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John Stegeman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Living Beings

Physiology

Enzyme Induction

Anatomy

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Amino Acid Sequence

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Immunohistochemistry

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Co-Publications
Name
34
Woodin, Bruce
22
Hahn, Mark
10
Goldstone, Jared
9
Schlezinger, Jennifer
5
Wilson, Joanna
5
Celander, Malin
4
Goldstone, Heather
4
Karchner, Sibel
4
Hestermann, Eli
4
Oleksiak, Marjorie
4
White, RD
3
Parker, Carol
3
Morrison, Hilary
3
Huggett, Robert
3
Zeldin, Darryl

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Publications

TOP 3
Jönsson Maria E; Franks Diana G; Woodin Bruce R; Jenny Matthew J; Garrick Rita A; Behrendt Lars; Hahn Mark E; Stegeman John J
The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish.
Jenny Matthew J; Karchner Sibel I; Franks Diana G; Woodin Bruce R; Stegeman John J; Hahn Mark E
Distinct roles of two zebrafish AHR repressors (AHRRa and AHRRb) in embryonic development and regulating the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Zanette Juliano; Jenny Matthew J; Goldstone Jared V; Woodin Bruce R; Watka Lauren A; Bainy Afonso C D; Stegeman John J
New cytochrome P450 1B1, 1C2 and 1D1 genes in the killifish Fundulus heteroclitus: Basal expression and response of five killifish CYP1s to the AHR agonist PCB126.

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All Publications

2009: Jönsson Maria E; Franks Diana G; Woodin Bruce R; Jenny Matthew J; Garrick Rita A; Behrendt Lars; Hahn Mark E; Stegeman John J
The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) binds multiple AHRs and induces multiple CYP1 genes via AHR2 in zebrafish.
Chemico-biological interactions 2009;181(3):447-54.
2009: Jenny Matthew J; Karchner Sibel I; Franks Diana G; Woodin Bruce R; Stegeman John J; Hahn Mark E
Distinct roles of two zebrafish AHR repressors (AHRRa and AHRRb) in embryonic development and regulating the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicological sciences : an official journal of the Society of Toxicology 2009;110(2):426-41.
2009: Zanette Juliano; Jenny Matthew J; Goldstone Jared V; Woodin Bruce R; Watka Lauren A; Bainy Afonso C D; Stegeman John J
New cytochrome P450 1B1, 1C2 and 1D1 genes in the killifish Fundulus heteroclitus: Basal expression and response of five killifish CYP1s to the AHR agonist PCB126.
Aquatic toxicology (Amsterdam, Netherlands) 2009;93(4):234-43.
2009: Goldstone J V; Jönsson M E; Behrendt L; Woodin B R; Jenny M J; Nelson D R; Stegeman J J
Cytochrome P450 1D1: a novel CYP1A-related gene that is not transcriptionally activated by PCB126 or TCDD.
Archives of biochemistry and biophysics 2009;482(1-2):7-16.
2008: Goldstone Jared V; Stegeman John J
Gene structure of the novel cytochrome P4501D1 genes in stickleback (Gasterosteus aculeatus) and medaka (Oryzias latipes).
Marine environmental research 2008;66(1):19-20.
2008: Montie Eric W; Fair Patricia A; Bossart Gregory D; Mitchum Greg B; Houde Magali; Muir Derek C G; Letcher Robert J; McFee Wayne E; Starczak Victoria R; Stegeman John J; Hahn Mark E
Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United States.
Aquatic toxicology (Amsterdam, Netherlands) 2008;86(3):397-412.
2007: Goldstone Jared V; Goldstone Heather M H; Morrison Ann M; Tarrant Ann; Kern Suzanne E; Woodin Bruce R; Stegeman John J
Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family.
Molecular biology and evolution 2007;24(12):2619-31.
2007: Jönsson Maria E; Jenny Matthew J; Woodin Bruce R; Hahn Mark E; Stegeman John J
Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):180-93.
2007: Jönsson Maria E; Orrego Rodrigo; Woodin Bruce R; Goldstone Jared V; Stegeman John J
Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish.
Toxicology and applied pharmacology 2007;221(1):29-41.
2007: Wilson Joanna Y; Wells Randall; Aguilar Alex; Borrell Asuncion; Tornero Victoria; Reijnders Peter; Moore Michael; Stegeman John J
Correlates of cytochrome P450 1A1 expression in bottlenose dolphin (Tursiops truncatus) integument biopsies.
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(1):111-9.
2007: Prasad Jahnavi C; Goldstone Jared V; Camacho Carlos J; Vajda Sandor; Stegeman John J
Ensemble modeling of substrate binding to cytochromes P450: analysis of catalytic differences between CYP1A orthologs.
Biochemistry 2007;46(10):2640-54.
2006: Goldstone J V; Hamdoun A; Cole B J; Howard-Ashby M; Nebert D W; Scally M; Dean M; Epel D; Hahn M E; Stegeman J J
The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome.
Developmental biology 2006;300(1):366-84.
2006: Huggett Robert J; Neff Jerry M; Stegeman John J; Woodin Bruce; Parker Keith R; Brown John S
Biomarkers of PAH exposure in an intertidal fish species from Prince William Sound, Alaska: 2004-2005.
Environmental science & technology 2006;40(20):6513-7.
2006: Melancon Mark J; Kutay Amy L; Woodin Bruce R; Stegeman John J
Evaluating cytochrome p450 in lesser scaup (Aythya affinis) and tree swallow (Tachycineta bicolor) by monooxygenase activity and immunohistochemistry: possible nonlethal assessment by skin immunohistochemistry.
Environmental toxicology and chemistry / SETAC 2006;25(10):2613-7.
2006: Verslycke Tim; Goldstone Jared V; Stegeman John J
Isolation and phylogeny of novel cytochrome P450 genes from tunicates (Ciona spp.): a CYP3 line in early deuterostomes?
Molecular phylogenetics and evolution 2006;40(3):760-71.
2006: Kubota Akira; Iwata Hisato; Goldstone Heather M H; Kim Eun-Young; Stegeman John J; Tanabe Shinsuke
Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds.
Toxicological sciences : an official journal of the Society of Toxicology 2006;92(2):394-408.
2006: Goldstone Heather M H; Stegeman John J
A revised evolutionary history of the CYP1A subfamily: gene duplication, gene conversion, and positive selection.
Journal of molecular evolution 2006;62(6):708-17.
2006: Schlezinger Jennifer J; Struntz William D J; Goldstone Jared V; Stegeman John J
Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners.
Aquatic toxicology (Amsterdam, Netherlands) 2006;77(4):422-32.
2006: Matsuo Aline Y O; Woodin Bruce R; Reddy Christopher M; Val Adalberto L; Stegeman John J
Humic substances and crude oil induce cytochrome P450 1A expression in the Amazonian fish species Colossoma macropomum (Tambaqui).
Environmental science & technology 2006;40(8):2851-8.
2006: Garrick Rita Anne; Woodin Bruce R; Wilson Joanna Y; Middlebrooks Bobby L; Stegeman John J
Cytochrome P4501A is induced in endothelial cell lines from the kidney and lung of the bottlenose dolphin, Tursiops truncatus.
Aquatic toxicology (Amsterdam, Netherlands) 2006;76(3-4):295-305.
2006: Goldstone Heather M H; Stegeman John J
Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity.
Drug metabolism reviews 2006;38(1-2):261-89.
2005: Wilson Joanna Y; Cooke Suzy R; Moore Michael J; Martineau Daniel; Mikaelian Igor; Metner Donald A; Lockhart W Lyle; Stegeman John J
Systemic effects of arctic pollutants in beluga whales indicated by CYP1A1 expression.
Environmental health perspectives 2005;113(11):1594-9.
2005: Godard Celine A J; Goldstone Jared V; Said Maya R; Dickerson Richard L; Woodin Bruce R; Stegeman John J
The new vertebrate CYP1C family: cloning of new subfamily members and phylogenetic analysis.
Biochemical and biophysical research communications 2005;331(4):1016-24.
2005: Handley-Goldstone Heather M; Grow Matthew W; Stegeman John J
Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos.
Toxicological sciences : an official journal of the Society of Toxicology 2005;85(1):683-93.
2005: Garrick Rita Anne; Woodin Bruce R; Stegeman John J
Cytochrome p4501a induced differentially in endothelial cells cultured from different organs of Anguilla rostrata.
In vitro cellular & developmental biology. Animal 2005;41(1-2):57-63.
2005: Wilson Joanna Y; McArthur Andrew G; Stegeman John J
Characterization of a cetacean aromatase (CYP19) and the phylogeny and functional conservation of vertebrate aromatase.
General and comparative endocrinology 2005;140(1):74-83.
2004: Page David S; Huggett Robert J; Stegeman John J; Parker Keith R; Woodin Bruce; Brown John S; Bence A Edward
Polycyclic aromatic hydrocarbon sources related to biomarker levels in fish from Prince William Sound and the Gulf of Alaska.
Environmental science & technology 2004;38(19):4928-36.
2004: Powell Wade H; Morrison Hilary G; Weil E Jennifer; Karchner Sibel I; Sogin Mitchell L; Stegeman John J; Hahn Mark E
Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus).
Marine environmental research 2004;58(2-5):119-24.
2004: Godard Céline A J; Smolowitz Roxanna M; Wilson Joanna Y; Payne Roger S; Stegeman John J
Induction of cetacean cytochrome P4501A1 by beta-naphthoflavone exposure of skin biopsy slices.
Toxicological sciences : an official journal of the Society of Toxicology 2004;80(2):268-75.
2003: Huggett Robert J; Stegeman John J; Page David S; Parker Keith R; Woodin Bruce; Brown John S
Biomarkers in fish from Prince William Sound and the Gulf of Alaska: 1999-2000.
Environmental science & technology 2003;37(18):4043-51.
2003: McArthur Andrew G; Hegelund Tove; Cox Rachel L; Stegeman John J; Liljenberg Mette; Olsson Urban; Sundberg Per; Celander Malin C
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
Journal of molecular evolution 2003;57(2):200-11.
2003: Oleksiak Marjorie F; Wu Shu; Parker Carol; Qu Wei; Cox Rachel; Zeldin Darryl C; Stegeman John J
Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase.
Archives of biochemistry and biophysics 2003;411(2):223-34.
2003: Moore Michael J; Mitrofanov Igor V; Valentini Stefanie S; Volkov Vjacheslav V; Kurbskiy Aleksey V; Zhimbey Elena N; Eglinton Lorraine B; Stegeman John J
Cytochrome P4501A expression, chemical contaminants and histopathology in roach, goby and sturgeon and chemical contaminants in sediments from the Caspian Sea, Lake Balkhash and the Ily River Delta, Kazakhstan.
Marine pollution bulletin 2003;46(1):107-19.
2002: Stegeman John J; Solow Andrew R; Goehl Thomas J
Enviromental health and the coastal zone.
Environmental health perspectives 2002;110(11):A660-1.
2002: Bard Shannon Mala; Woodin Bruce R; Stegeman John J
Expression of P-glycoprotein and cytochrome p450 1A in intertidal fish (Anoplarchus purpurescens) exposed to environmental contaminants.
Aquatic toxicology (Amsterdam, Netherlands) 2002;60(1-2):17-32.
2002: Bard Shannon Mala; Bello Susan M; Hahn Mark E; Stegeman John J
Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics.
Aquatic toxicology (Amsterdam, Netherlands) 2002;59(3-4):237-51.
2002: Hestermann Eli V; Stegeman John J; Hahn Mark E
Relationships among the cell cycle, cell proliferation, and aryl hydrocarbon receptor expression in PLHC-1 cells.
Aquatic toxicology (Amsterdam, Netherlands) 2002;58(3-4):201-13.
2002: Hestermann Eli V; Stegeman John J; Hahn Mark E
Serum withdrawal leads to reduced aryl hydrocarbon receptor expression and loss of cytochrome P4501A inducibility in PLHC-1 cells.
Biochemical pharmacology 2002;63(8):1405-14.
2002: Iwata Hisato; Yoshinari Kouichi; Negishi Masahiko; Stegeman John J
Species-specific responses of constitutively active receptor (CAR)-CYP2B coupling: lack of CYP2B inducer-responsive nuclear translocation of CAR in marine teleost, scup (Stenotomus chrysops).
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2002;131(4):501-10.
2002: Jewett Stephen C; Dean Thomas A; Woodin Bruce R; Hoberg Max K; Stegeman John J
Exposure to hydrocarbons 10 years after the Exxon Valdez oil spill: evidence from cytochrome P4501A expression and biliary FACs in nearshore demersal fishes.
Marine environmental research 2002;54(1):21-48.
2001: Cox R L; Mariano T; Heck D E; Laskin J D; Stegeman J J
Nitric oxide synthase sequences in the marine fish Stenotomus chrysops and the sea urchin Arbacia punctulata, and phylogenetic analysis of nitric oxide synthase calmodulin-binding domains.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2001;130(4):479-91.
2001: Verbrugge L A; Giesy J P; Verbrugge D A; Woodin B R; Stegeman J J
Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with beta-naphthoflavone or isosafrole.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2001;130(1):67-83.
2001: Schlezinger J J; Stegeman J J
Induction and suppression of cytochrome P450 1A by 3,3',4,4',5-pentachlorobiphenyl and its relationship to oxidative stress in the marine fish scup (Stenotomus chrysops).
Aquatic toxicology (Amsterdam, Netherlands) 2001;52(2):101-15.
2001: Bello S M; Franks D G; Stegeman J J; Hahn M E
Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes.
Toxicological sciences : an official journal of the Society of Toxicology 2001;60(1):77-91.
2001: Stegeman J J; Schlezinger J J; Craddock J E; Tillitt D E
Cytochrome P450 1A expression in midwater fishes: potential effects of chemical contaminants in remote oceanic zones.
Environmental science & technology 2001;35(1):54-62.
2001: Huang Y W; Stegeman J J; Woodin B R; Karasov W H
Immunohistochemical localization of cytochrome P4501A induced by 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in multiple organs of northern leopard frogs, Rana pipiens.
Environmental toxicology and chemistry / SETAC 2001;20(1):191-7.
2000: Hestermann E V; Stegeman J J; Hahn M E
Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency.
Toxicology and applied pharmacology 2000;168(2):160-72.
2000: Godard C A; Leaver M J; Said M R; Dickerson R L; George S; Stegeman J J
Identification of cytochrome P450 1B-like sequences in two teleost fish species (scup, Stenotomus chrysops and plaice, Pleuronectes platessa) and in a cetacean (striped dolphin, Stenella coeruleoalba).
Marine environmental research 2000;50(1-5):7-10.
2000: White R D; Shea D; Schlezinger J J; Hahn M E; Stegeman J J
In vitro metabolism of polychlorinated biphenyl congeners by beluga whale (Delphinapterus leucas) and pilot whale (Globicephala melas) and relationship to cytochrome P450 expression.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2000;126(3):267-84.
2000: Schlezinger J J; Stegeman J J
Dose and inducer-dependent induction of cytochrome P450 1A in endothelia of the eel, including in the swimbladder rete mirabile, a model microvascular structure.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(6):701-8.
2000: Schlezinger J J; Blickarz C E; Mann K K; Doerre S; Stegeman J J
Identification of NF-kappaB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists.
Chemico-biological interactions 2000;126(2):137-57.
2000: Iwata H; Stegeman J J
In situ RT-PCR detection of CYP1A mRNA in pharyngeal epithelium and chondroid cells from chemically untreated fish: involvement in vertebrate craniofacial skeletal development?
Biochemical and biophysical research communications 2000;271(1):130-7.
2000: Schlezinger J J; Keller J; Verbrugge L A; Stegeman J J
3,3',4,4'-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2000;125(3):273-86.
2000: Hestermann E V; Stegeman J J; Hahn M E
Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(2):316-25.
2000: Oleksiak M F; Wu S; Parker C; Karchner S I; Stegeman J J; Zeldin D C
Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns.
The Journal of biological chemistry 2000;275(4):2312-21.
1999: Schlezinger J J; White R D; Stegeman J J
Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As.
Molecular pharmacology 1999;56(3):588-97.
1998: Fent K; Woodin B R; Stegeman J J
Effects of triphenyltin and other organotins on hepatic monooxygenase system in fish.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1998;121(1-3):277-88.
1998: Morrison H G; Weil E J; Karchner S I; Sogin M L; Stegeman J J
Molecular cloning of CYP1A from the estuarine fish Fundulus heteroclitus and phylogenetic analysis of CYP1 genes: update with new sequences.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1998;121(1-3):231-40.
1998: Stegeman J J; Livingstone D R
Forms and functions of cytochrome P450.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1998;121(1-3):1-3.
1998: Hahn M E; Woodin B R; Stegeman J J; Tillitt D E
Aryl hydrocarbon receptor function in early vertebrates: inducibility of cytochrome P450 1A in agnathan and elasmobranch fish.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1998;120(1):67-75.
1998: Yawetz A; Woodin B R; Stegeman J J
Cytochromes P450 in liver of the turtle Chrysemys picta picta and the induction and partial purification of CYP1A-like proteins.
Biochimica et biophysica acta 1998;1381(1):12-26.
1998: Schlezinger J J; Parker C; Zeldin D C; Stegeman J J
Arachidonic acid metabolism in the marine fish Stenotomus chrysops (Scup) and the effects of cytochrome P450 1A inducers.
Archives of biochemistry and biophysics 1998;353(2):265-75.
1998: Cantrell S M; Joy-Schlezinger J; Stegeman J J; Tillitt D E; Hannink M
Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity.
Toxicology and applied pharmacology 1998;148(1):24-34.
1997: Celander M; Stegeman J J
Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A genes.
Biochemical and biophysical research communications 1997;236(2):306-12.
1997: White R D; Shea D; Stegeman J J
Metabolism of the aryl hydrocarbon receptor agonist 3,3',4,4'-tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(5):564-72.
1997: White R D; Shea D; Solow A R; Stegeman J J
Induction and post-transcriptional suppression of hepatic cytochrome P450 1A1 by 3,3',4,4'-tetrachlorobiphenyl.
Biochemical pharmacology 1997;53(7):1029-40.
1997: Celander M; Weisbrod R; Stegeman J J
Glucocorticoid potentiation of cytochrome P4501A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin in porcine and human endothelial cells in culture.
Biochemical and biophysical research communications 1997;232(3):749-53.
1997: Stegeman J J; Woodin B R; Singh H; Oleksiak M F; Celander M
Cytochromes P450 (CYP) in tropical fishes: catalytic activities, expression of multiple CYP proteins and high levels of microsomal P450 in liver of fishes from Bermuda.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1997;116(1):61-75.
1996: Kennedy S W; Lorenzen A; Jones S P; Hahn M E; Stegeman J J
Cytochrome P4501A induction in avian hepatocyte cultures: a promising approach for predicting the sensitivity of avian species to toxic effects of halogenated aromatic hydrocarbons.
Toxicology and applied pharmacology 1996;141(1):214-30.
1996: Moore M J; Stegeman J J
Hepatocyte vacuolation and autolytic changes in the liver of pilot whales, Globicephala melas, stranded on Cape Cod, MA, USA.
The Science of the total environment 1996;186(1-2):105-8.
1996: Celander M; Hahn M E; Stegeman J J
Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A.
Archives of biochemistry and biophysics 1996;329(1):113-22.
1995: Morrison H G; Oleksiak M F; Cornell N W; Sogin M L; Stegeman J J
Identification of cytochrome P-450 1A (CYP1A) genes from two teleost fish, toadfish (Opsanus tau) and scup (Stenotomus chrysops), and phylogenetic analysis of CYP1A genes.
The Biochemical journal 1995;308 ( Pt 1)():97-104.
1995: Stegeman J J; Hahn M E; Weisbrod R; Woodin B R; Joy J S; Najibi S; Cohen R A
Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells.
Molecular pharmacology 1995;47(2):296-306.
1994: Hahn M E; Stegeman J J
Regulation of cytochrome P4501A1 in teleosts: sustained induction of CYP1A1 mRNA, protein, and catalytic activity by 2,3,7,8-tetrachlorodibenzofuran in the marine fish Stenotomus chrysops.
Toxicology and applied pharmacology 1994;127(2):187-98.
1994: Kloepper-Sams P J; Stegeman J J
Turnover of hepatic microsomal cytochrome P4501A protein and heme in beta-naphthoflavone-induced Fundulus heteroclitus.
Molecular marine biology and biotechnology 1994;3(3):171-83.
1994: White R D; Hahn M E; Lockhart W L; Stegeman J J
Catalytic and immunochemical characterization of hepatic microsomal cytochromes P450 in beluga whale (Delphinapterus leucas).
Toxicology and applied pharmacology 1994;126(1):45-57.
1994: Hahn M E; Poland A; Glover E; Stegeman J J
Photoaffinity labeling of the Ah receptor: phylogenetic survey of diverse vertebrate and invertebrate species.
Archives of biochemistry and biophysics 1994;310(1):218-28.
1992: Smolowitz R M; Schultz M E; Stegeman J J
Cytochrome P4501A induction in tissues, including olfactory epithelium, of topminnows (Poeciliopsis spp.) by waterborne benzo[a]pyrene.
Carcinogenesis 1992;13(12):2395-402.
1992: Kloepper-Sams P J; Stegeman J J
Effects of temperature acclimation on the expression of hepatic cytochrome P4501A mRNA and protein in the fish Fundulus heteroclitus.
Archives of biochemistry and biophysics 1992;299(1):38-46.
1992: Van Veld P A; Vogelbein W K; Smolowitz R; Woodin B R; Stegeman J J
Cytochrome P450IA1 in hepatic lesions of a teleost fish (Fundulus heteroclitus) collected from a polycyclic aromatic hydrocarbon-contaminated site.
Carcinogenesis 1992;13(3):505-7.
1991: Stegeman J J; Smolowitz R M; Hahn M E
Immunohistochemical localization of environmentally induced cytochrome P450IA1 in multiple organs of the marine teleost Stenotomus chrysops (Scup).
Toxicology and applied pharmacology 1991;110(3):486-504.
1991: Gray E S; Woodin B R; Stegeman J J
Sex differences in hepatic monooxygenases in winter flounder (Pseudopleuronectes americanus) and scup (Stenotomus chrysops) and regulation of P450 forms by estradiol.
The Journal of experimental zoology 1991;259(3):330-42.
1991: Stegeman J J; Lech J J
Cytochrome P-450 monooxygenase systems in aquatic species: carcinogen metabolism and biomarkers for carcinogen and pollutant exposure.
Environmental health perspectives 1991;90():101-9.
1991: Smolowitz R M; Hahn M E; Stegeman J J
Immunohistochemical localization of cytochrome P-450IA1 induced by 3,3',4,4'-tetrachlorobiphenyl and by 2,3,7,8-tetrachlorodibenzoafuran in liver and extrahepatic tissues of the teleost Stenotomus chrysops (scup).
Drug metabolism and disposition: the biological fate of chemicals 1991;19(1):113-23.
1990: Stegeman J J; Woodin B R; Smolowitz R M
Structure, function and regulation of cytochrome P-450 forms in fish.
Biochemical Society transactions 1990;18(1):19-21.
1990: Pajor A M; Stegeman J J; Thomas P; Woodin B R
Feminization of the hepatic microsomal cytochrome P-450 system in brook trout by estradiol, testosterone, and pituitary factors.
The Journal of experimental zoology 1990;253(1):51-60.
1989: Stegeman J J; Miller M R; Hinton D E
Cytochrome P450IA1 induction and localization in endothelium of vertebrate (teleost) heart.
Molecular pharmacology 1989;36(5):723-9.
1989: Gooch J W; Elskus A A; Kloepper-Sams P J; Hahn M E; Stegeman J J
Effects of ortho- and non-ortho-substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup (Stenotomus chrysops).
Toxicology and applied pharmacology 1989;98(3):422-33.
1989: Kloepper-Sams P J; Stegeman J J
The temporal relationships between P450E protein content, catalytic activity, and mRNA levels in the teleost Fundulus heteroclitus following treatment with beta-naphthoflavone.
Archives of biochemistry and biophysics 1989;268(2):525-35.
1988: Singh H; Griffith R W; Takahashi A; Kawauchi H; Thomas P; Stegeman J J
Regulation of gonadal steroidogenesis in Fundulus heteroclitus by recombinant salmon growth hormone and purified salmon prolactin.
General and comparative endocrinology 1988;72(1):144-53.
1988: van Veld P A; Stegeman J J; Woodin B R; Patton J S; Lee R F
Induction of monooxygenase activity in the intestine of spot (Leiostomus xanthurus), a marine teleost, by dietary polycyclic aromatic hydrocarbons.
Drug metabolism and disposition: the biological fate of chemicals 1988;16(5):659-65.
1987: Goddard K A; Schultz R J; Stegeman J J
Uptake, toxicity, and distribution of benzo[a]pyrene and monooxygenase induction in the topminnows Poeciliopsis monacha and Poeciliopsis lucida.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(4):449-55.
1987: Stegeman J J; Kloepper-Sams P J
Cytochrome P-450 isozymes and monooxygenase activity in aquatic animals.
Environmental health perspectives 1987;71():87-95.
1987: Kloepper-Sams P J; Park S S; Gelboin H V; Stegeman J J
Specificity and cross-reactivity of monoclonal and polyclonal antibodies against cytochrome P-450E of the marine fish scup.
Archives of biochemistry and biophysics 1987;253(1):268-78.
1986: Klotz A V; Stegeman J J; Woodin B R; Snowberger E A; Thomas P E; Walsh C
Cytochrome P-450 isozymes from the marine teleost Stenotomus chrysops: their roles in steroid hydroxylation and the influence of cytochrome b5.
Archives of biochemistry and biophysics 1986;249(2):326-38.
1986: Park S S; Miller H; Klotz A V; Kloepper-Sams P J; Stegeman J J; Gelboin H V
Monoclonal antibodies to liver microsomal cytochrome P-450E of the marine fish Stenotomus chrysops (scup): cross reactivity with 3-methylcholanthrene induced rat cytochrome P-450.
Archives of biochemistry and biophysics 1986;249(2):339-50.
1986: Cornell N W; Stegeman J J; Kerich M J; Woodin B R
Metabolite and enzyme contents of freeze-clamped liver of the marine fish Stenotomus chrysops.
Comparative biochemistry and physiology. B, Comparative biochemistry 1986;85(3):669-74.
1984: Klotz A V; Stegeman J J; Walsh C
An alternative 7-ethoxyresorufin O-deethylase activity assay: a continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity.
Analytical biochemistry 1984;140(1):138-45.
1984: Stegeman J J; Woodin B R; Binder R L
Patterns of benzo[a]pyrene metabolism by varied species, organs, and developmental stages of fish.
National Cancer Institute monograph 1984;65():371-7.
1983: Klotz A V; Stegeman J J; Walsh C
An aryl hydrocarbon hydroxylating hepatic cytochrome P-450 from the marine fish Stenotomus chrysops.
Archives of biochemistry and biophysics 1983;226(2):578-92.
1982: Stegeman J J; Woodin B R; Klotz A V; Wolke R E; Orme-Johnson N R
Cytochrome P-450 and monooxygenase activity in cardiac microsomes from the fish Stenotomus chrysops.
Molecular pharmacology 1982;21(2):517-26.
1980: Stegeman J J; Woodin B R
The metabolism of alpha-naphthoflavone (7,8-benzoflavone) by hepatic microsomes from the marine fish Stenotomus versicolor.
Biochemical and biophysical research communications 1980;95(1):328-33.

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