Bart Staels

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Staels Bart; Fonseca Vivian A
Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration.
Røst Therese H; Haugan Moi Line L; Berge Kjetil; Staels Bart; Mellgren Gunnar; Berge Rolf K
A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation.
Lalloyer Fanny; Pedersen Thomas Askov; Gross Barbara; Lestavel Sophie; Yous Saïd; Vallez Emmanuelle; Gustafsson Jan-Ake; Mandrup Susanne; Fiévet Catherine; Staels Bart; Tailleux Anne
Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver.

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All Publications

2009: Staels Bart; Fonseca Vivian A
Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration.
Diabetes care 2009;32 Suppl 2():S237-45.
2009: Røst Therese H; Haugan Moi Line L; Berge Kjetil; Staels Bart; Mellgren Gunnar; Berge Rolf K
A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation.
Biochimica et biophysica acta 2009;1791(11):1076-83.
2009: Lalloyer Fanny; Pedersen Thomas Askov; Gross Barbara; Lestavel Sophie; Yous Saïd; Vallez Emmanuelle; Gustafsson Jan-Ake; Mandrup Susanne; Fiévet Catherine; Staels Bart; Tailleux Anne
Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(10):1488-95.
2009: Giugliano Dario; Standl Eberhard; Vilsbøll Tina; Betteridge John; Bonadonna Riccardo; Campbell Ian W; Schernthaner Gerit-Holger; Staels Bart; Trichopoulou Antonia; Farinaro Eduardo
Is the current therapeutic armamentarium in diabetes enough to control the epidemic and its consequences? What are the current shortcomings?
Acta diabetologica 2009;46(3):173-81.
2009: Bougarne Nadia; Paumelle Réjane; Haegeman Guy; Staels Bart; De Bosscher Karolien
Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPARalpha.
Cell cycle (Georgetown, Tex.) 2009;8(15):2311-2.
2009: Mysiorek Caroline; Culot Maxime; Dehouck Lucie; Derudas Bruno; Staels Bart; Bordet Régis; Cecchelli Roméo; Fenart Laurence; Berezowski Vincent
Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier.
Current neurovascular research 2009;6(3):181-93.
2009: Bouhlel Mohamed Amine; Brozek John; Derudas Bruno; Zawadzki Christophe; Jude Brigitte; Staels Bart; Chinetti-Gbaguidi Giulia
Unlike PPARgamma, PPARalpha or PPARbeta/delta activation does not promote human monocyte differentiation toward alternative macrophages.
Biochemical and biophysical research communications 2009;386(3):459-62.
2009: Provost Alexandra C; Vede Leonie; Bigot Karine; Keller Nicole; Tailleux Anne; Jaïs Jean-Philipe; Savoldelli Michelle; Ameqrane Ilhame; Lacassagne Emmanuelle; Legeais Jean-Marc; Staels Bart; Menasche Maurice; Mallat Ziad; Behar-Cohen Francine; Abitbol Marc
Morphologic and electroretinographic phenotype of SR-BI knockout mice after a long-term atherogenic diet.
Investigative ophthalmology & visual science 2009;50(8):3931-42.
2009: Ogata Masaki; Tsujita Maki; Hossain Mohammad Anwar; Akita Nobukatsu; Gonzalez Frank J; Staels Bart; Suzuki Shogo; Fukutomi Tatsuya; Kimura Genjiro; Yokoyama Shinji
On the mechanism for PPAR agonists to enhance ABCA1 gene expression.
Atherosclerosis 2009;205(2):413-9.
2009: Goebel Matthias; Staels Bart; Unger Thomas; Kintscher Ulrich; Gust Ronald
Characterization of new PPARgamma agonists: benzimidazole derivatives - the importance of position 2.
ChemMedChem 2009;4(7):1136-42.
2009: Fiévet Catherine; Staels Bart
Efficacy of peroxisome proliferator-activated receptor agonists in diabetes and coronary artery disease.
Current atherosclerosis reports 2009;11(4):281-8.
2009: Duez Hélène; Duhem Christian; Laitinen Saara; Patole Prashant S; Abdelkarim Mouaadh; Bois-Joyeux Brigitte; Danan Jean-Louis; Staels Bart
Inhibition of adipocyte differentiation by RORalpha.
FEBS letters 2009;583(12):2031-6.
2009: Chinetti-Gbaguidi G; Staels B
Lipid ligand-activated transcription factors regulating lipid storage and release in human macrophages.
Biochimica et biophysica acta 2009;1791(6):486-93.
2009: Zamblé Alexis; Martin-Nizard Françoise; Sahpaz Sevser; Reynaert Marie-Line; Staels Bart; Bordet Régis; Duriez Patrick; Gressier Bernard; Bailleul François
Effects of Microdesmis keayana alkaloids on vascular parameters of erectile dysfunction.
Phytotherapy research : PTR 2009;23(6):892-5.
2009: Zawadzki Christophe; Chatelain Nicolas; Delestre Marianne; Susen Sophie; Quesnel Bruno; Juthier Francis; Jeanpierre Emmanuelle; Azzaoui Richard; Corseaux Delphine; Breyne Joke; Torpier Gérard; Staels Bart; Van Belle Eric; Jude Brigitte
Tissue factor pathway inhibitor-2 gene methylation is associated with low expression in carotid atherosclerotic plaques.
Atherosclerosis 2009;204(2):e4-14.
2009: Staels Bart
A review of bile acid sequestrants: potential mechanism(s) for glucose-lowering effects in type 2 diabetes mellitus.
Postgraduate medicine 2009;121(3 Suppl 1):25-30.
2009: Bougarne Nadia; Paumelle Réjane; Caron Sandrine; Hennuyer Nathalie; Mansouri Roxane; Gervois Philippe; Staels Bart; Haegeman Guy; De Bosscher Karolien
PPARalpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappaB.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(18):7397-402.
2009: Parmenon Cécile; Guillard Jérôme; Caignard Daniel-Henri; Hennuyer Nathalie; Staels Bart; Audinot-Bouchez Valérie; Boutin Jean-Albert; Dacquet Catherine; Ktorza Alain; Viaud-Massuard Marie-Claude
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations.
Bioorganic & medicinal chemistry letters 2009;19(10):2683-7.
2009: Rambaud Juliette; Triqueneaux Gérard; Masse Ingrid; Staels Bart; Laudet Vincent; Benoit Gérard
Rev-erbalpha2 mRNA encodes a stable protein with a potential role in circadian clock regulation.
Molecular endocrinology (Baltimore, Md.) 2009;23(5):630-9.
2009: Jeanpierre Emmanuelle; Le Tourneau Thierry; Zawadzki Christophe; Van Belle Eric; Mouquet Frederic; Susen Sophie; Ezekowitz Michael D; Staels Bart; Jude Brigitte; Corseaux Delphine
Beneficial effects of fenofibrate on plaque thrombogenicity and plaque stability in atherosclerotic rabbits.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2009;18(3):140-7.
2009: van Dijk Theo H; Grefhorst Aldo; Oosterveer Maaike H; Bloks Vincent W; Staels Bart; Reijngoud Dirk-Jan; Kuipers Folkert
An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice.
The Journal of biological chemistry 2009;284(16):10315-23.
2009: Brunham Liam R; Singaraja Roshni R; Duong MyNgan; Timmins Jenelle M; Fievet Catherine; Bissada Nagat; Kang Martin H; Samra Amrit; Fruchart Jean-Charles; McManus Bruce; Staels Bart; Parks John S; Hayden Michael R
Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(4):548-54.
2009: Fiévet C; Staels B
Liver X receptor modulators: effects on lipid metabolism and potential use in the treatment of atherosclerosis.
Biochemical pharmacology 2009;77(8):1316-27.
2009: Porta Natacha; Vallée Louis; Lecointe Cécile; Bouchaert Emmanuel; Staels Bart; Bordet Régis; Auvin Stéphane
Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties.
Epilepsia 2009;50(4):943-8.
2009: Brinster Sophie; Lamberet Gilles; Staels Bart; Trieu-Cuot Patrick; Gruss Alexandra; Poyart Claire
Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens.
Nature 2009;458(7234):83-6.
2009: Goebel Matthias; Clemenz Markus; Staels Bart; Unger Thomas; Kintscher Ulrich; Gust Ronald
Characterization of new PPARgamma agonists: analysis of telmisartan's structural components.
ChemMedChem 2009;4(3):445-56.
2009: MacDonald Marcia L E; van Eck Miranda; Hildebrand Reeni B; Wong Brian W C; Bissada Nagat; Ruddle Piers; Kontush Anatol; Hussein Hala; Pouladi Mahmoud A; Chapman M John; Fievet Catherine; van Berkel Theo J C; Staels Bart; McManus Bruce M; Hayden Michael R
Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(3):341-7.
2009: Lefebvre Philippe; Cariou Bertrand; Lien Fleur; Kuipers Folkert; Staels Bart
Role of bile acids and bile acid receptors in metabolic regulation.
Physiological reviews 2009;89(1):147-91.
2009: Charton Julie; Deprez-Poulain Rebecca; Hennuyer Nathalie; Tailleux Anne; Staels Bart; Deprez Benoit
Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.
Bioorganic & medicinal chemistry letters 2009;19(2):489-92.
2008: Caron Sandrine; Staels Bart
Apolipoprotein CIII: a link between hypertriglyceridemia and vascular dysfunction?
Circulation research 2008;103(12):1348-50.
2008: Bultel Stephanie; Helin Lionel; Clavey Veronique; Chinetti-Gbaguidi Giulia; Rigamonti Elena; Colin Morvane; Fruchart Jean-Charles; Staels Bart; Lestavel Sophie
Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(12):2288-95.
2008: Fruchart Jean-Charles; Sacks Frank; Hermans Michel P; Assmann Gerd; Brown W Virgil; Ceska Richard; Chapman M John; Dodson Paul M; Fioretto Paola; Ginsberg Henry N; Kadowaki Takashi; Lablanche Jean-Marc; Marx Nikolaus; Plutzky Jorge; Reiner Zeljko; Rosenson Robert S; Staels Bart; Stock Jane K; Sy Rody; Wanner Christoph; Zambon Alberto; Zimmet Paul
The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia.
The American journal of cardiology 2008;102(10 Suppl):1K-34K.
2008: Fruchart Jean-Charles; Sacks Frank M; Hermans Michel P; Assmann Gerd; Brown W Virgil; Ceska Richard; Chapman M John; Dodson Paul M; Fioretto Paola; Ginsberg Henry N; Kadowaki Takashi; Lablanche Jean-Marc; Marx Nikolaus; Plutzky Jorge; Reiner Zeljko; Rosenson Robert S; Staels Bart; Stock Jane K; Sy Rody; Wanner Christoph; Zambon Alberto; Zimmet Paul;
The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2008;5(4):319-35.
2008: Gizard Florence; Nomiyama Takashi; Zhao Yue; Findeisen Hannes M; Heywood Elizabeth B; Jones Karrie L; Staels Bart; Bruemmer Dennis
The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation.
Circulation research 2008;103(10):1155-63.
2008: Gineste Romain; Sirvent Audrey; Paumelle Réjane; Helleboid Stéphane; Aquilina Alexis; Darteil Raphaël; Hum Dean W; Fruchart Jean-Charles; Staels Bart
Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.
Molecular endocrinology (Baltimore, Md.) 2008;22(11):2433-47.
2008: Colin Sophie; Bourguignon Elodie; Boullay Anne-Bénédicte; Tousaint Jean-Jacques; Huet Stéphane; Caira Françoise; Staels Bart; Lestavel Sophie; Lobaccaro Jean-Marc A; Delerive Philippe
Intestine-specific regulation of PPARalpha gene transcription by liver X receptors.
Endocrinology 2008;149(10):5128-35.
2008: Staels Bart; Maes Michel; Zambon Alberto
Fibrates and future PPARalpha agonists in the treatment of cardiovascular disease.
Nature clinical practice. Cardiovascular medicine 2008;5(9):542-53.
2008: Wouters Kristiaan; van Gorp Patrick J; Bieghs Veerle; Gijbels Marion J; Duimel Hans; Lütjohann Dieter; Kerksiek Anja; van Kruchten Roger; Maeda Nobuyo; Staels Bart; van Bilsen Marc; Shiri-Sverdlov Ronit; Hofker Marten H
Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.) 2008;48(2):474-86.
2008: Mansouri Roxane M; Baugé Eric; Gervois Philippe; Fruchart-Najib Jamila; Fiévet Catherine; Staels Bart; Fruchart Jean-Charles
Atheroprotective effect of human apolipoprotein A5 in a mouse model of mixed dyslipidemia.
Circulation research 2008;103(5):450-3.
2008: Duez Hélène; van der Veen Jelske N; Duhem Christian; Pourcet Benoît; Touvier Thierry; Fontaine Coralie; Derudas Bruno; Baugé Eric; Havinga Rick; Bloks Vincent W; Wolters Henk; van der Sluijs Fjodor H; Vennström Björn; Kuipers Folkert; Staels Bart
Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha.
Gastroenterology 2008;135(2):689-98.
2008: Fontaine Coralie; Rigamonti Elena; Pourcet Benoit; Duez Hélène; Duhem Christian; Fruchart Jean-Charles; Chinetti-Gbaguidi Giulia; Staels Bart
The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages.
Molecular endocrinology (Baltimore, Md.) 2008;22(8):1797-811.
2008: Duez Hélène; Staels Bart
The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2008;5(2):82-8.
2008: Mansouri Roxane M; Baugé Eric; Staels Bart; Gervois Philippe
Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-alpha control of the acute-phase response.
Endocrinology 2008;149(6):3215-23.
2008: Rigamonti Elena; Chinetti-Gbaguidi Giulia; Staels Bart
Regulation of macrophage functions by PPAR-alpha, PPAR-gamma, and LXRs in mice and men.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(6):1050-9.
2008: Rigamonti Elena; Fontaine Coralie; Lefebvre Bruno; Duhem Christian; Lefebvre Philippe; Marx Nikolaus; Staels Bart; Chinetti-Gbaguidi Giulia
Induction of CXCR2 receptor by peroxisome proliferator-activated receptor gamma in human macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(5):932-9.
2008: Clemenz Markus; Frost Nikolaj; Schupp Michael; Caron Sandrine; Foryst-Ludwig Anna; Böhm Christian; Hartge Martin; Gust Ronald; Staels Bart; Unger Thomas; Kintscher Ulrich
Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan.
Diabetes 2008;57(5):1405-13.
2008: Paumelle Réjane; Staels Bart
Cross-talk between statins and PPARalpha in cardiovascular diseases: clinical evidence and basic mechanisms.
Trends in cardiovascular medicine 2008;18(3):73-8.
2008: Staumont-Sallé Delphine; Abboud Georges; Brénuchon Céline; Kanda Akira; Roumier Thomas; Lavogiez Céline; Fleury Sébastien; Rémy Patrick; Papin Jean-Paul; Bertrand-Michel Justine; Tercé François; Staels Bart; Delaporte Emmanuel; Capron Monique; Dombrowicz David
Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis.
The Journal of allergy and clinical immunology 2008;121(4):962-8.e6.
2008: Smeets Pascal J H; Teunissen Birgit E J; Willemsen Peter H M; van Nieuwenhoven Frans A; Brouns Agnieszka E; Janssen Ben J A; Cleutjens Jack P M; Staels Bart; van der Vusse Ger J; van Bilsen Marc
Cardiac hypertrophy is enhanced in PPAR alpha-/- mice in response to chronic pressure overload.
Cardiovascular research 2008;78(1):79-89.
2008: Langhi Cédric; Le May Cédric; Kourimate Sanae; Caron Sandrine; Staels Bart; Krempf Michel; Costet Philippe; Cariou Bertrand
Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes.
FEBS letters 2008;582(6):949-55.
2008: Denechaud Pierre-Damien; Bossard Pascale; Lobaccaro Jean-Marc A; Millatt Lesley; Staels Bart; Girard Jean; Postic Catherine
ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver.
The Journal of clinical investigation 2008;118(3):956-64.
2008: Parmenon Cécile; Guillard Jérôme; Caignard Daniel-Henri; Hennuyer Nathalie; Staels Bart; Audinot-Bouchez Valérie; Boutin Jean-Albert; Dacquet Catherine; Ktorza Alain; Viaud-Massuard Marie-Claude
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARalpha/gamma agonists. Part I: synthesis and pharmacological evaluation.
Bioorganic & medicinal chemistry letters 2008;18(5):1617-22.
2008: Kaeding Jenny; Bouchaert Emmanuel; Bélanger Julie; Caron Patrick; Chouinard Sarah; Verreault Mélanie; Larouche Olivier; Pelletier Georges; Staels Bart; Bélanger Alain; Barbier Olivier
Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells.
The Biochemical journal 2008;410(2):245-53.
2008: Zamblé Alexis; Martin-Nizard Françoise; Sahpaz Sevser; Hennebelle Thierry; Staels Bart; Bordet Régis; Duriez Patrick; Brunet Claude; Bailleul François
Vasoactivity, antioxidant and aphrodisiac properties of Caesalpinia benthamiana roots.
Journal of ethnopharmacology 2008;116(1):112-9.
2008: Fan Yanbo; Wang Ying; Tang Zhihui; Zhang Hong; Qin Xiaomei; Zhu Yi; Guan Youfei; Wang Xian; Staels Bart; Chien Shu; Wang Nanping
Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(2):315-21.
2008: Carpentier Rodolphe; Sacchetti Paola; Ségard Pascaline; Staels Bart; Lefebvre Philippe
The glucocorticoid receptor is a co-regulator of the orphan nuclear receptor Nurr1.
Journal of neurochemistry 2008;104(3):777-89.
2008: Bouhlel M A; Staels B; Chinetti-Gbaguidi G
Peroxisome proliferator-activated receptors--from active regulators of macrophage biology to pharmacological targets in the treatment of cardiovascular disease.
Journal of internal medicine 2008;263(1):28-42.
2008: MacDonald Marcia L E; Singaraja Roshni R; Bissada Nagat; Ruddle Piers; Watts Russell; Karasinska Joanna M; Gibson William T; Fievet Catherine; Vance Jean E; Staels Bart; Hayden Michael R
Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice.
Journal of lipid research 2008;49(1):217-29.
2008: Duez Hélène; Staels Bart
Rev-erb alpha gives a time cue to metabolism.
FEBS letters 2008;582(1):19-25.
2008: Finck Brian N; Chinetti Giulia; Staels Bart
PPARs/RXRs in Cardiovascular Physiology and Disease.
PPAR research 2008;2008():173780.
2007: Gross Barbara; Staels Bart
PPAR agonists: multimodal drugs for the treatment of type-2 diabetes.
Best practice & research. Clinical endocrinology & metabolism 2007;21(4):687-710.
2007: Zawadzki Christophe; Susen Sophie; Richard Florence; Haulon Stéphan; Corseaux Delphine; Jeanpierre Emmanuelle; Vincentelli André; Lucas Christian; Torpier Gérard; Martin Annie; Van Belle Eric; Staels Bart; Jude Brigitte
Dyslipidemia shifts the tissue factor/tissue factor pathway inhibitor balance toward increased thrombogenicity in atherosclerotic plaques: evidence for a corrective effect of statins.
Atherosclerosis 2007;195(2):e117-25.
2007: Chinetti-Gbaguidi Giulia; Staels Bart
Measuring biomarkers to assess the therapeutic effects of PPAR agonists?
Pharmacogenomics 2007;8(11):1567-80.
2007: Bouhlel Mohamed Amine; Chinetti-Gbaguidi Giulia; Staels Bart
Glitazones in the treatment of cardiovascular risk factors.
Fundamental & clinical pharmacology 2007;21 Suppl 2():7-13.
2007: Cariou Bertrand; Bouchaert Emmanuel; Abdelkarim Mouaadh; Dumont Julie; Caron Sandrine; Fruchart Jean-Charles; Burcelin Rémy; Kuipers Folkert; Staels Bart
FXR-deficiency confers increased susceptibility to torpor.
FEBS letters 2007;581(27):5191-8.
2007: Carmona Maria Carmen; Louche Katie; Lefebvre Bruno; Pilon Antoine; Hennuyer Nathalie; Audinot-Bouchez Véronique; Fievet Catherine; Torpier Gérard; Formstecher Pierre; Renard Pierre; Lefebvre Philippe; Dacquet Catherine; Staels Bart; Casteilla Louis; Pénicaud Luc;
S 26948: a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects.
Diabetes 2007;56(11):2797-808.
2007: Murakami Takeshi; Walczak Robert; Caron Sandrine; Duhem Christian; Vidal Vincent; Darteil Raphaël; Staels Bart
The farnesoid X receptor induces fetuin-B gene expression in human hepatocytes.
The Biochemical journal 2007;407(3):461-9.
2007: Falcetti Emilia; Flavell David M; Staels Bart; Tinker Andrew; Haworth Sheila G; Clapp Lucie H
IP receptor-dependent activation of PPARgamma by stable prostacyclin analogues.
Biochemical and biophysical research communications 2007;360(4):821-7.
2007: Bouhlel M Amine; Derudas Bruno; Rigamonti Elena; Dièvart Rébecca; Brozek John; Haulon Stéphan; Zawadzki Christophe; Jude Brigitte; Torpier Gérard; Marx Nikolaus; Staels Bart; Chinetti-Gbaguidi Giulia
PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties.
Cell metabolism 2007;6(2):137-43.
2007: Yamazaki Yukiyoshi; Abe Kazutoyo; Toma Tsutomu; Nishikawa Masahiro; Ozawa Hidefumi; Okuda Ayumu; Araki Takaaki; Oda Soichi; Inoue Keisuke; Shibuya Kimiyuki; Staels Bart; Fruchart Jean-Charles
Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor alpha agonists.
Bioorganic & medicinal chemistry letters 2007;17(16):4689-93.
2007: Rubenstrunk Anne; Hanf Rémy; Hum Dean W; Fruchart Jean-Charles; Staels Bart
Safety issues and prospects for future generations of PPAR modulators.
Biochimica et biophysica acta 2007;1771(8):1065-81.
2007: Staels Bart
PPAR agonists and the metabolic syndrome.
Thérapie 2007;62(4):319-26.
2007: Raichur Suryaprakash; Lau Patrick; Staels Bart; Muscat George E O
Retinoid-related orphan receptor gamma regulates several genes that control metabolism in skeletal muscle cells: links to modulation of reactive oxygen species production.
Journal of molecular endocrinology 2007;39(1):29-44.
2007: Fontaine Coralie; Rigamonti Elena; Nohara Atsushi; Gervois Philippe; Teissier Elisabeth; Fruchart Jean-Charles; Staels Bart; Chinetti-Gbaguidi Giulia
Liver X receptor activation potentiates the lipopolysaccharide response in human macrophages.
Circulation research 2007;101(1):40-9.
2007: Brigadeau François; Gelé Patrick; Wibaux Maud; Marquié Christelle; Martin-Nizard Françoise; Torpier Gérard; Fruchart Jean-Charles; Staels Bart; Duriez Patrick; Lacroix Dominique
The PPARalpha activator fenofibrate slows down the progression of the left ventricular dysfunction in porcine tachycardia-induced cardiomyopathy.
Journal of cardiovascular pharmacology 2007;49(6):408-15.
2007: Kuipers Folkert; Stroeve Johanna H M; Caron Sandrine; Staels Bart
Bile acids, farnesoid X receptor, atherosclerosis and metabolic control.
Current opinion in lipidology 2007;18(3):289-97.
2007: Drouineaud Véronique; Sagot Paul; Garrido Carmen; Logette Emmanuelle; Deckert Valérie; Gambert Philippe; Jimenez Clément; Staels Bart; Lagrost Laurent; Masson David
Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists.
Molecular human reproduction 2007;13(6):373-9.
2007: Nakamachi Takafumi; Nomiyama Takashi; Gizard Florence; Heywood Elizabeth B; Jones Karrie L; Zhao Yue; Fuentes Lucia; Takebayashi Kohzo; Aso Yoshimasa; Staels Bart; Inukai Toshihiko; Bruemmer Dennis
PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 diabetes.
Diabetes 2007;56(6):1662-70.
2007: Paumelle Réjane; Staels Bart
Peroxisome proliferator-activated receptors mediate pleiotropic actions of statins.
Circulation research 2007;100(10):1394-5.
2007: Cariou Bertrand; Staels Bart
FXR: a promising target for the metabolic syndrome?
Trends in pharmacological sciences 2007;28(5):236-43.
2007: Flajollet Sébastien; Lefebvre Bruno; Cudejko Céline; Staels Bart; Lefebvre Philippe
The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor.
Molecular and cellular endocrinology 2007;270(1-2):23-32.
2007: Fontaine Coralie; Staels Bart
The orphan nuclear receptor Rev-erbalpha: a transcriptional link between circadian rhythmicity and cardiometabolic disease.
Current opinion in lipidology 2007;18(2):141-6.
2007: Blanc-Brude Olivier P; Teissier Elisabeth; Castier Yves; Lesèche Guy; Bijnens Ann-Pascal; Daemen Mat; Staels Bart; Mallat Ziad; Tedgui Alain
IAP survivin regulates atherosclerotic macrophage survival.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):901-7.
2007: Balmforth Anthony J; Grant Peter J; Scott Eleanor M; Wheatcroft Stephen B; Kearney Mark T; Staels Bart; Marx Nikolaus
Inter-subject differences in constitutive expression levels of the clock gene in man.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2007;4(1):39-43.
2007: Hondares Elayne; Pineda-Torra Inés; Iglesias Roser; Staels Bart; Villarroya Francesc; Giralt Marta
PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle.
Biochemical and biophysical research communications 2007;354(4):1021-7.
2007: Gervois Philippe; Fruchart Jean-Charles; Staels Bart
Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors.
Nature clinical practice. Endocrinology & metabolism 2007;3(2):145-56.
2007: Sharma Arya M; Staels Bart
Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism.
The Journal of clinical endocrinology and metabolism 2007;92(2):386-95.
2007: Staels Bart; Kuipers Folkert
Bile acid sequestrants and the treatment of type 2 diabetes mellitus.
Drugs 2007;67(10):1383-92.
2007: Fievet Catherine; Fruchart Jean-Charles; Staels Bart
Genetically-engineered animals as research models for atherosclerosis: their use for the characterization of PPAR agonists in the treatment of cardiometabolic disorders.
Frontiers in bioscience : a journal and virtual library 2007;12():4132-56.
2006: Michalik Liliane; Auwerx Johan; Berger Joel P; Chatterjee V Krishna; Glass Christopher K; Gonzalez Frank J; Grimaldi Paul A; Kadowaki Takashi; Lazar Mitchell A; O'Rahilly Stephen; Palmer Colin N A; Plutzky Jorge; Reddy Janardan K; Spiegelman Bruce M; Staels Bart; Wahli Walter
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
Pharmacological reviews 2006;58(4):726-41.
2006: Germain Pierre; Staels Bart; Dacquet Catherine; Spedding Michael; Laudet Vincent
Overview of nomenclature of nuclear receptors.
Pharmacological reviews 2006;58(4):685-704.
2006: Bordet R; Ouk T; Petrault O; Gelé P; Gautier S; Laprais M; Deplanque D; Duriez P; Staels B; Fruchart J C; Bastide M
PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases.
Biochemical Society transactions 2006;34(Pt 6):1341-6.
2006: Chinetti G; Fruchart J C; Staels B
Transcriptional regulation of macrophage cholesterol trafficking by PPARalpha and LXR.
Biochemical Society transactions 2006;34(Pt 6):1128-31.
2006: Post Sabine M; Groenendijk Martine; van der Hoogt Caroline C; Fievet Catherine; Luc Gérald; Hoekstra Menno; Princen Hans M G; Staels Bart; Rensen Patrick C N
Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(12):2724-30.
2006: Lalloyer Fanny; Fiévet Catherine; Lestavel Sophie; Torpier Gérard; van der Veen Jelske; Touche Véronique; Bultel Stéphanie; Yous Saïd; Kuipers Folkert; Paumelle Réjane; Fruchart Jean-Charles; Staels Bart; Tailleux Anne
The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(12):2731-7.
2006: Fiévet Catherine; Fruchart Jean-Charles; Staels Bart
PPARalpha and PPARgamma dual agonists for the treatment of type 2 diabetes and the metabolic syndrome.
Current opinion in pharmacology 2006;6(6):606-14.
2006: Blanc-Delmas Elodie; Lebegue Nicolas; Wallez Valérie; Leclerc Véronique; Yous Saïd; Carato Pascal; Farce Amaury; Bennejean Caroline; Renard Pierre; Caignard Daniel-Henri; Audinot-Bouchez Valérie; Chomarat Pascale; Boutin Jean; Hennuyer Nathalie; Louche Katie; Carmona Maria Carmen; Staels Bart; Pénicaud Luc; Casteilla Louis; Lonchampt Michel; Dacquet Catherine; Chavatte Philippe; Berthelot Pascal; Lesieur Daniel
Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists.
Bioorganic & medicinal chemistry 2006;14(22):7377-91.
2006: Gizard Florence; Robillard Romain; Gross Barbara; Barbier Olivier; Révillion Françoise; Peyrat Jean-Philippe; Torpier Gérard; Hum Dean W; Staels Bart
TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone.
Molecular and cellular biology 2006;26(20):7632-44.
2006: Cauchi Stéphane; Meyre David; Dina Christian; Choquet Hélène; Samson Chantal; Gallina Sophie; Balkau Beverley; Charpentier Guillaume; Pattou François; Stetsyuk Volodymyr; Scharfmann Raphaël; Staels Bart; Frühbeck Gema; Froguel Philippe
Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
Diabetes 2006;55(10):2903-8.
2006: Singaraja Roshni R; Van Eck Miranda; Bissada Nagat; Zimetti Francesca; Collins Heidi L; Hildebrand Reeni B; Hayden Anna; Brunham Liam R; Kang Martin H; Fruchart Jean-Charles; Van Berkel Theo J C; Parks John S; Staels Bart; Rothblat George H; Fiévet Catherine; Hayden Michael R
Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.
Circulation 2006;114(12):1301-9.
2006: Pourcet Benoit; Fruchart Jean-Charles; Staels Bart; Glineur Corine
Selective PPAR modulators, dual and pan PPAR agonists: multimodal drugs for the treatment of type 2 diabetes and atherosclerosis.
Expert opinion on emerging drugs 2006;11(3):379-401.
2006: Caron Sandrine; Cariou Bertrand; Staels Bart
FXR: More than a bile acid receptor?
Endocrinology 2006;147(9):4022-4.
2006: Basséne Carine Ekambomé; Suzenet Franck; Hennuyer Nathalie; Staels Bart; Caignard Daniel-Henri; Dacquet Catherine; Renard Pierre; Guillaumet Gérald
Studies towards the conception of new selective PPARbeta/delta ligands.
Bioorganic & medicinal chemistry letters 2006;16(17):4528-32.
2006: Verreault Mélanie; Senekeo-Effenberger Kathy; Trottier Jocelyn; Bonzo Jessica A; Bélanger Julie; Kaeding Jenny; Staels Bart; Caron Patrick; Tukey Robert H; Barbier Olivier
The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.
Hepatology (Baltimore, Md.) 2006;44(2):368-78.
2006: Lalloyer Fanny; Vandewalle Brigitte; Percevault Frédéric; Torpier Gérard; Kerr-Conte Julie; Oosterveer Maaike; Paumelle Réjane; Fruchart Jean-Charles; Kuipers Folkert; Pattou François; Fiévet Catherine; Staels Bart
Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.
Diabetes 2006;55(6):1605-13.
2006: Cariou Bertrand; Staels Bart
The expanding role of the bile acid receptor FXR in the small intestine.
Journal of hepatology 2006;44(6):1213-5.
2006: Froment P; Gizard F; Defever D; Staels B; Dupont J; Monget P
Peroxisome proliferator-activated receptors in reproductive tissues: from gametogenesis to parturition.
The Journal of endocrinology 2006;189(2):199-209.
2006: Zambon Alberto; Gervois Philippe; Pauletto Paolo; Fruchart Jean-Charles; Staels Bart
Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: clinical and experimental evidence.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(5):977-86.
2006: Sparatore Anna; Godio Cristina; Perrino Elena; Romeo Sergio; Staels Bart; Fruchart Jean-Charles; Crestani Maurizio
[4-(2H-1,2,3-benzotriazol-2-yl)phenoxy]alkanoic acids as agonists of peroxisome proliferator-activated receptors (PPARs).
Chemistry & biodiversity 2006;3(4):385-95.
2006: Zamble Alexis; Carpentier Marie; Kandoussi Abdelmejid; Sahpaz Sevser; Petrault Olivier; Ouk Tawarak; Hennuyer Nathalie; Fruchart Jean-Charles; Staels Bart; Bordet Régis; Duriez Patrick; Bailleul François; Martin-Nizard Françoise
Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms.
Journal of cardiovascular pharmacology 2006;47(4):599-608.
2006: Gizard Florence; Staels Bart
[The fibrate-activated PPARalpha/p16INK4A pathway inhibits vascular smooth muscle cell proliferation and vascular occlusion]
Médecine sciences : M/S 2006;22(4):351-3.
2006: Brunham Liam R; Kruit Janine K; Iqbal Jahangir; Fievet Catherine; Timmins Jenelle M; Pape Terry D; Coburn Bryan A; Bissada Nagat; Staels Bart; Groen Albert K; Hussain M Mahmood; Parks John S; Kuipers Folkert; Hayden Michael R
Intestinal ABCA1 directly contributes to HDL biogenesis in vivo.
The Journal of clinical investigation 2006;116(4):1052-62.
2006: Shiri-Sverdlov Ronit; Wouters Kristiaan; van Gorp Patrick J; Gijbels Marion J; Noel Benoit; Buffat Laurent; Staels Bart; Maeda Nobuyo; van Bilsen Marc; Hofker Marten H
Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates.
Journal of hepatology 2006;44(4):732-41.
2006: Cariou Bertrand; van Harmelen Kirsten; Duran-Sandoval Daniel; van Dijk Theo H; Grefhorst Aldo; Abdelkarim Mouaadh; Caron Sandrine; Torpier Gérard; Fruchart Jean-Charles; Gonzalez Frank J; Kuipers Folkert; Staels Bart
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice.
The Journal of biological chemistry 2006;281(16):11039-49.
2006: Meisner Franz; Walcher Daniel; Gizard Florence; Kapfer Xaver; Huber Roman; Noak Anja; Sunder-Plassmann Ludger; Bach Helga; Haug Cornelia; Bachem Max; Stojakovic Tatjana; März Winfried; Hombach Vinzenz; Koenig Wolfgang; Staels Bart; Marx Nikolaus
Effect of rosiglitazone treatment on plaque inflammation and collagen content in nondiabetic patients: data from a randomized placebo-controlled trial.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(4):845-50.
2006: Boukhtouche Fatiha; Vodjdani Guilan; Jarvis Christopher I; Bakouche Joelle; Staels Bart; Mallet Jacques; Mariani Jean; Lemaigre-Dubreuil Yolande; Brugg Bernard
Human retinoic acid receptor-related orphan receptor alpha1 overexpression protects neurones against oxidative stress-induced apoptosis.
Journal of neurochemistry 2006;96(6):1778-89.
2006: Lefebvre Philippe; Chinetti Giulia; Fruchart Jean-Charles; Staels Bart
Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis.
The Journal of clinical investigation 2006;116(3):571-80.
2006: Costet Philippe; Cariou Bertrand; Lambert Gilles; Lalanne Florent; Lardeux Bernard; Jarnoux Anne-Laure; Grefhorst Aldo; Staels Bart; Krempf Michel
Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c.
The Journal of biological chemistry 2006;281(10):6211-8.
2006: Duval Caroline; Touche Véronique; Tailleux Anne; Fruchart Jean-Charles; Fievet Catherine; Clavey Véronique; Staels Bart; Lestavel Sophie
Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine.
Biochemical and biophysical research communications 2006;340(4):1259-63.
2006: Paumelle Réjane; Blanquart Christophe; Briand Olivier; Barbier Olivier; Duhem Christian; Woerly Gaëtane; Percevault Frédéric; Fruchart Jean-Charles; Dombrowicz David; Glineur Corine; Staels Bart
Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-alpha via inhibition of the protein kinase C signaling pathway.
Circulation research 2006;98(3):361-9.
2006: Staels Bart
When the Clock stops ticking, metabolic syndrome explodes.
Nature medicine 2006;12(1):54-5; discussion 55.
2006: Staels Bart
Metformin and pioglitazone: Effectively treating insulin resistance.
Current medical research and opinion 2006;22 Suppl 2():S27-37.
2005: Schupp Michael; Clemenz Markus; Gineste Romain; Witt Henning; Janke Jürgen; Helleboid Stephane; Hennuyer Nathalie; Ruiz Patricia; Unger Thomas; Staels Bart; Kintscher Ulrich
Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity.
Diabetes 2005;54(12):3442-52.
2005: Lie Jessica; Lankhuizen Inge M; Gross Barbara; van Gent Teus; van Haperen Rien; Scheek Leo; Staels Bart; de Crom Rini; van Tol Arie
Fenofibrate reverses the decline in HDL cholesterol in mice overexpressing human phospholipid transfer protein.
Biochimica et biophysica acta 2005;1738(1-3):48-53.
2005: Chinetti-Gbaguidi G; Rigamonti E; Helin L; Mutka A L; Lepore M; Fruchart J C; Clavey V; Ikonen E; Lestavel S; Staels B
Peroxisome proliferator-activated receptor alpha controls cellular cholesterol trafficking in macrophages.
Journal of lipid research 2005;46(12):2717-25.
2005: De Bosscher Karolien; Vanden Berghe Wim; Beck Ilse M E; Van Molle Wim; Hennuyer Nathalie; Hapgood Janet; Libert Claude; Staels Bart; Louw Ann; Haegeman Guy
A fully dissociated compound of plant origin for inflammatory gene repression.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15827-32.
2005: Gizard Florence; Amant Carole; Barbier Olivier; Bellosta Stefano; Robillard Romain; Percevault Frédéric; Sevestre Henry; Krimpenfort Paul; Corsini Alberto; Rochette Jacques; Glineur Corine; Fruchart Jean-Charles; Torpier Gérard; Staels Bart
PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a.
The Journal of clinical investigation 2005;115(11):3228-38.
2005: Gizard Florence; Robillard Romain; Gervois Philippe; Faucompré Anne; Révillion Françoise; Peyrat Jean-Philippe; Hum W Dean; Staels Bart
Progesterone inhibits human breast cancer cell growth through transcriptional upregulation of the cyclin-dependent kinase inhibitor p27Kip1 gene.
FEBS letters 2005;579(25):5535-41.
2005: Claudel Thierry; Staels Bart; Kuipers Folkert
The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(10):2020-30.
2005: Chauvet Caroline; Bois-Joyeux Brigitte; Fontaine Coralie; Gervois Philippe; Bernard Marguerite-Anne; Staels Bart; Danan Jean-Louis
The gene encoding fibrinogen-beta is a target for retinoic acid receptor-related orphan receptor alpha.
Molecular endocrinology (Baltimore, Md.) 2005;19(10):2517-26.
2005: Rigamonti E; Helin L; Lestavel S; Mutka A L; Lepore M; Fontaine C; Bouhlel M A; Bultel S; Fruchart J C; Ikonen E; Clavey V; Staels B; Chinetti-Gbaguidi G
Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages.
Circulation research 2005;97(7):682-9.
2005: Chinetti-Gbaguidi Giulia; Fruchart Jean Charles; Staels Bart
Pleiotropic effects of fibrates.
Current atherosclerosis reports 2005;7(5):396-401.
2005: Hennuyer Nathalie; Tailleux Anne; Torpier Gérard; Mezdour Hafid; Fruchart Jean-Charles; Staels Bart; Fiévet Catherine
PPARalpha, but not PPARgamma, activators decrease macrophage-laden atherosclerotic lesions in a nondiabetic mouse model of mixed dyslipidemia.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(9):1897-902.
2005: Pinelli Alessandra; Godio Cristina; Laghezza Antonio; Mitro Nico; Fracchiolla Giuseppe; Tortorella Vincenzo; Lavecchia Antonio; Novellino Ettore; Fruchart Jean-Charles; Staels Bart; Crestani Maurizio; Loiodice Fulvio
Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.
Journal of medicinal chemistry 2005;48(17):5509-19.
2005: Staels Bart
Fluid retention mediated by renal PPARgamma.
Cell metabolism 2005;2(2):77-8.
2005: Staels Bart; Fruchart Jean-Charles
Therapeutic roles of peroxisome proliferator-activated receptor agonists.
Diabetes 2005;54(8):2460-70.
2005: Cariou Bertrand; van Harmelen Kirsten; Duran-Sandoval Daniel; van Dijk Theo; Grefhorst Aldo; Bouchaert Emmanuel; Fruchart Jean-Charles; Gonzalez Frank J; Kuipers Folkert; Staels Bart
Transient impairment of the adaptive response to fasting in FXR-deficient mice.
FEBS letters 2005;579(19):4076-80.
2005: Duran-Sandoval Daniel; Cariou Bertrand; Percevault Fredéric; Hennuyer Nathalie; Grefhorst Aldo; van Dijk Theo H; Gonzalez Frank J; Fruchart Jean-Charles; Kuipers Folkert; Staels Bart
The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition.
The Journal of biological chemistry 2005;280(33):29971-9.
2005: Gizard Florence; Robillard Romain; Barbier Olivier; Quatannens Brigitte; Faucompré Anne; Révillion Françoise; Peyrat Jean-Philippe; Staels Bart; Hum Dean W
TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1.
Molecular and cellular biology 2005;25(11):4335-48.
2005: Genoux Annelise; Dehondt Hélène; Helleboid-Chapman Audrey; Duhem Christian; Hum Dean W; Martin Geneviève; Pennacchio Len A; Staels Bart; Fruchart-Najib Jamila; Fruchart Jean-Charles
Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(6):1186-92.
2005: Coutinho Jonathan M; Singaraja Roshni R; Kang Martin; Arenillas David J; Bertram Lisa N; Bissada Nagat; Staels Bart; Fruchart Jean-Charles; Fievet Catherine; Joseph-George Ann M; Wasserman Wyeth W; Hayden Michael R
Complete functional rescue of the ABCA1-/- mouse by human BAC transgenesis.
Journal of lipid research 2005;46(6):1113-23.
2005: Froment Pascal; Gizard Florence; Staels Bart; Dupont Joëlle; Monget Philippe
[A role of PPARgamma in reproduction?]
Médecine sciences : M/S 2005;21(5):507-11.
2005: Bihan Hélène; Rouault Christine; Reach Gérard; Poitout Vincent; Staels Bart; Guerre-Millo Michèle
Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha).
FEBS letters 2005;579(11):2284-8.
2005: Chinetti-Gbaguidi Giulia; Fruchart Jean-Charles; Staels Bart
Role of the PPAR family of nuclear receptors in the regulation of metabolic and cardiovascular homeostasis: new approaches to therapy.
Current opinion in pharmacology 2005;5(2):177-83.
2005: Cariou Bertrand; Duran-Sandoval Daniel; Kuipers Folkert; Staels Bart
Farnesoid X receptor: a new player in glucose metabolism?
Endocrinology 2005;146(3):981-3.
2005: Duez Hélène; Lefebvre Bruno; Poulain Philippe; Torra Inés Pineda; Percevault Frédéric; Luc Gérald; Peters Jeffrey M; Gonzalez Frank J; Gineste Romain; Helleboid Stéphane; Dzavik Vladimir; Fruchart Jean-Charles; Fiévet Catherine; Lefebvre Philippe; Staels Bart
Regulation of human apoA-I by gemfibrozil and fenofibrate through selective peroxisome proliferator-activated receptor alpha modulation.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(3):585-91.
2005: van der Veen Jelske N; Kruit Janine K; Havinga Rick; Baller Julius F W; Chimini Giovanna; Lestavel Sophie; Staels Bart; Groot Pieter H E; Groen Albert K; Kuipers Folkert
Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.
Journal of lipid research 2005;46(3):526-34.
2005: Nowak Maxime; Helleboid-Chapman Audrey; Jakel Heidelinde; Martin Geneviève; Duran-Sandoval Daniel; Staels Bart; Rubin Edward M; Pennacchio Len A; Taskinen Marja-Riitta; Fruchart-Najib Jamila; Fruchart Jean-Charles
Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the phosphatidylinositol 3-kinase pathway: role of upstream stimulatory factor.
Molecular and cellular biology 2005;25(4):1537-48.
2005: Sandberg Maria B; Bloksgaard Maria; Duran-Sandoval Daniel; Duval Caroline; Staels Bart; Mandrup Susanne
The gene encoding acyl-CoA-binding protein is subject to metabolic regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes.
The Journal of biological chemistry 2005;280(7):5258-66.
2005: Duran-Sandoval Daniel; Cariou Bertrand; Fruchart Jean-Charles; Staels Bart
Potential regulatory role of the farnesoid X receptor in the metabolic syndrome.
Biochimie 2005;87(1):93-8.
2005: Desmet Christophe; Warzée Barbara; Gosset Philippe; Mélotte Dorothée; Rongvaux Anthony; Gillet Laurent; Fiévez Laurence; Seumois Grégory; Vanderplasschen Alain; Staels Bart; Lekeux Pierre; Bureau Fabrice
Pro-inflammatory properties for thiazolidinediones.
Biochemical pharmacology 2005;69(2):255-65.
2005: Barbier Olivier; Girard Hugo; Inoue Yusuke; Duez Hélène; Villeneuve Lyne; Kamiya Akihide; Fruchart Jean-Charles; Guillemette Chantal; Gonzalez Frank J; Staels Bart
Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha.
Molecular pharmacology 2005;67(1):241-9.
2005: Robillard R; Fontaine C; Chinetti G; Fruchart J C; Staels B
Fibrates.
Handbook of experimental pharmacology 2005;(170):389-406.
2004: Teissier Elisabeth; Nohara Atsushi; Chinetti Giulia; Paumelle Réjane; Cariou Bertrand; Fruchart Jean-Charles; Brandes Ralf P; Shah Ajay; Staels Bart
Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties.
Circulation research 2004;95(12):1174-82.
2004: Kuipers Folkert; Claudel Thierry; Sturm Ekkehard; Staels Bart
The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism.
Reviews in endocrine & metabolic disorders 2004;5(4):319-26.
2004: Sirvent Audrey; Verhoeven Adrie J M; Jansen Hans; Kosykh Vladimir; Darteil Raphaël J; Hum Dean W; Fruchart Jean-Charles; Staels Bart
Farnesoid X receptor represses hepatic lipase gene expression.
Journal of lipid research 2004;45(11):2110-5.
2004: Huss Janice M; Torra Inés Pineda; Staels Bart; Giguère Vincent; Kelly Daniel P
Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle.
Molecular and cellular biology 2004;24(20):9079-91.
2004: Landrier Jean-François; Thomas Charles; Grober Jacques; Duez Hélène; Percevault Frédéric; Souidi Maâmar; Linard Christine; Staels Bart; Besnard Philippe
Statin induction of liver fatty acid-binding protein (L-FABP) gene expression is peroxisome proliferator-activated receptor-alpha-dependent.
The Journal of biological chemistry 2004;279(44):45512-8.
2004: Temelkova-Kurktschiev Theodora; Hanefeld Markolf; Chinetti Giulia; Zawadzki Christophe; Haulon Stephan; Kubaszek Agata; Koehler Carsta; Leonhardt Wolfgang; Staels Bart; Laakso Markku
Ala12Ala genotype of the peroxisome proliferator-activated receptor gamma2 protects against atherosclerosis.
The Journal of clinical endocrinology and metabolism 2004;89(9):4238-42.
2004: Barbier Olivier; Fontaine Coralie; Fruchart Jean-Charles; Staels Bart
Genomic and non-genomic interactions of PPARalpha with xenobiotic-metabolizing enzymes.
Trends in endocrinology and metabolism: TEM 2004;15(7):324-30.
2004: Claudel Thierry; Sturm Ekkehard; Kuipers Folkert; Staels Bart
The farnesoid X receptor: a novel drug target?
Expert opinion on investigational drugs 2004;13(9):1135-48.
2004: Blanquart Christophe; Mansouri Roxane; Paumelle Réjane; Fruchart Jean-Charles; Staels Bart; Glineur Corine
The protein kinase C signaling pathway regulates a molecular switch between transactivation and transrepression activity of the peroxisome proliferator-activated receptor alpha.
Molecular endocrinology (Baltimore, Md.) 2004;18(8):1906-18.
2004: Blanquart Christophe; Mansouri Roxane; Fruchart Jean-Charles; Staels Bart; Glineur Corine
Different ways to regulate the PPARalpha stability.
Biochemical and biophysical research communications 2004;319(2):663-70.
2004: Sirvent Audrey; Claudel Thierry; Martin Geneviève; Brozek John; Kosykh Vladimir; Darteil Raphaël; Hum Dean W; Fruchart Jean-Charles; Staels Bart
The farnesoid X receptor induces very low density lipoprotein receptor gene expression.
FEBS letters 2004;566(1-3):173-7.
2004: Marx Nikolaus; Duez Hélène; Fruchart Jean-Charles; Staels Bart
Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells.
Circulation research 2004;94(9):1168-78.
2004: Paterson Janice M; Morton Nicholas M; Fievet Catherine; Kenyon Christopher J; Holmes Megan C; Staels Bart; Seckl Jonathan R; Mullins John J
Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7088-93.
2004: Mavri Alenka; Bastelica Delphine; Staels Bart; El Ayachi Soulaf; Juhan-Vague Irène; Alessi Marie-Christine
PPARalpha deficiency does not modify age dependency but prevents high fat diet increase in plasma PAI-1 as well as insulin resistance.
Thrombosis and haemostasis 2004;91(5):1051-2.
2004: Gizard F; Teissier E; Dufort I; Luc G; Luu-The V; Staels B; Hum D W
The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells.
Journal of molecular endocrinology 2004;32(2):557-69.
2004: Watts Gerald F; Staels Bart
Regulation of endothelial nitric oxide synthase by PPAR agonists: molecular and clinical perspectives.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(4):619-21.
2004: Morton Nicholas M; Paterson Janice M; Masuzaki Hiroaki; Holmes Megan C; Staels Bart; Fievet Catherine; Walker Brian R; Flier Jeffrey S; Mullins John J; Seckl Jonathan R
Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.
Diabetes 2004;53(4):931-8.
2004: Duran-Sandoval Daniel; Mautino Gisèle; Martin Geneviève; Percevault Fréderic; Barbier Olivier; Fruchart Jean-Charles; Kuipers Folkert; Staels Bart
Glucose regulates the expression of the farnesoid X receptor in liver.
Diabetes 2004;53(4):890-8.
2004: Gervois Philippe; Kleemann Robert; Pilon Antoine; Percevault Frédéric; Koenig Wolfgang; Staels Bart; Kooistra Teake
Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate.
The Journal of biological chemistry 2004;279(16):16154-60.
2004: Hofker M; Calabresi L; Jauhiainen M; Nimpf J; Rudling M; Talmud P; Mooser V; Dallinga-Thie G; von Eckardstein A; Staels B; Karpe F; Kuipers F
European Lipoprotein Club: report of the 26th ELC Annual Conference, Tutzing, 8-11 September 2003.
Atherosclerosis 2004;173(1):125-34.
2004: Luc Gérald; Jacob Nelly; Bouly Muriel; Fruchart Jean-Charles; Staels Bart; Giral Philippe
Fenofibrate increases homocystinemia through a PPARalpha-mediated mechanism.
Journal of cardiovascular pharmacology 2004;43(3):452-3.
2004: Bandsma Robert H J; Van Dijk Theo H; Harmsel At Anke ter; Kok Tineke; Reijngoud Dirk-Jan; Staels Bart; Kuipers Folkert
Hepatic de novo synthesis of glucose 6-phosphate is not affected in peroxisome proliferator-activated receptor alpha-deficient mice but is preferentially directed toward hepatic glycogen stores after a short term fast.
The Journal of biological chemistry 2004;279(10):8930-7.
2004: Masson David; Staels Bart; Gautier Thomas; Desrumaux Catherine; Athias Anne; Le Guern Naig; Schneider Martina; Zak Zoulika; Dumont Laure; Deckert Valérie; Tall Alan; Jiang Xian-Cheng; Lagrost Laurent
Cholesteryl ester transfer protein modulates the effect of liver X receptor agonists on cholesterol transport and excretion in the mouse.
Journal of lipid research 2004;45(3):543-50.
2004: Martin Geneviève; Dol Frédérique; Marés Anne-Marie; Berezowski Vincent; Staels Bart; Hum Dean W; Schaeffer Paul; Herbert Jean-Marc
Lesion progression in apoE-deficient mice: implication of chemokines and effect of the AT1 angiotensin II receptor antagonist irbesartan.
Journal of cardiovascular pharmacology 2004;43(2):191-9.
2004: Meissner Markus; Stein Monika; Urbich Carmen; Reisinger Kerstin; Suske Guntram; Staels Bart; Kaufmann Roland; Gille Jens
PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transactivation.
Circulation research 2004;94(3):324-32.
2003: Westergaard Majken; Henningsen Jeanette; Johansen Claus; Rasmussen Sofie; Svendsen Morten Lyhne; Jensen Uffe Birk; Schrøder Henrik Daa; Staels Bart; Iversen Lars; Bolund Lars; Kragballe Knud; Kristiansen Karsten
Expression and localization of peroxisome proliferator-activated receptors and nuclear factor kappaB in normal and lesional psoriatic skin.
The Journal of investigative dermatology 2003;121(5):1104-17.
2003: Froment Pascal; Fabre Stephane; Dupont Joelle; Pisselet Claudine; Chesneau Didier; Staels Bart; Monget Philippe
Expression and functional role of peroxisome proliferator-activated receptor-gamma in ovarian folliculogenesis in the sheep.
Biology of reproduction 2003;69(5):1665-74.
2003: Tailleux Anne; Torpier Gérard; Mezdour Hafid; Fruchart Jean-Charles; Staels Bart; Fiévet Catherine
Murine models to investigate pharmacological compounds acting as ligands of PPARs in dyslipidemia and atherosclerosis.
Trends in pharmacological sciences 2003;24(10):530-4.
2003: Chinetti Giulia; Fruchart Jean-Charles; Staels Bart
Peroxisome proliferator-activated receptors: new targets for the pharmacological modulation of macrophage gene expression and function.
Current opinion in lipidology 2003;14(5):459-68.
2003: Fontaine Coralie; Dubois Guillaume; Duguay Yannick; Helledie Torben; Vu-Dac Ngoc; Gervois Philippe; Soncin Fabrice; Mandrup Susanne; Fruchart Jean-Charles; Fruchart-Najib Jamila; Staels Bart
The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation.
The Journal of biological chemistry 2003;278(39):37672-80.
2003: Duran-Sandoval Daniel; Thomas Anne-Claire; Bailleul Bernard; Fruchart Jean-Charles; Staels Bart
[Pharmacology of PPARalpha, PPARgamma and dual PPARalpha/gamma agonists in clinical development]
Médecine sciences : M/S 2003;19(8-9):819-25.
2003: Woerly Gaetane; Honda Kohei; Loyens Marc; Papin Jean-Paul; Auwerx Johan; Staels Bart; Capron Monique; Dombrowicz David
Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation.
The Journal of experimental medicine 2003;198(3):411-21.
2003: Claudel Thierry; Inoue Yusuke; Barbier Olivier; Duran-Sandoval Daniel; Kosykh Vladimir; Fruchart Jamila; Fruchart Jean-Charles; Gonzalez Frank J; Staels Bart
Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.
Gastroenterology 2003;125(2):544-55.
2003: Barbier Olivier; Duran-Sandoval Daniel; Pineda-Torra Inés; Kosykh Vladimir; Fruchart Jean-Charles; Staels Bart
Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme.
The Journal of biological chemistry 2003;278(35):32852-60.
2003: Deplanque Dominique; Gelé Patrick; Pétrault Olivier; Six Isabelle; Furman Christophe; Bouly Muriel; Nion Stéphane; Dupuis Bernard; Leys Didier; Fruchart Jean-Charles; Cecchelli Roméo; Staels Bart; Duriez Patrick; Bordet Régis
Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(15):6264-71.
2003: Blanquart Christophe; Barbier Olivier; Fruchart Jean Charles; Staels Bart; Glineur Corine
Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation.
The Journal of steroid biochemistry and molecular biology 2003;85(2-5):267-73.
2003: Barbier Olivier; Torra Ines Pineda; Sirvent Audrey; Claudel Thierry; Blanquart Christophe; Duran-Sandoval Daniel; Kuipers Folkert; Kosykh Vladimir; Fruchart Jean-Charles; Staels Bart
FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity.
Gastroenterology 2003;124(7):1926-40.
2003: Angeli Véronique; Hammad Hamida; Staels Bart; Capron Monique; Lambrecht Bart N; Trottein François
Peroxisome proliferator-activated receptor gamma inhibits the migration of dendritic cells: consequences for the immune response.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):5295-301.
2003: Pellegatta Fabio; Bertelli Alberto A E; Staels Bart; Duhem Christian; Fulgenzi Alessandro; Ferrero Maria Elena
Different short- and long-term effects of resveratrol on nuclear factor-kappaB phosphorylation and nuclear appearance in human endothelial cells.
The American journal of clinical nutrition 2003;77(5):1220-8.
2003: Vu-Dac Ngoc; Gervois Philippe; Jakel Heidi; Nowak Maxime; Bauge Eric; Dehondt Helene; Staels Bart; Pennacchio Len A; Rubin Edward M; Fruchart-Najib Jamila; Fruchart Jean-Charles
Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators.
The Journal of biological chemistry 2003;278(20):17982-5.
2003: Pilon Antoine; Martin Geneviève; Bultel-Brienne Stéphanie; Junquero Didier; Delhon André; Fruchart Jean-Charles; Staels Bart; Clavey Véronique
Regulation of the scavenger receptor BI and the LDL receptor by activators of aldosterone production, angiotensin II and PMA, in the human NCI-H295R adrenocortical cell line.
Biochimica et biophysica acta 2003;1631(3):218-28.
2003: Bocher Virginie; Millatt Lesley J; Fruchart Jean-Charles; Staels Bart
Liver X receptors: new players in atherogenesis?
Current opinion in lipidology 2003;14(2):137-43.
2003: Cullen Paul; Baetta Roberta; Bellosta Stefano; Bernini Franco; Chinetti Giulia; Cignarella Andrea; von Eckardstein Arnold; Exley Andrew; Goddard Martin; Hofker Marten; Hurt-Camejo Eva; Kanters Edwin; Kovanen Petri; Lorkowski Stefan; McPheat William; Pentikäinen Markku; Rauterberg Jürgen; Ritchie Andrew; Staels Bart; Weitkamp Benedikt; de Winther Menno;
Rupture of the atherosclerotic plaque: does a good animal model exist?
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):535-42.
2003: Barbier Olivier; Villeneuve Lyne; Bocher Virginie; Fontaine Coralie; Torra Ines Pineda; Duhem Christian; Kosykh Vladimir; Fruchart Jean-Charles; Guillemette Chantal; Staels Bart
The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene.
The Journal of biological chemistry 2003;278(16):13975-83.
2003: Millatt Lesley J; Bocher Virginie; Fruchart Jean Charles; Staels Bart
Liver X receptors and the control of cholesterol homeostasis: potential therapeutic targets for the treatment of atherosclerosis.
Biochimica et biophysica acta 2003;1631(2):107-18.
2003: Johansson Marie; Bocher Virginie; Lehto Markku; Chinetti Giulia; Kuismanen Esa; Ehnholm Christian; Staels Bart; Olkkonen Vesa M
The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct.
Molecular biology of the cell 2003;14(3):903-15.
2003: Bowyer David; Dallinga-Thie Geesje; von Eckardstein Arnold; Hofker Marten; Jauhiainen Matti; Mooser Vincent; Nimpf Johannes; Rudling Matts; Staels Bart; Talmud Philippa
European lipoprotein club: report of the 25th ELC annual conference. Tutzing, 9-12 September 2002.
Atherosclerosis 2003;167(1):159-68.
2003: Gilde Andries J; van der Lee Karin A J M; Willemsen Peter H M; Chinetti Giulia; van der Leij Feike R; van der Vusse Ger J; Staels Bart; van Bilsen Marc
Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism.
Circulation research 2003;92(5):518-24.
2003: Mardones Pablo; Pilon Antoine; Bouly Muriel; Duran Daniel; Nishimoto Takako; Arai Hiroyuki; Kozarsky Karen F; Altayo Marcela; Miquel Juan Francisco; Luc Gerald; Clavey Veronique; Staels Bart; Rigotti Attilio
Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice.
The Journal of biological chemistry 2003;278(10):7884-90.
2003: Pineda Torra Inés; Claudel Thierry; Duval Caroline; Kosykh Vladimir; Fruchart Jean-Charles; Staels Bart
Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.
Molecular endocrinology (Baltimore, Md.) 2003;17(2):259-72.
2003: Kok Tineke; Bloks Vincent W; Wolters Henk; Havinga Rick; Jansen Peter L M; Staels Bart; Kuipers Folkert
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.
The Biochemical journal 2003;369(Pt 3):539-47.
2003: Kok Tineke; Wolters Henk; Bloks Vincent W; Havinga Rick; Jansen Peter L M; Staels Bart; Kuipers Folkert
Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse.
Gastroenterology 2003;124(1):160-71.
2003: Devos Sabrina; De Bosscher Karolien; Staels Bart; Bauer Ellinor; Roels Frank; Berghe WimVanden; Haegeman Guy; Hooghe Robert; Hooghe-Peters Elisabeth L
Inhibition of cytokine production by the herbicide atrazine. Search for nuclear receptor targets.
Biochemical pharmacology 2003;65(2):303-8.
2003: Kleemann Robert; Gervois Philippe P; Verschuren Lars; Staels Bart; Princen Hans M G; Kooistra Teake
Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation.
Blood 2003;101(2):545-51.
2003: Laitinen Saara; Staels Bart
Potential roles of ROR-alpha in cardiovascular endocrinology.
Nuclear receptor signaling 2003;1():e011.
2003: Vanden Berghe Wim; Vermeulen Linda; Delerive Philippe; De Bosscher Karolien; Staels Bart; Haegeman Guy
A paradigm for gene regulation: inflammation, NF-kappaB and PPAR.
Advances in experimental medicine and biology 2003;544():181-96.
2002: Raspé Eric; Duez Hélène; Mansén Anethe; Fontaine Coralie; Fiévet Catherine; Fruchart Jean-Charles; Vennström Bjorn; Staels Bart
Identification of Rev-erbalpha as a physiological repressor of apoC-III gene transcription.
Journal of lipid research 2002;43(12):2172-9.
2002: Martin-Nizard F; Furman C; Delerive P; Kandoussi A; Fruchart J C; Staels B; Duriez P
Peroxisome proliferator-activated receptor activators inhibit oxidized low-density lipoprotein-induced endothelin-1 secretion in endothelial cells.
Journal of cardiovascular pharmacology 2002;40(6):822-31.
2002: Duez Hélène; Chao Yu-Sheng; Hernandez Melba; Torpier Gérard; Poulain Philippe; Mundt Steven; Mallat Ziad; Teissier Elisabeth; Burton Charlotte A; Tedgui Alain; Fruchart Jean-Charles; Fiévet Catherine; Wright Sam D; Staels Bart
Reduction of atherosclerosis by the peroxisome proliferator-activated receptor alpha agonist fenofibrate in mice.
The Journal of biological chemistry 2002;277(50):48051-7.
2002: Raspè Eric; Mautino Gisèle; Duval Caroline; Fontaine Coralie; Duez Hélène; Barbier Olivier; Monte Didier; Fruchart Jamila; Fruchart Jean-Charles; Staels Bart
Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha.
The Journal of biological chemistry 2002;277(51):49275-81.
2002: Gizard Florence; El-Alfy Mohamed; Duguay Yannick; Lavallée Bernard; DeWitte Fredérique; Staels Bart; Beatty Barbara G; Hum Dean W
Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression.
Endocrine research 2002;28(4):559-74.
2002: Kintscher Ulrich; Lyon Christopher; Wakino Shu; Bruemmer Dennis; Feng Xu; Goetze Stephan; Graf Kristof; Moustakas Aristidis; Staels Bart; Fleck Eckart; Hsueh Willa A; Law Ronald E
PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4.
Circulation research 2002;91(11):e35-44.
2002: Blanquart Christophe; Barbier Olivier; Fruchart Jean-Charles; Staels Bart; Glineur Corine
Peroxisome proliferator-activated receptor alpha (PPARalpha ) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes.
The Journal of biological chemistry 2002;277(40):37254-9.
2002: Gizard Florence; Lavallee Bernard; DeWitte Frederique; Teissier Elisabeth; Staels Bart; Hum Dean W
The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells.
The Journal of biological chemistry 2002;277(42):39144-55.
2002: Clément Lionel; Poirier Hélène; Niot Isabelle; Bocher Virginie; Guerre-Millo Michèle; Krief Stéphane; Staels Bart; Besnard Philippe
Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse.
Journal of lipid research 2002;43(9):1400-9.
2002: Duval Caroline; Chinetti Giulia; Trottein Francois; Fruchart Jean-Charles; Staels Bart
The role of PPARs in atherosclerosis.
Trends in molecular medicine 2002;8(9):422-30.
2002: Meir Karen; Kitsberg Daniel; Alkalay Irit; Szafer Fanny; Rosen Haim; Shpitzen Shoshanna; Avi Liat Ben; Staels Bart; Fievet Catherine; Meiner Vardiella; Björkhem Ingemar; Leitersdorf Eran
Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis.
The Journal of biological chemistry 2002;277(37):34036-41.
2002: Kandoussi Abdelmejid; Martin François; Hazzan Marc; Noël Christian; Fruchart Jean-Charles; Staels Bart; Duriez Patrick
HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells.
Clinical science (London, England : 1979) 2002;103 Suppl 48():81S-83S.
2002: Darteil Raphaël; Wang Manping; Latta-Mahieu Martine; Caron Anne; Mahfoudi Abderrahim; Staels Bart; Thuillier Vincent
Efficient gene regulation by PPAR gamma and thiazolidinediones in skeletal muscle and heart.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(2):265-71.
2002: Singaraja Roshni R; Fievet Catherine; Castro Graciela; James Erick R; Hennuyer Nathalie; Clee Susanne M; Bissada Nagat; Choy Jonathan C; Fruchart Jean-Charles; McManus Bruce M; Staels Bart; Hayden Michael R
Increased ABCA1 activity protects against atherosclerosis.
The Journal of clinical investigation 2002;110(1):35-42.
2002: Bocher Virginie; Pineda-Torra Ines; Fruchart Jean-Charles; Staels Bart
PPARs: transcription factors controlling lipid and lipoprotein metabolism.
Annals of the New York Academy of Sciences 2002;967():7-18.
2002: Staels Bart
Cardiovascular biology: a cholesterol tether.
Nature 2002;417(6890):699-701.
2002: Dallinga-Thie G; Bowyer David; Dallinga-Thie Geesge; Dieplinger Hans; Funke Harald; Hofker Marten; Jauhiainen Matti; Nimpf Johannes; Staels Bart; Talmud Philippa; Tarugi Patricia
European Lipoprotein Club: Report of the 24th ELC Annual Conference, Tutzing, 10-13 September 2001.
Atherosclerosis 2002;162(2):439-47.
2002: Barbier O; Torra I Pineda; Duguay Y; Blanquart C; Fruchart J-C; Glineur C; Staels B
Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(5):717-26.
2002: Delerive Philippe; De Bosscher Karolien; Vanden Berghe Wim; Fruchart Jean-Charles; Haegeman Guy; Staels Bart
DNA binding-independent induction of IkappaBalpha gene transcription by PPARalpha.
Molecular endocrinology (Baltimore, Md.) 2002;16(5):1029-39.
2002: Pineda Torra Inés; Jamshidi Yalda; Flavell David M; Fruchart Jean-Charles; Staels Bart
Characterization of the human PPARalpha promoter: identification of a functional nuclear receptor response element.
Molecular endocrinology (Baltimore, Md.) 2002;16(5):1013-28.
2002: Khandoudi Nassirah; Delerive Philippe; Berrebi-Bertrand Isabelle; Buckingham Robin E; Staels Bart; Bril Antoine
Rosiglitazone, a peroxisome proliferator-activated receptor-gamma, inhibits the Jun NH(2)-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injury.
Diabetes 2002;51(5):1507-14.
2002: Madsen Lise; Guerre-Millo Michéle; Flindt Esben N; Berge Kjetil; Tronstad Karl Johan; Bergene Elin; Sebokova Elena; Rustan Arild C; Jensen Jørgen; Mandrup Susanne; Kristiansen Karsten; Klimes Iwar; Staels Bart; Berge Rolf K
Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance.
Journal of lipid research 2002;43(5):742-50.
2002: Claudel Thierry; Sturm Ekkehard; Duez Hélène; Torra Inés Pineda; Sirvent Audrey; Kosykh Vladimir; Fruchart Jean-Charles; Dallongeville Jean; Hum Dean W; Kuipers Folkert; Staels Bart
Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.
The Journal of clinical investigation 2002;109(7):961-71.
2002: Flavell David M; Jamshidi Yalda; Hawe Emma; Pineda Torra Inés; Taskinen Marja-Riitta; Frick M Heikki; Nieminen Markku S; Kesäniemi Y Antero; Pasternack Amos; Staels Bart; Miller George; Humphries Steve E; Talmud Philippa J; Syvänne Mikko
Peroxisome proliferator-activated receptor alpha gene variants influence progression of coronary atherosclerosis and risk of coronary artery disease.
Circulation 2002;105(12):1440-5.
2002: Bellosta S; Bernini F; Chinetti G; Cignarella A; Cullen P; von Eckardstein A; Exley A; Freeth J; Goddard M; Hofker M; Kanters E; Kovanen P; Lorkowski S; Pentikäinen M; Printen J; Rauterberg J; Ritchie A; Staels B; Weitkamp B; de Winther M;
Macrophage function and stability of the atherosclerotic plaque: progress report of a European project.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2002;12(1):3-11.
2002: Jamshidi Yalda; Montgomery Hugh E; Hense Hans-Werner; Myerson Saul G; Torra Ines Pineda; Staels Bart; World Michael J; Doering Angela; Erdmann Jeanette; Hengstenberg Christian; Humphries Steve E; Schunkert Heribert; Flavell David M
Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension.
Circulation 2002;105(8):950-5.
2002: Gbaguidi F G; Chinetti G; Milosavljevic D; Teissier E; Chapman J; Olivecrona G; Fruchart J C; Griglio S; Fruchart-Najib J; Staels B
Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages.
FEBS letters 2002;512(1-3):85-90.
2002: Jarvis Christopher I; Staels Bart; Brugg Bernard; Lemaigre-Dubreuil Yolande; Tedgui Alain; Mariani Jean
Age-related phenotypes in the staggerer mouse expand the RORalpha nuclear receptor's role beyond the cerebellum.
Molecular and cellular endocrinology 2002;186(1):1-5.
2002: Sturm E; Franssen C F M; Gouw A; Staels B; Boverhof R; De Knegt R J; Stellaard F; Bijleveld C M A; Kuipers F
Extracorporal albumin dialysis (MARS) improves cholestasis and normalizes low apo A-I levels in a patient with benign recurrent intrahepatic cholestasis (BRIC).
Liver 2002;22 Suppl 2():72-5.
2002: Bocher Virginie; Chinetti Giulia; Fruchart Jean-Charles; Staels Bart
[Role of the peroxisome proliferator-activated receptors (PPARS) in the regulation of lipids and inflammation control]
Journal de la Société de biologie 2002;196(1):47-52.
2001: Guerre-Millo M; Rouault C; Poulain P; André J; Poitout V; Peters J M; Gonzalez F J; Fruchart J C; Reach G; Staels B
PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance.
Diabetes 2001;50(12):2809-14.
2001: Post S M; Duez H; Gervois P P; Staels B; Kuipers F; Princen H M
Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1840-5.
2001: Morton N M; Holmes M C; Fiévet C; Staels B; Tailleux A; Mullins J J; Seckl J R
Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice.
The Journal of biological chemistry 2001;276(44):41293-300.
2001: Akiyama T E; Nicol C J; Fievet C; Staels B; Ward J M; Auwerx J; Lee S S; Gonzalez F J; Peters J M
Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines.
The Journal of biological chemistry 2001;276(42):39088-93.
2001: Dol F; Martin G; Staels B; Mares A M; Cazaubon C; Nisato D; Bidouard J P; Janiak P; Schaeffer P; Herbert J M
Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice.
Journal of cardiovascular pharmacology 2001;38(3):395-405.
2001: Singaraja R R; Bocher V; James E R; Clee S M; Zhang L H; Leavitt B R; Tan B; Brooks-Wilson A; Kwok A; Bissada N; Yang Y Z; Liu G; Tafuri S R; Fievet C; Wellington C L; Staels B; Hayden M R
Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1.
The Journal of biological chemistry 2001;276(36):33969-79.
2001: Gervois P; Vu-Dac N; Kleemann R; Kockx M; Dubois G; Laine B; Kosykh V; Fruchart J C; Kooistra T; Staels B
Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta.
The Journal of biological chemistry 2001;276(36):33471-7.
2001: Lehto M; Laitinen S; Chinetti G; Johansson M; Ehnholm C; Staels B; Ikonen E; Olkkonen V M
The OSBP-related protein family in humans.
Journal of lipid research 2001;42(8):1203-13.
2001: Bouly M; Masson D; Gross B; Jiang X C; Fievet C; Castro G; Tall A R; Fruchart J C; Staels B; Lagrost L; Luc G
Induction of the phospholipid transfer protein gene accounts for the high density lipoprotein enlargement in mice treated with fenofibrate.
The Journal of biological chemistry 2001;276(28):25841-7.
2001: Martin G; Duez H; Blanquart C; Berezowski V; Poulain P; Fruchart J C; Najib-Fruchart J; Glineur C; Staels B
Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I.
The Journal of clinical investigation 2001;107(11):1423-32.
2001: Delerive P; Fruchart J C; Staels B
Peroxisome proliferator-activated receptors in inflammation control.
The Journal of endocrinology 2001;169(3):453-9.
2001: Torra I P; Chinetti G; Duval C; Fruchart J C; Staels B
Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice.
Current opinion in lipidology 2001;12(3):245-54.
2001: Junquero D; Pilon A; Carilla-Durand E; Patoiseau J F; Tarayre J P; Torpier G; Staels B; Fruchart J C; Colpaert F C; Clavey V; Delhon A
Lack of toxic effects of F 12511, a novel potent inhibitor of acyl-coenzyme A: cholesterol O-acyltransferase, on human adrenocortical cells in culture.
Biochemical pharmacology 2001;61(4):387-98.
2001: Delerive P; Monté D; Dubois G; Trottein F; Fruchart-Najib J; Mariani J; Fruchart J C; Staels B
The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response.
EMBO reports 2001;2(1):42-8.
2001: Neve B P; Corseaux D; Chinetti G; Zawadzki C; Fruchart J C; Duriez P; Staels B; Jude B
PPARalpha agonists inhibit tissue factor expression in human monocytes and macrophages.
Circulation 2001;103(2):207-12.
2001: Chinetti G; Lestavel S; Bocher V; Remaley A T; Neve B; Torra I P; Teissier E; Minnich A; Jaye M; Duverger N; Brewer H B; Fruchart J C; Clavey V; Staels B
PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway.
Nature medicine 2001;7(1):53-8.
2001: Raspé E; Duez H; Gervois P; Fiévet C; Fruchart J C; Besnard S; Mariani J; Tedgui A; Staels B
Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha.
The Journal of biological chemistry 2001;276(4):2865-71.
2001: Bocher V; Chinetti G; Fruchart J C; Staels B
[PPARs activators and regulation of lipid metabolism, vascular inflammation and atherosclerosis]
Journées annuelles de diabétologie de l'Hôtel-Dieu 2001;():23-32.
2000: Faveeuw C; Fougeray S; Angeli V; Fontaine J; Chinetti G; Gosset P; Delerive P; Maliszewski C; Capron M; Staels B; Moser M; Trottein F
Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells.
FEBS letters 2000;486(3):261-6.
2000: Delerive P; Gervois P; Fruchart J C; Staels B
Induction of IkappaBalpha expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-alpha activators.
The Journal of biological chemistry 2000;275(47):36703-7.
2000: Torra I P; Tsibulsky V; Delaunay F; Saladin R; Laudet V; Fruchart J C; Kosykh V; Staels B
Circadian and glucocorticoid regulation of Rev-erbalpha expression in liver.
Endocrinology 2000;141(10):3799-806.
2000: Neve B P; Fruchart J C; Staels B
Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis.
Biochemical pharmacology 2000;60(8):1245-50.
2000: Guerre-Millo M; Gervois P; Raspé E; Madsen L; Poulain P; Derudas B; Herbert J M; Winegar D A; Willson T M; Fruchart J C; Berge R K; Staels B
Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity.
The Journal of biological chemistry 2000;275(22):16638-42.
2000: Flavell D M; Pineda Torra I; Jamshidi Y; Evans D; Diamond J R; Elkeles R S; Bujac S R; Miller G; Talmud P J; Staels B; Humphries S E
Variation in the PPARalpha gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects.
Diabetologia 2000;43(5):673-80.
2000: Chinetti G; Gbaguidi F G; Griglio S; Mallat Z; Antonucci M; Poulain P; Chapman J; Fruchart J C; Tedgui A; Najib-Fruchart J; Staels B
CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors.
Circulation 2000;101(20):2411-7.
2000: Delerive P; Furman C; Teissier E; Fruchart J; Duriez P; Staels B
Oxidized phospholipids activate PPARalpha in a phospholipase A2-dependent manner.
FEBS letters 2000;471(1):34-8.
1999: Bernard C; Merval R; Lebret M; Delerive P; Dusanter-Fourt I; Lehoux S; Créminon C; Staels B; Maclouf J; Tedgui A
Oncostatin M induces interleukin-6 and cyclooxygenase-2 expression in human vascular smooth muscle cells : synergy with interleukin-1beta.
Circulation research 1999;85(12):1124-31.
1999: Raspé E; Madsen L; Lefebvre A M; Leitersdorf I; Gelman L; Peinado-Onsurbe J; Dallongeville J; Fruchart J C; Berge R; Staels B
Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARalpha activation.
Journal of lipid research 1999;40(11):2099-110.
1999: Delerive P; De Bosscher K; Besnard S; Vanden Berghe W; Peters J M; Gonzalez F J; Fruchart J C; Tedgui A; Haegeman G; Staels B
Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1.
The Journal of biological chemistry 1999;274(45):32048-54.
1999: Mallat Z; Besnard S; Duriez M; Deleuze V; Emmanuel F; Bureau M F; Soubrier F; Esposito B; Duez H; Fievet C; Staels B; Duverger N; Scherman D; Tedgui A
Protective role of interleukin-10 in atherosclerosis.
Circulation research 1999;85(8):e17-24.
1999: Gervois P; Torra I P; Chinetti G; Grötzinger T; Dubois G; Fruchart J C; Fruchart-Najib J; Leitersdorf E; Staels B
A truncated human peroxisome proliferator-activated receptor alpha splice variant with dominant negative activity.
Molecular endocrinology (Baltimore, Md.) 1999;13(9):1535-49.
1999: Delerive P; Martin-Nizard F; Chinetti G; Trottein F; Fruchart J C; Najib J; Duriez P; Staels B
Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway.
Circulation research 1999;85(5):394-402.
1999: Hennuyer N; Poulain P; Madsen L; Berge R K; Houdebine L M; Branellec D; Fruchart J C; Fiévet C; Duverger N; Staels B
Beneficial effects of fibrates on apolipoprotein A-I metabolism occur independently of any peroxisome proliferative response.
Circulation 1999;99(18):2445-51.
1999: Kockx M; Gervois P P; Poulain P; Derudas B; Peters J M; Gonzalez F J; Princen H M; Kooistra T; Staels B
Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha.
Blood 1999;93(9):2991-8.
1999: Pineda Torra I; Gervois P; Staels B
Peroxisome proliferator-activated receptor alpha in metabolic disease, inflammation, atherosclerosis and aging.
Current opinion in lipidology 1999;10(2):151-9.
1999: Martin G; Pilon A; Albert C; Vallé M; Hum D W; Fruchart J C; Najib J; Clavey V; Staels B
Comparison of expression and regulation of the high-density lipoprotein receptor SR-BI and the low-density lipoprotein receptor in human adrenocortical carcinoma NCI-H295 cells.
European journal of biochemistry / FEBS 1999;261(2):481-91.
1999: Gervois P; Chopin-Delannoy S; Fadel A; Dubois G; Kosykh V; Fruchart J C; Najïb J; Laudet V; Staels B
Fibrates increase human REV-ERBalpha expression in liver via a novel peroxisome proliferator-activated receptor response element.
Molecular endocrinology (Baltimore, Md.) 1999;13(3):400-9.
1999: Andersson Y; Majd Z; Lefebvre A M; Martin G; Sechkin A V; Kosykh V; Fruchart J C; Najib J; Staels B
Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(1):115-21.
1999: Madsen L; Frøyland L; Kryvi H; Auwerx J; Staels B; Berge R K
The mitochondrion is the principal target for nutritional and pharmacological control of plasma triglyceride.
Lipids 1999;34 Suppl():S167.
1998: Mamontova A; Séguret-Macé S; Esposito B; Chaniale C; Bouly M; Delhaye-Bouchaud N; Luc G; Staels B; Duverger N; Mariani J; Tedgui A
Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha.
Circulation 1998;98(24):2738-43.
1998: Vu-Dac N; Chopin-Delannoy S; Gervois P; Bonnelye E; Martin G; Fruchart J C; Laudet V; Staels B
The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates.
The Journal of biological chemistry 1998;273(40):25713-20.
1998: Chinetti G; Griglio S; Antonucci M; Torra I P; Delerive P; Majd Z; Fruchart J C; Chapman J; Najib J; Staels B
Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages.
The Journal of biological chemistry 1998;273(40):25573-80.
1998: Edgar A D; Tomkiewicz C; Costet P; Legendre C; Aggerbeck M; Bouguet J; Staels B; Guyomard C; Pineau T; Barouki R
Fenofibrate modifies transaminase gene expression via a peroxisome proliferator activated receptor alpha-dependent pathway.
Toxicology letters 1998;98(1-2):13-23.
1998: Vu-Dac N; Gervois P; Torra I P; Fruchart J C; Kosykh V; Kooistra T; Princen H M; Dallongeville J; Staels B
Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids.
The Journal of clinical investigation 1998;102(3):625-32.
1998: Staels B; Koenig W; Habib A; Merval R; Lebret M; Torra I P; Delerive P; Fadel A; Chinetti G; Fruchart J C; Najib J; Maclouf J; Tedgui A
Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators.
Nature 1998;393(6687):790-3.
1998: Martin G; Schoonjans K; Staels B; Auwerx J
PPARgamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes.
Atherosclerosis 1998;137 Suppl():S75-80.
1998: Staels B; Auwerx J
Regulation of apo A-I gene expression by fibrates.
Atherosclerosis 1998;137 Suppl():S19-23.
1997: Martin G; Schoonjans K; Lefebvre A M; Staels B; Auwerx J
Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators.
The Journal of biological chemistry 1997;272(45):28210-7.
1997: Peters J M; Hennuyer N; Staels B; Fruchart J C; Fievet C; Gonzalez F J; Auwerx J
Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice.
The Journal of biological chemistry 1997;272(43):27307-12.
1997: Lefebvre A M; Peinado-Onsurbe J; Leitersdorf I; Briggs M R; Paterniti J R; Fruchart J C; Fievet C; Auwerx J; Staels B
Regulation of lipoprotein metabolism by thiazolidinediones occurs through a distinct but complementary mechanism relative to fibrates.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(9):1756-64.
1997: Frøyland L; Madsen L; Vaagenes H; Totland G K; Auwerx J; Kryvi H; Staels B; Berge R K
Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism.
Journal of lipid research 1997;38(9):1851-8.
1997: Vu-Dac N; Gervois P; Grötzinger T; De Vos P; Schoonjans K; Fruchart J C; Auwerx J; Mariani J; Tedgui A; Staels B
Transcriptional regulation of apolipoprotein A-I gene expression by the nuclear receptor RORalpha.
The Journal of biological chemistry 1997;272(36):22401-4.
1997: Auboeuf D; Rieusset J; Fajas L; Vallier P; Frering V; Riou J P; Staels B; Auwerx J; Laville M; Vidal H
Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients.
Diabetes 1997;46(8):1319-27.
1997: Fajas L; Auboeuf D; Raspé E; Schoonjans K; Lefebvre A M; Saladin R; Najib J; Laville M; Fruchart J C; Deeb S; Vidal-Puig A; Flier J; Briggs M R; Staels B; Vidal H; Auwerx J
The organization, promoter analysis, and expression of the human PPARgamma gene.
The Journal of biological chemistry 1997;272(30):18779-89.
1997: Schoonjans K; Martin G; Staels B; Auwerx J
Peroxisome proliferator-activated receptors, orphans with ligands and functions.
Current opinion in lipidology 1997;8(3):159-66.
1997: Staels B; Schoonjans K; Fruchart J C; Auwerx J
The effects of fibrates and thiazolidinediones on plasma triglyceride metabolism are mediated by distinct peroxisome proliferator activated receptors (PPARs).
Biochimie 1997;79(2-3):95-9.
1996: Schoonjans K; Peinado-Onsurbe J; Lefebvre A M; Heyman R A; Briggs M; Deeb S; Staels B; Auwerx J
PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.
The EMBO journal 1996;15(19):5336-48.
1996: Bossu J P; Chartier F L; Fruchart J C; Auwerx J; Staels B; Laine B
Two regulatory elements of similar structure and placed in tandem account for the repressive activity of the first intron of the human apolipoprotein A-II gene.
The Biochemical journal 1996;318 ( Pt 2)():547-53.
1996: De Vos P; Lefebvre A M; Miller S G; Guerre-Millo M; Wong K; Saladin R; Hamann L G; Staels B; Briggs M R; Auwerx J
Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma.
The Journal of clinical investigation 1996;98(4):1004-9.
1996: Auwerx J; Schoonjans K; Fruchart J C; Staels B
Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR.
Atherosclerosis 1996;124 Suppl():S29-37.
1996: Vidal H; Auboeuf D; De Vos P; Staels B; Riou J P; Auwerx J; Laville M
The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue.
The Journal of clinical investigation 1996;98(2):251-5.
1996: Saladin R; Vu-Dac N; Fruchart J C; Auwerx J; Staels B
Transcriptional induction of rat liver apolipoprotein A-I gene expression by glucocorticoids requires the glucocorticoid receptor and a labile cell-specific protein.
European journal of biochemistry / FEBS 1996;239(2):451-9.
1996: Vu-Dac N; Schoonjans K; Kosykh V; Dallongeville J; Heyman R A; Staels B; Auwerx J
Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor.
Molecular and cellular biology 1996;16(7):3350-60.
1996: Staels B; Martin G; Martinez M; Albert C; Peinado-Onsurbe J; Saladin R; Hum D W; Reina M; Vilaro S; Auwerx J
Expression and regulation of the lipoprotein lipase gene in human adrenal cortex.
The Journal of biological chemistry 1996;271(29):17425-32.
1996: Berthou L; Duverger N; Emmanuel F; Langouët S; Auwerx J; Guillouzo A; Fruchart J C; Rubin E; Denèfle P; Staels B; Branellec D
Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice.
The Journal of clinical investigation 1996;97(11):2408-16.
1996: Casaroli-Marano R P; Peinado-Onsurbe J; Reina M; Staels B; Auwerx J; Vilaró S
Lipoprotein lipase in highly vascularized structures of the eye.
Journal of lipid research 1996;37(5):1037-44.
1996: Miller S G; De Vos P; Guerre-Millo M; Wong K; Hermann T; Staels B; Briggs M R; Auwerx J
The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5507-11.
1995: Saladin R; De Vos P; Guerre-Millo M; Leturque A; Girard J; Staels B; Auwerx J
Transient increase in obese gene expression after food intake or insulin administration.
Nature 1995;377(6549):527-9.
1995: Schoonjans K; Watanabe M; Suzuki H; Mahfoudi A; Krey G; Wahli W; Grimaldi P; Staels B; Yamamoto T; Auwerx J
Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter.
The Journal of biological chemistry 1995;270(33):19269-76.
1995: Vu-Dac N; Schoonjans K; Kosykh V; Dallongeville J; Fruchart J C; Staels B; Auwerx J
Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.
The Journal of clinical investigation 1995;96(2):741-50.
1995: Berthou L; Saladin R; Yaqoob P; Branellec D; Calder P; Fruchart J C; Denèfle P; Auwerx J; Staels B
Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids.
European journal of biochemistry / FEBS 1995;232(1):179-87.
1995: De Vos P; Saladin R; Auwerx J; Staels B
Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake.
The Journal of biological chemistry 1995;270(27):15958-61.
1995: Mehlum A; Staels B; Duverger N; Tailleux A; Castro G; Fievet C; Luc G; Fruchart J C; Olivecrona G; Skretting G
Tissue-specific expression of the human gene for lecithin: cholesterol acyltransferase in transgenic mice alters blood lipids, lipoproteins and lipases towards a less atherogenic profile.
European journal of biochemistry / FEBS 1995;230(2):567-75.
1995: Staels B; Vu-Dac N; Kosykh V A; Saladin R; Fruchart J C; Dallongeville J; Auwerx J
Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.
The Journal of clinical investigation 1995;95(2):705-12.
1994: Vu-Dac N; Schoonjans K; Laine B; Fruchart J C; Auwerx J; Staels B
Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.
The Journal of biological chemistry 1994;269(49):31012-8.
1994: Berthou L; Staels B; Saldicco I; Berthelot K; Casey J; Fruchart J C; Denèfle P; Branellec D
Opposite in vitro and in vivo regulation of hepatic apolipoprotein A-I gene expression by retinoic acid. Absence of effects on apolipoprotein A-II gene expression.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(10):1657-64.
1993: Schoonjans K; Staels B; Grimaldi P; Auwerx J
Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation.
European journal of biochemistry / FEBS 1993;216(2):615-22.
1993: Schoonjans K; Staels B; Devos P; Szpirer J; Szpirer C; Deeb S; Verhoeven G; Auwerx J
Developmental extinction of liver lipoprotein lipase mRNA expression might be regulated by an NF-1-like site.
FEBS letters 1993;329(1-2):89-95.
1993: Peinado-Onsurbe J; Staels B; Vanderschueren D; Bouillon R; Auwerx J
Effects of sex steroids on hepatic and lipoprotein lipase activity and mRNA in the rat.
Hormone research 1993;40(5-6):184-8.
1992: Jansen H; van Tol A; Auwerx J; Skretting G; Staels B
Opposite regulation of hepatic lipase and lecithin: cholesterol acyltransferase by glucocorticoids in rats.
Biochimica et biophysica acta 1992;1128(2-3):181-5.
1992: Peinado-Onsurbe J; Staels B; Deeb S; Auwerx J
Lipoprotein lipase expression in undifferentiated hepatoma cells is regulated by progesterone and protein kinase A.
Biochemistry 1992;31(41):10121-8.
1992: Staels B; Auwerx J
Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and alpha-fetoprotein as models.
Development (Cambridge, England) 1992;115(4):1035-43.
1992: Peinado-Onsurbe J; Staels B; Deeb S; Ramirez I; Llobera M; Auwerx J
Neonatal extinction of liver lipoprotein lipase expression.
Biochimica et biophysica acta 1992;1131(3):281-6.
1992: Staels B; van Tol A; Skretting G; Auwerx J
Lecithin:cholesterol acyltransferase gene expression is regulated in a tissue-selective manner by fibrates.
Journal of lipid research 1992;33(5):727-35.
1992: Staels B; van Tol A; Andreu T; Auwerx J
Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(3):286-94.
1992: Staels B; Peinado-Onsurbe J; Auwerx J
Down-regulation of hepatic lipase gene expression and activity by fenofibrate.
Biochimica et biophysica acta 1992;1123(2):227-30.
1991: Staels B; van Tol A; Jansen H; Auwerx J
The effects of probucol on lipoprotein metabolism in the rat.
Biochimica et biophysica acta 1991;1085(1):131-5.
1991: Staels B; van Tol A; Chan L; Verhoeven G; Auwerx J
Variable effects of different corticosteroids on plasma lipids, apolipoproteins, and hepatic apolipoprotein mRNA levels in rats.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(3):760-9.
1990: Staels B; Van Tol A; Chan L; Will H; Verhoeven G; Auwerx J
Alterations in thyroid status modulate apolipoprotein, hepatic triglyceride lipase, and low density lipoprotein receptor in rats.
Endocrinology 1990;127(3):1144-52.
1990: Staels B; Jansen H; van Tol A; Stahnke G; Will H; Verhoeven G; Auwerx J
Development, food intake, and ethinylestradiol influence hepatic triglyceride lipase and LDL-receptor mRNA levels in rats.
Journal of lipid research 1990;31(7):1211-8.
1990: Staels B; van Tol A; Verhoeven G; Auwerx J
Apolipoprotein A-IV messenger ribonucleic acid abundance is regulated in a tissue-specific manner.
Endocrinology 1990;126(4):2153-63.
1989: Staels B; Auwerx J; Chan L; van Tol A; Rosseneu M; Verhoeven G
Influence of development, estrogens, and food intake on apolipoprotein A-I, A-II, and E mRNA in rat liver and intestine.
Journal of lipid research 1989;30(8):1137-45.

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