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Rakesh Srivastava

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Ivana Gojo; Rena Lapidus; Mariola Sadowska; Rakesh K Srivastava; Ming Tan; Bean N Anyang; Maria R Baer; Jan H Beumer; France Carrier; Igor Espinoza-Delgado; Hongbin Fang; Douglas D Ross
Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia.
Sharmila Shankar; Suthakar Ganapathy; Rakesh K Srivastava
Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.
Sharmila Shankar; Qinghe Chen; Suthakar Ganapathy; Karan P Singh; Rakesh K Srivastava
Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms.

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2013: Ivana Gojo; Rena Lapidus; Mariola Sadowska; Rakesh K Srivastava; Ming Tan; Bean N Anyang; Maria R Baer; Jan H Beumer; France Carrier; Igor Espinoza-Delgado; Hongbin Fang; Douglas D Ross
Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(7):1838-51.
2008: Sharmila Shankar; Suthakar Ganapathy; Rakesh K Srivastava
Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(21):6855-66.
2008: Sharmila Shankar; Qinghe Chen; Suthakar Ganapathy; Karan P Singh; Rakesh K Srivastava
Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms.
Molecular cancer therapeutics 2008;7(8):2328-38.
2008: Tamer E Fandy; Sharmila Shankar; Rakesh K Srivastava
Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells.
Molecular cancer 2008;7():60.
2008: Sharmila Shankar; Rakesh K Srivastava
Histone deacetylase inhibitors: mechanisms and clinical significance in cancer: HDAC inhibitor-induced apoptosis.
Advances in experimental medicine and biology 2008;615():261-98.
2008: Sharmila Shankar; Qinghe Chen; Rakesh K Srivastava
Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor.
Journal of molecular signaling 2008;3():7.
2008: Sharmila Shankar; Suthakar Ganapathy; Qinghe Chen; Rakesh K Srivastava
Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis.
Molecular cancer 2008;7():16.
2008: Sharmila Shankar; Suthakar Ganapathy; Sunil R Hingorani; Rakesh K Srivastava
EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer.
Frontiers in bioscience : a journal and virtual library 2008;13():440-52.
2007: Rakesh K Srivastava; Qinghe Chen; Imtiaz Siddiqui; Krishna Sarva; Sharmila Shankar
Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21(/WAF1/CIP1).
Cell cycle (Georgetown, Tex.) 2007;6(23):2953-61.
2007: Sharmila Shankar; Imtiaz Siddiqui; Rakesh K Srivastava
Molecular mechanisms of resveratrol (3,4,5-trihydroxy-trans-stilbene) and its interaction with TNF-related apoptosis inducing ligand (TRAIL) in androgen-insensitive prostate cancer cells.
Molecular and cellular biochemistry 2007;304(1-2):273-85.
2007: Tamer E Fandy; Douglas Ross; Steven D Gore; Rakesh K Srivastava
Flavopiridol synergizes TRAIL cytotoxicity by downregulation of FLIPL.
Cancer chemotherapy and pharmacology 2007;60(3):313-9.
2007: Sharmila Shankar; Rakesh K Srivastava
Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa.
Carcinogenesis 2007;28(6):1277-86.
2007: Sharmila Shankar; Rakesh K Srivastava
Involvement of Bcl-2 family members, phosphatidylinositol 3'-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer.
International journal of oncology 2007;30(4):905-18.
2007: Sharmila Shankar; Qinghe Chen; Krishna Sarva; Imtiaz Siddiqui; Rakesh K Srivastava
Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis.
Journal of molecular signaling 2007;2():10.
2007: Sharmila Shankar; Qinghe Chen; Imtiaz Siddiqui; Krishna Sarva; Rakesh K Srivastava
Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential.
Journal of molecular signaling 2007;2():7.
2007: Sharmila Shankar; Ganapathy Suthakar; Rakesh K Srivastava
Epigallocatechin-3-gallate inhibits cell cycle and induces apoptosis in pancreatic cancer.
Frontiers in bioscience : a journal and virtual library 2007;12():5039-51.
2007: Sharmila Shankar; Suthakar Ganapathy; Rakesh K Srivastava
Green tea polyphenols: biology and therapeutic implications in cancer.
Frontiers in bioscience : a journal and virtual library 2007;12():4881-99.
2007: Sharmila Shankar; Gyanendra Singh; Rakesh K Srivastava
Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential.
Frontiers in bioscience : a journal and virtual library 2007;12():4839-54.
2006: Tamer E Fandy; Rakesh K Srivastava
Trichostatin A sensitizes TRAIL-resistant myeloma cells by downregulation of the antiapoptotic Bcl-2 proteins.
Cancer chemotherapy and pharmacology 2006;58(4):471-7.
2006: Naoko Takebe; Xiangfei Cheng; Tamer E Fandy; Rakesh K Srivastava; Suhlan Wu; Sharmila Shankar; Kenneth S. Bauer; John Shaughnessy; Guido Tricot
IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells.
Molecular cancer therapeutics 2006;5(2):457-66.
2005: Sharmila Shankar; Thiyam Ramsing Singh; Tamer E Fandy; Thitidaj Luetrakul; Douglas Ross; Rakesh K Srivastava
Interactive effects of histone deacetylase inhibitors and TRAIL on apoptosis in human leukemia cells: involvement of both death receptor and mitochondrial pathways.
International journal of molecular medicine 2005;16(6):1125-38.
2005: Thiyam Ramsing Singh; Sharmila Shankar; Rakesh K Srivastava
HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma.
Oncogene 2005;24(29):4609-23.
2005: Tamer E Fandy; Sharmila Shankar; Douglas Ross; Edward A Sausville; Rakesh K Srivastava
Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma.
Neoplasia (New York, N.Y.) 2005;7(7):646-57.
2005: Rupesh Chaturvedi; Rakesh K Srivastava; Akinori Hisatsune; Sharmila Shankar; Erik Lillehoj; K. Chul Kim
Augmentation of Fas ligand-induced apoptosis by MUC1 mucin.
International journal of oncology 2005;26(5):1169-76.
2005: Sharmila Shankar; Xufen Chen; Rakesh K Srivastava
Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo.
The Prostate 2005;62(2):165-86.
2004: Sharmila Shankar; Thiyam Ramsing Singh; Rakesh K Srivastava
Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: Intracellular mechanisms.
The Prostate 2004;61(1):35-49.
2004: Sharmila Shankar; Thiyam Ramsing Singh; Xufeng Chen; Hitesh Thakkar; Jason Firnin; Rakesh K Srivastava
The sequential treatment with ionizing radiation followed by TRAIL/Apo-2L reduces tumor growth and induces apoptosis of breast tumor xenografts in nude mice.
International journal of oncology 2004;24(5):1133-40.
2004: Sharmila Shankar; Rakesh K Srivastava
Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: mechanisms and clinical implications.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2004;7(2):139-56.
2003: Hongyan Wang; Qianben Wang; Rakesh K Srivastava; Shu Sheng Gong; Lixing Lao; Joseph D Fondell; Jia Bei Wang
Effects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferation.
Alternative therapies in health and medicine 2003;9(5):62-6.
2003: Thiyam Ramsing Singh; Sharmila Shankar; Xufen Chen; Mohammad Asim; Rakesh K Srivastava
Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo.
Cancer research 2003;63(17):5390-400.
2003: Aparna Ranjan; Leena Tarigopula; Rakesh K Srivastava; Olugbenga O Obasanjo; Eugene Obah
Effectiveness of the clinical pathway in the management of congestive heart failure.
Southern medical journal 2003;96(7):661-3.
2003: Karthikeyan Kandasamy; Srinivasa M Srinivasula; Emad S Alnemri; Craig Thompson; Stanley J Korsmeyer; Joseph L Bryant; Rakesh K Srivastava
Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release.
Cancer research 2003;63(7):1712-21.
2003: Xufeng Chen; Karthikeyan Kandasamy; Rakesh K Srivastava
Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappa B in tumor necrosis factor-related apoptosis-inducing ligand signaling.
Cancer research 2003;63(5):1059-66.
2002: Karthikeyan Kandasamy; Rakesh K Srivastava
Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells.
Cancer research 2002;62(17):4929-37.
2002: Yoon S Cho-Chung; Maria V Nesterova; Kevin G Becker; Rakesh K Srivastava; Yun Gyu Park; Youl-Nam Lee; Yee Sook Cho; Meyoung-Kin Kim; Catherine Neary; Chris Cheadle
Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy.
Annals of the New York Academy of Sciences 2002;968():22-36.
2002: Yee Sook Cho; Meyoung-Kon Kim; Langzhu Tan; Rakesh K Srivastava; Sudhir Agrawal; Yoon S Cho-Chung
Protein kinase A RIalpha antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(2):607-14.
2001: Rakesh K Srivastava
TRAIL/Apo-2L: mechanisms and clinical applications in cancer.
Neoplasia (New York, N.Y.) 2001;3(6):535-46.
2001: Hitesh Thakkar; Xufeng Chen; F Tyan; S Gim; H Robinson; C Lee; S K Pandey; C Nwokorie; N Onwudiwe; Rakesh K Srivastava
Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance.
The Journal of biological chemistry 2001;276(42):38361-9.
2001: Xufeng Chen; Hitesh Thakkar; F Tyan; S Gim; H Robinson; C Lee; S K Pandey; C Nwokorie; N Onwudiwe; Rakesh K Srivastava
Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer.
Oncogene 2001;20(42):6073-83.
2001: Rajatsubhra Biswas; Hyukjin Cha; J Marie Hardwick; Rakesh K Srivastava
Inhibition of drug-induced Fas ligand transcription and apoptosis by Bcl-XL.
Molecular and cellular biochemistry 2001;225(1-):7-20.
2001: A Suliman; A Lam; R Datta; Rakesh K Srivastava
Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways.
Oncogene 2001;20(17):2122-33.
2001: E J Kim; A Suliman; A Lam; Rakesh K Srivastava
Failure of Bcl-2 to block mitochondrial dysfunction during TRAIL-induced apoptosis. Tumor necrosis-related apoptosis-inducing ligand.
International journal of oncology 2001;18(1):187-94.
2000: Rakesh K Srivastava
Intracellular mechanisms of TRAIL and its role in cancer therapy.
Molecular cell biology research communications : MCBRC 2000;4(2):67-75.
2000: Rakesh K Srivastava; A R Srivastave; Yoon S Cho-Chung
Synergistic effects of 8-Cl-cAMP and retinoic acids in the inhibition of growth and induction of apoptosis in ovarian cancer cells: induction of retinoic acid receptor beta.
Molecular and cellular biochemistry 2000;204(1-2):1-9.
1999: Yoon S Cho-Chung; Maria V Nesterova; S Pepe; GR Lee; K Noguchi; Rakesh K Srivastava; AR Srivastava; Ozgül M Alper; Yun Gyu Park; Youl-Nam Lee
Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment.
Frontiers in bioscience : a journal and virtual library 1999;4():D898-907.
1999: S Deb; Christian Tessier; Anne Prigent-Tessier; Uriel Barkai; Susan Ferguson-Gottschall; Rakesh K Srivastava; J Faliszek; Geula Gibori
The expression of interleukin-6 (IL-6), IL-6 receptor, and gp130-kilodalton glycoprotein in the rat decidua and a decidual cell line: regulation by 17beta-estradiol and prolactin.
Endocrinology 1999;140(10):4442-50.
1999: Rakesh K Srivastava; STEVEN SOLLOTT; L Khan; Richard G Hansford; Edward G Lakatta; Dan Longo
Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis.
Molecular and cellular biology 1999;19(8):5659-74.
1999: Rakesh K Srivastava; Carl Y Sasaki; J Marie Hardwick; Dan Longo
Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription.
The Journal of experimental medicine 1999;190(2):253-65.
1999: Rakesh K Srivastava; AR Srivastava; Yoon S Cho-Chung; Dan Longo
Synergistic effects of retinoic acid and 8-chloro-adenosine 3',5'-cyclic monophosphate on the regulation of retinoic acid receptor beta and apoptosis: involvement of mitochondria.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1892-904.
1999: Rakesh K Srivastava; AR Srivastava; Prem Seth; S Agrawal; Yoon S Cho-Chung
Growth arrest and induction of apoptosis in breast cancer cells by antisense depletion of protein kinase A-RI alpha subunit: p53-independent mechanism of action.
Molecular and cellular biochemistry 1999;195(1-2):25-36.
1999: Rakesh K Srivastava; Quing Sheng Mi; J Marie Hardwick; Dan Longo
Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3775-80.
1999: Rakesh K Srivastava; AR Srivastava; Yoon S Cho-Chung; Dan Longo
Synergistic effects of retinoic acid and 8-Cl-cAMP on apoptosis require caspase-3 activation in human ovarian cancer cells.
Oncogene 1999;18(9):1755-63.
1998: Rakesh K Srivastava; Yan Gu; S Ayloo; Moshe Zilberstein; Geula Gibori
Developmental expression and regulation of basic fibroblast growth factor and vascular endothelial growth factor in rat decidua and in a decidual cell line.
Journal of molecular endocrinology 1998;21(3):355-62.
1998: Rakesh K Srivastava; Y N Lee; K Noguchi; Yun Gyu Park; M J Ellis; J S Jeong; S N Kim; Yoon S Cho-Chung
The RIIbeta regulatory subunit of protein kinase A binds to cAMP response element: an alternative cAMP signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6687-92.
1998: Rakesh K Srivastava; AR Srivastava; S J Korsmeyer; Maria V Nesterova; Yoon S Cho-Chung; Dan Longo
Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase.
Molecular and cellular biology 1998;18(6):3509-17.
1998: Rakesh K Srivastava; AR Srivastava; Yun Gyu Park; S Agrawal; Yoon S Cho-Chung
Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.
Breast cancer research and treatment 1998;49(2):97-107.
1998: Carlos M Telleria; L Zhong; S Deb; Rakesh K Srivastava; K S Park; N Sugino; Ok-Kyong Park-Sarge; Geula Gibori
Differential expression of the estrogen receptors alpha and beta in the rat corpus luteum of pregnancy: regulation by prolactin and placental lactogens.
Endocrinology 1998;139(5):2432-42.
1998: N Sugino; Moshe Zilberstein; Rakesh K Srivastava; Carlos M Telleria; S E Nelson; M Risk; J Y Chou; Geula Gibori
Establishment and characterization of a simian virus 40-transformed temperature-sensitive rat luteal cell line.
Endocrinology 1998;139(4):1936-42.
1998: Rakesh K Srivastava; AR Srivastava; Yoon S Cho-Chung
Synergistic effects of 8-chlorocyclic-AMP and retinoic acid on induction of apoptosis in Ewing's sarcoma CHP-100 cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(3):755-61.
1997: Yoon S Cho-Chung; Maria V Nesterova; AA Kondrashin; K Noguchi; Rakesh K Srivastava; S Pepe
Antisense-protein kinase A: a single-gene-based therapeutic approach.
Antisense & nucleic acid drug development 1997;7(3):217-23.
1996: Y Gu; Rakesh K Srivastava; D L Clarke; Daniel I H Linzer; Geula Gibori
The decidual prolactin receptor and its regulation by decidua-derived factors.
Endocrinology 1996;137(11):4878-85.
1995: Y Gu; Rakesh K Srivastava; J Ou; N L Krett; K E Mayo; Geula Gibori
Cell-specific expression of activin and its two binding proteins in the rat decidua: role of alpha 2-macroglobulin and follistatin.
Endocrinology 1995;136(9):3815-22.
1995: Rakesh K Srivastava; Y Gu; Moshe Zilberstein; J S Ou; K E Mayo; Janice Yang Chou; Geula Gibori
Development and characterization of a simian virus 40-transformed, temperature-sensitive rat antimesometrial decidual cell line.
Endocrinology 1995;136(5):1913-9.
1994: Y Gu; M J Soares; Rakesh K Srivastava; Geula Gibori
Expression of decidual prolactin-related protein in the rat decidua.
Endocrinology 1994;135(4):1422-7.
1994: Rakesh K Srivastava; Glen Van Der Kraak
Insulin as an amplifier of gonadotropin action on steroid production: mechanisms and sites of action in goldfish prematurational full-grown ovarian follicles.
General and comparative endocrinology 1994;95(1):60-70.
1994: Rakesh K Srivastava; Glen Van Der Kraak
Effects of activators of different intracellular signaling pathways on steroid production by goldfish vitellogenic ovarian follicles.
General and comparative endocrinology 1994;93(2):181-91.
1992: Rakesh K Srivastava
Changes in polyamines during embryonic development of Atlantic salmon, Salmo salar.
Comparative biochemistry and physiology. B, Comparative biochemistry 1992;102(1):97-101.