FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Nuggehally Srinivas

Research Profile

Concepts & Ideas

Procedures

Living Beings

Chemicals & Drugs

Physiology

Co-author Network

Publications

TOP 3
Nuggehally R Srinivas
The re-emergence of salting-out association with acetonitrile for modern day bioanalysis.
Nuggehally R Srinivas; Preeti Ahlawat; Jafar Bhasha Shaik
Allometric modeling of ciclesonide, a nonhalogenated glucocorticoid, and its active metabolite, desisobutyrylciclesonide, using animal-derived pharmacokinetic parameters.
Nuggehally R Srinivas
Commentary on: "study of the pharmacokinetic changes of tramadol in diabetic rats" is the handicapped renal pathway in DMIS contributing for the increased bioavailability of tramadol?

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Nuggehally Srinivas (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Nuggehally R Srinivas
The re-emergence of salting-out association with acetonitrile for modern day bioanalysis.
Biomedical chromatography : BMC 2013;27(5):545-7.
2013: Nuggehally R Srinivas; Preeti Ahlawat; Jafar Bhasha Shaik
Allometric modeling of ciclesonide, a nonhalogenated glucocorticoid, and its active metabolite, desisobutyrylciclesonide, using animal-derived pharmacokinetic parameters.
American journal of therapeutics 2013;20(3):261-6.
2013: Nuggehally R Srinivas
Commentary on: "study of the pharmacokinetic changes of tramadol in diabetic rats" is the handicapped renal pathway in DMIS contributing for the increased bioavailability of tramadol?
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 2013;21(1):23.
2012: Nuggehally R Srinivas
Buccal and intranasal lorazepam clinical pharmacokinetics: can it adequately compete with intravenous lorazepam in pediatric care patients?
European journal of clinical pharmacology 2012;68(8):1221-3.
2012: Ming Yao; Nuggehally R Srinivas
Quantification of fexofenadine in biological matrices: a review of bioanalytical methods.
Biomedical chromatography : BMC 2012;26(8):942-61.
2012: Ramesh Mullangi; Kuldeep Sharma; Nuggehally R Srinivas
Review of HPLC methods and HPLC methods with mass spectrometric detection for direct determination of aspirin with its metabolite(s) in various biological matrices.
Biomedical chromatography : BMC 2012;26(8):906-41.
2012: Sandip Dhondiram Gurav; Sherine Jeniffer; Ravindranath Reddy Gilibili; Sanjeev Giri; Ravindra Punde; Nuggehally R Srinivas; Ramesh Mullangi
A strategy for extending the applicability of a validated plasma calibration curve to quantitative measurements in multiple tissue homogenate samples: a case study from a rat tissue distribution study of JI-101, a triple kinase inhibitor.
Biomedical chromatography : BMC 2012;26(4):419-24.
2012: S D Gurav; S Jeniffer; Z Mohd; R R Gilibili; S Giri; R Govindarajan; Nuggehally R Srinivas; Ramesh Mullangi
Pharmacokinetics, tissue distribution and identification of putative metabolites of JI-101 - a novel triple kinase inhibitor in rats.
Arzneimittel-Forschung 2012;62(1):27-34.
2011: Nuggehally R Srinivas
Blonanserin's interesting food-effect observations: is lymphatic transport involved?
European journal of clinical pharmacology 2011;67(9):975-6.
2011: Nuggehally R Srinivas
PK/PD modeling of rabeprazole in CYP2C19 genotypes: consideration of the influence of thio-ether metabolite, CYP3A4, accumulation and CYP2D6 polymorphism may help to better develop and validate the model.
European journal of clinical pharmacology 2011;67(9):965-6.
2011: Sandip Dhondiram Gurav; Sherine Jeniffer; Ravindranath Reddy Gilibili; Sanjeev Giri; Nuggehally R Srinivas; Ramesh Mullangi
Highly sensitive method for the determination of a novel triple kinase inhibitor with anti-cancer activity, JI-101, in rat plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study.
Biomedical chromatography : BMC 2011;25(7):794-800.
2011: Nuggehally R Srinivas
Dealing with matrix effect: should there be a cut-off limit for signal ion suppression in quantitative assay validation?
Biomedical chromatography : BMC 2011;25(6):740-2.
2011: Nuggehally R Srinivas
Incurred sample reanalysis: dilemma in its applicability - should it be practiced for all bioanalytical assays involving single (parent or metabolite) or multiple analytes (parent/metabolite or parent with co-administered drugs)?
Biomedical chromatography : BMC 2011;25(6):737-9.
2011: Nuggehally R Srinivas
The rationality for using prodrug approach in drug discovery programs for new xenobiotics: opportunities and challenges.
European journal of drug metabolism and pharmacokinetics 2011;36(2):49-59.
2011: Nuggehally R Srinivas
Bioanalysis of complex clinical samples - considerations on analytical variability: some thoughts to ponder.
Biomedical chromatography : BMC 2011;25(6):734-6.
2011: Ravindranath Reddy Gilibili; Ramesh Mullangi; Nuggehally R Srinivas
Intravenous prediction of human pharmacokinetic parameters for ketorolac, a non-steroidal anti-inflammatory agent, using allometry approach.
European journal of drug metabolism and pharmacokinetics 2011;36(2):87-93.
2011: Nuggehally R Srinivas
Inclusion of black box warnings in the curriculum: a topic of global significance in patient care and management.
American journal of pharmaceutical education 2011;75(3):57a.
2011: Nuggehally R Srinivas
Pharmacokinetics of tolbutamide in acute renal failure induced by glycerol: speculative thoughts and perspectives.
Drug metabolism and pharmacokinetics 2011;26(2):216-7.
2011: Ramesh Mullangi; Nuggehally R Srinivas
Niacin and its metabolites: role of LC-MS/MS bioanalytical methods and update on clinical pharmacology. An overview.
Biomedical chromatography : BMC 2011;25(1-2):218-37.
2011: Nuggehally R Srinivas; Ramesh Mullangi
An overview of various validated HPLC and LC-MS/MS methods for quantitation of drugs in bile: challenges and considerations.
Biomedical chromatography : BMC 2011;25(1-2):65-81.
2010: J Manjunath Swamy; Narendra Kamath; Anil Kumar Radha Shekar; Nuggehally R Srinivas; Fjalar Kristjansson
Sensitivity enhancement and matrix effect evaluation during summation of multiple transition pairs-case studies of clopidogrel and ramiprilat.
Biomedical chromatography : BMC 2010;24(5):528-34.
2010: Henry John Baptist D'Souza; Balakrishna Pai; Anil Kumar; Radha Shekar; Nuggehally R Srinivas; Fjalar Kristjansson
Influence of number of calibration standards within a defined range on pharmacokinetic disposition-case studies with omeprazole and clopidogrel carboxylic acid.
Biomedical chromatography : BMC 2010;24(5):544-9.
2010: Nuggehally R Srinivas
Altered disposition of drugs in acute renal failure rat models: drug development strategies and perspectives.
Arzneimittel-Forschung 2010;60(12):731-48.
2010: Mani Kandasamy; Krishnanand Tripathy; Sandhya Ravi; Narendra Kamath; Balakrishna Pai; Nuggehally R Srinivas; Fjalar Kristjansson; Saral Thangam
Unsuspected poor metabolizer phenotypes of fluoxetine in bioavailability/bioequivalence studies from an indian population perspective. Retrospective pharmacokinetic data evaluation.
Arzneimittel-Forschung 2010;60(1):12-21.
2010: Mullangi Ramesh; Preeti Ahlawat; Nuggehally R Srinivas
Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives.
Biomedical chromatography : BMC 2010;24(1):104-23.
2009: Nuggehally R Srinivas
Efflux transporter-mediated interactions with atorvastatin--interesting findings with multiple substrates: istradefylline, verapamil, and rifampicin.
Journal of clinical pharmacology 2009;49(12):1492-3.
2009: Nuggehally R Srinivas
Stereoselective renal tubular secretion of cetirizine enantiomers--initial plasma and urine data analysis may hold the key.
Fundamental & clinical pharmacology 2009;23(5):537; author reply 538.
2009: Nuggehally R Srinivas
LC/MS/MS analysis of capsaicin using multiple transition pairs-some view points to ponder.
Biomedical chromatography : BMC 2009;23(10):1129-30.
2009: Nuggehally R Srinivas
Bioanalytical assay validation parameters re-visited: perspectives on stability studies.
Biomedical chromatography : BMC 2009;23(10):1031-3.
2009: Nuggehally R Srinivas
Is there a place for drug combination strategies using clinical pharmacology attributes?--review of current trends in research.
Current clinical pharmacology 2009;4(3):220-8.
2009: Nuggehally R Srinivas
Genetic CYP2C19 polymorphism dependent non-responders to clopidogrel therapy--does structural design, dosing and induction strategies have a role to play?
European journal of drug metabolism and pharmacokinetics 2009;34(3-4):147-50.
2009: Ming Yao; Nuggehally R Srinivas
Bioanalytical methods for the determination of itraconazole and hydroxyitraconazole: overview from clinical pharmacology, pharmacokinetic, pharmacodynamic and metabolism perspectives.
Biomedical chromatography : BMC 2009;23(7):677-91.
2009: Mullangi Ramesh; Ravi Kumar Trivedi; Nuggehally R Srinivas
Torcetrapib for animal and human pharmacokinetic studies: applicability of chiral and achiral methodologies.
Bioanalysis 2009;1(3):619-28.
2009: Nuggehally R Srinivas
Applicability of LC/MS/MS assay for 6-methoxy-2-napthylacetic acid to support the bioequivalence study of nabumetone-comments on the research work of Patel et al. (2008).
Biomedical chromatography : BMC 2009;23(6):674-5.
2009: Nuggehally R Srinivas
Novel 6-hydroxy chroman-based derivatization reagent for HPLC-EC: challenges of 'unsuspected' chirality.
Biomedical chromatography : BMC 2009;23(6):672-3.
2009: Nuggehally R Srinivas
Unsuspected polymorphic metabolism of rupatadine via its primary metabolite, desloratadine.
Primary care respiratory journal : journal of the General Practice Airways Group 2009;18(2):118-9.
2009: Nuggehally R Srinivas
First-in-human assays: excitement and introspection.
Bioanalysis 2009;1(2):263-4.
2009: Nuggehally R Srinivas
Tigecycline and cyclosporine interaction-an interesting case of biliary-excreted drug enhancing the oral bioavailability of cyclosporine.
European journal of clinical pharmacology 2009;65(5):543-4.
2009: Nuggehally R Srinivas
Dodging matrix effects in liquid chromatography tandem mass spectrometric assays--compilation of key learnings and perspectives.
Biomedical chromatography : BMC 2009;23(5):451-4.
2009: Nuggehally R Srinivas; Mullangi Ramesh
Digoxin - a therapeutic agent and mechanistic probe: review of liquid chromatographic mass spectrometric methods and recent nuances in the clinical pharmacology attributes of digoxin.
Bioanalysis 2009;1(1):97-113.
2009: Nuggehally R Srinivas
Substrate-specific pharmacokinetic interaction between endothelin receptor antagonists and phosphodiesterase-5 inhibitors--assembling the clues.
British journal of clinical pharmacology 2009;67(4):475-7.
2009: Nuggehally R Srinivas
Lack of stability of topotecan in heart tissue homogenates: is it an analytical dilemma or a real phenomenon?
Biomedical chromatography : BMC 2009;23(4):447-9.
2009: Nuggehally R Srinivas
Drug-drug interaction studies in preclinical species: should metabolite(s) kinetics be studied?
Xenobiotica; the fate of foreign compounds in biological systems 2009;39(3):193-6.
2009: Nuggehally R Srinivas
Unsuspected and paradoxical potential for drug interaction by rifampin: things to ponder with antiretroviral therapy.
The Journal of infectious diseases 2009;199(5):766-7; author reply 767.
2009: Nuggehally R Srinivas
Hyperthermic intraperitoneal perfusion chemotherapy--views on the observed variability in oxaliplatin pharmacokinetics.
European journal of clinical pharmacology 2009;65(3):321-2.
2009: Nuggehally R Srinivas
Sensitivity enhancement in tandem liquid chromatographic mass spectrometric assays by summation of two transition ion pairs--perspectives.
Journal of separation science 2009;32(4):483-6.
2009: Nuggehally R Srinivas
Reversal in elution order in liquid chromatography-compilation of experimental observations.
Biomedical chromatography : BMC 2009;23(2):222-3.
2009: Nuggehally R Srinivas; Preeti Ahlawat
Prediction of human pharmacokinetic parameters using animal data and principles of allometry. A case using bicifadine, a non-narcotic analgesic, as an example.
Arzneimittel-Forschung 2009;59(12):625-30.
2009: Nuggehally R Srinivas
Antacid use and reduced bioavailability of oral drugs. Case studies, overview and perspectives.
Arzneimittel-Forschung 2009;59(7):327-34.
2009: Preeti Ahlawat; Nuggehally R Srinivas
Allometric scaling of a metabolically complex camptothecin analog: differences in scaling of irinotecan and its active metabolite, SN-38.
Arzneimittel-Forschung 2009;59(6):311-7.
2009: Nuggehally R Srinivas
Dihydroartemisinin pharmacokinetics in patients with malaria after multiple doses--assembling clues and perspectives.
Drug metabolism and pharmacokinetics 2009;24(3):282-4.
2009: Nuggehally R Srinivas
Considerations for metabolite pharmacokinetic data in bioavailability/bioequivalence assessments. Overview of the recent trends.
Arzneimittel-Forschung 2009;59(4):155-65.
2009: Ramesh Mullangi; Preeti Ahlawat; Ravi K Trivedi; Nuggehally R Srinivas
Use of bile correction factors for allometric prediction of human pharmacokinetic parameters of torcetrapib, a facile cholesteryl ester transfer protein inhibitor.
European journal of drug metabolism and pharmacokinetics 2009;34(1):57-63.
2009: Nuggehally R Srinivas
Rationale for faster oral delivery to overcome the pathophysiology associated with dental pain--biopharmaceutic and pharmacokinetic challenges.
European journal of drug metabolism and pharmacokinetics 2009;34(1):7-10.
2009: Nuggehally R Srinivas
Pharmacokinetic screening strategy for discovery work-use of rodent species: lessons learnt and probing newer thoughts.
Drug metabolism and pharmacokinetics 2009;24(2):197-8.
2009: Nuggehally R Srinivas
Suspected differential interactions of digoxin with imidafenacin and propantheline; some thoughts for introspection.
Drug metabolism and pharmacokinetics 2009;24(2):194-6.
2009: Nuggehally R Srinivas
The emerging technique, microextraction in packed syringes in separation science--can it eliminate matrix effects and fit with LC/MS/MS strategy?
Journal of separation science 2009;32(2):165-6.
2009: Nuggehally R Srinivas
Structurally modified 'dietary flavonoids': are these viable drug candidates for chemoprevention?
Current clinical pharmacology 2009;4(1):67-70.
2008: Nuggehally R Srinivas
Single-dose pharmacokinetic interaction between artesunate and amodiaquine: assembling the clues for the purported interaction.
European journal of clinical pharmacology 2008;64(12):1231-3.
2008: P Ahlawat; Nuggehally R Srinivas
Interspecies scaling of a camptothecin analogue: human predictions for intravenous topotecan using animal data.
Xenobiotica; the fate of foreign compounds in biological systems 2008;38(11):1377-85.
2008: Nuggehally R Srinivas
Applicability of nonlinear calibration regression for quantitative determination of parent and metabolite(s) in bioequivalence assessment.
Biomedical chromatography : BMC 2008;22(11):1315-7.
2008: Nuggehally R Srinivas
Dual drug interactions via P-glycoprotein (P-gp)/ cytochrome P450 (CYP3A4) interplay: recent case study of oral atorvastatin and verapamil.
European journal of clinical pharmacology 2008;64(11):1135-6.
2008: Nuggehally R Srinivas
Assessment of bioequivalence of drug racemates: what are the cues from a bioanalytical perspective-stereoselective vs nonstereoselective?
Biomedical chromatography : BMC 2008;22(11):1318-20.
2008: Venkata V Pavan Kumar; Nuggehally R Srinivas
Application of allometry principles for the prediction of human pharmacokinetic parameters for irbesartan, a AT1 receptor antagonist, from animal data.
European journal of drug metabolism and pharmacokinetics 2008;33(4):247-52.
2008: Nuggehally R Srinivas
The drug-drug interaction potential of rifampicin.
Clinical therapeutics 2008;30(10):1932-3.
2008: Akshanth Reddy Polepally; Venkata V Pavan Kumar; Ravikanth Bhamidipati; Jagannath Kota; Shaik Abdul Naveed; Karnati Harinder Reddy; Rao N V S Mamidi; Natesan Selvakumar; Ramesh Mullangi; Nuggehally R Srinivas
Assessing the issue of instability due to Michael adduct formation in novel chemical entities possessing a carbon-carbon double bond during early drug development--applicability of common laboratory analytical protocols.
Biomedical chromatography : BMC 2008;22(9):960-76.
2008: Preeti Ahlawat; Nuggehally R Srinivas
Allometric prediction of the human pharmacokinetic parameters for naveglitazar.
European journal of drug metabolism and pharmacokinetics 2008;33(3):187-90.
2008: Buddhadev Layek; T Santosh Kumar; Ravi Kumar Trivedi; Ramesh Mullangi; Nuggehally R Srinivas
Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of rhein in human plasma: application to a pharmacokinetic study.
Biomedical chromatography : BMC 2008;22(6):616-24.
2008: Ravi Kumar Trivedi; Pramod Kumar Dubey; Ramesh Mullangi; Nuggehally R Srinivas
Development and validation of a sensitive LC-MS/MS method with electrospray ionization using multiple ions for quantitation of torcetrapib in hamster and dog plasma.
Biomedical chromatography : BMC 2008;22(3):316-26.
2008: Nuggehally R Srinivas
Changing need for bioanalysis during drug development.
Biomedical chromatography : BMC 2008;22(3):235-43.
2008: Chakradhar Lagishetty; Raja Reddy Kallem; Arumugam Karthik; Bala Tripura Sundari; Srirangam Ramesh; Ramesh Mullangi; Nuggehally R Srinivas
A rapid and highly sensitive method for the determination of glimepiride in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a pre-clinical pharmacokinetic study.
Biomedical chromatography : BMC 2008;22(1):58-63.
2007: Ravi Kumar Trivedi; Buddhadev Layek; T Santosh Kumar; Shivva Vittal; Ramesh Ganneboina; P K Dubey; Ramesh Mullangi; Nuggehally R Srinivas
Chiral bioanalysis of torcetrapib enantiomers in hamster plasma by normal-phase liquid chromatography and detection by atmospheric pressure chemical ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;860(2):227-34.
2007: P Venkatesh; T Harisudhan; Hira Choudhury; Ramesh Mullangi; Nuggehally R Srinivas
Pharmacokinetics of etoposide in rats with uranyl nitrate (UN)-induced acute renal failure (ARF): optimization of the duration of UN dosing.
European journal of drug metabolism and pharmacokinetics 2007;32(4):189-96.
2007: Ravi Kumar Trivedi; P K Dubey; Ramesh Mullangi; Nuggehally R Srinivas
Development and validation of an enantioselective HPLC-UV method using Chiralpak AD-H to quantify (+)- and (-)-torcetrapib enantiomers in hamster plasma--application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;857(2):224-30.
2007: Jafar Sadik Basha Shaik; Shaik Abdul Naveed; Nirbhay Kumar Tiwari; Dhanya Shashikumar; Syed Muzeeb; Thammera Ranjith Kumar; Nyavanandi Vijay Kumar; Nadipalli Prabhakar Rao; Nanduri Srinivas; Ramesh Mullangi; Nuggehally R Srinivas
Concurrent determination of ezetimibe and its phase-I and II metabolites by HPLC with UV detection: quantitative application to various in vitro metabolic stability studies and for qualitative estimation in bile.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;853(1-2):88-96.
2007: Raja Reddy Kallem; Arumugam Karthik; Chakradhar Lagishetty; Ramesh Mullangi; Nuggehally R Srinivas
Development and validation of a highly sensitive and robust LC-MS/MS with electrospray ionization method for quantification of rosuvastatin in small volume human plasma samples and its application to a clinical study.
Arzneimittel-Forschung 2007;57(11):705-11.
2007: Venkata V Pavankuamr; C A Vinu; Ramesh Mullangi; Nuggehally R Srinivas
Preclinical pharmacokinetics and interspecies scaling of ragaglitazar, a novel biliary excreted PPAR dual activator.
European journal of drug metabolism and pharmacokinetics 2007;32(1):29-37.
2007: Ming Yao; Arun Swaminathan; Nuggehally R Srinivas
Assessment of dose proportionality of muraglitazar after repeated oral dosing in rats via a sparse sampling methodology.
Biopharmaceutics & drug disposition 2007;28(1):35-42.
2006: S Mustafa; P Venkatesh; K Pasha; Ramesh Mullangi; Nuggehally R Srinivas
Altered intravenous pharmacokinetics of topotecan in rats with acute renal failure (ARF) induced by uranyl nitrate: do adenosine A1 antagonists (selective/non-selective) normalize the altered topotecan kinetics in ARF?
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(12):1239-58.
2006: Raja Reddy Kallem; Ravi Kumar Trivedi; Ramesh Mullangi; Nuggehally R Srinivas
Validation of a simple HPLC method for DRF-4848, a novel COX-2 inhibitor suitable for pharmacokinetic application in rats.
Biomedical chromatography : BMC 2006;20(12):1289-94.
2006: Shivva Vittal; Nikhil R Shitut; Thammera Ranjith Kumar; Menon C A Vinu; Ramesh Mullangi; Nuggehally R Srinivas
Simultaneous quantitation of rosuvastatin and gemfibrozil in human plasma by high-performance liquid chromatography and its application to a pharmacokinetic study.
Biomedical chromatography : BMC 2006;20(11):1252-9.
2006: Syed Muzeeb; Jafar Sadik Basha Shaik; Dhanya Shashikumar; Ramesh Mullangi; Nuggehally R Srinivas
Glucuronidation of DRF-6574, hydroxy metabolite of DRF-4367 (a novel COX-2 inhibitor) by pooled human liver, intestinal microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT1A1, 1A3 and 1A8.
European journal of drug metabolism and pharmacokinetics 2006;31(4):299-309.
2006: P Venkatesh; T Harisudhan; Hira Choudhury; Ramesh Mullangi; Nuggehally R Srinivas
Simultaneous estimation of six anti-diabetic drugs--glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of pharmaceutical formulations and its application to human plasma assay.
Biomedical chromatography : BMC 2006;20(10):1043-8.
2006: Ming Yao; Nuggehally R Srinivas
Liquid chromatography/mass spectrometry for the quantitation of muraglitazar in monkey plasma.
Biomedical chromatography : BMC 2006;20(10):1017-23.
2006: Syed Muzeeb; P Venkatesh; Ramesh Mullangi; Nuggehally R Srinivas
Influence of cholestyramine on the pharmacokinetics of rosiglitazone and its metabolite, desmethylrosiglitazone, after oral and intravenous dosing of rosiglitazone: impact on oral bioavailability, absorption, and metabolic disposition in rats.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(9):838-56.
2006: Chandrasekar Nirmala; Ravikumar Trivedi; Penubaka Venkata Prasanthi; Ramesh Mullangi; Nuggehally R Srinivas
Development and validation of a sensitive ELISA for quantitation of Grastim (rhG-CSF) in rat plasma: Application to a pharmacokinetic study.
Biomedical chromatography : BMC 2006;20(9):945-50.
2006: Thammera Ranjith Kumar; Nikhil R Shitut; Pasikanti Kishore Kumar; Menon C A Vinu; Venkata V Pavan Kumar; Ramesh Mullangi; Nuggehally R Srinivas
Determination of rosuvastatin in rat plasma by HPLC: Validation and its application to pharmacokinetic studies.
Biomedical chromatography : BMC 2006;20(9):881-7.
2006: Nuggehally R Srinivas
Drug disposition of chiral and achiral drug substrates metabolized by cytochrome P450 2D6 isozyme: case studies, analytical perspectives and developmental implications.
Biomedical chromatography : BMC 2006;20(6-7):466-91.
2006: Nuggehally R Srinivas
Applicability of bioanalysis of multiple analytes in drug discovery and development: review of select case studies including assay development considerations.
Biomedical chromatography : BMC 2006;20(5):383-414.
2006: Sonia Chawla; Soma Ghosh; Vaibhav Sihorkar; Ranjani Nellore; T R Shantha Kumar; Nuggehally R Srinivas
High-performance liquid chromatography method development and validation for simultaneous determination of five model compounds, antipyrine, metoprolol, ketoprofen, furosemide and phenol red, as a tool for the standardization of rat in situ intestinal permeability studies using timed wavelength detection.
Biomedical chromatography : BMC 2006;20(4):349-57.
2006: Md Khalid Pasha; Syed Muzeeb; Jafar Sadik Basha Shaik; Dhanya Shashikumar; Ramesh Mullangi; Nuggehally R Srinivas
Analysis of five HMG-CoA reductase inhibitors-- atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies.
Biomedical chromatography : BMC 2006;20(3):282-93.
2006: S Basavaraj; Vaibhav Sihorkar; T R Shantha Kumar; Prakash Sundaramurthi; Nuggehally R Srinivas; P Venkatesh; Mullangi Ramesh; Sunil Kumar Singh
Bioavailability enhancement of poorly water soluble and weakly acidic new chemical entity with 2-hydroxy propyl-beta-cyclodextrin: selection of meglumine, a polyhydroxy base, as a novel ternary component.
Pharmaceutical development and technology 2006;11(4):443-51.
2006: Venkata V Pavan Kumar; Menon C A Vinu; Addepalli V Ramani; Ramesh Mullangi; Nuggehally R Srinivas
Simultaneous quantitation of etoricoxib, salicylic acid, valdecoxib, ketoprofen, nimesulide and celecoxib in plasma by high-performance liquid chromatography with UV detection.
Biomedical chromatography : BMC 2006;20(1):125-32.
2005: Ravi Kumar Trivedi; Raja Reddy Kallem; Ramesh Mullangi; Nuggehally R Srinivas
Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a clinical study.
Journal of pharmaceutical and biomedical analysis 2005;39(3-4):661-9.
2005: Syed Muzeeb; M K Pasha; Jafar Sadik Basha Shaik; Ramesh Mullangi; Nuggehally R Srinivas
Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(8):825-38.
2005: Ravikanth Bhamidipati; P Venkatesh; Prajakta V Dravid; Prasad C Narasimhulu; Sastry Tvrs; Jagattaran Das; Ramesh Mullangi; Nuggehally R Srinivas
Assessment of oral bioavailability and preclinical pharmacokinetics of DRF-6196, a novel oxazolidinone analogue, in comparison to linezolid.
European journal of drug metabolism and pharmacokinetics 2005;30(3):187-93.
2005: T R Shantha Kumar; Sonia Chawla; Satish K Nachaegari; Sunil Kumar Singh; Nuggehally R Srinivas
Validated HPLC analytical method with programmed wavelength UV detection for simultaneous determination of DRF-4367 and Phenol red in rat in situ intestinal perfusion study.
Journal of pharmaceutical and biomedical analysis 2005;38(1):173-9.
2005: Arani Chatterjee; Raghunadharao Digumarti; Kasiram Katneni; Vijay V Upreti; Rao N V S Mamidi; Ramesh Mullangi; Anjna Surath; Maddali L Srinivas; Srihari Uppalapati; Sangeeta Jiwatani; Nuggehally R Srinivas
Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory cancer patients in a bridging phase I study.
Journal of clinical pharmacology 2005;45(4):453-60.
2005: Ravikanth Bhamidipati; S Mujeeb; Prajakta V Dravid; A A Khan; Sunil K Singh; Y Koteswar Rao; Ramesh Mullangi; Nuggehally R Srinivas
Pre-clinical assessment of DRF 4367, a novel COX-2 inhibitor: evaluation of pharmacokinetics, absolute oral bioavailability and metabolism in mice and comparative inter-species in vitro metabolism.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(3):253-71.
2005: Prajakta V Dravid; Ravikanth Bhamidipati; Ramesh Mullangi; Nuggehally R Srinivas
Validation of a simple bioanalytical method for the determination of DRF-6196, a novel oxazolidinone, in mouse plasma: application to a single-dose pharmacokinetic study.
Arzneimittel-Forschung 2005;55(4):239-44.
2005: Donglu Zhang; Rajesh Krishna; Lifei Wang; Jianing Zeng; James Mitroka; Renke Dai; Narayanan Narasimhan; Richard A Reeves; Nuggehally R Srinivas; Lewis J Klunk
Metabolism, pharmacokinetics, and protein covalent binding of radiolabeled MaxiPost (BMS-204352) in humans.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(1):83-93.
2004: Nuggehally R Srinivas
Simultaneous chiral analyses of multiple analytes: case studies, implications and method development considerations.
Biomedical chromatography : BMC 2004;18(10):759-84.
2004: Jianing Zeng; Holly Palme; Nuggehally R Srinivas; Mark Arnold
Determination of a neuroprotective agent (S)-(+)-BMS-204352 in human, rat and dog plasma by enantioselective liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;811(2):109-17.
2004: Ravi Kumar Trivedi; Raja Reddy Kallem; Rao N V S Mamidi; Ramesh Mullangi; Nuggehally R Srinivas
Determination of lipoic acid in rat plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a pharamcokinetic study.
Biomedical chromatography : BMC 2004;18(9):681-6.
2004: Ramesh Mullangi; Raja Reddy Kallem; Ravikanth Bhamidipati; Rao N V S Mamidi; Nuggehally R Srinivas
HPLC method for determination of DRF-4367 in rat plasma: validation and its application to pharmacokinetics in Wistar rats.
Biomedical chromatography : BMC 2004;18(8):576-80.
2004: Kota Jagannath; Madhusudana Rao Chaluvadi; Ramesh Mullangi; N V S Rao Mamidi; Nuggehally R Srinivas
Intravenous pharmacokinetics, oral bioavailability and dose proportionality of ragaglitazar, a novel PPAR-dual activator in rats.
Biopharmaceutics & drug disposition 2004;25(7):323-8.
2004: S Syed Mustafa; Ravikumar Trivedi; N V S Rao Mamidi; Ramesh Mullangi; Nuggehally R Srinivas
Development and validation of a chiral liquid chromatographic method, based on Chiralpak to quantify enantiomers of (+/-)-DRF 2725 in rat plasma: lack of inversion of ragaglitazar (S(-)-DRF 2725) to its antipode in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;809(1):23-30.
2004: Nuggehally R Srinivas
Clinical pharmacokinetic data of racemic drugs obtained by the indirect method following precolumn diastereomer formation: is the influence of racemization during chiral derivatization significant?
Biomedical chromatography : BMC 2004;18(6):343-9.
2004: Arani Chatterjee; Raghunadharao Digumarti; Rao N V S Mamidi; Kasiram Katneni; Vijay V Upreti; Anjna Surath; Maddali L Srinivas; Srihari Uppalapati; Sangeeta Jiwatani; Swaminathan Subramaniam; Nuggehally R Srinivas
Safety, tolerability, pharmacokinetics, and pharmacodynamics of an orally active novel camptothecin analog, DRF-1042, in refractory cancer patients in a phase I dose escalation study.
Journal of clinical pharmacology 2004;44(7):723-36.
2004: Ravikanth Bhamidipati; Prajakta V Dravid; Ramesh Mullangi; Nuggehally R Srinivas
Prediction of clinical pharmacokinetic parameters of linezolid using animal data by allometric scaling: applicability for the development of novel oxazolidinones.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(6):571-9.
2004: Nuggehally R Srinivas
Evaluation of experimental strategies for the development of chiral chromatographic methods based on diastereomer formation.
Biomedical chromatography : BMC 2004;18(4):207-33.
2004: Nuggehally R Srinivas
Role of stereoselective assays in bioequivalence studies of racemic drugs: have we reached a consensus?
Journal of clinical pharmacology 2004;44(2):115-9.
2003: M N V S Rao; B Biju; A K Ansar; S Mujeeb; Mullangi Ramesh; Nuggehally R Srinivas
'Open access' generic method for continuous determination of major human CYP450 probe substrates/metabolites and its application in drug metabolism studies.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(12):1233-45.
2003: Ramesh Mullangi; Ming Yao; Nuggehally R Srinivas
Resolution of enantiomers of ketoprofen by HPLC: a review.
Biomedical chromatography : BMC 2003;17(7):423-34.
2003: Rao N V S Mamidi; Biju Benjamin; Mullangi Ramesh; Nuggehally R Srinivas
Simple method for the determination of rosiglitazone in human plasma using a commercially available internal standard.
Biomedical chromatography : BMC 2003;17(6):417-20.
2003: Vijay V Upreti; Rao N V S Mamidi; Kasiram Katneni; Nuggehally R Srinivas
Quantitative determination of DRF-1042 in human plasma by HPLC: validation and application in clinical pharmacokinetics.
Biomedical chromatography : BMC 2003;17(6):385-90.
2003: Nuggehally R Srinivas; Rao N V S Mamidi
Bioanalytical considerations for compounds containing free sulfhydryl groups.
Biomedical chromatography : BMC 2003;17(5):285-91.
2003: Mullangi Ramesh; Rao N V S Mamidi; Kota Jagannath; Sunil Kumar Singh; Kalleda Srinivasa Rao; Y Koteswar Rao; Casturi Seshagirirao; Ramanujam Rajagopalan; Nuggehally R Srinivas
Oral bioavailability and pharmacokinetics of DRF-4367, a new COX-2 inhibitor in rats.
European journal of drug metabolism and pharmacokinetics 2003;28(2):137-41.
2002: Rao N V S Mamidi; Ramesh Mullangi; Jagannath Kota; Ravikanth Bhamidipati; Ansar A Khan; Kasiram Katneni; Srinivasa Datla; Sunil K Singh; Koteswar Y Rao; C Seshagiri Rao; Nuggehally R Srinivas; Ramanujam Rajagopalan
Pharmacological and pharmacokinetic evaluation of celecoxib prodrugs in rats.
Biopharmaceutics & drug disposition 2002;23(7):273-82.
2002: Rajesh Krishna; Vinod R Shah; Nuggehally R Srinivas
Pharmacokinetics and dose proportionality of BMS-204352 after intraarterial administration to rats.
Biopharmaceutics & drug disposition 2002;23(6):233-7.
2002: Rajesh Krishna; Holly Palme; Jianing Zeng; Nuggehally R Srinivas
Effect of dose and input rate on the brain penetration of BMS-204352 following intravenous administration to rats.
Biopharmaceutics & drug disposition 2002;23(6):227-31.
2002: Mamidi N V S Rao; Ramesh Mullangi; Kasiram Katneni; Bhamidipati Ravikanth; Aravind P Babu; Usha P Rani; M U R Naidu; Nuggehally R Srinivas; Ramanujam Rajagopalan
Lack of effect of sucralfate on the absorption and pharmacokinetics of rosiglitazone.
Journal of clinical pharmacology 2002;42(6):670-5.
2002: Ming Yao; Subbaro Mantha; Vinod R Shah; Nimish N Vachharajani; Mark E Arnold; Janice M Pursley; Nuggehally R Srinivas
High performance liquid chromatographic-mass spectrometric assay for the quantitation of BMS-204352 in dog K(3)EDTA plasma.
Biomedical chromatography : BMC 2002;16(3):175-82.
2002: Rajesh Krishna; Vinod R Shah; Subbaro Mantha; Nimish N Vachharajani; Nuggehally R Srinivas
Pharmacokinetics and dose proportionality of BMS-204352 after intravenous administration to dogs.
Biopharmaceutics & drug disposition 2002;23(2):83-6.
2002: Rajesh Krishna; Ming Yao; Nuggehally R Srinivas; Vinod Shah; Janice M Pursley; Mark Arnold; Nimish N Vachharajani
Disposition of radiolabeled BMS-204352 in rats and dogs.
Biopharmaceutics & drug disposition 2002;23(1):41-6.
2001: Nuggehally R Srinivas; RH Barbhaiya; K K Midha
Enantiomeric drug development: issues, considerations, and regulatory requirements.
Journal of pharmaceutical sciences 2001;90(9):1205-15.
2001: Ming Yao; L Chen; Nuggehally R Srinivas
Quantitation of itraconazole in rat heparinized plasma by liquid chromatography-mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2001;752(1):9-16.
2001: Rajesh Krishna; M Yao; D Kaczor; Nimish N Vachharajani; Nuggehally R Srinivas
In vitro protein binding studies with BMS-204352: lack of protein binding displacement interaction in human serum.
Biopharmaceutics & drug disposition 2001;22(1):41-4.
2000: Ming Yao; Nuggehally R Srinivas
Simultaneous quantitation of d7-nefazodone, nefazodone, d7-hydroxynefazodone, hydroxynefazodone, m-chlorophenylpiperazine and triazole-dione in human plasma by liquid chromatographic-mass spectrometry.
Biomedical chromatography : BMC 2000;14(2):106-12.
1999: Nuggehally R Srinivas; W C Shyu
Single dose and multiple dose pharmacokinetics of 2'-fluoro-2',3'-dideoxyadenosine and 2'-fluoro-2',3'-dideoxyinosine, anti-HIV agents, in rats.
European journal of drug metabolism and pharmacokinetics 1999;24(4):329-34.
1999: S Y Chang; D Whigan; W C Shyu; Nuggehally R Srinivas
Sensitive triple-quadrupole mass spectrometric assay for the determination of BMS-181885, a 5-HT1 agonist, in human plasma following solid phase extraction.
Biomedical chromatography : BMC 1999;13(6):425-30.
1998: Ming Yao; Vinod R Shah; Wen Chyi Shyu; Nuggehally R Srinivas
Sensitive liquid chromatographic-mass spectrometric assay for the simultaneous quantitation of nefazodone and its metabolites hydroxynefazodone m-chlorophenylpiperazine and triazole-dione in human plasma using single-ion monitoring.
Journal of chromatography. B, Biomedical sciences and applications 1998;718(1):77-85.
1998: Nuggehally R Srinivas; W C Shyu; C W Soong; D Greene
Absolute bioavailability and dose proportionality of BMS-181885, an antimigraine agent, following the administration of single intranasal doses to cynomolgus monkeys.
Journal of pharmaceutical sciences 1998;87(9):1170-2.
1998: Nuggehally R Srinivas; Vinod R Shah; A Schuster; X Jiang; D W Whigan; Wen Chyi Shyu
High-performance liquid chromatographic-electrochemical assay for the quantitation of BMS-181885 in monkey plasma.
Journal of chromatography. B, Biomedical sciences and applications 1998;705(2):317-22.
1997: Nuggehally R Srinivas; Wen Chyi Shyu; C Gleason; A Schuster; DS Greene; RH Barbhaiya
Effects of age, gender, and diurnal variation on the steady-state pharmacokinetics of BMS-181101, an antidepressant, in healthy subjects.
Clinical pharmacology and therapeutics 1997;62(4):408-16.
1997: Nuggehally R Srinivas; Wen Chyi Shyu; J Lee; DS Greene; RH Barbhaiya
Lack of effect of food on the steady state pharmacokinetics of BMS-181101, an antidepressant, in healthy subjects.
Biopharmaceutics & drug disposition 1997;18(7):585-93.
1997: Nuggehally R Srinivas; Wen Chyi Shyu; R S Weiner; G Warner; C Comereski; Lee K Tay; DS Greene; RH Barbhaiya
Assessment of dose proportionality, absolute bioavailability, and immunogenicity response of CTLA4Ig (BMS-188667), a novel immunosuppressive agent, following subcutaneous and intravenous administration to rats.
Pharmaceutical research 1997;14(7):911-6.
1997: R S Weiner; Nuggehally R Srinivas; J D Calore; C G Fadrowski; Wen Chyi Shyu; Lee K Tay
A sensitive enzyme immunoassay for the quantitation of human CTLA4Ig fusion protein in mouse serum: pharmacokinetic application to optimizing cell line selection.
Journal of pharmaceutical and biomedical analysis 1997;15(5):571-9.
1996: S Kaul; Nuggehally R Srinivas; V Mummaneni; L N Igwemezie; RH Barbhaiya
Effects of gender, age, and race on the pharmacokinetics of etoposide after intravenous administration of etoposide phosphate in cancer patients.
Seminars in oncology 1996;23(6 Suppl 13):23-9.
1996: S Kaul; Nuggehally R Srinivas; L N Igwemezie; RH Barbhaiya
A pharmacodynamic evaluation of hematologic toxicity observed with etoposide phosphate in the treatment of cancer patients.
Seminars in oncology 1996;23(6 Suppl 13):15-22.
1996: D A Campbell; Vinod R Shah; Nuggehally R Srinivas; Wen Chyi Shyu
High-performance liquid chromatographic analysis of 2'-fluoro-2',3'-dideoxyadenosine and 2'-fluoro-2',3'-dideoxyinosine in dog plasma and urine.
Journal of pharmaceutical sciences 1996;85(8):890-2.
1996: Vinod R Shah; Nuggehally R Srinivas; D A Campbell; S Mantha; G Duncan; A Schuster; D W Whigan; Wen Chyi Shyu
High-performance liquid chromatographic-ultraviolet assay for the simultaneous quantitation of BMS-181101 and its putative hydroxy metabolites in rat and monkey plasma.
Biomedical chromatography : BMC 1996;10(3):135-8.
1996: Nuggehally R Srinivas; C A Knupp; B Batteiger; R A Smith; RH Barbhaiya
A pharmacokinetic interaction study of didanosine coadministered with trimethoprim and/or sulphamethoxazole in HIV seropositive asymptomatic male patients.
British journal of clinical pharmacology 1996;41(3):207-15.
1996: Nuggehally R Srinivas; W H Barr; Wen Chyi Shyu; E Mohandoss; S Chow; J Staggers; G Balan; FJ Belas; Ian A Blair; RH Barbhaiya
Bioequivalence of two tablet formulations of nadolol using single and multiple dose data: assessment using stereospecific and nonstereospecific assays.
Journal of pharmaceutical sciences 1996;85(3):299-303.
1996: Nuggehally R Srinivas; R S Weiner; Wen Chyi Shyu; J D Calore; D Tritschler; Lee K Tay; J S Lee; DS Greene; RH Barbhaiya
A pharmacokinetic study of intravenous CTLA4Ig, a novel immunosuppressive agent, in mice.
Journal of pharmaceutical sciences 1996;85(3):296-8.
1996: Nuggehally R Srinivas; R S Weiner; G Warner; Wen Chyi Shyu; T Davidson; C G Fadrowski; Lee K Tay; J S Lee; DS Greene; RH Barbhaiya
Pharmacokinetics and pharmacodynamics of CTLA4lg (BMS-188667), a novel immunosuppressive agent, in monkeys following multiple doses.
Journal of pharmaceutical sciences 1996;85(1):1-4.
1996: F A Stancato; Nuggehally R Srinivas; C A Knupp
Effect of temperature on the high-performance liquid chromatographic separation of the anti-HIV agents, didanosine and stavudine.
Biomedical chromatography : BMC 1996;10(1):29-31.
1995: Nuggehally R Srinivas; Wen Chyi Shyu; R S Weiner; Lee K Tay; DS Greene; RH Barbhaiya
Pharmacokinetics of CTLA4Ig (BMS-188667), a novel immunosuppressive agent, following intravenous and subcutaneous administration to mice.
Journal of pharmaceutical sciences 1995;84(12):1488-9.
1995: Nuggehally R Srinivas; Wen Chyi Shyu; Vinod R Shah; D A Campbell; RH Barbhaiya
Stereoselective analysis of nadolol in human plasma.
Biomedical chromatography : BMC 1995;9(5):226-8.
1995: D S Thompson; A Greco; A A Miller; Nuggehally R Srinivas; K B Igwenezue; J D Hainsworth; L P Schacter; S Kaul; RH Barbhaiya; C Garrow
A phase I study of etoposide phosphate administered as a daily 30-minute infusion for 5 days.
Clinical pharmacology and therapeutics 1995;57(5):499-507.
1995: FJ Belas; M A Phillips; Nuggehally R Srinivas; RH Barbhaiya; Ian A Blair
Simultaneous determination of nadolol enantiomers in human plasma by high-performance liquid chromatography using fluorescence detection.
Biomedical chromatography : BMC 1995;9(3):140-5.
1995: Nuggehally R Srinivas; Wen Chyi Shyu; D Upmalis; J S Lee; RH Barbhaiya
Lack of pharmacokinetic interaction between butorphanol tartrate nasal spray and sumatriptan succinate.
Journal of clinical pharmacology 1995;35(4):432-7.
1995: Nuggehally R Srinivas; Wen Chyi Shyu; Vinod R Shah; D A Campbell; RH Barbhaiya
High-performance liquid chromatographic assay for the quantitation of nadolol in human plasma using fluorescence detection.
Biomedical chromatography : BMC 1995;9(2):75-9.
1995: Nuggehally R Srinivas; Wen Chyi Shyu; RH Barbhaiya
Gas chromatographic determination of enantiomers as diastereomers following pre-column derivatization and applications to pharmacokinetic studies: a review.
Biomedical chromatography : BMC 1995;9(1):1-9.
1994: Nuggehally R Srinivas
A need for a uniform approach for indexing data of the stereoisomers.
Biomedical chromatography : BMC 1994;8(3):151.
1994: Nuggehally R Srinivas
A note on chromatographic analysis of enantiomers by indirect method.
Biomedical chromatography : BMC 1994;8(1):52.
1992: Nuggehally R Srinivas; L N Igwemezie
Chiral separation by high performance liquid chromatography. I. Review on indirect separation of enantiomers as diastereomeric derivatives using ultraviolet, fluorescence and electrochemical detection.
Biomedical chromatography : BMC 1992;6(4):163-7.