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Kwang Seok Ahn

Research Profile

Anatomy

Tumor Cell Line

Chemicals & Drugs

Physiology

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Publications

TOP 3
Mi-Young Jeong; Hyun-Ju Jung; Dae-Seung Kim; Min-Cheol Kim; Sung-Hoon Kim; Su-Jin Kim; Jong-Hyun Lee; Dae-Hee Park; Jinbong Park; Kwang Seok Ahn; Seung-Heon Hong; Yong-Deok Jeon; Jae-Young Um
Saengmaeksan inhibits inflammatory mediators by suppressing RIP-2/caspase-1 activation.
Seong Won Kim; Jun-Hee Lee; Seok-Geun Lee; Dongwoo Nam; Gautam Sethi; Bum-Sang Shim; Hang Bae; Seung-Hoon Choi; Sung-Hoon Kim; Sung-Moo Kim; Kyoo-Seok Ahn; Kwang Seok Ahn
Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades.
Suckbae Han; Chulwon Kim; Jong Hyun Lee; Seok-Geun Lee; Dongwoo Nam; Kyoo-Seok Ahn; Moonjae Cho; Somi K Cho; Won-Seok Chung; Kwang Seok Ahn
Capillarisin inhibits iNOS, COX-2 expression, and proinflammatory cytokines in LPS-induced RAW 264.7 macrophages via the suppression of ERK, JNK, and NF-κB activation.

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All Publications

2013: Mi-Young Jeong; Hyun-Ju Jung; Dae-Seung Kim; Min-Cheol Kim; Sung-Hoon Kim; Su-Jin Kim; Jong-Hyun Lee; Dae-Hee Park; Jinbong Park; Kwang Seok Ahn; Seung-Heon Hong; Yong-Deok Jeon; Jae-Young Um
Saengmaeksan inhibits inflammatory mediators by suppressing RIP-2/caspase-1 activation.
Immunopharmacology and immunotoxicology 2013;35(2):241-50.
2013: Seong Won Kim; Jun-Hee Lee; Seok-Geun Lee; Dongwoo Nam; Gautam Sethi; Bum-Sang Shim; Hang Bae; Seung-Hoon Choi; Sung-Hoon Kim; Sung-Moo Kim; Kyoo-Seok Ahn; Kwang Seok Ahn
Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades.
The Prostate 2013;73(3):296-305.
2013: Suckbae Han; Chulwon Kim; Jong Hyun Lee; Seok-Geun Lee; Dongwoo Nam; Kyoo-Seok Ahn; Moonjae Cho; Somi K Cho; Won-Seok Chung; Kwang Seok Ahn
Capillarisin inhibits iNOS, COX-2 expression, and proinflammatory cytokines in LPS-induced RAW 264.7 macrophages via the suppression of ERK, JNK, and NF-κB activation.
Immunopharmacology and immunotoxicology 2013;35(1):34-42.
2013: Jae-Young Um; Kwang Seok Ahn; Young-Bum Cho; Chul-Ho Jang; Hyeung-Jin Jang; Hyun-Ju Kim; Hye-Lin Kim; Su-Jin Kim; Yoon Bum Kim; Hyejung Lee; Kang-Min Lee; Seok-Geun Lee; Seung Joo Lee; Jinbong Park; Seung-Heon Hong
Proinflammatory cytokine IL-1 β polymorphisms in sudden sensorineural hearing loss.
Immunopharmacology and immunotoxicology 2013;35(1):52-6.
2013: Sang-Yoon Park; Jae-Young Um; Sung-Lyul Lim; Kwang Seok Ahn; Hyeung-Jin Jang; Sung-Hoon Kim; Jun-Hee Lee; Seok-Geun Lee
Embelin induces apoptosis in human glioma cells through inactivating NF-κB.
Journal of pharmacological sciences 2013;121(3):192-9.
2013: Chulwon Kim; Moo-Chang Kim; Sung-Hoon Kim; Sung-Moo Kim; Eun Ha Lee; Dongwoo Nam; Kyoo-Seok Ahn; Seung-Hoon Choi; Sang Hoon Jung; Kwang Seok Ahn
Chrysanthemum indicum L. extract induces apoptosis through suppression of constitutive STAT3 activation in human prostate cancer DU145 cells.
Phytotherapy research : PTR 2013;27(1):30-8.
2012: Seung Ho Baek; Il-Moo Chang; Seung-Hoon Choi; Sung-Hoon Kim; Sung-Moo Kim; Jun-Hee Lee; Dongwoo Nam; Bum-Sang Shim; Kyoo-Seok Ahn; Kwang Seok Ahn
Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9.
Pharmaceutical biology 2012;50(10):1210-8.
2012: Sooho Ok; Bum-Sang Shim; Kyoo-Seok Ahn; Seung-Hoon Choi; Chulwon Kim; Sung-Hoon Kim; Sung-Moo Kim; Dongwoo Nam; Kwang Seok Ahn
Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4.
Immunopharmacology and immunotoxicology 2012;34(5):768-78.
2012: Mi-Ae Lyu; John W Marks; Lan V Pham; Bharat B Aggarwal; Kwang Seok Ahn; Lawrence H Cheung; Min-Jeong Cho; Richard J Ford; Walter N Hittelman; Bokyung Sung; Archito Tamayo; Michael G Rosenblum
The therapeutic effects of rGel/BLyS fusion toxin in in vitro and in vivo models of mantle cell lymphoma.
Biochemical pharmacology 2012;84(4):451-8.
2012: Geumho Lee; Jun-Hee Lee; Seok-Geun Lee; Dongwoo Nam; Bum-Sang Shim; Jae-Young Um; Tae Won Choi; Hyeung-Jin Jang; Sang Hoon Jung; Chulwon Kim; Kyoo-Seok Ahn; Kwang Seok Ahn
Anti-inflammatory activities of Reynoutria elliptica through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways.
Immunopharmacology and immunotoxicology 2012;34(3):454-64.
2012: Eun-Jung Lee; Dongwoo Nam; Bum-Sang Shim; Kyoo-Seok Ahn; Seung-Hoon Choi; Hyeung-Jin Jang; Sang Hoon Jung; Chulwon Kim; Jin-Young Kim; Sung-Hoon Kim; Sung-Moo Kim; Kwang Seok Ahn
Inhibition of LPS-induced inflammatory biomarkers by ethyl acetate fraction of Patrinia scabiosaefolia through suppression of NF-κB activation in RAW 264.7 cells.
Immunopharmacology and immunotoxicology 2012;34(2):282-91.
2012: Nae Hyung Ryu; Bum-Sang Shim; Hyung-Mun Yun; Kyoo-Seok Ahn; Somi K Cho; Seung-Hoon Choi; Hyeung-Jin Jang; Sung-Hoon Kim; Sung-Moo Kim; Seok-Geun Lee; Ashik Mosaddik; Dongwoo Nam; Kyung-Ran Park; Kwang Seok Ahn
A hexane fraction of guava Leaves (Psidium guajava L.) induces anticancer activity by suppressing AKT/mammalian target of rapamycin/ribosomal p70 S6 kinase in human prostate cancer cells.
Journal of medicinal food 2012;15(3):231-41.
2012: Shu Yuan Chiang; Somi K Cho; Seung-Hoon Choi; Hyeung-Jin Jang; Eun-Kyung Jeong; Chulwon Kim; Sung-Hoon Kim; Sung-Moo Kim; Seong Won Kim; Seok-Geun Lee; Yun-Cheol Na; Dongwoo Nam; Kyung-Ran Park; Bum-Sang Shim; Jae-Young Um; Kyoo-Seok Ahn; Kwang Seok Ahn
Antiproliferative effects of Dangyuja (Citrus grandis Osbeck) leaves through suppression of constitutive signal transducer and activator of transcription 3 activation in human prostate carcinoma DU145 cells.
Journal of medicinal food 2012;15(2):152-60.
2012: Inhwan Im; Hyeung-Jin Jang; Chulwon Kim; Sung-Moo Kim; Ashik Mosaddik; Dongwoo Nam; Jeong Ha Park; Kyung-Ran Park; Gautam Sethi; Bum-Sang Shim; Kyoo-Seok Ahn; Somi K Cho; Kwang Seok Ahn
The butanol fraction of guava (Psidium cattleianum Sabine) leaf extract suppresses MMP-2 and MMP-9 expression and activity through the suppression of the ERK1/2 MAPK signaling pathway.
Nutrition and cancer 2012;64(2):255-66.
2011: Kyung-Ran Park; Gautam Sethi; Hyung-Mun Yun; Somi K Cho; Hyeung-Jin Jang; Seok-Geun Lee; Dongwoo Nam; Kwang Seok Ahn
β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation.
Cancer letters 2011;312(2):178-88.
2011: Ji Young Heo; Hyeung-Jin Jang; Hyun Jung Kim; Sung-Hoon Kim; Sung-Moo Kim; Seong Won Kim; Seok-Geun Lee; Dongwoo Nam; Kyung-Ran Park; Sang-Yoon Park; Bum-Sang Shim; Kyoo-Seok Ahn; Seung-Hoon Choi; Kwang Seok Ahn
Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.
Cancer letters 2011;308(1):71-80.
2011: Sang-Yun Lee; Yun-Hee Rhee; Eun-Ok Lee; Hyo-Jeong Lee; Hyo-Jung Lee; Kwang Seok Ahn; Kyoo-Seok Ahn; Soo-Jin Jeong; Min-Hyung Jung; Sun-Hyung Kim; Sung-Hoon Kim
Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells.
Environmental toxicology 2011;26(4):424-31.
2011: Jang Choon Lee; Kwang Seok Ahn; Soo-Jin Jeong; Ji Hoon Jung; Tae-Rin Kwon; Yun-Hee Rhee; Sung-Hoon Kim; Si-Young Kim; Hwi-Joong Yoon; Shudong Zhu; Chang-Yan Chen; Sung-Hoon Kim
Signal transducer and activator of transcription 3 pathway mediates genipin-induced apoptosis in U266 multiple myeloma cells.
Journal of cellular biochemistry 2011;112(6):1552-62.
2011: Hyo-Jeong Lee; Nam-Jun Seo; Soo-Jin Jeong; Yongjin Park; Deok-Beom Jung; Wonil Koh; Hyo-Jung Lee; Eun-Ok Lee; Kwang Seok Ahn; Kyoo-Seok Ahn; Junxuan Lü; Sung-Hoon Kim
Oral administration of penta-O-galloyl-β-D-glucose suppresses triple-negative breast cancer xenograft growth and metastasis in strong association with JAK1-STAT3 inhibition.
Carcinogenesis 2011;32(6):804-11.
2011: Han-Young Kim; Tae Won Choi; Hyun Jung Kim; Sung-Moo Kim; Kyung-Ran Park; Hyeung-Jin Jang; Eun Ha Lee; Chul Young Kim; Sang Hoon Jung; Bum-Sang Shim; Kwang Seok Ahn
A methylene chloride fraction of Saururus chinensis induces apoptosis through the activation of caspase-3 in prostate and breast cancer cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2011;18(7):567-74.
2011: Sung-Hoon Kim; Kwang Seok Ahn; Soo-Jin Jeong; Tae-Rin Kwon; Ji Hoon Jung; Sun-Mi Yun; Ihn Han; Seok-Geun Lee; Dae Keun Kim; Minkyung Kang; Chang-Yan Chen; Jung Weon Lee; Sung-Hoon Kim
Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells.
European journal of pharmacology 2011;654(1):10-6.
2011: Hyun Jung Kim; Sung-Moo Kim; Kyung-Ran Park; Hyeung-Jin Jang; Young-Soon Na; Kyoo-Seok Ahn; Sung-Hoon Kim; Kwang Seok Ahn
Decursin chemosensitizes human multiple myeloma cells through inhibition of STAT3 signaling pathway.
Cancer letters 2011;301(1):29-37.
2011: Jin-Young Kim; Hyun Jung Kim; Sung-Moo Kim; Kyung-Ran Park; Hyeung-Jin Jang; Eun Ha Lee; Sang Hoon Jung; Kwang Seok Ahn
Methylene chloride fraction of the leaves of Thuja orientalis inhibits in vitro inflammatory biomarkers by blocking NF-κB and p38 MAPK signaling and protects mice from lethal endotoxemia.
Journal of ethnopharmacology 2011;133(2):687-95.
2011: Jimin Shin; Kwang Seok Ahn; Seung Hoon Choi; Soo-Jin Jeong; Deok-Beom Jung; Ji Hoon Jung; Seong Gyu Ko; Eun-Ok Lee; Hyo-Jeong Lee; Hyo-Jung Lee; Seok-Geun Lee; Beom Sang Shim; Sung-Hoon Kim
Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells.
PloS one 2011;6(6):e21492.
2011: Jung Il Lee; Young Wan Ha; Tae Won Choi; Hyun Jung Kim; Sung-Moo Kim; Hyeung-Jin Jang; Jung-Hye Choi; Man Ho Choi; Bong Chul Chung; Gautam Sethi; Sung-Hoon Kim; Kyoo-Seok Ahn; Seung-Hoon Choi; Bum-Sang Shim; Kwang Seok Ahn
Cellular uptake of ginsenosides in Korean white ginseng and red ginseng and their apoptotic activities in human breast cancer cells.
Planta medica 2011;77(2):133-40.
2010: Quein Ahn; Soo-Jin Jeong; Hyo-Jung Lee; Hee-Young Kwon; Ihn Han; Hyun Seok Kim; Hyo-Jeong Lee; Eun-Ok Lee; Kwang Seok Ahn; Min-Hyung Jung; Shudong Zhu; Chang-Yan Chen; Sung-Hoon Kim
Inhibition of cyclooxygenase-2-dependent survivin mediates decursin-induced apoptosis in human KBM-5 myeloid leukemia cells.
Cancer letters 2010;298(2):212-21.
2010: Mi-Ae Lyu; Deepak Rai; Kwang Seok Ahn; Bokyung Sung; Lawrence H Cheung; John W Marks; Bharat B Aggarwal; Ricardo Aguiar; Varsha Gandhi; Michael G Rosenblum
The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo.
Neoplasia (New York, N.Y.) 2010;12(5):366-75.
2010: Bokyung Sung; Kwang Seok Ahn; Bharat B Aggarwal
Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathway.
Cancer research 2010;70(8):3259-68.
2010: Jae-Ho Lee; Sun Choi; Yoonji Lee; Hyo-Jeong Lee; Kwan-Hyun Kim; Kwang Seok Ahn; Hyunsu Bae; Hyo-Jung Lee; Eun-Ok Lee; Kyoo-Seok Ahn; Shi Yong Ryu; Junxuan Lü; Sung-Hoon Kim
Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades.
Molecular cancer therapeutics 2010;9(2):389-99.
2010: Chan-Hee Lee; Soo-Jin Jeong; Sun-Mi Yun; Ji-Hyun Kim; Hyo-Jeong Lee; Kwang Seok Ahn; Suk-Hyun Won; Hyun Seok Kim; Hyo-Jung Lee; Kyoo-Seok Ahn; Shudong Zhu; Chang-Yan Chen; Sung-Hoon Kim
Down-regulation of phosphoglucomutase 3 mediates sulforaphane-induced cell death in LNCaP prostate cancer cells.
Proteome science 2010;8():67.
2009: Sang-Hun Kang; Jin-Hyung Kim; Ji-Hyun Kim; Hee-Young Kwon; Eun-Ok Lee; Hyo-Jeong Lee; Hyo-Jung Lee; Sun-Mi Yun; Kwang Seok Ahn; Kyoo-Seok Ahn; Soo-Jin Jeong; Sung-Hoon Kim
Protective effect of Bojungbangdocktang on cisplatin-induced cytotoxicity and apoptosis in MCF-10A breast endothelial cells.
Environmental toxicology and pharmacology 2009;28(3):430-8.
2009: Venkataraman Magesh; Jang-Choon Lee; Kwang Seok Ahn; Hyo-Jung Lee; Hyo-Jeong Lee; Eun-Ok Lee; Bum-Sang Shim; Hee Jae Jung; Jin Sung Kim; Dae Keun Kim; Seung-Hoon Choi; Kyoo-Seok Ahn; Sung-Hoon Kim
Ocimum sanctum induces apoptosis in A549 lung cancer cells and suppresses the in vivo growth of Lewis lung carcinoma cells.
Phytotherapy research : PTR 2009;23(10):1385-91.
2009: Joo-Ho Lee; Hyo-Jung Lee; Hyo-Jeong Lee; Won-Cheol Choi; Seong-Woo Yoon; Seong-Gyu Ko; Kyoo-Seok Ahn; Seung-Hoon Choi; Kwang Seok Ahn; John C Lieske; Sung-Hoon Kim
Rhus verniciflua Stokes prevents cisplatin-induced cytotoxicity and reactive oxygen species production in MDCK-I renal cells and intact mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2009;16(2-3):188-97.
2009: Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Bharat B Aggarwal
Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1.
Molecular pharmacology 2009;75(3):525-33.
2009: Kuzhuvelil B Harikumar; Ajaikumar Kunnumakkara; Kwang Seok Ahn; Preetha Anand; Sunil Krishnan; Sushovan Guha; Bharat B Aggarwal
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Blood 2009;113(9):2003-13.
2008: Gautam Sethi; Kwang Seok Ahn; Bokyung Sung; Ajaikumar Kunnumakkara; Madan M Chaturvedi; Bharat B Aggarwal
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.
Biochemical pharmacology 2008;76(11):1404-16.
2008: Bokyung Sung; Sonia Jhurani; Kwang Seok Ahn; Yoichi Mastuo; Tingfang Yi; Sushovan Guha; Mingyao Liu; Bharat B Aggarwal
Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells.
Cancer research 2008;68(21):8938-44.
2008: Preetha Anand; Ajaikumar Kunnumakkara; Kuzhuvelil B Harikumar; Kwang Seok Ahn; Vladimir Badmaev; Bharat B Aggarwal
Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.
Cancer research 2008;68(21):8861-70.
2008: Kwang Seok Ahn; Gautam Sethi; Madan M Chaturvedi; Bharat B Aggarwal
Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway.
International journal of cancer. Journal international du cancer 2008;123(8):1733-40.
2008: Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis.
Molecular cancer research : MCR 2008;6(6):1059-70.
2008: Gautam Sethi; Kwang Seok Ahn; Bokyung Sung; Bharat B Aggarwal
Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis.
Molecular cancer therapeutics 2008;7(6):1604-14.
2008: Kwang Seok Ahn; Gautam Sethi; Bokyung Sung; Ajay Goel; Ranju Ralhan; Bharat B Aggarwal
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.
Cancer research 2008;68(11):4406-15.
2008: Bokyung Sung; Manoj Pandey; Kwang Seok Ahn; Tingfang Yi; Madan M Chaturvedi; Mingyao Liu; Bharat B Aggarwal
Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis.
Blood 2008;111(10):4880-91.
2008: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway.
Biochemical pharmacology 2008;75(4):907-13.
2007: Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Ajaikumar Kunnumakkara; Madan M Chaturvedi; Bharat B Aggarwal
Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.
Blood 2007;110(10):3517-25.
2007: Gautam Sethi; Kwang Seok Ahn; Madan M Chaturvedi; Bharat B Aggarwal
Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha.
Oncogene 2007;26(52):7324-32.
2007: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Nuclear factor-kappa B: from clone to clinic.
Current molecular medicine 2007;7(7):619-37.
2007: Kwang Seok Ahn; Xing Gong; Gautam Sethi; Madan M Chaturvedi; Anil K Jaiswal; Bharat B Aggarwal
Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases.
Cancer research 2007;67(20):10004-11.
2007: Kwang Seok Ahn; Gautam Sethi; Ta-Hsiang Chao; Saskia T C Neuteboom; Madan M Chaturvedi; Michael A Palladino; Anas Younes; Bharat B Aggarwal
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
Blood 2007;110(7):2286-95.
2007: Ashutosh K Pathak; Manisha Bhutani; Asha S Nair; Kwang Seok Ahn; Arup Chakraborty; Humam Kadara; Sushovan Guha; Gautam Sethi; Bharat B Aggarwal
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
Molecular cancer research : MCR 2007;5(9):943-55.
2007: Gautam Sethi; Kwang Seok Ahn; Dianren Xia; Jonathan M Kurie; Bharat B Aggarwal
Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-kappa B activation and NF-kappa B-regulated antiapoptotic gene products.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1926-33.
2007: Santosh K Sandur; Manoj Pandey; Bokyung Sung; Kwang Seok Ahn; Akira Murakami; Gautam Sethi; Pornngarm Limtrakul; Vladimir Badmaev; Bharat B Aggarwal
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
Carcinogenesis 2007;28(8):1765-73.
2007: Shishir Shishodia; Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.
Biochemical pharmacology 2007;74(1):118-30.
2007: Ajaikumar Kunnumakkara; Asha S Nair; Kwang Seok Ahn; Manoj Pandey; Zhengfang Yi; Mingyao Liu; Bharat B Aggarwal
Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis.
Blood 2007;109(12):5112-21.
2007: Dinesh Khanna; Gautam Sethi; Kwang Seok Ahn; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Amita Aggarwal; Bharat B Aggarwal
Natural products as a gold mine for arthritis treatment.
Current opinion in pharmacology 2007;7(3):344-51.
2007: Gautam Sethi; Kwang Seok Ahn; Manoj Pandey; Bharat B Aggarwal
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation.
Blood 2007;109(7):2727-35.
2007: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2507-16.
2007: Kwang Seok Ahn; Gautam Sethi; Koyamangalath Krishnan; Bharat B Aggarwal
Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
The Journal of biological chemistry 2007;282(1):809-20.
2007: Santosh K Sandur; Kwang Seok Ahn; Haruyo Ichikawa; Gautam Sethi; Shishir Shishodia; Robert A Newman; Bharat B Aggarwal
Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products.
Nutrition and cancer 2007;57(1):78-87.
2007: Kwang Seok Ahn; Gautam Sethi; Bharat B Aggarwal
Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products.
Molecular pharmacology 2007;71(1):209-19.
2006: Bharat B Aggarwal; Gautam Sethi; Kwang Seok Ahn; Santosh K Sandur; Manoj Pandey; Ajaikumar Kunnumakkara; Bokyung Sung; Haruyo Ichikawa
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
Annals of the New York Academy of Sciences 2006;1091():151-69.
2006: Asha S Nair; Shishir Shishodia; Kwang Seok Ahn; Ajaikumar Kunnumakkara; Gautam Sethi; Bharat B Aggarwal
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5612-22.
2006: Kwang Seok Ahn; Gautam Sethi; Shishir Shishodia; Bokyung Sung; Jack L Arbiser; Bharat B Aggarwal
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.
Molecular cancer research : MCR 2006;4(9):621-33.
2006: Gautam Sethi; Kwang Seok Ahn; Santosh K Sandur; Xin Lin; Madan M Chaturvedi; Bharat B Aggarwal
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.
The Journal of biological chemistry 2006;281(33):23425-35.
2006: Kwang Seok Ahn; Gautam Sethi; Abhinav K Jain; Anil K Jaiswal; Bharat B Aggarwal
Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.
The Journal of biological chemistry 2006;281(29):19798-808.
2006: Santosh K Sandur; Haruyo Ichikawa; Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.
The Journal of biological chemistry 2006;281(25):17023-33.
2006: Kwang Seok Ahn; Eun Jung Noh; Kwang-Hyun Cha; Yeong Shik Kim; Soon Sung Lim; Kuk Hyun Shin; Sang Hoon Jung
Inhibitory effects of Irigenin from the rhizomes of Belamcanda chinensis on nitric oxide and prostaglandin E(2) production in murine macrophage RAW 264.7 cells.
Life sciences 2006;78(20):2336-42.
2005: Kwang Seok Ahn; Bharat B Aggarwal
Transcription factor NF-kappaB: a sensor for smoke and stress signals.
Annals of the New York Academy of Sciences 2005;1056():218-33.