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Srinivasa Srinivasula

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Liao Wentao; Xiao Qi; Tchikov Vladimir; Fujita Ken-ichi; Yang Wensheng; Wincovitch Stephen; Garfield Susan; Conze Dietrich; El-Deiry Wafik S; Schütze Stefan; Srinivasula Srinivasa M
CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation.
Srinivasula Srinivasa M; Ashwell Jonathan D
IAPs: what's in a name?
Ma X; Kalakonda S; Srinivasula S M; Reddy S P; Platanias L C; Kalvakolanu D V
GRIM-19 associates with the serine protease HtrA2 for promoting cell death.

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2008: Liao Wentao; Xiao Qi; Tchikov Vladimir; Fujita Ken-ichi; Yang Wensheng; Wincovitch Stephen; Garfield Susan; Conze Dietrich; El-Deiry Wafik S; Schütze Stefan; Srinivasula Srinivasa M
CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation.
Current biology : CB 2008;18(9):641-9.
2008: Srinivasula Srinivasa M; Ashwell Jonathan D
IAPs: what's in a name?
Molecular cell 2008;30(2):123-35.
2007: Ma X; Kalakonda S; Srinivasula S M; Reddy S P; Platanias L C; Kalvakolanu D V
GRIM-19 associates with the serine protease HtrA2 for promoting cell death.
Oncogene 2007;26(33):4842-9.
2006: Wu Chuan-Jin; Conze Dietrich B; Li Tao; Srinivasula Srinivasa M; Ashwell Jonathan D
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]
Nature cell biology 2006;8(4):398-406.
2005: Chao Yang; Shiozaki Eric N; Srinivasula Srinivasa M; Rigotti Daniel J; Fairman Robert; Shi Yigong
Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation.
PLoS biology 2005;3(6):e183.
2004: Gupta Sanjeev; Singh Rajesh; Datta Pinaki; Zhang Zhijia; Orr Christopher; Lu Zhixian; Dubois Garrett; Zervos Antonis S; Meisler Miriam H; Srinivasula Srinivasa M; Fernandes-Alnemri Teresa; Alnemri Emad S
The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.
The Journal of biological chemistry 2004;279(44):45844-54.
2004: Saleh Maya; Vaillancourt John P; Graham Rona K; Huyck Matthew; Srinivasula Srinivasa M; Alnemri Emad S; Steinberg Martin H; Nolan Vikki; Baldwin Clinton T; Hotchkiss Richard S; Buchman Timothy G; Zehnbauer Barbara A; Hayden Michael R; Farrer Lindsay A; Roy Sophie; Nicholson Donald W
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Nature 2004;429(6987):75-9.
2004: Yanamandra Niranjan; Kondraganti Shakuntala; Srinivasula Srinivasa M; Gujrati Meena; Olivero William C; Dinh Dzung H; Rao Jasti S
Activation of caspase-9 with irradiation inhibits invasion and angiogenesis in SNB19 human glioma cells.
Oncogene 2004;23(13):2339-46.
2003: Jones Julie M; Datta Pinaki; Srinivasula Srinivasa M; Ji Weizhen; Gupta Sanjeev; Zhang ZhiJia; Davies Erika; Hajnóczky György; Saunders Thomas L; Van Keuren Margaret L; Fernandes-Alnemri Teresa; Meisler Miriam H; Alnemri Emad S
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice.
Nature 2003;425(6959):721-7.
2003: Hegde Ramesh; Srinivasula Srinivasa M; Datta Pinaki; Madesh Muniswamy; Wassell Richard; Zhang ZhiJia; Cheong NaEun; Nejmeh Julie; Fernandes-Alnemri Teresa; Hoshino Shin-ichi; Alnemri Emad S
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.
The Journal of biological chemistry 2003;278(40):38699-706.
2003: Zeuner A; Eramo A; Testa U; Felli N; Pelosi E; Mariani G; Srinivasula S M; Alnemri E S; Condorelli G; Peschle C; De Maria R
Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1.
Cell death and differentiation 2003;10(8):905-13.
2003: Srinivasula Srinivasa M; Gupta Sanjeev; Datta Pinaki; Zhang ZhiJia; Hegde Ramesh; Cheong NaEun; Fernandes-Alnemri Teresa; Alnemri Emad S
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
The Journal of biological chemistry 2003;278(34):31469-72.
2003: Chang David W; Ditsworth Dara; Liu Hongtu; Srinivasula Srinivasa M; Alnemri Emad S; Yang Xiaolu
Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases.
The Journal of biological chemistry 2003;278(19):16466-9.
2003: Kandasamy Karthikeyan; Srinivasula Srinivasa M; Alnemri Emad S; Thompson Craig B; Korsmeyer Stanley J; Bryant Joseph L; Srivastava Rakesh K
Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
Cancer research 2003;63(7):1712-21.
2003: Jia Li; Patwari Yasmeen; Kelsey Stephen M; Srinivasula Srinivasa M; Agrawal Samir G; Alnemri Emad S; Newland Adrian C
Role of Smac in human leukaemic cell apoptosis and proliferation.
Oncogene 2003;22(11):1589-99.
2003: Cilenti Lucia; Lee Younghee; Hess Sibylle; Srinivasula Srinivasa; Park Kwon Moo; Junqueira Daniela; Davis Hedvika; Bonventre Joseph V; Alnemri Emad S; Zervos Antonis S
Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.
The Journal of biological chemistry 2003;278(13):11489-94.
2003: Shiozaki Eric N; Chai Jijie; Rigotti Daniel J; Riedl Stefan J; Li Pingwei; Srinivasula Srinivasa M; Alnemri Emad S; Fairman Robert; Shi Yigong
Mechanism of XIAP-mediated inhibition of caspase-9.
Molecular cell 2003;11(2):519-27.
2002: Pistritto G; Jost M; Srinivasula S M; Baffa R; Poyet J-L; Kari C; Lazebnik Y; Rodeck U; Alnemri E S
Expression and transcriptional regulation of caspase-14 in simple and complex epithelia.
Cell death and differentiation 2002;9(9):995-1006.
2002: Li Wenyu; Srinivasula Srinivasa M; Chai Jijie; Li Pingwei; Wu Jia-Wei; Zhang ZhiJia; Alnemri Emad S; Shi Yigong
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
Nature structural biology 2002;9(6):436-41.
2002: Srinivasula Srinivasa M; Poyet Jean-Luc; Razmara Marjaneh; Datta Pinaki; Zhang ZhiJia; Alnemri Emad S
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1.
The Journal of biological chemistry 2002;277(24):21119-22.
2002: Zhan Y; Hegde R; Srinivasula S M; Fernandes-Alnemri T; Alnemri E S
Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.
Cell death and differentiation 2002;9(4):439-47.
2002: Guo Yin; Srinivasula Srinivasa M; Druilhe Anne; Fernandes-Alnemri Teresa; Alnemri Emad S
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.
The Journal of biological chemistry 2002;277(16):13430-7.
2002: Razmara Marjaneh; Srinivasula Srinivasa M; Wang Lin; Poyet Jean-Luc; Geddes Brad J; DiStefano Peter S; Bertin John; Alnemri Emad S
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
The Journal of biological chemistry 2002;277(16):13952-8.
2002: Madesh Muniswamy; Antonsson Bruno; Srinivasula Srinivasa M; Alnemri Emad S; Hajnóczky György
Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization.
The Journal of biological chemistry 2002;277(7):5651-9.
2002: Srinivasula Srinivasa M; Datta Pinaki; Kobayashi Masatomo; Wu Jia Wei; Fujioka Miki; Hegde Ramesh; Zhang ZhiJia; Mukattash Rula; Fernandes-Alnemri Teresa; Shi Yigong; Jaynes James B; Alnemri Emad S
sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein.
Current biology : CB 2002;12(2):125-30.
2002: Hegde Ramesh; Srinivasula Srinivasa M; Zhang ZhiJia; Wassell Richard; Mukattash Rula; Cilenti Lucia; DuBois Garrett; Lazebnik Yuri; Zervos Antonis S; Fernandes-Alnemri Teresa; Alnemri Emad S
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.
The Journal of biological chemistry 2002;277(1):432-8.
2001: Chai J; Wu Q; Shiozaki E; Srinivasula S M; Alnemri E S; Shi Y
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.
Cell 2001;107(3):399-407.
2001: Jia L; Patwari Y; Srinivasula S M; Newland A C; Fernandes-Alnemri T; Alnemri E S; Kelsey S M
Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis.
Oncogene 2001;20(35):4817-26.
2001: Jia L; Srinivasula S M; Liu F T; Newland A C; Fernandes-Alnemri T; Alnemri E S; Kelsey S M
Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells.
Blood 2001;98(2):414-21.
2001: Poyet J L; Srinivasula S M; Tnani M; Razmara M; Fernandes-Alnemri T; Alnemri E S
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.
The Journal of biological chemistry 2001;276(30):28309-13.
2001: Druilhe A; Srinivasula S M; Razmara M; Ahmad M; Alnemri E S
Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins.
Cell death and differentiation 2001;8(6):649-57.
2001: Condorelli F; Salomoni P; Cotteret S; Cesi V; Srinivasula S M; Alnemri E S; Calabretta B
Caspase cleavage enhances the apoptosis-inducing effects of BAD.
Molecular and cellular biology 2001;21(9):3025-36.
2001: Bertin J; Wang L; Guo Y; Jacobson M D; Poyet J L; Srinivasula S M; Merriam S; DiStefano P S; Alnemri E S
CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
The Journal of biological chemistry 2001;276(15):11877-82.
2001: Chai J; Shiozaki E; Srinivasula S M; Wu Q; Datta P; Alnemri E S; Shi Y;
Structural basis of caspase-7 inhibition by XIAP.
Cell 2001;104(5):769-80.
2001: Srinivasula S M; Hegde R; Saleh A; Datta P; Shiozaki E; Chai J; Lee R A; Robbins P D; Fernandes-Alnemri T; Shi Y; Alnemri E S
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.
Nature 2001;410(6824):112-6.
2001: Poyet J L; Srinivasula S M; Alnemri E S
vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma.
The Journal of biological chemistry 2001;276(5):3183-7.
2001: Srinivasula S M; Saleh A; Ahmad M; Fernandes-Alnemri T; Alnemri E S
Isolation and assay of caspases.
Methods in cell biology 2001;66():1-27.
2000: Bertin J; Guo Y; Wang L; Srinivasula S M; Jacobson M D; Poyet J L; Merriam S; Du M Q; Dyer M J; Robison K E; DiStefano P S; Alnemri E S
CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.
The Journal of biological chemistry 2000;275(52):41082-6.
2000: Poyet J L; Srinivasula S M; Lin J H; Fernandes-Alnemri T; Yamaoka S; Tsichlis P N; Alnemri E S
Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization.
The Journal of biological chemistry 2000;275(48):37966-77.
2000: Srinivasula S M; Datta P; Fan X J; Fernandes-Alnemri T; Huang Z; Alnemri E S
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
The Journal of biological chemistry 2000;275(46):36152-7.
2000: Saleh A; Srinivasula S M; Balkir L; Robbins P D; Alnemri E S
Negative regulation of the Apaf-1 apoptosome by Hsp70.
Nature cell biology 2000;2(8):476-83.
1999: De Maria R; Zeuner A; Eramo A; Domenichelli C; Bonci D; Grignani F; Srinivasula S M; Alnemri E S; Testa U; Peschle C
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1.
Nature 1999;401(6752):489-93.
1999: Qin H; Srinivasula S M; Wu G; Fernandes-Alnemri T; Alnemri E S; Shi Y
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Nature 1999;399(6736):549-57.
1999: Srinivasula S M; Ahmad M; Lin J H; Poyet J L; Fernandes-Alnemri T; Tsichlis P N; Alnemri E S
CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.
The Journal of biological chemistry 1999;274(25):17946-54.
1999: Saleh A; Srinivasula S M; Acharya S; Fishel R; Alnemri E S
Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.
The Journal of biological chemistry 1999;274(25):17941-5.
1999: Srinivasula S M; Ahmad M; Guo Y; Zhan Y; Lazebnik Y; Fernandes-Alnemri T; Alnemri E S
Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis.
Cancer research 1999;59(5):999-1002.
1999: Kang J J; Schaber M D; Srinivasula S M; Alnemri E S; Litwack G; Hall D J; Bjornsti M A
Cascades of mammalian caspase activation in the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 1999;274(5):3189-98.
1998: Ahmad M; Srinivasula S M; Hegde R; Mukattash R; Fernandes-Alnemri T; Alnemri E S
Identification and characterization of murine caspase-14, a new member of the caspase family.
Cancer research 1998;58(22):5201-5.
1998: Srinivasula S M; Ahmad M; Fernandes-Alnemri T; Alnemri E S
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
Molecular cell 1998;1(7):949-57.
1998: Srinivasula S M; Ahmad M; MacFarlane M; Luo Z; Huang Z; Fernandes-Alnemri T; Alnemri E S
Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits.
The Journal of biological chemistry 1998;273(17):10107-11.
1998: Hegde R; Srinivasula S M; Ahmad M; Fernandes-Alnemri T; Alnemri E S
Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.
The Journal of biological chemistry 1998;273(14):7783-6.
1997: MacFarlane M; Ahmad M; Srinivasula S M; Fernandes-Alnemri T; Cohen G M; Alnemri E S
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.
The Journal of biological chemistry 1997;272(41):25417-20.
1997: Srinivasula S M; Ahmad M; Ottilie S; Bullrich F; Banks S; Wang Y; Fernandes-Alnemri T; Croce C M; Litwack G; Tomaselli K J; Armstrong R C; Alnemri E S
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.
The Journal of biological chemistry 1997;272(30):18542-5.
1997: Ahmad M; Srinivasula S M; Wang L; Talanian R V; Litwack G; Fernandes-Alnemri T; Alnemri E S
CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.
Cancer research 1997;57(4):615-9.
1997: Ahmad M; Srinivasula S M; Wang L; Litwack G; Fernandes-Alnemri T; Alnemri E S
Spodoptera frugiperda caspase-1, a novel insect death protease that cleaves the nuclear immunophilin FKBP46, is the target of the baculovirus antiapoptotic protein p35.
The Journal of biological chemistry 1997;272(3):1421-4.
1996: Srinivasula S M; Ahmad M; Fernandes-Alnemri T; Litwack G; Alnemri E S
Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14486-91.
1996: Srinivasula S M; Fernandes-Alnemri T; Zangrilli J; Robertson N; Armstrong R C; Wang L; Trapani J A; Tomaselli K J; Litwack G; Alnemri E S
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.
The Journal of biological chemistry 1996;271(43):27099-106.
1996: Fernandes-Alnemri T; Armstrong R C; Krebs J; Srinivasula S M; Wang L; Bullrich F; Fritz L C; Trapani J A; Tomaselli K J; Litwack G; Alnemri E S
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7464-9.

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Srinivasa Srinivasula

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