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Gary Bokoch

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
18
Knaus, Ulla
16
Bohl, Benjamin
12
Chuang, Tsung-Hsien
10
DerMardirossian, Céline
7
Jesaitis, Algirdas
7
King, Charles
7
Quilliam, Lawrence
7
Zenke, Frank
6
Sanders, Luraynne
6
Schwartz, Martin
6
Nalbant, Perihan
6
Diebold, Becky
6
Daniels, RH
5
Benard, Valerie
5
Curnutte, John

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Publications

TOP 3
Bokoch Gary M; Diebold Becky; Kim Jun-Sub; Gianni Davide
Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases.
Nalbant Perihan; Chang Yuan-Chen; Birkenfeld Jörg; Chang Zee-Fen; Bokoch Gary M
Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.
Zhang Hui; Sun Chunxiang; Glogauer Michael; Bokoch Gary M
Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2.

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All Publications

2009: Bokoch Gary M; Diebold Becky; Kim Jun-Sub; Gianni Davide
Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases.
Antioxidants & redox signaling 2009;11(10):2429-41.
2009: Nalbant Perihan; Chang Yuan-Chen; Birkenfeld Jörg; Chang Zee-Fen; Bokoch Gary M
Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.
Molecular biology of the cell 2009;20(18):4070-82.
2009: Zhang Hui; Sun Chunxiang; Glogauer Michael; Bokoch Gary M
Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2718-28.
2009: Kim Jun-Sub; Huang Timothy Y; Bokoch Gary M
Reactive oxygen species regulate a slingshot-cofilin activation pathway.
Molecular biology of the cell 2009;20(11):2650-60.
2009: Gianni Davide; Diaz Begoña; Taulet Nicolas; Fowler Bruce; Courtneidge Sara A; Bokoch Gary M
Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity.
Science signaling 2009;2(88):ra54.
2008: Huber Christoph; Mårtensson Annica; Bokoch Gary M; Nemazee David; Gavin Amanda L
FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles.
The Journal of biological chemistry 2008;283(49):34002-12.
2008: Huang Timothy Y; Minamide Laurie S; Bamburg James R; Bokoch Gary M
Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation.
Developmental cell 2008;15(5):691-703.
2008: Chrencik Jill E; Brooun Alexei; Zhang Hui; Mathews Irimpan I; Hura Greg L; Foster Scott A; Perry J Jefferson P; Streiff Markus; Ramage Paul; Widmer Hans; Bokoch Gary M; Tainer John A; Weckbecker Gisbert; Kuhn Peter
Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.
Journal of molecular biology 2008;380(5):828-43.
2008: Gianni Davide; Bohl Ben; Courtneidge Sara A; Bokoch Gary M
The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1.
Molecular biology of the cell 2008;19(7):2984-94.
2008: Khan Adil A; Mao Xiao Ou; Banwait Surita; DerMardirossian Celine M; Bokoch Gary M; Jin Kunlin; Greenberg David A
Regulation of hypoxic neuronal death signaling by neuroglobin.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(6):1737-47.
2008: Birukova Anna A; Zagranichnaya Tatiana; Alekseeva Elena; Bokoch Gary M; Birukov Konstantin G
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
Journal of cellular physiology 2008;215(3):715-24.
2008: Birkenfeld Jörg; Nalbant Perihan; Yoon Soon-Hee; Bokoch Gary M
Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?
Trends in cell biology 2008;18(5):210-9.
2008: Kao Yu-Ya; Gianni Davide; Bohl Benjamin; Taylor Ross M; Bokoch Gary M
Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism.
The Journal of biological chemistry 2008;283(19):12736-46.
2008: Chang Yuan-Chen; Nalbant Perihan; Birkenfeld Jörg; Chang Zee-Fen; Bokoch Gary M
GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA.
Molecular biology of the cell 2008;19(5):2147-53.
2008: Bokoch Gary M
PAK'n it in: identification of a selective PAK inhibitor.
Chemistry & biology 2008;15(4):305-6.
2008: Lim Yangmi; Lim Ssang-Taek; Tomar Alok; Gardel Margaret; Bernard-Trifilo Joie A; Chen Xiao Lei; Uryu Sean A; Canete-Soler Rafaela; Zhai Jinbin; Lin Hong; Schlaepfer William W; Nalbant Perihan; Bokoch Gary; Ilic Dusko; Waterman-Storer Clare; Schlaepfer David D
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.
The Journal of cell biology 2008;180(1):187-203.
2007: Delorme Violaine; Machacek Matthias; DerMardirossian Céline; Anderson Karen L; Wittmann Torsten; Hanein Dorit; Waterman-Storer Clare; Danuser Gaudenz; Bokoch Gary M
Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks.
Developmental cell 2007;13(5):646-62.
2007: Kim Jun-Sub; Diebold Becky A; Babior Bernard M; Knaus Ulla G; Bokoch Gary M
Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding.
The Journal of biological chemistry 2007;282(48):34787-800.
2007: Zoudilova Maria; Kumar Puneet; Ge Lan; Wang Ping; Bokoch Gary M; DeFea Kathryn A
Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2.
The Journal of biological chemistry 2007;282(28):20634-46.
2007: Birkenfeld Jörg; Nalbant Perihan; Bohl Benjamin P; Pertz Olivier; Hahn Klaus M; Bokoch Gary M
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.
Developmental cell 2007;12(5):699-712.
2007: Zhao Tieming; Nalbant Perihan; Hoshino Mikio; Dong Xuemei; Wu Dianqing; Bokoch Gary M
Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function.
Journal of leukocyte biology 2007;81(4):1127-36.
2007: Zhao Tieming; Bokoch Gary M
Transduction of proteins into intact neutrophils.
Methods in molecular biology (Clifton, N.J.) 2007;412():115-23.
2007: Knaus Ulla G; Bamberg Alison; Bokoch Gary M
Rac and Rap GTPase activation assays.
Methods in molecular biology (Clifton, N.J.) 2007;412():59-67.
2007: Quinn Mark T; DeLeo Frank R; Bokoch Gary M
Neutrophil methods and protocols. Preface.
Methods in molecular biology (Clifton, N.J.) 2007;412():vii-viii.
2006: DerMardirossian Céline; Rocklin Gabriel; Seo Ji-Yeon; Bokoch Gary M
Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling.
Molecular biology of the cell 2006;17(11):4760-8.
2006: Belvindrah Richard; Nalbant Perihan; Ding Sheng; Wu Chuanyue; Bokoch Gary M; Müller Ulrich
Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development.
Molecular and cellular neurosciences 2006;33(2):109-25.
2006: Pestonjamasp Kersi N; Forster Carol; Sun Chunxiang; Gardiner Elisabeth M; Bohl Ben; Weiner Orion; Bokoch Gary M; Glogauer Michael
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis.
Blood 2006;108(8):2814-20.
2006: Bokoch Gary M; Zhao Tieming
Regulation of the phagocyte NADPH oxidase by Rac GTPase.
Antioxidants & redox signaling 2006;8(9-10):1533-48.
2006: Crawford Matthew A; Aylott Caroline V; Bourdeau Raymond W; Bokoch Gary M
Bacillus anthracis toxins inhibit human neutrophil NADPH oxidase activity.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7557-65.
2006: DeCathelineau Aimee M; Bokoch Gary M
Peptide inhibitors MAP the way towards fighting anthrax pathogenesis.
The Biochemical journal 2006;395(1):e1-3.
2006: Birukova Anna A; Adyshev Djanybek; Gorshkov Boris; Bokoch Gary M; Birukov Konstantin G; Verin Alexander D
GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction.
American journal of physiology. Lung cellular and molecular physiology 2006;290(3):L540-8.
2006: Huang Timothy Y; DerMardirossian Céline; Bokoch Gary M
Cofilin phosphatases and regulation of actin dynamics.
Current opinion in cell biology 2006;18(1):26-31.
2006: Stofega Mary; DerMardirossian Celine; Bokoch Gary M
Affinity-based assay of Rho guanosine triphosphatase activation.
Methods in molecular biology (Clifton, N.J.) 2006;332():269-79.
2006: DerMardirossian Celine M; Bokoch Gary M
Phosphorylation of RhoGDI by p21-activated kinase 1.
Methods in enzymology 2006;406():80-90.
2005: Dong Xuemei; Mo Zhicheng; Bokoch Gary; Guo Caiying; Li Zhong; Wu Dianqing
P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils.
Current biology : CB 2005;15(20):1874-9.
2005: DerMardirossian Céline; Bokoch Gary M
GDIs: central regulatory molecules in Rho GTPase activation.
Trends in cell biology 2005;15(7):356-63.
2005: Zhao Tieming; Bokoch Gary M
Critical role of proline-rich tyrosine kinase 2 in reversion of the adhesion-mediated suppression of reactive oxygen species generation by human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):8049-55.
2005: Yuan Zeng-qiang; Kim Donghwa; Kaneko Satoshi; Sussman Melissa; Bokoch Gary M; Kruh Gary D; Nicosia Santo V; Testa Joseph R; Cheng Jin Q
ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival.
The Journal of biological chemistry 2005;280(22):21483-90.
2005: Makino Ayako; Glogauer Michael; Bokoch Gary M; Chien Shu; Schmid-Schönbein Geert W
Control of neutrophil pseudopods by fluid shear: role of Rho family GTPases.
American journal of physiology. Cell physiology 2005;288(4):C863-71.
2005: Bokoch Gary M
Regulation of innate immunity by Rho GTPases.
Trends in cell biology 2005;15(3):163-71.
2005: Gohla Antje; Birkenfeld Jörg; Bokoch Gary M
Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics.
Nature cell biology 2005;7(1):21-9.
2005: Diebold B A; Bokoch G M
Rho GTPases and the control of the oxidative burst in polymorphonuclear leukocytes.
Current topics in microbiology and immunology 2005;291():91-111.
2004: Birukov Konstantin G; Bochkov Valery N; Birukova Anna A; Kawkitinarong Kamon; Rios Alexander; Leitner Alexander; Verin Alexander D; Bokoch Gary M; Leitinger Norbert; Garcia Joe G N
Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac.
Circulation research 2004;95(9):892-901.
2004: DerMardirossian Céline; Schnelzer Andreas; Bokoch Gary M
Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase.
Molecular cell 2004;15(1):117-27.
2004: Diebold Becky A; Fowler Bruce; Lu Justine; Dinauer Mary C; Bokoch Gary M
Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species.
The Journal of biological chemistry 2004;279(27):28136-42.
2004: Stofega Mary R; Sanders Luraynne C; Gardiner Elisabeth M; Bokoch Gary M
Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions.
Molecular biology of the cell 2004;15(6):2965-77.
2004: Zenke Frank T; Krendel Mira; DerMardirossian Celine; King Charles C; Bohl Benjamin P; Bokoch Gary M
p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.
The Journal of biological chemistry 2004;279(18):18392-400.
2004: Wittmann Torsten; Bokoch Gary M; Waterman-Storer Clare M
Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1.
The Journal of biological chemistry 2004;279(7):6196-203.
2004: Li Wei; Fan Jianhua; Chen Mei; Guan Shengxi; Sawcer David; Bokoch Gary M; Woodley David T
Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB.
Molecular biology of the cell 2004;15(1):294-309.
2004: Schrantz Nicolas; da Silva Correia Jean; Fowler Bruce; Ge Qingyuan; Sun Zijie; Bokoch Gary M
Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.
The Journal of biological chemistry 2004;279(3):1922-31.
2003: Zhao Tieming; Benard Valerie; Bohl Benjamin P; Bokoch Gary M
The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophils.
The Journal of clinical investigation 2003;112(11):1732-40.
2003: Zhou Guo-Lei; Zhuo Ya; King Charles C; Fryer Benjamin H; Bokoch Gary M; Field Jeffrey
Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration.
Molecular and cellular biology 2003;23(22):8058-69.
2003: Bokoch Gary M; Knaus Ulla G
NADPH oxidases: not just for leukocytes anymore!
Trends in biochemical sciences 2003;28(9):502-8.
2003: Li Quanwen; Ho Chi S; Marinescu Vlad; Bhatti Humaa; Bokoch Gary M; Ernst Stephen A; Holz Ronald W; Stuenkel Edward L
Facilitation of Ca(2+)-dependent exocytosis by Rac1-GTPase in bovine chromaffin cells.
The Journal of physiology 2003;550(Pt 2):431-45.
2003: Wittmann Torsten; Bokoch Gary M; Waterman-Storer Clare M
Regulation of leading edge microtubule and actin dynamics downstream of Rac1.
The Journal of cell biology 2003;161(5):845-51.
2003: Rudrabhatla Rajyalakshmi S; Sukumaran Sunil K; Bokoch Gary M; Prasadarao Nemani V
Modulation of myosin light-chain phosphorylation by p21-activated kinase 1 in Escherichia coli invasion of human brain microvascular endothelial cells.
Infection and immunity 2003;71(5):2787-97.
2003: Puto Lorena A; Pestonjamasp Kersi; King Charles C; Bokoch Gary M
p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling.
The Journal of biological chemistry 2003;278(11):9388-93.
2003: Bokoch Gary M
Biology of the p21-activated kinases.
Annual review of biochemistry 2003;72():743-81.
2002: Gardiner Elisabeth M; Pestonjamasp Kersi N; Bohl Benjamin P; Chamberlain Chester; Hahn Klaus M; Bokoch Gary M
Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis.
Current biology : CB 2002;12(23):2029-34.
2002: Berrier Allison L; Martinez Robert; Bokoch Gary M; LaFlamme Susan E
The integrin beta tail is required and sufficient to regulate adhesion signaling to Rac1.
Journal of cell science 2002;115(Pt 22):4285-91.
2002: Shin Eun-Young; Shin Kyung-Sun; Lee Chan-Soo; Woo Kyung-Nam; Quan Song-Hua; Soung Nak-Kyun; Kim Young Gyu; Cha Choong Ik; Kim Seung-Ryul; Park Dongeun; Bokoch Gary M; Kim Eung-Gook
Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth.
The Journal of biological chemistry 2002;277(46):44417-30.
2002: Gohla Antje; Bokoch Gary M
14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin.
Current biology : CB 2002;12(19):1704-10.
2002: Bokoch Gary M; Diebold Becky A
Current molecular models for NADPH oxidase regulation by Rac GTPase.
Blood 2002;100(8):2692-6.
2002: Allen Melissa P; Xu Mei; Linseman Daniel A; Pawlowski John E; Bokoch Gary M; Heidenreich Kim A; Wierman Margaret E
Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway.
The Journal of biological chemistry 2002;277(41):38133-40.
2002: Bokoch Gary M
Microbial killing: hold the bleach and pass the salt!
Nature immunology 2002;3(4):340-2.
2002: Krendel Mira; Zenke Frank T; Bokoch Gary M
Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton.
Nature cell biology 2002;4(4):294-301.
2002: Diakonova Maria; Bokoch Gary; Swanson Joel A
Dynamics of cytoskeletal proteins during Fcgamma receptor-mediated phagocytosis in macrophages.
Molecular biology of the cell 2002;13(2):402-11.
2002: Benard Valerie; Bokoch Gary M
Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods.
Methods in enzymology 2002;345():349-59.
2001: DerMardirossian C; Bokoch G M
Regulation of cell function by Rho GTPases.
Drug news & perspectives 2001;14(7):389-95.
2001: Lee J E; Bokoch G; Liang B T
A novel cardioprotective role of RhoA: new signaling mechanism for adenosine.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):1886-94.
2001: Golovanov A P; Hawkins D; Barsukov I; Badii R; Bokoch G M; Lian L Y; Roberts G C
Structural consequences of site-directed mutagenesis in flexible protein domains: NMR characterization of the L(55,56)S mutant of RhoGDI.
European journal of biochemistry / FEBS 2001;268(8):2253-60.
2001: Diebold B A; Bokoch G M
Molecular basis for Rac2 regulation of phagocyte NADPH oxidase.
Nature immunology 2001;2(3):211-5.
2001: Golovanov A P; Chuang T H; DerMardirossian C; Barsukov I; Hawkins D; Badii R; Bokoch G M; Lian L Y; Roberts G C
Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI.
Journal of molecular biology 2001;305(1):121-35.
2000: King C C; Gardiner E M; Zenke F T; Bohl B P; Newton A C; Hemmings B A; Bokoch G M
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).
The Journal of biological chemistry 2000;275(52):41201-9.
2000: Kraynov V S; Chamberlain C; Bokoch G M; Schwartz M A; Slabaugh S; Hahn K M
Localized Rac activation dynamics visualized in living cells.
Science (New York, N.Y.) 2000;290(5490):333-7.
2000: Dharmawardhane S; Schürmann A; Sells M A; Chernoff J; Schmid S L; Bokoch G M
Regulation of macropinocytosis by p21-activated kinase-1.
Molecular biology of the cell 2000;11(10):3341-52.
2000: King C C; Zenke F T; Dawson P E; Dutil E M; Newton A C; Hemmings B A; Bokoch G M
Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.
The Journal of biological chemistry 2000;275(24):18108-13.
2000: Subauste M C; Von Herrath M; Benard V; Chamberlain C E; Chuang T H; Chu K; Bokoch G M; Hahn K M
Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas.
The Journal of biological chemistry 2000;275(13):9725-33.
2000: Lian L Y; Barsukov I; Golovanov A P; Hawkins D I; Badii R; Sze K H; Keep N H; Bokoch G M; Roberts G C
Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1.
Structure (London, England : 1993) 2000;8(1):47-55.
2000: Schürmann A; Mooney A F; Sanders L C; Sells M A; Wang H G; Reed J C; Bokoch G M
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.
Molecular and cellular biology 2000;20(2):453-61.
2000: King C C; Sanders L C; Bokoch G M
In vivo activity of wild-type and mutant PAKs.
Methods in enzymology 2000;325():315-27.
2000: Bokoch G M
Regulation of cell function by Rho family GTPases.
Immunologic research 2000;21(2-3):139-48.
1999: Kiosses W B; Daniels R H; Otey C; Bokoch G M; Schwartz M A
A role for p21-activated kinase in endothelial cell migration.
The Journal of cell biology 1999;147(4):831-44.
1999: Zenke F T; King C C; Bohl B P; Bokoch G M
Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity.
The Journal of biological chemistry 1999;274(46):32565-73.
1999: Edwards D C; Sanders L C; Bokoch G M; Gill G N
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.
Nature cell biology 1999;1(5):253-9.
1999: Dharmawardhane S; Brownson D; Lennartz M; Bokoch G M
Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils.
Journal of leukocyte biology 1999;66(3):521-7.
1999: Daniels R H; Bokoch G M
p21-activated protein kinase: a crucial component of morphological signaling?
Trends in biochemical sciences 1999;24(9):350-5.
1999: Benard V; Bokoch G M; Diebold B A
Potential drug targets: small GTPases that regulate leukocyte function.
Trends in pharmacological sciences 1999;20(9):365-70.
1999: Benard V; Bohl B P; Bokoch G M
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases.
The Journal of biological chemistry 1999;274(19):13198-204.
1999: Sanders L C; Matsumura F; Bokoch G M; de Lanerolle P
Inhibition of myosin light chain kinase by p21-activated kinase.
Science (New York, N.Y.) 1999;283(5410):2083-5.
1999: Daniels R H; Zenke F T; Bokoch G M
alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms.
The Journal of biological chemistry 1999;274(10):6047-50.
1998: Li E; Stupack D; Bokoch G M; Nemerow G R
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases.
Journal of virology 1998;72(11):8806-12.
1998: Knaus U G; Bokoch G M
The p21Rac/Cdc42-activated kinases (PAKs).
The international journal of biochemistry & cell biology 1998;30(8):857-62.
1998: Price L S; Leng J; Schwartz M A; Bokoch G M
Activation of Rac and Cdc42 by integrins mediates cell spreading.
Molecular biology of the cell 1998;9(7):1863-71.
1998: Zhou K; Wang Y; Gorski J L; Nomura N; Collard J; Bokoch G M
Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42.
The Journal of biological chemistry 1998;273(27):16782-6.
1998: Bokoch G M; Reilly A M; Daniels R H; King C C; Olivera A; Spiegel S; Knaus U G
A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.
The Journal of biological chemistry 1998;273(14):8137-44.
1998: Pan Z K; Ye R D; Christiansen S C; Jagels M A; Bokoch G M; Zuraw B L
Role of the Rho GTPase in bradykinin-stimulated nuclear factor-kappaB activation and IL-1beta gene expression in cultured human epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):3038-45.
1998: Daniels R H; Hall P S; Bokoch G M
Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells.
The EMBO journal 1998;17(3):754-64.
1998: Rudel T; Zenke F T; Chuang T H; Bokoch G M
p21-activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):7-11.
1997: Chuang T H; Hahn K M; Lee J D; Danley D E; Bokoch G M
The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes.
Molecular biology of the cell 1997;8(9):1687-98.
1997: Dharmawardhane S; Sanders L C; Martin S S; Daniels R H; Bokoch G M
Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells.
The Journal of cell biology 1997;138(6):1265-78.
1997: Zigmond S H; Joyce M; Borleis J; Bokoch G M; Devreotes P N
Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42.
The Journal of cell biology 1997;138(2):363-74.
1997: Rudel T; Bokoch G M
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2.
Science (New York, N.Y.) 1997;276(5318):1571-4.
1997: Sells M A; Knaus U G; Bagrodia S; Ambrose D M; Bokoch G M; Chernoff J
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.
Current biology : CB 1997;7(3):202-10.
1997: Dharmawardhane S; Bokoch G M
Rho GTPases and leukocyte cytoskeletal regulation.
Current opinion in hematology 1997;4(1):12-8.
1997: Xu X; Wang Y; Barry D C; Chanock S J; Bokoch G M
Guanine nucleotide binding properties of Rac2 mutant proteins and analysis of the responsiveness to guanine nucleotide dissociation stimulator.
Biochemistry 1997;36(3):626-32.
1996: Bokoch G M; Wang Y; Bohl B P; Sells M A; Quilliam L A; Knaus U G
Interaction of the Nck adapter protein with p21-activated kinase (PAK1).
The Journal of biological chemistry 1996;271(42):25746-9.
1996: Ptasznik A; Prossnitz E R; Yoshikawa D; Smrcka A; Traynor-Kaplan A E; Bokoch G M
A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils.
The Journal of biological chemistry 1996;271(41):25204-7.
1996: Ding J; Knaus U G; Lian J P; Bokoch G M; Badwey J A
The renaturable 69- and 63-kDa protein kinases that undergo rapid activation in chemoattractant-stimulated guinea pig neutrophils are p21-activated kinases.
The Journal of biological chemistry 1996;271(40):24869-73.
1996: Bokoch G M
Interplay between Ras-related and heterotrimeric GTP binding proteins: lifestyles of the BIG and little.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(11):1290-5.
1996: Danley D E; Chuang T H; Bokoch G M
Defective Rho GTPase regulation by IL-1 beta-converting enzyme-mediated cleavage of D4 GDP dissociation inhibitor.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(2):500-3.
1996: Lamaze C; Chuang T H; Terlecky L J; Bokoch G M; Schmid S L
Regulation of receptor-mediated endocytosis by Rho and Rac.
Nature 1996;382(6587):177-9.
1996: Bokoch G M; Vlahos C J; Wang Y; Knaus U G; Traynor-Kaplan A E
Rac GTPase interacts specifically with phosphatidylinositol 3-kinase.
The Biochemical journal 1996;315 ( Pt 3)():775-9.
1996: Na S; Chuang T H; Cunningham A; Turi T G; Hanke J H; Bokoch G M; Danley D E
D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis.
The Journal of biological chemistry 1996;271(19):11209-13.
1996: Ren X D; Bokoch G M; Traynor-Kaplan A; Jenkins G H; Anderson R A; Schwartz M A
Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.
Molecular biology of the cell 1996;7(3):435-42.
1995: Zhang S; Han J; Sells M A; Chernoff J; Knaus U G; Ulevitch R J; Bokoch G M
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.
The Journal of biological chemistry 1995;270(41):23934-6.
1995: Chuang T H; Xu X; Kaartinen V; Heisterkamp N; Groffen J; Bokoch G M
Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10282-6.
1995: Bokoch G M
Chemoattractant signaling and leukocyte activation.
Blood 1995;86(5):1649-60.
1995: Ptasznik A; Traynor-Kaplan A; Bokoch G M
G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexes.
The Journal of biological chemistry 1995;270(34):19969-73.
1995: Knaus U G; Morris S; Dong H J; Chernoff J; Bokoch G M
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors.
Science (New York, N.Y.) 1995;269(5221):221-3.
1995: Dorseuil O; Quinn M T; Bokoch G M
Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors.
Journal of leukocyte biology 1995;58(1):108-13.
1995: Prossnitz E R; Schreiber R E; Bokoch G M; Ye R D
Binding of low affinity N-formyl peptide receptors to G protein. Characterization of a novel inactive receptor intermediate.
The Journal of biological chemistry 1995;270(18):10686-94.
1995: Quinn M T; Bokoch G M
Measurement of Rac translocation from cytosol to membranes in activated neutrophils.
Methods in enzymology 1995;256():256-67.
1995: Knaus U G; Bokoch G M
Purification of Rac2 from human neutrophils.
Methods in enzymology 1995;256():25-32.
1994: Bokoch G M; Bohl B P; Chuang T H
Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.
The Journal of biological chemistry 1994;269(50):31674-9.
1994: Heyworth P G; Bohl B P; Bokoch G M; Curnutte J T
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.
The Journal of biological chemistry 1994;269(49):30749-52.
1994: Chuang T H; Xu X; Quilliam L A; Bokoch G M
SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism.
The Biochemical journal 1994;303 ( Pt 3)():761-7.
1994: Chong L D; Traynor-Kaplan A; Bokoch G M; Schwartz M A
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells.
Cell 1994;79(3):507-13.
1994: Xu X; Barry D C; Settleman J; Schwartz M A; Bokoch G M
Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac.
The Journal of biological chemistry 1994;269(38):23569-74.
1994: Maly F E; Quilliam L A; Dorseuil O; Der C J; Bokoch G M
Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes.
The Journal of biological chemistry 1994;269(29):18743-6.
1994: Bokoch G M
Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins.
Current opinion in cell biology 1994;6(2):212-8.
1994: Bokoch G M; Knaus U G
The role of small GTP-binding proteins in leukocyte function.
Current opinion in immunology 1994;6(1):98-105.
1994: Bokoch G M; Knaus U G
Ras-related GTP-binding proteins and leukocyte signal transduction.
Current opinion in hematology 1994;1(1):53-60.
1994: Schreiber R E; Prossnitz E R; Ye R D; Cochrane C G; Bokoch G M
Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides.
The Journal of biological chemistry 1994;269(1):326-31.
1993: Chuang T H; Bohl B P; Bokoch G M
Biologically active lipids are regulators of Rac.GDI complexation.
The Journal of biological chemistry 1993;268(35):26206-11.
1993: Heyworth P G; Knaus U G; Settleman J; Curnutte J T; Bokoch G M
Regulation of NADPH oxidase activity by Rac GTPase activating protein(s).
Molecular biology of the cell 1993;4(11):1217-23.
1993: Bokoch G M
Regulation of phagocyte function by low molecular weight GTP-binding proteins.
European journal of haematology 1993;51(5):313-7.
1993: Quinn M T; Evans T; Loetterle L R; Jesaitis A J; Bokoch G M
Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.
The Journal of biological chemistry 1993;268(28):20983-7.
1993: Bokoch G M; Der C J
Emerging concepts in the Ras superfamily of GTP-binding proteins.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(9):750-9.
1993: Schreiber R E; Prossnitz E R; Ye R D; Cochrane C G; Jesaitis A J; Bokoch G M
Reconstitution of recombinant N-formyl chemotactic peptide receptor with G protein.
Journal of leukocyte biology 1993;53(4):470-4.
1993: Heyworth P G; Knaus U G; Xu X; Uhlinger D J; Conroy L; Bokoch G M; Curnutte J T
Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase.
Molecular biology of the cell 1993;4(3):261-9.
1993: Bokoch G M
Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteins.
The Biochemical journal 1993;289 ( Pt 1)():17-24.
1993: Chuang T H; Xu X; Knaus U G; Hart M J; Bokoch G M
GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein.
The Journal of biological chemistry 1993;268(2):775-8.
1992: Schwaninger R; Plutner H; Bokoch G M; Balch W E
Multiple GTP-binding proteins regulate vesicular transport from the ER to Golgi membranes.
The Journal of cell biology 1992;119(5):1077-96.
1992: Knaus U G; Heyworth P G; Kinsella B T; Curnutte J T; Bokoch G M
Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase.
The Journal of biological chemistry 1992;267(33):23575-82.
1992: Bommakanti R K; Bokoch G M; Tolley J O; Schreiber R E; Siemsen D W; Klotz K N; Jesaitis A J
Reconstitution of a physical complex between the N-formyl chemotactic peptide receptor and G protein. Inhibition by pertussis toxin-catalyzed ADP ribosylation.
The Journal of biological chemistry 1992;267(11):7576-81.
1992: Bokoch G M; Prossnitz V
Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells.
The Journal of clinical investigation 1992;89(2):402-8.
1991: Bokoch G M; Quilliam L A; Bohl B P; Jesaitis A J; Quinn M T
Inhibition of Rap1A binding to cytochrome b558 of NADPH oxidase by phosphorylation of Rap1A.
Science (New York, N.Y.) 1991;254(5039):1794-6.
1991: Knaus U G; Heyworth P G; Evans T; Curnutte J T; Bokoch G M
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2.
Science (New York, N.Y.) 1991;254(5037):1512-5.
1991: Quilliam L A; Mueller H; Bohl B P; Prossnitz V; Sklar L A; Der C J; Bokoch G M
Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1628-35.
1991: Mueller H; Weingarten R; Ransnas L A; Bokoch G M; Sklar L A
Differential amplification of antagonistic receptor pathways in neutrophils.
The Journal of biological chemistry 1991;266(20):12939-43.
1990: Weingarten R; Bokoch G M
GTP binding proteins and signal transduction in the human neutrophil.
Immunology letters 1990;26(1):1-6.
1990: Goodman M G; Speizer L; Bokoch G; Kanter J; Brunton L L
Activity of an intracellular lymphocyte stimulator is independent of G-protein interactions, [Ca2+]i elevation, phosphoinositide hydrolysis, and protein kinase C translocation.
The Journal of biological chemistry 1990;265(21):12248-52.
1990: Weingarten R; Ransnäs L; Mueller H; Sklar L A; Bokoch G M
Mastoparan interacts with the carboxyl terminus of the alpha subunit of Gi.
The Journal of biological chemistry 1990;265(19):11044-9.
1990: Bokoch G M; Quilliam L A
Guanine nucleotide binding properties of rap1 purified from human neutrophils.
The Biochemical journal 1990;267(2):407-11.
1989: Jesaitis A J; Tolley J O; Bokoch G M; Allen R A
Regulation of chemoattractant receptor interaction with transducing proteins by organizational control in the plasma membrane of human neutrophils.
The Journal of cell biology 1989;109(6 Pt 1):2783-90.
1989: Cupo J F; Allen R A; Jesaitis A J; Bokoch G M
Reconstitution and characterization of the human neutrophil N-formyl peptide receptor and GTP binding proteins in phospholipid vesicles.
Biochimica et biophysica acta 1989;982(1):31-40.
1989: Quilliam L A; Lacal J C; Bokoch G M
Identification of rho as a substrate for botulinum toxin C3-catalyzed ADP-ribosylation.
FEBS letters 1989;247(2):221-6.
1988: Bokoch G M; Parkos C A; Mumby S M
Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.
The Journal of biological chemistry 1988;263(32):16744-9.
1988: Jesaitis A J; Bokoch G M; Tolley J O; Allen R A
Lateral segregation of neutrophil chemotactic receptors into actin- and fodrin-rich plasma membrane microdomains depleted in guanyl nucleotide regulatory proteins.
The Journal of cell biology 1988;107(3):921-8.
1988: Bokoch G M; Bickford K; Bohl B P
Subcellular localization and quantitation of the major neutrophil pertussis toxin substrate, Gn.
The Journal of cell biology 1988;106(6):1927-36.
1988: Bokoch G M; Parkos C A
Identification of novel GTP-binding proteins in the human neutrophil.
FEBS letters 1988;227(1):66-70.

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