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George Stamatoyannopoulos

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Chemicals & Drugs

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Yeast Artificial Chromosomes

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Acute Erythroblastic Leukemia

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Jeffery R Hughey; Dimitra M Lotakis; Donald Mastropaolo; Manolis Michalodimitrakis; Patrick A Navas; Peristera Paschou; Petros Drineas; John A Stamatoyannopoulos; George Stamatoyannopoulos
A European population in Minoan Bronze Age Crete.
Mingdong Liu; George Stamatoyannopoulos; John A Stamatoyannopoulos; Michael O Dorschner; Richard Humbert; Chang Long Li; David W Emery
Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sites.
Douglas R Higgs; James Douglas Engel; George Stamatoyannopoulos
Thalassaemia.

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2013: Jeffery R Hughey; Dimitra M Lotakis; Donald Mastropaolo; Manolis Michalodimitrakis; Patrick A Navas; Peristera Paschou; Petros Drineas; John A Stamatoyannopoulos; George Stamatoyannopoulos
A European population in Minoan Bronze Age Crete.
Nature communications 2013;4():1861.
2012: Mingdong Liu; George Stamatoyannopoulos; John A Stamatoyannopoulos; Michael O Dorschner; Richard Humbert; Chang Long Li; David W Emery
Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sites.
Human gene therapy 2012;23(2):231-7.
2012: Douglas R Higgs; James Douglas Engel; George Stamatoyannopoulos
Thalassaemia.
Lancet 2012;379(9813):373-83.
2010: Evangelia Yannaki; George Stamatoyannopoulos
Hematopoietic stem cell mobilization strategies for gene therapy of beta thalassemia and sickle cell disease.
Annals of the New York Academy of Sciences 2010;1202():59-63.
2010: George Stamatoyannopoulos
The birth of the American Society of Gene Therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(3):462-5.
2010: Pandelis Spyrou; Marios Phylactides; Carsten W Lederer; Lucas Kithreotis; Andriani Kirri; Soteroulla Christou; Elena Kkolou; Emmanuel Kanavakis; Nicholas P Anagnou; George Stamatoyannopoulos; Marina Kleanthous
Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model.
Blood cells, molecules & diseases 2010;44(2):100-6.
2010: Evangelia Yannaki; David W Emery; George Stamatoyannopoulos
Gene therapy for β-thalassaemia: the continuing challenge.
Expert reviews in molecular medicine 2010;12():e31.
2009: Xiangdong Fang; Wenxuan Yin; Ping Xiang; Hemei Han; George Stamatoyannopoulos; Qiliang Li
The higher structure of chromatin in the LCR of the beta-globin locus changes during development.
Journal of molecular biology 2009;394(2):197-208.
2009: Chang Long Li; Ding Xiong; George Stamatoyannopoulos; David W Emery
Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(4):716-24.
2008: Pavel Sova; Hongjie Wang; Karol Bomsztyk; George Stamatoyannopoulos; André Lieber
Role of chromatin structure in integration of helper-dependent adenoviral vectors containing the beta-globin locus control region.
Human gene therapy 2008;19(2):153-66.
2007: Wenxuan Yin; Gráinne Barkess; Xiangdong Fang; Ping Xiang; Hua Cao; George Stamatoyannopoulos; Qiliang Li
Histone acetylation at the human beta-globin locus changes with developmental age.
Blood 2007;110(12):4101-7.
2007: Mei Zhan; Chris P Miller; Thalia Papayannopoulou; George Stamatoyannopoulos; Chao-Zhong Song
MicroRNA expression dynamics during murine and human erythroid differentiation.
Experimental hematology 2007;35(7):1015-25.
2007: Angela Di Baldassarre; Mariacristina Di Rico; Antonella Di Noia; Tiziana Bonfini; Antonio Iacone; Marco Marchisio; Sebastiano Miscia; Elena Alfani; Anna Rita Migliaccio; George Stamatoyannopoulos; Giovanni Migliaccio
Protein kinase Calpha is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the (A)gamma globin-promoter in cellular models of hemoglobin switching.
Journal of cellular biochemistry 2007;101(2):411-24.
2007: Mari Aker; Julie Tubb; Amy C Groth; Anatoly A Bukovsky; Adam C Bell; Gary Felsenfeld; Hans-Peter Kiem; George Stamatoyannopoulos; David W Emery
Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects.
Human gene therapy 2007;18(4):333-43.
2007: Jie Hong Hu; Patrick A Navas; Hua Cao; George Stamatoyannopoulos; Chao-Zhong Song
Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation.
Journal of molecular biology 2007;366(4):1064-73.
2007: David W Emery; Georgios Gavriilidis; Haruhiko Asano; George Stamatoyannopoulos
The transcription factor KLF11 can induce gamma-globin gene expression in the setting of in vivo adult erythropoiesis.
Journal of cellular biochemistry 2007;100(4):1045-55.
2007: Ivan Olave; Catalin E Doneanu; Xiangdong Fang; George Stamatoyannopoulos; Qiliang Li
Purification and identification of proteins that bind to the hereditary persistence of fetal hemoglobin -198 mutation in the gamma-globin gene promoter.
The Journal of biological chemistry 2007;282(2):853-62.
2007: Xiangdong Fang; Ping Xiang; Wenxuan Yin; George Stamatoyannopoulos; Qiliang Li
Cooperativeness of the higher chromatin structure of the beta-globin locus revealed by the deletion mutations of DNase I hypersensitive site 3 of the LCR.
Journal of molecular biology 2007;365(1):31-7.
2006: Hua Cao; George Stamatoyannopoulos
Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin.
American journal of hematology 2006;81(12):981-3.
2006: Mari Aker; Julie Tubb; Daniel G Miller; George Stamatoyannopoulos; David W Emery
Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(2):226-35.
2006: Tamon Nishino; Hua Cao; George Stamatoyannopoulos; David W Emery
Effects of human gamma-globin in murine beta-thalassaemia.
British journal of haematology 2006;134(1):100-8.
2006: Man Yu; Hemei Han; Ping Xiang; Qiliang Li; George Stamatoyannopoulos
Autonomous silencing as well as competition controls gamma-globin gene expression during development.
Molecular and cellular biology 2006;26(13):4775-81.
2006: Patrick A Navas; Qiliang Li; Kenneth R Peterson; George Stamatoyannopoulos
Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.
Experimental biology and medicine (Maywood, N.J.) 2006;231(3):328-34.
2006: Qiliang Li; Xiangdong Fang; Ivan Olave; Hemei Han; Man Yu; Ping Xiang; George Stamatoyannopoulos
Transcriptional potential of the gamma-globin gene is dependent on the CACCC box in a developmental stage-specific manner.
Nucleic acids research 2006;34(14):3909-16.
2005: Hua Cao; Manfred Jung; George Stamatoyannopoulos
Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce gamma gene expression in vivo.
Experimental hematology 2005;33(12):1443-9.
2005: Man Yu; Qiliang Li; George Stamatoyannopoulos
Investigations of the induction of the goat beta(C) globin gene by erythropoietin: studies in transgenic mice.
Blood cells, molecules & diseases 2005;35(3):332-8.
2005: Ping Xiang; Hemei Han; Gráinne Barkess; Ivan Olave; Xiangdong Fang; Wenxuan Yin; George Stamatoyannopoulos; Qiliang Li
Juxtaposition of the HPFH2 enhancer is not sufficient to reactivate the gamma-globin gene in adult erythropoiesis.
Human molecular genetics 2005;14(20):3047-56.
2005: Susanna Harju; Patrick A Navas; George Stamatoyannopoulos; Kenneth R Peterson
Genome architecture of the human beta-globin locus affects developmental regulation of gene expression.
Molecular and cellular biology 2005;25(20):8765-78.
2005: Xiangdong Fang; Jin Sun; Ping Xiang; Man Yu; Patrick A Navas; Kenneth R Peterson; George Stamatoyannopoulos; Qiliang Li
Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.
Molecular and cellular biology 2005;25(16):7033-41.
2005: David W Emery; Julie Tubb; Yumiko Nishino; Tamon Nishino; Kevin Otto; George Stamatoyannopoulos; C Anthony Blau
Selection with a regulated cell growth switch increases the likelihood of expression for a linked gamma-globin gene.
Blood cells, molecules & diseases 2005;34(3):235-47.
2005: Qiliang Li; David W Emery; Hemei Han; Jin Sun; Man Yu; George Stamatoyannopoulos
Differences of globin transgene expression in stably transfected cell lines and transgenic mice.
Blood 2005;105(8):3346-52.
2005: George Stamatoyannopoulos
Control of globin gene expression during development and erythroid differentiation.
Experimental hematology 2005;33(3):259-71.
2005: Rona S Weinberg; Xinjun Ji; Millicent Sutton; Susan P Perrine; Yelena Galperin; Qiliang Li; Stephen A Liebhaber; George Stamatoyannopoulos; George F Atweh
Butyrate increases the efficiency of translation of gamma-globin mRNA.
Blood 2005;105(4):1807-9.
2005: Ayako Mitsuma; Haruhiko Asano; Tomohiro Kinoshita; Takashi Murate; Hidehiko Saito; George Stamatoyannopoulos; Tomoki Naoe
Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells.
Biochimica et biophysica acta 2005;1727(2):125-33.
2005: Chao-Zhong Song; Georgios Gavriilidis; Haruhiko Asano; George Stamatoyannopoulos
Functional study of transcription factor KLF11 by targeted gene inactivation.
Blood cells, molecules & diseases 2005;34(1):53-9.
2004: Haruhiko Asano; Takashi Murate; Tomoki Naoe; Hidehiko Saito; George Stamatoyannopoulos
Molecular cloning and characterization of ZFF29: a protein containing a unique Cys2His2 zinc-finger motif.
The Biochemical journal 2004;384(Pt 3):647-53.
2004: Qiliang Li; Hemei Han; Xin Ye; Mary Stafford; Gráinne Barkess; George Stamatoyannopoulos
Transcriptional potentials of the beta-like globin genes at different developmental stages in transgenic mice and hemoglobin switching.
Blood cells, molecules & diseases 2004;33(3):318-25.
2004: Qiliang Li; Xiangdong Fang; Hemei Han; George Stamatoyannopoulos
The minimal promoter plays a major role in silencing of the galago gamma-globin gene in adult erythropoiesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):8096-101.
2004: Kenneth R Peterson; Halyna Fedosyuk; Lesya Zelenchuk; Betty Nakamoto; Evangelia Yannaki; George Stamatoyannopoulos; Steven Ciciotte; Luanne L Peters; Linda Maree SCOTT; Thalia Papayannopoulou
Transgenic Cre expression mice for generation of erythroid-specific gene alterations.
Genesis (New York, N.Y. : 2000) 2004;39(1):1-9.
2004: Xiangdong Fang; Hemei Han; George Stamatoyannopoulos; Qiliang Li
Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression.
The Journal of biological chemistry 2004;279(7):5444-9.
2004: Hua Cao; George Stamatoyannopoulos; Manfred Jung
Induction of human gamma globin gene expression by histone deacetylase inhibitors.
Blood 2004;103(2):701-9.
2003: Patrick A Navas; Richard A Swank; Man Yu; Kenneth R Peterson; George Stamatoyannopoulos
Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.
Human molecular genetics 2003;12(22):2941-8.
2003: Yangchao Chen; George Stamatoyannopoulos; Chao-Zhong Song
Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro.
Cancer research 2003;63(16):4801-4.
2003: Chao-Zhong Song; Kimberly Keller; Yangchao Chen; George Stamatoyannopoulos
Functional interplay between CBP and PCAF in acetylation and regulation of transcription factor KLF13 activity.
Journal of molecular biology 2003;329(2):207-15.
2003: Richard A Swank; Eva Skarpidi; Thalia Papayannopoulou; George Stamatoyannopoulos
The histone deacetylase inhibitor, trichostatin A, reactivates the developmentally silenced gamma globin expression in somatic cell hybrids and induces gamma gene expression in adult BFUe cultures.
Blood cells, molecules & diseases 2003;30(3):254-7.
2003: Eva Skarpidi; Hua Cao; Birgit Heltweg; Brian F White; Ronald L Marhenke; Manfred Jung; George Stamatoyannopoulos
Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression.
Experimental hematology 2003;31(3):197-203.
2002: Qiliang Li; Kenneth R Peterson; Xiangdong Fang; George Stamatoyannopoulos
Locus control regions.
Blood 2002;100(9):3077-86.
2002: Channing Yu; Kathy K Niakan; Mark Matsushita; George Stamatoyannopoulos; Stuart H Orkin; Wendy H Raskind
X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction.
Blood 2002;100(6):2040-5.
2002: David W Emery; Evangelia Yannaki; Julie Tubb; Tamon Nishino; Qiliang Li; George Stamatoyannopoulos
Development of virus vectors for gene therapy of beta chain hemoglobinopathies: flanking with a chromatin insulator reduces gamma-globin gene silencing in vivo.
Blood 2002;100(6):2012-9.
2002: Chao-Zhong Song; Kimberly Keller; Yangchao Chen; Ken Murata; George Stamatoyannopoulos
Transcription coactivator CBP has direct DNA binding activity and stimulates transcription factor DNA binding through small domains.
Biochemical and biophysical research communications 2002;296(1):118-24.
2002: Effie Liakopoulou; Qiliang Li; George Stamatoyannopoulos
Induction of fetal hemoglobin by propionic and butyric acid derivatives: correlations between chemical structure and potency of Hb F induction.
Blood cells, molecules & diseases 2002;29(1):48-56.
2002: Qiliang Li; Miaohua Zhang; Hemei Han; Alex Rohde; George Stamatoyannopoulos
Evidence that DNase I hypersensitive site 5 of the human beta-globin locus control region functions as a chromosomal insulator in transgenic mice.
Nucleic acids research 2002;30(11):2484-91.
2002: Evangelia Yannaki; Julie Tubb; Mari Aker; George Stamatoyannopoulos; David W Emery
Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(5 Pt 1):589-98.
2002: Zhi-Jun Duan; Xiangdong Fang; Alex Rohde; Hemei Han; George Stamatoyannopoulos; Qiliang Li
Developmental specificity of recruitment of TBP to the TATA box of the human gamma-globin gene.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5509-14.
2002: Patrick A Navas; Qiliang Li; Kenneth R Peterson; Richard A Swank; Alex Rohde; Julianne Roy; George Stamatoyannopoulos
Activation of the beta-like globin genes in transgenic mice is dependent on the presence of the beta-locus control region.
Human molecular genetics 2002;11(8):893-903.
2002: David W Emery; Tamon Nishino; Ken Murata; Michalis Fragkos; George Stamatoyannopoulos
Hematopoietic stem cell gene therapy.
International journal of hematology 2002;75(3):228-36.
2002: Chao-Zhong Song; Kimberly Keller; Ken Murata; Haruhiko Asano; George Stamatoyannopoulos
Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2.
The Journal of biological chemistry 2002;277(9):7029-36.
2002: Dmitry M Shayakhmetov; Cheryl A Carlson; Hartmut Stecher; Qiliang Li; George Stamatoyannopoulos; André Lieber
A high-capacity, capsid-modified hybrid adenovirus/adeno-associated virus vector for stable transduction of human hematopoietic cells.
Journal of virology 2002;76(3):1135-43.
2001: Michael McArthur; S Gerum; George Stamatoyannopoulos
Quantification of DNaseI-sensitivity by real-time PCR: quantitative analysis of DNaseI-hypersensitivity of the mouse beta-globin LCR.
Journal of molecular biology 2001;313(1):27-34.
2001: Patrick A Navas; Kenneth R Peterson; Qiliang Li; Michael McArthur; George Stamatoyannopoulos
The 5'HS4 core element of the human beta-globin locus control region is required for high-level globin gene expression in definitive but not in primitive erythropoiesis.
Journal of molecular biology 2001;312(1):17-26.
2001: Hartmut Stecher; Dmitry M Shayakhmetov; George Stamatoyannopoulos; André Lieber
A capsid-modified adenovirus vector devoid of all viral genes: assessment of transduction and toxicity in human hematopoietic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2001;4(1):36-44.
2001: Zhijun Duan; George Stamatoyannopoulos; Qiliang Li
Role of NF-Y in in vivo regulation of the gamma-globin gene.
Molecular and cellular biology 2001;21(9):3083-95.
2001: Qiliang Li; Z J Duan; George Stamatoyannopoulos
Analysis of the mechanism of action of non-deletion hereditary persistence of fetal hemoglobin mutants in transgenic mice.
The EMBO journal 2001;20(1-2):157-64.
2001: Y Yang; Z Duan; Eva Skarpidi; Qiliang Li; Thalia Papayannopoulou; George Stamatoyannopoulos
Cloning and characterization of a potential transcriptional activator of human gamma-globin genes.
Blood cells, molecules & diseases 2001;27(1):1-15.
2000: David W Emery; Evangelia Yannaki; Julie Tubb; George Stamatoyannopoulos
A chromatin insulator protects retrovirus vectors from chromosomal position effects.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9150-5.
2000: Eva Skarpidi; George Vassilopoulos; Qiliang Li; George Stamatoyannopoulos
Novel in vitro assay for the detection of pharmacologic inducers of fetal hemoglobin.
Blood 2000;96(1):321-6.
2000: Haruhiko Asano; X S Li; George Stamatoyannopoulos
FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes.
Blood 2000;95(11):3578-84.
2000: Wendy H Raskind; Kathy K Niakan; J Wolff; Mark Matsushita; T Vaughan; George Stamatoyannopoulos; C Watanabe; J Rios; Hans D Ochs
Mapping of a syndrome of X-linked thrombocytopenia with Thalassemia to band Xp11-12: further evidence of genetic heterogeneity of X-linked thrombocytopenia.
Blood 2000;95(7):2262-8.
2000: Dmitry M Shayakhmetov; Thalia Papayannopoulou; George Stamatoyannopoulos; André Lieber
Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector.
Journal of virology 2000;74(6):2567-83.
2000: Marie-José Blouin; Hugues Beauchemin; A Wright; M De Paepe; M Sorette; Anne-Marie Bleau; Betty Nakamoto; C N Ou; George Stamatoyannopoulos; Marie Trudel
Genetic correction of sickle cell disease: insights using transgenic mouse models.
Nature medicine 2000;6(2):177-82.
1999: Haruhiko Asano; X S Li; George Stamatoyannopoulos
FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes.
Molecular and cellular biology 1999;19(5):3571-9.
1999: David W Emery; George Stamatoyannopoulos
Stem cell gene therapy for the beta-chain hemoglobinopathies. Problems and progress.
Annals of the New York Academy of Sciences 1999;872():94-107; discussion 107-8.
1999: David W Emery; F Morrish; Qiliang Li; George Stamatoyannopoulos
Analysis of gamma-globin expression cassettes in retrovirus vectors.
Human gene therapy 1999;10(6):877-88.
1999: Qiliang Li; David W Emery; M Fernandez; Hemei Han; George Stamatoyannopoulos
Development of viral vectors for gene therapy of beta-chain hemoglobinopathies: optimization of a gamma-globin gene expression cassette.
Blood 1999;93(7):2208-16.
1999: George F Atweh; Millicent Sutton; I Nassif; V Boosalis; George J Dover; Sylvan Wallenstein; E Wright; Lillian McMahon; George Stamatoyannopoulos; Douglas V Faller; Susan P Perrine
Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.
Blood 1999;93(6):1790-7.
1999: George Vassilopoulos; Patrick A Navas; Eva Skarpidi; Kenneth R Peterson; C H Lowrey; Thalia Papayannopoulou; George Stamatoyannopoulos
Correct function of the locus control region may require passage through a nonerythroid cellular environment.
Blood 1999;93(2):703-12.
1998: Kenneth R Peterson; Patrick A Navas; Qiliang Li; George Stamatoyannopoulos
LCR-dependent gene expression in beta-globin YAC transgenics: detailed structural studies validate functional analysis even in the presence of fragmented YACs.
Human molecular genetics 1998;7(13):2079-88.
1998: Eva Skarpidi; George Vassilopoulos; George Stamatoyannopoulos; Qiliang Li
Comparison of expression of human globin genes transferred into mouse erythroleukemia cells and in transgenic mice.
Blood 1998;92(9):3416-21.
1998: David W Emery; H Chen; Qiliang Li; George Stamatoyannopoulos
Development of a condensed locus control region cassette and testing in retrovirus vectors for A gamma-globin.
Blood cells, molecules & diseases 1998;24(3):322-39.
1998: Qiliang Li; C A Blau; CH Clegg; Alex Rohde; George Stamatoyannopoulos
Multiple epsilon-promoter elements participate in the developmental control of epsilon-globin genes in transgenic mice.
The Journal of biological chemistry 1998;273(28):17361-7.
1998: Patrick A Navas; Kenneth R Peterson; Qiliang Li; Eva Skarpidi; Alex Rohde; S E Shaw; CH Clegg; Haruhiko Asano; George Stamatoyannopoulos
Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion.
Molecular and cellular biology 1998;18(7):4188-96.
1998: Kenneth R Peterson; Patrick A Navas; George Stamatoyannopoulos
beta-YAC transgenic mice for studying LCR function.
Annals of the New York Academy of Sciences 1998;850():28-37.
1998: Qiliang Li; Kenneth R Peterson; George Stamatoyannopoulos
Developmental control of epsilon- and gamma-globin genes.
Annals of the New York Academy of Sciences 1998;850():10-7.
1998: Richard A Swank; George Stamatoyannopoulos
Fetal gene reactivation.
Current opinion in genetics & development 1998;8(3):366-70.
1998: Haruhiko Asano; George Stamatoyannopoulos
Activation of beta-globin promoter by erythroid Krüppel-like factor.
Molecular and cellular biology 1998;18(1):102-9.
1997: H Chen; C H Lowrey; George Stamatoyannopoulos
Analysis of enhancer function of the HS-40 core sequence of the human alpha-globin cluster.
Nucleic acids research 1997;25(14):2917-22.
1997: Qiliang Li; CH Clegg; K Peterson; S Shaw; N Raich; George Stamatoyannopoulos
Binary transgenic mouse model for studying the trans control of globin gene switching: evidence that GATA-1 is an in vivo repressor of human epsilon gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2444-8.
1997: Kenneth R Peterson; CH Clegg; Qiliang Li; George Stamatoyannopoulos
Production of transgenic mice with yeast artificial chromosomes.
Trends in genetics : TIG 1997;13(2):61-6.
1996: Kenneth R Peterson; CH Clegg; Patrick A Navas; E J Norton; T G Kimbrough; George Stamatoyannopoulos
Effect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6605-9.
1996: Y Yang; Kenneth R Peterson; George Stamatoyannopoulos; Thalia Papayannopoulou
Human CD34+ cell EST database: single-pass sequencing of 402 clones from a directional cDNA library.
Experimental hematology 1996;24(5):605-12.
1996: C Anthony Blau; George Stamatoyannopoulos
Preemptive therapy for genetic disease.
Nature medicine 1996;2(2):161-2.
1995: E Liakopoulou; C Anthony Blau; Qiliang Li; B Josephson; J A Wolf; B Fournarakis; V Raisys; George J Dover; Thalia Papayannopoulou; George Stamatoyannopoulos
Stimulation of fetal hemoglobin production by short chain fatty acids.
Blood 1995;86(8):3227-35.
1995: Patrick A Navas; B Josephson; T Furukawa; George Stamatoyannopoulos; Qiliang Li
The position of integration affects expression of the A gamma-globin-encoding gene linked to HS3 in transgenic mice.
Gene 1995;160(2):165-71.
1995: Kenneth R Peterson; Q L Li; CH Clegg; T Furukawa; Patrick A Navas; E J Norton; T G Kimbrough; George Stamatoyannopoulos
Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5655-9.
1995: Daniel E Sabath; K M Koehler; W Q Yang; K Patton; George Stamatoyannopoulos
Identification of a major positive regulatory element located 5' to the human zeta-globin gene.
Blood 1995;85(9):2587-97.
1995: G Zitnik; K Peterson; George Stamatoyannopoulos; Thalia Papayannopoulou
Effects of butyrate and glucocorticoids on gamma- to beta-globin gene switching in somatic cell hybrids.
Molecular and cellular biology 1995;15(2):790-5.
1995: T Furukawa; Patrick A Navas; B M Josephson; Kenneth R Peterson; Thalia Papayannopoulou; George Stamatoyannopoulos
Coexpression of epsilon, G gamma and A gamma globin mRNA in embryonic red blood cells from a single copy beta-YAC transgenic mouse.
Blood cells, molecules & diseases 1995;21(2):168-78.
1994: B Pace; Qiliang Li; K Peterson; George Stamatoyannopoulos
alpha-Amino butyric acid cannot reactivate the silenced gamma gene of the beta locus YAC transgenic mouse.
Blood 1994;84(12):4344-53.
1994: George Stamatoyannopoulos; C Anthony Blau; Betty Nakamoto; B Josephson; Qiliang Li; E Liakopoulou; B Pace; Thalia Papayannopoulou; S W Brusilow; George J Dover
Fetal hemoglobin induction by acetate, a product of butyrate catabolism.
Blood 1994;84(9):3198-204.
1994: Qiliang Li; George Stamatoyannopoulos
Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator.
Blood 1994;84(5):1399-401.
1994: C Anthony Blau; George Stamatoyannopoulos
Hemoglobin switching and its clinical implications.
Current opinion in hematology 1994;1(2):136-42.
1994: T Furukawa; G Zitnik; Kathleen A Leppig; Thalia Papayannopoulou; George Stamatoyannopoulos
Coexpression of gamma and beta globin mRNA in cells containing a single human beta globin locus: results from studies using single-cell reverse transcription polymerase chain reaction.
Blood 1994;83(5):1412-9.
1994: B S Pace; H L Elford; George Stamatoyannopoulos
Transgenic mouse model of pharmacologic induction of fetal hemoglobin: studies using a new ribonucleotide reductase inhibitor, Didox.
American journal of hematology 1994;45(2):136-41.
1993: Kenneth R Peterson; G Zitnik; C Huxley; C H Lowrey; A Gnirke; Kathleen A Leppig; Thalia Papayannopoulou; George Stamatoyannopoulos
Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11207-11.
1993: George Stamatoyannopoulos; B Josephson; J W Zhang; Qiliang Li
Developmental regulation of human gamma-globin genes in transgenic mice.
Molecular and cellular biology 1993;13(12):7636-44.
1993: Daniel E Sabath; E A Spangler; E M Rubin; George Stamatoyannopoulos
Analysis of the human zeta-globin gene promoter in transgenic mice.
Blood 1993;82(9):2899-905.
1993: Kenneth R Peterson; CH Clegg; C Huxley; B M Josephson; Harald S Haugen; T Furukawa; George Stamatoyannopoulos
Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7593-7.
1993: G Zitnik; Qiliang Li; George Stamatoyannopoulos; Thalia Papayannopoulou
Serum factors can modulate the developmental clock of gamma- to beta-globin gene switching in somatic cell hybrids.
Molecular and cellular biology 1993;13(8):4844-51.
1993: Kenneth R Peterson; George Stamatoyannopoulos
Role of gene order in developmental control of human gamma- and beta-globin gene expression.
Molecular and cellular biology 1993;13(8):4836-43.
1993: C Anthony Blau; P Constantoulakis; C M Shaw; George Stamatoyannopoulos
Fetal hemoglobin induction with butyric acid: efficacy and toxicity.
Blood 1993;81(2):529-37.
1993: Kenneth R Peterson; CH Clegg; C Huxley; B M Josephson; Harald S Haugen; T Furukawa; George Stamatoyannopoulos
Transgenic mice containing a 248-kilobase human beta locus yeast artificial chromosome display proper developmental control of human globin genes.
Transactions of the Association of American Physicians 1993;106():101-9.
1993: C Anthony Blau; P Constantoulakis; A al-Khatti; E Spadaccino; E Goldwasser; Thalia Papayannopoulou; George Stamatoyannopoulos
Fetal hemoglobin in acute and chronic states of erythroid expansion.
Blood 1993;81(1):227-33.
1992: P Constantoulakis; Maggie Walmsley; Roger Patient; Thalia Papayannopoulou; T Enver; George Stamatoyannopoulos
Cell lines produce factors that induce fetal hemoglobin in human BFUe-derived colonies.
Blood 1992;80(10):2650-5.
1992: N Raich; Thalia Papayannopoulou; George Stamatoyannopoulos; T Enver
Demonstration of a human epsilon-globin gene silencer with studies in transgenic mice.
Blood 1992;79(4):861-4.
1991: T Enver; M Brice; Joyce E Karlinsey; George Stamatoyannopoulos; Thalia Papayannopoulou
Developmental regulation of fetal to adult globin gene switching in human fetal erythroid x mouse erythroleukemia cell hybrids.
Developmental biology 1991;148(1):129-37.
1991: George Stamatoyannopoulos
Human hemoglobin switching.
Science (New York, N.Y.) 1991;252(5004):383.
1991: G Zitnik; P Hines; George Stamatoyannopoulos; Thalia Papayannopoulou
Murine erythroleukemia cell line GM979 contains factors that can activate silent chromosomal human gamma-globin genes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2530-4.
1991: P Constantoulakis; B Josephson; L Mangahas; Thalia Papayannopoulou; T Enver; F Costantini; George Stamatoyannopoulos
Locus control region-A gamma transgenic mice: a new model for studying the induction of fetal hemoglobin in the adult.
Blood 1991;77(6):1326-33.
1990: N Raich; T Enver; Betty Nakamoto; B Josephson; Thalia Papayannopoulou; George Stamatoyannopoulos
Autonomous developmental control of human embryonic globin gene switching in transgenic mice.
Science (New York, N.Y.) 1990;250(4984):1147-9.
1990: Anna Rita Migliaccio; G Migliaccio; M Brice; P Constantoulakis; George Stamatoyannopoulos; Thalia Papayannopoulou
Influence of recombinant hematopoietins and of fetal bovine serum on the globin synthetic pattern of human BFUe.
Blood 1990;76(6):1150-7.
1990: P Constantoulakis; Betty Nakamoto; Thalia Papayannopoulou; George Stamatoyannopoulos
Fetal calf serum contains activities that induce fetal hemoglobin in adult erythroid cell cultures.
Blood 1990;75(9):1862-9.
1990: T Enver; N Raich; A J Ebens; Thalia Papayannopoulou; F Costantini; George Stamatoyannopoulos
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice.
Nature 1990;344(6264):309-13.
1990: J W Zhang; N Raich; T Enver; N P Anagnou; George Stamatoyannopoulos
Butyrate induces expression of transfected human fetal and endogenous mouse embryonic globin genes in GM 979 erythroleukemia cells.
Developmental genetics 1990;11(2):168-74.
1990: P Constantoulakis; F Costantini; B Josephson; D Fry; L Mangahas; George Stamatoyannopoulos
A transgenic mouse model for studying the induction of fetal hemoglobin in the adult.
Transactions of the Association of American Physicians 1990;103():80-9.
1990: George Stamatoyannopoulos; N Raich; A Ebens; B Josephson; Betty Nakamoto; P Constantoulakis; F Costantini; Thalia Papayannopoulou; T Enver
Analysis of human gamma-to-beta switching in transgenic mice.
Annals of the New York Academy of Sciences 1990;612():127-33.
1990: Thalia Papayannopoulou; M Brice; T Enver; George Stamatoyannopoulos
Globin gene switching: insights from studies in somatic heterospecific hybrids and in transgenic mice.
Progress in clinical and biological research 1990;352():323-8.
1990: George Stamatoyannopoulos; R Veith; A al-Khatti; Thalia Papayannopoulou
Induction of fetal hemoglobin by cell-cycle-specific drugs and recombinant erythropoietin.
The American journal of pediatric hematology/oncology 1990;12(1):21-6.
1989: P Constantoulakis; G Knitter; George Stamatoyannopoulos
On the induction of fetal hemoglobin by butyrates: in vivo and in vitro studies with sodium butyrate and comparison of combination treatments with 5-AzaC and AraC.
Blood 1989;74(6):1963-71.
1989: T Umemura; A al-Khatti; R E Donahue; Thalia Papayannopoulou; George Stamatoyannopoulos
Effects of interleukin-3 and erythropoietin on in vivo erythropoiesis and F-cell formation in primates.
Blood 1989;74(5):1571-6.
1989: T Enver; A J Ebens; W C Forrester; George Stamatoyannopoulos
The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):7033-7.
1989: Joyce E Karlinsey; George Stamatoyannopoulos; T Enver
Simultaneous purification of DNA and RNA from small numbers of eukaryotic cells.
Analytical biochemistry 1989;180(2):303-6.
1989: T Umemura; Thalia Papayannopoulou; George Stamatoyannopoulos
The mechanism of expansion of late erythroid progenitors during erythroid regeneration: target cells and effects of erythropoietin and interleukin-3.
Blood 1989;73(7):1993-8.
1989: P Constantoulakis; G Knitter; George Stamatoyannopoulos
Butyrate stimulates HbF in adult baboons.
Progress in clinical and biological research 1989;316B():351-61.
1989: George Stamatoyannopoulos; T Umemura; A al-Khatti; E Spadaccino; R I Abels; E F Fritsch; Thalia Papayannopoulou
Modulation of HBF production by erythropoietin.
Progress in clinical and biological research 1989;316B():269-80.
1989: T Cotner; A D Gupta; Thalia Papayannopoulou; George Stamatoyannopoulos
Characterization of a novel form of transferrin receptor preferentially expressed on normal erythroid progenitors and precursors.
Blood 1989;73(1):214-21.
1988: P Constantoulakis; Thalia Papayannopoulou; George Stamatoyannopoulos
alpha-Amino-N-butyric acid stimulates fetal hemoglobin in the adult.
Blood 1988;72(6):1961-7.
1988: T Umemura; A Al-Khatti; Thalia Papayannopoulou; George Stamatoyannopoulos
Fetal hemoglobin synthesis in vivo: direct evidence for control at the level of erythroid progenitors.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9278-82.
1988: Thalia Papayannopoulou; T Enver; S Takegawa; N P Anagnou; George Stamatoyannopoulos
Activation of developmentally mutated human globin genes by cell fusion.
Science (New York, N.Y.) 1988;242(4881):1056-8.
1988: T Enver; J W Zhang; N P Anagnou; George Stamatoyannopoulos; Thalia Papayannopoulou
Developmental programs of human erythroleukemia cells: globin gene expression and methylation.
Molecular and cellular biology 1988;8(11):4917-26.
1988: J W Zhang; George Stamatoyannopoulos; N P Anagnou
Laotian (delta beta) (0)-thalassemia: molecular characterization of a novel deletion associated with increased production of fetal hemoglobin.
Blood 1988;72(3):983-8.
1988: A Al-Khatti; Thalia Papayannopoulou; G Knitter; E F Fritsch; George Stamatoyannopoulos
Cooperative enhancement of F-cell formation in baboons treated with erythropoietin and hydroxyurea.
Blood 1988;72(2):817-9.
1988: N P Anagnou; Thalia Papayannopoulou; A W Nienhuis; George Stamatoyannopoulos
Molecular characterization of a novel form of (A gamma delta beta)zero-thalassemia deletion with a 3' breakpoint close to those of HPFH-3 and HPFH-4: insights for a common regulatory mechanism.
Nucleic acids research 1988;16(13):6057-66.
1988: T Enver; J W Zhang; Thalia Papayannopoulou; George Stamatoyannopoulos
DNA methylation: a secondary event in globin gene switching?
Genes & development 1988;2(6):698-706.
1988: R E Gelinas; M Rixon; W Magis; George Stamatoyannopoulos
Gamma gene promoter and enhancer structure in Seattle variant of hereditary persistence of fetal hemoglobin.
Blood 1988;71(4):1108-12.
1988: R Galanello; George Stamatoyannopoulos; Thalia Papayannopoulou
Mechanism of Hb F stimulation by S-stage compounds. In vitro studies with bone marrow cells exposed to 5-azacytidine, Ara-C, or hydroxyurea.
The Journal of clinical investigation 1988;81(4):1209-16.
1988: P E Nute; George Stamatoyannopoulos
Cases of abnormal human hemoglobin produced by de novo mutation.
Hemoglobin 1988;12(4):429-39.
1988: A al-Khatti; T Umemura; J Clow; R I Abels; J Vance; Thalia Papayannopoulou; George Stamatoyannopoulos
Erythropoietin stimulates F-reticulocyte formation in sickle cell anemia.
Transactions of the Association of American Physicians 1988;101():54-61.
1987: W C Forrester; S Takegawa; Thalia Papayannopoulou; George Stamatoyannopoulos; Mark Groudine
Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids.
Nucleic acids research 1987;15(24):10159-77.
1987: M Melis; G Demopulos; Vesna Najfeld; J W Zhang; M Brice; Thalia Papayannopoulou; George Stamatoyannopoulos
A chromosome 11-linked determinant controls fetal globin expression and the fetal-to-adult globin switch.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(22):8105-9.
1987: George Stamatoyannopoulos; P Constantoulakis; M Brice; S Kurachi; Thalia Papayannopoulou
Coexpression of embryonic, fetal, and adult globins in erythroid cells of human embryos: relevance to the cell-lineage models of globin switching.
Developmental biology 1987;123(1):191-7.
1987: A Al-Khatti; R W Veith; Thalia Papayannopoulou; E F Fritsch; E Goldwasser; George Stamatoyannopoulos
Stimulation of fetal hemoglobin synthesis by erythropoietin in baboons.
The New England journal of medicine 1987;317(7):415-20.
1987: George Stamatoyannopoulos; R Veith; A Al-Khatti; E F Fritsch; E Goldwasser; Thalia Papayannopoulou
On the induction of fetal hemoglobin in the adult; stress erythropoiesis, cell cycle-specific drugs, and recombinant erythropoietin.
Progress in clinical and biological research 1987;251():443-53.
1986: P G Waber; MA Bender; R E Gelinas; C Kattamis; A Karaklis; K Sofroniadou; George Stamatoyannopoulos; Francis S Collins; B G Forget; Haig Kazazian
Concordance of a point mutation 5' to the A gamma-globin gene with A gamma beta + hereditary persistence of fetal hemoglobin in Greeks.
Blood 1986;67(2):551-4.
1984: Thalia Papayannopoulou; B Tatsis; S Kurachi; Betty Nakamoto; George Stamatoyannopoulos
A haemoglobin switching activity modulates hereditary persistence of fetal haemoglobin.
Nature 1984;309(5963):71-3.
1983: George Stamatoyannopoulos; Betty Nakamoto; S Kurachi; Thalia Papayannopoulou
Direct evidence for interaction between human erythroid progenitor cells and a hemoglobin switching activity present in fetal sheep serum.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(18):5650-4.
1983: Thalia Papayannopoulou; Betty Nakamoto; S Kurachi; George Stamatoyannopoulos
Hemoglobin switching activity: target cells and direct evidence for a role of environment to cell interactions in Hb F to Hb A switching.
Transactions of the Association of American Physicians 1983;96():252-60.
1983: George Stamatoyannopoulos; Thalia Papayannopoulou; Betty Nakamoto; S Kurachi
Hemoglobin switching activity.
Progress in clinical and biological research 1983;134():347-63.
1982: Thalia Papayannopoulou; S Kurachi; Betty Nakamoto; E D Zanjani; George Stamatoyannopoulos
Hemoglobin switching in culture: evidence for a humoral factor that induces switching in adult and neonatal but not fetal erythroid cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(21):6579-83.
1981: Thalia Papayannopoulou; Betty Nakamoto; S Kurachi; George Stamatoyannopoulos
Globin synthesis in erythroid bursts that mature sequentially in culture. I. Studies in cultures of adult peripheral blood BFU-Es.
Blood 1981;58(5):969-74.
1981: Thalia Papayannopoulou; S Kurachi; M Brice; Betty Nakamoto; George Stamatoyannopoulos
Asynchronous synthesis of HbF and HbA during erythroblast maturation. II. Studies of G gamma, A gamma, and beta chain synthesis in individual erythroid clones from neonatal and adult BFU-E cultures.
Blood 1981;57(3):531-6.