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Holger Stark

Research Profile

Procedures

Anatomy

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Image Processing, Computer-Assisted

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Escherichia coli

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TOP 3
Florian Hauer; Jan-Martin Kirves; Christoph Gerle; Holger Stark
Automated correlation of single particle tilt pairs for Random Conical Tilt and Orthogonal Tilt Reconstructions.
Kristina Uzunova; Georg Petzold; Ina Poser; Brenda A Schulman; Hannelore Schutz; Holger Stark; Yusuke Toyoda; Nicholas G Brown; Billy T Dye; Anthony A Hyman; Marc A Jarvis; Rene Ladurner; Karl Mechtler; Maria Novatchkova; Jan-Michael Peters
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.
Bettina A Buschhorn; Georg Petzold; Marta Galova; Prakash Dube; Claudine Kraft; Franz Herzog; Holger Stark; Jan-Michael Peters
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.

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All Publications

2013: Florian Hauer; Jan-Martin Kirves; Christoph Gerle; Holger Stark
Automated correlation of single particle tilt pairs for Random Conical Tilt and Orthogonal Tilt Reconstructions.
Journal of structural biology 2013;181(2):149-54.
2012: Kristina Uzunova; Georg Petzold; Ina Poser; Brenda A Schulman; Hannelore Schutz; Holger Stark; Yusuke Toyoda; Nicholas G Brown; Billy T Dye; Anthony A Hyman; Marc A Jarvis; Rene Ladurner; Karl Mechtler; Maria Novatchkova; Jan-Michael Peters
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.
Nature structural & molecular biology 2012;19(11):1116-23.
2011: Bettina A Buschhorn; Georg Petzold; Marta Galova; Prakash Dube; Claudine Kraft; Franz Herzog; Holger Stark; Jan-Michael Peters
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.
Nature structural & molecular biology 2011;18(1):6-13.
2010: Monika M Golas; Bjoern Sander; Sergey Bessonov; Michael Grote; Elmar Wolf; Berthold Kastner; Holger Stark; Reinhard Lührmann
3D cryo-EM structure of an active step I spliceosome and localization of its catalytic core.
Molecular cell 2010;40(6):927-38.
2010: Niels Fischer; Andrey Konevega; Wolfgang Wintermeyer; Marina V Rodnina; Holger Stark
Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy.
Nature 2010;466(7304):329-33.
2010: James Hutchins; Yusuke Toyoda; Björn Hegemann; Ina Poser; Jean-Karim Hériché; Martina M Sykora; Martina Augsburg; Otto Hudecz; Bettina A Buschhorn; Jutta Bulkescher; Christian Conrad; David Comartin; Alexander Schleiffer; Mihail Sarov; Andrei Pozniakovsky; Mikolaj Michal Slabicki; Siegfried Schloissnig; Ines Steinmacher; Marit Leuschner; Andrea Ssykor; Steffen Lawo; Laurence Pelletier; Holger Stark; Kim Nasmyth; Jan Ellenberg; Richard Durbin; Frank Buchholz; Karl Mechtler; Anthony A Hyman; Jan-Michael Peters
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Science (New York, N.Y.) 2010;328(5978):593-9.
2010: Senta Uzgün; Ozgür Akdemir; Günther Hasenpusch; Christof Maucksch; Monika M Golas; Bjoern Sander; Holger Stark; Rabea Imker; Jean-François Lutz; Carsten Rudolph
Characterization of tailor-made copolymers of oligo(ethylene glycol) methyl ether methacrylate and N,N-dimethylaminoethyl methacrylate as nonviral gene transfer agents: influence of macromolecular structure on gene vector particle properties and transfection efficiency.
Biomacromolecules 2010;11(1):39-50.
2009: Zbigniew Warkocki; Peter Odenwälder; Jana Schmitzová; Florian Platzmann; Holger Stark; Henning Urlaub; Ralf Ficner; Patrizia Fabrizio; Reinhard Lührmann
Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components.
Nature structural & molecular biology 2009;16(12):1237-43.
2009: Patrizia Fabrizio; Julia Dannenberg; Prakash Dube; Berthold Kastner; Holger Stark; Henning Urlaub; Reinhard Lührmann
The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome.
Molecular cell 2009;36(4):593-608.
2009: Markus Elfinger; Corinna Pfeifer; Senta Uezguen; Monika M Golas; Bjoern Sander; Christof Maucksch; Holger Stark; Manish Kumar Aneja; Carsten Rudolph
Self-assembly of ternary insulin-polyethylenimine (PEI)-DNA nanoparticles for enhanced gene delivery and expression in alveolar epithelial cells.
Biomacromolecules 2009;10(10):2912-20.
2009: Elmar Wolf; Berthold Kastner; Jochen Deckert; Christian Merz; Holger Stark; Reinhard Lührmann
Exon, intron and splice site locations in the spliceosomal B complex.
The EMBO journal 2009;28(15):2283-92.
2009: Martin Schmeisser; Burkhard C Heisen; Mario Luettich; Boris Busche; Florian Hauer; Tobias Koske; Karl-Heinz Knauber; Holger Stark
Parallel, distributed and GPU computing technologies in single-particle electron microscopy.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 7):659-71.
2009: Monika M Golas; Cordula Böhm; Bjoern Sander; Kerstin Effenberger; Michael Brecht; Holger Stark; H Ulrich Göringer
Snapshots of the RNA editing machine in trypanosomes captured at different assembly stages in vivo.
The EMBO journal 2009;28(6):766-78.
2009: Reinhard Lührmann; Holger Stark
Structural mapping of spliceosomes by electron microscopy.
Current opinion in structural biology 2009;19(1):96-102.
2008: Irina Häcker; Bjoern Sander; Monika M Golas; Elmar Wolf; Gulsun Elif Karagoz; Berthold Kastner; Holger Stark; Patrizia Fabrizio; Reinhard Lührmann
Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy.
Nature structural & molecular biology 2008;15(11):1206-12.
2008: Berthold Kastner; Niels Fischer; Monika M Golas; Bjoern Sander; Prakash Dube; Daniel Boehringer; Klaus Hartmuth; Jochen Deckert; Florian Hauer; Elmar Wolf; Hannes Uchtenhagen; Henning Urlaub; Franz Herzog; Jan Michael Peters; Dietmar Poerschke; Reinhard Lührmann; Holger Stark
GraFix: sample preparation for single-particle electron cryomicroscopy.
Nature methods 2008;5(1):53-5.
2007: Niels Fischer; Alena Paleskava; Kirill B Gromadski; Andrey Konevega; Markus C Wahl; Holger Stark; Marina V Rodnina
Towards understanding selenocysteine incorporation into bacterial proteins.
Biological chemistry 2007;388(10):1061-7.
2007: Andrey Konevega; Niels Fischer; Yuri P Semenkov; Holger Stark; Wolfgang Wintermeyer; Marina V Rodnina
Spontaneous reverse movement of mRNA-bound tRNA through the ribosome.
Nature structural & molecular biology 2007;14(4):318-24.
2007: Nastaran Behzadnia; Monika M Golas; Klaus Hartmuth; Bjoern Sander; Berthold Kastner; Jochen Deckert; Prakash Dube; Cindy L Will; Henning Urlaub; Holger Stark; Reinhard Lührmann
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.
The EMBO journal 2007;26(6):1737-48.
2006: Bjoern Sander; Monika M Golas; Evgeny M Makarov; Hero Brahms; Berthold Kastner; Reinhard Lührmann; Holger Stark
Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy.
Molecular cell 2006;24(2):267-78.
2006: Jochen Deckert; Klaus Hartmuth; Daniel Boehringer; Nastaran Behzadnia; Cindy L Will; Berthold Kastner; Holger Stark; Henning Urlaub; Reinhard Lührmann
Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.
Molecular and cellular biology 2006;26(14):5528-43.
2006: Holger Stark; Reinhard Lührmann
Cryo-electron microscopy of spliceosomal components.
Annual review of biophysics and biomolecular structure 2006;35():435-57.
2005: Prakash Dube; Franz Herzog; Christian Gieffers; Bjoern Sander; Dietmar Riedel; Shirley A Müller; Andreas Engel; Jan-Michael Peters; Holger Stark
Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.
Molecular cell 2005;20(6):867-79.
2005: Daniel Boehringer; Rolf Thermann; Antje Ostareck-Lederer; Joe D Lewis; Holger Stark
Structure of the hepatitis C virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES.
Structure (London, England : 1993) 2005;13(11):1695-706.
2005: Bjoern Sander; Monika M Golas; Holger Stark
Advantages of CCD detectors for de novo three-dimensional structure determination in single-particle electron microscopy.
Journal of structural biology 2005;151(1):92-105.
2005: Monika M Golas; Bjoern Sander; Cindy L Will; Reinhard Lührmann; Holger Stark
Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy.
Molecular cell 2005;17(6):869-83.
2004: Daniel Boehringer; Evgeny M Makarov; Bjoern Sander; Olga V Makarova; Berthold Kastner; Reinhard Lührmann; Holger Stark
Three-dimensional structure of a pre-catalytic human spliceosomal complex B.
Nature structural & molecular biology 2004;11(5):463-8.
2003: Bjoern Sander; Monika M Golas; Holger Stark
Corrim-based alignment for improved speed in single-particle image processing.
Journal of structural biology 2003;143(3):219-28.
2003: Bjoern Sander; Monika M Golas; Holger Stark
Automatic CTF correction for single particles based upon multivariate statistical analysis of individual power spectra.
Journal of structural biology 2003;142(3):392-401.
2003: Monika M Golas; Bjoern Sander; Cindy L Will; Reinhard Lührmann; Holger Stark
Molecular architecture of the multiprotein splicing factor SF3b.
Science (New York, N.Y.) 2003;300(5621):980-4.
2003: Ulrich Meissner; Michael Stohr; Kristina Kusche; Thorsten Burmester; Holger Stark; James Robinson Harris; Elena V Orlova; Jürgen Markl
Quaternary structure of the European spiny lobster (Palinurus elephas) 1x6-mer hemocyanin from cryoEM and amino acid sequence data.
Journal of molecular biology 2003;325(1):99-109.
2002: Holger Stark; Marina V Rodnina; Hans-Joachim Wieden; Friedrich Zemlin; Wolfgang Wintermeyer; Marin van Heel
Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex.
Nature structural biology 2002;9(11):849-54.
2002: Holger Stark
Three-dimensional electron cryomicroscopy of ribosomes.
Current protein & peptide science 2002;3(1):79-91.
2001: Christian Gieffers; Prakash Dube; J R Harris; Holger Stark; Jan-Michael Peters
Three-dimensional structure of the anaphase-promoting complex.
Molecular cell 2001;7(4):907-13.
2001: Tilmann Achsel; Holger Stark; Reinhard Lührmann
The Sm domain is an ancient RNA-binding motif with oligo(U) specificity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3685-9.
2001: Holger Stark; Prakash Dube; Reinhard Lührmann; Berthold Kastner
Arrangement of RNA and proteins in the spliceosomal U1 small nuclear ribonucleoprotein particle.
Nature 2001;409(6819):539-42.
2000: Marin van Heel; Brent Gowen; R Matadeen; Elena V Orlova; R Finn; Tillmann Pape; D Cohen; Holger Stark; R Schmidt; M Schatz; Ardan Patwardhan
Single-particle electron cryo-microscopy: towards atomic resolution.
Quarterly reviews of biophysics 2000;33(4):307-69.
2000: Marina V Rodnina; Holger Stark; Andreas Savelsbergh; Hans-Joachim Wieden; Dagmar Mohr; Natalia Matassova; Frank Peske; Tina Daviter; C O Gualerzi; Wolfgang Wintermeyer
GTPases mechanisms and functions of translation factors on the ribosome.
Biological chemistry 2000;381(5-6):377-87.
2000: Ulrich Meissner; P Dube; James Robinson Harris; Holger Stark; Jürgen Markl
Structure of a molluscan hemocyanin didecamer (HtH1 from Haliotis tuberculata) at 12 A resolution by cryoelectron microscopy.
Journal of molecular biology 2000;298(1):21-34.
2000: Holger Stark; Marina V Rodnina; Hans-Joachim Wieden; Marin van Heel; Wolfgang Wintermeyer
Large-scale movement of elongation factor G and extensive conformational change of the ribosome during translocation.
Cell 2000;100(3):301-9.
1998: P Dube; G Bacher; Holger Stark; Florian Mueller; Friedrich Zemlin; Marin van Heel; Richard Brimacombe
Correlation of the expansion segments in mammalian rRNA with the fine structure of the 80 S ribosome; a cryoelectron microscopic reconstruction of the rabbit reticulocyte ribosome at 21 A resolution.
Journal of molecular biology 1998;279(2):403-21.
1998: P Dube; M Wieske; Holger Stark; M Schatz; J Stahl; Friedrich Zemlin; Gudrun Lutsch; Marin van Heel
The 80S rat liver ribosome at 25 A resolution by electron cryomicroscopy and angular reconstitution.
Structure (London, England : 1993) 1998;6(3):389-99.
1997: Holger Stark; Marina V Rodnina; Jutta Rinke-Appel; Richard Brimacombe; Wolfgang Wintermeyer; Marin van Heel
Visualization of elongation factor Tu on the Escherichia coli ribosome.
Nature 1997;389(6649):403-6.
1997: Florian Mueller; Holger Stark; Marin van Heel; Jutta Rinke-Appel; Richard Brimacombe
A new model for the three-dimensional folding of Escherichia coli 16 S ribosomal RNA. III. The topography of the functional centre.
Journal of molecular biology 1997;271(4):566-87.
1997: Holger Stark; Elena V Orlova; Jutta Rinke-Appel; N Jünke; Florian Mueller; Marina V Rodnina; Wolfgang Wintermeyer; Richard Brimacombe; Marin van Heel
Arrangement of tRNAs in pre- and posttranslocational ribosomes revealed by electron cryomicroscopy.
Cell 1997;88(1):19-28.
1995: Holger Stark; Florian Mueller; Elena V Orlova; M Schatz; P Dube; T Erdemir; Friedrich Zemlin; Richard Brimacombe; Marin van Heel
The 70S Escherichia coli ribosome at 23 A resolution: fitting the ribosomal RNA.
Structure (London, England : 1993) 1995;3(8):815-21.