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Melissa Starovasnik

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Genes & Molecular Sequences

Amino Acid Sequences

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Gladys de Leon-Boenig; Christine Everett; Jianwen A Feng; Yvonne Franke; Krista K Bowman; Terry Crawford; Adam R Johnson; Angela Oh; Steven T Staben; Mark Stanley; Melissa A Starovasnik; Heidi J A Wallweber; Jiansheng Wu; Lawren C Wu; Sarah G Hymowitz
The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.
Xiaolei Ma; Qui T Phung; Clifford L Quan; Melissa A Starovasnik; Krista K Bowman; Elizabeth Helgason; Rekha S Iyer; Michelle W Lee; Erin C Dueber
Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Xiaolei Ma; Flavius Martin; Kiran Mukhyala; J Fernando Bazan; Yongmei Chen; Wei Yu Lin; Scott Stawicki; Yan Wu; Melissa A Starovasnik
Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.

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All Publications

2012: Gladys de Leon-Boenig; Christine Everett; Jianwen A Feng; Yvonne Franke; Krista K Bowman; Terry Crawford; Adam R Johnson; Angela Oh; Steven T Staben; Mark Stanley; Melissa A Starovasnik; Heidi J A Wallweber; Jiansheng Wu; Lawren C Wu; Sarah G Hymowitz
The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.
Structure (London, England : 1993) 2012;20(10):1704-14.
2012: Xiaolei Ma; Qui T Phung; Clifford L Quan; Melissa A Starovasnik; Krista K Bowman; Elizabeth Helgason; Rekha S Iyer; Michelle W Lee; Erin C Dueber
Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(24):9378-83.
2012: Xiaolei Ma; Flavius Martin; Kiran Mukhyala; J Fernando Bazan; Yongmei Chen; Wei Yu Lin; Scott Stawicki; Yan Wu; Melissa A Starovasnik
Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.
Structure (London, England : 1993) 2012;20(4):676-87.
2012: Till Maurer; Ira Mellman; Angela Oh; Borlan Pan; Keith Pitts; Joachim Rudolph; Nicholas J Skelton; Melissa A Starovasnik; David Stokoe; Weiru Wang; Jiansheng Wu; Benjamin P Fauber; Lindsay S Garrenton; Anthony M Giannetti; Peter K Jackson; Mary J C Ludlam; Shiva Malek; Daniel J Anderson; Krista K Bowman; Guowei Fang
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):5299-304.
2012: Oscar W Huang; Sarah G Hymowitz; Nobuhiko Kayagaki; Xiaolei Ma; Till Maurer; Qui T Phung; Melissa A Starovasnik; JianPing Yin; David Arnott; Ivan Bosanac; Vishva M Dixit; Jeremy Flinders; Andrea G Cochran
Phosphorylation-dependent activity of the deubiquitinase DUBA.
Nature structural & molecular biology 2012;19(2):171-5.
2010: Nathaniel C Gordon; Samantha Lien; Jeremy Johnson; Heidi J A Wallweber; Thuy Tran; Bridget Currell; Mary Mathieu; Clifford Quan; Melissa A Starovasnik; Sarah G Hymowitz; Robert F Kelley
Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display.
Journal of molecular biology 2010;396(1):166-77.
2009: Yik Andy Yeung; Maya K Leabman; Jonathan S Marvin; Julia Qiu; Camellia W Adams; Samantha Lien; Melissa A Starovasnik; Henry B Lowman
Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7663-71.
2007: Wei Yu Lin; Qian Gong; Dhaya Seshasayee; Zhonghua Lin; Qinglin Ou; Shiming Ye; Eric Suto; Jean Shu; Wyne P Lee; Ching-Wei V Lee; Germaine Fuh; Maya Leabman; Suhasini Iyer; Kathy Howell; Thomas Gelzleichter; Joseph Beyer; Dimitry M Danilenko; Sherry Yeh; Laura E DeForge; Allen Ebens; Jeffrey S Thompson; Christine Ambrose; Margit Balazs; Melissa A Starovasnik; Flavius Martin
Anti-BR3 antibodies: a new class of B-cell immunotherapy combining cellular depletion and survival blockade.
Blood 2007;110(12):3959-67.
2006: Chingwei V Lee; Sarah G Hymowitz; Heidi J A Wallweber; Nathaniel C Gordon; Karen L Billeci; Siao Ping Tsai; Deanne M Compaan; Jianping Yin; Qian Gong; Robert F Kelley; Laura E DeForge; Flavius Martin; Melissa A Starovasnik; Germaine Fuh
Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
Blood 2006;108(9):3103-11.
2005: Sarah G Hymowitz; Darshana R Patel; Heidi J A Wallweber; Steven Runyon; Minhong Yan; Jianping Yin; Stephanie Shriver; Nathaniel C Gordon; Borlan Pan; Nicholas J Skelton; Robert F Kelley; Melissa A Starovasnik
Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.
The Journal of biological chemistry 2005;280(8):7218-27.
2004: Heidi J A Wallweber; Deanne M Compaan; Melissa A Starovasnik; Sarah G Hymowitz
The crystal structure of a proliferation-inducing ligand, APRIL.
Journal of molecular biology 2004;343(2):283-90.
2004: Jennifer Stamos; Charles Eigenbrot; Gerald R Nakamura; Mark E Reynolds; JianPing Yin; Henry B Lowman; Wayne J Fairbrother; Melissa A Starovasnik
Convergent recognition of the IgE binding site on the high-affinity IgE receptor.
Structure (London, England : 1993) 2004;12(7):1289-301.
2004: Darshana R Patel; Heidi J A Wallweber; JianPing Yin; Stephanie Shriver; Scot A Marsters; Nathaniel C Gordon; Melissa A Starovasnik; Robert F Kelley
Engineering an APRIL-specific B cell maturation antigen.
The Journal of biological chemistry 2004;279(16):16727-35.
2003: Sarah G Hymowitz; Deanne M Compaan; Minhong Yan; Heidi J A Wallweber; Xiaodong Huang; Melissa A Starovasnik; Abraham M de Vos
The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity.
Structure (London, England : 1993) 2003;11(12):1513-20.
2003: Nathaniel C Gordon; Borlan Pan; Sarah G Hymowitz; JianPing Yin; Robert F Kelley; Andrea G Cochran; Minhong Yan; Xiaodong Huang; Wayne J Fairbrother; Melissa A Starovasnik
BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.
Biochemistry 2003;42(20):5977-83.
2002: Nobuhiko Kayagaki; Minhong Yan; Dhaya Seshasayee; Hua Wang; Wyne Lee; Dorothy M French; Iqbal Grewal; Andrea G Cochran; Nathaniel C Gordon; JianPing Yin; Melissa A Starovasnik; Xiaodong Huang
BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.
Immunity 2002;17(4):515-24.
2002: Xiaoqing Sun; Jianping Yin; Melissa A Starovasnik; Wayne J Fairbrother; Xiaodong Huang
Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.
The Journal of biological chemistry 2002;277(11):9505-11.
2002: Gerald R Nakamura; Mark E Reynolds; Yvonne M Chen; Melissa A Starovasnik; Henry B Lowman
Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1303-8.
2001: Liping Cai; Jian Ping Yin; Melissa A Starovasnik; Deborah A Hogue; Kenneth J Hillan; J S Mort; Ellen H Filvaroff
Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo.
Cytokine 2001;16(1):10-21.
2001: Sarah G Hymowitz; Ellen H Filvaroff; Jian Ping Yin; Asuka Morimoto; Liping Cai; P Risser; M Maruoka; Weiguang Mao; Jessica Foster; Robert F Kelley; Guohua Pan; Austin Gurney; Abraham M de Vos; Melissa A Starovasnik
IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
The EMBO journal 2001;20(19):5332-41.
2001: Wayne J Fairbrother; Nathaniel C Gordon; EW Humke; Karen M O'Rourke; Melissa A Starovasnik; Jian Ping Yin; Xiaodong Huang
The PYRIN domain: a member of the death domain-fold superfamily.
Protein science : a publication of the Protein Society 2001;10(9):1911-8.
2001: Gerald R Nakamura; Melissa A Starovasnik; Mark E Reynolds; Henry B Lowman
A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor.
Biochemistry 2001;40(33):9828-35.
2001: Andrea G Cochran; Nicholas J Skelton; Melissa A Starovasnik
Tryptophan zippers: stable, monomeric beta -hairpins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5578-83.
2001: Andrea G Cochran; R T Tong; Melissa A Starovasnik; E J Park; Robert S McDowell; J E Theaker; Nicholas J Skelton
A minimal peptide scaffold for beta-turn display: optimizing a strand position in disulfide-cyclized beta-hairpins.
Journal of the American Chemical Society 2001;123(4):625-32.
2000: EW Humke; Stephanie Shriver; Melissa A Starovasnik; Wayne J Fairbrother; Xiaodong Huang
ICEBERG: a novel inhibitor of interleukin-1beta generation.
Cell 2000;103(1):99-111.
2000: D P Meininger; M Rance; Melissa A Starovasnik; Wayne J Fairbrother; Nicholas J Skelton
Characterization of the binding interface between the E-domain of Staphylococcal protein A and an antibody Fv-fragment.
Biochemistry 2000;39(1):26-36.
1999: Melissa A Starovasnik; Hans W Christinger; Christian Wiesmann; MA Champe; Abraham M de Vos; Nicholas J Skelton
Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
Journal of molecular biology 1999;293(3):531-44.
1999: Melissa A Starovasnik; MP O'Connell; Wayne J Fairbrother; Robert F Kelley
Antibody variable region binding by Staphylococcal protein A: thermodynamic analysis and location of the Fv binding site on E-domain.
Protein science : a publication of the Protein Society 1999;8(7):1423-31.
1999: Y H Kao; Geoffrey F Lee; Y Wang; Melissa A Starovasnik; Robert F Kelley; M W Spellman; L Lerner
The effect of O-fucosylation on the first EGF-like domain from human blood coagulation factor VII.
Biochemistry 1999;38(22):7097-110.
1998: Wayne J Fairbrother; MA Champe; Hans W Christinger; BA Keyt; Melissa A Starovasnik
Solution structure of the heparin-binding domain of vascular endothelial growth factor.
Structure (London, England : 1993) 1998;6(5):637-48.
1997: Wayne J Fairbrother; MA Champe; Hans W Christinger; BA Keyt; Melissa A Starovasnik
1H, 13C, and 15N backbone assignment and secondary structure of the receptor-binding domain of vascular endothelial growth factor.
Protein science : a publication of the Protein Society 1997;6(10):2250-60.
1997: Melissa A Starovasnik; Andrew C Braisted; James A Wells
Structural mimicry of a native protein by a minimized binding domain.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10080-5.
1996: Melissa A Starovasnik; Nicholas J Skelton; MP O'Connell; Robert F Kelley; D Reilly; Wayne J Fairbrother
Solution structure of the E-domain of staphylococcal protein A.
Biochemistry 1996;35(48):15558-69.