FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

John Stegeman

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Anatomy

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Co-author Network

Publications

TOP 3
Juliano Zanette; Bruce Woodin; Afonso C D Bainy; Jared V Goldstone; Matthew J Jenny; Thiago Parente; John J Stegeman
Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis.
Maria E Jönsson; Akira Kubota; Alicia R Timme-Laragy; Bruce Woodin; John J Stegeman
Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYP1 and cox-2 genes in developing zebrafish.
Heather M H Goldstone; Jared V Goldstone; Jennifer J Schlezinger; Saimi Tokunaga; John J Stegeman
EZR1: a novel family of highly expressed retroelements induced by TCDD and regulated by a NF-κB-like factor in embryos of zebrafish (Danio rerio).

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of John Stegeman (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Juliano Zanette; Bruce Woodin; Afonso C D Bainy; Jared V Goldstone; Matthew J Jenny; Thiago Parente; John J Stegeman
Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis.
Aquatic toxicology (Amsterdam, Netherlands) 2013;128-129():101-12.
2012: Maria E Jönsson; Akira Kubota; Alicia R Timme-Laragy; Bruce Woodin; John J Stegeman
Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYP1 and cox-2 genes in developing zebrafish.
Toxicology and applied pharmacology 2012;265(2):166-74.
2012: Heather M H Goldstone; Jared V Goldstone; Jennifer J Schlezinger; Saimi Tokunaga; John J Stegeman
EZR1: a novel family of highly expressed retroelements induced by TCDD and regulated by a NF-κB-like factor in embryos of zebrafish (Danio rerio).
Zebrafish 2012;9(1):15-25.
2012: Jared V Goldstone; John J Stegeman
Methodological approaches to cytochrome P450 profiling in embryos.
Methods in molecular biology (Clifton, N.J.) 2012;889():265-75.
2011: Thiago E M Parente; Francisco J R Paumgartten; Mauro F Rebelo; Paulo M Bisch; Manuela L da-Silva; Jared V Goldstone; Bruce Woodin; John J Stegeman
Structural features of cytochrome P450 1A associated with the absence of EROD activity in liver of the loricariid catfish Pterygoplichthys sp.
Gene 2011;489(2):111-8.
2011: Ann M Tarrant; Lars Behrendt; John J Stegeman; Tim Verslycke
Ecdysteroid receptor from the American lobster Homarus americanus: EcR/RXR isoform cloning and ligand-binding properties.
General and comparative endocrinology 2011;173(2):346-55.
2011: Akira Kubota; John J Stegeman; Bruce Woodin; Toshihiko Iwanaga; Ryo Harano; Richard E Peterson; Takeo Hiraga; Hiroki Teraoka
Role of zebrafish cytochrome P450 CYP1C genes in the reduced mesencephalic vein blood flow caused by activation of AHR2.
Toxicology and applied pharmacology 2011;253(3):244-52.
2011: Akira Kubota; John J Stegeman; Jared V Goldstone; David R Nelson; Eun-Young Kim; Shinsuke Tanabe; Hisato Iwata
Cytochrome P450 CYP2 genes in the common cormorant: Evolutionary relationships with 130 diapsid CYP2 clan sequences and chemical effects on their expression.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2011;153(3):280-9.
2011: Maria E Jönsson; Cecilia Berg; Jared V Goldstone; John J Stegeman
New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development.
Toxicology and applied pharmacology 2011;250(2):170-83.
2010: Ann M Tarrant; John J Stegeman; Tim Verslycke
Altered gene expression associated with epizootic shell disease in the American lobster, Homarus americanus.
Fish & shellfish immunology 2010;29(6):1003-9.
2010: Lars Behrendt; Maria E Jönsson; Jared V Goldstone; John J Stegeman
Induction of cytochrome P450 1 genes and stress response genes in developing zebrafish exposed to ultraviolet radiation.
Aquatic toxicology (Amsterdam, Netherlands) 2010;98(1):74-82.
2010: Joanna Y Wilson; Michael J Moore; John J Stegeman
Catalytic and immunochemical detection of hepatic and extrahepatic microsomal cytochrome P450 1A1 (CYP1A1) in white-sided dolphin (Lagenorhynchus acutus).
Aquatic toxicology (Amsterdam, Netherlands) 2010;96(3):216-24.
2010: Jared V Goldstone; Andrew G McArthur; Akira Kubota; Juliano Zanette; Thiago Parente; Maria E Jönsson; David R Nelson; John J Stegeman
Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish.
BMC genomics 2010;11():643.
2010: Juliano Zanette; Jared V Goldstone; Afonso C D Bainy; John J Stegeman
Identification of CYP genes in Mytilus (mussel) and Crassostrea (oyster) species: first approach to the full complement of cytochrome P450 genes in bivalves.
Marine environmental research 2010;69 Suppl():S1-3.
2009: Maria E Jönsson; Diana G Franks; Bruce Woodin; Matthew J Jenny; Rita A Garrick; Lars Behrendt; Mark E Hahn; John J Stegeman
The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish.
Chemico-biological interactions 2009;181(3):447-54.
2009: Matthew J Jenny; Sibel I Karchner; Diana G Franks; Bruce Woodin; John J Stegeman; Mark E Hahn
Distinct roles of two zebrafish AHR repressors (AHRRa and AHRRb) in embryonic development and regulating the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(2):426-41.
2009: Juliano Zanette; Matthew J Jenny; Jared V Goldstone; Bruce Woodin; Lauren A Watka; Afonso C D Bainy; John J Stegeman
New cytochrome P450 1B1, 1C2 and 1D1 genes in the killifish Fundulus heteroclitus: Basal expression and response of five killifish CYP1s to the AHR agonist PCB126.
Aquatic toxicology (Amsterdam, Netherlands) 2009;93(4):234-43.
2009: Jared V Goldstone; M E Jönsson; L Behrendt; Bruce Woodin; M J Jenny; David Nelson; John J Stegeman
Cytochrome P450 1D1: a novel CYP1A-related gene that is not transcriptionally activated by PCB126 or TCDD.
Archives of biochemistry and biophysics 2009;482(1-2):7-16.
2008: Jared V Goldstone; John J Stegeman
Gene structure of the novel cytochrome P4501D1 genes in stickleback (Gasterosteus aculeatus) and medaka (Oryzias latipes).
Marine environmental research 2008;66(1):19-20.
2008: Eric W Montie; Patricia A Fair; Gregory D Bossart; Greg B Mitchum; Magali Houde; Derek C G Muir; Robert J Letcher; Wayne E McFee; Victoria R Starczak; John J Stegeman; Mark E Hahn
Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United States.
Aquatic toxicology (Amsterdam, Netherlands) 2008;86(3):397-412.
2007: Karen G Burnett; Lisa J Bain; William S Baldwin; Gloria V Callard; Sarah Cohen; Richard T Di Giulio; David H Evans; Marta Gómez-Chiarri; Mark E Hahn; Cindi A Hoover; Sibel I Karchner; Fumi Katoh; Deborah L MacLatchy; William S Marshall; Joel N Meyer; Diane E Nacci; Marjorie F Oleksiak; Bernard B Rees; Thomas D Singer; John J Stegeman; David W Towle; Peter A Van Veld; Wolfgang K Vogelbein; Andrew Whitehead; Richard N Winn; Douglas L Crawford
Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics.
Comparative biochemistry and physiology. Part D, Genomics & proteomics 2007;2(4):257-86.
2007: Jared V Goldstone; Heather M H Goldstone; Ann M Morrison; Ann Tarrant; Suzanne E Kern; Bruce Woodin; John J Stegeman
Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family.
Molecular biology and evolution 2007;24(12):2619-31.
2007: Maria E Jönsson; Matthew J Jenny; Bruce Woodin; Mark E Hahn; John J Stegeman
Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):180-93.
2007: Maria E Jönsson; Rodrigo Orrego; Bruce Woodin; Jared V Goldstone; John J Stegeman
Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish.
Toxicology and applied pharmacology 2007;221(1):29-41.
2007: Joanna Y Wilson; Randall Wells; Alex Aguilar; Asuncion Borrell; Victoria Tornero; Peter J H Reijnders; Michael Moore; John J Stegeman
Correlates of cytochrome P450 1A1 expression in bottlenose dolphin (Tursiops truncatus) integument biopsies.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(1):111-9.
2007: Jahnavi C Prasad; Jared V Goldstone; Carlos J Camacho; Sandor Vajda; John J Stegeman
Ensemble modeling of substrate binding to cytochromes P450: analysis of catalytic differences between CYP1A orthologs.
Biochemistry 2007;46(10):2640-54.
2006: Jared V Goldstone; Amro M Hamdoun; B J Cole; M Howard-Ashby; D W Nebert; M Scally; M Dean; david epel; M E Hahn; John J Stegeman
The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome.
Developmental biology 2006;300(1):366-84.
2006: Robert J Huggett; Jerry M Neff; John J Stegeman; Bruce Woodin; Keith R Parker; John S Brown
Biomarkers of PAH exposure in an intertidal fish species from Prince William Sound, Alaska: 2004-2005.
Environmental science & technology 2006;40(20):6513-7.
2006: Mark J Melancon; Amy L Kutay; Bruce Woodin; John J Stegeman
Evaluating cytochrome p450 in lesser scaup (Aythya affinis) and tree swallow (Tachycineta bicolor) by monooxygenase activity and immunohistochemistry: possible nonlethal assessment by skin immunohistochemistry.
Environmental toxicology and chemistry / SETAC 2006;25(10):2613-7.
2006: Tim Verslycke; Jared V Goldstone; John J Stegeman
Isolation and phylogeny of novel cytochrome P450 genes from tunicates (Ciona spp.): a CYP3 line in early deuterostomes?
Molecular phylogenetics and evolution 2006;40(3):760-71.
2006: Akira Kubota; Hisato Iwata; Heather M H Goldstone; Eun-Young Kim; John J Stegeman; Shinsuke Tanabe
Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds.
Toxicological sciences : an official journal of the Society of Toxicology 2006;92(2):394-408.
2006: Heather M H Goldstone; John J Stegeman
A revised evolutionary history of the CYP1A subfamily: gene duplication, gene conversion, and positive selection.
Journal of molecular evolution 2006;62(6):708-17.
2006: Jennifer J Schlezinger; William D J Struntz; Jared V Goldstone; John J Stegeman
Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners.
Aquatic toxicology (Amsterdam, Netherlands) 2006;77(4):422-32.
2006: Aline Y O Matsuo; Bruce Woodin; Christopher M Reddy; Adalberto L Val; John J Stegeman
Humic substances and crude oil induce cytochrome P450 1A expression in the Amazonian fish species Colossoma macropomum (Tambaqui).
Environmental science & technology 2006;40(8):2851-8.
2006: Rita Anne Garrick; Bruce Woodin; Joanna Y Wilson; Bobby L Middlebrooks; John J Stegeman
Cytochrome P4501A is induced in endothelial cell lines from the kidney and lung of the bottlenose dolphin, Tursiops truncatus.
Aquatic toxicology (Amsterdam, Netherlands) 2006;76(3-4):295-305.
2006: Heather M H Goldstone; John J Stegeman
Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity.
Drug metabolism reviews 2006;38(1-2):261-89.
2005: Joanna Y Wilson; Suzy R Cooke; Michael J Moore; Daniel Martineau; Igor Mikaelian; Donald A Metner; W Lyle Lockhart; John J Stegeman
Systemic effects of arctic pollutants in beluga whales indicated by CYP1A1 expression.
Environmental health perspectives 2005;113(11):1594-9.
2005: Celine A J Godard; Jared V Goldstone; Maya R Said; Richard L Dickerson; Bruce Woodin; John J Stegeman
The new vertebrate CYP1C family: cloning of new subfamily members and phylogenetic analysis.
Biochemical and biophysical research communications 2005;331(4):1016-24.
2005: Heather M Handley-Goldstone; Matthew W Grow; John J Stegeman
Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(1):683-93.
2005: Rita Anne Garrick; Bruce Woodin; John J Stegeman
Cytochrome p4501a induced differentially in endothelial cells cultured from different organs of Anguilla rostrata.
In vitro cellular & developmental biology. Animal 2005;41(1-2):57-63.
2005: Joanna Y Wilson; Andrew G McArthur; John J Stegeman
Characterization of a cetacean aromatase (CYP19) and the phylogeny and functional conservation of vertebrate aromatase.
General and comparative endocrinology 2005;140(1):74-83.
2004: David S Page; Robert J Huggett; John J Stegeman; Keith R Parker; Bruce Woodin; John S Brown; A Edward Bence
Polycyclic aromatic hydrocarbon sources related to biomarker levels in fish from Prince William Sound and the Gulf of Alaska.
Environmental science & technology 2004;38(19):4928-36.
2004: Wade H Powell; Hilary G Morrison; E Jennifer Weil; Sibel I Karchner; Mitchell L Sogin; John J Stegeman; Mark E Hahn
Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus).
Marine environmental research 2004;58(2-5):119-24.
2004: Céline A J Godard; Roxanna M Smolowitz; Joanna Y Wilson; Roger S Payne; John J Stegeman
Induction of cetacean cytochrome P4501A1 by beta-naphthoflavone exposure of skin biopsy slices.
Toxicological sciences : an official journal of the Society of Toxicology 2004;80(2):268-75.
2003: Robert J Huggett; John J Stegeman; David S Page; Keith R Parker; Bruce Woodin; John S Brown
Biomarkers in fish from Prince William Sound and the Gulf of Alaska: 1999-2000.
Environmental science & technology 2003;37(18):4043-51.
2003: Andrew G McArthur; Tove Hegelund; Rachel L Cox; John J Stegeman; Mette Liljenberg; Urban Olsson; Per Sundberg; Malin C Celander
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
Journal of molecular evolution 2003;57(2):200-11.
2003: Marjorie F Oleksiak; Shu Wu; Carol Parker; Wei Qu; Rachel Cox; Darryl C Zeldin; John J Stegeman
Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase.
Archives of biochemistry and biophysics 2003;411(2):223-34.
2003: Michael J Moore; Igor V Mitrofanov; Stefanie S Valentini; Vjacheslav V Volkov; Aleksey V Kurbskiy; Elena N Zhimbey; Lorraine B Eglinton; John J Stegeman
Cytochrome P4501A expression, chemical contaminants and histopathology in roach, goby and sturgeon and chemical contaminants in sediments from the Caspian Sea, Lake Balkhash and the Ily River Delta, Kazakhstan.
Marine pollution bulletin 2003;46(1):107-19.
2002: John J Stegeman; Andrew R Solow; Thomas J Goehl
Enviromental health and the coastal zone.
Environmental health perspectives 2002;110(11):A660-1.
2002: Shannon Mala Bard; Bruce Woodin; John J Stegeman
Expression of P-glycoprotein and cytochrome p450 1A in intertidal fish (Anoplarchus purpurescens) exposed to environmental contaminants.
Aquatic toxicology (Amsterdam, Netherlands) 2002;60(1-2):17-32.
2002: Shannon Mala Bard; Susan M Bello; Mark E Hahn; John J Stegeman
Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics.
Aquatic toxicology (Amsterdam, Netherlands) 2002;59(3-4):237-51.
2002: Eli V Hestermann; John J Stegeman; Mark E Hahn
Relationships among the cell cycle, cell proliferation, and aryl hydrocarbon receptor expression in PLHC-1 cells.
Aquatic toxicology (Amsterdam, Netherlands) 2002;58(3-4):201-13.
2002: Eli V Hestermann; John J Stegeman; Mark E Hahn
Serum withdrawal leads to reduced aryl hydrocarbon receptor expression and loss of cytochrome P4501A inducibility in PLHC-1 cells.
Biochemical pharmacology 2002;63(8):1405-14.
2002: Hisato Iwata; Kouichi Yoshinari; Masahiko Negishi; John J Stegeman
Species-specific responses of constitutively active receptor (CAR)-CYP2B coupling: lack of CYP2B inducer-responsive nuclear translocation of CAR in marine teleost, scup (Stenotomus chrysops).
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2002;131(4):501-10.
2002: Stephen C Jewett; Thomas A Dean; Bruce Woodin; Max K Hoberg; John J Stegeman
Exposure to hydrocarbons 10 years after the Exxon Valdez oil spill: evidence from cytochrome P4501A expression and biliary FACs in nearshore demersal fishes.
Marine environmental research 2002;54(1):21-48.
2001: R L Cox; Thomas M Mariano; D E Heck; Jeffrey D Laskin; John J Stegeman
Nitric oxide synthase sequences in the marine fish Stenotomus chrysops and the sea urchin Arbacia punctulata, and phylogenetic analysis of nitric oxide synthase calmodulin-binding domains.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2001;130(4):479-91.
2001: L A Verbrugge; John P Giesy; D A Verbrugge; Bruce Woodin; John J Stegeman
Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with beta-naphthoflavone or isosafrole.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2001;130(1):67-83.
2001: Jennifer J Schlezinger; John J Stegeman
Induction and suppression of cytochrome P450 1A by 3,3',4,4',5-pentachlorobiphenyl and its relationship to oxidative stress in the marine fish scup (Stenotomus chrysops).
Aquatic toxicology (Amsterdam, Netherlands) 2001;52(2):101-15.
2001: Susan M Bello; Diana G Franks; John J Stegeman; Mark E Hahn
Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(1):77-91.
2001: John J Stegeman; Jennifer J Schlezinger; J E Craddock; Donald E Tillitt
Cytochrome P450 1A expression in midwater fishes: potential effects of chemical contaminants in remote oceanic zones.
Environmental science & technology 2001;35(1):54-62.
2001: Y W Huang; John J Stegeman; Bruce Woodin; William H Karasov
Immunohistochemical localization of cytochrome P4501A induced by 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in multiple organs of northern leopard frogs, Rana pipiens.
Environmental toxicology and chemistry / SETAC 2001;20(1):191-7.
2000: Eli V Hestermann; John J Stegeman; Mark E Hahn
Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency.
Toxicology and applied pharmacology 2000;168(2):160-72.
2000: C A Godard; M J Leaver; M R Said; R L Dickerson; S George; John J Stegeman
Identification of cytochrome P450 1B-like sequences in two teleost fish species (scup, Stenotomus chrysops and plaice, Pleuronectes platessa) and in a cetacean (striped dolphin, Stenella coeruleoalba).
Marine environmental research 2000;50(1-5):7-10.
2000: RD White; D Shea; Jennifer J Schlezinger; Mark E Hahn; John J Stegeman
In vitro metabolism of polychlorinated biphenyl congeners by beluga whale (Delphinapterus leucas) and pilot whale (Globicephala melas) and relationship to cytochrome P450 expression.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2000;126(3):267-84.
2000: Jennifer J Schlezinger; John J Stegeman
Dose and inducer-dependent induction of cytochrome P450 1A in endothelia of the eel, including in the swimbladder rete mirabile, a model microvascular structure.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(6):701-8.
2000: Jennifer J Schlezinger; C E Blickarz; Koren K Mann; Stefan Doerre; John J Stegeman
Identification of NF-kappaB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists.
Chemico-biological interactions 2000;126(2):137-57.
2000: H Iwata; John J Stegeman
In situ RT-PCR detection of CYP1A mRNA in pharyngeal epithelium and chondroid cells from chemically untreated fish: involvement in vertebrate craniofacial skeletal development?
Biochemical and biophysical research communications 2000;271(1):130-7.
2000: Jennifer J Schlezinger; J Keller; L A Verbrugge; John J Stegeman
3,3',4,4'-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2000;125(3):273-86.
2000: Eli V Hestermann; John J Stegeman; Mark E Hahn
Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(2):316-25.
2000: Marjorie F Oleksiak; S Wu; Carol Parker; Sibel I Karchner; John J Stegeman; Darryl C Zeldin
Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns.
The Journal of biological chemistry 2000;275(4):2312-21.
1999: Jennifer J Schlezinger; RD White; John J Stegeman
Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As.
Molecular pharmacology 1999;56(3):588-97.
1998: Karl Fent; Bruce Woodin; John J Stegeman
Effects of triphenyltin and other organotins on hepatic monooxygenase system in fish.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1998;121(1-3):277-88.
1998: Hilary G Morrison; E Jennifer Weil; Sibel I Karchner; Mitchell L Sogin; John J Stegeman
Molecular cloning of CYP1A from the estuarine fish Fundulus heteroclitus and phylogenetic analysis of CYP1 genes: update with new sequences.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1998;121(1-3):231-40.
1998: John J Stegeman; D R Livingstone
Forms and functions of cytochrome P450.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1998;121(1-3):1-3.
1998: Mark E Hahn; Bruce Woodin; John J Stegeman; Donald E Tillitt
Aryl hydrocarbon receptor function in early vertebrates: inducibility of cytochrome P450 1A in agnathan and elasmobranch fish.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1998;120(1):67-75.
1998: A Yawetz; Bruce Woodin; John J Stegeman
Cytochromes P450 in liver of the turtle Chrysemys picta picta and the induction and partial purification of CYP1A-like proteins.
Biochimica et biophysica acta 1998;1381(1):12-26.
1998: Jennifer J Schlezinger; Carol Parker; Darryl C Zeldin; John J Stegeman
Arachidonic acid metabolism in the marine fish Stenotomus chrysops (Scup) and the effects of cytochrome P450 1A inducers.
Archives of biochemistry and biophysics 1998;353(2):265-75.
1998: S M Cantrell; J Joy-Schlezinger; John J Stegeman; Donald E Tillitt; Mark Hannink
Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity.
Toxicology and applied pharmacology 1998;148(1):24-34.
1997: Malin C Celander; John J Stegeman
Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A genes.
Biochemical and biophysical research communications 1997;236(2):306-12.
1997: RD White; D Shea; John J Stegeman
Metabolism of the aryl hydrocarbon receptor agonist 3,3',4,4'-tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(5):564-72.
1997: RD White; D Shea; Andrew R Solow; John J Stegeman
Induction and post-transcriptional suppression of hepatic cytochrome P450 1A1 by 3,3',4,4'-tetrachlorobiphenyl.
Biochemical pharmacology 1997;53(7):1029-40.
1997: Malin C Celander; R Weisbrod; John J Stegeman
Glucocorticoid potentiation of cytochrome P4501A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin in porcine and human endothelial cells in culture.
Biochemical and biophysical research communications 1997;232(3):749-53.
1997: John J Stegeman; Bruce Woodin; H Singh; Marjorie F Oleksiak; Malin C Celander
Cytochromes P450 (CYP) in tropical fishes: catalytic activities, expression of multiple CYP proteins and high levels of microsomal P450 in liver of fishes from Bermuda.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1997;116(1):61-75.
1996: Sean W Kennedy; Angela Lorenzen; S P Jones; Mark E Hahn; John J Stegeman
Cytochrome P4501A induction in avian hepatocyte cultures: a promising approach for predicting the sensitivity of avian species to toxic effects of halogenated aromatic hydrocarbons.
Toxicology and applied pharmacology 1996;141(1):214-30.
1996: M J Moore; John J Stegeman
Hepatocyte vacuolation and autolytic changes in the liver of pilot whales, Globicephala melas, stranded on Cape Cod, MA, USA.
The Science of the total environment 1996;186(1-2):105-8.
1996: Malin C Celander; Mark E Hahn; John J Stegeman
Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A.
Archives of biochemistry and biophysics 1996;329(1):113-22.
1995: Hilary G Morrison; Marjorie F Oleksiak; N W Cornell; Mitchell L Sogin; John J Stegeman
Identification of cytochrome P-450 1A (CYP1A) genes from two teleost fish, toadfish (Opsanus tau) and scup (Stenotomus chrysops), and phylogenetic analysis of CYP1A genes.
The Biochemical journal 1995;308 ( Pt 1)():97-104.
1995: John J Stegeman; Mark E Hahn; R Weisbrod; Bruce Woodin; J S Joy; S Najibi; R A Cohen
Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells.
Molecular pharmacology 1995;47(2):296-306.
1994: Mark E Hahn; John J Stegeman
Regulation of cytochrome P4501A1 in teleosts: sustained induction of CYP1A1 mRNA, protein, and catalytic activity by 2,3,7,8-tetrachlorodibenzofuran in the marine fish Stenotomus chrysops.
Toxicology and applied pharmacology 1994;127(2):187-98.
1994: P J Kloepper-Sams; John J Stegeman
Turnover of hepatic microsomal cytochrome P4501A protein and heme in beta-naphthoflavone-induced Fundulus heteroclitus.
Molecular marine biology and biotechnology 1994;3(3):171-83.
1994: R D White; Mark E Hahn; W L Lockhart; John J Stegeman
Catalytic and immunochemical characterization of hepatic microsomal cytochromes P450 in beluga whale (Delphinapterus leucas).
Toxicology and applied pharmacology 1994;126(1):45-57.
1994: Mark E Hahn; A Poland; E Glover; John J Stegeman
Photoaffinity labeling of the Ah receptor: phylogenetic survey of diverse vertebrate and invertebrate species.
Archives of biochemistry and biophysics 1994;310(1):218-28.
1992: R M Smolowitz; M E Schultz; John J Stegeman
Cytochrome P4501A induction in tissues, including olfactory epithelium, of topminnows (Poeciliopsis spp.) by waterborne benzo[a]pyrene.
Carcinogenesis 1992;13(12):2395-402.
1992: P J Kloepper-Sams; John J Stegeman
Effects of temperature acclimation on the expression of hepatic cytochrome P4501A mRNA and protein in the fish Fundulus heteroclitus.
Archives of biochemistry and biophysics 1992;299(1):38-46.
1992: P A Van Veld; W K Vogelbein; R Smolowitz; Bruce Woodin; John J Stegeman
Cytochrome P450IA1 in hepatic lesions of a teleost fish (Fundulus heteroclitus) collected from a polycyclic aromatic hydrocarbon-contaminated site.
Carcinogenesis 1992;13(3):505-7.
1991: John J Stegeman; R M Smolowitz; Mark E Hahn
Immunohistochemical localization of environmentally induced cytochrome P450IA1 in multiple organs of the marine teleost Stenotomus chrysops (Scup).
Toxicology and applied pharmacology 1991;110(3):486-504.
1991: E S Gray; Bruce Woodin; John J Stegeman
Sex differences in hepatic monooxygenases in winter flounder (Pseudopleuronectes americanus) and scup (Stenotomus chrysops) and regulation of P450 forms by estradiol.
The Journal of experimental zoology 1991;259(3):330-42.
1991: John J Stegeman; J J Lech
Cytochrome P-450 monooxygenase systems in aquatic species: carcinogen metabolism and biomarkers for carcinogen and pollutant exposure.
Environmental health perspectives 1991;90():101-9.
1991: R M Smolowitz; Mark E Hahn; John J Stegeman
Immunohistochemical localization of cytochrome P-450IA1 induced by 3,3',4,4'-tetrachlorobiphenyl and by 2,3,7,8-tetrachlorodibenzoafuran in liver and extrahepatic tissues of the teleost Stenotomus chrysops (scup).
Drug metabolism and disposition: the biological fate of chemicals 1991;19(1):113-23.
1990: John J Stegeman; Bruce Woodin; R M Smolowitz
Structure, function and regulation of cytochrome P-450 forms in fish.
Biochemical Society transactions 1990;18(1):19-21.
1990: A M Pajor; John J Stegeman; P Thomas; Bruce Woodin
Feminization of the hepatic microsomal cytochrome P-450 system in brook trout by estradiol, testosterone, and pituitary factors.
The Journal of experimental zoology 1990;253(1):51-60.
1989: John J Stegeman; M R Miller; D E Hinton
Cytochrome P450IA1 induction and localization in endothelium of vertebrate (teleost) heart.
Molecular pharmacology 1989;36(5):723-9.
1989: J W Gooch; A A Elskus; P J Kloepper-Sams; Mark E Hahn; John J Stegeman
Effects of ortho- and non-ortho-substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (Stenotomus chrysops).
Toxicology and applied pharmacology 1989;98(3):422-33.
1989: P J Kloepper-Sams; John J Stegeman
The temporal relationships between P450E protein content, catalytic activity, and mRNA levels in the teleost Fundulus heteroclitus following treatment with beta-naphthoflavone.
Archives of biochemistry and biophysics 1989;268(2):525-35.
1988: H Singh; R W Griffith; A Takahashi; H Kawauchi; P Thomas; John J Stegeman
Regulation of gonadal steroidogenesis in Fundulus heteroclitus by recombinant salmon growth hormone and purified salmon prolactin.
General and comparative endocrinology 1988;72(1):144-53.
1988: P A van Veld; John J Stegeman; Bruce Woodin; J S Patton; Richard F Lee
Induction of monooxygenase activity in the intestine of spot (Leiostomus xanthurus), a marine teleost, by dietary polycyclic aromatic hydrocarbons.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(5):659-65.
1987: K A Goddard; R J Schultz; John J Stegeman
Uptake, toxicity, and distribution of benzo[a]pyrene and monooxygenase induction in the topminnows Poeciliopsis monacha and Poeciliopsis lucida.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(4):449-55.
1987: John J Stegeman; P J Kloepper-Sams
Cytochrome P-450 isozymes and monooxygenase activity in aquatic animals.
Environmental health perspectives 1987;71():87-95.
1987: P J Kloepper-Sams; S S Park; H V Gelboin; John J Stegeman
Specificity and cross-reactivity of monoclonal and polyclonal antibodies against cytochrome P-450E of the marine fish scup.
Archives of biochemistry and biophysics 1987;253(1):268-78.
1986: A V Klotz; John J Stegeman; Bruce Woodin; E A Snowberger; P E Thomas; C Walsh
Cytochrome P-450 isozymes from the marine teleost Stenotomus chrysops: their roles in steroid hydroxylation and the influence of cytochrome b5.
Archives of biochemistry and biophysics 1986;249(2):326-38.
1986: S S Park; H Miller; A V Klotz; P J Kloepper-Sams; John J Stegeman; H V Gelboin
Monoclonal antibodies to liver microsomal cytochrome P-450E of the marine fish Stenotomus chrysops (scup): cross reactivity with 3-methylcholanthrene induced rat cytochrome P-450.
Archives of biochemistry and biophysics 1986;249(2):339-50.
1986: N W Cornell; John J Stegeman; M J Kerich; Bruce Woodin
Metabolite and enzyme contents of freeze-clamped liver of the marine fish Stenotomus chrysops.
Comparative biochemistry and physiology. B, Comparative biochemistry 1986;85(3):669-74.
1984: A V Klotz; John J Stegeman; C Walsh
An alternative 7-ethoxyresorufin O-deethylase activity assay: a continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity.
Analytical biochemistry 1984;140(1):138-45.
1984: John J Stegeman; Bruce Woodin; R L Binder
Patterns of benzo[a]pyrene metabolism by varied species, organs, and developmental stages of fish.
National Cancer Institute monograph 1984;65():371-7.
1983: A V Klotz; John J Stegeman; C Walsh
An aryl hydrocarbon hydroxylating hepatic cytochrome P-450 from the marine fish Stenotomus chrysops.
Archives of biochemistry and biophysics 1983;226(2):578-92.
1982: John J Stegeman; Bruce Woodin; A V Klotz; R E Wolke; N R Orme-Johnson
Cytochrome P-450 and monooxygenase activity in cardiac microsomes from the fish Stenotomus chrysops.
Molecular pharmacology 1982;21(2):517-26.
1980: John J Stegeman; Bruce Woodin
The metabolism of alpha-naphthoflavone (7,8-benzoflavone) by hepatic microsomes from the marine fish Stenotomus versicolor.
Biochemical and biophysical research communications 1980;95(1):328-33.