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Jeff Staudinger

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Jeff L Staudinger; Mengxi Sun; Sarah Woody; Wenqi Cui
Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver.
Heather Hajovsky; Wenqi Cui; Gang Hu; Yakov M Koen; David S Moore; Diganta Sarma; Jeff L Staudinger; Robert P Hanzlik
Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes.
Diganta Sarma; Jeff L Staudinger; Todd D Williams; Nadezhda A Galeva; Heather Hajovsky; Yakov M Koen; Robert P Hanzlik
Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites.

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All Publications

2013: Jeff L Staudinger; Mengxi Sun; Sarah Woody; Wenqi Cui
Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver.
Drug metabolism reviews 2013;45(1):48-59.
2012: Heather Hajovsky; Wenqi Cui; Gang Hu; Yakov M Koen; David S Moore; Diganta Sarma; Jeff L Staudinger; Robert P Hanzlik
Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes.
Chemical research in toxicology 2012;25(9):1955-63.
2012: Diganta Sarma; Jeff L Staudinger; Todd D Williams; Nadezhda A Galeva; Heather Hajovsky; Yakov M Koen; Robert P Hanzlik
Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites.
Chemical research in toxicology 2012;25(9):1868-77.
2011: Jeff L Staudinger; Chenshu Xu; Arunima Biswas; Sridhar Mani
Post-translational modification of pregnane x receptor.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;64(1):4-10.
2010: Gang Hu; Chenshu Xu; Jeff L Staudinger
Pregnane X receptor is SUMOylated to repress the inflammatory response.
The Journal of pharmacology and experimental therapeutics 2010;335(2):342-50.
2010: Jeff L Staudinger; Chenshu Xu; Yue J Cui; Curtis D Klaassen
Nuclear receptor-mediated regulation of carboxylesterase expression and activity.
Expert opinion on drug metabolism & toxicology 2010;6(3):261-71.
2009: Kristin Lichti-Kaiser; Dan Brobst; Chenshu Xu; Jeff L Staudinger
A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.
The Journal of pharmacology and experimental therapeutics 2009;331(1):65-76.
2009: Chenshu Xu; Xinkun Wang; Jeff L Staudinger
Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(7):1539-47.
2009: Rakesh K Singh; Ying Dai; Jeff L Staudinger; Nancy A Muma
Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, clozapine and MDL 100907.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(5):651-65.
2009: Kristin Lichti-Kaiser; Chenshu Xu; Jeff L Staudinger
Cyclic AMP-dependent protein kinase signaling modulates pregnane x receptor activity in a species-specific manner.
The Journal of biological chemistry 2009;284(11):6639-49.
2008: Kristin Lichti-Kaiser; Jeff L Staudinger
The traditional Chinese herbal remedy tian xian activates pregnane X receptor and induces CYP3A gene expression in hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(8):1538-45.
2008: Jeff L Staudinger; Kristin Lichti
Cell signaling and nuclear receptors: new opportunities for molecular pharmaceuticals in liver disease.
Molecular pharmaceutics 2008;5(1):17-34.
2006: Jeff L Staudinger; Xunshan Ding; Kristin Lichti
Pregnane X receptor and natural products: beyond drug-drug interactions.
Expert opinion on drug metabolism & toxicology 2006;2(6):847-57.
2006: Xunshan Ding; Kristin Lichti; Insook Kim; Frank J Gonzalez; Jeff L Staudinger
Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha.
The Journal of biological chemistry 2006;281(36):26540-51.
2006: Xunshan Ding; Kristin Lichti; Jeff L Staudinger
The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor.
Toxicological sciences : an official journal of the Society of Toxicology 2006;91(2):448-55.
2005: Xunshan Ding; Jeff L Staudinger
The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter.
The Journal of pharmacology and experimental therapeutics 2005;314(1):120-7.
2005: Xunshan Ding; Jeff L Staudinger
Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C.
Biochemical pharmacology 2005;69(5):867-73.
2005: Xunshan Ding; Jeff L Staudinger
Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway.
The Journal of pharmacology and experimental therapeutics 2005;312(2):849-56.
2004: Dan E Brobst; Xunshan Ding; Katrina L Creech; Bryan Goodwin; Brian Kelley; Jeff L Staudinger
Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor.
The Journal of pharmacology and experimental therapeutics 2004;310(2):528-35.
2003: Chuan Chen; Jeff L Staudinger; Curtis D Klaassen
Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(7):908-15.
2003: Jeff L Staudinger; Ajay Madan; Kathleen M Carol; Andrew Parkinson
Regulation of drug transporter gene expression by nuclear receptors.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(5):523-7.
2002: Grace L Guo; Jeff L Staudinger; Kenichiro Ogura; Curtis D Klaassen
Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor.
Molecular pharmacology 2002;61(4):832-9.
2001: Jeff L Staudinger; Yaping Liu; Ajay Madan; Sultan S M Habeebu; Curtis D Klaassen
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1467-72.
2001: Jeff L Staudinger; Bryan Goodwin; Stacey A Jones; D Hawkins-Brown; K I MacKenzie; Anne M Latour; Yaping Liu; Curtis D Klaassen; K K Brown; J Reinhard; Timothy M Willson; Beverly H Koller; Steven A Kliewer
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3369-74.
1998: Steven A Kliewer; John T Moore; L Wade; Jeff L Staudinger; Michael A Watson; Stacey A Jones; David D McKee; BB Oliver; Timothy M Willson; R H Zetterström; Thomas Perlmann; Jurgen Lehmann
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.
Cell 1998;92(1):73-82.