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Gary Bokoch

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Timothy Y Huang; Eliezer Masliah; Sarah Michael; James J Moresco; Ali Sarkeshik; Tao Xu; John R Yates; Gary M Bokoch; Céline DerMardirossian
A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation.
Ritu Pathak; Michael A White; Michael C Howell; Anthony N Anselmo; Gary M Bokoch; Violaine D Delorme-Walker; Céline DerMardirossian
The microtubule-associated Rho activating factor GEF-H1 interacts with exocyst complex to regulate vesicle traffic.
Violaine D Delorme-Walker; Céline DerMardirossian; Jeffrey R Peterson; Clare M Waterman; Jonathan Chernoff; Gaudenz Danuser; Gary M Bokoch
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.

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All Publications

2013: Timothy Y Huang; Eliezer Masliah; Sarah Michael; James J Moresco; Ali Sarkeshik; Tao Xu; John R Yates; Gary M Bokoch; Céline DerMardirossian
A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation.
Molecular biology of the cell 2013;24(3):194-209.
2012: Ritu Pathak; Michael A White; Michael C Howell; Anthony N Anselmo; Gary M Bokoch; Violaine D Delorme-Walker; Céline DerMardirossian
The microtubule-associated Rho activating factor GEF-H1 interacts with exocyst complex to regulate vesicle traffic.
Developmental cell 2012;23(2):397-411.
2011: Violaine D Delorme-Walker; Céline DerMardirossian; Jeffrey R Peterson; Clare M Waterman; Jonathan Chernoff; Gaudenz Danuser; Gary M Bokoch
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.
The Journal of cell biology 2011;193(7):1289-303.
2011: Davide Gianni; Céline DerMardirossian; Gary M Bokoch
Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.
European journal of cell biology 2011;90(2-3):164-71.
2010: Davide Gianni; Nicolas Taulet; Céline DerMardirossian; Gary M Bokoch
c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells.
Molecular biology of the cell 2010;21(23):4287-98.
2010: Davide Gianni; Nicolas Taulet; Hui Zhang; Celine DerMardirossian; Jeremy Kister; Luis Martinez; William R Roush; Steven J Brown; Gary M Bokoch; Hugh Rosen
A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells.
ACS chemical biology 2010;5(10):981-93.
2010: Laurie S Minamide; Sankar Maiti; Judith A Boyle; Richard C Davis; Judith A Coppinger; Yunhe Bao; Timothy Y Huang; John Yates; Gary M Bokoch; James R Bamburg
Isolation and characterization of cytoplasmic cofilin-actin rods.
The Journal of biological chemistry 2010;285(8):5450-60.
2009: Y-C Chang; S-C Tien; Hwei-Fang Tien; H Zhang; Gary M Bokoch; Zee-Fen Chang
p210(Bcr-Abl) desensitizes Cdc42 GTPase signaling for SDF-1alpha-directed migration in chronic myeloid leukemia cells.
Oncogene 2009;28(46):4105-15.
2009: Gary M Bokoch; Becky Diebold; Jun-Sub Kim; Davide Gianni
Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases.
Antioxidants & redox signaling 2009;11(10):2429-41.
2009: Perihan Nalbant; Yuan-Chen Chang; Jörg Birkenfeld; Zee-Fen Chang; Gary M Bokoch
Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.
Molecular biology of the cell 2009;20(18):4070-82.
2009: Hui Zhang; Chunxiang Sun; Glogauer Michael; Gary M Bokoch
Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2718-28.
2009: Jun-Sub Kim; Timothy Y Huang; Gary M Bokoch
Reactive oxygen species regulate a slingshot-cofilin activation pathway.
Molecular biology of the cell 2009;20(11):2650-60.
2009: Gary M Bokoch
NADPH oxidases in innate immunity.
Journal of innate immunity 2009;1(6):507-8.
2009: Jun-Sub Kim; Gary M Bokoch
Anthrax edema toxin inhibits Nox1-mediated formation of reactive oxygen species by colon epithelial cells.
Journal of innate immunity 2009;1(2):145-52.
2009: Davide Gianni; Begoña Diaz; Nicolas Taulet; Bruce Fowler; Sara A Courtneidge; Gary M Bokoch
Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity.
Science signaling 2009;2(88):ra54.
2008: Christoph Huber; Annica Mårtensson; Gary M Bokoch; David Nemazee; Amanda Gavin
FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles.
The Journal of biological chemistry 2008;283(49):34002-12.
2008: Timothy Y Huang; Laurie S Minamide; James R Bamburg; Gary M Bokoch
Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation.
Developmental cell 2008;15(5):691-703.
2008: Jill E Chrencik; Alexei Brooun; Hui Zhang; Irimpan I Mathews; Greg L Hura; Scott A Foster; J Jefferson P Perry; Markus B Streiff; Paul Ramage; Hans Widmer; Gary M Bokoch; John A Tainer; Gisbert Weckbecker; Peter Kuhn
Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.
Journal of molecular biology 2008;380(5):828-43.
2008: Davide Gianni; Benjamin P Bohl; Sara A Courtneidge; Gary M Bokoch
The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1.
Molecular biology of the cell 2008;19(7):2984-94.
2008: Adil A Khan; Xiao Ou Mao; Surita Banwait; Celine M DerMardirossian; Gary M Bokoch; Kunlin Jin; David A Greenberg
Regulation of hypoxic neuronal death signaling by neuroglobin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(6):1737-47.
2008: Anna A Birukova; Tatiana K Zagranichnaya; Elena Alekseeva; Gary M Bokoch; Konstantin G Birukov
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
Journal of cellular physiology 2008;215(3):715-24.
2008: Yu-Ya Kao; Davide Gianni; Benjamin P Bohl; Ross M Taylor; Gary M Bokoch
Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism.
The Journal of biological chemistry 2008;283(19):12736-46.
2008: Jörg Birkenfeld; Perihan Nalbant; Soon-Hee Yoon; Gary M Bokoch
Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?
Trends in cell biology 2008;18(5):210-9.
2008: Yuan-Chen Chang; Perihan Nalbant; Jörg Birkenfeld; Zee-Fen Chang; Gary M Bokoch
GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA.
Molecular biology of the cell 2008;19(5):2147-53.
2008: Gary M Bokoch
PAK'n it in: identification of a selective PAK inhibitor.
Chemistry & biology 2008;15(4):305-6.
2008: Yangmi Lim; Ssang-Taek Lim; Alok Tomar; Margaret Gardel; Joie Trifilo; Xiao Lei Chen; Sean Uryu; Rafaela Canete-Soler; Jinbin Zhai; Hong Lin; William W Schlaepfer; Perihan Nalbant; Gary M Bokoch; Dusko Ilic; Clare M Waterman-Storer; David D Schlaepfer
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.
The Journal of cell biology 2008;180(1):187-203.
2007: JUN-SUB KIM; Becky A Diebold; Bernard M Babior; Ulla G Knaus; Gary M Bokoch
Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding.
The Journal of biological chemistry 2007;282(48):34787-800.
2007: Violaine Delorme; matthias machacek; Céline DerMardirossian; Karen L Anderson; Torsten Wittmann; Dorit Hanein; Clare M Waterman-Storer; Gaudenz Danuser; Gary M Bokoch
Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks.
Developmental cell 2007;13(5):646-62.
2007: Maria Zoudilova; Puneet Kumar; Lan Ge; Ping Wang; Gary M Bokoch; Kathryn DeFea
Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2.
The Journal of biological chemistry 2007;282(28):20634-46.
2007: Jörg Birkenfeld; Perihan Nalbant; Benjamin P Bohl; Olivier Pertz; Klaus M Hahn; Gary M Bokoch
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.
Developmental cell 2007;12(5):699-712.
2007: Tieming Zhao; Perihan Nalbant; Mikio Hoshino; Xuemei Dong; Dianqing Wu; Gary M Bokoch
Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function.
Journal of leukocyte biology 2007;81(4):1127-36.
2007: Tieming Zhao; Gary M Bokoch
Transduction of proteins into intact neutrophils.
Methods in molecular biology (Clifton, N.J.) 2007;412():115-23.
2007: Ulla G Knaus; Alison Bamberg; Gary M Bokoch
Rac and Rap GTPase activation assays.
Methods in molecular biology (Clifton, N.J.) 2007;412():59-67.
2007: Mark T Quinn; Frank R DeLeo; Gary M Bokoch
Neutrophil methods and protocols. Preface.
Methods in molecular biology (Clifton, N.J.) 2007;412():vii-viii.
2006: Céline DerMardirossian; Gabriel Rocklin; Ji-Yeon Seo; Gary M Bokoch
Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling.
Molecular biology of the cell 2006;17(11):4760-8.
2006: Kersi N Pestonjamasp; Carol Forster; Chunxiang Sun; Elisabeth M Gardiner; Benjamin P Bohl; Orion D Weiner; Gary M Bokoch; Glogauer Michael
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis.
Blood 2006;108(8):2814-20.
2006: Richard Belvindrah; Perihan Nalbant; Sheng Ding; Chuanyue Wu; Gary M Bokoch; Ulrich Müller
Integrin-linked kinase regulates Bergmann glial differentiation during cerebellar development.
Molecular and cellular neurosciences 2006;33(2):109-25.
2006: Gary M Bokoch; Tieming Zhao
Regulation of the phagocyte NADPH oxidase by Rac GTPase.
Antioxidants & redox signaling 2006;8(9-10):1533-48.
2006: Matthew A Crawford; Caroline V Aylott; Raymond W Bourdeau; Gary M Bokoch
Bacillus anthracis toxins inhibit human neutrophil NADPH oxidase activity.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7557-65.
2006: Aimee M deCathelineau; Gary M Bokoch
Peptide inhibitors MAP the way towards fighting anthrax pathogenesis.
The Biochemical journal 2006;395(1):e1-3.
2006: Anna A Birukova; Djanybek Adyshev; Boris A Gorshkov; Gary M Bokoch; Konstantin G Birukov; Alexander Dmitriyevich Verin
GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction.
American journal of physiology. Lung cellular and molecular physiology 2006;290(3):L540-8.
2006: Timothy Y Huang; Céline DerMardirossian; Gary M Bokoch
Cofilin phosphatases and regulation of actin dynamics.
Current opinion in cell biology 2006;18(1):26-31.
2006: Mary Stofega; Céline DerMardirossian; Gary M Bokoch
Affinity-based assay of Rho guanosine triphosphatase activation.
Methods in molecular biology (Clifton, N.J.) 2006;332():269-79.
2006: Céline DerMardirossian; Gary M Bokoch
Phosphorylation of RhoGDI by p21-activated kinase 1.
Methods in enzymology 2006;406():80-90.
2005: Xuemei Dong; Zhicheng Mo; Gary M Bokoch; Caiying Guo; Zhong Li; Dianqing Wu
P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils.
Current biology : CB 2005;15(20):1874-9.
2005: Céline DerMardirossian; Gary M Bokoch
GDIs: central regulatory molecules in Rho GTPase activation.
Trends in cell biology 2005;15(7):356-63.
2005: Tieming Zhao; Gary M Bokoch
Critical role of proline-rich tyrosine kinase 2 in reversion of the adhesion-mediated suppression of reactive oxygen species generation by human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(12):8049-55.
2005: Zeng-qiang Yuan; Donghwa Kim; Satoshi Kaneko; Melissa Sussman; Gary M Bokoch; Gary Kruh; Santo V Nicosia; Joseph R Testa; Jin Q Cheng
ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival.
The Journal of biological chemistry 2005;280(22):21483-90.
2005: Ayako Makino; Glogauer Michael; Gary M Bokoch; Shu Chien; Geert W Schmid-Schönbein
Control of neutrophil pseudopods by fluid shear: role of Rho family GTPases.
American journal of physiology. Cell physiology 2005;288(4):C863-71.
2005: Gary M Bokoch
Regulation of innate immunity by Rho GTPases.
Trends in cell biology 2005;15(3):163-71.
2005: Becky A Diebold; Gary M Bokoch
Rho GTPases and the control of the oxidative burst in polymorphonuclear leukocytes.
Current topics in microbiology and immunology 2005;291():91-111.
2005: Antje Gohla; Jörg Birkenfeld; Gary M Bokoch
Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics.
Nature cell biology 2005;7(1):21-9.
2004: Konstantin G Birukov; Valery N Bochkov; Anna A Birukova; Kamon Kawkitinarong; Alexander Rios; Alexander Leitner; Alexander Dmitriyevich Verin; Gary M Bokoch; Norbert Leitinger; Joe G. N. Garcia
Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac.
Circulation research 2004;95(9):892-901.
2004: Céline DerMardirossian; Andreas Schnelzer; Gary M Bokoch
Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase.
Molecular cell 2004;15(1):117-27.
2004: Becky A Diebold; Bruce Fowler; Justine Lu; Mary C Dinauer; Gary M Bokoch
Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species.
The Journal of biological chemistry 2004;279(27):28136-42.
2004: Mary R Stofega; Luraynne C Sanders; Elisabeth M Gardiner; Gary M Bokoch
Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions.
Molecular biology of the cell 2004;15(6):2965-77.
2004: Frank T Zenke; Mira Krendel; Céline DerMardirossian; Charles C King; Benjamin P Bohl; Gary M Bokoch
p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.
The Journal of biological chemistry 2004;279(18):18392-400.
2004: Torsten Wittmann; Gary M Bokoch; Clare M Waterman-Storer
Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1.
The Journal of biological chemistry 2004;279(7):6196-203.
2004: Nicolas Schrantz; Jean da Silva Correia; Bruce Fowler; Qingyuan Ge; Zijie Sun; Gary M Bokoch
Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.
The Journal of biological chemistry 2004;279(3):1922-31.
2004: Wei Li; Jianhua Fan; Mei Chen; Shengxi Guan; David Sawcer; Gary M Bokoch; David T Woodley
Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB.
Molecular biology of the cell 2004;15(1):294-309.
2003: Tieming Zhao; Valerie Benard; Benjamin P Bohl; Gary M Bokoch
The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophils.
The Journal of clinical investigation 2003;112(11):1732-40.
2003: Guo-Lei Zhou; Ya Zhuo; Charles C King; Benjamin H Fryer; Gary M Bokoch; Jeffrey Field
Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration.
Molecular and cellular biology 2003;23(22):8058-69.
2003: Gary M Bokoch; Ulla G Knaus
NADPH oxidases: not just for leukocytes anymore!
Trends in biochemical sciences 2003;28(9):502-8.
2003: Quanwen Li; Chi S Ho; Vlad Marinescu; Humaa Bhatti; Gary M Bokoch; Stephen A Ernst; Ronald W Holz; Edward L Stuenkel
Facilitation of Ca(2+)-dependent exocytosis by Rac1-GTPase in bovine chromaffin cells.
The Journal of physiology 2003;550(Pt 2):431-45.
2003: Torsten Wittmann; Gary M Bokoch; Clare M Waterman-Storer
Regulation of leading edge microtubule and actin dynamics downstream of Rac1.
The Journal of cell biology 2003;161(5):845-51.
2003: Rajyalakshmi S Rudrabhatla; Sunil K Sukumaran; Gary M Bokoch; Nemani V Prasadarao
Modulation of myosin light-chain phosphorylation by p21-activated kinase 1 in Escherichia coli invasion of human brain microvascular endothelial cells.
Infection and immunity 2003;71(5):2787-97.
2003: Lorena A Puto; Kersi N Pestonjamasp; Charles C King; Gary M Bokoch
p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling.
The Journal of biological chemistry 2003;278(11):9388-93.
2003: Gary M Bokoch
Biology of the p21-activated kinases.
Annual review of biochemistry 2003;72():743-81.
2002: Elisabeth M Gardiner; Kersi N Pestonjamasp; Benjamin P Bohl; Chester Chamberlain; Klaus M Hahn; Gary M Bokoch
Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis.
Current biology : CB 2002;12(23):2029-34.
2002: Allison L Berrier; Robert Martinez; Gary M Bokoch; Susan E LaFlamme
The integrin beta tail is required and sufficient to regulate adhesion signaling to Rac1.
Journal of cell science 2002;115(Pt 22):4285-91.
2002: Eun-Young Shin; Kyung-Sun Shin; Chan-Soo Lee; Kyung-Nam Woo; Song-Hua Quan; Nak-Kyun Soung; Young Gyu Kim; Choong Ik Cha; Seung Ryul Kim; Dongeun Park; Gary M Bokoch; Eung-Gook Kim
Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth.
The Journal of biological chemistry 2002;277(46):44417-30.
2002: Gary M Bokoch; Becky A Diebold
Current molecular models for NADPH oxidase regulation by Rac GTPase.
Blood 2002;100(8):2692-6.
2002: Melissa P Allen; Mei Xu; Daniel A Linseman; John E Pawlowski; Gary M Bokoch; Kim A Heidenreich; Margaret E Wierman
Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway.
The Journal of biological chemistry 2002;277(41):38133-40.
2002: Antje Gohla; Gary M Bokoch
14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin.
Current biology : CB 2002;12(19):1704-10.
2002: Gary M Bokoch
Microbial killing: hold the bleach and pass the salt!
Nature immunology 2002;3(4):340-2.
2002: Mira Krendel; Frank T Zenke; Gary M Bokoch
Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton.
Nature cell biology 2002;4(4):294-301.
2002: Maria Diakonova; Gary M Bokoch; Joel A Swanson
Dynamics of cytoskeletal proteins during Fcgamma receptor-mediated phagocytosis in macrophages.
Molecular biology of the cell 2002;13(2):402-11.
2002: Valerie Benard; Gary M Bokoch
Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods.
Methods in enzymology 2002;345():349-59.
2001: Céline DerMardirossian; Gary M Bokoch
Regulation of cell function by Rho GTPases.
Drug news & perspectives 2001;14(7):389-95.
2001: J E Lee; Gary M Bokoch; Bruce T Liang
A novel cardioprotective role of RhoA: new signaling mechanism for adenosine.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):1886-94.
2001: Alexander P Golovanov; D Hawkins; Igor Barsukov; R Badii; Gary M Bokoch; Lu-Yun Lian; Gordon Roberts
Structural consequences of site-directed mutagenesis in flexible protein domains: NMR characterization of the L(55,56)S mutant of RhoGDI.
European journal of biochemistry / FEBS 2001;268(8):2253-60.
2001: Becky A Diebold; Gary M Bokoch
Molecular basis for Rac2 regulation of phagocyte NADPH oxidase.
Nature immunology 2001;2(3):211-5.
2001: Alexander P Golovanov; Tsung-Hsien Chuang; Céline DerMardirossian; Igor Barsukov; D Hawkins; R Badii; Gary M Bokoch; Lu-Yun Lian; Gordon Roberts
Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI.
Journal of molecular biology 2001;305(1):121-35.
2000: Charles C King; Elisabeth M Gardiner; Frank T Zenke; Benjamin P Bohl; Alexandra C Newton; B A Hemmings; Gary M Bokoch
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).
The Journal of biological chemistry 2000;275(52):41201-9.
2000: Vadim Kraynov; Chester Chamberlain; Gary M Bokoch; Martin A Schwartz; S Slabaugh; Klaus M Hahn
Localized Rac activation dynamics visualized in living cells.
Science (New York, N.Y.) 2000;290(5490):333-7.
2000: S Dharmawardhane; Annette Schürmann; Mary Ann Sells; Jonathan Chernoff; Sandra L Schmid; Gary M Bokoch
Regulation of macropinocytosis by p21-activated kinase-1.
Molecular biology of the cell 2000;11(10):3341-52.
2000: Charles C King; Frank T Zenke; Philip E Dawson; EM Dutil; Alexandra C Newton; B A Hemmings; Gary M Bokoch
Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.
The Journal of biological chemistry 2000;275(24):18108-13.
2000: M Cecilia Subauste; Matthias von Herrath; Valerie Benard; Chester Chamberlain; Tsung-Hsien Chuang; K Chu; Gary M Bokoch; Klaus M Hahn
Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas.
The Journal of biological chemistry 2000;275(13):9725-33.
2000: Lu-Yun Lian; Igor Barsukov; Alexander P Golovanov; D I Hawkins; R Badii; Kong Hung SZE; Nicholas H Keep; Gary M Bokoch; Gordon Roberts
Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1.
Structure (London, England : 1993) 2000;8(1):47-55.
2000: Charles C King; Luraynne C Sanders; Gary M Bokoch
In vivo activity of wild-type and mutant PAKs.
Methods in enzymology 2000;325():315-27.
2000: Gary M Bokoch
Regulation of cell function by Rho family GTPases.
Immunologic research 2000;21(2-3):139-48.
2000: Annette Schürmann; A F Mooney; Luraynne C Sanders; Mary Ann Sells; Hong-Gang Wang; J C Reed; Gary M Bokoch
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.
Molecular and cellular biology 2000;20(2):453-61.
1999: William B Kiosses; RH Daniels; Carol A Otey; Gary M Bokoch; Martin A Schwartz
A role for p21-activated kinase in endothelial cell migration.
The Journal of cell biology 1999;147(4):831-44.
1999: Frank T Zenke; Charles C King; Benjamin P Bohl; Gary M Bokoch
Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity.
The Journal of biological chemistry 1999;274(46):32565-73.
1999: D C Edwards; Luraynne C Sanders; Gary M Bokoch; G N Gill
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics.
Nature cell biology 1999;1(5):253-9.
1999: S Dharmawardhane; D Brownson; M Lennartz; Gary M Bokoch
Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils.
Journal of leukocyte biology 1999;66(3):521-7.
1999: RH Daniels; Gary M Bokoch
p21-activated protein kinase: a crucial component of morphological signaling?
Trends in biochemical sciences 1999;24(9):350-5.
1999: Valerie Benard; Gary M Bokoch; Becky A Diebold
Potential drug targets: small GTPases that regulate leukocyte function.
Trends in pharmacological sciences 1999;20(9):365-70.
1999: Valerie Benard; Benjamin P Bohl; Gary M Bokoch
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases.
The Journal of biological chemistry 1999;274(19):13198-204.
1999: Luraynne C Sanders; F Matsumura; Gary M Bokoch; Primal De Lanerolle
Inhibition of myosin light chain kinase by p21-activated kinase.
Science (New York, N.Y.) 1999;283(5410):2083-5.
1999: RH Daniels; Frank T Zenke; Gary M Bokoch
alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms.
The Journal of biological chemistry 1999;274(10):6047-50.
1998: Erguang Li; Stupack Dwayne; Gary M Bokoch; Glen R Nemerow
Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases.
Journal of virology 1998;72(11):8806-12.
1998: Ulla G Knaus; Gary M Bokoch
The p21Rac/Cdc42-activated kinases (PAKs).
The international journal of biochemistry & cell biology 1998;30(8):857-62.
1998: K Zhou; Y Wang; J L Gorski; N Nomura; J Collard; Gary M Bokoch
Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42.
The Journal of biological chemistry 1998;273(27):16782-6.
1998: LS Price; Jay Leng; Martin A Schwartz; Gary M Bokoch
Activation of Rac and Cdc42 by integrins mediates cell spreading.
Molecular biology of the cell 1998;9(7):1863-71.
1998: Gary M Bokoch; AM Reilly; RH Daniels; Charles C King; A Olivera; S Spiegel; Ulla G Knaus
A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.
The Journal of biological chemistry 1998;273(14):8137-44.
1998: Zhixing K Pan; Richard D Ye; Sandra C Christiansen; MA Jagels; Gary M Bokoch; Bruce L Zuraw
Role of the Rho GTPase in bradykinin-stimulated nuclear factor-kappaB activation and IL-1beta gene expression in cultured human epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(6):3038-45.
1998: RH Daniels; P S Hall; Gary M Bokoch
Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells.
The EMBO journal 1998;17(3):754-64.
1998: T Rudel; Frank T Zenke; Tsung-Hsien Chuang; Gary M Bokoch
p21-activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(1):7-11.
1997: S Dharmawardhane; Luraynne C Sanders; Stuart S Martin; RH Daniels; Gary M Bokoch
Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells.
The Journal of cell biology 1997;138(6):1265-78.
1997: Tsung-Hsien Chuang; Klaus M Hahn; J D Lee; dennis danley; Gary M Bokoch
The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes.
Molecular biology of the cell 1997;8(9):1687-98.
1997: Sally H Zigmond; M Joyce; Jane Borleis; Gary M Bokoch; Peter N Devreotes
Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42.
The Journal of cell biology 1997;138(2):363-74.
1997: T Rudel; Gary M Bokoch
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2.
Science (New York, N.Y.) 1997;276(5318):1571-4.
1997: Mary Ann Sells; U G Knaus; S Bagrodia; DM Ambrose; Gary M Bokoch; Jonathan Chernoff
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.
Current biology : CB 1997;7(3):202-10.
1997: X Xu; Y Wang; D C Barry; STEPHEN CHANOCK; Gary M Bokoch
Guanine nucleotide binding properties of Rac2 mutant proteins and analysis of the responsiveness to guanine nucleotide dissociation stimulator.
Biochemistry 1997;36(3):626-32.
1997: S Dharmawardhane; Gary M Bokoch
Rho GTPases and leukocyte cytoskeletal regulation.
Current opinion in hematology 1997;4(1):12-8.
1996: Gary M Bokoch; Y Wang; Benjamin P Bohl; Mary Ann Sells; Lawrence A Quilliam; Ulla G Knaus
Interaction of the Nck adapter protein with p21-activated kinase (PAK1).
The Journal of biological chemistry 1996;271(42):25746-9.
1996: A Ptasznik; E R Prossnitz; D Yoshikawa; A Smrcka; Alexis E Traynor-Kaplan; Gary M Bokoch
A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils.
The Journal of biological chemistry 1996;271(41):25204-7.
1996: J Ding; Ulla G Knaus; Jian P Lian; Gary M Bokoch; John A Badwey
The renaturable 69- and 63-kDa protein kinases that undergo rapid activation in chemoattractant-stimulated guinea pig neutrophils are p21-activated kinases.
The Journal of biological chemistry 1996;271(40):24869-73.
1996: Gary M Bokoch
Interplay between Ras-related and heterotrimeric GTP binding proteins: lifestyles of the BIG and little.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(11):1290-5.
1996: dennis danley; Tsung-Hsien Chuang; Gary M Bokoch
Defective Rho GTPase regulation by IL-1 beta-converting enzyme-mediated cleavage of D4 GDP dissociation inhibitor.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(2):500-3.
1996: Christophe Lamaze; Tsung-Hsien Chuang; L J Terlecky; Gary M Bokoch; Sandra L Schmid
Regulation of receptor-mediated endocytosis by Rho and Rac.
Nature 1996;382(6587):177-9.
1996: S Na; Tsung-Hsien Chuang; A Cunningham; T G Turi; J H Hanke; Gary M Bokoch; dennis danley
D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis.
The Journal of biological chemistry 1996;271(19):11209-13.
1996: Gary M Bokoch; chris vlahos; Y Wang; Ulla G Knaus; Alexis E Traynor-Kaplan
Rac GTPase interacts specifically with phosphatidylinositol 3-kinase.
The Biochemical journal 1996;315 ( Pt 3)():775-9.
1996: Xiang-dong D Ren; Gary M Bokoch; Alexis E Traynor-Kaplan; G H Jenkins; R A Anderson; Martin A Schwartz
Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.
Molecular biology of the cell 1996;7(3):435-42.
1995: Tsung-Hsien Chuang; X Xu; Vesa Kaartinen; N Heisterkamp; J Groffen; Gary M Bokoch
Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10282-6.
1995: S Zhang; Jiahuai Han; Mary Ann Sells; Jonathan Chernoff; Ulla G Knaus; Richard J Ulevitch; Gary M Bokoch
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.
The Journal of biological chemistry 1995;270(41):23934-6.
1995: Gary M Bokoch
Chemoattractant signaling and leukocyte activation.
Blood 1995;86(5):1649-60.
1995: A Ptasznik; Alexis E Traynor-Kaplan; Gary M Bokoch
G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexes.
The Journal of biological chemistry 1995;270(34):19969-73.
1995: Ulla G Knaus; S Morris; H J Dong; Jonathan Chernoff; Gary M Bokoch
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors.
Science (New York, N.Y.) 1995;269(5221):221-3.
1995: O Dorseuil; M T Quinn; Gary M Bokoch
Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors.
Journal of leukocyte biology 1995;58(1):108-13.
1995: E R Prossnitz; R E Schreiber; Gary M Bokoch; Richard D Ye
Binding of low affinity N-formyl peptide receptors to G protein. Characterization of a novel inactive receptor intermediate.
The Journal of biological chemistry 1995;270(18):10686-94.
1995: Mark T Quinn; Gary M Bokoch
Measurement of Rac translocation from cytosol to membranes in activated neutrophils.
Methods in enzymology 1995;256():256-67.
1995: Ulla G Knaus; Gary M Bokoch
Purification of Rac2 from human neutrophils.
Methods in enzymology 1995;256():25-32.
1994: Gary M Bokoch; Benjamin P Bohl; Tsung-Hsien Chuang
Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.
The Journal of biological chemistry 1994;269(50):31674-9.
1994: Paul G Heyworth; Benjamin P Bohl; Gary M Bokoch; John T Curnutte
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.
The Journal of biological chemistry 1994;269(49):30749-52.
1994: L D Chong; Alexis E Traynor-Kaplan; Gary M Bokoch; Martin A Schwartz
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells.
Cell 1994;79(3):507-13.
1994: Tsung-Hsien Chuang; X Xu; Lawrence A Quilliam; Gary M Bokoch
SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism.
The Biochemical journal 1994;303 ( Pt 3)():761-7.
1994: X Xu; D C Barry; J Settleman; Martin A Schwartz; Gary M Bokoch
Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac.
The Journal of biological chemistry 1994;269(38):23569-74.
1994: F E Maly; Lawrence A Quilliam; O Dorseuil; Channing J Der; Gary M Bokoch
Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes.
The Journal of biological chemistry 1994;269(29):18743-6.
1994: Gary M Bokoch
Regulation of the human neutrophil NADPH oxidase by the Rac GTP-binding proteins.
Current opinion in cell biology 1994;6(2):212-8.
1994: Gary M Bokoch; Ulla G Knaus
The role of small GTP-binding proteins in leukocyte function.
Current opinion in immunology 1994;6(1):98-105.
1994: R E Schreiber; E R Prossnitz; Richard D Ye; Charles G Cochrane; Gary M Bokoch
Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides.
The Journal of biological chemistry 1994;269(1):326-31.
1994: Gary M Bokoch; Ulla G Knaus
Ras-related GTP-binding proteins and leukocyte signal transduction.
Current opinion in hematology 1994;1(1):53-60.
1993: Tsung-Hsien Chuang; Benjamin P Bohl; Gary M Bokoch
Biologically active lipids are regulators of Rac.GDI complexation.
The Journal of biological chemistry 1993;268(35):26206-11.
1993: Paul G Heyworth; Ulla G Knaus; J Settleman; John T Curnutte; Gary M Bokoch
Regulation of NADPH oxidase activity by Rac GTPase activating protein(s).
Molecular biology of the cell 1993;4(11):1217-23.
1993: Gary M Bokoch
Regulation of phagocyte function by low molecular weight GTP-binding proteins.
European journal of haematology 1993;51(5):313-7.
1993: Mark T Quinn; T Evans; L R Loetterle; Algirdas J Jesaitis; Gary M Bokoch
Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.
The Journal of biological chemistry 1993;268(28):20983-7.
1993: Gary M Bokoch; Channing J Der
Emerging concepts in the Ras superfamily of GTP-binding proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(9):750-9.
1993: R E Schreiber; E R Prossnitz; Richard D Ye; Charles G Cochrane; Algirdas J Jesaitis; Gary M Bokoch
Reconstitution of recombinant N-formyl chemotactic peptide receptor with G protein.
Journal of leukocyte biology 1993;53(4):470-4.
1993: Paul G Heyworth; Ulla G Knaus; X Xu; D J Uhlinger; L Conroy; Gary M Bokoch; John T Curnutte
Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase.
Molecular biology of the cell 1993;4(3):261-9.
1993: Tsung-Hsien Chuang; X Xu; Ulla G Knaus; Matthew J Hart; Gary M Bokoch
GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein.
The Journal of biological chemistry 1993;268(2):775-8.
1993: Gary M Bokoch
Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteins.
The Biochemical journal 1993;289 ( Pt 1)():17-24.
1992: R Schwaninger; Helen Plutner; Gary M Bokoch; William E Balch
Multiple GTP-binding proteins regulate vesicular transport from the ER to Golgi membranes.
The Journal of cell biology 1992;119(5):1077-96.
1992: Ulla G Knaus; Paul G Heyworth; B T Kinsella; John T Curnutte; Gary M Bokoch
Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase.
The Journal of biological chemistry 1992;267(33):23575-82.
1992: R K Bommakanti; Gary M Bokoch; J O Tolley; R E Schreiber; Daniel W Siemsen; Karl-Norbert Klotz; Algirdas J Jesaitis
Reconstitution of a physical complex between the N-formyl chemotactic peptide receptor and G protein. Inhibition by pertussis toxin-catalyzed ADP ribosylation.
The Journal of biological chemistry 1992;267(11):7576-81.
1992: Gary M Bokoch; V Prossnitz
Isoprenoid metabolism is required for stimulation of the respiratory burst oxidase of HL-60 cells.
The Journal of clinical investigation 1992;89(2):402-8.
1991: Gary M Bokoch; Lawrence A Quilliam; Benjamin P Bohl; Algirdas J Jesaitis; M T Quinn
Inhibition of Rap1A binding to cytochrome b558 of NADPH oxidase by phosphorylation of Rap1A.
Science (New York, N.Y.) 1991;254(5039):1794-6.
1991: Ulla G Knaus; Paul G Heyworth; T Evans; John T Curnutte; Gary M Bokoch
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2.
Science (New York, N.Y.) 1991;254(5037):1512-5.
1991: Lawrence A Quilliam; H Mueller; Benjamin P Bohl; V Prossnitz; L A Sklar; Channing J Der; Gary M Bokoch
Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1628-35.
1991: H Mueller; R Weingarten; L A Ransnas; Gary M Bokoch; L A Sklar
Differential amplification of antagonistic receptor pathways in neutrophils.
The Journal of biological chemistry 1991;266(20):12939-43.
1990: R Weingarten; Gary M Bokoch
GTP binding proteins and signal transduction in the human neutrophil.
Immunology letters 1990;26(1):1-6.
1990: M G Goodman; L Speizer; Gary M Bokoch; Joan R Kanter; L L Brunton
Activity of an intracellular lymphocyte stimulator is independent of G-protein interactions, [Ca2+]i elevation, phosphoinositide hydrolysis, and protein kinase C translocation.
The Journal of biological chemistry 1990;265(21):12248-52.
1990: R Weingarten; L Ransnäs; H Mueller; L A Sklar; Gary M Bokoch
Mastoparan interacts with the carboxyl terminus of the alpha subunit of Gi.
The Journal of biological chemistry 1990;265(19):11044-9.
1990: Gary M Bokoch; Lawrence A Quilliam
Guanine nucleotide binding properties of rap1 purified from human neutrophils.
The Biochemical journal 1990;267(2):407-11.
1989: Algirdas J Jesaitis; J O Tolley; Gary M Bokoch; R A Allen
Regulation of chemoattractant receptor interaction with transducing proteins by organizational control in the plasma membrane of human neutrophils.
The Journal of cell biology 1989;109(6 Pt 1):2783-90.
1989: J F Cupo; R A Allen; Algirdas J Jesaitis; Gary M Bokoch
Reconstitution and characterization of the human neutrophil N-formyl peptide receptor and GTP binding proteins in phospholipid vesicles.
Biochimica et biophysica acta 1989;982(1):31-40.
1989: Lawrence A Quilliam; J C Lacal; Gary M Bokoch
Identification of rho as a substrate for botulinum toxin C3-catalyzed ADP-ribosylation.
FEBS letters 1989;247(2):221-6.
1988: Gary M Bokoch; Charles A Parkos; S M Mumby
Purification and characterization of the 22,000-dalton GTP-binding protein substrate for ADP-ribosylation by botulinum toxin, G22K.
The Journal of biological chemistry 1988;263(32):16744-9.
1988: Algirdas J Jesaitis; Gary M Bokoch; J O Tolley; R A Allen
Lateral segregation of neutrophil chemotactic receptors into actin- and fodrin-rich plasma membrane microdomains depleted in guanyl nucleotide regulatory proteins.
The Journal of cell biology 1988;107(3):921-8.
1988: Gary M Bokoch; K Bickford; B P Bohl
Subcellular localization and quantitation of the major neutrophil pertussis toxin substrate, Gn.
The Journal of cell biology 1988;106(6):1927-36.
1988: Gary M Bokoch; Charles A Parkos
Identification of novel GTP-binding proteins in the human neutrophil.
FEBS letters 1988;227(1):66-70.