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Matthias Staufenbiel

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Thal Dietmar Rudolf; Capetillo-Zarate Estibaliz; Larionov Sergey; Staufenbiel Matthias; Zurbruegg Stefan; Beckmann Nicolau
Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances.
Grathwohl Stefan A; Kälin Roland E; Bolmont Tristan; Prokop Stefan; Winkelmann Georg; Kaeser Stephan A; Odenthal Jörg; Radde Rebecca; Eldh Therese; Gandy Sam; Aguzzi Adriano; Staufenbiel Matthias; Mathews Paul M; Wolburg Hartwig; Heppner Frank L; Jucker Mathias
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.
Eisele Yvonne S; Bolmont Tristan; Heikenwalder Mathias; Langer Franziska; Jacobson Laura H; Yan Zheng-Xin; Roth Klaus; Aguzzi Adriano; Staufenbiel Matthias; Walker Lary C; Jucker Mathias
Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation.

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2009: Thal Dietmar Rudolf; Capetillo-Zarate Estibaliz; Larionov Sergey; Staufenbiel Matthias; Zurbruegg Stefan; Beckmann Nicolau
Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances.
Neurobiology of aging 2009;30(12):1936-48.
2009: Grathwohl Stefan A; Kälin Roland E; Bolmont Tristan; Prokop Stefan; Winkelmann Georg; Kaeser Stephan A; Odenthal Jörg; Radde Rebecca; Eldh Therese; Gandy Sam; Aguzzi Adriano; Staufenbiel Matthias; Mathews Paul M; Wolburg Hartwig; Heppner Frank L; Jucker Mathias
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.
Nature neuroscience 2009;12(11):1361-3.
2009: Eisele Yvonne S; Bolmont Tristan; Heikenwalder Mathias; Langer Franziska; Jacobson Laura H; Yan Zheng-Xin; Roth Klaus; Aguzzi Adriano; Staufenbiel Matthias; Walker Lary C; Jucker Mathias
Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(31):12926-31.
2009: Wegenast-Braun Bettina M; Fulgencio Maisch Ana; Eicke Daniel; Radde Rebecca; Herzig Martin C; Staufenbiel Matthias; Jucker Mathias; Calhoun Michael E
Independent effects of intra- and extracellular Abeta on learning-related gene expression.
The American journal of pathology 2009;175(1):271-82.
2009: Clavaguera Florence; Bolmont Tristan; Crowther R Anthony; Abramowski Dorothee; Frank Stephan; Probst Alphonse; Fraser Graham; Stalder Anna K; Beibel Martin; Staufenbiel Matthias; Jucker Mathias; Goedert Michel; Tolnay Markus
Transmission and spreading of tauopathy in transgenic mouse brain.
Nature cell biology 2009;11(7):909-13.
2009: Herzig Martin C; Eisele Yvonne S; Staufenbiel Matthias; Jucker Mathias
E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition.
The American journal of pathology 2009;174(3):722-6.
2009: Machauer Rainer; Laumen Kurt; Veenstra Siem; Rondeau Jean-Michel; Tintelnot-Blomley Marina; Betschart Claudia; Jaton Anne-Lise; Desrayaud Sandrine; Staufenbiel Matthias; Rabe Sabine; Paganetti Paolo; Neumann Ulf
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.
Bioorganic & medicinal chemistry letters 2009;19(5):1366-70.
2009: Lefterov Iliya; Fitz Nicholas F; Cronican Andrea; Lefterov Preslav; Staufenbiel Matthias; Koldamova Radosveta
Memory deficits in APP23/Abca1+/- mice correlate with the level of Abeta oligomers.
ASN neuro 2009;1(2):.
2008: Senechal Yann; Prut Laetitia; Kelly Peter H; Staufenbiel Matthias; Natt Francois; Hoyer Daniel; Wiessner Christoph; Dev Kumlesh K
Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA.
Brain research 2008;1243():124-33.
2008: Ji Bin; Maeda Jun; Sawada Makoto; Ono Maiko; Okauchi Takashi; Inaji Motoki; Zhang Ming-Rong; Suzuki Kazutoshi; Ando Kiyoshi; Staufenbiel Matthias; Trojanowski John Q; Lee Virginia M Y; Higuchi Makoto; Suhara Tetsuya
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12255-67.
2008: Qing Hong; He Guiqiong; Ly Philip T T; Fox Christopher J; Staufenbiel Matthias; Cai Fang; Zhang Zhuohua; Wei Shengcai; Sun Xiulian; Chen Chia-Hsiung; Zhou Weihui; Wang Ke; Song Weihong
Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models.
The Journal of experimental medicine 2008;205(12):2781-9.
2008: Abramowski Dorothee; Wiederhold Karl-Heinz; Furrer Ulrich; Jaton Anne-Lise; Neuenschwander Anton; Runser Marie-Josephine; Danner Simone; Reichwald Julia; Ammaturo Domenico; Staab Dieter; Stoeckli Markus; Rueeger Heinrich; Neumann Ulf; Staufenbiel Matthias
Dynamics of Abeta turnover and deposition in different beta-amyloid precursor protein transgenic mouse models following gamma-secretase inhibition.
The Journal of pharmacology and experimental therapeutics 2008;327(2):411-24.
2008: Busche Marc Aurel; Eichhoff Gerhard; Adelsberger Helmuth; Abramowski Dorothee; Wiederhold Karl-Heinz; Haass Christian; Staufenbiel Matthias; Konnerth Arthur; Garaschuk Olga
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.
Science (New York, N.Y.) 2008;321(5896):1686-9.
2008: Schulte-Herbrüggen O; Eckart S; Deicke U; Kühl A; Otten U; Danker-Hopfe H; Abramowski D; Staufenbiel M; Hellweg R
Age-dependent time course of cerebral brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 in APP23 transgenic mice.
Journal of neuroscience research 2008;86(12):2774-83.
2008: Vloeberghs Ellen; Van Dam Debby; Franck Frieda; Serroyen Jan; Geert Molenberghs; Staufenbiel Matthias; De Deyn Peter Paul
Altered ingestive behavior, weight changes, and intact olfactory sense in an APP overexpression model.
Behavioral neuroscience 2008;122(3):491-7.
2008: Ermini Florian V; Grathwohl Stefan; Radde Rebecca; Yamaguchi Masohiro; Staufenbiel Matthias; Palmer Theo D; Jucker Mathias
Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis.
The American journal of pathology 2008;172(6):1520-8.
2008: Van Dijck Annemie; Vloeberghs Ellen; Van Dam Debby; Staufenbiel Matthias; De Deyn Peter Paul
Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory.
Behavioural brain research 2008;190(1):147-51.
2008: Meyer Eric P; Ulmann-Schuler Alexandra; Staufenbiel Matthias; Krucker Thomas
Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3587-92.
2008: Guerreiro Nelson; Staufenbiel Matthias; Gomez-Mancilla Baltazar
Proteomic 2-D DIGE profiling of APP23 transgenic mice brain from pre-plaque and plaque phenotypes.
Journal of Alzheimer's disease : JAD 2008;13(1):17-30.
2008: Hartl Daniela; Rohe Michael; Mao Lei; Staufenbiel Matthias; Zabel Claus; Klose Joachim
Impairment of adolescent hippocampal plasticity in a mouse model for Alzheimer's disease precedes disease phenotype.
PloS one 2008;3(7):e2759.
2007: Bolmont Tristan; Clavaguera Florence; Meyer-Luehmann Melanie; Herzig Martin C; Radde Rebecca; Staufenbiel Matthias; Lewis Jada; Hutton Mike; Tolnay Markus; Jucker Mathias
Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice.
The American journal of pathology 2007;171(6):2012-20.
2007: Kaeser Stephan A; Herzig Martin C; Coomaraswamy Janaky; Kilger Ellen; Selenica Maj-Linda; Winkler David T; Staufenbiel Matthias; Levy Efrat; Grubb Anders; Jucker Mathias
Cystatin C modulates cerebral beta-amyloidosis.
Nature genetics 2007;39(12):1437-9.
2007: Maeda Jun; Ji Bin; Irie Toshiaki; Tomiyama Takami; Maruyama Masahiro; Okauchi Takashi; Staufenbiel Matthias; Iwata Nobuhisa; Ono Maiko; Saido Takaomi C; Suzuki Kazutoshi; Mori Hiroshi; Higuchi Makoto; Suhara Tetsuya
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(41):10957-68.
2007: He Ping; Zhong Zhenyu; Lindholm Kristina; Berning Lilian; Lee Wendy; Lemere Cynthia; Staufenbiel Matthias; Li Rena; Shen Yong
Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice.
The Journal of cell biology 2007;178(5):829-41.
2007: Thal Dietmar Rudolf; Larionov Sergey; Abramowski Dorothee; Wiederhold Karl-Heinz; Van Dooren Tom; Yamaguchi Haruyasu; Haass Christian; Van Leuven Fred; Staufenbiel Matthias; Capetillo-Zarate Estibaliz
Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice.
Neurobiology of aging 2007;28(8):1221-30.
2007: Vloeberghs Ellen; Van Dam Debby; Franck Frieda; Staufenbiel Matthias; De Deyn Peter Paul
Mood and male sexual behaviour in the APP23 model of Alzheimer's disease.
Behavioural brain research 2007;180(2):146-51.
2007: Prut L; Abramowski D; Krucker T; Levy C L; Roberts A J; Staufenbiel M; Wiessner C
Aged APP23 mice show a delay in switching to the use of a strategy in the Barnes maze.
Behavioural brain research 2007;179(1):107-10.
2007: Burbach Guido J; Vlachos Andreas; Ghebremedhin Estifanos; Del Turco Domenico; Coomaraswamy Janaky; Staufenbiel Matthias; Jucker Mathias; Deller Thomas
Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage.
Neurobiology of aging 2007;28(2):202-12.
2007: Lefterov Iliya; Bookout Angie; Wang Zhu; Staufenbiel Matthias; Mangelsdorf David; Koldamova Radosveta
Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment.
Molecular neurodegeneration 2007;2():20.
2007: Herzig Martin C; Paganetti Paolo; Staufenbiel Matthias; Jucker Mathias
BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice.
Neuro-degenerative diseases 2007;4(2-3):127-35.
2006: Vloeberghs Ellen; Van Dam Debby; Coen Katrien; Staufenbiel Matthias; De Deyn Peter Paul
Aggressive male APP23 mice modeling behavioral alterations in dementia.
Behavioral neuroscience 2006;120(6):1380-3.
2006: Sun Xiulian; He Guiqiong; Qing Hong; Zhou Weihui; Dobie Frederick; Cai Fang; Staufenbiel Matthias; Huang L Eric; Song Weihong
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(49):18727-32.
2006: Wolf Susanne A; Kronenberg Golo; Lehmann Kathrin; Blankenship Aaron; Overall Rupert; Staufenbiel Matthias; Kempermann Gerd
Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease.
Biological psychiatry 2006;60(12):1314-23.
2006: Klafki Hans-Wolfgang; Staufenbiel Matthias; Kornhuber Johannes; Wiltfang Jens
Therapeutic approaches to Alzheimer's disease.
Brain : a journal of neurology 2006;129(Pt 11):2840-55.
2006: Capetillo-Zarate Estibaliz; Staufenbiel Matthias; Abramowski Dorothee; Haass Christian; Escher Angelika; Stadelmann Christine; Yamaguchi Haruyasu; Wiestler Otmar D; Thal Dietmar Rudolf
Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology.
Brain : a journal of neurology 2006;129(Pt 11):2992-3005.
2006: Vloeberghs Ellen; Van Dam Debby; D'Hooge Rudi; Staufenbiel Matthias; De Deyn Peter Paul
APP23 mice display working memory impairment in the plus-shaped water maze.
Neuroscience letters 2006;407(1):6-10.
2006: Meyer-Luehmann Melanie; Coomaraswamy Janaky; Bolmont Tristan; Kaeser Stephan; Schaefer Claudia; Kilger Ellen; Neuenschwander Anton; Abramowski Dorothee; Frey Peter; Jaton Anneliese L; Vigouret Jean-Marie; Paganetti Paolo; Walsh Dominic M; Mathews Paul M; Ghiso Jorge; Staufenbiel Matthias; Walker Lary C; Jucker Mathias
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
Science (New York, N.Y.) 2006;313(5794):1781-4.
2006: Heredia Lorena; Helguera Pablo; de Olmos Soledad; Kedikian Gabriela; Solá Vigo Francisco; LaFerla Frank; Staufenbiel Matthias; de Olmos José; Busciglio Jorge; Cáceres Alfredo; Lorenzo Alfredo
Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(24):6533-42.
2006: Okura Yoshio; Miyakoshi Akira; Kohyama Kuniko; Park Il-Kwon; Staufenbiel Matthias; Matsumoto Yoh
Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9619-24.
2006: Huang Shu-Ming; Mouri Akihiro; Kokubo Hideko; Nakajima Ryuichi; Suemoto Takahiro; Higuchi Makoto; Staufenbiel Matthias; Noda Yukihiro; Yamaguchi Haruyasu; Nabeshima Toshitaka; Saido Takaomi C; Iwata Nobuhisa
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
The Journal of biological chemistry 2006;281(26):17941-51.
2006: Heneka Michael T; Ramanathan Mutiah; Jacobs Andreas H; Dumitrescu-Ozimek Lucia; Bilkei-Gorzo Andras; Debeir Thomas; Sastre Magdalena; Galldiks Norbert; Zimmer Andreas; Hoehn Mathias; Heiss Wolf-Dieter; Klockgether Thomas; Staufenbiel Matthias
Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(5):1343-54.
2005: Yue Xu; Lu Melissa; Lancaster Techie; Cao Phillip; Honda Shin-Ichiro; Staufenbiel Matthias; Harada Nobuhiro; Zhong Zhenyu; Shen Yong; Li Rena
Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19198-203.
2005: Koldamova Radosveta; Staufenbiel Matthias; Lefterov Iliya
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.
The Journal of biological chemistry 2005;280(52):43224-35.
2005: Stalder Anna K; Ermini Florian; Bondolfi Luca; Krenger Werner; Burbach Guido J; Deller Thomas; Coomaraswamy Janaky; Staufenbiel Matthias; Landmann Regine; Jucker Mathias
Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(48):11125-32.
2005: Van Dam Debby; Abramowski Dorothee; Staufenbiel Matthias; De Deyn Peter Paul
Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model.
Psychopharmacology 2005;180(1):177-90.
2005: Hintersteiner Martin; Enz Albert; Frey Peter; Jaton Anne-Lise; Kinzy Willy; Kneuer Rainer; Neumann Ulf; Rudin Markus; Staufenbiel Matthias; Stoeckli Markus; Wiederhold Karl-Heinz; Gremlich Hans-Ulrich
In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe.
Nature biotechnology 2005;23(5):577-83.
2005: Boncristiano Sonia; Calhoun Michael E; Howard Victor; Bondolfi Luca; Kaeser Stephan A; Wiederhold Karl-Heinz; Staufenbiel Matthias; Jucker Mathias
Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice.
Neurobiology of aging 2005;26(5):607-13.
2005: Van Dam Debby; Marescau Bart; Engelborghs Sebastiaan; Cremers Thomas; Mulder Jan; Staufenbiel Matthias; De Deyn Peter Paul
Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models.
Neurochemistry international 2005;46(5):409-22.
2005: Van Dam Debby; Vloeberghs Ellen; Abramowski Dorothee; Staufenbiel Matthias; De Deyn Peter Paul P
APP23 mice as a model of Alzheimer's disease: an example of a transgenic approach to modeling a CNS disorder.
CNS spectrums 2005;10(3):207-22.
2005: Lalonde R; Dumont M; Staufenbiel M; Strazielle C
Neurobehavioral characterization of APP23 transgenic mice with the SHIRPA primary screen.
Behavioural brain research 2005;157(1):91-8.
2005: Koldamova Radosveta P; Lefterov Iliya M; Staufenbiel Matthias; Wolfe Darren; Huang Shaohua; Glorioso Joseph C; Walter Michael; Roth Michael G; Lazo John S
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease.
The Journal of biological chemistry 2005;280(6):4079-88.
2004: Vloeberghs Ellen; Van Dam Debby; Engelborghs Sebastiaan; Nagels Guy; Staufenbiel Matthias; De Deyn Peter Paul
Altered circadian locomotor activity in APP23 mice: a model for BPSD disturbances.
The European journal of neuroscience 2004;20(10):2757-66.
2004: Dumont M; Strazielle C; Staufenbiel M; Lalonde R
Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation.
Brain research 2004;1024(1-2):113-21.
2004: Burbach Guido J; Dehn Doris; Del Turco Domenico; Staufenbiel Matthias; Deller Thomas
Laser microdissection reveals regional and cellular differences in GFAP mRNA upregulation following brain injury, axonal denervation, and amyloid plaque deposition.
Glia 2004;48(1):76-84.
2004: Herzig Martin C; Winkler David T; Burgermeister Patrick; Pfeifer Michelle; Kohler Esther; Schmidt Stephen D; Danner Simone; Abramowski Dorothee; Stürchler-Pierrat Christine; Bürki Kurt; van Duinen Sjoerd G; Maat-Schieman Marion L C; Staufenbiel Matthias; Mathews Paul M; Jucker Mathias
Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.
Nature neuroscience 2004;7(9):954-60.
2004: Mueggler Thomas; Meyer-Luehmann Melanie; Rausch Martin; Staufenbiel Matthias; Jucker Mathias; Rudin Markus
Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis.
The European journal of neuroscience 2004;20(3):811-7.
2004: Krucker Thomas; Schuler Alexandra; Meyer Eric P; Staufenbiel Matthias; Beckmann Nicolau
Magnetic resonance angiography and vascular corrosion casting as tools in biomedical research: application to transgenic mice modeling Alzheimer's disease.
Neurological research 2004;26(5):507-16.
2004: Okamura Nobuyuki; Suemoto Takahiro; Shimadzu Hiroshi; Suzuki Masako; Shiomitsu Tsuyoshi; Akatsu Hiroyasu; Yamamoto Takayuki; Staufenbiel Matthias; Yanai Kazuhiko; Arai Hiroyuki; Sasaki Hidetada; Kudo Yukitsuka; Sawada Tohru
Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(10):2535-41.
2004: Burbach Guido J; Hellweg Rainer; Haas Carola A; Del Turco Domenico; Deicke Uwe; Abramowski Dorothee; Jucker Mathias; Staufenbiel Matthias; Deller Thomas
Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(10):2421-30.
2004: Fassbender K; Walter S; Kühl S; Landmann R; Ishii K; Bertsch T; Stalder A K; Muehlhauser F; Liu Y; Ulmer A J; Rivest S; Lentschat A; Gulbins E; Jucker M; Staufenbiel M; Brechtel K; Walter J; Multhaup G; Penke B; Adachi Y; Hartmann T; Beyreuther K
The LPS receptor (CD14) links innate immunity with Alzheimer's disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(1):203-5.
2004: Okamura Nobuyuki; Suemoto Takahiro; Shiomitsu Tsuyoshi; Suzuki Masako; Shimadzu Hiroshi; Akatsu Hiroyasu; Yamamoto Takayuki; Arai Hiroyuki; Sasaki Hidetada; Yanai Kazuhiko; Staufenbiel Matthias; Kudo Yukitsuka; Sawada Tohru
A novel imaging probe for in vivo detection of neuritic and diffuse amyloid plaques in the brain.
Journal of molecular neuroscience : MN 2004;24(2):247-55.
2003: Diez Margarita; Danner Simone; Frey Peter; Sommer Bernd; Staufenbiel Matthias; Wiederhold Karl-Heinz; Hökfelt Tomas
Neuropeptide alterations in the hippocampal formation and cortex of transgenic mice overexpressing beta-amyloid precursor protein (APP) with the Swedish double mutation (APP23).
Neurobiology of disease 2003;14(3):579-94.
2003: Gärtner Ulrich; Brückner Martina K; Krug Sabine; Schmetsdorf Stefanie; Staufenbiel Matthias; Arendt Thomas
Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons.
Acta neuropathologica 2003;106(6):535-44.
2003: Bayer Thomas A; Schäfer Stephanie; Simons Andreas; Kemmling André; Kamer Thomas; Tepest Ralf; Eckert Anne; Schüssel Katrin; Eikenberg Oliver; Sturchler-Pierrat Christine; Abramowski Dorothee; Staufenbiel Matthias; Multhaup Gerd
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14187-92.
2003: Beckmann Nicolau; Schuler Alexandra; Mueggler Thomas; Meyer Eric P; Wiederhold Karl-Heinz; Staufenbiel Matthias; Krucker Thomas
Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8453-9.
2003: Mueggler Thomas; Baumann Diana; Rausch Martin; Staufenbiel Matthias; Rudin Markus
Age-dependent impairment of somatosensory response in the amyloid precursor protein 23 transgenic mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(23):8231-6.
2003: Cataldo Anne M; Petanceska Suzana; Peterhoff Corrinne M; Terio Nicole B; Epstein Charles J; Villar Angela; Carlson Elaine J; Staufenbiel Matthias; Nixon Ralph A
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(17):6788-92.
2003: Meyer-Luehmann Melanie; Stalder Martina; Herzig Martin C; Kaeser Stephan A; Kohler Esther; Pfeifer Michelle; Boncristiano Sonia; Mathews Paul M; Mercken Marc; Abramowski Dorothee; Staufenbiel Matthias; Jucker Mathias
Extracellular amyloid formation and associated pathology in neural grafts.
Nature neuroscience 2003;6(4):370-7.
2003: Kelly P H; Bondolfi L; Hunziker D; Schlecht H-P; Carver K; Maguire E; Abramowski D; Wiederhold K-H; Sturchler-Pierrat C; Jucker M; Bergmann R; Staufenbiel M; Sommer B
Progressive age-related impairment of cognitive behavior in APP23 transgenic mice.
Neurobiology of aging 2003;24(2):365-78.
2003: Van Dam Debby; D'Hooge Rudi; Staufenbiel Matthias; Van Ginneken Chris; Van Meir Frans; De Deyn Peter P
Age-dependent cognitive decline in the APP23 model precedes amyloid deposition.
The European journal of neuroscience 2003;17(2):388-96.
2003: Strazielle C; Sturchler-Pierrat C; Staufenbiel M; Lalonde R
Regional brain cytochrome oxidase activity in beta-amyloid precursor protein transgenic mice with the Swedish mutation.
Neuroscience 2003;118(4):1151-63.
2002: Stoeckli Markus; Staab Dieter; Staufenbiel Matthias; Wiederhold Karl-Heinz; Signor Luca
Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry.
Analytical biochemistry 2002;311(1):33-9.
2002: Pfeifer M; Boncristiano S; Bondolfi L; Stalder A; Deller T; Staufenbiel M; Mathews P M; Jucker M
Cerebral hemorrhage after passive anti-Abeta immunotherapy.
Science (New York, N.Y.) 2002;298(5597):1379.
2002: Lalonde R; Dumont M; Staufenbiel M; Sturchler-Pierrat C; Strazielle C
Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation.
Brain research 2002;956(1):36-44.
2002: Mueggler Thomas; Sturchler-Pierrat Christine; Baumann Diana; Rausch Martin; Staufenbiel Matthias; Rudin Markus
Compromised hemodynamic response in amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(16):7218-24.
2002: Lütjohann Dieter; Brzezinka Andreas; Barth Esther; Abramowski Dorothee; Staufenbiel Matthias; von Bergmann Klaus; Beyreuther Konrad; Multhaup Gerd; Bayer Thomas A
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.
Journal of lipid research 2002;43(7):1078-85.
2002: Winkler David T; Biedermann Luc; Tolnay Markus; Allegrini Peter R; Staufenbiel Matthias; Wiessner Christoph; Jucker Mathias
Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy.
Annals of neurology 2002;51(6):790-3.
2002: Boncristiano Sonia; Calhoun Michael E; Kelly Peter H; Pfeifer Michelle; Bondolfi Luca; Stalder Martina; Phinney Amie L; Abramowski Dorothee; Sturchler-Pierrat Christine; Enz Albert; Sommer Bernd; Staufenbiel Matthias; Jucker Mathias
Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(8):3234-43.
2002: Bodendorf Ursula; Danner Simone; Fischer Frauke; Stefani Muriel; Sturchler-Pierrat Christine; Wiederhold Karl-Heinz; Staufenbiel Matthias; Paganetti Paolo
Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.
Journal of neurochemistry 2002;80(5):799-806.
2002: Kalback Walter; Watson M Desiree; Kokjohn Tyler A; Kuo Yu-Min; Weiss Nicole; Luehrs Dean C; Lopez John; Brune Daniel; Sisodia Sangram S; Staufenbiel Matthias; Emmerling Mark; Roher Alex E
APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
Biochemistry 2002;41(3):922-8.
2002: Bondolfi Luca; Calhoun Michael; Ermini Florian; Kuhn H Georg; Wiederhold Karl-Heinz; Walker Lary; Staufenbiel Matthias; Jucker Mathias
Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(2):515-22.
2002: Büchner M; Huber R; Sturchler-Pierrat C; Staufenbiel M; Riepe M W
Impaired hypoxic tolerance and altered protein binding of NADH in presymptomatic APP23 transgenic mice.
Neuroscience 2002;114(2):285-9.
2001: Kuo Y M; Beach T G; Sue L I; Scott S; Layne K J; Kokjohn T A; Kalback W M; Luehrs D C; Vishnivetskaya T A; Abramowski D; Sturchler-Pierrat C; Staufenbiel M; Weller R O; Roher A E
The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease.
Molecular medicine (Cambridge, Mass.) 2001;7(9):609-18.
2001: Lüth H J; Holzer M; Gärtner U; Staufenbiel M; Arendt T
Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology.
Brain research 2001;913(1):57-67.
2001: Stalder M; Deller T; Staufenbiel M; Jucker M
3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: no evidence of intracellular amyloid.
Neurobiology of aging 2001;22(3):427-34.
2001: Kuo Y M; Kokjohn T A; Beach T G; Sue L I; Brune D; Lopez J C; Kalback W M; Abramowski D; Sturchler-Pierrat C; Staufenbiel M; Roher A E
Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains.
The Journal of biological chemistry 2001;276(16):12991-8.
2001: Winkler D T; Bondolfi L; Herzig M C; Jann L; Calhoun M E; Wiederhold K H; Tolnay M; Staufenbiel M; Jucker M
Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(5):1619-27.
2001: Bornemann K D; Wiederhold K H; Pauli C; Ermini F; Stalder M; Schnell L; Sommer B; Jucker M; Staufenbiel M
Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice.
The American journal of pathology 2001;158(1):63-73.
2000: Bornemann K D; Staufenbiel M
Transgenic mouse models of Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;908():260-6.
2000: Lorenzo A; Yuan M; Zhang Z; Paganetti P A; Sturchler-Pierrat C; Staufenbiel M; Mautino J; Vigo F S; Sommer B; Yankner B A
Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.
Nature neuroscience 2000;3(5):460-4.
2000: Sturchler-Pierrat C; Staufenbiel M
Pathogenic mechanisms of Alzheimer's disease analyzed in the APP23 transgenic mouse model.
Annals of the New York Academy of Sciences 2000;920():134-9.
2000: Sommer B; Sturchler-Pierrat C; Abramowski D; Wiederhold K H; Calhoun M; Jucker M; Kelly P; Staufenbiel M
Transgenic approaches to model Alzheimer's disease.
Reviews in the neurosciences 2000;11(1):47-51.
1999: Calhoun M E; Burgermeister P; Phinney A L; Stalder M; Tolnay M; Wiederhold K H; Abramowski D; Sturchler-Pierrat C; Sommer B; Staufenbiel M; Jucker M
Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(24):14088-93.
1999: Phinney A L; Deller T; Stalder M; Calhoun M E; Frotscher M; Sommer B; Staufenbiel M; Jucker M
Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(19):8552-9.
1999: Stalder M; Phinney A; Probst A; Sommer B; Staufenbiel M; Jucker M
Association of microglia with amyloid plaques in brains of APP23 transgenic mice.
The American journal of pathology 1999;154(6):1673-84.
1998: Calhoun M E; Wiederhold K H; Abramowski D; Phinney A L; Probst A; Sturchler-Pierrat C; Staufenbiel M; Sommer B; Jucker M
Neuron loss in APP transgenic mice.
Nature 1998;395(6704):755-6.
1998: Zhang Z; Hartmann H; Do V M; Abramowski D; Sturchler-Pierrat C; Staufenbiel M; Sommer B; van de Wetering M; Clevers H; Saftig P; De Strooper B; He X; Yankner B A
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.
Nature 1998;395(6703):698-702.
1998: Legutko B; Staufenbiel M; Krieglstein K
Amyloid beta peptide is not a candidate for the neurotrophic activities released from chromaffin cells.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1998;16(5):347-52.
1998: Sommer B; Staufenbiel M
A beta peptide deposition in the brains of transgenic mice: evidence for a key event in Alzheimer's disease pathogenesis.
Molecular psychiatry 1998;3(4):284-6, 282-3.
1997: Sturchler-Pierrat C; Abramowski D; Duke M; Wiederhold K H; Mistl C; Rothacher S; Ledermann B; Bürki K; Frey P; Paganetti P A; Waridel C; Calhoun M E; Jucker M; Probst A; Staufenbiel M; Sommer B
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13287-92.
1997: Staufenbiel M; Pombo-Villar E
[Genetic predisposition to Alzheimer's disease]
Revista de neurologia 1997;25(144):1285-8.
1997: Busciglio J; Hartmann H; Lorenzo A; Wong C; Baumann K; Sommer B; Staufenbiel M; Yankner B A
Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(13):5101-7.
1997: Hartmann H; Busciglio J; Baumann K H; Staufenbiel M; Yankner B A
Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation.
The Journal of biological chemistry 1997;272(23):14505-8.
1997: Schrader-Fischer G; Staufenbiel M; Paganetti P A
Insertion of lysosomal targeting sequences to the amyloid precursor protein reduces secretion of beta A4.
Journal of neurochemistry 1997;68(4):1571-80.
1997: Baumann K; Paganetti P A; Sturchler-Pierrat C; Wong C; Hartmann H; Cescato R; Frey P; Yankner B A; Sommer B; Staufenbiel M
Distinct processing of endogenous and overexpressed recombinant presenilin 1.
Neurobiology of aging 1997;18(2):181-9.
1997: Wiltfang J; Smirnov A; Schnierstein B; Kelemen G; Matthies U; Klafki H W; Staufenbiel M; Hüther G; Rüther E; Kornhuber J
Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.
Electrophoresis 1997;18(3-4):527-32.
1996: Paganetti P A; Lis M; Klafki H W; Staufenbiel M
Amyloid precursor protein truncated at any of the gamma-secretase sites is not cleaved to beta-amyloid.
Journal of neuroscience research 1996;46(3):283-93.
1996: Klafki H; Abramowski D; Swoboda R; Paganetti P A; Staufenbiel M
The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities.
The Journal of biological chemistry 1996;271(45):28655-9.
1996: Klafki H W; Wiltfang J; Staufenbiel M
Electrophoretic separation of betaA4 peptides (1-40) and (1-42).
Analytical biochemistry 1996;237(1):24-9.
1996: Andrä K; Abramowski D; Duke M; Probst A; Wiederhold K H; Bürki K; Goedert M; Sommer B; Staufenbiel M
Expression of APP in transgenic mice: a comparison of neuron-specific promoters.
Neurobiology of aging 1996;17(2):183-90.
1996: Buchet R; Tavitian E; Ristig D; Swoboda R; Stauss U; Gremlich H U; de La Fournière L; Staufenbiel M; Frey P; Lowe D A
Conformations of synthetic beta peptides in solid state and in aqueous solution: relation to toxicity in PC12 cells.
Biochimica et biophysica acta 1996;1315(1):40-6.
1995: Klafki H W; Paganetti P A; Sommer B; Staufenbiel M
Calpain inhibitor I decreases beta A4 secretion from human embryonal kidney cells expressing beta-amyloid precursor protein carrying the APP670/671 double mutation.
Neuroscience letters 1995;201(1):29-32.
1995: Abramowski D; Rigo M; Duc D; Hoyer D; Staufenbiel M
Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera.
Neuropharmacology 1995;34(12):1635-45.
1995: Staufenbiel M; Pombo-Villar E
[Genetic predisposition for Alzheimer's disease]
Therapeutische Umschau. Revue thérapeutique 1995;52(12):821-5.
1995: Abramowski D; Staufenbiel M
Identification of the 5-hydroxytryptamine2C receptor as a 60-kDa N-glycosylated protein in choroid plexus and hippocampus.
Journal of neurochemistry 1995;65(2):782-90.
1992: Hartikka J; Staufenbiel M; Lübbert H
Cyclic AMP, but not basic FGF, increases the in vitro survival of mesencephalic dopaminergic neurons and protects them from MPP(+)-induced degeneration.
Journal of neuroscience research 1992;32(2):190-201.

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