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Srinivasa Srinivasula

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Srinivasa M Srinivasula; Jonathan D Ashwell
A20: more than one way to skin a cat.
Ken-Ichi Fujita; Srinivasa M Srinivasula
TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS).
Sudhanshu Shukla; Ken-ichi Fujita; Qi Xiao; Zhiyong Liao; Susan Garfield; Srinivasa M Srinivasula
A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface.

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All Publications

2011: Srinivasa M Srinivasula; Jonathan D Ashwell
A20: more than one way to skin a cat.
Molecular cell 2011;44(4):511-2.
2011: Ken-Ichi Fujita; Srinivasa M Srinivasula
TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS).
Autophagy 2011;7(5):552-4.
2011: Sudhanshu Shukla; Ken-ichi Fujita; Qi Xiao; Zhiyong Liao; Susan Garfield; Srinivasa M Srinivasula
A shear stress responsive gene product PP1201 protects against Fas-mediated apoptosis by reducing Fas expression on the cell surface.
Apoptosis : an international journal on programmed cell death 2011;16(2):162-73.
2011: Ken-ichi Fujita; Daisuke Maeda; Qi Xiao; Srinivasa M Srinivasula
Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1427-32.
2010: Afshin Samali; Simone Fulda; Adrienne M Gorman; Osamu Hori; Srinivasa M Srinivasula
Cell stress and cell death.
International journal of cell biology 2010;2010():245803.
2009: Ken-ichi Fujita; Srinivasa M Srinivasula
Ubiquitination and TNFR1 signaling.
Results and problems in cell differentiation 2009;49():87-114.
2008: Wentao Liao; Qi Xiao; Vladimir Tchikov; Ken-ichi Fujita; Wensheng Yang; Stephen Wincovitch; Susan Garfield; Dietrich Conze; Wafik S El-Deiry; Stefan Schütze; Srinivasa M Srinivasula
CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation.
Current biology : CB 2008;18(9):641-9.
2008: Srinivasa M Srinivasula; Jonathan D Ashwell
IAPs: what's in a name?
Molecular cell 2008;30(2):123-35.
2007: Xinrong Ma; Sudhakar Kalakonda; Srinivasa M Srinivasula; SEKHAR POTHIREDDY; Leonidas C Platanias; Dhan V Kalvakolanu
GRIM-19 associates with the serine protease HtrA2 for promoting cell death.
Oncogene 2007;26(33):4842-9.
2006: Chuan-Jin Wu; Dietrich B Conze; Tao Li; Srinivasa M Srinivasula; Jonathan D Ashwell
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].
Nature cell biology 2006;8(4):398-406.
2005: Yang Chao; Eric N Shiozaki; Srinivasa M Srinivasula; Daniel J Rigotti; Robert Fairman; Yigong Shi
Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation.
PLoS biology 2005;3(6):e183.
2004: Sanjeev Gupta; Rajesh Singh; Pinaki Datta; Zhijia Zhang; Christopher Orr; Zhixian Lu; Garrett C DuBois; Antonis S Zervos; Miriam H Meisler; Srinivasa M Srinivasula; Teresa Fernandes-Alnemri; Emad S Alnemri
The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.
The Journal of biological chemistry 2004;279(44):45844-54.
2004: Maya Saleh; John P Vaillancourt; Graham Kyrenia Rona; Matthew Huyck; Srinivasa M Srinivasula; Emad S Alnemri; Martin H Steinberg; Vikki G Nolan; Clinton T Baldwin; Richard S Hotchkiss; Timothy G Buchman; Barbara A Zehnbauer; Michael R Hayden; Lindsay A Farrer; Sophie Roy; Donald W Nicholson
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Nature 2004;429(6987):75-9.
2004: Niranjan Yanamandra; Shakuntala Kondraganti; Srinivasa M Srinivasula; Meena Gujrati; Charles William Olivero; Dzung Hong Dinh; Jasti Sambasiva Rao
Activation of caspase-9 with irradiation inhibits invasion and angiogenesis in SNB19 human glioma cells.
Oncogene 2004;23(13):2339-46.
2003: Julie M Jones; Pinaki Datta; Srinivasa M Srinivasula; Weizhen Ji; Sanjeev Gupta; ZhiJia Zhang; Erika Davies; Gyorgy Hajn\u2264czky; Thomas L Saunders; Margaret L Van Keuren; Teresa Fernandes-Alnemri; Miriam H Meisler; Emad S Alnemri
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice.
Nature 2003;425(6959):721-7.
2003: Ramesh Hegde; Srinivasa M Srinivasula; Pinaki Datta; Muniswamy Madesh; Richard Wassell; ZhiJia Zhang; NaEun Cheong; julie nijmeh; Teresa Fernandes-Alnemri; Shin-ichi Hoshino; Emad S Alnemri
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.
The Journal of biological chemistry 2003;278(40):38699-706.
2003: Srinivasa M Srinivasula; Sanjeev Gupta; Pinaki Datta; ZhiJia Zhang; Ramesh Hegde; NaEun Cheong; Teresa Fernandes-Alnemri; Emad S Alnemri
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
The Journal of biological chemistry 2003;278(34):31469-72.
2003: Ann Zeuner; Adriana Eramo; Ugo Testa; Nadia Felli; Elvira Pelosi; Gualtiero Mariani; Srinivasa M Srinivasula; Emad S Alnemri; Gianluigi Condorelli; Cesare Peschle; Ruggero De Maria
Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1.
Cell death and differentiation 2003;10(8):905-13.
2003: David W Chang; Dara Ditsworth; Hongtu Liu; Srinivasa M Srinivasula; Emad S Alnemri; Xiaolu Yang
Oligomerization is a general mechanism for the activation of apoptosis initiator and inflammatory procaspases.
The Journal of biological chemistry 2003;278(19):16466-9.
2003: Karthikeyan Kandasamy; Srinivasa M Srinivasula; Emad S Alnemri; Craig Thompson; Stanley J Korsmeyer; Joseph L Bryant; Rakesh K Srivastava
Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
Cancer research 2003;63(7):1712-21.
2003: Lucia Cilenti; Younghee Lee; Sibylle Hess; Srinivasa M Srinivasula; Kwon Moo Park; Daniela Junqueira; Hedvika Davis; Joseph V Bonventre; Emad S Alnemri; Antonis S Zervos
Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.
The Journal of biological chemistry 2003;278(13):11489-94.
2003: Li Jia; Yasmeen Patwari; Stephen M Kelsey; Srinivasa M Srinivasula; Samir G Agrawal; Emad S Alnemri; Adrian C Newland
Role of Smac in human leukaemic cell apoptosis and proliferation.
Oncogene 2003;22(11):1589-99.
2003: Eric N Shiozaki; Jijie Chai; Daniel J Rigotti; Stefan J Riedl; Pingwei Li; Srinivasa M Srinivasula; Emad S Alnemri; Robert Fairman; Yigong Shi
Mechanism of XIAP-mediated inhibition of caspase-9.
Molecular cell 2003;11(2):519-27.
2002: G Pistritto; Monika Jost; Srinivasa M Srinivasula; Raffaele Baffa; Jean-Luc Poyet; Csaba Kari; Yuri Lazebnik; Ulrich Rodeck; Emad S Alnemri
Expression and transcriptional regulation of caspase-14 in simple and complex epithelia.
Cell death and differentiation 2002;9(9):995-1006.
2002: Srinivasa M Srinivasula; Jean-Luc Poyet; Marjaneh Razmara; Pinaki Datta; ZhiJia Zhang; Emad S Alnemri
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1.
The Journal of biological chemistry 2002;277(24):21119-22.
2002: Wenyu Li; Srinivasa M Srinivasula; Jijie Chai; Pingwei Li; Jia-Wei Wu; ZhiJia Zhang; Emad S Alnemri; Yigong Shi
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
Nature structural biology 2002;9(6):436-41.
2002: Yin Guo; Srinivasa M Srinivasula; Anne Druilhe; Teresa Fernandes-Alnemri; Emad S Alnemri
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.
The Journal of biological chemistry 2002;277(16):13430-7.
2002: Marjaneh Razmara; Srinivasa M Srinivasula; Lin Wang; Jean-Luc Poyet; Brad J Geddes; Peter S DiStefano; John Bertin; Emad S Alnemri
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
The Journal of biological chemistry 2002;277(16):13952-8.
2002: Y Zhan; Ramesh Hegde; Srinivasa M Srinivasula; Teresa Fernandes-Alnemri; Emad S Alnemri
Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.
Cell death and differentiation 2002;9(4):439-47.
2002: Muniswamy Madesh; Bruno Antonsson; Srinivasa M Srinivasula; Emad S Alnemri; Gyorgy Hajn\u2264czky
Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization.
The Journal of biological chemistry 2002;277(7):5651-9.
2002: Srinivasa M Srinivasula; Pinaki Datta; Masatomo Kobayashi; Jia Wei Wu; Miki Fujioka; Ramesh Hegde; ZhiJia Zhang; Rula Mukattash; Teresa Fernandes-Alnemri; Yigong Shi; James B Jaynes; Emad S Alnemri
sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein.
Current biology : CB 2002;12(2):125-30.
2002: Ramesh Hegde; Srinivasa M Srinivasula; ZhiJia Zhang; Richard Wassell; Rula Mukattash; Lucia Cilenti; Garrett C DuBois; Yuri Lazebnik; Antonis S Zervos; Teresa Fernandes-Alnemri; Emad S Alnemri
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.
The Journal of biological chemistry 2002;277(1):432-8.
2001: Jijie Chai; Q Wu; Eric N Shiozaki; Srinivasa M Srinivasula; Emad S Alnemri; Yigong Shi
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding.
Cell 2001;107(3):399-407.
2001: Li Jia; Yasmeen Patwari; Srinivasa M Srinivasula; Adrian C Newland; Teresa Fernandes-Alnemri; Emad S Alnemri; Stephen M Kelsey
Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis.
Oncogene 2001;20(35):4817-26.
2001: Jean-Luc Poyet; Srinivasa M Srinivasula; Mehdi Tnani; Marjaneh Razmara; Teresa Fernandes-Alnemri; Emad S Alnemri
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.
The Journal of biological chemistry 2001;276(30):28309-13.
2001: Li Jia; Srinivasa M Srinivasula; F T Liu; Adrian C Newland; Teresa Fernandes-Alnemri; E S Alnemri; Stephen M Kelsey
Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells.
Blood 2001;98(2):414-21.
2001: A Druilhe; Srinivasa M Srinivasula; Marjaneh Razmara; M Ahmad; Emad S Alnemri
Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins.
Cell death and differentiation 2001;8(6):649-57.
2001: Fabrizio Condorelli; P Salomoni; S Cotteret; Vincenzo Cesi; Srinivasa M Srinivasula; Emad S Alnemri; Bruno Calabretta
Caspase cleavage enhances the apoptosis-inducing effects of BAD.
Molecular and cellular biology 2001;21(9):3025-36.
2001: John Bertin; Lin Wang; Y Guo; Michael D Jacobson; Jean-Luc Poyet; Srinivasa M Srinivasula; Sarah Merriam; Peter S DiStefano; Emad S Alnemri
CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
The Journal of biological chemistry 2001;276(15):11877-82.
2001: Jijie Chai; Eric N Shiozaki; Srinivasa M Srinivasula; Q Wu; Pinaki Datta; Emad S Alnemri; Yigong Shi; P Dataa
Structural basis of caspase-7 inhibition by XIAP.
Cell 2001;104(5):769-80.
2001: Srinivasa M Srinivasula; Ramesh Hegde; A Saleh; Pinaki Datta; Eric N Shiozaki; Jijie Chai; R A Lee; P D Robbins; Teresa Fernandes-Alnemri; Yigong Shi; Emad S Alnemri
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.
Nature 2001;410(6824):112-6.
2001: Jean-Luc Poyet; Srinivasa M Srinivasula; Emad S Alnemri
vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma.
The Journal of biological chemistry 2001;276(5):3183-7.
2001: Srinivasa M Srinivasula; A Saleh; M Ahmad; Teresa Fernandes-Alnemri; Emad S Alnemri
Isolation and assay of caspases.
Methods in cell biology 2001;66():1-27.
2000: John Bertin; Y Guo; Lin Wang; Srinivasa M Srinivasula; Michael D Jacobson; Jean-Luc Poyet; Sarah Merriam; M Q Du; M J Dyer; K E Robison; Peter S DiStefano; Emad S Alnemri
CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.
The Journal of biological chemistry 2000;275(52):41082-6.
2000: Jean-Luc Poyet; Srinivasa M Srinivasula; Jun-Hsiang Lin; Teresa Fernandes-Alnemri; S Yamaoka; Philip Tsichlis; Emad S Alnemri
Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization.
The Journal of biological chemistry 2000;275(48):37966-77.
2000: Srinivasa M Srinivasula; Pinaki Datta; X J Fan; Teresa Fernandes-Alnemri; Ziwei Huang; Emad S Alnemri
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
The Journal of biological chemistry 2000;275(46):36152-7.
2000: A Saleh; Srinivasa M Srinivasula; L Balkir; P D Robbins; Emad S Alnemri
Negative regulation of the Apaf-1 apoptosome by Hsp70.
Nature cell biology 2000;2(8):476-83.
1999: Ruggero De Maria; Ann Zeuner; Adriana Eramo; C Domenichelli; Désirée Bonci; Francesco Grignani; Srinivasa M Srinivasula; Emad S Alnemri; Ugo Testa; Cesare Peschle
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1.
Nature 1999;401(6752):489-93.
1999: Srinivasa M Srinivasula; M Ahmad; Jun-Hsiang Lin; Jean-Luc Poyet; Teresa Fernandes-Alnemri; Philip Tsichlis; Emad S Alnemri
CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.
The Journal of biological chemistry 1999;274(25):17946-54.
1999: A Saleh; Srinivasa M Srinivasula; Samir Acharya; Richard Fishel; Emad S Alnemri
Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.
The Journal of biological chemistry 1999;274(25):17941-5.
1999: H Qin; Srinivasa M Srinivasula; G Wu; Teresa Fernandes-Alnemri; Emad S Alnemri; Yigong Shi
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1.
Nature 1999;399(6736):549-57.
1999: Srinivasa M Srinivasula; M Ahmad; Yin Guo; Y Zhan; Yuri Lazebnik; Teresa Fernandes-Alnemri; Emad S Alnemri
Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis.
Cancer research 1999;59(5):999-1002.
1999: J J Kang; M D Schaber; Srinivasa M Srinivasula; Emad S Alnemri; Gerald Litwack; David J Hall; Mary-Ann Bjornsti
Cascades of mammalian caspase activation in the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 1999;274(5):3189-98.
1998: M Ahmad; Srinivasa M Srinivasula; Ramesh Hegde; Rula Mukattash; Teresa Fernandes-Alnemri; Emad S Alnemri
Identification and characterization of murine caspase-14, a new member of the caspase family.
Cancer research 1998;58(22):5201-5.
1998: Srinivasa M Srinivasula; M Ahmad; Teresa Fernandes-Alnemri; Emad S Alnemri
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
Molecular cell 1998;1(7):949-57.
1998: Srinivasa M Srinivasula; M Ahmad; M MacFarlane; Zhaowen Luo; Ziwei Huang; Teresa Fernandes-Alnemri; Emad S Alnemri
Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits.
The Journal of biological chemistry 1998;273(17):10107-11.
1998: Ramesh Hegde; Srinivasa M Srinivasula; M Ahmad; Teresa Fernandes-Alnemri; Emad S Alnemri
Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist.
The Journal of biological chemistry 1998;273(14):7783-6.
1997: M MacFarlane; M Ahmad; Srinivasa M Srinivasula; Teresa Fernandes-Alnemri; G M Cohen; Emad S Alnemri
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.
The Journal of biological chemistry 1997;272(41):25417-20.
1997: Srinivasa M Srinivasula; M Ahmad; S Ottilie; Florencia Bullrich; S Banks; Youli Wang; Teresa Fernandes-Alnemri; Carlo M Croce; Gerald Litwack; Kevin J Tomaselli; Robert C Armstrong; Emad S Alnemri
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis.
The Journal of biological chemistry 1997;272(30):18542-5.
1997: M Ahmad; Srinivasa M Srinivasula; L Wang; Robert Talanian; Gerald Litwack; Teresa Fernandes-Alnemri; E S Alnemri
CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.
Cancer research 1997;57(4):615-9.
1997: M Ahmad; Srinivasa M Srinivasula; L Wang; Gerald Litwack; Teresa Fernandes-Alnemri; E S Alnemri
Spodoptera frugiperda caspase-1, a novel insect death protease that cleaves the nuclear immunophilin FKBP46, is the target of the baculovirus antiapoptotic protein p35.
The Journal of biological chemistry 1997;272(3):1421-4.
1996: Srinivasa M Srinivasula; M Ahmad; Teresa Fernandes-Alnemri; Gerald Litwack; Emad S Alnemri
Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14486-91.
1996: Srinivasa M Srinivasula; Teresa Fernandes-Alnemri; James G Zangrilli; N Robertson; Robert C Armstrong; L Wang; J A Trapani; Kevin J Tomaselli; Gerald Litwack; Emad S Alnemri
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.
The Journal of biological chemistry 1996;271(43):27099-106.
1996: Teresa Fernandes-Alnemri; Robert C Armstrong; J Krebs; Srinivasa M Srinivasula; L Wang; Florencia Bullrich; Lawrence C Fritz; J A Trapani; Kevin J Tomaselli; Gerald Litwack; Emad S Alnemri
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7464-9.