FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Janet Stavnezer

Research Profile

Physiology

Living Beings

Mouse

Anatomy

Chemicals & Drugs

Genes & Molecular Sequences

Genes, Immunoglobulin

Concepts & Ideas

Molecular Sequence Data

Co-author Network

Publications

TOP 3
Anna J Ucher; George W Teebor; Erin K Linehan; Carol E Schrader; Janet Stavnezer
The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.
Sanjay Ranjit; Carol E Schrader; Mrinmay Chakrabarti; Lyne Khair; Erin K Linehan; Anna J Ucher; Janet Stavnezer
AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus.
Janet Stavnezer
Complex regulation and function of activation-induced cytidine deaminase.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Janet Stavnezer (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Anna J Ucher; George W Teebor; Erin K Linehan; Carol E Schrader; Janet Stavnezer
The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.
PloS one 2012;7(4):e36061.
2011: Sanjay Ranjit; Carol E Schrader; Mrinmay Chakrabarti; Lyne Khair; Erin K Linehan; Anna J Ucher; Janet Stavnezer
AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2464-75.
2011: Janet Stavnezer
Complex regulation and function of activation-induced cytidine deaminase.
Trends in immunology 2011;32(5):194-201.
2011: Ori Staszewski; Richard E Baker; Anna J Ucher; Raygene Martier; Janet Stavnezer; Jeroen E J Guikema
Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells.
Molecular cell 2011;41(2):232-42.
2010: Jeroen E J Guikema; Carol E Schrader; Michael H Brodsky; Erin K Linehan; Adam Richards; Nahla El Falaky; Daniel H Li; Hayla K Sluss; Eva Szomolanyi-Tsuda; Janet Stavnezer
p53 represses class switch recombination to IgG2a through its antioxidant function.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6177-87.
2010: Jeroen E J Guikema; Janet Stavnezer; Carol E Schrader
The role of Apex2 in class-switch recombination of immunoglobulin genes.
International immunology 2010;22(3):213; author reply 213-4.
2010: Janet Stavnezer; Andrea Björkman; Likun Du; Alberto Cagigi; Qiang Pan-Hammarstrom
Mapping of switch recombination junctions, a tool for studying DNA repair pathways during immunoglobulin class switching.
Advances in immunology 2010;108():45-109.
2009: Jennifer Eccleston; Carol E Schrader; Karen Yuan; Janet Stavnezer; Erik Selsing
Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):1222-8.
2009: Carol E Schrader; Jeroen E J Guikema; Xiaoming Wu; Janet Stavnezer
The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1517):645-52.
2009: Janet Stavnezer; Joonsoo Kang
The surprising discovery that TGF beta specifically induces the IgA class switch.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):5-7.
2008: Jeroen E J Guikema; Carol E Schrader; Niek G J Leus; Anna Ucher; Erin K Linehan; Uwe Werling; Winfried Edelmann; Janet Stavnezer
Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8450-9.
2008: Janet Stavnezer; Jeroen Guikema; Carol E Schrader
Mechanism and regulation of class switch recombination.
Annual review of immunology 2008;26():261-92.
2007: Jeroen Guikema; Erin K Linehan; Daisuke Tsuchimoto; Yusaku Nakabeppu; Phyllis R Strauss; Janet Stavnezer; Carol E Schrader
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.
The Journal of experimental medicine 2007;204(12):3017-26.
2007: Carol E Schrader; Jeroen Guikema; Erin K Linehan; Erik Selsing; Janet Stavnezer
Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6064-71.
2007: Xiaoming Wu; Janet Stavnezer
DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.
The Journal of experimental medicine 2007;204(7):1677-89.
2007: Denise A Kaminski; Janet Stavnezer
Antibody class switching differs among SJL, C57BL/6 and 129 mice.
International immunology 2007;19(4):545-56.
2007: Denise A Kaminski; Janet Stavnezer
Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b.
European journal of immunology 2007;37(1):240-51.
2006: Denise A Kaminski; Janet Stavnezer
Enhanced IgA class switching in marginal zone and B1 B cells relative to follicular/B2 B cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6025-9.
2006: Sean P Bradley; Denise A Kaminski; Antoine H F M Peters; Thomas Jenuwein; Janet Stavnezer
The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1179-88.
2006: Janet Stavnezer; Carol E Schrader
Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination.
Trends in genetics : TIG 2006;22(1):23-8.
2005: Carol E Schrader; Erin K Linehan; Sofia N Mochegova; Robert T Woodland; Janet Stavnezer
Inducible DNA breaks in Ig S regions are dependent on AID and UNG.
The Journal of experimental medicine 2005;202(4):561-8.
2005: Irene M. Min; Lisa R Rothlein; Carol E Schrader; Janet Stavnezer; Erik Selsing
Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2.
The Journal of experimental medicine 2005;201(12):1885-90.
2005: Seok-Rae Park; Goo-young Seo; Ae-Jin Choi; Janet Stavnezer; Pyeung-Hyeun Kim
Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching.
European journal of immunology 2005;35(3):946-56.
2004: Carol E Schrader; Joycelyn Vardo; Erin K Linehan; Michael Z Twarog; Laura J Niedernhofer; Jan H J Hoeijmakers; Janet Stavnezer
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions.
The Journal of experimental medicine 2004;200(3):321-30.
2004: Janet Stavnezer; Chris T Amemiya
Evolution of isotype switching.
Seminars in immunology 2004;16(4):257-75.
2004: Denise A Kaminski; Janet Stavnezer
Antibody class switching: uncoupling S region accessibility from transcription.
Trends in genetics : TIG 2004;20(8):337-40.
2003: Carol E Schrader; Sean P Bradley; Joycelyn Vardo; Sofia N Mochegova; Erin Flanagan; Janet Stavnezer
Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination.
The EMBO journal 2003;22(21):5893-903.
2003: Irene M. Min; Carol E Schrader; Joycelyn Vardo; Thomas M Luby; Nicole D'Avirro; Janet Stavnezer; Erik Selsing
The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2.
Immunity 2003;19(4):515-24.
2003: Carol E Schrader; Joycelyn Vardo; Janet Stavnezer
Mlh1 can function in antibody class switch recombination independently of Msh2.
The Journal of experimental medicine 2003;197(10):1377-83.
2002: Janet Stavnezer; Sean P Bradley
Does activation-induced deaminase initiate antibody diversification by DNA deamination?
Trends in genetics : TIG 2002;18(11):541-3.
2002: Ursula Storb; Janet Stavnezer
Immunoglobulin genes: generating diversity with AID and UNG.
Current biology : CB 2002;12(21):R725-7.
2002: Elise E Drouin; Carol E Schrader; Janet Stavnezer; Ulla Hansen
The ubiquitously expressed DNA-binding protein late SV40 factor binds Ig switch regions and represses class switching to IgA.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2847-56.
2002: Carol E Schrader; Joycelyn Vardo; Janet Stavnezer
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions.
The Journal of experimental medicine 2002;195(3):367-73.
2001: C S Mao; Janet Stavnezer
Differential regulation of mouse germline Ig gamma 1 and epsilon promoters by IL-4 and CD40.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1522-34.
2001: MJ Shi; S R Park; Pyeung-Hyeun Kim; Janet Stavnezer
Roles of Ets proteins, NF-kappa B and nocodazole in regulating induction of transcription of mouse germline Ig alpha RNA by transforming growth factor-beta 1.
International immunology 2001;13(6):733-46.
2001: Thomas M Luby; Carol E Schrader; Janet Stavnezer; Erik Selsing
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination.
The Journal of experimental medicine 2001;193(2):159-68.
2001: C H Shen; Janet Stavnezer
Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(1):411-23.
2000: Janet Stavnezer
Immunology. A touch of antibody class.
Science (New York, N.Y.) 2000;288(5468):984-5.
2000: Ananth Shanmugam; MJ Shi; L Yauch; Janet Stavnezer; Amy L Kenter
Evidence for class-specific factors in immunoglobulin isotype switching.
The Journal of experimental medicine 2000;191(8):1365-80.
2000: Janet Stavnezer
Molecular processes that regulate class switching.
Current topics in microbiology and immunology 2000;245(2):127-68.
1999: JI Hanai; Lin Feng Chen; T Kanno; N Ohtani-Fujita; W Y Kim; W H Guo; Takeshi Imamura; Y Ishidou; M Fukuchi; MJ Shi; Janet Stavnezer; M Kawabata; Kohei Miyazono; Y Ito
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter.
The Journal of biological chemistry 1999;274(44):31577-82.
1999: Janet Stavnezer; Sean P Bradley; N Rousseau; Todd Pearson; Ananth Shanmugam; D J Waite; P R Rogers; Amy L Kenter
Switch recombination in a transfected plasmid occurs preferentially in a B cell line that undergoes switch recombination of its chromosomal Ig heavy chain genes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):2028-40.
1999: Carol E Schrader; Winfried Edelmann; R Kucherlapati; Janet Stavnezer
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes.
The Journal of experimental medicine 1999;190(3):323-30.
1999: G Qiu; G R Harriman; Janet Stavnezer
Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice.
International immunology 1999;11(1):37-46.
1998: MJ Shi; Janet Stavnezer
CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6751-60.
1998: G Qiu; Janet Stavnezer
Overexpression of BSAP/Pax-5 inhibits switching to IgA and enhances switching to IgE in the I.29 mu B cell line.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(6):2906-18.
1998: S C Lin; H H Wortis; Janet Stavnezer
The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins.
Molecular and cellular biology 1998;18(9):5523-32.
1998: C H Shen; Janet Stavnezer
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription.
Molecular and cellular biology 1998;18(6):3395-404.
1997: L A Iciek; S A Delphin; Janet Stavnezer
CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4769-79.
1997: Carol E Schrader; Janet Stavnezer; H Kikutani; David Parker
Cognate T cell help for CD40-deficient B cells induces c-myc RNA expression, but DNA synthesis requires an additional signal through surface Ig.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(1):153-62.
1996: S C Lin; Janet Stavnezer
Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter.
Molecular and cellular biology 1996;16(9):4591-603.
1996: Janet Stavnezer
Immunoglobulin class switching.
Current opinion in immunology 1996;8(2):199-205.
1996: Janet Stavnezer
Antibody class switching.
Advances in immunology 1996;61():79-146.
1995: S Delphin; Janet Stavnezer
Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter.
Annals of the New York Academy of Sciences 1995;764():123-35.
1995: Janet Stavnezer
Regulation of antibody production and class switching by TGF-beta.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1647-51.
1995: M Lundgren; L Ström; L O Bergquist; Sven Skog; Thomas Heiden; Janet Stavnezer; Eva Severinson
Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members.
European journal of immunology 1995;25(7):2042-51.
1995: S Delphin; Janet Stavnezer
Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.
The Journal of experimental medicine 1995;181(1):181-92.
1994: M Lundgren; C Larsson; A Femino; M Xu; Janet Stavnezer; Eva Severinson
Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(7):2983-95.
1993: P Shockett; Janet Stavnezer
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):6962-76.
1992: Y C Lin; Janet Stavnezer
Regulation of transcription of the germ-line Ig alpha constant region gene by an ATF element and by novel transforming growth factor-beta 1-responsive elements.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):2914-25.
1992: M Z Xu; Janet Stavnezer
Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer.
The EMBO journal 1992;11(1):145-55.
1992: Y C Lin; P Shockett; Janet Stavnezer
Regulation of transcription of the germline immunoglobulin alpha constant region gene.
Current topics in microbiology and immunology 1992;182():157-65.
1991: P Shockett; Janet Stavnezer
Effect of cytokines on switching to IgA and alpha germline transcripts in the B lymphoma I.29 mu. Transforming growth factor-beta activates transcription of the unrearranged C alpha gene.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(12):4374-83.
1991: Y C Lin; P Shockett; Janet Stavnezer
Regulation of the antibody class switch to IgA.
Immunologic research 1991;10(3-4):376-80.
1990: Eva Severinson; C Fernandez; Janet Stavnezer
Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination.
European journal of immunology 1990;20(5):1079-84.
1990: G Radcliffe; Y C Lin; M Julius; K B Marcu; Janet Stavnezer
Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes.
Molecular and cellular biology 1990;10(1):382-6.
1990: M Xu; Janet Stavnezer
Structure of germline immunoglobulin heavy-chain gamma 1 transcripts in interleukin 4 treated mouse spleen cells.
Developmental immunology 1990;1(1):11-7.
1989: C D Jarvis; L E Cannon; Janet Stavnezer
Mouse antibody response to group A streptococcal carbohydrate.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(12):4213-20.
1989: S H Waters; K U Saikh; Janet Stavnezer
A B-cell-specific nuclear protein that binds to DNA sites 5' to immunoglobulin S alpha tandem repeats is regulated during differentiation.
Molecular and cellular biology 1989;9(12):5594-601.
1989: Janet Stavnezer; J L Lasky; Nicholas M Ponzio; M P Scheid; GJ Thorbecke
Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes.
European journal of immunology 1989;19(6):1063-9.
1989: Eva Severinson; H B Moon; S Bergstedt-Lindqvist; U Persson; C Heusser; Janet Stavnezer
Interleukins 4 and 5: mechanisms of action.
Advances in experimental medicine and biology 1989;254():125-33.
1988: Janet Stavnezer; G Radcliffe; Y C Lin; J Nietupski; L Berggren; Roberto Sitia; Eva Severinson
Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7704-8.
1988: D Klein; J Nietupski; S Sirlin; Janet Stavnezer
I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(5):1676-84.
1988: Janet Stavnezer; G Radcliffe; Eva Severinson
Specificity of immunoglobulin heavy chain switching by cultured I.29 B lymphoma cells.
Monographs in allergy 1988;24():197-207.
1985: Roberto Sitia; Anna Rubartelli; H Kikutani; Ulrich Hammerling; Janet Stavnezer
The regulation of membrane-bound and secreted alpha-chain biosynthesis during the differentiation of the B cell lymphoma I.29.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(4):2859-64.
1985: Janet Stavnezer; S Sirlin; J Abbott
Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes.
The Journal of experimental medicine 1985;161(3):577-601.
1984: Janet Stavnezer; J Abbott; S Sirlin
Immunoglobulin heavy chain switching in cultured I.29 murine B lymphoma cells: commitment to an IgA or IgE switch.
Current topics in microbiology and immunology 1984;113():109-16.
1982: Janet Stavnezer; K B Marcu; S Sirlin; B Alhadeff; Ulrich Hammerling
Rearrangements and deletions of immunoglobulin heavy chain genes in the double-producing B cell lymphoma I.29.
Molecular and cellular biology 1982;2(8):1002-13.
1982: Roberto Sitia; H Kikutani; Anna Rubartelli; Y Bushkin; Janet Stavnezer; Ulrich Hammerling
Membrane-bound and secreted IgA contain structurally different alpha-chains.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(2):712-6.
1981: H Kikutani; Roberto Sitia; R A Good; Janet Stavnezer
Synthesis and processing of the alpha heavy chains of secreted and membrane-bound IgA.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(10):6436-40.