov; Vilhelm A Bohr
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.
The EMBO journal 2001;20(20):5791-801.
2001: Kathleen L Gabrielson; Barbara A Hogue; Vilhelm A Bohr; Arturo J Cardounel; W Nakajima; Julia Kofler; Jay L Zweier; E Rene Rodriguez; Lee J Martin; Nadja C de Souza-Pinto; Joseph Bressler
Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice.
The American journal of pathology 2001;159(4):1507-20.
2001: Robert M Brosh; parimal karmakar; Joshua Sommers; Qin Yang; Xin Wei Wang; Elisa A Spillare; Curtis C Harris; Vilhelm A Bohr
p53 Modulates the exonuclease activity of Werner syndrome protein.
The Journal of biological chemistry 2001;276(37):35093-102.
2001: Karli Rosner; David B Winter; Gunhild Lange Skovgaard; Oshima Junko; Patricia J Gearhart; Vilhelm A Bohr
Analysis of microsatellite instability and hypermutation of immunoglobulin variable genes in Werner syndrome.
Mechanisms of ageing and development 2001;122(11):1121-33.
2001: Nadja C de Souza-Pinto; Lars Eide; Barbara A Hogue; T Thybo; Tinna Stevnsner; Erling Seeberg; Arne Klungland; Vilhelm A Bohr
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.
Cancer research 2001;61(14):5378-81.
2001: Karli Rosner; David B Winter; RE Tarone; Gunhild Lange Skovgaard; Vilhelm A Bohr; Patricia J Gearhart
Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes.
Immunology 2001;103(2):179-87.
2001: David K Orren; Amrita Machwe; parimal karmakar; Jason Piotrowski; MP Cooper; Vilhelm A Bohr
A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA.
Nucleic acids research 2001;29(9):1926-34.
2001: Nadja C de Souza-Pinto; Barbara A Hogue; Vilhelm A Bohr
DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts.
Free radical biology & medicine 2001;30(8):916-23.
2001: Andrej Podlutsky; Irina I Dianova; Vladimir N Podust; Vilhelm A Bohr; Grigory L Dianov
Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA.
The EMBO journal 2001;20(6):1477-82.
2001: Karli Rosner; David B Winter; Cynthia Kasmer; Gunhild Lange Skovgaard; RE Tarone; Vilhelm A Bohr; Patricia J Gearhart
Impact of age on hypermutation of immunoglobulin variable genes in humans.
Journal of clinical immunology 2001;21(2):102-15.
2001: Robert M Brosh; A Majumdar; S Desai; Ian D Hickson; Vilhelm A Bohr; M M Seidman
Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases.
The Journal of biological chemistry 2001;276(5):3024-30.
2001: Andrej Podlutsky; Irina I Dianova; Samuel H Wilson; Vilhelm A Bohr; Grigory L Dianov
DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts.
Biochemistry 2001;40(3):809-13.
2001: Vilhelm A Bohr; Nadja C Souza-Pinto; Simon G Nyaga; Grigory L Dianov; K Kraemer; Michael M Seidman; Robert M Brosh
DNA repair and mutagenesis in Werner syndrome.
Environmental and molecular mutagenesis 2001;38(2-3):227-34.
2001: Grigory L Dianov; Nadja C Souza-Pinto; Simon G Nyaga; T Thybo; Tinna Stevnsner; Vilhelm A Bohr
Base excision repair in nuclear and mitochondrial DNA.
Progress in nucleic acid research and molecular biology 2001;68():285-97.
2000: Vilhelm A Bohr; M Cooper; David K Orren; Amrita Machwe; Jason Piotrowski; Joshua Sommers; parimal karmakar; Robert M Brosh
Werner syndrome protein: biochemical properties and functional interactions.
Experimental gerontology 2000;35(6-7):695-702.
2000: Amrita Machwe; David K Orren; Vilhelm A Bohr
Accelerated methylation of ribosomal RNA genes during the cellular senescence of Werner syndrome fibroblasts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(12):1715-24.
2000: Morten Sunesen; Rebecca R Selzer; Robert M Brosh; Adayabalam S Balajee; Tinna Stevnsner; Vilhelm A Bohr
Molecular characterization of an acidic region deletion mutant of Cockayne syndrome group B protein.
Nucleic acids research 2000;28(16):3151-9.
2000: Robert M Brosh; Ji-Liang Li; Mark K Kenny; JK Karow; MP Cooper; Raichal P Kureekattil; Ian D Hickson; Vilhelm A Bohr
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.
The Journal of biological chemistry 2000;275(31):23500-8.
2000: Amrita Machwe; R Ganunis; Vilhelm A Bohr; David K Orren
Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA.
Nucleic acids research 2000;28(14):2762-70.
2000: A Constantinou; Madalena Tarsounas; JK Karow; Robert M Brosh; Vilhelm A Bohr; Ian D Hickson; Stephen C West
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.
EMBO reports 2000;1(1):80-4.
2000: Robert M Brosh; JK Karow; E J White; N D Shaw; Ian D Hickson; Vilhelm A Bohr
Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.
Nucleic acids research 2000;28(12):2420-30.
2000: Grigory L Dianov; T Thybo; Irina I Dianova; LJ Lipinski; Vilhelm A Bohr
Single nucleotide patch base excision repair is the major pathway for removal of thymine glycol from DNA in human cell extracts.
The Journal of biological chemistry 2000;275(16):11809-13.
2000: MP Cooper; Amrita Machwe; David K Orren; Robert M Brosh; Dale A Ramsden; Vilhelm A Bohr
Ku complex interacts with and stimulates the Werner protein.
Genes & development 2000;14(8):907-12.
2000: Mette Christiansen; Tinna Stevnsner; Vilhelm A Bohr; Brian F C Clark; Suresh Rattan
Gene-specific DNA repair of pyrimidine dimers does not decline during cellular aging in vitro.
Experimental cell research 2000;256(1):308-14.
2000: A May; Vilhelm A Bohr
Gene-specific repair of gamma-ray-induced DNA strand breaks in colon cancer cells: no coupling to transcription and no removal from the mitochondrial genome.
Biochemical and biophysical research communications 2000;269(2):433-7.
2000: Rajendra Prasad; G L Dianov; Vilhelm A Bohr; Samuel H Wilson
FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.
The Journal of biological chemistry 2000;275(6):4460-6.
2000: Peter Ravn; S Kjaer; Kristina H Jensen; Troels Wind; Kim Bak Jensen; Peter Kristensen; Robert M Brosh; David K Orren; Vilhelm A Bohr; Brian F C Clark
Identification of phage antibodies toward the Werner protein by selection on Western blots.
Electrophoresis 2000;21(3):509-16.
2000: Robert Michael Anson; EK Hudson; Vilhelm A Bohr
Mitochondrial endogenous oxidative damage has been overestimated.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(2):355-60.
2000: Adayabalam S Balajee; Luca Proietti de Santis; Robert M Brosh; Rebecca R Selzer; Vilhelm A Bohr
Role of the ATPase domain of the Cockayne syndrome group B protein in UV induced apoptosis.
Oncogene 2000;19(4):477-89.
1999: Adayabalam S Balajee; Irina I Dianova; Vilhelm A Bohr
Oxidative damage-induced PCNA complex formation is efficient in xeroderma pigmentosum group A but reduced in Cockayne syndrome group B cells.
Nucleic acids research 1999;27(22):4476-82.
1999: Rudaina H Alrefai; E J Beecham; Vilhelm A Bohr; Patricia J Gearhart
Less repair of pyrimidine dimers and single-strand breaks in genes by scid cells.
Biochemical and biophysical research communications 1999;264(3):878-82.
1999: Robert M Brosh; Adayabalam S Balajee; Rebecca R Selzer; Morten Sunesen; Luca Proietti de Santis; Vilhelm A Bohr
The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair.
Molecular biology of the cell 1999;10(11):3583-94.
1999: SJ Mazur; K Sakaguchi; E Appella; X W Wang; C C Harris; Vilhelm A Bohr
Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain.
Journal of molecular biology 1999;292(2):241-9.
1999: RH Stierum; Grigory L Dianov; Vilhelm A Bohr
Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts.
Nucleic acids research 1999;27(18):3712-9.
1999: David K Orren; Robert M Brosh; JO Nehlin; Amrita Machwe; Matthew D Gray; Vilhelm A Bohr
Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.
Nucleic acids research 1999;27(17):3557-66.
1999: Grigory L Dianov; B R Jensen; Mark K Kenny; Vilhelm A Bohr
Replication protein A stimulates proliferating cell nuclear antigen-dependent repair of abasic sites in DNA by human cell extracts.
Biochemistry 1999;38(34):11021-5.
1999: Vilhelm A Bohr; Robert Michael Anson
Mitochondrial DNA repair pathways.
Journal of bioenergetics and biomembranes 1999;31(4):391-8.
1999: Robert Michael Anson; S Sentürker; Miral Dizdaroglu; Vilhelm A Bohr
Measurement of oxidatively induced base lesions in liver from Wistar rats of different ages.
Free radical biology & medicine 1999;27(3-4):456-62.
1999: LJ Lipinski; N Hoehr; SJ Mazur; Grigory L Dianov; S Sentürker; Miral Dizdaroglu; Vilhelm A Bohr
Repair of oxidative DNA base lesions induced by fluorescent light is defective in xeroderma pigmentosum group A cells.
Nucleic acids research 1999;27(15):3153-8.
1999: Adayabalam S Balajee; Amrita Machwe; Alfred May; Matthew D Gray; Oshima Junko; George M Martin; JO Nehlin; Robert M Brosh; David K Orren; Vilhelm A Bohr
The Werner syndrome protein is involved in RNA polymerase II transcription.
Molecular biology of the cell 1999;10(8):2655-68.
1999: Deborah L Croteau; RH Stierum; Vilhelm A Bohr
Mitochondrial DNA repair pathways.
Mutation research 1999;434(3):137-48.
1999: MP Cooper; Adayabalam S Balajee; Vilhelm A Bohr
The C-terminal domain of p21 inhibits nucleotide excision repair In vitro and In vivo.
Molecular biology of the cell 1999;10(7):2119-29.
1999: Steen Kølvraa; Claus Bischoff; Vilhelm A Bohr
[Telomere terminals and telomerase. The biological aging clock?].
Ugeskrift for laeger 1999;161(26):3987-91.
1999: Robert M Brosh; David K Orren; JO Nehlin; Peter Ravn; Mark K Kenny; Amrita Machwe; Vilhelm A Bohr
Functional and physical interaction between WRN helicase and human replication protein A.
The Journal of biological chemistry 1999;274(26):18341-50.
1999: Vilhelm A Bohr
[Focusing on the molecular biology of aging].
Ugeskrift for laeger 1999;161(25):3819-22.
1999: Adayabalam S Balajee; Alfred May; Vilhelm A Bohr
DNA repair of pyrimidine dimers and 6-4 photoproducts in the ribosomal DNA.
Nucleic acids research 1999;27(12):2511-20.
1999: C Cullinane; SJ Mazur; J M Essigmann; D R Phillips; Vilhelm A Bohr
Inhibition of RNA polymerase II transcription in human cell extracts by cisplatin DNA damage.
Biochemistry 1999;38(19):6204-12.
1999: Nadja C Souza-Pinto; Deborah L Croteau; EK Hudson; Richard G Hansford; Vilhelm A Bohr
Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria.
Nucleic acids research 1999;27(8):1935-42.
1999: RH Stierum; Deborah L Croteau; Vilhelm A Bohr
Purification and characterization of a mitochondrial thymine glycol endonuclease from rat liver.
The Journal of biological chemistry 1999;274(11):7128-36.
1999: Grigory L Dianov; C Bischoff; Morten Sunesen; Vilhelm A Bohr
Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells.
Nucleic acids research 1999;27(5):1365-8.
1999: L Custer; Barbara Zajc; Jane M Sayer; C Cullinane; D R Phillips; Albert M Cheh; Donald M Jerina; Vilhelm A Bohr; SJ Mazur
Stereospecific differences in repair by human cell extracts of synthesized oligonucleotides containing trans-opened 7,8,9, 10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-dG adduct stereoisomers located within the human K-ras codon 12 sequence.
Biochemistry 1999;38(2):569-81.
1999: Robert Michael Anson; Vilhelm A Bohr
Gene-specific and mitochondrial repair of oxidative DNA damage.
Methods in molecular biology (Clifton, N.J.) 1999;113():257-79.
1999: Vilhelm A Bohr; G L Dianov
Oxidative DNA damage processing in nuclear and mitochondrial DNA.
Biochimie 1999;81(1-2):155-60.
1998: Vilhelm A Bohr; Robert Michael Anson; SJ Mazur; Grigory L Dianov
Oxidative DNA damage processing and changes with aging.
Toxicology letters 1998;102-103():47-52.
1998: Adayabalam S Balajee; Alfred May; Irina I Dianova; Vilhelm A Bohr
Efficient PCNA complex formation is dependent upon both transcription coupled repair and genome overall repair.
Mutation research 1998;409(3):135-46.
1998: Grigory L Dianov; C Bischoff; Jason Piotrowski; Vilhelm A Bohr
Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts.
The Journal of biological chemistry 1998;273(50):33811-6.
1998: EK Hudson; Barbara A Hogue; Nadja C Souza-Pinto; Deborah L Croteau; Robert Michael Anson; Vilhelm A Bohr; Richard G Hansford
Age-associated change in mitochondrial DNA damage.
Free radical research 1998;29(6):573-9.
1998: David B Winter; Patricia J Gearhart; Vilhelm A Bohr
Homogeneous rate of degradation of nuclear DNA during apoptosis.
Nucleic acids research 1998;26(19):4422-5.
1998: Adayabalam S Balajee; Alfred May; Vilhelm A Bohr
Fine structural analysis of DNA repair in mammalian cells.
Mutation research 1998;404(1-2):3-11.
1998: Vilhelm A Bohr; Grigory L Dianov; Adayabalam S Balajee; Alfred May; David K Orren
DNA repair and transcription in human premature aging disorders.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1998;3(1):11-3.
1998: David B Winter; Quy H Phung; Asad Umar; Sean M Baker; RE Tarone; K Tanaka; R Michael Liskay; Thomas A Kunkel; Vilhelm A Bohr; Patricia J Gearhart
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6953-8.
1998: Quy H Phung; David B Winter; A Cranston; RE Tarone; Vilhelm A Bohr; Richard Fishel; Patricia J Gearhart
Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein.
The Journal of experimental medicine 1998;187(11):1745-51.
1998: M Jaiswal; LJ Lipinski; Vilhelm A Bohr; SJ Mazur
Efficient in vitro repair of 7-hydro-8-oxodeoxyguanosine by human cell extracts: involvement of multiple pathways.
Nucleic acids research 1998;26(9):2184-91.
1998: Carleen Cullinane; Vilhelm A Bohr
DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria.
Cancer research 1998;58(7):1400-4.
1998: Robert Michael Anson; Deborah L Croteau; RH Stierum; C Filburn; R Parsell; Vilhelm A Bohr
Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA.
Nucleic acids research 1998;26(2):662-8.
1997: Deborah L Croteau; Colette ApRhys; EK Hudson; Grigory L Dianov; Richard G Hansford; Vilhelm A Bohr
An oxidative damage-specific endonuclease from rat liver mitochondria.
The Journal of biological chemistry 1997;272(43):27338-44.
1997: Deborah L Croteau; Vilhelm A Bohr
Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells.
The Journal of biological chemistry 1997;272(41):25409-12.
1997: David K Orren; L N Petersen; Vilhelm A Bohr
Persistent DNA damage inhibits S-phase and G2 progression, and results in apoptosis.
Molecular biology of the cell 1997;8(6):1129-42.
1997: Adayabalam S Balajee; Alfred May; Grigory L Dianov; Errol C Friedberg; Vilhelm A Bohr
Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4306-11.
1997: Barbara A Gilchrest; Vilhelm A Bohr
Aging processes, DNA damage, and repair.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(5):322-30.
1997: E J Beecham; James D Owens; John D Shaughnessy; Konrad Huppi; Vilhelm A Bohr; J Frederic Mushinski
Decoupling of DNA excision repair and RNA transcription in translocation breaksite regions of plasmacytoma-susceptible BALB/cAnPt mice.
Carcinogenesis 1997;18(4):687-94.
1997: C Cullinane; C A Weber; G Dianov; Vilhelm A Bohr
Restoration of preferential and strand specific gene repair in group 2 Chinese hamster ovary mutants (UV5) by the XPD (ERCC2) gene.
Carcinogenesis 1997;18(4):681-6.
1996: B G Taffe; F Larminat; J Laval; Deborah L Croteau; Robert Michael Anson; Vilhelm A Bohr
Gene-specific nuclear and mitochondrial repair of formamidopyrimidine DNA glycosylase-sensitive sites in Chinese hamster ovary cells.
Mutation research 1996;364(3):183-92.
1996: L N Petersen; E L Mamenta; T Stevnsner; Stephen G Chaney; Vilhelm A Bohr
Increased gene specific repair of cisplatin induced interstrand crosslinks in cisplatin resistant cell lines, and studies on carrier ligand specificity.
Carcinogenesis 1996;17(12):2597-602.
1996: David K Orren; Grigory L Dianov; Vilhelm A Bohr
The human CSB (ERCC6) gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61.
Nucleic acids research 1996;24(17):3317-22.
1996: Z Bartośova; M Pirśel; William C Reinhold; Maryalice Stetler-Stevenson; Maria Zajac-Kaye; A May; ID Horak; Vilhelm A Bohr
Gene-specific repair in human CD4+ lymphocytes reflects transcription and proliferation.
Mutation research 1996;363(3):191-9.
1996: P A Kruk; Adayabalam S Balajee; K S Rao; Vilhelm A Bohr
Telomere reduction and telomerase inactivation during neuronal cell differentiation.
Biochemical and biophysical research communications 1996;224(2):487-92.
1996: A W Ferguson; U Flatow; N J MacDonald; F Larminat; Vilhelm A Bohr; Patricia S Steeg
Increased sensitivity to cisplatin by nm23-transfected tumor cell lines.
Cancer research 1996;56(13):2931-5.
1996: D K Webb; M K Evans; Vilhelm A Bohr
DNA repair fine structure in Werner's syndrome cell lines.
Experimental cell research 1996;224(2):272-8.
1996: M K Evans; K V Chin; Michael M Gottesman; Vilhelm A Bohr
Gene-specific DNA repair and steady state transcription of the MDR1 gene in human tumor cell lines.
Oncogene 1996;12(3):651-8.
1995: L N Petersen; T Stevnsner; Vilhelm A Bohr
DNA repair in a UV resistant Chinese hamster ovary cell line.
Carcinogenesis 1995;16(12):3075-81.
1995: Vilhelm A Bohr
DNA repair fine structure and its relations to genomic instability.
Carcinogenesis 1995;16(12):2885-92.
1995: Vilhelm A Bohr; Robert Michael Anson
DNA damage, mutation and fine structure DNA repair in aging.
Mutation research 1995;338(1-6):25-34.
1995: L N Petersen; David K Orren; Vilhelm A Bohr
Gene-specific and strand-specific DNA repair in the G1 and G2 phases of the cell cycle.
Molecular and cellular biology 1995;15(7):3731-7.
1995: David K Orren; L N Petersen; Vilhelm A Bohr
A UV-responsive G2 checkpoint in rodent cells.
Molecular and cellular biology 1995;15(7):3722-30.
1995: Charles J. Link; M K Evans; J A Cook; RR Muldoon; T Stevnsner; Vilhelm A Bohr
Caffeine inhibits gene-specific repair of UV-induced DNA damage in hamster cells and in human xeroderma pigmentosum group C cells.
Carcinogenesis 1995;16(5):1149-55.
1995: F Larminat; E J Beecham; Charles J. Link; Alfred May; Vilhelm A Bohr
DNA repair in the endogenous and episomal amplified c-myc oncogene loci in human tumor cells.
Oncogene 1995;10(8):1639-45.
1995: Charles J. Link; Vilhelm A Bohr
3"-Azido-3'-deoxythymidine and 2',3'-dideoxycytidine do not inhibit gene-specific DNA repair in hamster cells.
Biochemical and biophysical research communications 1995;208(1):198-203.
1995: Charles J. Link; J H Robbins; Vilhelm A Bohr
Gene specific DNA repair of damage induced in familial Alzheimer disease cells by ultraviolet irradiation or by nitrogen mustard.
Mutation research 1995;336(2):115-21.
1995: P A Kruk; N J Rampino; Vilhelm A Bohr
DNA damage and repair in telomeres: relation to aging.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(1):258-62.
1994: T Stevnsner; R Ding; M Smulson; Vilhelm A Bohr
Inhibition of gene-specific repair of alkylation damage in cells depleted of poly(ADP-ribose) polymerase.
Nucleic acids research 1994;22(22):4620-4.
1994: N J Rampino; Vilhelm A Bohr
Rapid gene-specific repair of cisplatin lesions at the human DUG/DHFR locus comprising the divergent upstream gene and dihydrofolate reductase gene during early G1 phase of the cell cycle assayed by using the exonucleolytic activity of T4 DNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10977-81.
1994: F Larminat; Vilhelm A Bohr
Role of the human ERCC-1 gene in gene-specific repair of cisplatin-induced DNA damage.
Nucleic acids research 1994;22(15):3005-10.
1994: M K Evans; Vilhelm A Bohr
Gene-specific DNA repair of UV-induced cyclobutane pyrimidine dimers in some cancer-prone and premature-aging human syndromes.
Mutation research 1994;314(3):221-31.
1994: E J Beecham; GM Jones; Charles J. Link; Konrad Huppi; Michael Potter; J Frederic Mushinski; Vilhelm A Bohr
DNA repair defects associated with chromosomal translocation breaksite regions.
Molecular and cellular biology 1994;14(2):1204-12.
1993: M K Evans; B G Taffe; C C Harris; Vilhelm A Bohr
DNA strand bias in the repair of the p53 gene in normal human and xeroderma pigmentosum group C fibroblasts.
Cancer research 1993;53(22):5377-81.
1993: K B Lee; R J Parker; Vilhelm A Bohr; T Cornelison; Eddie Reed
Cisplatin sensitivity/resistance in UV repair-deficient Chinese hamster ovary cells of complementation groups 1 and 3.
Carcinogenesis 1993;14(10):2177-80.
1993: T Stevnsner; Vilhelm A Bohr
Studies on the role of topoisomerases in general, gene- and strand-specific DNA repair.
Carcinogenesis 1993;14(9):1841-50.
1993: T Stevnsner; A May; L N Petersen; F Larminat; M Pirsel; Vilhelm A Bohr
Repair of ribosomal RNA genes in hamster cells after UV irradiation, or treatment with cisplatin or alkylating agents.
Carcinogenesis 1993;14(8):1591-6.
1993: W Zhen; M K Evans; C M Haggerty; Vilhelm A Bohr
Deficient gene specific repair of cisplatin-induced lesions in Xeroderma pigmentosum and Fanconi's anemia cell lines.
Carcinogenesis 1993;14(5):919-24.
1993: M K Evans; J H Robbins; M B Ganges; Robert E Tarone; R S Nairn; Vilhelm A Bohr
Gene-specific DNA repair in xeroderma pigmentosum complementation groups A, C, D, and F. Relation to cellular survival and clinical features.
The Journal of biological chemistry 1993;268(7):4839-47.
1993: F Larminat; W Zhen; Vilhelm A Bohr
Gene-specific DNA repair of interstrand cross-links induced by chemotherapeutic agents can be preferential.
The Journal of biological chemistry 1993;268(4):2649-54.
1993: A May; R S Nairn; D S Okumoto; K Wassermann; T Stevnsner; J C Jones; Vilhelm A Bohr
Repair of individual DNA strands in the hamster dihydrofolate reductase gene after treatment with ultraviolet light, alkylating agents, and cisplatin.
The Journal of biological chemistry 1993;268(3):1650-7.
1993: Kazuhiro Nouso; Vilhelm A Bohr; Herman A J Schut; Elizabeth G Snyderwine
Quantitation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline DNA adducts in specific sequences using alkali or uvrABC excinuclease.
Molecular carcinogenesis 1993;7(2):126-34.
1993: M Dabholkar; F Bostick-Bruton; C Weber; Charles E Egwuagu; Vilhelm A Bohr; Eddie Reed
Expression of excision repair genes in non-malignant bone marrow from cancer patients.
Mutation research 1993;293(2):151-60.
1992: K Wassermann; M Pirsel; Vilhelm A Bohr
Overexpression of metallothionein in Chinese hamster ovary cells and its effect on nitrogen mustard-induced cytotoxicity: role of gene-specific damage and repair.
Cancer research 1992;52(24):6853-9.
1992: Charles J. Link; D L Mitchell; R S Nairn; Vilhelm A Bohr
Preferential and strand-specific DNA repair of (6-4) photoproducts detected by a photochemical method in the hamster DHFR gene.
Carcinogenesis 1992;13(11):1975-80.
1992: Susan P LeDoux; Glenn L Wilson; E J Beecham; T Stevnsner; K Wassermann; Vilhelm A Bohr
Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells.
Carcinogenesis 1992;13(11):1967-73.
1992: M Dabholkar; F Bostick-Bruton; C Weber; Vilhelm A Bohr; Charles E Egwuagu; Eddie Reed
ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients.
Journal of the National Cancer Institute 1992;84(19):1512-7.
1992: W Zhen; Charles J. Link; P M O'Connor; Eddie Reed; R Parker; S B Howell; Vilhelm A Bohr
Increased gene-specific repair of cisplatin interstrand cross-links in cisplatin-resistant human ovarian cancer cell lines.
Molecular and cellular biology 1992;12(9):3689-98.
1992: Elizabeth G Snyderwine; Vilhelm A Bohr
Gene- and strand-specific damage and repair in Chinese hamster ovary cells treated with 4-nitroquinoline 1-oxide.
Cancer research 1992;52(15):4183-9.
1991: Patrick M O'Connor; K Wassermann; M Sarang; Ian Magrath; Vilhelm A Bohr; Kurt W Kohn
Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard.
Cancer research 1991;51(24):6550-7.
1991: Vilhelm A Bohr
Gene specific DNA repair.
Carcinogenesis 1991;12(11):1983-92.
1991: Charles J. Link; Richard K Burt; Vilhelm A Bohr
Gene-specific repair of DNA damage induced by UV irradiation and cancer chemotherapeutics.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1991;3(11):427-36.
1991: J C Jones; T Stevnsner; M R Mattern; Vilhelm A Bohr
Effect of specific enzyme inhibitors on replication, total genome DNA repair and on gene-specific DNA repair after UV irradiation in CHO cells.
Mutation research 1991;255(2):155-62.
1991: E J Beecham; J Frederic Mushinski; E Shacter; Michael Potter; Vilhelm A Bohr
DNA repair in the c-myc proto-oncogene locus: possible involvement in susceptibility or resistance to plasmacytoma induction in BALB/c mice.
Molecular and cellular biology 1991;11(6):3095-104.
1991: Richard K Burt; M C Poirier; Charles J. Link; Vilhelm A Bohr
Antineoplastic drug resistance and DNA repair.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1991;2(5):325-34.
1991: J C Jones; W P Zhen; Eddie Reed; R J Parker; Aziz Sancar; Vilhelm A Bohr
Gene-specific formation and repair of cisplatin intrastrand adducts and interstrand cross-links in Chinese hamster ovary cells.
The Journal of biological chemistry 1991;266(11):7101-7.
1991: C C Pettepher; Susan P LeDoux; Vilhelm A Bohr; Glenn L Wilson
Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin.
The Journal of biological chemistry 1991;266(5):3113-7.
1991: Susan P LeDoux; M Thangada; Vilhelm A Bohr; Glenn L Wilson
Heterogeneous repair of methylnitrosourea-induced alkali-labile sites in different DNA sequences.
Cancer research 1991;51(3):775-9.
1991: Vilhelm A Bohr
Gene specific damage and repair after treatment of cells with UV and chemotherapeutical agents.
Advances in experimental medicine and biology 1991;283():225-33.
1990: K Wassermann; Kurt W Kohn; Vilhelm A Bohr
Heterogeneity of nitrogen mustard-induced DNA damage and repair at the level of the gene in Chinese hamster ovary cells.
The Journal of biological chemistry 1990;265(23):13906-13.
1990: Vilhelm A Bohr
DNA repair at the level of the gene: molecular and clinical considerations.
Journal of cancer research and clinical oncology 1990;116(4):384-91.
1990: E J Beecham; J Frederic Mushinski; E Shacter; Michael Potter; Vilhelm A Bohr
DNA repair in the c-myc locus.
Current topics in microbiology and immunology 1990;166():285-91.
1990: R J Parker; Miriam C Poirier; F Bostick-Bruton; J Vionnet; Vilhelm A Bohr; Eddie Reed
Peripheral blood leukocytes as a surrogate marker for cisplatin drug resistance: studies of adduct levels and the repair gene ERCC1.
Basic life sciences 1990;53():251-61.
1989: D C Thomas; D S Okumoto; Aziz Sancar; Vilhelm A Bohr
Preferential DNA repair of (6-4) photoproducts in the dihydrofolate reductase gene of Chinese hamster ovary cells.
The Journal of biological chemistry 1989;264(30):18005-10.
1989: Vilhelm A Bohr; M K Evans; A J Fornace
DNA repair and its pathogenetic implications.
Laboratory investigation; a journal of technical methods and pathology 1989;61(2):143-61.
1988: Vilhelm A Bohr; E H Chu; M van Duin; P C Hanawalt; D S Okumoto
Human repair gene restores normal pattern of preferential DNA repair in repair defective CHO cells.
Nucleic acids research 1988;16(15):7397-403.
1987: Vilhelm A Bohr; David H Phillips; P C Hanawalt
Heterogeneous DNA damage and repair in the mammalian genome.
Cancer research 1987;47(24 Pt 1):6426-36.
1987: D S Okumoto; Vilhelm A Bohr
DNA repair in the metallothionein gene increases with transcriptional activation.
Nucleic acids research 1987;15(23):10021-30.
1987: Vilhelm A Bohr
Preferential DNA repair in active genes.
Danish medical bulletin 1987;34(6):309-20.