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Alexander Stegh

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Publications

TOP 3
Alexander H Stegh
Toward personalized cancer nanomedicine - past, present, and future.
Fotini M Kouri; Samuel A Jensen; Alexander H Stegh
The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond.
Alexander H Stegh
Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils.

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All Publications

2013: Alexander H Stegh
Toward personalized cancer nanomedicine - past, present, and future.
Integrative biology : quantitative biosciences from nano to macro 2013;5(1):48-65.
2012: Fotini M Kouri; Samuel A Jensen; Alexander H Stegh
The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond.
TheScientificWorldJournal 2012;2012():838916.
2012: Alexander H Stegh
Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils.
Expert opinion on therapeutic targets 2012;16(1):67-83.
2011: Zhihu Ding; Chang-Jiun Wu; Gerald Chu; Yonghong Xiao; Dennis Ho; Jingfang Zhang; Samuel R Perry; Emma S Labrot; Xiaoqiu Wu; Rosina Lis; Yujin Hoshida; David Hiller; Baoli Hu; Shan Jiang; Hongwu Zheng; Alexander H Stegh; Kenneth L Scott; Sabina Signoretti; Nabeel Bardeesy; Y Alan Wang; David E Hill; Todd R Golub; Meir J Stampfer; Wing H Wong; Massimo Loda; Lorelei Mucci; Lynda Chin; Ronald A DePinho
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.
Nature 2011;470(7333):269-73.
2011: Alexander H Stegh; Ronald A DePinho
Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma.
Cell cycle (Georgetown, Tex.) 2011;10(1):33-8.
2010: Alexander H Stegh; Cameron Brennan; John A Mahoney; Kristin L Forloney; Harry T Jenq; Janina P Luciano; Alexei Protopopov; Lynda Chin; Ronald A DePinho
Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor.
Genes & development 2010;24(19):2194-204.
2008: Alexander H Stegh; Lynda Chin; David N Louis; Ronald A DePinho
What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator.
Cell cycle (Georgetown, Tex.) 2008;7(18):2833-9.
2008: Alexander H Stegh; Santosh kesari; John E Mahoney; Harry T Jenq; Kristin L Forloney; Alexei Protopopov; David N Louis; Lynda Chin; Ronald A DePinho
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10703-8.
2007: Frank B Furnari; Tim Fenton; Robert M Bachoo; Akitake Mukasa; Jayne M Stommel; Alexander H Stegh; William C Hahn; Keith L Ligon; David N Louis; Cameron Brennan; Lynda Chin; Ronald A DePinho; Webster K Cavenee
Malignant astrocytic glioma: genetics, biology, and paths to treatment.
Genes & development 2007;21(21):2683-710.
2007: Jayne M Stommel; Alec C Kimmelman; Haoqiang Ying; Roustem Nabioullin; Aditya H Ponugoti; Ruprecht Wiedemeyer; Alexander H Stegh; James E Bradner; Keith L Ligon; Cameron Brennan; Lynda Chin; Ronald A DePinho
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.
Science (New York, N.Y.) 2007;318(5848):287-90.
2007: Alexander H Stegh; Hyunggee Kim; Robert M Bachoo; Kristin L Forloney; Jean Zhang; Harald Schulze; Kevin Park; Gregory J Hannon; Junying Yuan; David N Louis; Ronald A DePinho; Lynda Chin
Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma.
Genes & development 2007;21(1):98-111.
2002: Justine C Lee; Olaf Schickling; Alexander H Stegh; Robert Glen Oshima; David Dinsdale; Gerald M Cohen; Marcus E Peter
DEDD regulates degradation of intermediate filaments during apoptosis.
The Journal of cell biology 2002;158(6):1051-66.
2002: Alexander H Stegh; Bryan C Barnhart; Jörg Volkland; Alicia Algeciras-Schimnich; Ning Ke; John C Reed; Marcus E Peter
Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein.
The Journal of biological chemistry 2002;277(6):4351-60.
2001: Olaf Schickling; Alexander H Stegh; John Byrd; Marcus E Peter
Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription.
Cell death and differentiation 2001;8(12):1157-68.
2001: Alexander H Stegh; Marcus E Peter
Apoptosis and caspases.
Cardiology clinics 2001;19(1):13-29.
2000: Alexander H Stegh; Harald Herrmann; Stefan Lampel; D Weisenberger; Kerstin Andrä; M Seper; Gerhard Wiche; Peter H Krammer; Marcus E Peter
Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.
Molecular and cellular biology 2000;20(15):5665-79.
1998: Alexander H Stegh; Olaf Schickling; A Ehret; C Scaffidi; C Peterhänsel; Thomas G Hofmann; Ingrid Grummt; Peter H Krammer; Marcus E Peter
DEDD, a novel death effector domain-containing protein, targeted to the nucleolus.
The EMBO journal 1998;17(20):5974-86.