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Matthias Staufenbiel

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Ajeet Rijal Upadhaya; Matthias Staufenbiel; Jochen Walter; Haruyasu Yamaguchi; Dorothee Abramowski; Estibaliz Capetillo-Zarate; Marcus Fändrich; Irina Kosterin; Sathish Kumar; Dietmar R Thal
Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice.
Bengt Winblad; Niels Andreasen; Kaj Blennow; Thomas Dumortier; Annette Floesser; Georges Imbert; Joens Lundmark; R Paul Maguire; Lennart Minthon; Jean-Marc Orgogozo; Matthias Staufenbiel; Ana Graf
Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study.
Marc Aurel Busche; Xiaowei Chen; Horst A Henning; Julia Reichwald; Bert Sakmann; Matthias Staufenbiel; Arthur Konnerth
Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease.

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2012: Ajeet Rijal Upadhaya; Matthias Staufenbiel; Jochen Walter; Haruyasu Yamaguchi; Dorothee Abramowski; Estibaliz Capetillo-Zarate; Marcus Fändrich; Irina Kosterin; Sathish Kumar; Dietmar R Thal
Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice.
Neurobiology of aging 2012;33(11):2641-60.
2012: Bengt Winblad; Niels Andreasen; Kaj Blennow; Thomas Dumortier; Annette Floesser; Georges Imbert; Joens Lundmark; R Paul Maguire; Lennart Minthon; Jean-Marc Orgogozo; Matthias Staufenbiel; Ana Graf
Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study.
Lancet neurology 2012;11(7):597-604.
2012: Marc Aurel Busche; Xiaowei Chen; Horst A Henning; Julia Reichwald; Bert Sakmann; Matthias Staufenbiel; Arthur Konnerth
Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(22):8740-5.
2012: Heinrich Rueeger; Matthias Staufenbiel; Olivier Rogel; Jean-Michel Rondeau; Sandrine Desrayaud; Laura Jacobson; Rainer Lueoend; Rainer Machauer; Henrik Möbitz; Ulf Neumann
Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides.
Journal of medicinal chemistry 2012;55(7):3364-86.
2012: Makoto Higuchi; Nobuhisa Iwata; Bin Ji; Jun Maeda; Yukio Matsuba; Maiko Ono; Matthias Staufenbiel; Takahiro Suemoto; Tetsuya Suhara; Jiro Takano; Takaomi C Saido
Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(3):1204-17.
2012: Dorothee Abramowski; Estibaliz Capetillo-Zarate; Simone Danner; Sabine Rabe; Julia Reichwald; Takaomi C Saido; Dieter Staab; Dietmar R Thal; Ajeet Rijal Upadhaya; Karl-Heinz Wiederhold; Haruyasu Yamaguchi; Matthias Staufenbiel
Transgenic expression of intraneuronal Aβ42 but not Aβ40 leads to cellular Aβ lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(4):1273-83.
2012: Christine Grienberger; Horst A Henning; Daniel N Hill; Julia Reichwald; Nathalie L Rochefort; Matthias Staufenbiel; Helmuth Adelsberger; Arthur Konnerth
Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease.
Nature communications 2012;3():774.
2011: Franziska Langer; Matthias Staufenbiel; Lary C Walker; Yvonne S Eisele; Sarah K Fritschi; Mathias Jucker
Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(41):14488-95.
2011: Heinke Schieb; Matthias Staufenbiel; Jens Wiltfang; Olaf Jahn; Hartmut Kratzin; Wiebke Möbius; Sabine Rabe; Hans-Wolfgang Klafki
Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid.
The Journal of biological chemistry 2011;286(39):33747-58.
2011: Christoph Wiessner; Mauro Zurini; Alain C Tissot; Karl-Heinz Wiederhold; Martin F Bachmann; Simone Danner; Peter Frey; Laura H Jacobson; Gary T Jennings; Rainer Lüönd; Anis Mir; Rainer Ortmann; Julia Reichwald; Matthias Staufenbiel
The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(25):9323-31.
2011: Jun Maeda; Ming-Rong Zhang; Takashi Okauchi; Bin Ji; Maiko Ono; Satoko Hattori; Katsushi Kumata; Nobuhisa Iwata; Takaomi C Saido; John Q Trojanowski; Virginia M-Y Lee; Matthias Staufenbiel; Takami Tomiyama; Hiroshi Mori; Toshimitsu Fukumura; Tetsuya Suhara; Makoto Higuchi
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(12):4720-30.
2011: Nicolau Beckmann; Christelle Gérard; Dorothee Abramowski; Catherine Cannet; Matthias Staufenbiel
Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparamagnetic iron oxide particles in APP transgenic mouse models of Alzheimer's disease: application to passive Abeta immunotherapy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(3):1023-31.
2010: David T Winkler; Dorothee Abramowski; Simone Danner; Mauro Zurini; Paolo Paganetti; Markus Tolnay; Matthias Staufenbiel
Rapid cerebral amyloid binding by Aβ antibodies infused into β-amyloid precursor protein transgenic mice.
Biological psychiatry 2010;68(10):971-4.
2010: Yvonne S Eisele; Ulrike Obermüller; Götz Heilbronner; Frank Baumann; Stephan A Kaeser; Hartwig Wolburg; Lary Walker; Matthias Staufenbiel; Mathias Heikenwalder; Mathias Jucker
Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.
Science (New York, N.Y.) 2010;330(6006):980-2.
2010: Andreas Lerchner; Rainer Machauer; Claudia Betschart; Siem Veenstra; Heinrich Rueeger; Clive McCarthy; Marina Tintelnot-Blomley; Anne-Lise Jaton; Sabine Rabe; Sandrine Desrayaud; Albert Enz; Matthias Staufenbiel; Paolo Paganetti; Jean-Michel Rondeau; Ulf Neumann
Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
Bioorganic & medicinal chemistry letters 2010;20(2):603-7.
2009: Dietmar R Thal; Estibaliz Capetillo-Zarate; Sergey Larionov; Matthias Staufenbiel; Stefan Zurbruegg; Nicolau Beckmann
Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances.
Neurobiology of aging 2009;30(12):1936-48.
2009: Stefan A Grathwohl; Roland E Kälin; Tristan Bolmont; Stefan Prokop; Georg Winkelmann; Stephan A Kaeser; Jörg Odenthal; Rebecca Radde; Therese Eldh; Sam Gandy; Adriano Aguzzi; Matthias Staufenbiel; Paul Mathews; Hartwig Wolburg; Frank L Heppner; Mathias Jucker
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.
Nature neuroscience 2009;12(11):1361-3.
2009: Yvonne S Eisele; Tristan Bolmont; Mathias Heikenwalder; Franziska Langer; Laura H Jacobson; Zheng-Xin Yan; Klaus Roth; Adriano Aguzzi; Matthias Staufenbiel; Lary Walker; Mathias Jucker
Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12926-31.
2009: Bettina M Wegenast-Braun; Ana Fulgencio Maisch; Daniel Eicke; Rebecca Radde; Martin C Herzig; Matthias Staufenbiel; Mathias Jucker; Michael E Calhoun
Independent effects of intra- and extracellular Abeta on learning-related gene expression.
The American journal of pathology 2009;175(1):271-82.
2009: Florence Clavaguera; Tristan Bolmont; R Anthony Crowther; Dorothee Abramowski; Stephan Frank; Alphonse Probst; Graham Fraser; Anna K Stalder; Martin Beibel; Matthias Staufenbiel; Mathias Jucker; Michel Goedert; Markus Tolnay
Transmission and spreading of tauopathy in transgenic mouse brain.
Nature cell biology 2009;11(7):909-13.
2009: Martin C Herzig; Yvonne S Eisele; Matthias Staufenbiel; Mathias Jucker
E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition.
The American journal of pathology 2009;174(3):722-6.
2009: Rainer Machauer; Kurt Laumen; Siem Veenstra; Jean-Michel Rondeau; Marina Tintelnot-Blomley; Claudia Betschart; Anne-Lise Jaton; Sandrine Desrayaud; Matthias Staufenbiel; Sabine Rabe; Paolo Paganetti; Ulf Neumann
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.
Bioorganic & medicinal chemistry letters 2009;19(5):1366-70.
2009: Julia Reichwald; Simone Danner; Karl-Heinz Wiederhold; Matthias Staufenbiel
Expression of complement system components during aging and amyloid deposition in APP transgenic mice.
Journal of neuroinflammation 2009;6():35.
2009: Iliya Lefterov; Nicholas F Fitz; Andrea Cronican; Preslav Lefterov; Matthias Staufenbiel; Radosveta P Koldamova
Memory deficits in APP23/Abca1+/- mice correlate with the level of Aβ oligomers.
ASN neuro 2009;1(2):.
2008: Yann Senechal; Laetitia Prut; Peter Kelly; Matthias Staufenbiel; Francois Natt; Daniel Hoyer; Christoph Wiessner; Kumlesh K Dev
Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA.
Brain research 2008;1243():124-33.
2008: Hong Qing; Guiqiong He; Philip T T Ly; Christopher J Fox; Matthias Staufenbiel; Fang Cai; Zhuohua Zhang; Shengcai Wei; Xiulian Sun; Chia-Hsiung Chen; Weihui Zhou; Ke Wang; Weihong Song
Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models.
The Journal of experimental medicine 2008;205(12):2781-9.
2008: Bin Ji; Jun Maeda; Makoto Sawada; Maiko Ono; Takashi Okauchi; Motoki Inaji; Ming-Rong Zhang; Kazutoshi Suzuki; Kiyoshi Ando; Matthias Staufenbiel; John Q Trojanowski; Virginia M-Y Lee; Makoto Higuchi; Tetsuya Suhara
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12255-67.
2008: Dorothee Abramowski; Karl-Heinz Wiederhold; Ulrich Furrer; Anne-Lise Jaton; Anton Neuenschwander; Marie-Josephine Runser; Simone Danner; Julia Reichwald; Domenico Ammaturo; Dieter Staab; Markus Stoeckli; Heinrich Rueeger; Ulf Neumann; Matthias Staufenbiel
Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.
The Journal of pharmacology and experimental therapeutics 2008;327(2):411-24.
2008: Marc Aurel Busche; Gerhard Eichhoff; Helmuth Adelsberger; Dorothee Abramowski; Karl-Heinz Wiederhold; Christian Haass; Matthias Staufenbiel; Arthur Konnerth; Olga Garaschuk
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.
Science (New York, N.Y.) 2008;321(5896):1686-9.
2008: Olaf Schulte-Herbrüggen; S Eckart; U Deicke; Anja A Kühl; U Otten; Heidi Danker-Hopfe; D Abramowski; Matthias Staufenbiel; Rainer Hellweg
Age-dependent time course of cerebral brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 in APP23 transgenic mice.
Journal of neuroscience research 2008;86(12):2774-83.
2008: Annemie Van Dijck; Ellen Vloeberghs; Debby Van Dam; Matthias Staufenbiel; Peter Paul De Deyn
Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory.
Behavioural brain research 2008;190(1):147-51.
2008: Ellen Vloeberghs; Debby Van Dam; Frieda Franck; Jan Serroyen; Molenberghs Geert; Matthias Staufenbiel; Peter Paul De Deyn
Altered ingestive behavior, weight changes, and intact olfactory sense in an APP overexpression model.
Behavioral neuroscience 2008;122(3):491-7.
2008: Florian V Ermini; Stefan Grathwohl; Rebecca Radde; Masohiro Yamaguchi; Matthias Staufenbiel; Theo D Palmer; Mathias Jucker
Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis.
The American journal of pathology 2008;172(6):1520-8.
2008: Eric P Meyer; Alexandra Ulmann-Schuler; Matthias Staufenbiel; Thomas Krucker
Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3587-92.
2008: Nelson Guerreiro; Matthias Staufenbiel; Baltazar Gomez-Mancilla
Proteomic 2-D DIGE profiling of APP23 transgenic mice brain from pre-plaque and plaque phenotypes.
Journal of Alzheimer's disease : JAD 2008;13(1):17-30.
2008: Daniela Hartl; Michael Rohe; Lei Mao; Matthias Staufenbiel; Zabel Claus; Joachim Klose
Impairment of adolescent hippocampal plasticity in a mouse model for Alzheimer's disease precedes disease phenotype.
PloS one 2008;3(7):e2759.
2007: Tristan Bolmont; Florence Clavaguera; Melanie Meyer-Luehmann; Martin C Herzig; Rebecca Radde; Matthias Staufenbiel; Jada Lewis; Michael Hutton; Markus Tolnay; Mathias Jucker
Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice.
The American journal of pathology 2007;171(6):2012-20.
2007: Stephan A Kaeser; Martin C Herzig; Janaky Coomaraswamy; Ellen Kilger; Maj-Linda Bardyl Selenica; David T Winkler; Matthias Staufenbiel; Efrat Levy; Anders Grubb; Mathias Jucker
Cystatin C modulates cerebral beta-amyloidosis.
Nature genetics 2007;39(12):1437-9.
2007: Jun Maeda; Bin Ji; Toshiaki Irie; Takami Tomiyama; Masahiro Maruyama; Takashi Okauchi; Matthias Staufenbiel; Nobuhisa Iwata; Maiko Ono; Takaomi C Saido; Kazutoshi Suzuki; Hiroshi Mori; Makoto Higuchi; Tetsuya Suhara
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(41):10957-68.
2007: Ping He; Zhenyu Zhong; Kristina Lindholm; Lilian Berning; Wendy Lee; Cynthia A Lemere; Matthias Staufenbiel; Rena Li; Yong Shen
Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice.
The Journal of cell biology 2007;178(5):829-41.
2007: Dietmar R Thal; Sergey Larionov; Dorothee Abramowski; Karl-Heinz Wiederhold; Tom Van Dooren; Haruyasu Yamaguchi; Christian Haass; Fred Van Leuven; Matthias Staufenbiel; Estibaliz Capetillo-Zarate
Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice.
Neurobiology of aging 2007;28(8):1221-30.
2007: Ellen Vloeberghs; Debby Van Dam; Frieda Franck; Matthias Staufenbiel; Peter Paul De Deyn
Mood and male sexual behaviour in the APP23 model of Alzheimer's disease.
Behavioural brain research 2007;180(2):146-51.
2007: L Prut; Dorothee Abramowski; Thomas Krucker; Coree L Levy; A J Roberts; Matthias Staufenbiel; Christoph Wiessner
Aged APP23 mice show a delay in switching to the use of a strategy in the Barnes maze.
Behavioural brain research 2007;179(1):107-10.
2007: Guido J Burbach; Andreas Vlachos; Estifanos Ghebremedhin; Domenico Del Turco; Janaky Coomaraswamy; Matthias Staufenbiel; Mathias Jucker; Thomas Deller
Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage.
Neurobiology of aging 2007;28(2):202-12.
2007: Iliya Lefterov; Angie Bookout; Zhu Wang; Matthias Staufenbiel; David Mangelsdorf; Radosveta P Koldamova
Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment.
Molecular neurodegeneration 2007;2():20.
2007: Martin C Herzig; Paolo Paganetti; Matthias Staufenbiel; Mathias Jucker
BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice.
Neuro-degenerative diseases 2007;4(2-3):127-35.
2006: Susanne Wolf; Golo Kronenberg; Kathrin Lehmann; Aaron Blankenship; Rupert W Overall; Matthias Staufenbiel; Gerd Kempermann
Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease.
Biological psychiatry 2006;60(12):1314-23.
2006: Xiulian Sun; Guiqiong He; Hong Qing; Weihui Zhou; Frederick Dobie; Fang Cai; Matthias Staufenbiel; L Eric Huang; Weihong Song
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(49):18727-32.
2006: Ellen Vloeberghs; Debby Van Dam; Katrien Coen; Matthias Staufenbiel; Peter Paul De Deyn
Aggressive male APP23 mice modeling behavioral alterations in dementia.
Behavioral neuroscience 2006;120(6):1380-3.
2006: Hans-Wolfgang Klafki; Matthias Staufenbiel; Johannes Kornhuber; Jens Wiltfang
Therapeutic approaches to Alzheimer's disease.
Brain : a journal of neurology 2006;129(Pt 11):2840-55.
2006: Estibaliz Capetillo-Zarate; Matthias Staufenbiel; Dorothee Abramowski; Christian Haass; Angelika Escher; Christine Stadelmann; Haruyasu Yamaguchi; Otmar D Wiestler; Dietmar R Thal
Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology.
Brain : a journal of neurology 2006;129(Pt 11):2992-3005.
2006: Ellen Vloeberghs; Debby Van Dam; Rudi D'Hooge; Matthias Staufenbiel; Peter Paul De Deyn
APP23 mice display working memory impairment in the plus-shaped water maze.
Neuroscience letters 2006;407(1):6-10.
2006: Melanie Meyer-Luehmann; Janaky Coomaraswamy; Tristan Bolmont; Stephan A Kaeser; Claudia Schaefer; Ellen Kilger; Anton Neuenschwander; Dorothee Abramowski; Peter Frey; Anneliese L Jaton; Jean-Marie Vigouret; Paolo Paganetti; Dominic M Walsh; Paul Mathews; Jorge Ghiso; Matthias Staufenbiel; Lary Walker; Mathias Jucker
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
Science (New York, N.Y.) 2006;313(5794):1781-4.
2006: Shu-Ming Huang; Akihiro Mouri; Hideko Kokubo; Ryuichi Nakajima; Takahiro Suemoto; Makoto Higuchi; Matthias Staufenbiel; Yukihiro Noda; Haruyasu Yamaguchi; Toshitaka Nabeshima; Takaomi C Saido; Nobuhisa Iwata
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
The Journal of biological chemistry 2006;281(26):17941-51.
2006: Yoshio Okura; Akira Miyakoshi; Kuniko Kohyama; Il-Kwon Park; Matthias Staufenbiel; Yoh Matsumoto
Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9619-24.
2006: Lorena Heredia; Pablo Helguera; Soledad De Olmos; Gabriela Kedikian; Francisco Solá Vigo; Frank M LaFerla; Matthias Staufenbiel; José de Olmos; Jorge Busciglio; Alfredo Cáceres; Alfredo Lorenzo
Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(24):6533-42.
2006: Michael T Heneka; Mutiah Ramanathan; Andreas H Jacobs; Lucia Dumitrescu-Ozimek; Andras Bilkei-Gorzo; Thomas Debeir; Magdalena Sastre; Norbert Galldiks; Andreas Zimmer; Mathias Hoehn; Wolf-Dieter Heiss; Thomas Klockgether; Matthias Staufenbiel
Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(5):1343-54.
2005: Radosveta P Koldamova; Matthias Staufenbiel; Iliya Lefterov
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.
The Journal of biological chemistry 2005;280(52):43224-35.
2005: Xu Yue; Melissa Lu; Techie Lancaster; Phillip Cao; Shin-Ichiro Honda; Matthias Staufenbiel; Nobuhiro Harada; Zhenyu Zhong; Yong Shen; Rena Li
Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19198-203.
2005: Anna K Stalder; Florian Ermini; Luca Bondolfi; Werner Krenger; Guido J Burbach; Thomas Deller; Janaky Coomaraswamy; Matthias Staufenbiel; Regine Landmann; Mathias Jucker
Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(48):11125-32.
2005: Debby Van Dam; Dorothee Abramowski; Matthias Staufenbiel; Peter Paul De Deyn
Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model.
Psychopharmacology 2005;180(1):177-90.
2005: Martin Hintersteiner; Albert Enz; Peter Frey; Anne-Lise Jaton; Willy Kinzy; Rainer Kneuer; Ulf Neumann; Markus Rudin; Matthias Staufenbiel; Markus Stoeckli; Karl-Heinz Wiederhold; Hans-Ulrich Gremlich
In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe.
Nature biotechnology 2005;23(5):577-83.
2005: Sonia Boncristiano; Michael E Calhoun; Victor Howard; Luca Bondolfi; Stephan A Kaeser; Karl-Heinz Wiederhold; Matthias Staufenbiel; Mathias Jucker
Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice.
Neurobiology of aging 2005;26(5):607-13.
2005: Debby Van Dam; Bart Marescau; Sebastiaan Engelborghs; Thomas Cremers; Jan Mulder; Matthias Staufenbiel; Peter Paul De Deyn
Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models.
Neurochemistry international 2005;46(5):409-22.
2005: Debby Van Dam; Ellen Vloeberghs; Dorothee Abramowski; Matthias Staufenbiel; Peter Paul P De Deyn
APP23 mice as a model of Alzheimer's disease: an example of a transgenic approach to modeling a CNS disorder.
CNS spectrums 2005;10(3):207-22.
2005: Radosveta P Koldamova; Iliya Lefterov; Matthias Staufenbiel; Darren Wolfe; Shaohua Huang; Joseph C Glorioso; Michael Walter; Michael Roth; John Lazo
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease.
The Journal of biological chemistry 2005;280(6):4079-88.
2005: Robert Lalonde; M Dumont; Matthias Staufenbiel; Catherine Strazielle
Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screen.
Behavioural brain research 2005;157(1):91-8.
2004: Ellen Vloeberghs; Debby Van Dam; Sebastiaan Engelborghs; Guy Nagels; Matthias Staufenbiel; Peter Paul De Deyn
Altered circadian locomotor activity in APP23 mice: a model for BPSD disturbances.
The European journal of neuroscience 2004;20(10):2757-66.
2004: M Dumont; C Strazielle; Matthias Staufenbiel; R Lalonde
Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation.
Brain research 2004;1024(1-2):113-21.
2004: Guido J Burbach; Doris Dehn; Domenico Del Turco; Matthias Staufenbiel; Thomas Deller
Laser microdissection reveals regional and cellular differences in GFAP mRNA upregulation following brain injury, axonal denervation, and amyloid plaque deposition.
Glia 2004;48(1):76-84.
2004: Martin C Herzig; David T Winkler; Patrick Burgermeister; Michelle Pfeifer; Esther Kohler; Stephen D Schmidt; Simone Danner; Dorothee Abramowski; Christine Stürchler-Pierrat; Kurt Bürki; Sjoerd G van Duinen; Marion L C Maat-Schieman; Matthias Staufenbiel; Paul Mathews; Mathias Jucker
Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.
Nature neuroscience 2004;7(9):954-60.
2004: Thomas Mueggler; Melanie Meyer-Luehmann; Martin Rausch; Matthias Staufenbiel; Mathias Jucker; Markus Rudin
Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis.
The European journal of neuroscience 2004;20(3):811-7.
2004: Thomas Krucker; Alexandra Schuler; Eric P Meyer; Matthias Staufenbiel; Nicolau Beckmann
Magnetic resonance angiography and vascular corrosion casting as tools in biomedical research: application to transgenic mice modeling Alzheimer's disease.
Neurological research 2004;26(5):507-16.
2004: Nobuyuki Okamura; Takahiro Suemoto; Hiroshi Shimadzu; Masako Suzuki; Tsuyoshi Shiomitsu; Hiroyasu Akatsu; Takayuki Yamamoto; Matthias Staufenbiel; Kazuhiko Yanai; Hiroyuki Arai; Hidetada Sasaki; Yukitsuka Kudo; Tohru Sawada
Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(10):2535-41.
2004: Guido J Burbach; Rainer Hellweg; Carola A Haas; Domenico Del Turco; Uwe Deicke; Dorothee Abramowski; Mathias Jucker; Matthias Staufenbiel; Thomas Deller
Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(10):2421-30.
2004: Nobuyuki Okamura; Takahiro Suemoto; Tsuyoshi Shiomitsu; Masako Suzuki; Hiroshi Shimadzu; Hiroyasu Akatsu; Takayuki Yamamoto; Hiroyuki Arai; Hidetada Sasaki; Kazuhiko Yanai; Matthias Staufenbiel; Yukitsuka Kudo; Tohru Sawada
A novel imaging probe for in vivo detection of neuritic and diffuse amyloid plaques in the brain.
Journal of molecular neuroscience : MN 2004;24(2):247-55.
2004: Klaus Fassbender; Silke Walter; Sandra Kühl; Regine Landmann; K Ishii; Thomas Bertsch; Anna K Stalder; Frank Muehlhauser; Yang Liu; Artur J Ulmer; Serge Rivest; Arnd Lentschat; E Gulbins; Mathias Jucker; Matthias Staufenbiel; Katrin Brechtel; J Walter; Gerd Multhaup; Botond Penke; Y Adachi; Tobias Hartmann; Konrad Beyreuther
The LPS receptor (CD14) links innate immunity with Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):203-5.
2003: Margarita Diez; Simone Danner; Peter Frey; Bernd Sommer; Matthias Staufenbiel; Karl-Heinz Wiederhold; Tomas Hökfelt
Neuropeptide alterations in the hippocampal formation and cortex of transgenic mice overexpressing beta-amyloid precursor protein (APP) with the Swedish double mutation (APP23).
Neurobiology of disease 2003;14(3):579-94.
2003: Ulrich Gärtner; Martina K Brückner; Sabine Krug; Stefanie Schmetsdorf; Matthias Staufenbiel; Thomas Arendt
Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons.
Acta neuropathologica 2003;106(6):535-44.
2003: Thomas A Bayer; Stephanie Schäfer; Andreas Simons; André Kemmling; Thomas Kamer; Ralf Tepest; Anne Eckert; Katrin Schüssel; Oliver Eikenberg; Christine Sturchler-Pierrat; Dorothee Abramowski; Matthias Staufenbiel; Gerd Multhaup
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14187-92.
2003: Nicolau Beckmann; Alexandra Schuler; Thomas Mueggler; Eric P Meyer; Karl-Heinz Wiederhold; Matthias Staufenbiel; Thomas Krucker
Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8453-9.
2003: Thomas Mueggler; Diana Baumann; Martin Rausch; Matthias Staufenbiel; Markus Rudin
Age-dependent impairment of somatosensory response in the amyloid precursor protein 23 transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(23):8231-6.
2003: Anne M Cataldo; Suzana Petanceska; Corrinne M Peterhoff; Nicole B Terio; Charles J Epstein; Angela Villar; Elaine J Carlson; Matthias Staufenbiel; Ralph A. Nixon
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(17):6788-92.
2003: Melanie Meyer-Luehmann; Martina Stalder; Martin C Herzig; Stephan A Kaeser; Esther Kohler; Michelle Pfeifer; Sonia Boncristiano; Paul Mathews; Marc Mercken; Dorothee Abramowski; Matthias Staufenbiel; Mathias Jucker
Extracellular amyloid formation and associated pathology in neural grafts.
Nature neuroscience 2003;6(4):370-7.
2003: Peter Kelly; Luca Bondolfi; D Hunziker; H-P Schlecht; K Carver; E Maguire; Dorothee Abramowski; Karl-Heinz Wiederhold; Christine Sturchler-Pierrat; Mathias Jucker; R Bergmann; Matthias Staufenbiel; Bernd Sommer
Progressive age-related impairment of cognitive behavior in APP23 transgenic mice.
Neurobiology of aging 2003;24(2):365-78.
2003: Catherine Strazielle; Christine Sturchler-Pierrat; Matthias Staufenbiel; Robert Lalonde
Regional brain cytochrome oxidase activity in beta-amyloid precursor protein transgenic mice with the Swedish mutation.
Neuroscience 2003;118(4):1151-63.
2003: Debby Van Dam; Rudi D'Hooge; Matthias Staufenbiel; Chris Van Ginneken; Frans Van Meir; Peter Paul De Deyn
Age-dependent cognitive decline in the APP23 model precedes amyloid deposition.
The European journal of neuroscience 2003;17(2):388-96.
2002: Markus Stoeckli; Dieter Staab; Matthias Staufenbiel; Karl-Heinz Wiederhold; Luca Signor
Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry.
Analytical biochemistry 2002;311(1):33-9.
2002: Robert Lalonde; M Dumont; Matthias Staufenbiel; Christine Sturchler-Pierrat; Catherine Strazielle
Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation.
Brain research 2002;956(1):36-44.
2002: Michelle Pfeifer; Sonia Boncristiano; Luca Bondolfi; Anna K Stalder; Thomas Deller; Matthias Staufenbiel; Paul Mathews; Mathias Jucker
Cerebral hemorrhage after passive anti-Abeta immunotherapy.
Science (New York, N.Y.) 2002;298(5597):1379.
2002: Thomas Mueggler; Christine Sturchler-Pierrat; Diana Baumann; Martin Rausch; Matthias Staufenbiel; Markus Rudin
Compromised hemodynamic response in amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(16):7218-24.
2002: Dieter Lütjohann; Andreas Brzezinka; Esther Barth; Dorothee Abramowski; Matthias Staufenbiel; Klaus Von Bergmann; Konrad Beyreuther; Gerd Multhaup; Thomas A Bayer
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.
Journal of lipid research 2002;43(7):1078-85.
2002: David T Winkler; Luc Biedermann; Markus Tolnay; Peter R Allegrini; Matthias Staufenbiel; Christoph Wiessner; Mathias Jucker
Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy.
Annals of neurology 2002;51(6):790-3.
2002: Sonia Boncristiano; Michael E Calhoun; Peter Kelly; Michelle Pfeifer; Luca Bondolfi; Martina Stalder; Amie L Phinney; Dorothee Abramowski; Christine Sturchler-Pierrat; Albert Enz; Bernd Sommer; Matthias Staufenbiel; Mathias Jucker
Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(8):3234-43.
2002: Ursula Bodendorf; Simone Danner; Frauke Fischer; Muriel Stefani; Christine Sturchler-Pierrat; Karl-Heinz Wiederhold; Matthias Staufenbiel; Paolo Paganetti
Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.
Journal of neurochemistry 2002;80(5):799-806.
2002: Walter Kalback; M Desiree Watson; Tyler A Kokjohn; Yu-Min Kuo; Nicole Weiss; Dean C Luehrs; John Lopez; Daniel C Brune; Sangram S Sisodia; Matthias Staufenbiel; Mark Emmerling; Alex Roher
APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
Biochemistry 2002;41(3):922-8.
2002: Luca Bondolfi; Michael E Calhoun; Florian Ermini; H Georg Kuhn; Karl-Heinz Wiederhold; Lary Walker; Matthias Staufenbiel; Mathias Jucker
Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(2):515-22.
2002: Maren Büchner; Roman Huber; Christine Sturchler-Pierrat; Matthias Staufenbiel; Matthias W Riepe
Impaired hypoxic tolerance and altered protein binding of NADH in presymptomatic APP23 transgenic mice.
Neuroscience 2002;114(2):285-9.
2001: Hans-Joachim Lüth; Max Holzer; Ulrich Gärtner; Matthias Staufenbiel; Thomas Arendt
Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology.
Brain research 2001;913(1):57-67.
2001: Yu-Min Kuo; Thomas Beach; Lucia I Sue; Sarah Scott; Kathryn Layne; Tyler A Kokjohn; Walter Kalback; Dean C Luehrs; T A Vishnivetskaya; Dorothee Abramowski; Christine Sturchler-Pierrat; Matthias Staufenbiel; Roy O Weller; Alex Roher
The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease.
Molecular medicine (Cambridge, Mass.) 2001;7(9):609-18.
2001: Martina Stalder; Thomas Deller; Matthias Staufenbiel; Mathias Jucker
3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: no evidence of intracellular amyloid.
Neurobiology of aging 2001;22(3):427-34.
2001: Yu-Min Kuo; Tyler A Kokjohn; Thomas Beach; Lucia I Sue; Daniel C Brune; J C Lopez; Walter Kalback; Dorothee Abramowski; Christine Sturchler-Pierrat; Matthias Staufenbiel; Alex Roher
Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains.
The Journal of biological chemistry 2001;276(16):12991-8.
2001: David T Winkler; Luca Bondolfi; Martin C Herzig; L Jann; Michael E Calhoun; Karl-Heinz Wiederhold; Markus Tolnay; Matthias Staufenbiel; Mathias Jucker
Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(5):1619-27.
2001: K D Bornemann; Karl-Heinz Wiederhold; C Pauli; Florian Ermini; Martina Stalder; L Schnell; Bernd Sommer; Mathias Jucker; Matthias Staufenbiel
Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice.
The American journal of pathology 2001;158(1):63-73.
2000: K D Bornemann; Matthias Staufenbiel
Transgenic mouse models of Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;908():260-6.
2000: Alfredo Lorenzo; M Yuan; Zhuohua Zhang; Paolo Paganetti; Christine Sturchler-Pierrat; Matthias Staufenbiel; J Mautino; F S Vigo; Bernd Sommer; Bruce A Yankner
Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.
Nature neuroscience 2000;3(5):460-4.
2000: Christine Sturchler-Pierrat; Matthias Staufenbiel
Pathogenic mechanisms of Alzheimer's disease analyzed in the APP23 transgenic mouse model.
Annals of the New York Academy of Sciences 2000;920():134-9.
2000: Bernd Sommer; Christine Sturchler-Pierrat; Dorothee Abramowski; Karl-Heinz Wiederhold; Michael E Calhoun; Mathias Jucker; P Kelly; Matthias Staufenbiel
Transgenic approaches to model Alzheimer's disease.
Reviews in the neurosciences 2000;11(1):47-51.
1999: Michael E Calhoun; Patrick Burgermeister; Amie L Phinney; Martina Stalder; Markus Tolnay; Karl-Heinz Wiederhold; Dorothee Abramowski; Christine Sturchler-Pierrat; Bernd Sommer; Matthias Staufenbiel; Mathias Jucker
Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):14088-93.
1999: Amie L Phinney; Thomas Deller; Martina Stalder; Michael E Calhoun; Michael Frotscher; Bernd Sommer; Matthias Staufenbiel; Mathias Jucker
Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(19):8552-9.
1999: Martina Stalder; Amie L Phinney; Alphonse Probst; Bernd Sommer; Matthias Staufenbiel; Mathias Jucker
Association of microglia with amyloid plaques in brains of APP23 transgenic mice.
The American journal of pathology 1999;154(6):1673-84.
1998: Michael E Calhoun; Karl-Heinz Wiederhold; Dorothee Abramowski; Amie L Phinney; Alphonse Probst; Christine Sturchler-Pierrat; Matthias Staufenbiel; Bernd Sommer; Mathias Jucker
Neuron loss in APP transgenic mice.
Nature 1998;395(6704):755-6.
1998: Zhuohua Zhang; H Hartmann; V M Do; Dorothee Abramowski; Christine Sturchler-Pierrat; Matthias Staufenbiel; Bernd Sommer; M van de Wetering; H Clevers; P Saftig; Bart De Strooper; X He; Bruce A Yankner
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.
Nature 1998;395(6703):698-702.
1998: B Legutko; Matthias Staufenbiel; K Krieglstein
Amyloid beta peptide is not a candidate for the neurotrophic activities released from chromaffin cells.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1998;16(5):347-52.
1998: B Sommer; Matthias Staufenbiel
A beta peptide deposition in the brains of transgenic mice: evidence for a key event in Alzheimer's disease pathogenesis.
Molecular psychiatry 1998;3(4):284-6, 282-3.
1997: Christine Sturchler-Pierrat; Dorothee Abramowski; M Duke; Karl-Heinz Wiederhold; C Mistl; S Rothacher; Birgit Ledermann; Kurt Bürki; Peter Frey; Paolo Paganetti; C Waridel; Michael E Calhoun; Mathias Jucker; Alphonse Probst; Matthias Staufenbiel; Bernd Sommer
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13287-92.
1997: Matthias Staufenbiel; E Pombo-Villar
[Genetic predisposition to Alzheimer's disease].
Revista de neurologia 1997;25(144):1285-8.
1997: Jorge Busciglio; H Hartmann; Alfredo Lorenzo; C Wong; KH Baumann; Bernd Sommer; Matthias Staufenbiel; Bruce A Yankner
Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(13):5101-7.
1997: H Hartmann; Jorge Busciglio; KH Baumann; Matthias Staufenbiel; Bruce A Yankner
Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation.
The Journal of biological chemistry 1997;272(23):14505-8.
1997: G Schrader-Fischer; Matthias Staufenbiel; Paolo Paganetti
Insertion of lysosomal targeting sequences to the amyloid precursor protein reduces secretion of beta A4.
Journal of neurochemistry 1997;68(4):1571-80.
1997: KH Baumann; Paolo Paganetti; Christine Sturchler-Pierrat; C Wong; H Hartmann; R Cescato; Peter Frey; Bruce A Yankner; Bernd Sommer; Matthias Staufenbiel
Distinct processing of endogenous and overexpressed recombinant presenilin 1.
Neurobiology of aging 1997;18(2):181-9.
1997: Jens Wiltfang; Alexandr Smirnov; B Schnierstein; G Kelemen; U Matthies; Hans-Wolfgang Klafki; Matthias Staufenbiel; Gerald Hüther; Eckart Rüther; Johannes Kornhuber
Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.
Electrophoresis 1997;18(3-4):527-32.
1996: H Klafki; Dorothee Abramowski; R Swoboda; Paolo Paganetti; Matthias Staufenbiel
The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities.
The Journal of biological chemistry 1996;271(45):28655-9.
1996: Paolo Paganetti; M Lis; H W Klafki; Matthias Staufenbiel
Amyloid precursor protein truncated at any of the gamma-secretase sites is not cleaved to beta-amyloid.
Journal of neuroscience research 1996;46(3):283-93.
1996: H W Klafki; J Wiltfang; Matthias Staufenbiel
Electrophoretic separation of betaA4 peptides (1-40) and (1-42).
Analytical biochemistry 1996;237(1):24-9.
1996: K Andrä; Dorothee Abramowski; M Duke; Alphonse Probst; Karl-Heinz Wiederhold; K Bürki; Michel Goedert; Bernd Sommer; Matthias Staufenbiel
Expression of APP in transgenic mice: a comparison of neuron-specific promoters.
Neurobiology of aging 1996;17(2):183-90.
1996: R Buchet; E Tavitian; D Ristig; R Swoboda; U Stauss; H U Gremlich; L de La Fournière; Matthias Staufenbiel; P Frey; D A Lowe
Conformations of synthetic beta peptides in solid state and in aqueous solution: relation to toxicity in PC12 cells.
Biochimica et biophysica acta 1996;1315(1):40-6.
1995: H W Klafki; Paolo Paganetti; Bernd Sommer; Matthias Staufenbiel
Calpain inhibitor I decreases beta A4 secretion from human embryonal kidney cells expressing beta-amyloid precursor protein carrying the APP670/671 double mutation.
Neuroscience letters 1995;201(1):29-32.
1995: Dorothee Abramowski; M Rigo; D Duc; D Hoyer; Matthias Staufenbiel
Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera.
Neuropharmacology 1995;34(12):1635-45.
1995: Matthias Staufenbiel; E Pombo-Villar
[Genetic predisposition for Alzheimer's disease].
Therapeutische Umschau. Revue thérapeutique 1995;52(12):821-5.
1995: Dorothee Abramowski; Matthias Staufenbiel
Identification of the 5-hydroxytryptamine2C receptor as a 60-kDa N-glycosylated protein in choroid plexus and hippocampus.
Journal of neurochemistry 1995;65(2):782-90.
1992: Jukka Hartikka; Matthias Staufenbiel; Hermann Lübbert
Cyclic AMP, but not basic FGF, increases the in vitro survival of mesencephalic dopaminergic neurons and protects them from MPP(+)-induced degeneration.
Journal of neuroscience research 1992;32(2):190-201.