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Roland Stein

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Chad S Hunter; Roland Stein
Characterization of an apparently novel β-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdx1 genes.
C Dai; Y Hang; Greg Poffenberger; Marcela Brissova; Zhongyi Chen; A Shostak; Roland Stein; C Thompson; Alvin C Powers
Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.
Yan Hang; Roland Stein
MafA and MafB activity in pancreatic β cells.

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All Publications

2013: Chad S Hunter; Roland Stein
Characterization of an apparently novel β-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdx1 genes.
The Journal of biological chemistry 2013;288(6):3795-803.
2012: C Dai; Y Hang; Greg Poffenberger; Marcela Brissova; Zhongyi Chen; A Shostak; Roland Stein; C Thompson; Alvin C Powers
Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets.
Diabetologia 2012;55(3):707-18.
2011: Yan Hang; Roland Stein
MafA and MafB activity in pancreatic β cells.
Trends in endocrinology and metabolism: TEM 2011;22(9):364-73.
2011: Lynley D Pound; Yan Hang; Suparna A Sarkar; Yingda Wang; Laurel A Milam; James K Oeser; Richard L Printz; Catherine E Lee; Roland Stein; John C Hutton; Richard M O'Brien
The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer.
The Biochemical journal 2011;433(1):95-105.
2010: Shuangli Guo; Nathan L Vanderford; Roland Stein
Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding.
The Journal of biological chemistry 2010;285(17):12655-61.
2009: Martin E Fernandez Zapico; Jennifer C Van Velkinburgh; Ruth Gutiérrez-Aguilar; Bernadette Neve; philippe froguel; Raul Urrutia; Roland Stein
MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells.
The Journal of biological chemistry 2009;284(52):36482-90.
2009: Shuangli Guo; Ryan Burnette; Li Zhao; Nathan L Vanderford; Vincent Poitout; derek hagman; Eva Henderson; Sabire Ozcan; Brian E Wadzinski; Roland Stein
The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation.
The Journal of biological chemistry 2009;284(2):759-65.
2008: Amanda M Vanhoose; Susan E Samaras; Isabella Artner; Eva Henderson; Yan Hang; Roland Stein
MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cells.
The Journal of biological chemistry 2008;283(33):22612-9.
2008: Isabella Artner; Yan Hang; Min Guo; Guoqiang Gu; Roland Stein
MafA is a dedicated activator of the insulin gene in vivo.
The Journal of endocrinology 2008;198(2):271-9.
2007: Taka-aki Matsuoka; Hideaki Kaneto; Roland Stein; Takeshi Miyatsuka; Dan Kawamori; Eva Henderson; Itaru Kojima; Munehide Matsuhisa; Masatsugu Hori; Yoshimitsu Yamasaki
MafA regulates expression of genes important to islet beta-cell function.
Molecular endocrinology (Baltimore, Md.) 2007;21(11):2764-74.
2007: Isabella Artner; Bruno Blanchi; Jeffrey C Raum; Min Guo; Tomomi Kaneko; Sabine Cordes; Michael H Sieweke; Roland Stein
MafB is required for islet beta cell maturation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):3853-8.
2006: Elizabeth Tweedie; Isabella Artner; Laura Crawford; Greg Poffenberger; Bernard Thorens; Roland Stein; Alvin C Powers; Maureen Gannon
Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells.
Diabetes 2006;55(12):3264-70.
2006: Jeffrey C Raum; Kevin Gerrish; Isabella Artner; Eva Henderson; Min Guo; Lori Sussel; Jonathan Schisler; Christopher B Newgard; Roland Stein
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.
Molecular and cellular biology 2006;26(15):5735-43.
2006: Kohjiro Ueki; Terumasa Okada; Jiang Hu; Chong Wee Liew; Anke Assmann; Gabriella M Dahlgren; Jennifer L Peters; Jonathan G Shackman; Min Zhang; Isabella Artner; Leslie S Satin; Roland Stein; Martin Holzenberger; Robert T Kennedy ; C Ronald Kahn; Rohit N Kulkarni
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.
Nature genetics 2006;38(5):583-8.
2006: Vincent Poitout; Derek Hagman; Roland Stein; Isabella Artner; R Paul Robertson; Jamie S Harmon
Regulation of the insulin gene by glucose and fatty acids.
The Journal of nutrition 2006;136(4):873-6.
2006: John Le Lay; Roland Stein
Involvement of PDX-1 in activation of human insulin gene transcription.
The Journal of endocrinology 2006;188(2):287-94.
2006: Isabella Artner; John Le Lay; Yan Hang; Lynda Elghazi-Cras; Jonathan Schisler; Eva Henderson; Beatriz Sosa-Pineda; Roland Stein
MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.
Diabetes 2006;55(2):297-304.
2005: Jennifer C Van Velkinburgh; Susan E Samaras; Kevin Gerrish; Isabella Artner; Roland Stein
Interactions between areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas.
The Journal of biological chemistry 2005;280(46):38438-44.
2005: Li Zhao; Min Guo; Taka-Aki Matsuoka; derek hagman; Susan D Parazzoli; Vincent Poitout; Roland Stein
The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription.
The Journal of biological chemistry 2005;280(12):11887-94.
2005: Jamie S Harmon; Roland Stein; R Paul Robertson
Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells.
The Journal of biological chemistry 2005;280(12):11107-13.
2004: John Le Lay; Taka-Aki Matsuoka; Eva Henderson; Roland Stein
Identification of a novel PDX-1 binding site in the human insulin gene enhancer.
The Journal of biological chemistry 2004;279(21):22228-35.
2004: Yi Qiu; Min Guo; Suming Huang; Roland Stein
Acetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression.
The Journal of biological chemistry 2004;279(11):9796-802.
2004: Taka-aki Matsuoka; Isabella Artner; Eva Henderson; Anthony R Means; Maike Sander; Roland Stein
The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2930-3.
2004: Kevin Gerrish; Jennifer C Van Velkinburgh; Roland Stein
Conserved transcriptional regulatory domains of the pdx-1 gene.
Molecular endocrinology (Baltimore, Md.) 2004;18(3):533-48.
2003: Taka-aki Matsuoka; Li Zhao; Isabella Artner; Harry Jarrett; David Friedman; Anthony R Means; Roland Stein
Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells.
Molecular and cellular biology 2003;23(17):6049-62.
2003: Cyrus C Martin; Christina A Svitek; James K Oeser; Eva Henderson; Roland Stein; Richard M O'Brien
Upstream stimulatory factor (USF) and neurogenic differentiation/beta-cell E box transactivator 2 (NeuroD/BETA2) contribute to islet-specific glucose-6-phosphatase catalytic-subunit-related protein (IGRP) gene expression.
The Biochemical journal 2003;371(Pt 3):675-86.
2003: Susan E Samaras; Li Zhao; Anthony R Means; Eva Henderson; Taka-Aki Matsuoka; Roland Stein
The islet beta cell-enriched RIPE3b1/Maf transcription factor regulates pdx-1 expression.
The Journal of biological chemistry 2003;278(14):12263-70.
2003: Michelle A Cissell; Li Zhao; Lori Sussel; Eva Henderson; Roland Stein
Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.
The Journal of biological chemistry 2003;278(2):751-6.
2002: Helle Vestergaard Petersen; Jan N Jensen; Roland Stein; Palle Serup
Glucose induced MAPK signalling influences NeuroD1-mediated activation and nuclear localization.
FEBS letters 2002;528(1-3):241-5.
2002: Susan E Samaras; Michelle A Cissell; Kevin Gerrish; Christopher V E Wright; Maureen Gannon; Roland Stein
Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6.
Molecular and cellular biology 2002;22(13):4702-13.
2002: Yi Qiu; Min Guo; Suming Huang; Roland Stein
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.
Molecular and cellular biology 2002;22(2):412-20.
2001: Kevin Gerrish; Michelle A Cissell; Roland Stein
The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene.
The Journal of biological chemistry 2001;276(51):47775-84.
2001: Taka-Aki Matsuoka; Li Zhao; Roland Stein
The DNA binding activity of the RIPE3b1 transcription factor of insulin appears to be influenced by tyrosine phosphorylation.
The Journal of biological chemistry 2001;276(25):22071-6.
2000: M Peshavaria; Michelle A Cissell; Eva Henderson; Helle Vestergaard Petersen; Roland Stein
The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells.
Molecular endocrinology (Baltimore, Md.) 2000;14(12):1907-17.
2000: Li Zhao; Michelle A Cissell; Eva Henderson; Roger J Colbran; Roland Stein
The RIPE3b1 activator of the insulin gene is composed of a protein(s) of approximately 43 kDa, whose DNA binding activity is inhibited by protein phosphatase treatment.
The Journal of biological chemistry 2000;275(14):10532-7.
2000: Kevin Gerrish; Maureen Gannon; D Shih; Eva Henderson; M Stoffel; Christopher V E Wright; Roland Stein
Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites.
The Journal of biological chemistry 2000;275(5):3485-92.
1999: A Sharma; M Moore; Edoardo Marcora; J E Lee; Yi Qiu; Susan E Samaras; Roland Stein
The NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/CREB binding protein binding.
Molecular and cellular biology 1999;19(1):704-13.
1998: Helle Vestergaard Petersen; M Peshavaria; Anette Amstrup Pedersen; J Philippe; Roland Stein; Ole D Madsen; Palle Serup
Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor.
FEBS letters 1998;431(3):362-6.
1998: Yi Qiu; A Sharma; Roland Stein
p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene.
Molecular and cellular biology 1998;18(5):2957-64.
1997: A Sharma; Eva Henderson; Laura Gamer; Y Zhuang; Roland Stein
Analysis of the role of E2A-encoded proteins in insulin gene transcription.
Molecular endocrinology (Baltimore, Md.) 1997;11(11):1608-17.
1997: K L Wu; Maureen Gannon; M Peshavaria; M F Offield; Eva Henderson; M Ray; A Marks; Laura Gamer; Christopher V E Wright; Roland Stein
Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene.
Molecular and cellular biology 1997;17(10):6002-13.
1997: M Peshavaria; Eva Henderson; A Sharma; Christopher V E Wright; Roland Stein
Functional characterization of the transactivation properties of the PDX-1 homeodomain protein.
Molecular and cellular biology 1997;17(7):3987-96.
1995: A Sharma; D Fusco-DeMane; Eva Henderson; S Efrat; Roland Stein
The role of the insulin control element and RIPE3b1 activators in glucose-stimulated transcription of the insulin gene.
Molecular endocrinology (Baltimore, Md.) 1995;9(11):1468-76.
1995: A Sharma; L K Olson; R P Robertson; Roland Stein
The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression.
Molecular endocrinology (Baltimore, Md.) 1995;9(9):1127-34.
1995: G L Robinson; Eva Henderson; ME Massari; Cornelis Murre; Roland Stein
c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products.
Molecular and cellular biology 1995;15(3):1398-404.
1994: G L Robinson; S R Cordle; Eva Henderson; P Anthony Weil; Gladys Teitelman; Roland Stein
Isolation and characterization of a novel transcription factor that binds to and activates insulin control element-mediated expression.
Molecular and cellular biology 1994;14(10):6704-14.
1994: M Peshavaria; L Gamer; Eva Henderson; Gladys Teitelman; Christopher V E Wright; Roland Stein
XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor.
Molecular endocrinology (Baltimore, Md.) 1994;8(6):806-16.
1994: A Sharma; Roland Stein
Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression.
Molecular and cellular biology 1994;14(2):871-9.
1994: Roland Stein; Eva Henderson; S R Cordle
Analysis of an insulin gene transcription control element. Positive and negative regulation appears to be mediated by different element sequences.
FEBS letters 1994;338(2):187-90.
1994: G L Robinson; M Peshavaria; Eva Henderson; S Y Shieh; M J Tsai; Gladys Teitelman; Roland Stein
Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription.
The Journal of biological chemistry 1994;269(4):2452-60.
1994: Eva Henderson; Roland Stein
c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control.
Molecular and cellular biology 1994;14(1):655-62.
1991: S R Cordle; J Whelan; Eva Henderson; H Masuoka; P Anthony Weil; Roland Stein
Insulin gene expression in nonexpressing cells appears to be regulated by multiple distinct negative-acting control elements.
Molecular and cellular biology 1991;11(5):2881-6.
1991: S R Cordle; Eva Henderson; H Masuoka; P Anthony Weil; Roland Stein
Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins.
Molecular and cellular biology 1991;11(3):1734-8.
1990: J Whelan; S R Cordle; Eva Henderson; P Anthony Weil; Roland Stein
Identification of a pancreatic beta-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene sequence.
Molecular and cellular biology 1990;10(4):1564-72.
1989: J Whelan; D Poon; P Anthony Weil; Roland Stein
Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements.
Molecular and cellular biology 1989;9(8):3253-9.