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George Stark

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George R Stark; James E Darnell
The JAK-STAT pathway at twenty.
Min-Han Tan; Robert Wesolowski; Mohammed S Orloff; George R Stark; Gurkan Bebek; G Thomas Budd; Sarmishtha De; Erinn Downs-Kelly; Charis Eng
Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer.
Joana A Zula; Holly C Green; Richard M Ransohoff; Richard A Rudick; George R Stark; Anette H H van Boxel-Dezaire
The role of cell type-specific responses in IFN-β therapy of multiple sclerosis.

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2012: George R Stark; James E Darnell
The JAK-STAT pathway at twenty.
Immunity 2012;36(4):503-14.
2012: Min-Han Tan; Robert Wesolowski; Mohammed S Orloff; George R Stark; Gurkan Bebek; G Thomas Budd; Sarmishtha De; Erinn Downs-Kelly; Charis Eng
Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer.
Breast cancer research and treatment 2012;131(3):849-58.
2011: Joana A Zula; Holly C Green; Richard M Ransohoff; Richard A Rudick; George R Stark; Anette H H van Boxel-Dezaire
The role of cell type-specific responses in IFN-β therapy of multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(49):19689-94.
2011: Nathaniel Sears; Ganes C Sen; George R Stark; Saurabh Chattopadhyay
Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation.
The Journal of biological chemistry 2011;286(38):33037-44.
2011: Canhui Guo; George R Stark
FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7968-73.
2011: Olga A Guryanova; Qiulian Wu; Lin Cheng; Justin D Lathia; Zhi Huang; Jinbo Yang; Jennifer MacSwords; Christine E Eyler; Roger E McLendon; John M Heddleston; Weinian Shou; Dolores Hambardzumyan; Jeongwu Lee; Anita B Hjelmeland; Andrew E Sloan; Markus Bredel; George R Stark; Jeremy Rich; Shideng Bao
Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.
Cancer cell 2011;19(4):498-511.
2011: Youzhong Wan; Tae Whan Kim; Minjia Yu; Hao Zhou; Michifumi Yamashita; Zizhen Kang; Weiguo Yin; Jian-An Wang; James Thomas; Ganes C Sen; George R Stark; Xiaoxia Li
The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(5):3006-14.
2011: HyeonJoo Cheon; Jinbo Yang; George R Stark
The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2011;31(1):33-40.
2010: Anette H H van Boxel-Dezaire; Joana A Zula; Yaomin Xu; Richard M Ransohoff; James W Jacobberger; George R Stark
Major differences in the responses of primary human leukocyte subsets to IFN-beta.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(10):5888-99.
2010: Youzhong Wan; Maojing Yang; Sunny Kolattukudy; George R Stark; Tao Lu
Activation of cAMP-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor β2 in cancer cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010;30(9):677-81.
2010: Tao Lu; George R Stark
Use of forward genetics to discover novel regulators of NF-kappaB.
Cold Spring Harbor perspectives in biology 2010;2(6):a001966.
2010: Tao Lu; Mark Jackson; Benlian Wang; Maojing Yang; Mark R Chance; Masaru Miyagi; Andrei V Gudkov; George R Stark
Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):46-51.
2009: David B Shultz; M R Sandhya Rani; John D Fuller; Richard M Ransohoff; George R Stark
Roles of IKK-beta, IRF1, and p65 in the activation of chemokine genes by interferon-gamma.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2009;29(12):817-24.
2009: Tao Lu; Mark Jackson; Aatur D Singhi; Eugene S Kandel; Maojing Yang; Yi Zhang; Andrei V Gudkov; George R Stark
Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16339-44.
2009: HyeonJoo Cheon; George R Stark
Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9373-8.
2009: Youzhong Wan; Hui Xiao; Jeremy Affolter; Tae Whan Kim; Katarzyna Bulek; Sujan Chaudhuri; Deborah Carlson; Thomas Hamilton; Barsanjit Mazumder; George R Stark; James Thomas; Xiaoxia Li
Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control.
The Journal of biological chemistry 2009;284(16):10367-75.
2008: Maupali Dasgupta; Mukesh K Agarwal; Patrick Varley; Tao Lu; George R Stark; Eugene S Kandel
Transposon-based mutagenesis identifies short RIP1 as an activator of NFkappaB.
Cell cycle (Georgetown, Tex.) 2008;7(14):2249-56.
2008: Kedar Hastak; Rajib K Paul; Mukesh K Agarwal; Vijay S Thakur; Ashok Amin; Sudesh Agrawal; R Michael Sramkoski; James Jacobberger; Mark Jackson; George R Stark; Munna L Agarwal
DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6314-9.
2007: Ernest C Borden; Ganes C Sen; Gilles Uze; Robert H Silverman; Richard M Ransohoff; Graham R Foster; George R Stark
Interferons at age 50: past, current and future impact on biomedicine.
Nature reviews. Drug discovery 2007;6(12):975-90.
2007: Charlene E Kan; John T Patton; George R Stark; Mark Jackson
p53-mediated growth suppression in response to Nutlin-3 in cyclin D1 transformed cells occurs independently of p21.
Cancer research 2007;67(20):9862-8.
2007: David B Shultz; John D Fuller; Yonghui Yang; Nywana Sizemore; M R Sandhya Rani; George R Stark
Activation of a subset of genes by IFN-gamma requires IKKbeta but not interferon-dependent activation of NF-kappaB.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(10):875-84.
2007: George R Stark
How cells respond to interferons revisited: from early history to current complexity.
Cytokine & growth factor reviews 2007;18(5-6):419-23.
2007: Sudesh Agrawal; Maria Febbraio; Eugene A Podrez; Martha K Cathcart; George R Stark; Guy M Chisolm
Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development.
Circulation 2007;115(23):2939-47.
2007: Jinbo Yang; Xudong Liao; Mukesh K Agarwal; Laura Barnes; Philip E. auron; George R Stark
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB.
Genes & development 2007;21(11):1396-408.
2007: Tao Lu; Liping Tian; Yulong Han; Michael A Vogelbaum; George R Stark
Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4365-70.
2007: Anette H H van Boxel-Dezaire; George R Stark
Cell type-specific signaling in response to interferon-gamma.
Current topics in microbiology and immunology 2007;316():119-54.
2006: Mukesh K Agarwal; Kedar Hastak; Mark Jackson; Samuel N Breit; George R Stark; Munna L Agarwal
Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16278-83.
2006: Anette H H van Boxel-Dezaire; M R Sandhya Rani; George R Stark
Complex modulation of cell type-specific signaling in response to type I interferons.
Immunity 2006;25(3):361-72.
2006: Mark Jackson; Linnea E Patt; Gretchen A LaRusch; David B Donner; George R Stark; Lindsey D Mayo
Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells.
The Journal of biological chemistry 2006;281(24):16814-20.
2006: John T Patton; Lindsey D Mayo; Aatur D Singhi; Andrei V Gudkov; George R Stark; Mark Jackson
Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3.
Cancer research 2006;66(6):3169-76.
2006: George R Stark; William R Taylor
Control of the G2/M transition.
Molecular biotechnology 2006;32(3):227-48.
2005: Katerina V Gurova; Jason E Hill; Canhui Guo; Anatoly Prokvolit; Lyudmila G Burdelya; Eugenia Samoylova; Anna V Khodyakova; Ram Ganapathi; Mahrukh K Ganapathi; Natalia D Tararova; Dmitry Bosykh; Dmitriy Lvovskiy; Thomas R Webb; George R Stark; Andrei V Gudkov
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(48):17448-53.
2005: Joao T Marques; Dominique Rebouillat; chilakamarti ramana; Junko Murakami; Jason E Hill; Andrei Gudkov; Robert H Silverman; George R Stark; Bryan R G Williams
Down-regulation of p53 by double-stranded RNA modulates the antiviral response.
Journal of virology 2005;79(17):11105-14.
2005: Eugene S Kandel; Tao Lu; Youzhong Wan; Mukesh K Agarwal; Mark Jackson; George R Stark
Mutagenesis by reversible promoter insertion to study the activation of NF-kappaB.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6425-30.
2005: Mark Jackson; Mukesh K Agarwal; Jinbo Yang; Patrick Bruss; Takeshi Uchiumi; Munna L Agarwal; George R Stark; William R Taylor
p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2.
Journal of cell science 2005;118(Pt 9):1821-32.
2005: Jinbo Yang; Moitreyee Chatterjee-Kishore; Susan M Staugaitis; Hannah Nguyen; Karni Schlessinger; David E Levy; George R Stark
Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation.
Cancer research 2005;65(3):939-47.
2005: Yulan Qing; Ana P Costa-Pereira; Diane Watling; George R Stark
Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation.
The Journal of biological chemistry 2005;280(3):1849-53.
2004: Yulan Qing; George R Stark
Alternative activation of STAT1 and STAT3 in response to interferon-gamma.
The Journal of biological chemistry 2004;279(40):41679-85.
2004: Tao Lu; George R Stark
Cytokine overexpression and constitutive NFkappaB in cancer.
Cell cycle (Georgetown, Tex.) 2004;3(9):1114-7.
2004: Mark Jackson; Mukesh K Agarwal; Munna L Agarwal; Archana Agarwal; Patricia Stanhope-Baker; Bryan R G Williams; George R Stark
Limited role of N-terminal phosphoserine residues in the activation of transcription by p53.
Oncogene 2004;23(25):4477-87.
2004: Nywana Sizemore; Anju Agarwal; Kingshuk Das; Natalia Lerner; Michael Sulak; Sandhya Rani; Richard M Ransohoff; David Shultz; George R Stark
Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7994-8.
2004: Tao Lu; Lyudmila G Burdelya; Shannon M Swiatkowski; Alexander D. Boiko; Philip H Howe; George R Stark; Andrei V Gudkov
Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7112-7.
2004: Tao Lu; Swati S Sathe; Shannon M Swiatkowski; Chetan V Hampole; George R Stark
Secretion of cytokines and growth factors as a general cause of constitutive NFkappaB activation in cancer.
Oncogene 2004;23(12):2138-45.
2004: Swati S Sathe; Nywana Sizemore; Xiaoxia Li; Kalpa Vithalani; Mairead Commane; Shannon M Swiatkowski; George R Stark
Mutant human cells with constitutive activation of NF-kappaB.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):192-7.
2004: George R Stark; William R Taylor
Analyzing the G2/M checkpoint.
Methods in molecular biology (Clifton, N.J.) 2004;280():51-82.
2003: Brad Clifford; Milos Beljin; George R Stark; William R Taylor
G2 arrest in response to topoisomerase II inhibitors: the role of p53.
Cancer research 2003;63(14):4074-81.
2003: Hannah Nguyen; Moitreyee Chatterjee-Kishore; Zhengfan Jiang; Yulan Qing; chilakamarti ramana; Joshua Bayes; Mairead Commane; Xiaoxia Li; George R Stark
IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2003;23(4):183-92.
2002: M R Sandhya Rani; Linda Hibbert; Nywana Sizemore; George R Stark; Richard M Ransohoff
Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene.
The Journal of biological chemistry 2002;277(41):38456-61.
2002: Mamta Chawla-Sarkar; Douglas W Leaman; Barbara S Jacobs; Ralph J Tuthill; Moitreyee Chatterjee-Kishore; George R Stark; Ernest C Borden
Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1).
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(5):603-13.
2002: Kristi L Peters; Heather L Smith; George R Stark; Ganes C Sen
IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6322-7.
2002: Xiaoxia Li; George R Stark
NFkappaB-dependent signaling pathways.
Experimental hematology 2002;30(4):285-96.
2002: Sudesh Agrawal; Munna L Agarwal; Moitreyee Chatterjee-Kishore; George R Stark; Guy M Chisolm
Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis.
Molecular and cellular biology 2002;22(7):1981-92.
2002: Nywana Sizemore; Natalia Lerner; Nicole Dombrowski; Hiroaki Sakurai; George R Stark
Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.
The Journal of biological chemistry 2002;277(6):3863-9.
2002: chilakamarti ramana; M Pilar Gil; Robert D Schreiber; George R Stark
Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling.
Trends in immunology 2002;23(2):96-101.
2002: Lora J H Bean; George R Stark
Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2.
The Journal of biological chemistry 2002;277(3):1864-71.
2002: T Charis Wagner; Sharlene Velichko; David Vogel; M R Sandhya Rani; Stewart Leung; Richard M Ransohoff; George R Stark; H Daniel Perez; Ed Croze
Interferon signaling is dependent on specific tyrosines located within the intracellular domain of IFNAR2c. Expression of IFNAR2c tyrosine mutants in U5A cells.
The Journal of biological chemistry 2002;277(2):1493-9.
2001: Dave Wald; Mairead Commane; George R Stark; Xiaoxia Li
IRAK and TAK1 are required for IL-18-mediated signaling.
European journal of immunology 2001;31(12):3747-54.
2001: M R Sandhya Rani; A R Asthagiri; A Singh; Nywana Sizemore; Swati S Sathe; Xiaoxia Li; J D DiDonato; George R Stark; Richard M Ransohoff
A role for NF-kappa B in the induction of beta-R1 by interferon-beta.
The Journal of biological chemistry 2001;276(48):44365-8.
2001: Hannah Nguyen; chilakamarti ramana; J Bayes; George R Stark
Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression.
The Journal of biological chemistry 2001;276(36):33361-8.
2001: Mikhail V Chernov; Lora J H Bean; Natalia Lerner; George R Stark
Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation.
The Journal of biological chemistry 2001;276(34):31819-24.
2001: M Pilar Gil; E Bohn; Andy K O'Guin; chilakamarti ramana; Beth Levine; George R Stark; Herbert W Virgin; Robert D Schreiber
Biologic consequences of Stat1-independent IFN signaling.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6680-5.
2001: chilakamarti ramana; M Pilar Gil; Yulong Han; Richard M Ransohoff; Robert D Schreiber; George R Stark
Stat1-independent regulation of gene expression in response to IFN-gamma.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6674-9.
2001: Munna L Agarwal; chilakamarti ramana; M Hamilton; William R Taylor; S E DePrimo; Lora J H Bean; Ashok Agarwal; Mukesh K Agarwal; Alan Wolfman; George R Stark
Regulation of p53 expression by the RAS-MAP kinase pathway.
Oncogene 2001;20(20):2527-36.
2001: Xiaoxia Li; Mairead Commane; Zhengfan Jiang; George R Stark
IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4461-5.
2001: William R Taylor; George R Stark
Regulation of the G2/M transition by p53.
Oncogene 2001;20(15):1803-15.
2001: Lora J H Bean; George R Stark
Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.
Oncogene 2001;20(9):1076-84.
2001: WR Taylor; A H Schonthal; J Galante; George R Stark
p130/E2F4 binds to and represses the cdc2 promoter in response to p53.
The Journal of biological chemistry 2001;276(3):1998-2006.
2000: Xiaoxia Li; Mairead Commane; H Nie; Xianxin Hua; Moitreyee Chatterjee-Kishore; Dave Wald; M Haag; George R Stark
Act1, an NF-kappa B-activating protein.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10489-93.
2000: Moitreyee Chatterjee-Kishore; K L Wright; Jenny P-Y Ting; George R Stark
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene.
The EMBO journal 2000;19(15):4111-22.
2000: Moitreyee Chatterjee-Kishore; Focco Van Den Akker; George R Stark
Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1.
The Journal of biological chemistry 2000;275(27):20406-11.
2000: chilakamarti ramana; Moitreyee Chatterjee-Kishore; Hannah Nguyen; George R Stark
Complex roles of Stat1 in regulating gene expression.
Oncogene 2000;19(21):2619-27.
2000: E B Albrecht; A B Hunyady; George R Stark; Thomas E Patterson
Mechanisms of sod2 gene amplification in Schizosaccharomyces pombe.
Molecular biology of the cell 2000;11(3):873-86.
2000: Moitreyee Chatterjee-Kishore; Focco Van Den Akker; George R Stark
Association of STATs with relatives and friends.
Trends in cell biology 2000;10(3):106-11.
2000: chilakamarti ramana; Nicholas Grammatikakis; Mikhail V Chernov; Hannah Nguyen; KC Goh; Bryan R G Williams; George R Stark
Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.
The EMBO journal 2000;19(2):263-72.
1999: William R Taylor; S E DePrimo; A Agarwal; Munna L Agarwal; A H Schönthal; K S Katula; George R Stark
Mechanisms of G2 arrest in response to overexpression of p53.
Molecular biology of the cell 1999;10(11):3607-22.
1999: Thomas E Patterson; E B Albrecht; Paul Nurse; Shelley Sazer; George R Stark
Effects of genome position and the DNA damage checkpoint on the structure and frequency of sod2 gene amplification in fission yeast.
Molecular biology of the cell 1999;10(7):2199-208.
1999: Nywana Sizemore; Stewart Leung; George R Stark
Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit.
Molecular and cellular biology 1999;19(7):4798-805.
1999: Xiaoxia Li; Mairead Commane; C Burns; K Vithalani; Z Cao; George R Stark
Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase.
Molecular and cellular biology 1999;19(7):4643-52.
1999: William R Taylor; Munna L Agarwal; Ashok Agarwal; Dennis W Stacey; George R Stark
p53 inhibits entry into mitosis when DNA synthesis is blocked.
Oncogene 1999;18(2):283-95.
1998: Munna L Agarwal; Anju Agarwal; WR Taylor; Olga Chernova; Y Sharma; George R Stark
A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14775-80.
1998: Douglas W Leaman; A Salvekar; Rekha C Patel; Ganes C Sen; George R Stark
A mutant cell line defective in response to double-stranded RNA and in regulating basal expression of interferon-stimulated genes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9442-7.
1998: Xiaoxia Li; Stewart Leung; C Burns; George R Stark
Cooperative binding of Stat1-2 heterodimers and ISGF3 to tandem DNA elements.
Biochimie 1998;80(8-9):703-10.
1998: Mikhail V Chernov; chilakamarti ramana; V V Adler; George R Stark
Stabilization and activation of p53 are regulated independently by different phosphorylation events.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2284-9.
1998: Munna L Agarwal; WR Taylor; Mikhail V Chernov; Olga Chernova; George R Stark
The p53 network.
The Journal of biological chemistry 1998;273(1):1-4.
1998: Olga Chernova; Mikhail V Chernov; Y Ishizaka; Munna L Agarwal; George R Stark
MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification.
Molecular and cellular biology 1998;18(1):536-45.
1997: A Kumar; Mairead Commane; T W Flickinger; Curt M Horvath; George R Stark
Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases.
Science (New York, N.Y.) 1997;278(5343):1630-2.
1997: Munna L Agarwal; Ashok Agarwal; William R Taylor; Z Q Wang; E F Wagner; George R Stark
Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase.
Oncogene 1997;15(9):1035-41.
1997: S Jaharul Haque; Q Wu; W Kammer; Karlheinz Friedrich; J M Smith; I M Kerr; George R Stark; Bryan R G Williams
Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8563-8.
1997: K Shimoda; Jian Feng; H Murakami; S Nagata; Diane Watling; Neil C Rogers; George R Stark; Ian M Kerr; James N Ihle
Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor.
Blood 1997;90(2):597-604.
1997: Yulong Han; Diane Watling; Neil C Rogers; George R Stark
JAK2 and STAT5, but not JAK1 and STAT1, are required for prolactin-induced beta-lactoglobulin transcription.
Molecular endocrinology (Baltimore, Md.) 1997;11(8):1180-8.
1997: M V Chernov; George R Stark
The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylate.
Oncogene 1997;14(21):2503-10.
1997: Xiaoxia Li; Stewart Leung; I M Kerr; George R Stark
Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.
Molecular and cellular biology 1997;17(4):2048-56.
1997: Elena A Komarova; Mikhail V Chernov; Roberta Franks; K Wang; G Armin; CR Zelnick; Dot Mon Chin; Sarah S Bacus; George R Stark; Andrei V Gudkov
Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo.
The EMBO journal 1997;16(6):1391-400.
1997: K A Smith; Olga Chernova; R P Groves; M B Stark; J L Martínez; J N Davidson; Jeffrey M. Trent; Thomas E Patterson; A Agarwal; P Duncan; Munna L Agarwal; George R Stark
Multiple mechanisms of N-phosphonacetyl-L-aspartate resistance in human cell lines: carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1816-21.
1997: F Kohlhuber; Neil C Rogers; Diane Watling; Jian Feng; D Guschin; J Briscoe; bruce witthuhn; Sergei V Kotenko; Sidney Pestka; George R Stark; James N Ihle; Ian M Kerr
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
Molecular and cellular biology 1997;17(2):695-706.
1996: Douglas W Leaman; Stewart Leung; Xiaoxia Li; George R Stark
Regulation of STAT-dependent pathways by growth factors and cytokines.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(14):1578-88.
1996: Curt M Horvath; George R Stark; Ian M Kerr; James E Darnell
Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.
Molecular and cellular biology 1996;16(12):6957-64.
1996: V S Ossovskaya; Ilya Mazo; Mikhail V Chernov; Olga Chernova; Z Strezoska; R Kondratov; George R Stark; Peter Chumakov; Andrei V Gudkov
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10309-14.
1996: M R Sandhya Rani; G R Foster; Stewart Leung; Douglas W Leaman; George R Stark; Richard M Ransohoff
Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha.
The Journal of biological chemistry 1996;271(37):22878-84.
1996: Stewart Leung; Xiaoxia Li; George R Stark
STATs find that hanging together can be stimulating.
Science (New York, N.Y.) 1996;273(5276):750-1.
1996: Yulong Han; Douglas W Leaman; Diane Watling; Neil C Rogers; B Groner; Ian M Kerr; W I Wood; George R Stark
Participation of JAK and STAT proteins in growth hormone-induced signaling.
The Journal of biological chemistry 1996;271(10):5947-52.
1996: Xiaoxia Li; Stewart Leung; S Qureshi; J E Darnell; George R Stark
Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha.
The Journal of biological chemistry 1996;271(10):5790-4.
1996: J Briscoe; D Guschin; Neil C Rogers; Diane Watling; M Müller; F Horn; P Heinrich; George R Stark; Ian M Kerr
JAKs, STATs and signal transduction in response to the interferons and other cytokines.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):167-71.
1996: J Briscoe; Neil C Rogers; bruce witthuhn; Diane Watling; A G Harpur; Andrew Wilks; George R Stark; James N Ihle; Ian M Kerr
Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.
The EMBO journal 1996;15(4):799-809.
1996: Douglas W Leaman; S Pisharody; T W Flickinger; Mairead Commane; J Schlessinger; Ian M Kerr; David E Levy; George R Stark
Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor.
Molecular and cellular biology 1996;16(1):369-75.
1996: S A Qureshi; S Leung; Ian M Kerr; George R Stark; James E Darnell
Function of Stat2 protein in transcriptional activation by alpha interferon.
Molecular and cellular biology 1996;16(1):288-93.
1995: H T Lu; J L Riley; G T Babcock; M Huston; George R Stark; Jeremy M Boss; Richard M Ransohoff
Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma.
The Journal of experimental medicine 1995;182(5):1517-25.
1995: Thomas E Patterson; George R Stark; Shelley Sazer
A strategy for quickly identifying all unique two-hybrid or library plasmids within a pool of yeast transformants.
Nucleic acids research 1995;23(20):4222-3.
1995: Olga Chernova; Mikhail V Chernov; Munna L Agarwal; William R Taylor; George R Stark
The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited.
Trends in biochemical sciences 1995;20(10):431-4.
1995: Munna L Agarwal; Ashok Agarwal; William R Taylor; George R Stark
p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8493-7.
1995: S K Bandyopadhyay; G T Leonard; T Bandyopadhyay; George R Stark; Ganes C Sen
Transcriptional induction by double-stranded RNA is mediated by interferon-stimulated response elements without activation of interferon-stimulated gene factor 3.
The Journal of biological chemistry 1995;270(33):19624-9.
1995: Y Ishizaka; Mikhail V Chernov; C M Burns; George R Stark
p53-dependent growth arrest of REF52 cells containing newly amplified DNA.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3224-8.
1995: D Guschin; Neil C Rogers; J Briscoe; bruce witthuhn; Diane Watling; F Horn; S Pellegrini; K Yasukawa; P Heinrich; George R Stark
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.
The EMBO journal 1995;14(7):1421-9.
1995: M H Heim; Ian M Kerr; George R Stark; James E Darnell
Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway.
Science (New York, N.Y.) 1995;267(5202):1347-9.
1995: Stewart Leung; S A Qureshi; Ian M Kerr; J E Darnell; George R Stark
Role of STAT2 in the alpha interferon signaling pathway.
Molecular and cellular biology 1995;15(3):1312-7.
1995: K A Smith; Munna L Agarwal; Mikhail V Chernov; Olga Chernova; Y Deguchi; Y Ishizaka; T E Patterson; M F Poupon; George R Stark
Regulation and mechanisms of gene amplification.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1995;347(1319):49-56.
1994: KC Chin; C Mao; C Skinner; J L Riley; Kenneth L Wright; Carlos S Moreno; George R Stark; Jeremy M Boss; Jenny P-Y Ting
Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction.
Immunity 1994;1(8):687-97.
1994: James E Darnell; Ian M Kerr; George R Stark
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
Science (New York, N.Y.) 1994;264(5164):1415-21.
1994: R McKendry; Sandra Pellegrini; Ian M Kerr; George R Stark
Constitutive production of alpha and beta interferons in mutant human cell lines.
Journal of virology 1994;68(6):4057-62.
1994: T Improta; Christian Schindler; Curt M Horvath; Ian M Kerr; George R Stark; James E Darnell
Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4776-80.
1993: Diane Watling; D Guschin; M Müller; O Silvennoinen; bruce witthuhn; F W Quelle; Neil C Rogers; Christian Schindler; George R Stark; James N Ihle
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.
Nature 1993;366(6451):166-70.
1993: M Müller; C Laxton; J Briscoe; Christian Schindler; T Improta; James E Darnell; George R Stark; Ian M Kerr
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.
The EMBO journal 1993;12(11):4221-8.
1993: Ke Shuai; George R Stark; Ian M Kerr; James E Darnell
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.
Science (New York, N.Y.) 1993;261(5129):1744-6.
1993: J Parrington; N C Rogers; D R Gewert; R Pine; S A Veals; David E Levy; George R Stark; Ian M Kerr
The interferon-stimulable response elements of two human genes detect overlapping sets of transcription factors.
European journal of biochemistry / FEBS 1993;214(3):617-26.
1993: C Mao; D Davies; Ian M Kerr; George R Stark
Mutant human cells defective in induction of major histocompatibility complex class II genes by interferon gamma.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2880-4.
1993: George R Stark
Regulation and mechanisms of mammalian gene amplification.
Advances in cancer research 1993;61():87-113.
1992: M E Perry; M Commane; George R Stark
Simian virus 40 large tumor antigen alone or two cooperating oncogenes convert REF52 cells to a state permissive for gene amplification.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8112-6.
1992: L Velazquez; Marc Fellous; George R Stark; Sandra Pellegrini
A protein tyrosine kinase in the interferon alpha/beta signaling pathway.
Cell 1992;70(2):313-22.
1992: K A Smith; M B Stark; P A Gorman; George R Stark
Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5427-31.
1991: R McKendry; J John; D Flavell; M Müller; Ian M Kerr; George R Stark
High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11455-9.
1991: A M Ackrill; Graham R Foster; C D Laxton; D M Flavell; George R Stark; Ian M Kerr
Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene.
Nucleic acids research 1991;19(16):4387-93.
1991: J John; R McKendry; Sandra Pellegrini; D Flavell; Ian M Kerr; George R Stark
Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons.
Molecular and cellular biology 1991;11(8):4189-95.
1991: Ian M Kerr; George R Stark
The control of interferon-inducible gene expression.
FEBS letters 1991;285(2):194-8.
1991: A R Lewin; L E Reid; M McMahon; George R Stark; Ian M Kerr
Molecular analysis of a human interferon-inducible gene family.
European journal of biochemistry / FEBS 1991;199(2):417-23.
1991: Graham R Foster; A M Ackrill; R D Goldin; Ian M Kerr; Howard Thomas; George R Stark
Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2888-92.
1991: A M Ackrill; L E Reid; C S Gilbert; D R Gewert; Andrew C G Porter; A R Lewin; George R Stark; Ian M Kerr
Differential response of the human 6-16 and 9-27 genes to alpha and gamma interferons.
Nucleic acids research 1991;19(3):591-8.
1990: K A Smith; P A Gorman; M B Stark; R P Groves; George R Stark
Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells.
Cell 1990;63(6):1219-27.
1990: A M Imam; A M Ackrill; T C Dale; Ian M Kerr; George R Stark
Transcription factors induced by interferons alpha and gamma.
Nucleic acids research 1990;18(22):6573-80.
1990: J A Wright; HS Smith; F M Watt; M C Hancock; D L Hudson; George R Stark
DNA amplification is rare in normal human cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1791-5.
1989: Sandra Pellegrini; J John; M Shearer; Ian M Kerr; George R Stark
Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.
Molecular and cellular biology 1989;9(11):4605-12.
1989: George R Stark; M Debatisse; E Giulotto; G M Wahl
Recent progress in understanding mechanisms of mammalian DNA amplification.
Cell 1989;57(6):901-8.
1989: I Saito; R Groves; E Giulotto; M Rolfe; George R Stark
Evolution and stability of chromosomal DNA coamplified with the CAD gene.
Molecular and cellular biology 1989;9(6):2445-52.
1989: T C Dale; J M Rosen; M J Guille; A R Lewin; A G Porter; Ian M Kerr; George R Stark
Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription.
The EMBO journal 1989;8(3):831-9.
1989: T C Dale; A M Imam; Ian M Kerr; George R Stark
Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(4):1203-7.
1989: L E Reid; A H Brasnett; C S Gilbert; Andrew C G Porter; D R Gewert; George R Stark; Ian M Kerr
A single DNA response element can confer inducibility by both alpha- and gamma-interferons.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):840-4.
1988: S M Kerr; George R Stark; Ian M Kerr
Excess antisense RNA from infectious recombinant SV40 fails to inhibit expression of a transfected, interferon-inducible gene.
European journal of biochemistry / FEBS 1988;175(1):65-73.
1988: Andrew C G Porter; Y Chernajovsky; T C Dale; C S Gilbert; George R Stark; Ian M Kerr
Interferon response element of the human gene 6-16.
The EMBO journal 1988;7(1):85-92.
1986: J M Kelly; Andrew C G Porter; Y Chernajovsky; C S Gilbert; George R Stark; Ian M Kerr
Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells.
The EMBO journal 1986;5(7):1601-6.
1985: J M Kelly; C S Gilbert; George R Stark; Ian M Kerr
Differential regulation of interferon-induced mRNAs and c-myc mRNA by alpha- and gamma-interferons.
European journal of biochemistry / FEBS 1985;153(2):367-71.