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Donald Steiner

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Donald F Steiner
Adventures with insulin in the islets of Langerhans.
Jeffrey Stein; Wieslawa M Milewski; Manami Hara; Donald F Steiner; Arunangsu Dey
GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1).
Gregory Vlacich; Martijn C Nawijn; Gene C Webb; Donald F Steiner
Pim3 negatively regulates glucose-stimulated insulin secretion.

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All Publications

2011: Donald F Steiner
Adventures with insulin in the islets of Langerhans.
The Journal of biological chemistry 2011;286(20):17399-421.
2011: Jeffrey Stein; Wieslawa M Milewski; Manami Hara; Donald F Steiner; Arunangsu Dey
GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1).
Islets 2011;3(1):21-34.
2010: Gregory Vlacich; Martijn C Nawijn; Gene C Webb; Donald F Steiner
Pim3 negatively regulates glucose-stimulated insulin secretion.
Islets 2010;2(5):308-17.
2010: German Kilimnik; Abraham Kim; Donald F Steiner; Theodore C Friedman; Manami Hara
Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of ß-cell regeneration.
Islets 2010;2(3):149-55.
2010: Soo-Young Park; Honggang Ye; Donald F Steiner; Graeme I Bell
Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted.
Biochemical and biophysical research communications 2010;391(3):1449-54.
2009: Donald F Steiner; S-Y Park; J Støy; Louis H Philipson; Graeme I Bell
A brief perspective on insulin production.
Diabetes, obesity & metabolism 2009;11 Suppl 4():189-96.
2009: Michael Kharouta; Kevin Miller; Abraham Kim; Pawel Wojcik; German Kilimnik; Arunangsu Dey; Donald F Steiner; Manami Hara
No mantle formation in rodent islets -- the prototype of islet revisited.
Diabetes research and clinical practice 2009;85(3):252-7.
2008: Jens F Rehfeld; Xiaorong Zhu; Christina Norrbom; Jens R Bundgaard; Anders H Johnsen; John E Nielsen; Jonas Vikesaa; Jeffrey Stein; Arunangsu Dey; Donald F Steiner; Lennart Friis-Hansen
Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.
The Biochemical journal 2008;415(1):35-43.
2008: Emma L Edghill; Sarah Flanagan; Ann-Marie Patch; Chris Boustred; Andrew Parrish; Beverley Shields; Maggie H Shepherd; Khalid Hussain; Ritika R Kapoor; Maciej Malecki; Michael J MacDonald; Julie Støy; Donald F Steiner; Louis H Philipson; Graeme I Bell; Andrew T Hattersley; Sian Ellard
Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.
Diabetes 2008;57(4):1034-42.
2007: Kun Huang; Shu Jin Chan; Qing-xin Hua; Ying-Chi Chu; Run-Ying Wang; Birgit Klaproth; Wenhua Jia; Jonathan Whittaker; Pierre De Meyts; Satoe H Nakagawa; Donald F Steiner; Panayotis G Katsoyannis; Michael A Weiss
The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice.
The Journal of biological chemistry 2007;282(48):35337-49.
2007: Julie Støy; Emma L Edghill; Sarah Flanagan; Honggang Ye; Veronica P Paz; Anna Pluzhnikov; Jennifer Below; M Geoffrey Hayes; Nancy J Cox; Gregory M Lipkind; Rebecca B Lipton; Siri Atma W Greeley; Ann-Marie Patch; Sian Ellard; Donald F Steiner; Andrew T Hattersley; Louis H Philipson; Graeme I Bell
Insulin gene mutations as a cause of permanent neonatal diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15040-4.
2007: Shu Jin Chan; Satoe Nakagawa; Donald F Steiner
Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer.
The Journal of biological chemistry 2007;282(18):13754-8.
2006: Xiaorong Zhu; Yun Cao; Keith Voogd; Keith Voodg; Donald F Steiner
On the processing of proghrelin to ghrelin.
The Journal of biological chemistry 2006;281(50):38867-70.
2006: Jeffrey Stein; Rohan Shah; Donald F Steiner; Arunangsu Dey
RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor.
The Biochemical journal 2006;400(1):209-15.
2006: Jeffrey Stein; Donald F Steiner; Arunangsu Dey
Processing of cocaine- and amphetamine-regulated transcript (CART) precursor proteins by prohormone convertases (PCs) and its implications.
Peptides 2006;27(8):1919-25.
2006: Jie Wang; Yun Cao; Ying Chen; Yimei Chen; Paul Gardner; Donald F Steiner
Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10636-41.
2006: Peter J Schlueter; Tricia Royer; Mohamed H Farah; Benjamin Laser; Shu Jin Chan; Donald F Steiner; Cunming Duan
Gene duplication and functional divergence of the zebrafish insulin-like growth factor 1 receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1230-2.
2006: Randi Ugleholdt; Marie-Louise H Poulsen; Peter J Holst; Jean-Claude Irminger; Cathrine Orskov; Jens Pedersen; Mette M Rosenkilde; Xiaorong Zhu; Donald F Steiner; Jens J Holst
Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.
The Journal of biological chemistry 2006;281(16):11050-7.
2005: Juan Peinado; Virginie Laurent; Sang-Nam Lee; Bonnie W Peng; John E Pintar; Donald F Steiner; Iris Lindberg
Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 and PC2 null phenotypes.
Endocrinology 2005;146(8):3438-44.
2005: Arunangsu Dey; Gregory M Lipkind; Yves Rouillé; Christina Norrbom; Jeffrey Stein; Chunling Zhang; Raymond Carroll; Donald F Steiner
Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon.
Endocrinology 2005;146(2):713-27.
2004: Gene C Webb; Arunangsu Dey; Jie Wang; Jeffrey Stein; Margaret Milewski; Donald F Steiner
Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets.
The Journal of biological chemistry 2004;279(30):31068-75.
2004: Li Ma; Vytautas P Bindokas; Andrey Kuznetsov; Christopher Rhodes; Lori B Hays; J Michael Edwardson; Kazuya Ueda; Donald F Steiner; Louis H Philipson
Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9266-71.
2004: Arunangsu Dey; Christina Norrbom; Xiaorong Zhu; Jeffrey Stein; Chunling Zhang; Kazuya Ueda; Donald F Steiner
Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone.
Endocrinology 2004;145(4):1961-71.
2004: Randi Ugleholdt; Xiaorong Zhu; Carolyn F Deacon; Cathrine Ørskov; Donald F Steiner; Jens J Holst
Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.
Endocrinology 2004;145(3):1349-55.
2004: Donald F Steiner
The proinsulin C-peptide--a multirole model.
Experimental diabesity research 2004;5(1):7-14.
2003: Jie Wang; Gene Webb; Yun Cao; Donald F Steiner
Contrasting patterns of expression of transcription factors in pancreatic alpha and beta cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12660-5.
2003: Jie Wang; Yun Cao; Donald F Steiner
Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element/ATF site of the proglucagon gene promoter.
The Journal of biological chemistry 2003;278(35):32899-904.
2003: Kazuya Ueda; Gregory M Lipkind; An Zhou; Xiaorong Zhu; Andrey Kuznetsov; Louis H Philipson; Paul Gardner; Chunling Zhang; Donald F Steiner
Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1).
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5622-7.
2003: Arunangsu Dey; Xiaorong Xhu; Raymond Carroll; Christopher W Turck; Jeffrey Stein; Donald F Steiner
Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3.
The Journal of biological chemistry 2003;278(17):15007-14.
2003: Valérie Lilla; Gene Webb; Katharina Rickenbach; Andres Maturana; Donald F Steiner; Philippe A Halban; Jean-Claude Irminger
Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines.
Endocrinology 2003;144(4):1368-79.
2002: Gunilla T Westermark; Sture Falkmer; Donald F Steiner; Shu Jin Chan; Ulla Engström; Per Westermark
Islet amyloid polypeptide is expressed in the pancreatic islet parenchyma of the teleostean fish, Myoxocephalus (cottus) scorpius.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2002;133(1):119-25.
2002: Xiaorong Zhu; An Zhou; Arunangsu Dey; Christina Norrbom; Raymond Carroll; Chunling Zhang; Virginie Laurent; Iris Lindberg; Randi Ugleholdt; Jens J Holst; Donald F Steiner
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10293-8.
2002: Xiaorong Zhu; Lelio Orci; Raymond Carroll; Christina Norrbom; Mariella Ravazzola; Donald F Steiner
Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10299-304.
2002: Virginie Laurent; A Kimble; B Peng; P Zhu; John E Pintar; Donald F Steiner; Iris Lindberg
Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3087-92.
2002: Gene C Webb; Murtaza S Akbar; Chongjian Zhao; Hewson H Swift; Donald F Steiner
Glucagon replacement via micro-osmotic pump corrects hypoglycemia and alpha-cell hyperplasia in prohormone convertase 2 knockout mice.
Diabetes 2002;51(2):398-405.
2001: M Furuta; An Zhou; G Webb; Raymond Carroll; Mariella Ravazzola; Lelio Orci; Donald F Steiner
Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice.
The Journal of biological chemistry 2001;276(29):27197-202.
2001: Gene C Webb; Murtaza S Akbar; Chongjian Zhao; Donald F Steiner
Expression profiling of pancreatic beta-cells: glucose regulation of secretory and metabolic pathway genes.
Diabetes 2001;50 Suppl 1():S135-6.
2000: Satoe H Nakagawa; H S Tager; Donald F Steiner
Mutational analysis of invariant valine B12 in insulin: implications for receptor binding.
Biochemistry 2000;39(51):15826-35.
2000: Gunilla T Westermark; Samuel Gebre-Medhin; Donald F Steiner; Per Westermark
Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP.
Molecular medicine (Cambridge, Mass.) 2000;6(12):998-1007.
2000: J Bass; C Turck; M Rouard; Donald F Steiner
Furin-mediated processing in the early secretory pathway: sequential cleavage and degradation of misfolded insulin receptors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11905-9.
2000: Gene C Webb; Murtaza S Akbar; Chongjian Zhao; Donald F Steiner
Expression profiling of pancreatic beta cells: glucose regulation of secretory and metabolic pathway genes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5773-8.
2000: Anthony A Oliva; Shu Jin Chan; Donald F Steiner
Evolution of the prohormone convertases: identification of a homologue of PC6 in the protochordate amphioxus.
Biochimica et biophysica acta 2000;1477(1-2):338-48.
2000: Donald F Steiner
New aspects of proinsulin physiology and pathophysiology.
Journal of pediatric endocrinology & metabolism : JPEM 2000;13(3):229-39.
2000: Seong-Hun Kim; Rong Wang; David J Gordon; J Bass; Donald F Steiner; Gopal Thinakaran; David G Lynn; Stephen C Meredith; Sangram S Sisodia
Familial British dementia: expression and metabolism of BRI.
Annals of the New York Academy of Sciences 2000;920():93-9.
2000: Gunilla T Westermark; Donald F Steiner; Samuel Gebre-Medhin; Ulla Engström; Per Westermark
Pro islet amyloid polypeptide (ProIAPP) immunoreactivity in the islets of Langerhans.
Upsala journal of medical sciences 2000;105(2):97-106.
1999: Seong-Hun Kim; Rong Wang; David J Gordon; J Bass; Donald F Steiner; David G Lynn; Gopal Thinakaran; Stephen C Meredith; Sangram S Sisodia
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.
Nature neuroscience 1999;2(11):984-8.
1999: An Zhou; G Webb; Xiangdong Zhu; Donald F Steiner
Proteolytic processing in the secretory pathway.
The Journal of biological chemistry 1999;274(30):20745-8.
1999: H Furukawa; R J Carroll; Hewson H Swift; Donald F Steiner
Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6.
Diabetes 1999;48(7):1395-401.
1999: M Rouard; J Bass; FLORIN GRIGORESCU; T P Garrett; Colin W Ward; Gregory M Lipkind; C Jaffiole; Donald F Steiner; Graeme I Bell
Congenital insulin resistance associated with a conformational alteration in a conserved beta-sheet in the insulin receptor L1 domain.
The Journal of biological chemistry 1999;274(26):18487-91.
1999: Gunilla T Westermark; Per Westermark; Decio L Eizirik; Claes Hellerström; N Fox; Donald F Steiner; Arne Andersson
Differences in amyloid deposition in islets of transgenic mice expressing human islet amyloid polypeptide versus human islets implanted into nude mice.
Metabolism: clinical and experimental 1999;48(4):448-54.
1999: Gregory M Lipkind; Donald F Steiner
Predicted structural alterations in proinsulin during its interactions with prohormone convertases.
Biochemistry 1999;38(3):890-6.
1998: K Johanning; Maria A Juliano; Luiz Juliano; Claude Lazure; NS Lamango; Donald F Steiner; Iris Lindberg
Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates.
The Journal of biological chemistry 1998;273(35):22672-80.
1998: SJ Duguay; Y Jin; Jeffrey Stein; A N Duguay; P Gardner; Donald F Steiner
Post-translational processing of the insulin-like growth factor-2 precursor. Analysis of O-glycosylation and endoproteolysis.
The Journal of biological chemistry 1998;273(29):18443-51.
1998: Gregory M Lipkind; An Zhou; Donald F Steiner
A model for the structure of the P domains in the subtilisin-like prohormone convertases.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7310-5.
1998: J Bass; G Chiu; Yair Argon; Donald F Steiner
Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization.
The Journal of cell biology 1998;141(3):637-46.
1998: An Zhou; S Martin; Gregory M Lipkind; J LaMendola; Donald F Steiner
Regulatory roles of the P domain of the subtilisin-like prohormone convertases.
The Journal of biological chemistry 1998;273(18):11107-14.
1998: W M Milewski; SJ Duguay; Shu Jin Chan; Donald F Steiner
Conservation of PDX-1 structure, function, and expression in zebrafish.
Endocrinology 1998;139(3):1440-9.
1998: M Furuta; Raymond Carroll; S Martin; Hewson H Swift; Mariella Ravazzola; Lelio Orci; Donald F Steiner
Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.
The Journal of biological chemistry 1998;273(6):3431-7.
1998: Donald F Steiner
The proprotein convertases.
Current opinion in chemical biology 1998;2(1):31-9.
1997: Shu Jin Chan; E M Plisetskaya; E Urbinati; Y Jin; Donald F Steiner
Expression of multiple insulin and insulin-like growth factor receptor genes in salmon gill cartilage.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12446-51.
1997: Donald F Steiner; Arthur H Rubenstein
Proinsulin C-peptide--biological activity?
Science (New York, N.Y.) 1997;277(5325):531-2.
1997: M Furuta; H Yano; An Zhou; Yves Rouillé; Jens J Holst; Raymond Carroll; Mariella Ravazzola; Lelio Orci; H Furuta; Donald F Steiner
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6646-51.
1997: I Pittman; Satoe H Nakagawa; H S Tager; Donald F Steiner
Maintenance of the B-chain beta-turn in [GlyB24] insulin mutants: a steady-state fluorescence anisotropy study.
Biochemistry 1997;36(12):3430-7.
1997: SJ Duguay; W M Milewski; B D Young; K Nakayama; Donald F Steiner
Processing of wild-type and mutant proinsulin-like growth factor-IA by subtilisin-related proprotein convertases.
The Journal of biological chemistry 1997;272(10):6663-70.
1997: J LaMendola; S K Martin; Donald F Steiner
Expression of PC3, carboxypeptidase E and enkephalin in human monocyte-derived macrophages as a tool for genetic studies.
FEBS letters 1997;404(1):19-22.
1997: Z Upton; Geoffrey L Francis; Shu Jin Chan; Donald F Steiner; John C Wallace; FJ Ballard
Evolution of insulin-like growth factor (IGF) function: production and characterization of recombinant hagfish IGF.
General and comparative endocrinology 1997;105(1):79-90.
1996: J Bass; Takeshi Kurose; M Pashmforoush; Donald F Steiner
Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro.
The Journal of biological chemistry 1996;271(32):19367-75.
1996: M Pashmforoush; S J Chan; Donald F Steiner
Structure and expression of the insulin-like peptide receptor from amphioxus.
Molecular endocrinology (Baltimore, Md.) 1996;10(7):857-66.
1996: Xiaoling Zhu; Y Rouille; N S Lamango; Donald F Steiner; Iris Lindberg
Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: a potential mechanism for its inactivation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4919-24.
1996: SJ Duguay; Jie Lai-Zhang; Donald F Steiner; Bruria Funkenstein; S J Chan
Developmental and tissue-regulated expression of IGF-I and IGF-II mRNAs in Sparus aurata.
Journal of molecular endocrinology 1996;16(2):123-32.
1996: Donald F Steiner; Y Rouillé; Q Gong; S Martin; Raymond Carroll; S J Chan
The role of prohormone convertases in insulin biosynthesis: evidence for inherited defects in their action in man and experimental animals.
Diabetes & metabolism 1996;22(2):94-104.
1996: Per Westermark; Z C Li; Gunilla T Westermark; A Leckström; Donald F Steiner
Effects of beta cell granule components on human islet amyloid polypeptide fibril formation.
FEBS letters 1996;379(3):203-6.
1995: Y Rouillé; S Martin; Donald F Steiner
Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.
The Journal of biological chemistry 1995;270(44):26488-96.
1995: Y Rouillé; SJ Duguay; K Lund; M Furuta; Q Gong; Gregory M Lipkind; Anthony A Oliva; S J Chan; Donald F Steiner
Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases.
Frontiers in neuroendocrinology 1995;16(4):322-61.
1995: SJ Duguay; S J Chan; Thomas Mommsen; Donald F Steiner
Divergence of insulin-like growth factors I and II in the elasmobranch, Squalus acanthias.
FEBS letters 1995;371(1):69-72.
1995: SJ Duguay; Jie Lai-Zhang; Donald F Steiner
Mutational analysis of the insulin-like growth factor I prohormone processing site.
The Journal of biological chemistry 1995;270(29):17566-74.
1995: Gregory M Lipkind; Q Gong; Donald F Steiner
Molecular modeling of the substrate specificity of prohormone convertases SPC2 and SPC3.
The Journal of biological chemistry 1995;270(22):13277-84.
1995: Louis H Philipson; Donald F Steiner
Pas de deux or more: the sulfonylurea receptor and K+ channels.
Science (New York, N.Y.) 1995;268(5209):372-3.
1995: Anthony A Oliva; Donald F Steiner; S J Chan
Proprotein convertases in amphioxus: predicted structure and expression of proteases SPC2 and SPC3.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3591-5.
1994: M Pashmforoush; Yasunao Yoshimasa; Donald F Steiner
Exon 11 enhances insulin binding affinity and tyrosine kinase activity of the human insulin proreceptor.
The Journal of biological chemistry 1994;269(51):32639-48.
1994: Tadashi Hanabusa; S Ohagi; J LaMendola; S J Chan; Donald F Steiner
Nucleotide sequence and analysis of the mouse SPC3 promoter region.
FEBS letters 1994;356(2-3):339-41.
1994: S K Martin; Raymond Carroll; M Benig; Donald F Steiner
Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans.
FEBS letters 1994;356(2-3):279-82.
1994: Takeshi Kurose; M Pashmforoush; Yasunao Yoshimasa; Raymond Carroll; G P Schwartz; G T Burke; P G Katsoyannis; Donald F Steiner
Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor.
The Journal of biological chemistry 1994;269(46):29190-7.
1994: F Qian; S J Chan; C Achkar; Donald F Steiner; A Frankfater
Transcriptional regulation of cathepsin B expression in B16 melanomas of varying metastatic potential.
Biochemical and biophysical research communications 1994;202(1):429-36.
1994: J M Zigman; Gunilla T Westermark; J LaMendola; Donald F Steiner
Expression of cone transducin, Gz alpha, and other G-protein alpha-subunit messenger ribonucleic acids in pancreatic islets.
Endocrinology 1994;135(1):31-7.
1994: L Fan; Gunilla T Westermark; S J Chan; Donald F Steiner
Altered gene structure and tissue expression of islet amyloid polypeptide in the chicken.
Molecular endocrinology (Baltimore, Md.) 1994;8(6):713-21.
1994: Y Rouillé; Gunilla T Westermark; S K Martin; Donald F Steiner
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3242-6.
1993: J M Zigman; Gunilla T Westermark; J LaMendola; E Boel; Donald F Steiner
Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system.
Endocrinology 1993;133(6):2508-14.
1993: T S Seo; Tadashi Hanabusa; S Ohagi; Donald F Steiner; Graeme I Bell
Dinucleotide repeat polymorphism in the NEC2 gene.
Human molecular genetics 1993;2(11):1983.
1993: H Oohashi; H Ohgawara; K Nanjo; Y Tasaka; Q P Cao; S J Chan; Arthur H Rubenstein; Donald F Steiner; Yasue Omori
Familial hyperproinsulinemia associated with NIDDM. A case study.
Diabetes care 1993;16(10):1340-6.
1993: L Fan; P Gardner; S J Chan; Donald F Steiner
Cloning and analysis of the gene encoding hummingbird proinsulin.
General and comparative endocrinology 1993;91(1):25-30.
1993: N Fox; J Schrementi; M Nishi; S Ohagi; S J Chan; J A Heisserman; Gunilla T Westermark; A Leckström; Per Westermark; Donald F Steiner
Human islet amyloid polypeptide transgenic mice as a model of non-insulin-dependent diabetes mellitus (NIDDM).
FEBS letters 1993;323(1-2):40-4.
1993: Q Gong; S J Chan; A S Bajkowski; Donald F Steiner; A Frankfater
Characterization of the cathepsin B gene and multiple mRNAs in human tissues: evidence for alternative splicing of cathepsin B pre-mRNA.
DNA and cell biology 1993;12(4):299-309.
1993: Donald F Steiner; N Fox; S P Smeekens; S Ohagi; Gunilla T Westermark; S J Chan
New molecular perspectives in islet hormone biosynthesis.
Biochemical Society transactions 1993;21(1):139-42.
1993: KC Herold; S Nagamatsu; John B Buse; P Kulsakdinun; Donald F Steiner
Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506.
Transplantation 1993;55(1):186-92.
1992: Donald F Steiner; D E James
Cellular and molecular biology of the beta cell.
Diabetologia 1992;35 Suppl 2():S41-8.
1992: Donald F Steiner; S P Smeekens; S Ohagi; S J Chan
The new enzymology of precursor processing endoproteases.
The Journal of biological chemistry 1992;267(33):23435-8.
1992: S J Chan; Anthony A Oliva; J LaMendola; A Grens; H Bode; Donald F Steiner
Conservation of the prohormone convertase gene family in metazoa: analysis of cDNAs encoding a PC3-like protein from hydra.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):6678-82.
1992: S Ohagi; J LaMendola; M M LeBeau; Rafael Espinosa; J Takeda; S P Smeekens; S J Chan; Donald F Steiner
Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4977-81.
1992: S Nagamatsu; Donald F Steiner
Altered glucose regulation of insulin biosynthesis in insulinoma cells: mouse beta TC3 cells secrete insulin-related peptides predominantly via a constitutive pathway.
Endocrinology 1992;130(2):748-54.
1992: M Nishi; Tokio Sanke; S Ohagi; K Ekawa; H Wakasaki; Kishio Nanjo; G I Bell; Donald F Steiner
Molecular biology of islet amyloid polypeptide.
Diabetes research and clinical practice 1992;15(1):37-44.
1992: S P Smeekens; S J Chan; Donald F Steiner
The biosynthesis and processing of neuroendocrine peptides: identification of proprotein convertases involved in intravesicular processing.
Progress in brain research 1992;92():235-46.
1992: S J Chan; S Nagamatsu; Q P Cao; Donald F Steiner
Structure and evolution of insulin and insulin-like growth factors in chordates.
Progress in brain research 1992;92():15-24.
1991: S Ohagi; M Nishi; Graeme I Bell; J W Ensinck; Donald F Steiner
Sequences of islet amyloid polypeptide precursors of an Old World monkey, the pig-tailed macaque (Macaca nemestrina), and the dog (Canis familiaris).
Diabetologia 1991;34(8):555-8.
1991: S Nagamatsu; M Nishi; Donald F Steiner
Biosynthesis of islet amyloid polypeptide. Elevated expression in mouse beta TC3 cells.
The Journal of biological chemistry 1991;266(21):13737-41.
1991: F Qian; A Frankfater; Donald F Steiner; A S Bajkowski; S J Chan
Characterization of multiple cathepsin B mRNAs in murine B16a melanoma.
Anticancer research 1991;11(4):1445-51.
1991: F Qian; A Frankfater; S J Chan; Donald F Steiner
The structure of the mouse cathepsin B gene and its putative promoter.
DNA and cell biology 1991;10(3):159-68.
1991: Donald F Steiner; S Ohagi; S Nagamatsu; Graeme I Bell; M Nishi
Is islet amyloid polypeptide a significant factor in pathogenesis or pathophysiology of diabetes?
Diabetes 1991;40(3):305-9.
1991: S Nagamatsu; S J Chan; S Falkmer; Donald F Steiner
Evolution of the insulin gene superfamily. Sequence of a preproinsulin-like growth factor cDNA from the Atlantic hagfish.
The Journal of biological chemistry 1991;266(4):2397-402.
1991: S P Smeekens; A S Avruch; J LaMendola; S J Chan; Donald F Steiner
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):340-4.
1991: Louis H Philipson; R E Hice; K Schaefer; J LaMendola; Graeme I Bell; D J Nelson; Donald F Steiner
Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):53-7.
1991: F Qian; S J Chan; Q M Gong; A S Bajkowski; Donald F Steiner; A Frankfater
The expression of cathepsin B and other lysosomal proteinases in normal tissues and in tumors.
Biomedica biochimica acta 1991;50(4-6):531-40.
1990: Louis H Philipson; K Schaefer; J LaMendola; Graeme I Bell; Donald F Steiner
Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4.
Nucleic acids research 1990;18(23):7160.
1990: S Ohagi; M Nishi; Donald F Steiner
Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide).
Nucleic acids research 1990;18(23):7159.
1990: S J Chan; Q P Cao; Donald F Steiner
Evolution of the insulin superfamily: cloning of a hybrid insulin/insulin-like growth factor cDNA from amphioxus.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9319-23.
1990: M Nishi; Graeme I Bell; Donald F Steiner
Sequence of a cDNA encoding Syrian hamster islet amyloid polypeptide precursor.
Nucleic acids research 1990;18(22):6726.
1990: Yasunao Yoshimasa; J I Paul; J Whittaker; Donald F Steiner
Effects of amino acid replacements within the tetrabasic cleavage site on the processing of the human insulin receptor precursor expressed in Chinese hamster ovary cells.
The Journal of biological chemistry 1990;265(28):17230-7.
1990: M Nishi; Graeme I Bell; Donald F Steiner
Islet amyloid polypeptide (amylin): no evidence of an abnormal precursor sequence in 25 type 2 (non-insulin-dependent) diabetic patients.
Diabetologia 1990;33(10):628-30.
1990: M Nishi; S Ohagi; Donald F Steiner
Novel putative protein tyrosine phosphatases identified by the polymerase chain reaction.
FEBS letters 1990;271(1-2):178-80.
1990: J I Paul; J Tavaré; R M Denton; Donald F Steiner
Baculovirus-directed expression of the human insulin receptor and an insulin-binding ectodomain.
The Journal of biological chemistry 1990;265(22):13074-83.
1990: M Nishi; Donald F Steiner
Cloning of complementary DNAs encoding islet amyloid polypeptide, insulin, and glucagon precursors from a New World rodent, the degu, Octodon degus.
Molecular endocrinology (Baltimore, Md.) 1990;4(8):1192-8.
1990: S Nagamatsu; R J Carroll; G M Grodsky; Donald F Steiner
Lack of islet amyloid polypeptide regulation of insulin biosynthesis or secretion in normal rat islets.
Diabetes 1990;39(7):871-4.
1990: Donald F Steiner; H S Tager; S J Chan; K Nanjo; T Sanke; Arthur H Rubenstein
Lessons learned from molecular biology of insulin-gene mutations.
Diabetes care 1990;13(6):600-9.
1990: M Nishi; T Sanke; S Nagamatsu; Graeme I Bell; Donald F Steiner
Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits.
The Journal of biological chemistry 1990;265(8):4173-6.
1990: S P Smeekens; Donald F Steiner
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.
The Journal of biological chemistry 1990;265(6):2997-3000.
1990: F Qian; A Frankfater; RV Miller; S J Chan; Donald F Steiner
Molecular cloning of rat precursor cathepsin H and the expression of five lysosomal cathepsins in normal tissues and in a rat carcinosarcoma.
The International journal of biochemistry 1990;22(12):1457-64.
1989: Q P Cao; SJ Duguay; EM Plisetskaya; Donald F Steiner; S J Chan
Nucleotide sequence and growth hormone-regulated expression of salmon insulin-like growth factor I mRNA.
Molecular endocrinology (Baltimore, Md.) 1989;3(12):2005-10.
1989: M Nishi; T Sanke; S Seino; R L Eddy; Yao-Shan Fan; M G Byers; TB Shows; Graeme I Bell; Donald F Steiner
Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history.
Molecular endocrinology (Baltimore, Md.) 1989;3(11):1775-81.
1989: F Qian; A S Bajkowski; Donald F Steiner; S J Chan; A Frankfater
Expression of five cathepsins in murine melanomas of varying metastatic potential and normal tissues.
Cancer research 1989;49(17):4870-5.
1989: M Nishi; S J Chan; S Nagamatsu; Graeme I Bell; Donald F Steiner
Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(15):5738-42.
1988: R J Carroll; R E Hammer; S J Chan; Hewson H Swift; Arthur H Rubenstein; Donald F Steiner
A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):8943-7.
1988: T Sanke; Graeme I Bell; C Sample; Arthur H Rubenstein; Donald F Steiner
An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing.
The Journal of biological chemistry 1988;263(33):17243-6.
1988: M Miyano; K Nanjo; S J Chan; T Sanke; M Kondo; Donald F Steiner
Use of in vitro DNA amplification to screen family members for an insulin gene mutation.
Diabetes 1988;37(7):862-6.
1988: Donald F Steiner; S J Chan
An overview of insulin evolution.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1988;20(7):443-4.
1988: S Seino; C D Blackstone; S J Chan; J Whittaker; Graeme I Bell; Donald F Steiner
Appalachian spring: variations on ancient gastro-entero-pancreatic themes in New World mammals.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1988;20(7):430-5.
1988: Yasunao Yoshimasa; S Seino; J Whittaker; T Kakehi; A Kosaki; Hideshi Kuzuya; Hiroshi Imura; Graeme I Bell; Donald F Steiner
Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing.
Science (New York, N.Y.) 1988;240(4853):784-7.
1988: C D Blackstone; S Seino; T Takeuchi; T Yamada; Donald F Steiner
Novel organization and processing of the guinea pig pancreatic polypeptide precursor.
The Journal of biological chemistry 1988;263(6):2911-6.
1987: J Michael; Raymond Carroll; Hewson H Swift; Donald F Steiner
Studies on the molecular organization of rat insulin secretory granules.
The Journal of biological chemistry 1987;262(34):16531-5.
1987: S Seino; Donald F Steiner; Graeme I Bell
Sequence of a New World primate insulin having low biological potency and immunoreactivity.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7423-7.
1987: C E Sample; Donald F Steiner
Tissue-specific binding of a nuclear factor to the insulin gene promoter.
FEBS letters 1987;222(2):332-6.