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Robert Stafford

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Chemicals & Drugs

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Botulism

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Publications

TOP 3
Harry B Hines; Alexander D Kim; Robert G Stafford; Shirin S Badie; Ernst E Brueggeman; David Newman; James J Schmidt
Use of a recombinant fluorescent substrate with cleavage sites for all botulinum neurotoxins in high-throughput screening of natural product extracts for inhibitors of serotypes A, B, and E.
James C Burnett; Gordon Ruthel; Christian Stegmann; Rekha G Panchal; Tam L Nguyen; Ann R Hermone; Robert G Stafford; Douglas J Lane; Tara A Kenny; Connor F McGrath; Peter Wipf; Andrea M Stahl; James J Schmidt; Rick Gussio; Axel T Brunger; Sina Bavari
Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
James J Schmidt; Robert G Stafford
Botulinum neurotoxin serotype F: identification of substrate recognition requirements and development of inhibitors with low nanomolar affinity.

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All Publications

2008: Harry B Hines; Alexander D Kim; Robert G Stafford; Shirin S Badie; Ernst E Brueggeman; David Newman; James J Schmidt
Use of a recombinant fluorescent substrate with cleavage sites for all botulinum neurotoxins in high-throughput screening of natural product extracts for inhibitors of serotypes A, B, and E.
Applied and environmental microbiology 2008;74(3):653-9.
2007: James C Burnett; Gordon Ruthel; Christian Stegmann; Rekha G Panchal; Tam L Nguyen; Ann R Hermone; Robert G Stafford; Douglas J Lane; Tara A Kenny; Connor F McGrath; Peter Wipf; Andrea M Stahl; James J Schmidt; Rick Gussio; Axel T Brunger; Sina Bavari
Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
The Journal of biological chemistry 2007;282(7):5004-14.
2005: James J Schmidt; Robert G Stafford
Botulinum neurotoxin serotype F: identification of substrate recognition requirements and development of inhibitors with low nanomolar affinity.
Biochemistry 2005;44(10):4067-73.
2003: James C Burnett; James J Schmidt; Robert G Stafford; Rekha G Panchal; Tam L Nguyen; Ann R Hermone; Jonathan L Vennerstrom; Connor F McGrath; Douglas J Lane; Edward A Sausville; Daniel W Zaharevitz; Rick Gussio; Sina Bavari
Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.
Biochemical and biophysical research communications 2003;310(1):84-93.
2003: James J Schmidt; Robert G Stafford
Fluorigenic substrates for the protease activities of botulinum neurotoxins, serotypes A, B, and F.
Applied and environmental microbiology 2003;69(1):297-303.
2002: James J Schmidt; Robert G Stafford
A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity.
FEBS letters 2002;532(3):423-6.
2001: James J Schmidt; Robert G Stafford; Charles B Millard
High-throughput assays for botulinum neurotoxin proteolytic activity: serotypes A, B, D, and F.
Analytical biochemistry 2001;296(1):130-7.
1998: James J Schmidt; Robert G Stafford; K A Bostian
Type A botulinum neurotoxin proteolytic activity: development of competitive inhibitors and implications for substrate specificity at the S1' binding subsite.
FEBS letters 1998;435(1):61-4.