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Kurt Bohren

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Genes & Molecular Sequences

Amino Acid Sequence

Physiology

Phenomena

Catalysis

Procedures

Molecular Cloning

Anatomy

Brain

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Co-Publications
Name
30
Gabbay, Kenneth
8
Wermuth, Bendicht
6
Barski, Oleg
4
Ringe, Dagmar
4
Petsko, Gregory
3
Owerbach, David
2
Harrison, David
2
Nadkarni, Varsha
1
BURG, MAURICE
1
Sheikh-Hamad, David
1
Siller-Lopez, Fernando
1
Yeh, Edward
1
Ko, Ben
1
Aguilar-Cordova, Estuardo
1
Brownlee, June

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Publications

TOP 3
Bohren Kurt M; Gabbay Kenneth H; Owerbach David
Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin.
Owerbach David; McKay Eileen M; Yeh Edward T H; Gabbay Kenneth H; Bohren Kurt M
A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation.
Bohren Kurt M; Brownlee June M; Milne Amy C; Gabbay Kenneth H; Harrison David H T
The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism.

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All Publications

2007: Bohren Kurt M; Gabbay Kenneth H; Owerbach David
Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin.
Protein expression and purification 2007;54(2):289-94.
2005: Owerbach David; McKay Eileen M; Yeh Edward T H; Gabbay Kenneth H; Bohren Kurt M
A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation.
Biochemical and biophysical research communications 2005;337(2):517-20.
2005: Bohren Kurt M; Brownlee June M; Milne Amy C; Gabbay Kenneth H; Harrison David H T
The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism.
Biochimica et biophysica acta 2005;1748(2):201-12.
2004: Bohren Kurt M; Nadkarni Varsha; Song Jian H; Gabbay Kenneth H; Owerbach David
A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus.
The Journal of biological chemistry 2004;279(26):27233-8.
2004: Barski Oleg A; Siller-Lopez Fernando; Bohren Kurt M; Gabbay Kenneth H; Aguilar-Cordova Estuardo
Human aldehyde reductase promoter allows simultaneous expression of two genes in opposite directions.
BioTechniques 2004;36(3):382-4, 386, 388.
2000: Bohren K M; Grimshaw C E
The sorbinil trap: a predicted dead-end complex confirms the mechanism of aldose reductase inhibition.
Biochemistry 2000;39(32):9967-74.
1999: Barski O A; Gabbay K H; Bohren K M
Characterization of the human aldehyde reductase gene and promoter.
Genomics 1999;60(2):188-98.
1999: Nadkarni V; Gabbay K H; Bohren K M; Sheikh-Hamad D
Osmotic response element enhancer activity. Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase.
The Journal of biological chemistry 1999;274(29):20185-90.
1999: Burg M B; Peters E M; Bohren K M; Gabbay K H
Factors affecting counteraction by methylamines of urea effects on aldose reductase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6517-22.
1997: Harrison D H; Bohren K M; Petsko G A; Ringe D; Gabbay K H
The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
Biochemistry 1997;36(51):16134-40.
1997: Ko B C; Ruepp B; Bohren K M; Gabbay K H; Chung S S
Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene.
The Journal of biological chemistry 1997;272(26):16431-7.
1997: Ruepp B U; Bohren K M; Gabbay K H
Characterization of an element resembling an androgen response element (ARE) in the human aldose reductase promoter.
Advances in experimental medicine and biology 1997;414():515-9.
1997: Bohren K M; Barski O A; Gabbay K H
Characterization of a novel murine aldo-keto reductase.
Advances in experimental medicine and biology 1997;414():455-64.
1997: Barski O A; Gabbay K H; Bohren K M
Aldehyde reductase. Catalytic mechanism and substrate recognition.
Advances in experimental medicine and biology 1997;414():443-51.
1996: Barski O A; Gabbay K H; Bohren K M
The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity.
Biochemistry 1996;35(45):14276-80.
1996: Ruepp B; Bohren K M; Gabbay K H
Characterization of the osmotic response element of the human aldose reductase gene promoter.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8624-9.
1995: Grimshaw C E; Bohren K M; Lai C J; Gabbay K H
Human aldose reductase: pK of tyrosine 48 reveals the preferred ionization state for catalysis and inhibition.
Biochemistry 1995;34(44):14374-84.
1995: Grimshaw C E; Bohren K M; Lai C J; Gabbay K H
Human aldose reductase: subtle effects revealed by rapid kinetic studies of the C298A mutant enzyme.
Biochemistry 1995;34(44):14366-73.
1995: Grimshaw C E; Bohren K M; Lai C J; Gabbay K H
Human aldose reductase: rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme.
Biochemistry 1995;34(44):14356-65.
1995: Barski O A; Gabbay K H; Grimshaw C E; Bohren K M
Mechanism of human aldehyde reductase: characterization of the active site pocket.
Biochemistry 1995;34(35):11264-75.
1994: Bohren K M; Wermuth B; Harrison D; Ringe D; Petsko G A; Gabbay K H
Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase.
Journal of molecular biology 1994;244(5):659-64.
1994: Ehrig T; Bohren K M; Prendergast F G; Gabbay K H
Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors.
Biochemistry 1994;33(23):7157-65.
1994: Bohren K M; Grimshaw C E; Lai C J; Harrison D H; Ringe D; Petsko G A; Gabbay K H
Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme.
Biochemistry 1994;33(8):2021-32.
1994: Harrison D H; Bohren K M; Ringe D; Petsko G A; Gabbay K H
An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.
Biochemistry 1994;33(8):2011-20.
1993: Wermuth B; Bohren K M; Ernst E
Autocatalytic modification of human carbonyl reductase by 2-oxocarboxylic acids.
FEBS letters 1993;335(2):151-4.
1993: Wang K; Bohren K M; Gabbay K H
Characterization of the human aldose reductase gene promoter.
The Journal of biological chemistry 1993;268(21):16052-8.
1993: Bohren K M; Gabbay K H
Cys298 is responsible for reversible thiol-induced variation in aldose reductase activity.
Advances in experimental medicine and biology 1993;328():267-77.
1992: Bohren K M; Grimshaw C E; Gabbay K H
Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain.
The Journal of biological chemistry 1992;267(29):20965-70.
1992: Wilson D K; Bohren K M; Gabbay K H; Quiocho F A
An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.
Science (New York, N.Y.) 1992;257(5066):81-4.
1991: Bohren K M; Page J L; Shankar R; Henry S P; Gabbay K H
Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262.
The Journal of biological chemistry 1991;266(35):24031-7.
1989: Bohren K M; Bullock B; Wermuth B; Gabbay K H
The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.
The Journal of biological chemistry 1989;264(16):9547-51.
1988: Ehrig T; Bohren K M; Wermuth B; von Wartburg J P
Degradation of aliphatic alcohols by human liver alcohol dehydrogenase: effect of ethanol and pharmacokinetic implications.
Alcoholism, clinical and experimental research 1988;12(6):789-94.
1988: Wermuth B; Bohren K M; Heinemann G; von Wartburg J P; Gabbay K H
Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.
The Journal of biological chemistry 1988;263(31):16185-8.
1987: Bohren K M; von Wartburg J P; Wermuth B
Inactivation of carbonyl reductase from human brain by phenylglyoxal and 2,3-butanedione: a comparison with aldehyde reductase and aldose reductase.
Biochimica et biophysica acta 1987;916(2):185-92.
1987: Bohren K M; von Wartburg J P; Wermuth B
Kinetics of carbonyl reductase from human brain.
The Biochemical journal 1987;244(1):165-71.
1982: Wermuth B; Bürgisser H; Bohren K; von Wartburg J P
Purification and characterization of human-brain aldose reductase.
European journal of biochemistry / FEBS 1982;127(2):279-84.

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