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Peter St George-Hyslop

Research Profile

Disorders

Alzheimer's Disease

Chemicals & Drugs

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Physiology

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Anatomy

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DNA Mutational Analysis

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Lili-Naz Hazrati; Patricia L Brooks; Nathalie Brouwers; Marc Cruts; Mahdi Ghani; Christine Sato; Kristel Sleegers; Peter St George-Hyslop; Christine Van Broeckhoven; Caroline Van Cauwenberghe; Ekaterina Rogaeva
Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.
Livia Bernardi; Annelisa Borelli; Maria Anfossi; Alessandra Clodomiro; Rosanna Colao; Francesco Comito; Maria Elena Conidi; Chiara Cupidi; S A M Curcio; Raffale Di Lorenzo; Francesca Frangipane; Maura Gallo; Silvana Geracitano; Mahdi Ghani; Rosa Anna Leone; Raffaele Maletta; Sandra Marzano; Maria Mirabelli; Danielle Moreno; Gianfranco Puccio; Ekaterina Rogaeva; Christine Sato; Nicoletta Smirne; Peter St George-Hyslop; Vincenzo Valenti; Zhengrui Xi; Maria Angela Zirilli; Amalia C Bruni
Epidemiology and genetics of frontotemporal dementia: a door-to-door survey in southern Italy.
Gyungah Jun; Carolina Koutras; Georges Levesque; Ann C McKee; Juliet A Moncaster; Sudha Seshadri; Peter St George-Hyslop; Philip A Wolf; Jacqueline Buros; Lee E Goldstein; Lindsay A Farrer
δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.

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2012: Lili-Naz Hazrati; Patricia L Brooks; Nathalie Brouwers; Marc Cruts; Mahdi Ghani; Christine Sato; Kristel Sleegers; Peter St George-Hyslop; Christine Van Broeckhoven; Caroline Van Cauwenberghe; Ekaterina Rogaeva
Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.
Neurobiology of aging 2012;33(12):2949.e5-2949.e12.
2012: Livia Bernardi; Annelisa Borelli; Maria Anfossi; Alessandra Clodomiro; Rosanna Colao; Francesco Comito; Maria Elena Conidi; Chiara Cupidi; S A M Curcio; Raffale Di Lorenzo; Francesca Frangipane; Maura Gallo; Silvana Geracitano; Mahdi Ghani; Rosa Anna Leone; Raffaele Maletta; Sandra Marzano; Maria Mirabelli; Danielle Moreno; Gianfranco Puccio; Ekaterina Rogaeva; Christine Sato; Nicoletta Smirne; Peter St George-Hyslop; Vincenzo Valenti; Zhengrui Xi; Maria Angela Zirilli; Amalia C Bruni
Epidemiology and genetics of frontotemporal dementia: a door-to-door survey in southern Italy.
Neurobiology of aging 2012;33(12):2948.e1-2948.e10.
2012: Gyungah Jun; Carolina Koutras; Georges Levesque; Ann C McKee; Juliet A Moncaster; Sudha Seshadri; Peter St George-Hyslop; Philip A Wolf; Jacqueline Buros; Lee E Goldstein; Lindsay A Farrer
δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.
PloS one 2012;7(9):e43728.
2012: Christiane Reitz; Ekaterina Rogaeva; Nicole Schupf; Peter St George-Hyslop; Rong Cheng; Joseph H Lee; Pankaj D Mehta; Richard Mayeux
Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels.
Neurobiology of aging 2012;33(1):199.e13-7.
2011: Christiane B Knobbe; Tak W Mak; Howard T J Mount; Timothy J Revett; Yu Bai; Christopher Böhm; Vinca Chow; Sepehr Ehsani; Amy Hye Won Jeon; Thomas Kislinger; Peter St George-Hyslop; Gerold Schmitt-Ulms
Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90.
Journal of proteome research 2011;10(10):4388-404.
2011: Jacqueline A Pettersen; Peter St George-Hyslop; David G Patry; Bernadette Curry
Variant Alzheimer disease with spastic paraparesis: a rare presenilin-1 mutation.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2011;38(4):659-61.
2011: Dun-Sheng Yang; Urmi Bandyopadhyay; Ana Maria Cuervo; Ying Jiang; Susmita Kaushik; Asok Kumar; Efrat Levy; Paul M Mathews; Panaiyur S Mohan; Masuo Ohno; Monika Pawlik; Corrinne M Peterhoff; Stephen D Schmidt; Peter St George-Hyslop; Philip Stavrides; Daniel W Wesson; David Westaway; Donald A Wilson; Austin Yang; Ralph A. Nixon
Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.
Autophagy 2011;7(7):788-9.
2011: Adam C Naj; Gyungah Jun; Gary Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew Huentelman; Amanda Myers; M. Michael Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Steven E Arnold; Robert C Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; dennis dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas Galasko; Mary Ganguli; Marla Gearing; Daniel Geschwind; Bernardino Ghetti; John Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C. Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret Pericak-Vance; Lindsay A Farrer; Peter St George-Hyslop; Gerard D Schellenberg
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Nature genetics 2011;43(5):436-41.
2011: Sepehr Ehsani; Hairu Huo; Ashkan Salehzadeh; Cosmin L Pocanschi; Joel C Watts; Holger Wille; David Westaway; Ekaterina Rogaeva; Peter St George-Hyslop; Gerold Schmitt-Ulms
Family reunion--the ZIP/prion gene family.
Progress in neurobiology 2011;93(3):405-20.
2011: Joseph H Lee; Rong Cheng; Sandra Barral; Christiane Reitz; Martin Medrano; Rafael Lantigua; Ivonne Z Jiménez-Velazquez; Ekaterina Rogaeva; Peter St George-Hyslop; Richard Mayeux
Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals.
Archives of neurology 2011;68(3):320-8.
2011: Christiane Reitz; Rong Cheng; Ekaterina Rogaeva; Joseph H Lee; Shinya Tokuhiro; Fanggeng Zou; Karolien Bettens; Kristel Sleegers; Eng King Tan; Ryo Kimura; Nobuto Shibata; Heii Arai; M Ilyas Kamboh; Jonathan A Prince; Wolfgang Maier; Matthias Riemenschneider; Michael J Owen; Denise Harold; Paul Hollingworth; Elena Cellini; Sandro Sorbi; Benedetta Nacmias; Masatoshi Takeda; Margaret Pericak-Vance; Jonathan L Haines; Steven G Younkin; Julie Williams; Christine Van Broeckhoven; Lindsay A Farrer; Peter St George-Hyslop; Richard Mayeux
Meta-analysis of the association between variants in SORL1 and Alzheimer disease.
Archives of neurology 2011;68(1):99-106.
2011: Dun-Sheng Yang; Philip Stavrides; Panaiyur S Mohan; Susmita Kaushik; Asok Kumar; Masuo Ohno; Stephen D Schmidt; Daniel Wesson; Urmi Bandyopadhyay; Ying Jiang; Monika Pawlik; Corrinne M Peterhoff; Austin Yang; Donald A Wilson; Peter St George-Hyslop; David Westaway; Paul M Mathews; Efrat Levy; Ana Maria Cuervo; Ralph A Nixon
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.
Brain : a journal of neurology 2011;134(Pt 1):258-77.
2010: Gyungah Jun; Adam C Naj; Gary Beecham; Li-San Wang; Jacqueline Buros; Paul J Gallins; Joseph Buxbaum; Nilufer Ertekin-Taner; MARGARET D FALLIN; Robert Friedland; Rivka Inzelberg; Patricia Kramer; Ekaterina Rogaeva; Peter St George-Hyslop; Laura B Cantwell; Beth A Dombroski; Andrew J Saykin; Eric Reiman; David A Bennett; John C Morris; Kathryn L Lunetta; Eden R Martin; Thomas J Montine; Alison Goate; Deborah Blacker; Debby W Tsuang; Duane Beekly; L Adrienne Cupples; Hakon Hakonarson; Walter Kukull; Tatiana M Foroud; Jonathan Haines; Richard Mayeux; Lindsay A Farrer; Margaret Pericak-Vance; Gerard D Schellenberg
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
Archives of neurology 2010;67(12):1473-84.
2010: Nobuo Sanjo; Taiichi Katayama; Hiroshi Hasegawa; Haifeng Jin; Monika Duthie; Howard T J Mount; Hidehiro Mizusawa; Peter St George-Hyslop; Paul E Fraser
Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related gamma-secretase.
Neuroscience letters 2010;483(1):53-6.
2010: Peter St George-Hyslop; Gerold Schmitt-Ulms
Alzheimer's disease: Selectively tuning gamma-secretase.
Nature 2010;467(7311):36-7.
2010: Rachel Butler; B Lynn Beattie; Umamon Puang Thong; Emily Dwosh; Colleen Guimond; Howard H Feldman; Ging-Yuek Robin Hsiung; Ekaterina Rogaeva; Peter St George-Hyslop; A Dessa Sadovnick
A novel PS1 gene mutation in a large Aboriginal kindred.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2010;37(3):359-64.
2010: Dylan G Harwood; Ari D Kalechstein; Warren W Barker; Silvia Strauman; Peter St George-Hyslop; Casandra Iglesias; David A Loewenstein; Ranjan Duara
The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer's disease.
International journal of geriatric psychiatry 2010;25(5):511-8.
2010: Soong Ho Kim; Paul E Fraser; David Westaway; Peter St George-Hyslop; Michelle E Ehrlich; Sam Gandy
Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(11):3870-5.
2010: A C Bruni; L Bernardi; R Colao; E Rubino; N Smirne; F Frangipane; B Terni; S A M Curcio; M Mirabelli; A Clodomiro; R Di Lorenzo; R Maletta; M Anfossi; M Gallo; S Geracitano; C Tomaino; M G Muraca; A Leotta; S G Lio; L Pinessi; I Rainero; Sandro Sorbi; L Nee; G Milan; S Pappatà; A Postiglione; N Abbamondi; G Forloni; Peter St George-Hyslop; E Rogaeva; O Bugiani; G Giaccone; J F Foncin; Maria Grazia Spillantini; G Puccio
Worldwide distribution of PSEN1 Met146Leu mutation: a large variability for a founder mutation.
Neurology 2010;74(10):798-806.
2010: Antonio Orlacchio; Carla Babalini; Antonella Borreca; Clarice Patrono; Roberto Massa; Sarenur Basaran; Renato P Munhoz; Ekaterina A Rogaeva; Peter St George-Hyslop; Giorgio Bernardi; Toshitaka Kawarai
SPATACSIN mutations cause autosomal recessive juvenile amyotrophic lateral sclerosis.
Brain : a journal of neurology 2010;133(Pt 2):591-8.
2010: Daniel A Pollen; Stephen Baker; Douglas Hinerfeld; Joan Swearer; Barbara A Evans; James E Evans; Richard Caselli; Ekaterina Rogaeva; Peter St George-Hyslop; Majaz Moonis
Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4.
Alzheimer's research & therapy 2010;2(5):31.
2010: Tomasz Gabryelewicz; Mario Masellis; Mariusz Berdynski; Juan M Bilbao; Ekaterina Rogaeva; Peter St George-Hyslop; Anna Barczak; Krzysztof Czyzewski; Maria Barcikowska; Zbigniew Wszolek; Sandra E Black; Cezary Zekanowski
Intra-familial clinical heterogeneity due to FTLD-U with TDP-43 proteinopathy caused by a novel deletion in progranulin gene (PGRN).
Journal of Alzheimer's disease : JAD 2010;22(4):1123-33.
2010: Haifeng Jin; Nobuo Sanjo; Toshiki Uchihara; Kazuhiko Watabe; Peter St George-Hyslop; Paul E Fraser; Hidehiro Mizusawa
Presenilin-1 holoprotein is an interacting partner of sarco endoplasmic reticulum calcium-ATPase and confers resistance to endoplasmic reticulum stress.
Journal of Alzheimer's disease : JAD 2010;20(1):261-73.
2009: Raphaëlle Pardossi-Piquard; Christopher Böhm; Fusheng Chen; Soshi Kanemoto; Frédéric Checler; Gerold Schmitt-Ulms; Peter St George-Hyslop; Paul E Fraser
TMP21 transmembrane domain regulates gamma-secretase cleavage.
The Journal of biological chemistry 2009;284(42):28634-41.
2009: Mary C Tierney; Paul Oh; Rahim Moineddin; Ellen M Greenblatt; W Gary Snow; Rory H Fisher; John Iazzetta; Peter St George-Hyslop; Neil J MacLusky
A randomized double-blind trial of the effects of hormone therapy on delayed verbal recall in older women.
Psychoneuroendocrinology 2009;34(7):1065-74.
2009: Raphaëlle Pardossi-Piquard; Seung-Pil Yang; Soshi Kanemoto; Yongjun Gu; Fusheng Chen; Christopher Böhm; Jean Sevalle; Tong Li; Philip C Wong; Frédéric Checler; Gerold Schmitt-Ulms; Peter St George-Hyslop; Paul E Fraser
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes.
The Journal of biological chemistry 2009;284(24):16298-307.
2009: Bruno Vincent; Claire Sunyach; Hans-Dieter Orzechowski; Peter St George-Hyslop; Frédéric Checler
p53-Dependent transcriptional control of cellular prion by presenilins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(20):6752-60.
2009: Richard Mayeux; Peter St George-Hyslop
Brain traffic: subcellular transport of the amyloid precursor protein.
Archives of neurology 2009;66(4):433-4.
2009: Raphaëlle Pardossi-Piquard; Julie Dunys; Emilie Giaime; Marie-Victoire Guillot-Sestier; Peter St George-Hyslop; Cristine Alves da Costa; Cristine Alves da Costa
p53-dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex.
Journal of neurochemistry 2009;109(1):225-37.
2009: Steve Pedrini; Carlos Thomas; Hannah Brautigam; James Schmeidler; Lap Ho; Paul E Fraser; David Westaway; Peter St George-Hyslop; Ralph N Martins; Joseph Buxbaum; Giulio M Pasinetti; Dara L Dickstein; Patrick R Hof; Michelle E Ehrlich; Sam Gandy
Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology.
Molecular neurodegeneration 2009;4():40.
2009: Barbara A Evans; James E Evans; Stephen P Baker; Kevin Kane; Joan Swearer; Douglas Hinerfeld; Richard Caselli; Ekaterina Rogaeva; Peter St George-Hyslop; Majaz Moonis; Daniel A Pollen
Long-term statin therapy and CSF cholesterol levels: implications for Alzheimer's disease.
Dementia and geriatric cognitive disorders 2009;27(6):519-24.
2008: Karen T Cuenco; Kathryn L Lunetta; Clinton T Baldwin; Ann C McKee; Jianping Guo; L Adrienne Cupples; Robert C Green; Peter St George-Hyslop; Helena Chui; Charles DeCarli; Lindsay A Farrer
Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease.
Archives of neurology 2008;65(12):1640-8.
2008: Irfan Y Tamboli; Kai Prager; Dietmar R Thal; Karin M Thelen; Ilse Dewachter; Claus U Pietrzik; Peter St George-Hyslop; Sangram S Sisodia; Bart De Strooper; Michael T Heneka; Mikhail A Filippov; Ulrike Müller; Fred Van Leuven; Dieter Lütjohann; Jochen Walter
Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(46):12097-106.
2008: S G Lindquist; L Hasholt; J M C Bahl; N H H Heegaard; Birgitte Bo Andersen; A Nørremølle; Jette Stokholm; M Schwartz; M Batbayli; H Laursen; R Pardossi-Piquard; F Chen; Peter St George-Hyslop; Gunhild Waldemar; J E Nielsen
A novel presenilin 2 mutation (V393M) in early-onset dementia with profound language impairment.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2008;15(10):1135-9.
2008: Peter St George-Hyslop; John C Morris
Will anti-amyloid therapies work for Alzheimer's disease?
Lancet 2008;372(9634):180-2.
2008: Peter St George-Hyslop; Christian Haass
Regulatory RNA goes awry in Alzheimer's disease.
Nature medicine 2008;14(7):711-2.
2008: Virginia Dolcini; Julie Dunys; Jean Sevalle; Fusheng Chen; Marie-Victoire Guillot-Sestier; Peter St George-Hyslop; Paul E Fraser; Frédéric Checler
TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin.
Biochemical and biophysical research communications 2008;371(1):69-74.
2008: Atsushi Sasaki; Takeshi Kawarabayashi; Tetsuro Murakami; Etsuro Matsubara; Masaki Ikeda; Haruo Hagiwara; David Westaway; Peter St George-Hyslop; Mikio Shoji; Yoichi Nakazato
Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L.
Brain research 2008;1214():159-68.
2008: Jacqueline A Pettersen; Gayathri Sathiyamoorthy; Fu-Qiang Gao; Gregory Szilagyi; Neelesh K Nadkarni; Peter St George-Hyslop; Ekaterina Rogaeva; Sandra Black
Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study.
Archives of neurology 2008;65(6):790-5.
2008: Antonio Orlacchio; Ian Bruce; Proton Rahman; Toshitaka Kawarai; Giorgio Bernardi; Peter St George-Hyslop; Dafna D Gladman; Murray B Urowitz
The apolipoprotein E2 isoform is associated with accelerated onset of coronary artery disease in systemic lupus erythematosus.
Medical science monitor : international medical journal of experimental and clinical research 2008;14(5):CR233-237.
2008: Joseph Lee; Rong Cheng; Ekaterina Rogaeva; Yan Meng; Yaakov Stern; Vincent Santana; Rafael Lantigua; Martin Medrano; Ivonne Z Jimenez-Velazquez; Lindsay A Farrer; Peter St George-Hyslop; Richard Mayeux
Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease.
Neurogenetics 2008;9(2):127-38.
2008: Xiao-Qing Liu; Andrew D Paterson; Ning He; Peter St George-Hyslop; Virpi Rauta; Carola Gronhagen-Riska; Markku Laakso; Lise Thibaudin; François Berthoux; Daniel C Cattran; York Pei
IL5RA and TNFRSF6B gene variants are associated with sporadic IgA nephropathy.
Journal of the American Society of Nephrology : JASN 2008;19(5):1025-33.
2008: Joseph Lee; Sandra Barral; Rong Cheng; Inara Chacon; Vincent Santana; Jennifer Williamson; Rafael Lantigua; Martin Medrano; Ivonne Z Jimenez-Velazquez; Yaakov Stern; Benjamin Tycko; Ekaterina Rogaeva; Yosuke Wakutani; Toshitaka Kawarai; Peter St George-Hyslop; Richard Mayeux
Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer's disease.
Neurogenetics 2008;9(1):51-60.
2008: Richard Mayeux; Peter St George-Hyslop
Alzheimer's disease: advances in trafficking.
Lancet neurology 2008;7(1):2-3.
2008: Hao Li; Sally Wetten; Li Li; Pamela L St Jean; Ruchi Upmanyu; Linda Surh; David Hosford; Michael R Barnes; James David Briley; Michael Borrie; Natalie Coletta; Richard Delisle; Daniella Dhalla; Margaret G Ehm; Howard H Feldman; Luis Fornazzari; S Gauthier; Neil Goodgame; Danilo Guzman; Sandra Hammond; Paul Hollingworth; Ging-Yuek Hsiung; Joan Johnson; Devon D Kelly; Ron Keren; Andrew Kertesz; Karen S King; Simon Lovestone; Inge Loy-English; Paul Matthews; Michael J Owen; Mary Plumpton; William Pryse-Phillips; Rab Prinjha; Jill C Richardson; Ann M Saunders; Andrew J Slater; Peter St George-Hyslop; Sandra W Stinnett; Jina Swartz; Rachel L Taylor; John Wherrett; Julie Williams; David P Yarnall; Rachel A Gibson; Michael C Irizarry; Lefkos T Middleton; Allen D Roses
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.
Archives of neurology 2008;65(1):45-53.
2008: Yu Bai; Kelly Markham; Fusheng Chen; Rasanjala Weerasekera; Joel Watts; Patrick Horne; Yosuke Wakutani; Richard D Bagshaw; Paul Mathews; Paul E Fraser; David Westaway; Peter St George-Hyslop; Gerold Schmitt-Ulms
The in vivo brain interactome of the amyloid precursor protein.
Molecular & cellular proteomics : MCP 2008;7(1):15-34.
2007: Raphaëlle Pardossi-Piquard; Fusheng Chen; Nancy F Silva-Gagliardi; Michael Szego; Roderick McInnes; C Jane McGlade; Peter St George-Hyslop; Paul E Fraser
Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells.
Biochemistry 2007;46(48):13704-10.
2007: Yan Meng; Joseph Lee; Rong Cheng; Peter St George-Hyslop; Richard Mayeux; Lindsay A Farrer
Association between SORL1 and Alzheimer's disease in a genome-wide study.
Neuroreport 2007;18(17):1761-4.
2007: Douglas Hinerfeld; Majaz Moonis; Joan M Swearer; Stephen Baker; Richard Caselli; Ekaterina Rogaeva; Peter St George-Hyslop; Daniel A Pollen
Statins differentially affect amyloid precursor protein metabolism in presymptomatic PS1 and non-PS1 subjects.
Archives of neurology 2007;64(11):1672-3.
2007: Frédéric Checler; Claire Sunyach; Raphaëlle Pardossi-Piquard; Jean Sévalle; Bruno Vincent; Toshitaka Kawarai; Nadège Girardot; Peter St George-Hyslop; Cristine Alves da Costa
The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.
Current Alzheimer research 2007;4(4):423-6.
2007: Andrew D Paterson; Xiao-Qing Liu; Kairong Wang; riccardo magistroni; Xuewen Song; Joanne Kappel; Judith Klassen; Daniel C Cattran; Peter St George-Hyslop; York Pei
Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36.
Journal of the American Society of Nephrology : JASN 2007;18(8):2408-15.
2007: Tomoko Kurata; Takeshi Kawarabayashi; Tetsuro Murakami; Kazunori Miyazaki; Nobutoshi Morimoto; Yasuyuki Ohta; Yasushi Takehisa; Makiko Nagai; Masaki Ikeda; Etsuro Matsubara; David Westaway; Peter St George-Hyslop; Yasuo Harigaya; Tatsushi Kamiya; Mikio Shoji; Koji Abe
Enhanced accumulation of phosphorylated alpha-synuclein in double transgenic mice expressing mutant beta-amyloid precursor protein and presenilin-1.
Journal of neuroscience research 2007;85(10):2246-52.
2007: Amalia C Bruni; Parastoo Momeni; L Bernardi; Carmine Tomaino; F Frangipane; Joshua Elder; Toshitaka Kawarai; Christine Sato; S Pradella; Yosuke Wakutani; M Anfossi; M Gallo; S Geracitano; A Costanzo; Nicoletta Smirne; S A M Curcio; Maria Mirabelli; Gianfranco Puccio; Rosanna Colao; Raffaele Maletta; A Kertesz; Peter St George-Hyslop; John Hardy; Ekaterina Rogaeva
Heterogeneity within a large kindred with frontotemporal dementia: a novel progranulin mutation.
Neurology 2007;69(2):140-7.
2007: Masaru Matsui; Toshitaka Kawarai; Yoshiki Hase; Hidekazu Tomimoto; Kazumi Iseki; Ekaterina Rogaeva; Antonio Orlacchio; Giorgio Bernardi; Peter St George-Hyslop; Ryosuke Takahashi; Makoto Matsui
A novel mutation in the SPG3A gene (atlastin) in hereditary spastic paraplegia.
Journal of neurology 2007;254(7):972-4.
2007: Joseph Lee; Rong Cheng; Nicole Schupf; Jennifer Manly; Rafael Lantigua; Yaakov Stern; Ekaterina Rogaeva; Yosuke Wakutani; Lindsay A Farrer; Peter St George-Hyslop; Richard Mayeux
The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort.
Archives of neurology 2007;64(4):501-6.
2007: Raphaëlle Pardossi-Piquard; Julie Dunys; Toshitaka Kawarai; Claire Sunyach; Cristine Alves da Costa; Bruno Vincent; Jean Sévalle; Sanjay Pimplikar; Peter St George-Hyslop; Cristine Alves da Costa
Response to correspondence: Pardossi-Piquard et al., "Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betAAPP and APLP." Neuron 46, 541-554.
Neuron 2007;53(4):483-6.
2007: Ekaterina Rogaeva; Yan Meng; Joseph Lee; Yongjun Gu; Toshitaka Kawarai; Fanggeng Zou; Taiichi Katayama; Clinton T Baldwin; Rong Cheng; Hiroshi Hasegawa; Fusheng Chen; Nobuto Shibata; Kathryn L Lunetta; Raphaelle Pardossi-Piquard; Christopher Bohm; Yosuke Wakutani; L Adrienne Cupples; Karen T Cuenco; Robert C Green; Lorenzo Pinessi; Innocenzo Rainero; Sandro Sorbi; Amalia Bruni; Ranjan Duara; Robert P Friedland; Rivka Inzelberg; Wolfgang Hampe; Hideaki Bujo; You-Qiang Song; Olav M Andersen; Thomas E Willnow; Neill Graff-Radford; Ronald C. Petersen; dennis dickson; Sandy D Der; Paul E Fraser; Gerold Schmitt-Ulms; Steven G Younkin; Richard Mayeux; Lindsay A Farrer; Peter St George-Hyslop
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.
Nature genetics 2007;39(2):168-77.
2007: Sonya Brijbassi; Zareen Amtul; Susan Newbigging; David Westaway; Peter St George-Hyslop; Richard Rozmahel
Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
Neurobiology of disease 2007;25(2):291-6.
2007: Julie Dunys; Toshitaka Kawarai; Emilie Giaime; Sherwin Wilk; Magali Herrant; Patrick Auberger; Peter St George-Hyslop; Cristine Alves da Costa; Cristine Alves da Costa
Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2.
Neuro-degenerative diseases 2007;4(2-3):156-63.
2006: Joseph Lee; Rong Cheng; Vincent Santana; Jennifer Williamson; Rafael Lantigua; Martin Medrano; Alex Arriaga; Yaakov Stern; Benjamin Tycko; Ekaterina Rogaeva; Yosuke Wakutani; Toshitaka Kawarai; Peter St George-Hyslop; Richard Mayeux
Expanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer disease.
Archives of neurology 2006;63(11):1591-8.
2006: Mario Masellis; Parastoo Momeni; Wendy S Meschino; Reid Heffner; Joshua Elder; Christine Sato; Yan Liang; Peter St George-Hyslop; John Hardy; Juan Bilbao; Sandra Black; Ekaterina Rogaeva
Novel splicing mutation in the progranulin gene causing familial corticobasal syndrome.
Brain : a journal of neurology 2006;129(Pt 11):3115-23.
2006: Sabine Wislet-Gendebien; Cheryl A D'Souza; Toshitaka Kawarai; Peter St George-Hyslop; David Westaway; Paul E Fraser; Anurag Tandon
Cytosolic proteins regulate alpha-synuclein dissociation from presynaptic membranes.
The Journal of biological chemistry 2006;281(43):32148-55.
2006: Hans H Klünemann; Wolfgang Fronhöfer; Doris Werner-Füchtenbusch; Eva Grasbon-Frodl; Stefan Kloiber; Herbert W Wurster; Peter St George-Hyslop; Ekaterina Rogaeva
Characterization of the kindred of Alois Alzheimer's patient with plaque-only dementia.
Alzheimer disease and associated disorders 2006;20(4):291-4.
2006: Muhammad A Chishti; Saeed Bohlega; Maqbool Ahmed; Arslan Loualich; Pamela Carroll; Christine Sato; Peter St George-Hyslop; David Westaway; Ekaterina Rogaeva
T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease.
Archives of neurology 2006;63(10):1483-5.
2006: Tetsuro Murakami; Erwan Paitel; Takeshi Kawarabayashi; Masaki Ikeda; M Azhar Chishti; Christopher Janus; Etsuro Matsubara; Atsushi Sasaki; Toshitaka Kawarai; Amie L Phinney; Yasuo Harigaya; Patrick Horne; Nobuaki Egashira; Kenichi Mishima; Amanda Hanna; Jing Yang; Katsunori Iwasaki; Mitsuo Takahashi; Michihiro Fujiwara; Koichi Ishiguro; Catherine Bergeron; George A Carlson; Koji Abe; David Westaway; Peter St George-Hyslop; Mikio Shoji
Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.
The American journal of pathology 2006;169(4):1365-75.
2006: Braydon L Burgess; Sean A McIsaac; Kathryn E Naus; Jeniffer Y Chan; Gavin H Tansley; Jing Yang; Fudan Miao; Colin J D Ross; Miranda van Eck; Michael R Hayden; William E Van Nostrand; Peter St George-Hyslop; David Westaway; Cheryl L Wellington
Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma.
Neurobiology of disease 2006;24(1):114-27.
2006: Satoshi Kaneko; Toshitaka Kawarai; Edwin Yip; Shabnam Salehi-Rad; Christine Sato; Antonio Orlacchio; Giorgio Bernardi; Yan Liang; Hiroshi Hasegawa; Ekaterina Rogaeva; Peter St George-Hyslop
Novel SPG6 mutation p.A100T in a Japanese family with autosomal dominant form of hereditary spastic paraplegia.
Movement disorders : official journal of the Movement Disorder Society 2006;21(9):1531-3.
2006: Ekaterina Rogaeva; Cindy Zadikoff; Jonathan Ponesse; Gerold Schmitt-Ulms; Toshitaka Kawarai; Christine Sato; Shabnam Salehi-Rad; Peter St George-Hyslop; Anthony E Lang
Childhood onset in familial prion disease with a novel mutation in the PRNP gene.
Archives of neurology 2006;63(7):1016-21.
2006: JoAnne McLaurin; Meredith E Kierstead; Mary E Brown; Cheryl A Hawkes; Mark H L Lambermon; Amie L Phinney; Audrey A Darabie; Julian E Cousins; John French; Melissa F Lan; Fusheng Chen; Sydney S N Wong; Howard T J Mount; Paul E Fraser; David Westaway; Peter St George-Hyslop
Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.
Nature medicine 2006;12(7):801-8.
2006: Minh D To; Nalan Gokgoz; T G Doyle; DB Donoviel; Julia A Knight; Peter St George-Hyslop; alan bernstein; Irene L Andrulis
Functional characterization of novel presenilin-2 variants identified in human breast cancers.
Oncogene 2006;25(25):3557-64.
2006: Eriko Samura; Mikio Shoji; Takeshi Kawarabayashi; Atsushi Sasaki; Etsuro Matsubara; Tetsuro Murakami; Xu Wuhua; Shuta Tamura; Masaki Ikeda; Koich Ishiguro; Takaomi C Saido; David Westaway; Peter St George-Hyslop; Yasuo Harigaya; Koji Abe
Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1.
Brain research 2006;1094(1):192-9.
2006: Cristine Alves da Costa; Claire Sunyach; Raphaëlle Pardossi-Piquard; Jean Sévalle; Bruno Vincent; Nicole Boyer; Toshitaka Kawarai; Nadège Girardot; Peter St George-Hyslop; Cristine Alves da Costa
Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(23):6377-85.
2006: Cindy Zadikoff; Ekaterina Rogaeva; Ana Djarmati; Christine Sato; Shabnam Salehi-Rad; Peter St George-Hyslop; Christine Klein; Anthony E Lang
Homozygous and heterozygous PINK1 mutations: considerations for diagnosis and care of Parkinson's disease patients.
Movement disorders : official journal of the Movement Disorder Society 2006;21(6):875-9.
2006: Van Nguyen; Cynthia Hawkins; Catherine Bergeron; Agnes Supala; Jean Huang; David Westaway; Peter St George-Hyslop; Richard Rozmahel
Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.
Brain research 2006;1086(1):76-84.
2006: Raphaëlle Pardossi-Piquard; Julie Dunys; Gang G. Yu; Peter St George-Hyslop; Cristine Alves da Costa; Frédéric Checler
Neprilysin activity and expression are controlled by nicastrin.
Journal of neurochemistry 2006;97(4):1052-6.
2006: L Bernardi; Raffaele Maletta; Carmine Tomaino; Nicoletta Smirne; Manuela Di Natale; M Perri; T Longo; Rosanna Colao; S A M Curcio; Gianfranco Puccio; Maria Mirabelli; Toshitaka Kawarai; Ekaterina Rogaeva; Peter St George-Hyslop; Giuseppe Passarino; G De Benedictis; Amalia C Bruni
The effects of APOE and tau gene variability on risk of frontotemporal dementia.
Neurobiology of aging 2006;27(5):702-9.
2006: Fusheng Chen; Hiroshi Hasegawa; Gerold Schmitt-Ulms; Toshitaka Kawarai; Christopher Bohm; Taiichi Katayama; Yongjun Gu; Nobuo Sanjo; Michael Glista; Ekaterina Rogaeva; Yosuke Wakutani; Raphaëlle Pardossi-Piquard; Xueying Ruan; Anurag Tandon; Frédéric Checler; Philippe Marambaud; Kirk Hansen; David Westaway; Peter St George-Hyslop; Paul E Fraser
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Nature 2006;440(7088):1208-12.
2006: Julie Dunys; Toshitaka Kawarai; Sherwin Wilk; Peter St George-Hyslop; Cristine Alves da Costa; Frédéric Checler
Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins.
The Biochemical journal 2006;394(Pt 2):501-9.
2006: Renato P Munhoz; Toshitaka Kawarai; Hélio A G Teive; Salmo Raskin; Christine Sato; Yan Liang; Peter St George-Hyslop; Ekaterina Rogaeva
Clinical and genetic study of a Brazilian family with spastic paraplegia (SPG6 locus).
Movement disorders : official journal of the Movement Disorder Society 2006;21(2):279-81.
2006: Nobuto Shibata; Toshitaka Kawarai; Joseph Lee; Hye-Seung Lee; Eri Shibata; Christine Sato; Yan Liang; Ranjan Duara; Richard Mayeux; Peter St George-Hyslop; Ekaterina Rogaeva
Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.
Neuroscience letters 2006;391(3):142-6.
2006: Parastoo Momeni; Jennifer C Schymick; Shushant Jain; Mark Cookson; Nigel J Cairns; Elisa Greggio; Matthew J Greenway; Stephen Berger; Stuart Pickering-Brown; Adriano Chio; Hon-Chung Fung; David M Holtzman; Edward D Huey; Eric M Wassermann; Jennifer Adamson; Michael Hutton; Ekaterina Rogaeva; Peter St George-Hyslop; Jeffrey rothstein; Orla Hardiman; Jordan Grafman; Andrew Singleton; John Hardy; Bryan Joseph Traynor
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
BMC neurology 2006;6():44.
2006: Yan Li; Leung-Wing Chu; Y Q Chen; Bernard M Y Cheung; Raymond Y H Leung; Ping-Yiu Yik; K M Ng; W Mak; Dong-Yan Jin; Peter St George-Hyslop; You-Qiang Song
Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese patients.
Dementia and geriatric cognitive disorders 2006;22(5-6):399-404.
2006: Parastoo Momeni; Ekaterina Rogaeva; Vivianna M Van Deerlin; Wuxing Yuan; Jordan Grafman; Michael Tierney; Edward D Huey; Jason Bell; Christopher M Morris; Rajesh N. Kalaria; Susan J van Rensburg; Dana J H Niehaus; F C V Potocnik; Toshitaka Kawarai; Shabnam Salehi-Rad; Christine Sato; Peter St George-Hyslop; John Hardy
Genetic variability in CHMP2B and frontotemporal dementia.
Neuro-degenerative diseases 2006;3(3):129-33.
2006: Toshiki Uchihara; Nobuo Sanjo; Ayako Nakamura; Kyung Han; Si-Young Song; Peter St George-Hyslop; Paul E Fraser
Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum.
Neurobiology of aging 2006;27(1):88-97.
2005: Agnes Petit; Toshitaka Kawarai; Erwan Paitel; Nobuo Sanjo; Mary Maj; Michael Scheid; Fusheng Chen; Yongjun Gu; Hiroshi Hasegawa; Shabnam Salehi-Rad; Linda Wang; Ekaterina Rogaeva; Paul E Fraser; Brian Robinson; Peter St George-Hyslop; Anurag Tandon
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations.
The Journal of biological chemistry 2005;280(40):34025-32.
2005: Coro Paisan-Ruiz; Anthony E Lang; Toshitaka Kawarai; Christine Sato; Shabnam Salehi-Rad; G K Fisman; T Al-Khairallah; Peter St George-Hyslop; Andrew Singleton; Ekaterina Rogaeva
LRRK2 gene in Parkinson disease: mutation analysis and case control association study.
Neurology 2005;65(5):696-700.
2005: Paul Tuite; H Brent Clark; Catherine Bergeron; Matthew Bower; Peter St George-Hyslop; Vesselina Mateva; John Anderson; David S. Knopman
Clinical and pathologic evidence of corticobasal degeneration and progressive supranuclear palsy in familial tauopathy.
Archives of neurology 2005;62(9):1453-7.
2005: Antonio Orlacchio; Toshitaka Kawarai; Fabrizio Gaudiello; Peter St George-Hyslop; Roberto Floris; Giorgio Bernardi
New locus for hereditary spastic paraplegia maps to chromosome 1p31.1-1p21.1.
Annals of neurology 2005;58(3):423-9.
2005: Antonio Orlacchio; Toshitaka Kawarai; Fabrizio Gaudiello; Antonio Totaro; Orazio Schillaci; Alessandro Stefani; Roberto Floris; Peter St George-Hyslop; Sandro Sorbi; Giorgio Bernardi
Clinical and genetic study of a large SPG4 Italian family.
Movement disorders : official journal of the Movement Disorder Society 2005;20(8):1055-9.
2005: Majaz Moonis; Joan M Swearer; M P E Dayaw; Peter St George-Hyslop; Ekaterina Rogaeva; T Kawarai; Daniel A Pollen
Familial Alzheimer disease: decreases in CSF Abeta42 levels precede cognitive decline.
Neurology 2005;65(2):323-5.
2005: Cristine Alves da Costa; Checler Frédéric; Cristine Alves da Costa; Alves da Costa Cristine; Erwan Ayral; Ayral Erwan; David Andrau; Andrau David; Cécile Dumanchin; Dumanchin Cécile; Michael Farzan; Farzan Michael; Jean-François Hernandez; Hernandez Jean-François; J Martinez; Solveig Lefranc-Jullien; Lefranc-Jullien Solveig; Philippe Marambaud; Marambaud Philippe; Andrea Pasini; Pasini Andrea; Agnès Petit; Petit Agnès; Christopher Phiel; Phiel Christopher; Philippe Robert; Robert Philippe; Peter St George-Hyslop; St George-Hyslop Peter; Sherwin Wilk; Wilk Sherwin
JLK inhibitors: isocoumarin compounds as putative probes to selectively target the gamma-secretase pathway.
Current Alzheimer research 2005;2(3):327-34.
2005: Peter Mastrangelo; Paul Mathews; M Azhar Chishti; Stephen D Schmidt; Yongjun Gu; Jing Yang; Matthew J Mazzella; Janaky Coomaraswamy; Patrick Horne; Bob Strome; Heather Pelly; Georges Levesque; Christine Ebeling; Ying Jiang; Ralph A. Nixon; Richard Rozmahel; Paul E Fraser; Peter St George-Hyslop; George A Carlson; David Westaway
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(25):8972-7.
2005: Raphaëlle Pardossi-Piquard; Agnès Petit; Toshitaka Kawarai; Claire Sunyach; Cristine Alves da Costa; Bruno Vincent; Sabine Ring; Luciano D'Adamio; Jie Shen; Ulrike Müller; Peter St George-Hyslop; Cristine Alves da Costa
Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.
Neuron 2005;46(4):541-54.
2005: Yoshifumi Nakaya; Takuya Yamane; Hirohisa Shiraishi; Hua-Qin Wang; Etsuro Matsubara; Toru Sato; Georgia Dolios; Rong Wang; Bart De Strooper; Mikio Shoji; Hiroto Komano; Katsuhiko Yanagisawa; Yasuo Ihara; Paul E Fraser; Peter St George-Hyslop; Masaki Nishimura
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.
The Journal of biological chemistry 2005;280(19):19070-7.
2005: Andrew D Paterson; riccardo magistroni; Ning He; Kairong Wang; Ann Johnson; Pamela R Fain; Elizabeth Dicks; Patrick Parfrey; Peter St George-Hyslop; York Pei
Progressive loss of renal function is an age-dependent heritable trait in type 1 autosomal dominant polycystic kidney disease.
Journal of the American Society of Nephrology : JASN 2005;16(3):755-62.
2005: Christine Sato; Angharad Morgan; Anthony E Lang; Shabnam Salehi-Rad; Toshitaka Kawarai; Yan Meng; Peter N Ray; Lindsay A Farrer; Peter St George-Hyslop; Ekaterina Rogaeva
Analysis of the glucocerebrosidase gene in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2005;20(3):367-70.
2005: Peter St George-Hyslop; Agnès Petit
Molecular biology and genetics of Alzheimer's disease.
Comptes rendus biologies 2005;328(2):119-30.
2005: Masaki Ikeda; Mikio Shoji; Toshitaka Kawarai; Takeshi Kawarabayashi; Etsuro Matsubara; Tetsuro Murakami; Atsushi Sasaki; Yasushi Tomidokoro; Yasushi Ikarashi; Hisashi Kuribara; Koichi Ishiguro; Masato Hasegawa; Shu-Hui C. Yen; M Azhar Chishti; Yasuo Harigaya; Koji Abe; Koichi Okamoto; Peter St George-Hyslop; David Westaway
Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice.
The American journal of pathology 2005;166(2):521-31.
2005: T Edwards-Lee; John M Ringman; J Chung; John S Werner; A Morgan; Peter St George-Hyslop; P Thompson; R Dutton; A Mlikotic; E Rogaeva; John Hardy
An African American family with early-onset Alzheimer disease and an APP (T714I) mutation.
Neurology 2005;64(2):377-9.
2005: Xiaodan Tian; Roxana Cecal; JoAnne McLaurin; Marilena Manea; Raluca Stefanescu; Sandra Grau; Mona Harnasch; Sarah Amir; Michael Ehrmann; Peter St George-Hyslop; Markus Kohlmann; Michael Przybylski
Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry.
European journal of mass spectrometry (Chichester, England) 2005;11(5):547-56.
2004: Justus L Groen; Toshitaka Kawarai; Anna Toulina; Chiara Rivoiro; Shabnam Salehi-Rad; Christine Sato; Angharad Morgan; Yan Liang; Ronald B Postuma; Peter St George-Hyslop; Anthony E Lang; Ekaterina Rogaeva
Genetic association study of PINK1 coding polymorphisms in Parkinson's disease.
Neuroscience letters 2004;372(3):226-9.
2004: A C Bruni; T Kawarai; Maria Grazia Spillantini; Peter St George-Hyslop; Attilio Leotta; S Lio; Jean Francois Foncin; Khalid H El Hachimi
[Familial fronto-temporal dementia with brain stem ubiquitin-positive neuronal inclusions].
Revue neurologique 2004;160(12):1171-9.
2004: Ekaterina Rogaeva; Janel Johnson; Anthony E Lang; Cindy Gulick; Katrina Gwinn-Hardy; Toshitaka Kawarai; Christine Sato; Angharad Morgan; John Werner; Robert L Nussbaum; Agnes Petit; Michael S Okun; Aideen McInerney; Ronald Mandel; Justus L Groen; Hubert H Fernandez; Ronald B Postuma; Kelly D Foote; Shabnam Salehi-Rad; Yan Liang; Sharon Reimsnider; Anurag Tandon; John Hardy; Peter St George-Hyslop; Andrew Singleton
Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease.
Archives of neurology 2004;61(12):1898-904.
2004: Hiroshi Hasegawa; Nobuo Sanjo; Fusheng Chen; Yong-Jun Gu; Cortney Shier; Agnes Petit; Toshitaka Kawarai; Taiichi Katayama; Stephen D Schmidt; Paul Mathews; Gerold Schmitt-Ulms; Paul E Fraser; Peter St George-Hyslop
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.
The Journal of biological chemistry 2004;279(45):46455-63.
2004: Joseph Lee; Richard Mayeux; David Mayo; J Mo; Vincent Santana; Jennifer Williamson; Antonia Flaquer; Alejandra Ciappa; Haydee Z Rondon; Pedro Estevez; Rafael Lantigua; Toshitaka Kawarai; Anna Toulina; Martin Medrano; Mayobanex Torres; Yaakov Stern; Benjamin Tycko; Ekaterina Rogaeva; Peter St George-Hyslop; James A Knowles
Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics.
Molecular psychiatry 2004;9(11):1042-51.
2004: David S Gelinas; Kevin A DaSilva; Daniela Fenili; Peter St George-Hyslop; JoAnne McLaurin
Immunotherapy for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101 Suppl 2():14657-62.
2004: Troy L Carter; Giuseppe Verdile; David M Groth; Alexey Bogush; Stefani N Thomas; Patrick Shen; Paul E Fraser; Paul Mathews; Ralph A. Nixon; Michelle E Ehrlich; John B J Kwok; Peter St George-Hyslop; Peter Schofield; Yueming Li; Austin Yang; Ralph N Martins; Sam Gandy
Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells.
Alzheimer disease and associated disorders 2004;18(4):261-3.
2004: Hans H Klünemann; Ekaterina Rogaeva; Manuela Neumann; Hans A Kretzschmar; Michael Kandel; Anna Toulina; Christine Sato; Shabnam Salehi-Rad; Karin Pfister; Helmfried E Klein; Peter St George-Hyslop
Novel PS1 mutation in a Bavarian kindred with familial Alzheimer disease.
Alzheimer disease and associated disorders 2004;18(4):256-8.
2004: Jian-Guo Cui; Paul E Fraser; Peter St George-Hyslop; David Westaway; Walter J Lukiw
Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression.
Neuroreport 2004;15(13):2025-8.
2004: Dylan G Harwood; Warren W Barker; Raymond Ownby; Peter St George-Hyslop; Michael Mullan; Ranjan Duara
Apolipoprotein E polymorphism and age of onset for Alzheimer's disease in a bi-ethnic sample.
International psychogeriatrics / IPA 2004;16(3):317-26.
2004: Cristine Alves da Costa; Erwan Ayral; Jean-François Hernandez; Peter St George-Hyslop; Cristine Alves da Costa
Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.
Journal of neurochemistry 2004;90(4):800-6.
2004: Yongjun Gu; Nobuo Sanjo; Fusheng Chen; Hiroshi Hasegawa; Agnes Petit; Xueying Ruan; Wenping Li; Cortney Shier; Toshitaka Kawarai; Gerold Schmitt-Ulms; David Westaway; Peter St George-Hyslop; Paul E Fraser
The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities.
The Journal of biological chemistry 2004;279(30):31329-36.
2004: Antonio Orlacchio; Toshitaka Kawarai; Mario Polidoro; Andrew D Paterson; Ekaterina Rogaeva; Aldo Orlacchio; Peter St George-Hyslop; Giorgio Bernardi
Lack of association between Alzheimer's disease and the promoter region polymorphisms of the nicastrin gene.
Neuroscience letters 2004;363(1):49-53.
2004: Antonio Orlacchio; Toshitaka Kawarai; Antonio Totaro; Alessia Errico; Peter St George-Hyslop; Elena I Rugarli; Giorgio Bernardi
Hereditary spastic paraplegia: clinical genetic study of 15 families.
Archives of neurology 2004;61(6):849-55.
2004: Giuseppe Verdile; David M Groth; Paul Mathews; Peter St George-Hyslop; Paul E Fraser; T V Ramabhadran; John B J Kwok; Peter R Schofield; T Carter; Sam Gandy; Ralph N Martins
Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells.
Molecular psychiatry 2004;9(6):594-602.
2004: Antonio Orlacchio; Fabrizio Gaudiello; Antonio Totaro; Roberto Floris; Peter St George-Hyslop; Giorgio Bernardi; Toshitaka Kawarai
A new SPG4 mutation in a variant form of spastic paraplegia with congenital arachnoid cysts.
Neurology 2004;62(10):1875-8.
2004: Vanya Peltekova; Richard F Wintle; Laurence A Rubin; Christopher I Amos; Qiqing Huang; Xiangjun Gu; Bill Newman; Mark Van Oene; David Cescon; Gordon Greenberg; Anne M Griffiths; Peter St George-Hyslop; Katherine A Siminovitch
Functional variants of OCTN cation transporter genes are associated with Crohn disease.
Nature genetics 2004;36(5):471-5.
2004: Sam Gandy; Ron B DeMattos; Cynthia A Lemere; Frank L Heppner; Jodi Leverone; Adriano Aguzzi; William B. Ershler; Jinlu Dai; Paul E Fraser; Peter St George-Hyslop; David M Holtzman; Lary Walker; Evan T Keller
Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta).
Mechanisms of ageing and development 2004;125(2):149-51.
2004: Cheryl A Luis; Warren W Barker; David A Loewenstein; Thomas A Crum; Ekaterina Rogaeva; Toshitaka Kawarai; Peter St George-Hyslop; Ranjan Duara
Conversion to dementia among two groups with cognitive impairment. A preliminary report.
Dementia and geriatric cognitive disorders 2004;18(3-4):307-13.
2004: Sam Gandy; Ron B DeMattos; Cynthia A Lemere; Frank L Heppner; Jodi Leverone; Adriano Aguzzi; William B. Ershler; Jinlu Dai; Paul E Fraser; Peter St George-Hyslop; David M Holtzman; Lary Walker; Evan T Keller
Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta).
Alzheimer disease and associated disorders 2004;18(1):44-6.
2003: Amie L Phinney; Bettina Drisaldi; Stephen D Schmidt; Stan Lugowski; Veronica Coronado; Yan Liang; Patrick Horne; Jing Yang; Joannis Sekoulidis; Janaky Coomaraswamy; M Azhar Chishti; Diane W Cox; Paul Mathews; Ralph A. Nixon; George A Carlson; Peter St George-Hyslop; David Westaway
In vivo reduction of amyloid-beta by a mutant copper transporter.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14193-8.
2003: James L Kennedy; Lindsay A Farrer; Nancy C Andreasen; Richard Mayeux; Peter St George-Hyslop
The genetics of adult-onset neuropsychiatric disease: complexities and conundra?
Science (New York, N.Y.) 2003;302(5646):822-6.
2003: Ekaterina Rogaeva; Catherine Bergeron; Christine Sato; I Moliaka; Toshitaka Kawarai; Anna Toulina; You-Qiang Song; T Kolesnikova; A Orlacchio; Giorgio Bernardi; Peter St George-Hyslop
PS1 Alzheimer's disease family with spastic paraplegia: the search for a gene modifier.
Neurology 2003;61(7):1005-7.
2003: Anurag Tandon; Haung Yu; Linda Wang; Ekaterina Rogaeva; Christine Sato; M Azhar Chishti; Toshitaka Kawarai; Hiroshi Hasegawa; Fusheng Chen; Peter Davies; Paul E Fraser; David Westaway; Peter St George-Hyslop
Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles.
Journal of neurochemistry 2003;86(3):572-81.
2003: Manuela Di Natale; Maria Perri; Toshitaka Kawarai; Raffaele Maletta; Carmine Tomaino; Christine Sato; Benedetta Nacmias; Nobuto Shibata; Sandro Sorbi; Peter St George-Hyslop; Amalia C Bruni; Ekaterina Rogaeva
Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population.
Neuroscience letters 2003;343(3):210-2.
2003: Fusheng Chen; Anurag Tandon; Nobuo Sanjo; Yong-Jun Gu; Hiroshi Hasegawa; Shigeki Arawaka; Frank J S Lee; Xueying Ruan; Peter Mastrangelo; Serap Erdebil; Linda Wang; David Westaway; Howard T J Mount; Bruce A Yankner; Paul E Fraser; Peter St George-Hyslop
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
The Journal of biological chemistry 2003;278(22):19974-9.
2003: Yongjun Gu; Fusheng Chen; Nobuo Sanjo; Toshitaka Kawarai; Hiroshi Hasegawa; Monika Duthie; Wenping Li; Xueying Ruan; Anchla Luthra; Howard T J Mount; Anurag Tandon; Paul E Fraser; Peter St George-Hyslop
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.
The Journal of biological chemistry 2003;278(9):7374-80.
2002: Jennifer Liauw; Van Nguyen; Jean Huang; Peter St George-Hyslop; Richard Rozmahel
Differential display analysis of presenilin 1-deficient mouse brains.
Brain research. Molecular brain research 2002;109(1-2):56-62.
2002: Shigeki Arawaka; Hiroshi Hasegawa; Anurag Tandon; Christopher Janus; Fusheng Chen; Gang G. Yu; Kenji Kikuchi; Shingo Koyama; Takeo Kato; Paul E Fraser; Peter St George-Hyslop
The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein.
Journal of neurochemistry 2002;83(5):1065-71.
2002: Antonio Orlacchio; Toshitaka Kawarai; Mario Polidoro; Alessandro Stefani; Aldo Orlacchio; Peter St George-Hyslop; Giorgio Bernardi
Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms.
Neuroscience letters 2002;333(2):115-8.
2002: JoAnne McLaurin; Roxana Cecal; M E Kierstead; X Tian; Amie L Phinney; Marilena Manea; J E French; Mark H L Lambermon; Audrey A Darabie; Mary E Brown; Christopher Janus; M Azhar Chishti; Patrick Horne; David Westaway; Paul E Fraser; Howard T J Mount; M Przybylski; Peter St George-Hyslop
Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.
Nature medicine 2002;8(11):1263-9.
2002: Richard Rozmahel; Howard T J Mount; Fusheng Chen; Van Nguyen; Jean Huang; Serap Erdebil; Jennifer Liauw; Gang G. Yu; Hiroshe Hasegawa; YongJun Gu; You-Qiang Song; Stephen D Schmidt; Ralph A. Nixon; Paul Mathews; Catherine Bergeron; Paul E Fraser; David Westaway; Peter St George-Hyslop
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14452-7.
2002: Fusheng Chen; YongJun Gu; Hiroshi Hasegawa; Xueying Ruan; Shigeki Arawaka; Paul E Fraser; David Westaway; Howard T J Mount; Peter St George-Hyslop
Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
The Journal of biological chemistry 2002;277(39):36521-6.
2002: Dun-Sheng Yang; Anurag Tandon; Fusheng Chen; Gang G. Yu; Haung Yu; Shigeki Arawaka; Hiroshi Hasegawa; Monika Duthie; Stephen D Schmidt; Triprayer V Ramabhadran; Ralph A. Nixon; Paul Mathews; Sam Gandy; Howard T J Mount; Peter St George-Hyslop; Paul E Fraser
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.
The Journal of biological chemistry 2002;277(31):28135-42.
2002: S A M Curcio; Toshitaka Kawarai; A D Paterson; Raffaele Maletta; Gianfranco Puccio; M Perri; Manuela Di Natale; S Palermo; Jean Francois Foncin; Peter St George-Hyslop; Amalia C Bruni
A large Calabrian kindred segregating frontotemporal dementia.
Journal of neurology 2002;249(7):911-22.
2002: Andrew D Paterson; Kai Rong Wang; Doina Lupea; Peter St George-Hyslop; York Pei
Recurrent fetal loss associated with bilineal inheritance of type 1 autosomal dominant polycystic kidney disease.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2002;40(1):16-20.
2002: Antonio Orlacchio; Toshitaka Kawarai; Eleonora Paciotti; Alessandro Stefani; Aldo Orlacchio; Sandro Sorbi; Peter St George-Hyslop; Giorgio Bernardi
Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease.
Neuroscience letters 2002;325(1):13-6.
2002: Shinjiro Fukami; Kaori Watanabe; Nobuhisa Iwata; Jo Haraoka; Bao Lu; Norma P Gerard; Craig Gerard; Paul E Fraser; David Westaway; Peter St George-Hyslop; Takaomi C Saido
Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.
Neuroscience research 2002;43(1):39-56.
2002: Sangram S Sisodia; Peter St George-Hyslop
gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?
Nature reviews. Neuroscience 2002;3(4):281-90.
2002: Richard Rozmahel; Jean Huang; Fusheng Chen; Yan Liang; Van Nguyen; Masaki Ikeda; Georges Levesque; Gang G. Yu; M Nishimura; Paul Mathews; Stephen D Schmidt; Marc Mercken; Catherine Bergeron; David Westaway; Peter St George-Hyslop
Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.
Neurobiology of aging 2002;23(2):187-94.
2002: Agnès Petit; Peter St George-Hyslop; Paul E Fraser; Frédéric Checler
Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells.
Biochemical and biophysical research communications 2002;290(5):1408-10.
2002: Euijung Jo; Nola L Fuller; Richard Rand; Peter St George-Hyslop; Paul E Fraser
Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein.
Journal of molecular biology 2002;315(4):799-807.
2002: Kevin Taddei; C Fisher; Simon Laws; Georgia Martins; Athena Paton; Roger Clarnette; C Chung; William S Brooks; Joachim Hallmayer; Judith Miklossy; Norman Richard Relkin; Peter St George-Hyslop; Sam Gandy; Ralph N Martins
Association between presenilin-1 Glu318Gly mutation and familial Alzheimer's disease in the Australian population.
Molecular psychiatry 2002;7(7):776-81.
2001: Eleni S Athan; Jennifer Williamson; Alejandra Ciappa; Vincent Santana; Stavra N Romas; Joseph Lee; Haydee Z Rondon; Rafael Lantigua; Martin Medrano; Mayobanex Torres; Shigeki Arawaka; Ekaterina Rogaeva; You-Qiang Song; Christine Sato; Toshitaka Kawarai; K C Fafel; MA Boss; William K Seltzer; Yaakov Stern; Peter St George-Hyslop; Benjamin Tycko; Richard Mayeux
A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families.
JAMA : the journal of the American Medical Association 2001;286(18):2257-63.
2001: Fusheng Chen; Gang G. Yu; Shigeki Arawaka; M Nishimura; Toshitaka Kawarai; Haung Yu; Anurag Tandon; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; P Milman; Christine Sato; C Yu; Christopher Janus; J Lee; L Song; Liyong Zhang; Paul E Fraser; Peter St George-Hyslop
Nicastrin binds to membrane-tethered Notch.
Nature cell biology 2001;3(8):751-4.
2001: Naoyuki Sato; Kazunori Imaizumi; Takayuki Manabe; Manabu Taniguchi; Junichi Hitomi; Taiichi Katayama; Toshiyuki Yoneda; Takashi Morihara; Yuichi Yasuda; T Takagi; Takashi Kudo; Takeo Tsuda; Yasuto Itoyama; T Makifuchi; Paul E Fraser; Peter St George-Hyslop; Masaya Tohyama
Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2.
The Journal of biological chemistry 2001;276(3):2108-14.
2001: Paul E Fraser; Gang G. Yu; L Lévesque; M Nishimura; Dun-Sheng Yang; Howard T J Mount; David Westaway; Peter St George-Hyslop
Presenilin function: connections to Alzheimer's disease and signal transduction.
Biochemical Society symposium 2001;(67):89-100.
2001: D A Grimes; D Bulman; Peter St George-Hyslop; Anthony E Lang
Inherited myoclonus-dystonia: evidence supporting genetic heterogeneity.
Movement disorders : official journal of the Movement Disorder Society 2001;16(1):106-10.
2000: Christopher Janus; J Pearson; JoAnne McLaurin; Paul Mathews; Y Jiang; Stephen D Schmidt; M Azhar Chishti; Patrick Horne; D Heslin; J French; Howard T J Mount; Ralph A. Nixon; Marc Mercken; Catherine Bergeron; Paul E Fraser; Peter St George-Hyslop; David Westaway
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.
Nature 2000;408(6815):979-82.
2000: Carol F Lippa; Victoria Zhukareva; T Kawarai; Kunihiro Uryu; M Shafiq; Linda E Nee; J Grafman; Y Liang; Peter St George-Hyslop; John Q Trojanowski; Virginia M-Y Lee
Frontotemporal dementia with novel tau pathology and a Glu342Val tau mutation.
Annals of neurology 2000;48(6):850-8.
2000: Peter St George-Hyslop
Piecing together Alzheimer's.
Scientific American 2000;283(6):76-83.
2000: Fusheng Chen; Dun-Sheng Yang; Suzana Petanceska; Austin Yang; Anurag Tandon; Gang G. Yu; Richard Rozmahel; Jorge Ghiso; M Nishimura; DM Zhang; Toshitaka Kawarai; Georges Levesque; J Mills; L Levesque; You-Qiang Song; Ekaterina Rogaeva; David Westaway; Howard T J Mount; Sam Gandy; Peter St George-Hyslop; Paul E Fraser
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
The Journal of biological chemistry 2000;275(47):36794-802.
2000: mariagrazia grilli; E Diodato; Gianluca Lozza; Rossella Brusa; M Casarini; Daniela Uberti; Richard Rozmahel; David Westaway; Peter St George-Hyslop; Maurizio Memo; Ennio Ongini
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12822-7.
2000: Euijung Jo; JoAnne McLaurin; Christopher M Yip; Peter St George-Hyslop; Paul E Fraser
alpha-Synuclein membrane interactions and lipid specificity.
The Journal of biological chemistry 2000;275(44):34328-34.
2000: Peter St George-Hyslop
Alzheimer's disease.
Neurobiology of disease 2000;7(5):546-8.
2000: Gayatri Devi; A Fotiou; D Jyrinji; Benjamin Tycko; S DeArmand; Ekaterina Rogaeva; You-Qiang Song; H Medieros; Y Liang; A Orlacchio; Jennifer Williamson; Peter St George-Hyslop; Richard Mayeux
Novel presenilin 1 mutations associated with early onset of dementia in a family with both early-onset and late-onset Alzheimer disease.
Archives of neurology 2000;57(10):1454-7.
2000: DM Zhang; D Levitan; Gang G. Yu; M Nishimura; Fusheng Chen; Anurag Tandon; Toshitaka Kawarai; Shigeki Arawaka; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; Yan Liang; E Holmes; P Milman; Christine Sato; Liyong Zhang; Peter St George-Hyslop
Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans.
Neuroreport 2000;11(14):3227-30.
2000: Gang G. Yu; M Nishimura; Shigeki Arawaka; D Levitan; Liyong Zhang; Anurag Tandon; You-Qiang Song; Ekaterina Rogaeva; Fusheng Chen; Toshitaka Kawarai; Agnes Supala; L Levesque; Haung Yu; Dun-Sheng Yang; E Holmes; P Milman; Yan Liang; DM Zhang; D H Xu; Christine Sato; Evgeny I Rogaev; M Smith; Christopher Janus; Y Zhang; R Aebersold; Lindsay A Farrer; Sandro Sorbi; Amalia C Bruni; Paul E Fraser; Peter St George-Hyslop
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Nature 2000;407(6800):48-54.
2000: Carol F Lippa; Joan M Swearer; Kevin J Kane; David Nochlin; Thomas D Bird; Bernardino Ghetti; Linda E Nee; Peter St George-Hyslop; Daniel A Pollen; David Drachman
Familial Alzheimer's disease: site of mutation influences clinical phenotype.
Annals of neurology 2000;48(3):376-9.
2000: D Gestri; Cristina Cecchi; Andrea Tedde; Stefania Latorraca; A Orlacchio; E Grassi; A M Massaro; gianfranco liguri; Peter St George-Hyslop; Sandro Sorbi
Lack of SOD1 gene mutations and activity alterations in two Italian families with amyotrophic lateral sclerosis.
Neuroscience letters 2000;289(3):157-60.
2000: Anurag Tandon; Ekaterina Rogaeva; Michael Mullan; Peter St George-Hyslop
Molecular genetics of Alzheimer's disease: the role of beta-amyloid and the presenilins.
Current opinion in neurology 2000;13(4):377-84.
2000: Paul E Fraser; Dun-Sheng Yang; Gang G. Yu; L Lévesque; M Nishimura; Shigeki Arawaka; L C Serpell; Ekaterina Rogaeva; Peter St George-Hyslop
Presenilin structure, function and role in Alzheimer disease.
Biochimica et biophysica acta 2000;1502(1):1-15.
2000: Giuseppe Verdile; Ralph N Martins; Monika Duthie; E Holmes; Peter St George-Hyslop; Paul E Fraser
Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.
The Journal of biological chemistry 2000;275(27):20794-8.
2000: Geert Van Gassen; Chris De Jonghe; M Nishimura; Gang G. Yu; S Kuhn; Peter St George-Hyslop; Christine Van Broeckhoven
Evidence that the beta-catenin nuclear translocation assay allows for measuring presenilin 1 dysfunction.
Molecular medicine (Cambridge, Mass.) 2000;6(7):570-80.
2000: Christopher Janus; S D'Amelio; O Amitay; M Azhar Chishti; R Strome; Paul E Fraser; George A Carlson; John C Roder; Peter St George-Hyslop; David Westaway
Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes.
Neurobiology of aging 2000;21(4):541-9.
2000: Peter St George-Hyslop; J McLaurin; Paul E Fraser
Neuropathological, biochemical and genetic alterations in AD.
Drug news & perspectives 2000;13(5):281-8.
2000: Terry Watnick; Ning He; Kairong Wang; Y Liang; Patrick Parfrey; D Hefferton; Peter St George-Hyslop; Gregory G Germino; York Pei
Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations.
Nature genetics 2000;25(2):143-4.
2000: A Orlacchio; Toshitaka Kawarai; A M Massaro; Peter St George-Hyslop; Sandro Sorbi
Absence of linkage between familial amyotrophic lateral sclerosis and copper chaperone for the superoxide dismutase gene locus in two Italian pedigrees.
Neuroscience letters 2000;285(2):83-6.
2000: Andrew Kertesz; T Kawarai; E Rogaeva; Peter St George-Hyslop; Parvoneh Poorkaj-Navas; Thomas D Bird; David G Munoz
Familial frontotemporal dementia with ubiquitin-positive, tau-negative inclusions.
Neurology 2000;54(4):818-27.
2000: Peter St George-Hyslop
Molecular genetics of Alzheimer's disease.
Biological psychiatry 2000;47(3):183-99.
2000: Lindsay A Farrer; T Sherbatich; S A Keryanov; GI Korovaitseva; Ekaterina Rogaeva; S Petruk; S Premkumar; Yuri K Moliaka; You-Qiang Song; Y Pei; Christine Sato; ND Selezneva; S Voskresenskaya; Vera E Golimbet; Sandro Sorbi; Ranjan Duara; SI Gavrilova; Peter St George-Hyslop; Evgeny I Rogaev
Association between angiotensin-converting enzyme and Alzheimer disease.
Archives of neurology 2000;57(2):210-4.
2000: Gang G. Yu; Fusheng Chen; M Nishimura; H Steiner; Anurag Tandon; Toshitaka Kawarai; Shigeki Arawaka; Agnes Supala; You-Qiang Song; Ekaterina Rogaeva; E Holmes; DM Zhang; P Milman; Paul E Fraser; Christian Haass; Peter St George-Hyslop
Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.
Acta neurologica Scandinavica. Supplementum 2000;176():6-11.
2000: Peter St George-Hyslop
Genetic factors in the genesis of Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;924():1-7.
2000: Ricardo E Jorge; C Mangone; E Castano; C Perandones; Ekaterina Rogaeva; Peter St George-Hyslop; Khalid H El Hachimi; Jean Francois Foncin; Robert G Robinson; Amalia C Bruni
Comparison of clinical and pathological phenotypes in two ethnically and geographically unrelated pedigrees segregating an equivalent presenilin 1 mutation.
The Journal of neuropsychiatry and clinical neurosciences 2000;12(3):359-63.
1999: Taiichi Katayama; Kazunori Imaizumi; Naoyuki Sato; K Miyoshi; Takashi Kudo; Junichi Hitomi; Takashi Morihara; Toshiyuki Yoneda; Fumi Gomi; Yasuo Mori; Y Nakano; J Takeda; Takeo Tsuda; Yasuto Itoyama; Ohoshi Murayama; A Takashima; Peter St George-Hyslop; Masatoshi Takeda; Masaya Tohyama
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
Nature cell biology 1999;1(8):479-85.
1999: DB Donoviel; Anna-Katerina Hadjantonakis; Masaki Ikeda; Hong Zheng; Peter St George-Hyslop; alan bernstein
Mice lacking both presenilin genes exhibit early embryonic patterning defects.
Genes & development 1999;13(21):2801-10.
1999: H Miake; Kuniaki Tsuchiya; Ayako Nakamura; K Ikeda; L Levesque; Paul E Fraser; Peter St George-Hyslop; Hidehiro Mizusawa; Toshiki Uchihara
Glial expression of presenilin epitopes in human brain with cerebral infarction and in astrocytoma.
Acta neuropathologica 1999;98(4):337-40.
1999: L Lévesque; Willem ANNAERT; Katleen Craessaerts; Paul Mathews; M Seeger; Ralph A. Nixon; Fred Van Leuven; Sam Gandy; David Westaway; Peter St George-Hyslop; Bart De Strooper; Paul E Fraser
Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.
Molecular medicine (Cambridge, Mass.) 1999;5(8):542-54.
1999: Emily Van Uden; G Carlson; Peter St George-Hyslop; D Westaway; R Orlando; Margaret Mallory; Edward Rockenstein; Eliezer Masliah
Aberrant presenilin-1 expression downregulates LDL receptor-related protein (LRP): is LRP central to Alzheimer's disease pathogenesis?
Molecular and cellular neurosciences 1999;14(2):129-40.
1999: Chris De Jonghe; Marc Cruts; Ekaterina Rogaeva; C Tysoe; Andrew Singleton; hugo vanderstichele; W Meschino; Bart Dermaut; I Vanderhoeven; Hubert Backhovens; Eugeen Vanmechelen; Christopher M Morris; John Hardy; David C Rubinsztein; Peter St George-Hyslop; Christine Van Broeckhoven
Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion.
Human molecular genetics 1999;8(8):1529-40.
1999: Peter St George-Hyslop; D A Westaway
Alzheimer's disease. Antibody clears senile plaques.
Nature 1999;400(6740):116-7.
1999: Alexander L Schwarzman; N Singh; Maria Tsiper; Luisa Gregori; A Dranovsky; Michael P. Vitek; C G Glabe; Peter St George-Hyslop; Dmitry Goldgaber
Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7932-7.
1999: York Pei; Terry Watnick; Ning He; Kairong Wang; Y Liang; Patrick Parfrey; Gregory G Germino; Peter St George-Hyslop
Somatic PKD2 mutations in individual kidney and liver cysts support a "two-hit" model of cystogenesis in type 2 autosomal dominant polycystic kidney disease.
Journal of the American Society of Nephrology : JASN 1999;10(7):1524-9.
1999: A J Elia; TL Parkes; K Kirby; Peter St George-Hyslop; Gabrielle L Boulianne; J P Phillips; Arthur J Hilliker
Expression of human FALS SOD in motorneurons of Drosophila.
Free radical biology & medicine 1999;26(9-10):1332-8.
1999: R H Swartz; Sandra Black; Peter St George-Hyslop
Apolipoprotein E and Alzheimer's disease: a genetic, molecular and neuroimaging review.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1999;26(2):77-88.
1999: E A Rogaeva; S Premkumar; Janet Grubber; L Serneels; William Scott; T Kawarai; Y Song; D L Hill; S M Abou-Donia; Eden R Martin; Jeffery Vance; Gang G. Yu; A Orlacchio; Y Pei; M Nishimura; Agnes Supala; B Roberge; Ann M Saunders; Allen D Roses; Donald E Schmechel; A Crane-Gatherum; Sandro Sorbi; A Bruni; Gary W Small; P M Conneally; Jonathan L Haines; Fred Van Leuven; Peter St George-Hyslop; Lindsay A Farrer; Margaret Pericak-Vance
An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease.
Nature genetics 1999;22(1):19-22.
1999: M Nishimura; Gang G. Yu; Peter St George-Hyslop
Biology of presenilins as causative molecules for Alzheimer disease.
Clinical genetics 1999;55(4):219-25.
1999: Yasushi Tomidokoro; Koichi Ishiguro; Yukifusa Igeta; Etsuro Matsubara; Mitsuyasu Kanai; M Shizuka; Takeshi Kawarabayashi; Yasuo Harigaya; S Kawakatsu; K Ii; Masaki Ikeda; Peter St George-Hyslop; Shunsaku Hirai; Koichi Okamoto; Mikio Shoji
Carboxyl-terminal fragments of presenilin-1 are closely related to cytoskeletal abnormalities in Alzheimer's brains.
Biochemical and biophysical research communications 1999;256(3):512-8.
1999: Georges Levesque; Gang G. Yu; M Nishimura; DM Zhang; L Levesque; Haung Yu; D Xu; Yan Liang; Ekaterina Rogaeva; Masaki Ikeda; Monika Duthie; Nicholas J Murgolo; Linda Wang; P VanderVere; Marvin Bayne; Catherine D Strader; Johanna M Rommens; Paul E Fraser; Peter St George-Hyslop
Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin.
Journal of neurochemistry 1999;72(3):999-1008.
1999: Dylan G Harwood; Warren W Barker; David A Loewenstein; Raymond Ownby; Peter St George-Hyslop; Michael Mullan; Ranjan Duara
A cross-ethnic analysis of risk factors for AD in white Hispanics and white non-Hispanics.
Neurology 1999;52(3):551-6.
1999: M Nishimura; Gang G. Yu; Georges Levesque; DM Zhang; L Ruel; Fusheng Chen; P Milman; E Holmes; Yan Liang; Toshitaka Kawarai; E Jo; Agnes Supala; Ekaterina Rogaeva; D M Xu; Christopher Janus; L Levesque; Q Bi; Monika Duthie; Richard Rozmahel; K Mattila; Lars Lannfelt; David Westaway; Howard T J Mount; James R Woodgett; Peter St George-Hyslop
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex.
Nature medicine 1999;5(2):164-9.
1999: Peter St George-Hyslop
Molecular genetics of Alzheimer disease.
Seminars in neurology 1999;19(4):371-83.
1999: Dylan G Harwood; Warren W Barker; Raymond Ownby; Peter St George-Hyslop; Ranjan Duara
Apolipoprotein-E (APO-E) genotype and symptoms of psychosis in Alzheimer's disease.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 1999;7(2):119-23.
1998: Kari M Mattila; Charlotte Forsell; Tuula Pirttilä; J O Rinne; T Lehtimäki; Matias Röyttä; Lena Lilius; A Eerola; Peter St George-Hyslop; H Frey; Lars Lannfelt
The Glu318Gly mutation of the presenilin-1 gene does not necessarily cause Alzheimer's disease.
Annals of neurology 1998;44(6):965-7.
1998: W Barker; Dylan G Harwood; Ranjan Duara; Michael Mullan; D Fallin; Peter St George-Hyslop; Ekaterina Rogaeva; Y Song
The APOE-epsilon4 allele and Alzheimer disease among African Americans, Hispanics, and whites.
JAMA : the journal of the American Medical Association 1998;280(19):1661-2; author reply 1663.
1998: Lindsay A Farrer; Carmela Abraham; Jonathan L Haines; Ekaterina Rogaeva; Y Song; WT McGraw; N Brindle; S Premkumar; William Scott; LH Yamaoka; Ann M Saunders; Allen D Roses; SA Auerbach; Sandro Sorbi; Ranjan Duara; Margaret Pericak-Vance; Peter St George-Hyslop
Association between bleomycin hydrolase and Alzheimer's disease in caucasians.
Annals of neurology 1998;44(5):808-11.
1998: Carol F Lippa; H Fujiwara; D M A Mann; Benoit I Giasson; M Baba; ML Schmidt; Linda E Nee; B O'Connell; Daniel A Pollen; Peter St George-Hyslop; Bernardino Ghetti; David Nochlin; Thomas D Bird; Nigel J Cairns; Virginia M-Y Lee; Takeshi Iwatsubo; John Q Trojanowski
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.
The American journal of pathology 1998;153(5):1365-70.
1998: Carol F Lippa; Linda E Nee; Hiroshi Mori; Peter St George-Hyslop
Abeta-42 deposition precedes other changes in PS-1 Alzheimer's disease.
Lancet 1998;352(9134):1117-8.
1998: York Pei; Ning He; Kairong Wang; M Kasenda; Andrew D Paterson; G Chan; Y Liang; J Roscoe; J Brissenden; D Hefferton; Patrick Parfrey; S Somlo; Peter St George-Hyslop
A spectrum of mutations in the polycystic kidney disease-2 (PKD2) gene from eight Canadian kindreds.
Journal of the American Society of Nephrology : JASN 1998;9(10):1853-60.
1998: Masanori Ichise; James R Ballinger; F Tanaka; M Moscovitch; Peter St George-Hyslop; D Raphael; M Freedman
Age-related changes in D2 receptor binding with iodine-123-iodobenzofuran SPECT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(9):1511-8.
1998: Ekaterina Rogaeva; S Premkumar; Y Song; Sandro Sorbi; N Brindle; A Paterson; Ranjan Duara; Georges Levesque; Gang G. Yu; M Nishimura; Masaki Ikeda; Colleen O'Toole; Toshitaka Kawarai; R Jorge; D Vilarino; Amalia C Bruni; Lindsay A Farrer; Peter St George-Hyslop
Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.
JAMA : the journal of the American Medical Association 1998;280(7):614-8.
1998: Martin Citron; Christopher B Eckman; Thekla S Diehl; C Corcoran; Beth L Ostaszewski; Weiming Xia; Georges Levesque; Peter St George-Hyslop; Steven G Younkin; Dennis J Selkoe
Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Neurobiology of disease 1998;5(2):107-16.
1998: You-Qiang Song; Ekaterina Rogaeva; S Premkumar; N Brindle; Toshitaka Kawarai; A Orlacchio; Gang G. Yu; Georges Levesque; M Nishimura; Masaki Ikeda; Y Pei; Colleen O'Toole; Ranjan Duara; W Barker; Sandro Sorbi; M Freedman; Lindsay A Farrer; Peter St George-Hyslop
Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE.
Neuroscience letters 1998;250(3):189-92.
1998: Gang G. Yu; Fusheng Chen; Georges Levesque; M Nishimura; DM Zhang; L Levesque; Ekaterina Rogaeva; D Xu; Yan Liang; Monika Duthie; Peter St George-Hyslop; Paul E Fraser
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin.
The Journal of biological chemistry 1998;273(26):16470-5.
1998: Akira Tamaoka; Paul E Fraser; Kazuhiro Ishii; N Sahara; K Ozawa; Masaki Ikeda; Ann M Saunders; Yasuko Komatsuzaki; R Sherrington; Georges Levesque; Gang G. Yu; Ekaterina Rogaeva; Shin'ichi Shoji; Linda E Nee; Daniel A Pollen; L Hendriks; J J Martin; Christine Van Broeckhoven; Allen D Roses; Lindsay A Farrer; Peter St George-Hyslop; Hiroshi Mori
Amyloid-beta-protein isoforms in brain of subjects with PS1-linked, beta APP-linked and sporadic Alzheimer disease.
Brain research. Molecular brain research 1998;56(1-2):178-85.
1998: York Pei; Kairong Wang; M Kasenda; Andrew D Paterson; Y Liang; E Huang; J Lian; E Rogovea; S Somlo; Peter St George-Hyslop
A novel frameshift mutation induced by an adenosine insertion in the polycystic kidney disease 2 (PKD2) gene.
Kidney international 1998;53(5):1127-32.
1998: N Brindle; Y Song; Ekaterina Rogaeva; S Premkumar; Georges Levesque; Gang G. Yu; Masaki Ikeda; M Nishimura; A Paterson; Sandro Sorbi; Ranjan Duara; Lindsay A Farrer; Peter St George-Hyslop
Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.
Human molecular genetics 1998;7(5):933-5.
1998: Yorihide Hayashi; R Fukatsu; K Tsuzuki; Taku Yoshida; Nobuyuki Sasaki; K Kimura; Haruyasu Yamaguchi; Peter St George-Hyslop; Nobuhiro Fujii; N Takahata
Evidence for presenilin-1 involvement in amyloid angiopathy in the Alzheimer's disease-affected brain.
Brain research 1998;789(2):307-14.
1998: Yoshiaki Furukawa; Anthony E Lang; JM Trugman; Thomas D Bird; A Hunter; M Sadeh; T Tagawa; Peter St George-Hyslop; Mark Guttman; L W Morris; Oleh Hornykiewicz; M Shimadzu; Stephen J Kish
Gender-related penetrance and de novo GTP-cyclohydrolase I gene mutations in dopa-responsive dystonia.
Neurology 1998;50(4):1015-20.
1998: Haike Reznik-Wolf; Therese A Treves; Herzel Shabtai; J Aharon-Peretz; J Chapman; M Davidson; Gad Barkai; Peter St George-Hyslop; Boleslaw Goldman; Amos D Korczyn; Eitan Friedman
Germline mutational analysis of presenilin 1 and APP genes in Jewish-Israeli individuals with familial or early-onset Alzheimer disease using denaturing gradient gel electrophoresis (DGGE).
European journal of human genetics : EJHG 1998;6(2):176-80.
1998: Peter St George-Hyslop
Role of genetics in tests of genotype, status, and disease progression in early-onset Alzheimer's disease.
Neurobiology of aging 1998;19(2):133-7.
1998: M G Ramirez-Dueñas; E A Rogaeva; C A Leal; C Lin; G A Ramirez-Casillas; J A Hernandez-Romo; Peter St George-Hyslop; J M Cantu
A novel Leu171Pro mutation in presenilin-1 gene in a Mexican family with early onset Alzheimer disease.
Annales de génétique 1998;41(3):149-53.
1998: Paul E Fraser; Georges Levesque; Gang G. Yu; Linda R Mills; J Thirlwell; Marina V Frantseva; Sam Gandy; M Seeger; Peter Louis Carlen; Peter St George-Hyslop
Presenilin 1 is actively degraded by the 26S proteasome.
Neurobiology of aging 1998;19(1 Suppl):S19-21.
1998: S Sato; K Kamino; Tsuneharu Miki; A Doi; K Ii; Peter St George-Hyslop; Toshio Ogihara; Y Sakaki
Splicing mutation of presenilin-1 gene for early-onset familial Alzheimer's disease.
Human mutation 1998;Suppl 1():S91-4.
1998: Marc Cruts; C.M. Duijn; Hubert Backhovens; Marleen Van den Broeck; A Wehnert; Sally Serneels; R Sherrington; Michael Hutton; John Hardy; Peter St George-Hyslop; Albert Hofman; Christine Van Broeckhoven
Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease.
Human molecular genetics 1998;7(1):43-51.
1997: M Okochi; Kazuhiro Ishii; Mihoko Usami; N Sahara; Fuyuki Kametani; K Tanaka; Paul E Fraser; Masaki Ikeda; Ann M Saunders; L Hendriks; Shin'ichi Shoji; Linda E Nee; J J Martin; Christine Van Broeckhoven; Peter St George-Hyslop; Allen D Roses; Hiroshi Mori
Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations.
FEBS letters 1997;418(1-2):162-6.
1997: Charlotte Forsell; S Froelich; Karin Axelman; M Vestling; Richard Frank Cowburn; Lena Lilius; J A Johnston; Benita Engvall; Kurt Johansson; A Dahlkild; M Ingelson; Peter St George-Hyslop; Lars Lannfelt
A novel pathogenic mutation (Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease.
Neuroscience letters 1997;234(1):3-6.
1997: Jochen Walter; J Grünberg; Anja Capell; B Pesold; A Schindzielorz; Martin Citron; Klaus Mendla; Peter St George-Hyslop; Gerd Multhaup; Dennis J Selkoe; Christian Haass
Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5349-54.
1997: John B J Kwok; Kevin Taddei; Marianne Hallupp; C Fisher; William S Brooks; G Anthony Broe; John Hardy; M J Fulham; G A Nicholson; R Stell; Peter St George-Hyslop; Paul E Fraser; Byron A Kakulas; Roger Clarnette; Norman Richard Relkin; Sam Gandy; Peter R Schofield; Ralph N Martins
Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype.
Neuroreport 1997;8(6):1537-42.
1997: Masashi Aoki; K Abe; N Oda; Masaki Ikeda; T Tsuda; M Kanai; Mikio Shoji; Peter St George-Hyslop; Yasuto Itoyama
A presenilin-1 mutation in a Japanese family with Alzheimer's disease and distinctive abnormalities on cranial MRI.
Neurology 1997;48(4):1118-20.
1997: Evgeny I Rogaev; R Sherrington; C Wu; Georges Levesque; Yan Liang; Ekaterina Rogaeva; Masaki Ikeda; K Holman; C Lin; Walter J Lukiw; P J de Jong; Paul E Fraser; Johanna M Rommens; Peter St George-Hyslop
Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease.
Genomics 1997;40(3):415-24.
1997: Stephen G Post; Peter J Whitehouse; Robert H Binstock; Thomas D Bird; S K Eckert; Lindsay A Farrer; L M Fleck; Atwood D Gaines; Eric T Juengst; H Karlinsky; S Miles; Thomas H Murray; Kimberly Quaid; Norman Richard Relkin; Allen D Roses; Peter St George-Hyslop; Greg A. Sachs; B Steinbock; E F Truschke; A B Zinn
The clinical introduction of genetic testing for Alzheimer disease. An ethical perspective.
JAMA : the journal of the American Medical Association 1997;277(10):832-6.
1997: Gabrielle L Boulianne; I Livne-Bar; J M Humphreys; Yan Liang; C Lin; Evgeny I Rogaev; Peter St George-Hyslop
Cloning and characterization of the Drosophila presenilin homologue.
Neuroreport 1997;8(4):1025-9.
1997: Kazuhiro Ishii; Akira Tamaoka; H Mizusawa; Shin'ichi Shoji; T Ohtake; Paul E Fraser; H Takahashi; S Tsuji; Marla Gearing; T Mizutani; S Yamada; M Kato; Peter St George-Hyslop; Suzanne S Mirra; Hiroshi Mori
Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease.
Brain research 1997;748(1-2):250-2.
1997: M Cantillon; Dylan G Harwood; W Barker; Peter St George-Hyslop; T Tsuda; R Ekatarina; Ranjan Duara
No association between apolipoprotein E genotype and late-onset depression in Alzheimer's disease.
Biological psychiatry 1997;41(2):246-8.
1997: Marcia B Podlisny; Martin Citron; P Amarante; R Sherrington; Weiming Xia; Jimin Zhang; Thekla S Diehl; Georges Levesque; Paul E Fraser; Christian Haass; Edward H Koo; Peter Seubert; Peter St George-Hyslop; David B Teplow; Dennis J Selkoe
Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Neurobiology of disease 1997;3(4):325-37.
1997: Roberto Lopez; Warren W Barker; Dylan G Harwood; David A Loewenstein; Peter St George-Hyslop; T Tsuda; Ekaterina Rogaeva; Ranjan Duara
Interfamilial and intrafamilial phenotypic heterogeneity in familial Alzheimer's disease.
Journal of geriatric psychiatry and neurology 1997;10(1):1-6.
1997: Martin Citron; David Westaway; Weiming Xia; G Carlson; Thekla S Diehl; Georges Levesque; Kelly Johnson-Wood; Mike Lee; Peter Seubert; A Davis; Dora Kholodenko; Ruth Motter; R Sherrington; B Perry; H Yao; R Strome; I Lieberburg; Johanna M Rommens; S Kim; Dale Schenk; Paul E Fraser; Peter St George-Hyslop; Dennis J Selkoe
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Nature medicine 1997;3(1):67-72.
1996: Masaki Ikeda; V Sharma; Shuzo M Sumi; Ekaterina Rogaeva; Parvoneh Poorkaj-Navas; R Sherrington; Linda E Nee; T Tsuda; N Oda; M Watanabe; M Aoki; Mikio Shoji; K Abe; Y Itoyama; S Hirai; Gerard D Schellenberg; Thomas D Bird; Peter St George-Hyslop
The clinical phenotype of two missense mutations in the presenilin I gene in Japanese patients.
Annals of neurology 1996;40(6):912-7.
1996: H Reznik-Wolf; T A Treves; M Davidson; J Aharon-Peretz; Peter St George-Hyslop; J Chapman; Amos D Korczyn; B Goldman; Eitan Friedman
A novel mutation of presenilin 1 in familial Alzheimer's disease in Israel detected by denaturing gradient gel electrophoresis.
Human genetics 1996;98(6):700-2.
1996: Jochen Walter; Anja Capell; J Grünberg; B Pesold; A Schindzielorz; R Prior; Marcia B Podlisny; Paul E Fraser; Peter St George-Hyslop; Dennis J Selkoe; Christian Haass
The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.
Molecular medicine (Cambridge, Mass.) 1996;2(6):673-91.
1996: Toshiki Uchihara; H K el Hachimi; Charles Duyckaerts; J F Foncin; Paul E Fraser; L Levesque; Peter St George-Hyslop; JEAN-JACQUES HAUW
Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: double-labeling immunohistochemical study.
Acta neuropathologica 1996;92(4):325-30.
1996: R Sherrington; S Froelich; Sandro Sorbi; Dominique Campion; H Chi; Ekaterina Rogaeva; Georges Levesque; Evgeny I Rogaev; C Lin; Yan Liang; Masaki Ikeda; L Mar; Alexis Brice; Yves Agid; M E Percy; F Clerget-Darpoux; Silvia Piacentini; Giordana Marcon; Benedetta Nacmias; Luigi Amaducci; Thierry Frebourg; Lars Lannfelt; Johanna M Rommens; Peter St George-Hyslop
Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.
Human molecular genetics 1996;5(7):985-8.
1996: Shuichi Igarashi; Yoshihisa Takiyama; G Cancel; Ekaterina Rogaeva; H Sasaki; A Wakisaka; Y X Zhou; H Takano; K Endo; K Sanpei; Mutsuo Oyake; Hajime Tanaka; Giovanni Stevanin; Nacer Abbas; Alexandra Dürr; Evgeny I Rogaev; R Sherrington; T Tsuda; Masaki Ikeda; E Cassa; Masatoyo Nishizawa; Ali Benomar; J Julien; Jean Weissenbach; G X Wang; Yves Agid; Peter St George-Hyslop; Alexis Brice; S Tsuji
Intergenerational instability of the CAG repeat of the gene for Machado-Joseph disease (MJD1) is affected by the genotype of the normal chromosome: implications for the molecular mechanisms of the instability of the CAG repeat.
Human molecular genetics 1996;5(7):923-32.
1996: Evgeny I Rogaev; Ekaterina Rogaeva; GI Korovaitseva; Lindsay A Farrer; A N Petrin; S A Keryanov; S Turaeva; I Chumakov; Peter St George-Hyslop; Evgeny K Ginter
Linkage of polymorphic congenital cataract to the gamma-crystallin gene locus on human chromosome 2q33-35.
Human molecular genetics 1996;5(5):699-703.
1996: Kouzin Kamino; S Sato; Y Sakaki; A Yoshiiwa; Y Nishiwaki; Masatoshi Takeda; H Tanabe; Tsunehiko Nishimura; K Ii; Peter St George-Hyslop; T Miki; Toshio Ogihara
Three different mutations of presenilin 1 gene in early-onset Alzheimer's disease families.
Neuroscience letters 1996;208(3):195-8.
1996: Mary C Tierney; John P Szalai; W Gary Snow; R H Fisher; A Nores; G Nadon; E Dunn; Peter St George-Hyslop
Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study.
Neurology 1996;46(3):661-5.
1996: M K Trower; S M Orton; I J Purvis; P Sanseau; J Riley; C Christodoulou; D Burt; Chee Gee See; greg elgar; R Sherrington; Evgeny I Rogaev; Peter St George-Hyslop; Sydney Brenner; C W Dykes
Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus)
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1366-9.
1996: Mary C Tierney; John P Szalai; W Gary Snow; R H Fisher; T Tsuda; H Chi; D R McLachlan; Peter St George-Hyslop
A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment.
Neurology 1996;46(1):149-54.
1995: Masaki Ikeda; K Abe; M Aoki; M Sahara; M Watanabe; Mikio Shoji; Peter St George-Hyslop; Shunsaku Hirai; Y Itoyama
Variable clinical symptoms in familial amyotrophic lateral sclerosis with a novel point mutation in the Cu/Zn superoxide dismutase gene.
Neurology 1995;45(11):2038-42.
1995: Paul Tuite; Ekaterina Rogaeva; Peter St George-Hyslop; Anthony E Lang
Dopa-responsive parkinsonism phenotype of Machado-Joseph disease: confirmation of 14q CAG expansion.
Annals of neurology 1995;38(4):684-7.
1995: Sandro Sorbi; Benedetta Nacmias; Paolo Forleo; Silvia Piacentini; R Sherrington; Evgeny I Rogaev; Peter St George-Hyslop; Luigi Amaducci
Missense mutation of S182 gene in Italian families with early-onset Alzheimer's disease.
Lancet 1995;346(8972):439-40.
1995: R Sherrington; Evgeny I Rogaev; Yan Liang; Ekaterina Rogaeva; Georges Levesque; Masaki Ikeda; H Chi; C Lin; G Li; K Holman; T Tsuda; L Mar; J F Foncin; A C Bruni; M P Montesi; Sandro Sorbi; I Rainero; L Pinessi; L Nee; I Chumakov; D Pollen; A Brookes; P Sanseau; R J Polinsky; W Wasco; H A Da Silva; J L Haines; M A Perkicak-Vance; Rudolph E Tanzi; Allen D Roses; Paul E Fraser; J M Rommens; Peter St George-Hyslop
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.
Nature 1995;375(6534):754-60.
1995: K Young; C K Jones; Pedro Piccardo; Alice Lazzarini; Lawrence I Golbe; T R Zimmerman; dennis dickson; D C McLachlan; Peter St George-Hyslop; A Lennox
Gerstmann-Sträussler-Scheinker disease with mutation at codon 102 and methionine at codon 129 of PRNP in previously unreported patients.
Neurology 1995;45(6):1127-34.
1995: X Chen; H A de Silva; M J Pettenati; P N Rao; Peter St George-Hyslop; Allen D Roses; Y Xia; K Horsburgh; K Uéda; T Saitoh
The human NACP/alpha-synuclein gene: chromosome assignment to 4q21.3-q22 and TaqI RFLP analysis.
Genomics 1995;26(2):425-7.
1995: Henry Querfurth; E M Wijsman; Peter St George-Hyslop; Dennis J Selkoe
Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family.
Brain research. Molecular brain research 1995;28(2):319-37.
1995: Peter St George-Hyslop
Genetic determinants of Alzheimer disease.
Progress in clinical and biological research 1995;393():139-45.
1995: D W Cox; T Gedde-Dahl; A G Menon; T G Nygaard; I M Tomlinson; J Peters; Peter St George-Hyslop; M A Walter; J H Edwards
Report of the second international workshop on human chromosome 14 mapping 1994.
Cytogenetics and cell genetics 1995;69(3-4):159-74.
1994: Anthony E Lang; Ekaterina Rogaeva; T Tsuda; J Hutterer; Peter St George-Hyslop
Homozygous inheritance of the Machado-Joseph disease gene.
Annals of neurology 1994;36(3):443-7.
1994: M Mortilla; Giovanna Vaula; Peter St George-Hyslop
Assessment of genetic polymorphisms in DNA from formalin fixed neurological tissues.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1994;21(3):248-51.
1994: Evgeny I Rogaev; Walter J Lukiw; O Lavrushina; Ekaterina Rogaeva; Peter St George-Hyslop
The upstream promoter of the beta-amyloid precursor protein gene (APP) shows differential patterns of methylation in human brain.
Genomics 1994;22(2):340-7.
1994: Peter St George-Hyslop; Ekaterina Rogaeva; J Huterer; T Tsuda; J Santos; Jonathan L Haines; K Schlumpf; Evgeny I Rogaev; Yan Liang; D R McLachlan
Machado-Joseph disease in pedigrees of Azorean descent is linked to chromosome 14.
American journal of human genetics 1994;55(1):120-5.
1994: Walter J Lukiw; Evgeny I Rogaev; L Wong; Giovanna Vaula; D R McLachlan; Peter St George-Hyslop
Protein-DNA interactions in the promoter region of the amyloid precursor protein (APP) gene in human neocortex.
Brain research. Molecular brain research 1994;22(1-4):121-31.
1994: Evgeny I Rogaev; Ekaterina Rogaeva; Evgeny K Ginter; G I Korovaĭtseva; Lindsay A Farrer; A B Shlenskiĭ; A N Prytkov; Peter St George-Hyslop; V N Mordovtsev
[Mapping the gene for palmoplantar hyperkeratosis (thylosis) to chromosome 17 in the 17q12-q24 region].
Genetika 1994;30(3):326-9.
1994: Peter St George-Hyslop; D C McLachlan; T Tsuda; Evgeny I Rogaev; H Karlinsky; Carol F Lippa; Daniel A Pollen; T Tuda
Alzheimer's disease and possible gene interaction.
Science (New York, N.Y.) 1994;263(5146):537.
1994: Anne M Bowcock; J Tomfohrde; J Weissenbach; B Bonne-Tamir; Peter St George-Hyslop; Marcello Giagheddu; L L Cavalli-Sforza; Lindsay A Farrer
Refining the position of Wilson disease by linkage disequilibrium with polymorphic microsatellites.
American journal of human genetics 1994;54(1):79-87.
1993: Evgeny I Rogaev; Walter J Lukiw; Giovanna Vaula; Jonathan L Haines; Ekaterina Rogaeva; T Tsuda; N Alexandrova; Yan Liang; M Mortilla; Luigi Amaducci; L Bergamini; A C Bruni; J F Foncin; F Macciardi; M Montesi; Sandro Sorbi; I Rainero; L Pinessi; R J Polinsky; Peter Frommelt; Ranjan Duara; Roberto Lopez; D Pollen; James Gusella; Rudolph E Tanzi; D MacLachlan; D Crapper; Peter St George-Hyslop
Analysis of the c-FOS gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease.
Neurology 1993;43(11):2275-9.
1993: E A Stewart; A White; J Tomfohrde; S Osborne-Lawrence; L Prestridge; B Bonne-Tamir; I H Scheinberg; Peter St George-Hyslop; Marcello Giagheddu; J W Kim
Polymorphic microsatellites and Wilson disease (WD).
American journal of human genetics 1993;53(4):864-73.
1993: Evgeny I Rogaev; Ekaterina Rogaeva; Evgeny K Ginter; GI Korovaitseva; Lindsay A Farrer; A B Shlensky; A N Pritkov; V N Mordovtsev; Peter St George-Hyslop
Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes.
Nature genetics 1993;5(2):158-62.
1993: Ann M Saunders; Warren J Strittmatter; Donald E Schmechel; Peter St George-Hyslop; Margaret Pericak-Vance; S H Joo; B L Rosi; James Gusella; D R Crapper-MacLachlan; Mark J Alberts
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.
Neurology 1993;43(8):1467-72.
1993: R Tupler; Ekaterina Rogaeva; Giovanna Vaula; M Mortilla; Walter J Lukiw; Yan Liang; R Hancock; Evgeny I Rogaev; Peter St George-Hyslop
A highly informative microsatellite repeat polymorphism in intron 1 of the human amyloid precursor protein (APP) gene.
Human molecular genetics 1993;2(5):620.
1993: Margaret Pericak-Vance; Peter St George-Hyslop; Perry C Gaskell; John H Growdon; Barbara J Crain; Christine M Hulette; James Gusella; LH Yamaoka; Rudolph E Tanzi; Allen D Roses
Linkage analysis in familial Alzheimer disease: description of the Duke and Boston data sets.
Genetic epidemiology 1993;10(6):361-4.
1992: Peter St George-Hyslop; Jonathan L Haines; Evgeny I Rogaev; M Mortilla; Giovanna Vaula; Margaret Pericak-Vance; J F Foncin; M Montesi; A Bruni; Sandro Sorbi; I Rainero; L Pinessi; D Pollen; R Polinsky; L Nee; J Kennedy; F Macciardi; E Rogaeva; Y Liang; N Alexandrova; W Lukiw; K Schlumpf; Rudolph E Tanzi; T Tsuda; L Farrer; J M Cantu; Ranjan Duara; L Amaducci; L Bergamini; James Gusella; Allen D Roses; D Crapper McLachlan
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.
Nature genetics 1992;2(4):330-4.
1992: Evgeny I Rogaev; Ekaterina Rogaeva; Walter J Lukiw; Giovanna Vaula; Yan Liang; R Hancock; D C McLachlan; Peter St George-Hyslop
An informative microsatellite repeat polymorphism in the human neurofilament light polypeptide (NEFL) gene.
Human molecular genetics 1992;1(9):781.
1992: H Karlinsky; J M Berg; A Lennox; P N Ray; Peter St George-Hyslop; Lindsay A Farrer; Maire E Percy; D F Andrews; E A Atack
Monozygotic twins concordant for late-onset probable Alzheimer disease with suspected Alzheimer disease in four sibs.
American journal of medical genetics 1992;44(5):591-7.
1992: Scott T Grafton; John C Mazziotta; J J Pahl; Peter St George-Hyslop; Jonathan L Haines; James Gusella; J M Hoffman; Lewis R Baxter; Michael E Phelps
Serial changes of cerebral glucose metabolism and caudate size in persons at risk for Huntington's disease.
Archives of neurology 1992;49(11):1161-7.
1992: Peter St George-Hyslop; H Ohno; James Gusella; Timothy W McKeithan
The BCL3 locus on chromosome 19 displays an informative microsatellite polymorphism.
Nucleic acids research 1992;20(4):927.
1992: Lewis R Baxter; John C Mazziotta; J J Pahl; Scott T Grafton; Peter St George-Hyslop; Jonathan L Haines; James Gusella; Martin P Szuba; C E Selin; Barry Guze
Psychiatric, genetic, and positron emission tomographic evaluation of persons at risk for Huntington's disease.
Archives of general psychiatry 1992;49(2):148-54.
1991: Rudolph E Tanzi; Peter St George-Hyslop; James Gusella
Molecular genetics of Alzheimer disease amyloid.
The Journal of biological chemistry 1991;266(31):20579-82.
1991: Lindsay A Farrer; Anne M Bowcock; J M Hebert; B Bonné-Tamir; I Sternlieb; Marcello Giagheddu; Peter St George-Hyslop; Moshe Frydman; J Lössner; L Demelia
Predictive testing for Wilson's disease using tightly linked and flanking DNA markers.
Neurology 1991;41(7):992-9.
1991: K Abe; Peter St George-Hyslop; Rudolph E Tanzi; K Kogure
Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells.
Neuroscience letters 1991;125(2):169-71.
1991: Anand Kumar; Mark B Schapiro; Cheryl L Grady; M F Matocha; James V Haxby; A M Moore; J S Luxenberg; Peter St George-Hyslop; C D Robinette; Melvyn Ball
Anatomic, metabolic, neuropsychological, and molecular genetic studies of three pairs of identical twins discordant for dementia of the Alzheimer's type.
Archives of neurology 1991;48(2):160-8.
1990: Scott T Grafton; John C Mazziotta; J J Pahl; Peter St George-Hyslop; Jonathan L Haines; James Gusella; J M Hoffman; Lewis R Baxter; Michael E Phelps
A comparison of neurological, metabolic, structural, and genetic evaluations in persons at risk for Huntington's disease.
Annals of neurology 1990;28(5):614-21.
1990: Peter St George-Hyslop; Jonathan L Haines; Lindsay A Farrer; R Polinsky; Christine Van Broeckhoven; Alison Goate; D R McLachlan; H Orr; A C Bruni; Sandro Sorbi; I Rainero; J F Foncin; D Pollen; J M Cantu; R Tupler; N Voskresenskaya; Richard Mayeux; J Growden; V A Fried; Richard H Myers; L Nee; H Backhovens; J J Martin; Martin N Rossor; Michael J Owen; Michael Mullan; M E Percy; H Karlinsky; S Rich; L Heston; M Montesi; M Mortilla; N Nacmias; James Gusella; John Hardy
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.
Nature 1990;347(6289):194-7.
1990: Lindsay A Farrer; Richard H Myers; L Adrienne Cupples; Peter St George-Hyslop; Thomas D Bird; Martin N Rossor; Michael Mullan; R Polinsky; Linda E Nee; L Heston
Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity.
Neurology 1990;40(3 Pt 1):395-403.
1989: Peter St George-Hyslop; Jonathan L Haines; R J Polinsky; Rudolph E Tanzi; Lindsay A Farrer; Richard H Myers; James Gusella
Molecular genetics of familial Alzheimer's disease.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1989;16(4 Suppl):465-7.
1989: Peter St George-Hyslop; Richard H Myers; Jonathan L Haines; Lindsay A Farrer; Rudolph E Tanzi; K Abe; M F James; P M Conneally; R J Polinsky; James Gusella
Familial Alzheimer's disease: progress and problems.
Neurobiology of aging 1989;10(5):417-25.
1989: Rudolph E Tanzi; Peter St George-Hyslop; James Gusella
Molecular genetic approaches to Alzheimer's disease.
Trends in neurosciences 1989;12(4):152-8.
1989: Peter St George-Hyslop; Rudolph E Tanzi; Jonathan L Haines; R J Polinsky; Lindsay A Farrer; Richard H Myers; James Gusella
Molecular genetics of familial Alzheimer's disease.
European neurology 1989;29 Suppl 3():25-7.
1988: Jonathan L Haines; Laurie J Ozelius; Peter St George-Hyslop; N S Wexler; James Gusella; P M Conneally
Partial linkage map of chromosome 13q in the region of the Wilson disease and retinoblastoma genes.
Genetic epidemiology 1988;5(6):375-80.
1987: Peter St George-Hyslop; Rudolph E Tanzi; R J Polinsky; R L Neve; Daniel A Pollen; Daniel B Drachman; John H Growdon; L A Cupples; Linda E Nee; Richard H Myers
Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease.
Science (New York, N.Y.) 1987;238(4827):664-6.
1987: Rudolph E Tanzi; Peter St George-Hyslop; Jonathan L Haines; R J Polinsky; L Nee; J F Foncin; R L Neve; Andrea I McClatchey; P M Conneally; James Gusella
The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene.
Nature 1987;329(6135):156-7.
1987: BR Seizinger; G Rouleau; Laurie J Ozelius; Andrew lane; Peter St George-Hyslop; S Huson; James Gusella; R L Martuza
Common pathogenetic mechanism for three tumor types in bilateral acoustic neurofibromatosis.
Science (New York, N.Y.) 1987;236(4799):317-9.
1987: Rudolph E Tanzi; James Gusella; P C Watkins; G A Bruns; Peter St George-Hyslop; M L Van Keuren; D Patterson; S Pagan; David M Kurnit; R L Neve
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.
Science (New York, N.Y.) 1987;235(4791):880-4.
1987: Peter St George-Hyslop; Rudolph E Tanzi; R J Polinsky; Jonathan L Haines; Linda E Nee; P C Watkins; Richard H Myers; R G Feldman; Daniel A Pollen; Daniel B Drachman
The genetic defect causing familial Alzheimer's disease maps on chromosome 21.
Science (New York, N.Y.) 1987;235(4791):885-90.
1987: Peter St George-Hyslop; R Polinsky; Jonathan L Haines; Linda E Nee; Rudolph E Tanzi; P Conneally; John H Growdon; Richard H Myers; Daniel A Pollen; Daniel B Drachman
Search for the familial Alzheimer's disease gene.
Journal of neural transmission. Supplementum 1987;24():13-21.
1984: R V Hodder; Peter St George-Hyslop; A Chalvardjian; R A Bear; P Thomas
Pulmonary malakoplakia.
Thorax 1984;39(1):70-1.
1977: W G Thompson; Peter St George-Hyslop; R Barr; A Sass-Kortsak
Wilson's disease: a common liver disorder?
Canadian Medical Association journal 1977;117(1):45-8.