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Viktor Steimle

Research Profile

Genes & Molecular Sequences

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Viktor Steimle; Luc A Otten; Madeleine Zufferey; Bernard Mach
Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). 1993.
Luc A Otten; Salomé LeibundGut-Landmann; Joachim Huarte; Isabelle C Kos-Braun; Christine Lavanchy; Emmanuèle Barras; Bettina Borisch; Viktor Steimle; Hans Acha-Orbea; Walter Reith
Revisiting the specificity of the MHC class II transactivator CIITA in vivo.
Margarita M Camacho Carvajal; Bernd Wollscheid; Ruedi Aebersold; Viktor Steimle; Wolfgang W A Schamel
Two-dimensional Blue native/SDS gel electrophoresis of multi-protein complexes from whole cellular lysates: a proteomics approach.

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All Publications

2007: Viktor Steimle; Luc A Otten; Madeleine Zufferey; Bernard Mach
Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). 1993.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):6677-88.
2006: Luc A Otten; Salomé LeibundGut-Landmann; Joachim Huarte; Isabelle C Kos-Braun; Christine Lavanchy; Emmanuèle Barras; Bettina Borisch; Viktor Steimle; Hans Acha-Orbea; Walter Reith
Revisiting the specificity of the MHC class II transactivator CIITA in vivo.
European journal of immunology 2006;36(6):1548-58.
2004: Margarita M Camacho Carvajal; Bernd Wollscheid; Ruedi Aebersold; Viktor Steimle; Wolfgang W A Schamel
Two-dimensional Blue native/SDS gel electrophoresis of multi-protein complexes from whole cellular lysates: a proteomics approach.
Molecular & cellular proteomics : MCP 2004;3(2):176-82.
2004: Margarita M Camacho Carvajal; Sebastian Klingler; Felix Schnappauf; Sandra B Hake; Viktor Steimle
Importance of class II transactivator leucine-rich repeats for dominant-negative function and nucleo-cytoplasmic transport.
International immunology 2004;16(1):65-75.
2003: Sandra B Hake; Helen M Tobin; Viktor Steimle; Lisa K Denzin
Comparison of the transcriptional regulation of classical and non-classical MHC class II genes.
European journal of immunology 2003;33(9):2361-71.
2003: Felix Schnappauf; Sandra B Hake; Margarita M Camacho Carvajal; Séverine Bontron; Barbara Lisowska-Grospierre; Viktor Steimle
N-terminal destruction signals lead to rapid degradation of the major histocompatibility complex class II transactivator CIITA.
European journal of immunology 2003;33(8):2337-47.
2003: Luc A Otten; Fabienne Tacchini-Cottier; Michael Lohoff; Francesco Annunziato; Lorenzo Cosmi; Léonardo Scarpellino; Jacques Louis; Viktor Steimle; Walter Reith; Hans Acha-Orbea
Deregulated MHC class II transactivator expression leads to a strong Th2 bias in CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1150-7.
2002: Magda Dziembowska; Marie-Claude Fondaneche; jocelyn vedrenne; Giovanna Barbieri; Wojciech Wiszniewski; Capucine Picard; Andrew J Cant; Viktor Steimle; Dominique Charron; Catherine Alca-Loridan; Alain Fischer; Barbara Lisowska-Grospierre
Three novel mutations of the CIITA gene in MHC class II-deficient patients with a severe immunodeficiency.
Immunogenetics 2002;53(10-11):821-9.
2001: Wojciech Wiszniewski; Marie-Claude Fondaneche; Françoise Le Deist; M Kanariou; Françoise Selz; Nicole Brousse; Viktor Steimle; Giovanna Barbieri; Catherine Alcaide-Loridan; Dominique Charron; Alain Fischer; Barbara Lisowska-Grospierre
Mutation in the class II trans-activator leading to a mild immunodeficiency.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1787-94.
2000: Sandra B Hake; krzysztof masternak; C Kammerbauer; Christian J Janzen; Walter Reith; Viktor Steimle
CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.
Molecular and cellular biology 2000;20(20):7716-25.
2000: krzysztof masternak; Annick Muhlethaler-Mottet; Jean Villard; Madeleine Zufferey; Viktor Steimle; Walter Reith
CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex.
Genes & development 2000;14(9):1156-66.
1998: Luc A Otten; Viktor Steimle; Séverine Bontron; Bernard Mach
Quantitative control of MHC class II expression by the transactivator CIITA.
European journal of immunology 1998;28(2):473-8.
1997: Séverine Bontron; Catherine Ucla; Bernard Mach; Viktor Steimle
Efficient repression of endogenous major histocompatibility complex class II expression through dominant negative CIITA mutants isolated by a functional selection strategy.
Molecular and cellular biology 1997;17(8):4249-58.
1997: M B Bradley; J M Fernandez; G Ungers; T Diaz-Barrientos; Viktor Steimle; Bernard Mach; Richard J O'Reilly; J S Lee
Correction of defective expression in MHC class II deficiency (bare lymphocyte syndrome) cells by retroviral transduction of CIITA.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1086-95.
1997: Annick Muhlethaler-Mottet; Luc A Otten; Viktor Steimle; Bernard Mach
Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.
The EMBO journal 1997;16(10):2851-60.
1997: Séverine Bontron; Viktor Steimle; Catherine Ucla; M M Eibl; Bernard Mach
Two novel mutations in the MHC class II transactivator CIITA in a second patient from MHC class II deficiency complementation group A.
Human genetics 1997;99(4):541-6.
1996: Viktor Steimle; Walter Reith; Bernard Mach
Major histocompatibility complex class II deficiency: a disease of gene regulation.
Advances in immunology 1996;61():327-40.
1996: Bernard Mach; Viktor Steimle; E Martinez-Soria; Walter Reith
Regulation of MHC class II genes: lessons from a disease.
Annual review of immunology 1996;14():301-31.
1995: Walter Reith; Viktor Steimle; Bernard Mach
Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes.
Immunology today 1995;16(11):539-46.
1995: Viktor Steimle; Bernard Mach
Complementation cloning of mammalian transcriptional regulators: the example of MHC class II gene regulators.
Current opinion in genetics & development 1995;5(5):646-51.
1995: I Kern; Viktor Steimle; Claire-Anne Siegrist; Bernard Mach
The two novel MHC class II transactivators RFX5 and CIITA both control expression of HLA-DM genes.
International immunology 1995;7(8):1295-9.
1995: Walter Reith; Viktor Steimle; B Durand; M Kobr; Bernard Mach
Regulation of MHC class II gene expression.
Immunobiology 1995;193(2-4):248-53.
1995: Viktor Steimle; B Durand; Emmanuèle Barras; Madeleine Zufferey; M R Hadam; Bernard Mach; Walter Reith
A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).
Genes & development 1995;9(9):1021-32.
1994: P Silacci; A Mottet; Viktor Steimle; Walter Reith; Bernard Mach
Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA.
The Journal of experimental medicine 1994;180(4):1329-36.
1994: E Martínez-Soria; Viktor Steimle; C Burkhardt; P Beffy; Jean-Marie Tiercy; J T Epplen; Bernard Mach; C Irlé
An HLA-DRB alpha-helix motif shared by DR11 and DR8 alleles is implicated in the pluriallelic restriction of peptide-specific T-cell lines.
Human immunology 1994;40(4):279-90.
1994: Viktor Steimle; Claire-Anne Siegrist; A Mottet; Barbara Lisowska-Grospierre; Bernard Mach
Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.
Science (New York, N.Y.) 1994;265(5168):106-9.
1994: Bernard Mach; Viktor Steimle; Walter Reith
MHC class II-deficient combined immunodeficiency: a disease of gene regulation.
Immunological reviews 1994;138():207-21.
1993: Viktor Steimle; Luc A Otten; Madeleine Zufferey; Bernard Mach
Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome).
Cell 1993;75(1):135-46.
1989: A Urlacher; Jean-Marie Tiercy; Michael Schlesier; Viktor Steimle; H Peter; M Jeannet; Bernard Mach; MM Tongio
A T-cell clone recognizing an MLC stimulating epitope located on the DRw11 beta 1 chain.
Human immunology 1989;26(4):321-32.
1989: A E Hinkkanen; Viktor Steimle; Michael Schlesier; H H Peter; J T Epplen
The antigen receptor of an autoreactive T-cell clone from human rheumatic synovia.
Immunogenetics 1989;29(2):131-3.
1988: Viktor Steimle; A Hinkkanen; Michael Schlesier; J T Epplen
A novel HLA-DR beta I sequence from the DRw11 haplotype.
Immunogenetics 1988;28(3):208-10.
1987: J T Epplen; JOHANNA CHLUBA; C Hardt; A Hinkkanen; Viktor Steimle; H Stockinger
Mammalian T-lymphocyte antigen receptor genes: genetic and nongenetic potential to generate variability.
Human genetics 1987;75(4):300-10.