George Stark

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Lu Tao; Jackson Mark W; Singhi Aatur D; Kandel Eugene S; Yang Maojing; Zhang Yi; Gudkov Andrei V; Stark George R
Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.
Cheon Hyeonjoo; Stark George R
Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes.
Wan Youzhong; Xiao Hui; Affolter Jeremy; Kim Tae Whan; Bulek Katarzyna; Chaudhuri Sujan; Carlson Deborah; Hamilton Thomas; Mazumder Barsanjit; Stark George R; Thomas James; Li Xiaoxia
Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control.

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All Publications

2009: Lu Tao; Jackson Mark W; Singhi Aatur D; Kandel Eugene S; Yang Maojing; Zhang Yi; Gudkov Andrei V; Stark George R
Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16339-44.
2009: Cheon Hyeonjoo; Stark George R
Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9373-8.
2009: Wan Youzhong; Xiao Hui; Affolter Jeremy; Kim Tae Whan; Bulek Katarzyna; Chaudhuri Sujan; Carlson Deborah; Hamilton Thomas; Mazumder Barsanjit; Stark George R; Thomas James; Li Xiaoxia
Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control.
The Journal of biological chemistry 2009;284(16):10367-75.
2008: Dasgupta Maupali; Agarwal Mukesh K; Varley Patrick; Lu Tao; Stark George R; Kandel Eugene S
Transposon-based mutagenesis identifies short RIP1 as an activator of NFkappaB.
Cell cycle (Georgetown, Tex.) 2008;7(14):2249-56.
2008: Hastak Kedar; Paul Rajib K; Agarwal Mukesh K; Thakur Vijay S; Amin A R M Ruhul; Agrawal Sudesh; Sramkoski R Michael; Jacobberger James W; Jackson Mark W; Stark George R; Agarwal Munna L
DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6314-9.
2007: Borden Ernest C; Sen Ganes C; Uze Gilles; Silverman Robert H; Ransohoff Richard M; Foster Graham R; Stark George R
Interferons at age 50: past, current and future impact on biomedicine.
Nature reviews. Drug discovery 2007;6(12):975-90.
2007: Shultz David B; Fuller John D; Yang Yonghui; Sizemore Nywana; Rani M R Sandhya; Stark George R
Activation of a subset of genes by IFN-gamma requires IKKbeta but not interferon-dependent activation of NF-kappaB.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2007;27(10):875-84.
2007: Kan Charlene E; Patton John T; Stark George R; Jackson Mark W
p53-mediated growth suppression in response to Nutlin-3 in cyclin D1 transformed cells occurs independently of p21.
Cancer research 2007;67(20):9862-8.
2007: Stark George R
How cells respond to interferons revisited: from early history to current complexity.
Cytokine & growth factor reviews 2007;18(5-6):419-23.
2007: Agrawal Sudesh; Febbraio Maria; Podrez Eugene; Cathcart Martha K; Stark George R; Chisolm Guy M
Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development.
Circulation 2007;115(23):2939-47.
2007: Yang Jinbo; Liao Xudong; Agarwal Mukesh K; Barnes Laura; Auron Philip E; Stark George R
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB.
Genes & development 2007;21(11):1396-408.
2007: Lu Tao; Tian Liping; Han Yulong; Vogelbaum Michael; Stark George R
Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4365-70.
2007: van Boxel-Dezaire A H H; Stark G R
Cell type-specific signaling in response to interferon-gamma.
Current topics in microbiology and immunology 2007;316():119-54.
2006: Agarwal Mukesh K; Hastak Kedar; Jackson Mark W; Breit Samuel N; Stark George R; Agarwal Munna L
Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16278-83.
2006: van Boxel-Dezaire Anette H H; Rani M R Sandhya; Stark George R
Complex modulation of cell type-specific signaling in response to type I interferons.
Immunity 2006;25(3):361-72.
2006: Jackson Mark W; Patt Linnea E; LaRusch Gretchen A; Donner David B; Stark George R; Mayo Lindsey D
Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells.
The Journal of biological chemistry 2006;281(24):16814-20.
2006: Stark George R; Taylor William R
Control of the G2/M transition.
Molecular biotechnology 2006;32(3):227-48.
2006: Patton John T; Mayo Lindsey D; Singhi Aatur D; Gudkov Andrei V; Stark George R; Jackson Mark W
Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3.
Cancer research 2006;66(6):3169-76.
2005: Gurova Katerina V; Hill Jason E; Guo Canhui; Prokvolit Anatoly; Burdelya Lyudmila G; Samoylova Eugenia; Khodyakova Anna V; Ganapathi Ram; Ganapathi Mahrukh; Tararova Natalia D; Bosykh Dmitry; Lvovskiy Dmitriy; Webb Thomas R; Stark George R; Gudkov Andrei V
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(48):17448-53.
2005: Marques Joao T; Rebouillat Dominique; Ramana Chilakamarti V; Murakami Junko; Hill Jason E; Gudkov Andrei; Silverman Robert H; Stark George R; Williams Bryan R G
Down-regulation of p53 by double-stranded RNA modulates the antiviral response.
Journal of virology 2005;79(17):11105-14.
2005: Kandel Eugene S; Lu Tao; Wan Youzhong; Agarwal Mukesh K; Jackson Mark W; Stark George R
Mutagenesis by reversible promoter insertion to study the activation of NF-kappaB.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6425-30.
2005: Jackson Mark W; Agarwal Mukesh K; Yang Jinbo; Bruss Patrick; Uchiumi Takeshi; Agarwal Munna L; Stark George R; Taylor William R
p130/p107/p105Rb-dependent transcriptional repression during DNA-damage-induced cell-cycle exit at G2.
Journal of cell science 2005;118(Pt 9):1821-32.
2005: Yang Jinbo; Chatterjee-Kishore Moitreyee; Staugaitis Susan M; Nguyen Hannah; Schlessinger Karni; Levy David E; Stark George R
Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation.
Cancer research 2005;65(3):939-47.
2005: Qing Yulan; Costa-Pereira Ana P; Watling Diane; Stark George R
Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation.
The Journal of biological chemistry 2005;280(3):1849-53.
2004: Qing Yulan; Stark George R
Alternative activation of STAT1 and STAT3 in response to interferon-gamma.
The Journal of biological chemistry 2004;279(40):41679-85.
2004: Lu Tao; Stark George R
Cytokine overexpression and constitutive NFkappaB in cancer.
Cell cycle (Georgetown, Tex.) 2004;3(9):1114-7.
2004: Sizemore Nywana; Agarwal Anju; Das Kingshuk; Lerner Natalia; Sulak Michael; Rani Sandhya; Ransohoff Richard; Shultz David; Stark George R
Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7994-8.
2004: Lu Tao; Burdelya Lyudmila G; Swiatkowski Shannon M; Boiko Alexander D; Howe Philip H; Stark George R; Gudkov Andrei V
Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):7112-7.
2004: Jackson Mark W; Agarwal Mukesh K; Agarwal Munna L; Agarwal Archana; Stanhope-Baker Patricia; Williams Bryan R G; Stark George R
Limited role of N-terminal phosphoserine residues in the activation of transcription by p53.
Oncogene 2004;23(25):4477-87.
2004: Lu Tao; Sathe Swati S; Swiatkowski Shannon M; Hampole Chetan V; Stark George R
Secretion of cytokines and growth factors as a general cause of constitutive NFkappaB activation in cancer.
Oncogene 2004;23(12):2138-45.
2004: Sathe Swati S; Sizemore Nywana; Li Xiaoxia; Vithalani Kalpa; Commane Mairead; Swiatkowski Shannon M; Stark George R
Mutant human cells with constitutive activation of NF-kappaB.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):192-7.
2004: Stark George R; Taylor William R
Analyzing the G2/M checkpoint.
Methods in molecular biology (Clifton, N.J.) 2004;280():51-82.
2003: Clifford Brad; Beljin Milos; Stark George R; Taylor William R
G2 arrest in response to topoisomerase II inhibitors: the role of p53.
Cancer research 2003;63(14):4074-81.
2003: Nguyen Hannah; Chatterjee-Kishore Moitreyee; Jiang Zhengfan; Qing Yulan; Ramana Chilakamarti V; Bayes Joshua; Commane Mairead; Li Xiaoxia; Stark George R
IRAK-dependent phosphorylation of Stat1 on serine 727 in response to interleukin-1 and effects on gene expression.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2003;23(4):183-92.
2002: Rani M R Sandhya; Hibbert Linda; Sizemore Nywana; Stark George R; Ransohoff Richard M
Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene.
The Journal of biological chemistry 2002;277(41):38456-61.
2002: Chawla-Sarkar Mamta; Leaman Douglas W; Jacobs Barbara S; Tuthill Ralph J; Chatterjee-Kishore Moitreyee; Stark George R; Borden Ernest C
Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1).
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(5):603-13.
2002: Peters Kristi L; Smith Heather L; Stark George R; Sen Ganes C
IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6322-7.
2002: Li Xiaoxia; Stark George R
NFkappaB-dependent signaling pathways.
Experimental hematology 2002;30(4):285-96.
2002: Agrawal Sudesh; Agarwal Munna L; Chatterjee-Kishore Moitreyee; Stark George R; Chisolm Guy M
Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis.
Molecular and cellular biology 2002;22(7):1981-92.
2002: Ramana Chilakamarti V; Gil M Pilar; Schreiber Robert D; Stark George R
Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling.
Trends in immunology 2002;23(2):96-101.
2002: Sizemore Nywana; Lerner Natalia; Dombrowski Nicole; Sakurai Hiroaki; Stark George R
Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.
The Journal of biological chemistry 2002;277(6):3863-9.
2002: Bean Lora J H; Stark George R
Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2.
The Journal of biological chemistry 2002;277(3):1864-71.
2002: Wagner T Charis; Velichko Sharlene; Vogel David; Rani M R Sandhya; Leung Stewart; Ransohoff Richard M; Stark George R; Perez H Daniel; Croze Ed
Interferon signaling is dependent on specific tyrosines located within the intracellular domain of IFNAR2c. Expression of IFNAR2c tyrosine mutants in U5A cells.
The Journal of biological chemistry 2002;277(2):1493-9.
2001: Wald D; Commane M; Stark G R; Li X
IRAK and TAK1 are required for IL-18-mediated signaling.
European journal of immunology 2001;31(12):3747-54.
2001: Rani M R; Asthagiri A R; Singh A; Sizemore N; Sathe S S; Li X; DiDonato J D; Stark G R; Ransohoff R M
A role for NF-kappa B in the induction of beta-R1 by interferon-beta.
The Journal of biological chemistry 2001;276(48):44365-8.
2001: Nguyen H; Ramana C V; Bayes J; Stark G R
Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression.
The Journal of biological chemistry 2001;276(36):33361-8.
2001: Chernov M V; Bean L J; Lerner N; Stark G R
Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation.
The Journal of biological chemistry 2001;276(34):31819-24.
2001: Gil M P; Bohn E; O'Guin A K; Ramana C V; Levine B; Stark G R; Virgin H W; Schreiber R D
Biologic consequences of Stat1-independent IFN signaling.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6680-5.
2001: Ramana C V; Gil M P; Han Y; Ransohoff R M; Schreiber R D; Stark G R
Stat1-independent regulation of gene expression in response to IFN-gamma.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6674-9.
2001: Agarwal M L; Ramana C V; Hamilton M; Taylor W R; DePrimo S E; Bean L J; Agarwal A; Agarwal M K; Wolfman A; Stark G R
Regulation of p53 expression by the RAS-MAP kinase pathway.
Oncogene 2001;20(20):2527-36.
2001: Taylor W R; Stark G R
Regulation of the G2/M transition by p53.
Oncogene 2001;20(15):1803-15.
2001: Li X; Commane M; Jiang Z; Stark G R
IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4461-5.
2001: Bean L J; Stark G R
Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.
Oncogene 2001;20(9):1076-84.
2001: Taylor W R; Schonthal A H; Galante J; Stark G R
p130/E2F4 binds to and represses the cdc2 promoter in response to p53.
The Journal of biological chemistry 2001;276(3):1998-2006.
2000: Li X; Commane M; Nie H; Hua X; Chatterjee-Kishore M; Wald D; Haag M; Stark G R
Act1, an NF-kappa B-activating protein.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(19):10489-93.
2000: Chatterjee-Kishore M; Wright K L; Ting J P; Stark G R
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene.
The EMBO journal 2000;19(15):4111-22.
2000: Chatterjee-Kishore M; van Den Akker F; Stark G R
Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1.
The Journal of biological chemistry 2000;275(27):20406-11.
2000: Ramana C V; Chatterjee-Kishore M; Nguyen H; Stark G R
Complex roles of Stat1 in regulating gene expression.
Oncogene 2000;19(21):2619-27.
2000: Albrecht E B; Hunyady A B; Stark G R; Patterson T E
Mechanisms of sod2 gene amplification in Schizosaccharomyces pombe.
Molecular biology of the cell 2000;11(3):873-86.
2000: Chatterjee-Kishore M; van den Akker F; Stark G R
Association of STATs with relatives and friends.
Trends in cell biology 2000;10(3):106-11.
2000: Ramana C V; Grammatikakis N; Chernov M; Nguyen H; Goh K C; Williams B R; Stark G R
Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways.
The EMBO journal 2000;19(2):263-72.
1999: Taylor W R; DePrimo S E; Agarwal A; Agarwal M L; Schönthal A H; Katula K S; Stark G R
Mechanisms of G2 arrest in response to overexpression of p53.
Molecular biology of the cell 1999;10(11):3607-22.
1999: Patterson T E; Albrecht E B; Nurse P; Sazer S; Stark G R
Effects of genome position and the DNA damage checkpoint on the structure and frequency of sod2 gene amplification in fission yeast.
Molecular biology of the cell 1999;10(7):2199-208.
1999: Sizemore N; Leung S; Stark G R
Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit.
Molecular and cellular biology 1999;19(7):4798-805.
1999: Li X; Commane M; Burns C; Vithalani K; Cao Z; Stark G R
Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase.
Molecular and cellular biology 1999;19(7):4643-52.
1999: Taylor W R; Agarwal M L; Agarwal A; Stacey D W; Stark G R
p53 inhibits entry into mitosis when DNA synthesis is blocked.
Oncogene 1999;18(2):283-95.
1998: Agarwal M L; Agarwal A; Taylor W R; Chernova O; Sharma Y; Stark G R
A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14775-80.
1998: Li X; Leung S; Burns C; Stark G R
Cooperative binding of Stat1-2 heterodimers and ISGF3 to tandem DNA elements.
Biochimie 1998;80(8-9):703-10.
1998: Leaman D W; Salvekar A; Patel R; Sen G C; Stark G R
A mutant cell line defective in response to double-stranded RNA and in regulating basal expression of interferon-stimulated genes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9442-7.
1998: Chernov M V; Ramana C V; Adler V V; Stark G R
Stabilization and activation of p53 are regulated independently by different phosphorylation events.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2284-9.
1998: Chernova O B; Chernov M V; Ishizaka Y; Agarwal M L; Stark G R
MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification.
Molecular and cellular biology 1998;18(1):536-45.
1998: Agarwal M L; Taylor W R; Chernov M V; Chernova O B; Stark G R
The p53 network.
The Journal of biological chemistry 1998;273(1):1-4.
1997: Kumar A; Commane M; Flickinger T W; Horvath C M; Stark G R
Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases.
Science (New York, N.Y.) 1997;278(5343):1630-2.
1997: Agarwal M L; Agarwal A; Taylor W R; Wang Z Q; Wagner E F; Stark G R
Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase.
Oncogene 1997;15(9):1035-41.
1997: Haque S J; Wu Q; Kammer W; Friedrich K; Smith J M; Kerr I M; Stark G R; Williams B R
Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8563-8.
1997: Shimoda K; Feng J; Murakami H; Nagata S; Watling D; Rogers N C; Stark G R; Kerr I M; Ihle J N
Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor.
Blood 1997;90(2):597-604.
1997: Han Y; Watling D; Rogers N C; Stark G R
JAK2 and STAT5, but not JAK1 and STAT1, are required for prolactin-induced beta-lactoglobulin transcription.
Molecular endocrinology (Baltimore, Md.) 1997;11(8):1180-8.
1997: Chernov M V; Stark G R
The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylate.
Oncogene 1997;14(21):2503-10.
1997: Li X; Leung S; Kerr I M; Stark G R
Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.
Molecular and cellular biology 1997;17(4):2048-56.
1997: Komarova E A; Chernov M V; Franks R; Wang K; Armin G; Zelnick C R; Chin D M; Bacus S S; Stark G R; Gudkov A V
Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo.
The EMBO journal 1997;16(6):1391-400.
1997: Smith K A; Chernova O B; Groves R P; Stark M B; Martínez J L; Davidson J N; Trent J M; Patterson T E; Agarwal A; Duncan P; Agarwal M L; Stark G R
Multiple mechanisms of N-phosphonacetyl-L-aspartate resistance in human cell lines: carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1816-21.
1997: Kohlhuber F; Rogers N C; Watling D; Feng J; Guschin D; Briscoe J; Witthuhn B A; Kotenko S V; Pestka S; Stark G R; Ihle J N; Kerr I M
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
Molecular and cellular biology 1997;17(2):695-706.
1996: Leaman D W; Leung S; Li X; Stark G R
Regulation of STAT-dependent pathways by growth factors and cytokines.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(14):1578-88.
1996: Horvath C M; Stark G R; Kerr I M; Darnell J E
Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.
Molecular and cellular biology 1996;16(12):6957-64.
1996: Ossovskaya V S; Mazo I A; Chernov M V; Chernova O B; Strezoska Z; Kondratov R; Stark G R; Chumakov P M; Gudkov A V
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10309-14.
1996: Rani M R; Foster G R; Leung S; Leaman D; Stark G R; Ransohoff R M
Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha.
The Journal of biological chemistry 1996;271(37):22878-84.
1996: Leung S; Li X; Stark G R
STATs find that hanging together can be stimulating.
Science (New York, N.Y.) 1996;273(5276):750-1.
1996: Han Y; Leaman D W; Watling D; Rogers N C; Groner B; Kerr I M; Wood W I; Stark G R
Participation of JAK and STAT proteins in growth hormone-induced signaling.
The Journal of biological chemistry 1996;271(10):5947-52.
1996: Li X; Leung S; Qureshi S; Darnell J E; Stark G R
Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha.
The Journal of biological chemistry 1996;271(10):5790-4.
1996: Briscoe J; Guschin D; Rogers N C; Watling D; Müller M; Horn F; Heinrich P; Stark G R; Kerr I M
JAKs, STATs and signal transduction in response to the interferons and other cytokines.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):167-71.
1996: Briscoe J; Rogers N C; Witthuhn B A; Watling D; Harpur A G; Wilks A F; Stark G R; Ihle J N; Kerr I M
Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.
The EMBO journal 1996;15(4):799-809.
1996: Leaman D W; Pisharody S; Flickinger T W; Commane M A; Schlessinger J; Kerr I M; Levy D E; Stark G R
Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor.
Molecular and cellular biology 1996;16(1):369-75.
1996: Qureshi S A; Leung S; Kerr I M; Stark G R; Darnell J E
Function of Stat2 protein in transcriptional activation by alpha interferon.
Molecular and cellular biology 1996;16(1):288-93.
1995: Lu H T; Riley J L; Babcock G T; Huston M; Stark G R; Boss J M; Ransohoff R M
Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma.
The Journal of experimental medicine 1995;182(5):1517-25.
1995: Chernova O B; Chernov M V; Agarwal M L; Taylor W R; Stark G R
The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited.
Trends in biochemical sciences 1995;20(10):431-4.
1995: Patterson T E; Stark G R; Sazer S
A strategy for quickly identifying all unique two-hybrid or library plasmids within a pool of yeast transformants.
Nucleic acids research 1995;23(20):4222-3.
1995: Agarwal M L; Agarwal A; Taylor W R; Stark G R
p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8493-7.
1995: Bandyopadhyay S K; Leonard G T; Bandyopadhyay T; Stark G R; Sen G C
Transcriptional induction by double-stranded RNA is mediated by interferon-stimulated response elements without activation of interferon-stimulated gene factor 3.
The Journal of biological chemistry 1995;270(33):19624-9.
1995: Ishizaka Y; Chernov M V; Burns C M; Stark G R
p53-dependent growth arrest of REF52 cells containing newly amplified DNA.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3224-8.
1995: Guschin D; Rogers N; Briscoe J; Witthuhn B; Watling D; Horn F; Pellegrini S; Yasukawa K; Heinrich P; Stark G R
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.
The EMBO journal 1995;14(7):1421-9.
1995: Heim M H; Kerr I M; Stark G R; Darnell J E
Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway.
Science (New York, N.Y.) 1995;267(5202):1347-9.
1995: Leung S; Qureshi S A; Kerr I M; Darnell J E; Stark G R
Role of STAT2 in the alpha interferon signaling pathway.
Molecular and cellular biology 1995;15(3):1312-7.
1995: Smith K A; Agarwal M L; Chernov M V; Chernova O B; Deguchi Y; Ishizaka Y; Patterson T E; Poupon M F; Stark G R
Regulation and mechanisms of gene amplification.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1995;347(1319):49-56.
1994: Chin K C; Mao C; Skinner C; Riley J L; Wright K L; Moreno C S; Stark G R; Boss J M; Ting J P
Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction.
Immunity 1994;1(8):687-97.
1994: Darnell J E; Kerr I M; Stark G R
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
Science (New York, N.Y.) 1994;264(5164):1415-21.
1994: McKendry R; Pellegrini S; Kerr I M; Stark G R
Constitutive production of alpha and beta interferons in mutant human cell lines.
Journal of virology 1994;68(6):4057-62.
1994: Improta T; Schindler C; Horvath C M; Kerr I M; Stark G R; Darnell J E
Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4776-80.
1993: Watling D; Guschin D; Müller M; Silvennoinen O; Witthuhn B A; Quelle F W; Rogers N C; Schindler C; Stark G R; Ihle J N
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.
Nature 1993;366(6451):166-70.
1993: Müller M; Laxton C; Briscoe J; Schindler C; Improta T; Darnell J E; Stark G R; Kerr I M
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways.
The EMBO journal 1993;12(11):4221-8.
1993: Shuai K; Stark G R; Kerr I M; Darnell J E
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.
Science (New York, N.Y.) 1993;261(5129):1744-6.
1993: Parrington J; Rogers N C; Gewert D R; Pine R; Veals S A; Levy D E; Stark G R; Kerr I M
The interferon-stimulable response elements of two human genes detect overlapping sets of transcription factors.
European journal of biochemistry / FEBS 1993;214(3):617-26.
1993: Mao C; Davies D; Kerr I M; Stark G R
Mutant human cells defective in induction of major histocompatibility complex class II genes by interferon gamma.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2880-4.
1993: Stark G R
Regulation and mechanisms of mammalian gene amplification.
Advances in cancer research 1993;61():87-113.
1992: Perry M E; Commane M; Stark G R
Simian virus 40 large tumor antigen alone or two cooperating oncogenes convert REF52 cells to a state permissive for gene amplification.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8112-6.
1992: Velazquez L; Fellous M; Stark G R; Pellegrini S
A protein tyrosine kinase in the interferon alpha/beta signaling pathway.
Cell 1992;70(2):313-22.
1992: Smith K A; Stark M B; Gorman P A; Stark G R
Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5427-31.
1991: McKendry R; John J; Flavell D; Müller M; Kerr I M; Stark G R
High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11455-9.
1991: John J; McKendry R; Pellegrini S; Flavell D; Kerr I M; Stark G R
Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons.
Molecular and cellular biology 1991;11(8):4189-95.
1991: Ackrill A M; Foster G R; Laxton C D; Flavell D M; Stark G R; Kerr I M
Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene.
Nucleic acids research 1991;19(16):4387-93.
1991: Lewin A R; Reid L E; McMahon M; Stark G R; Kerr I M
Molecular analysis of a human interferon-inducible gene family.
European journal of biochemistry / FEBS 1991;199(2):417-23.
1991: Kerr I M; Stark G R
The control of interferon-inducible gene expression.
FEBS letters 1991;285(2):194-8.
1991: Foster G R; Ackrill A M; Goldin R D; Kerr I M; Thomas H C; Stark G R
Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2888-92.
1991: Ackrill A M; Reid L E; Gilbert C S; Gewert D R; Porter A C; Lewin A R; Stark G R; Kerr I M
Differential response of the human 6-16 and 9-27 genes to alpha and gamma interferons.
Nucleic acids research 1991;19(3):591-8.
1990: Smith K A; Gorman P A; Stark M B; Groves R P; Stark G R
Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells.
Cell 1990;63(6):1219-27.
1990: Imam A M; Ackrill A M; Dale T C; Kerr I M; Stark G R
Transcription factors induced by interferons alpha and gamma.
Nucleic acids research 1990;18(22):6573-80.
1990: Wright J A; Smith H S; Watt F M; Hancock M C; Hudson D L; Stark G R
DNA amplification is rare in normal human cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1791-5.
1989: Pellegrini S; John J; Shearer M; Kerr I M; Stark G R
Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.
Molecular and cellular biology 1989;9(11):4605-12.
1989: Stark G R; Debatisse M; Giulotto E; Wahl G M
Recent progress in understanding mechanisms of mammalian DNA amplification.
Cell 1989;57(6):901-8.
1989: Saito I; Groves R; Giulotto E; Rolfe M; Stark G R
Evolution and stability of chromosomal DNA coamplified with the CAD gene.
Molecular and cellular biology 1989;9(6):2445-52.
1989: Dale T C; Rosen J M; Guille M J; Lewin A R; Porter A G; Kerr I M; Stark G R
Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription.
The EMBO journal 1989;8(3):831-9.
1989: Dale T C; Imam A M; Kerr I M; Stark G R
Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(4):1203-7.
1989: Reid L E; Brasnett A H; Gilbert C S; Porter A C; Gewert D R; Stark G R; Kerr I M
A single DNA response element can confer inducibility by both alpha- and gamma-interferons.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):840-4.
1988: Kerr S M; Stark G R; Kerr I M
Excess antisense RNA from infectious recombinant SV40 fails to inhibit expression of a transfected, interferon-inducible gene.
European journal of biochemistry / FEBS 1988;175(1):65-73.
1988: Porter A C; Chernajovsky Y; Dale T C; Gilbert C S; Stark G R; Kerr I M
Interferon response element of the human gene 6-16.
The EMBO journal 1988;7(1):85-92.
1986: Kelly J M; Porter A C; Chernajovsky Y; Gilbert C S; Stark G R; Kerr I M
Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells.
The EMBO journal 1986;5(7):1601-6.
1985: Kelly J M; Gilbert C S; Stark G R; Kerr I M
Differential regulation of interferon-induced mRNAs and c-myc mRNA by alpha- and gamma-interferons.
European journal of biochemistry / FEBS 1985;153(2):367-71.

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