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David Stein

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Benjamin W Neuman; David A Stein; Joey P C Ting; Lydia H Bederka; Hong M Moulton; Michael J Buchmeier
Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors.
Eva Böttcher-Friebertshäuser; David A Stein; Hans-Dieter Klenk; Wolfgang Garten
Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2.
Huifang M Zhang; Xin Ye; Yue Su; Ji Yuan; Zhen Liu; David A Stein; Decheng Yang
Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1.

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All Publications

2011: Benjamin W Neuman; David A Stein; Joey P C Ting; Lydia H Bederka; Hong M Moulton; Michael J Buchmeier
Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors.
Antimicrobial agents and chemotherapy 2011;55(10):4631-8.
2011: Eva Böttcher-Friebertshäuser; David A Stein; Hans-Dieter Klenk; Wolfgang Garten
Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2.
Journal of virology 2011;85(4):1554-62.
2010: Huifang M Zhang; Xin Ye; Yue Su; Ji Yuan; Zhen Liu; David A Stein; Decheng Yang
Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1.
Journal of virology 2010;84(17):8446-59.
2009: Megan Moerdyk-Schauwecker; David A Stein; Kathleen Eide; Robert E Blouch; Robert J Bildfell; Patrick Iversen; Ling Jin
Inhibition of HSV-1 ocular infection with morpholino oligomers targeting ICP0 and ICP27.
Antiviral research 2009;84(2):131-41.
2009: Verena Krähling; David A Stein; Martin Spiegel; Friedemann Weber; Elke Mühlberger
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity.
Journal of virology 2009;83(5):2298-309.
2008: Bo Zhang; Hongping Dong; David A Stein; Pei-Yong Shi
Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance RNA/RNA base pairings.
Virology 2008;382(1):98-106.
2008: David A Stein; Claire Y-H Huang; Shawn Silengo; Adams Amantana; Stacy Crumley; Robert E Blouch; Patrick L Iversen; Richard M Kinney
Treatment of AG129 mice with antisense morpholino oligomers increases survival time following challenge with dengue 2 virus.
The Journal of antimicrobial chemotherapy 2008;62(3):555-65.
2008: Gülsah Gabriel; Alexandra Nordmann; David A Stein; Patrick L Iversen; Hans-Dieter Klenk
Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus.
The Journal of general virology 2008;89(Pt 4):939-48.
2008: Bo Zhang; Hongping Dong; David A Stein; Patrick L Iversen; Pei-Yong Shi
West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions.
Virology 2008;373(1):1-13.
2008: Bernard Lebleu; Hong M Moulton; Rachida Abes; Gabriela Ivanova; Saïd Abes; David A Stein; Patrick L Iversen; Andrey A Arzumanov; Michael J Gait
Cell penetrating peptide conjugates of steric block oligonucleotides.
Advanced drug delivery reviews 2008;60(4-5):517-29.
2008: David A Stein
Inhibition of RNA virus infections with peptide-conjugated morpholino oligomers.
Current pharmaceutical design 2008;14(25):2619-34.
2008: Christopher Lupfer; David A Stein; Dan V Mourich; Samuel E Tepper; Patrick L Iversen; Manoj Pastey
Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers.
Archives of virology 2008;153(5):929-37.
2008: David A Stein; Pei-Yong Shi
Nucleic acid-based inhibition of flavivirus infections.
Frontiers in bioscience : a journal and virtual library 2008;13():1385-95.
2007: Hong M Moulton; Susan Fletcher; Benjamin W Neuman; Graham McClorey; David A Stein; Saïd Abes; Stephen D Wilton; M J Buchmeier; Bernard Lebleu; Patrick L Iversen
Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo.
Biochemical Society transactions 2007;35(Pt 4):826-8.
2007: Tia S Deas; Corey J Bennett; Susan A Jones; Mark Tilgner; Ping Ren; Melissa J Behr; David A Stein; Patrick L Iversen; Laura D Kramer; Kristen A Bernard; Pei-Yong Shi
In vitro resistance selection and in vivo efficacy of morpholino oligomers against West Nile virus.
Antimicrobial agents and chemotherapy 2007;51(7):2470-82.
2007: Renaud BURRER; Benjamin W Neuman; Joey P C Ting; David A Stein; Hong M Moulton; Patrick L Iversen; Peter Kuhn; Michael J Buchmeier
Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models.
Journal of virology 2007;81(11):5637-48.
2007: Yanjin Zhang; Kai-Yu Wang; David A Stein; Deendayal Patel; Rheba Watkins; Hong M Moulton; Patrick L Iversen; David O Matson
Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers.
Antiviral research 2007;73(1):12-23.
2006: Ji Yuan; David A Stein; Travis Lim; Dexin Qiu; Shaun Coughlin; Zhen Liu; Yinjing Wang; Robert Blouch; Hong M Moulton; Patrick L Iversen; Decheng Yang
Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site.
Journal of virology 2006;80(23):11510-9.
2006: Qing Ge; Manoj Pastey; Darwyn Kobasa; Piliapan Puthavathana; Christopher Lupfer; Richard K Bestwick; Patrick L Iversen; Jianzhu Chen; David A Stein
Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers.
Antimicrobial agents and chemotherapy 2006;50(11):3724-33.
2006: Yanjin Zhang; David A Stein; Su-Min Fan; Kai-Yu Wang; Andrew D Kroeker; Xiang-Jin Meng; Patrick L Iversen; David O Matson
Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers.
Veterinary microbiology 2006;117(2-4):117-29.
2006: Alvin W Smith; Patrick L Iversen; Douglas E Skilling; David A Stein; Karin Bok; David O Matson
Vesivirus viremia and seroprevalence in humans.
Journal of medical virology 2006;78(5):693-701.
2006: Sven Enterlein; Kelly L Warfield; Dana L Swenson; David A Stein; Jeffery L Smith; C Scott Gamble; Andrew D Kroeker; Patrick L Iversen; Sina Bavari; Elke Mühlberger
VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice.
Antimicrobial agents and chemotherapy 2006;50(3):984-93.
2006: Benjamin W Neuman; David A Stein; Andrew D Kroeker; Hong M Moulton; Richard K Bestwick; Patrick L Iversen; Michael J Buchmeier
Inhibition and escape of SARS-CoV treated with antisense morpholino oligomers.
Advances in experimental medicine and biology 2006;581():567-71.
2006: Kelly L Warfield; Dana L Swenson; Gene Garrard Olinger; Donald K Nichols; William D Pratt; Robert Blouch; David A Stein; M Javad Aman; Patrick L Iversen; Sina Bavari
Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.
PLoS pathogens 2006;2(1):e1.
2005: Benjamin W Neuman; David A Stein; Andrew D Kroeker; Michael J Churchill; Alice M Kim; Peter Kuhn; Philip Dawson; Hong M Moulton; Richard K Bestwick; Patrick L Iversen; Michael J Buchmeier
Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers.
Journal of virology 2005;79(15):9665-76.
2005: Marta Alonso; David A Stein; E Thomann; Hong M Moulton; JC Leong; P Iversen; Dan V Mourich
Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptide-conjugated morpholino oligomers.
Journal of fish diseases 2005;28(7):399-410.
2005: Michelle H Nelson; David A Stein; Andrew D Kroeker; Susie A Hatlevig; Patrick L Iversen; Hong M Moulton
Arginine-rich peptide conjugation to morpholino oligomers: effects on antisense activity and specificity.
Bioconjugate chemistry 2005;16(4):959-66.
2005: Richard M Kinney; Claire Y-H Huang; Becky C Rose; Andrew D Kroeker; Theo W Dreher; Patrick L Iversen; David A Stein
Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers.
Journal of virology 2005;79(8):5116-28.
2005: Tia S Deas; Iwona Binduga-Gajewska; Mark Tilgner; Ping Ren; David A Stein; Hong M Moulton; Patrick L Iversen; Elizabeth B Kauffman; Laura D Kramer; Pei-Yong Shi
Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication.
Journal of virology 2005;79(8):4599-609.
2004: Benjamin W Neuman; David A Stein; Andrew D Kroeker; Amy D Paulino; Hong M Moulton; Patrick L Iversen; Michael J Buchmeier
Antisense morpholino-oligomers directed against the 5' end of the genome inhibit coronavirus proliferation and growth.
Journal of virology 2004;78(11):5891-9.
2003: Bruce L Geller; Jesse Deere; David A Stein; Andrew D Kroeker; Hong M Moulton; Patrick L Iversen
Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomers.
Antimicrobial agents and chemotherapy 2003;47(10):3233-9.
2002: Alvin W Smith; David O Matson; David A Stein; Douglas E Skilling; Andrew D Kroeker; Tamas Berke; Patrick L Iversen
Antisense treatment of caliciviridae: an emerging disease agent of animals and humans.
Current opinion in molecular therapeutics 2002;4(2):177-84.
2002: Alvin W Smith; Douglas E Skilling; David O Matson; Andrew D Kroeker; David A Stein; Tamas Berke; Patrick L Iversen
Detection of vesicular exanthema of swine-like calicivirus in tissues from a naturally infected spontaneously aborted bovine fetus.
Journal of the American Veterinary Medical Association 2002;220(4):455-8.
2001: David A Stein; Douglas E Skilling; Patrick L Iversen; Alvin W Smith
Inhibition of Vesivirus infections in mammalian tissue culture with antisense morpholino oligomers.
Antisense & nucleic acid drug development 2001;11(5):317-25.