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Joseph Steiner

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Varsha Shukla; Joseph P Steiner; Ya-Li Zheng; Niranjana D Amin; Philip Grant; Sashi Kesavapany; Santosh K Mishra; Harish C Pant
A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice.
Samir Nath; Muznabanu Bachani; Deepti Harshavardhana; Joseph P Steiner
Catechins protect neurons against mitochondrial toxins and HIV proteins via activation of the BDNF pathway.
Hangxiu Xu; Mihyun Bae; Veera Bandaru; Neha Patel; Daniel Pomerantz; Joseph P Steiner; Luis B Tovar-y-Romo; Norman Haughey
The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.

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2013: Varsha Shukla; Joseph P Steiner; Ya-Li Zheng; Niranjana D Amin; Philip Grant; Sashi Kesavapany; Santosh K Mishra; Harish C Pant
A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(1):174-86.
2012: Samir Nath; Muznabanu Bachani; Deepti Harshavardhana; Joseph P Steiner
Catechins protect neurons against mitochondrial toxins and HIV proteins via activation of the BDNF pathway.
Journal of neurovirology 2012;18(6):445-55.
2011: Hangxiu Xu; Mihyun Bae; Veera Bandaru; Neha Patel; Daniel Pomerantz; Joseph P Steiner; Luis B Tovar-y-Romo; Norman Haughey
The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(47):17074-90.
2011: Katherine Conant; Caroline Krall; Irina Lonskaya; Kathleen Maguire-Zeiss; Joseph P Steiner; Arek Szklarczyk; Seung T Lim
Methamphetamine-associated cleavage of the synaptic adhesion molecule intercellular adhesion molecule-5.
Journal of neurochemistry 2011;118(4):521-32.
2011: Kylene Kehn-Hall; Irene Guendel; Lawrence Carpio; Leandros Skaltsounis; Laurent Meijer; Lena Al-Harthi; Joseph P Steiner; Avindra Nath; Olaf Kutsch; Fatah Kashanchi
Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors.
Virology 2011;415(1):56-68.
2011: Myoung-Hwa Lee; TONGGUANG WANG; Mi-Hyeon Jang; Joseph P Steiner; Norman Haughey; Guo-Li Ming; Hongjun Song; Avindra Nath; Arun Venkatesan
Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease.
Neurobiology of disease 2011;41(3):678-87.
2010: Joseph P Steiner; Kathryn B Payne; Christopher Drummond Main; Sabrina D'Alfonso; Kirsten X Jacobsen; T Philip Hicks; William A Staines; Michael O Poulter
GPI-1046 increases presenilin-1 expression and restores NMDA channel activity.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2010;37(4):457-67.
2010: justin charles mcarthur; Joseph P Steiner; Ned Sacktor; Avindra Nath
Human immunodeficiency virus-associated neurocognitive disorders: Mind the gap.
Annals of neurology 2010;67(6):699-714.
2010: E Kirches; Joseph P Steiner; T Schneider; C K Vorwerk; C Scherlach; N Holtkamp; G Keilhoff; C Eng; C Mawrin
Lhermitte-Duclos disease caused by a novel germline PTEN mutation R173P in a patient presenting with psychosis.
Neuropathology and applied neurobiology 2010;36(1):86-9.
2009: Wenxue Li; Guanhan Li; Joseph P Steiner; Avindra Nath
Role of Tat protein in HIV neuropathogenesis.
Neurotoxicity research 2009;16(3):205-20.
2009: S C Reingold; Joseph P Steiner; C H Polman; J A Cohen; M S Freedman; L Kappos; A J Thompson; J S Wolinsky
The challenge of follow-on biologics for treatment of multiple sclerosis.
Neurology 2009;73(7):552-9.
2008: Wenxue Li; Yan Huang; Rollie Reid; Joseph P Steiner; Tanya Malpica-Llanos; Thomas A Darden; Susarla K Shankar; Anita Mahadevan; Parthasarthy Satishchandra; Avindra Nath
NMDA receptor activation by HIV-Tat protein is clade dependent.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12190-8.
2008: Norman Haughey; Joseph P Steiner; Avindra Nath; justin charles mcarthur; Ned Sacktor; CARLOS PARDO-VILLAMIZAR; Veera Bandaru
Converging roles for sphingolipids and cell stress in the progression of neuro-AIDS.
Frontiers in bioscience : a journal and virtual library 2008;13():5120-30.
2007: Heather Valentine; Yi Chen; Hongzhi Guo; Jocelyn McCormick; Yong Wu; Sena F Sezen; Ahmet Hoke; Arthur L Burnett; Joseph P Steiner
Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: new experimental paradigms.
European urology 2007;51(6):1724-31.
2007: Joseph P Steiner; David Galey; Norman Haughey; Daniella Asch; Avindra Nath
Neuroprotective and antiretroviral effects of the immunophilin ligand GPI 1046.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2007;2(1):49-57.
2006: Joseph P Steiner; Norman Haughey; Wenxue Li; Arun Venkatesan; Caroline Anderson; Rollie Reid; Tanya Malpica; Chava B Pocernich; D Allan Butterfield; Avindra Nath
Oxidative stress and therapeutic approaches in HIV dementia.
Antioxidants & redox signaling 2006;8(11-12):2089-100.
2006: Shaji Theodore; Wayne A Cass; Avindra Nath; Joseph P Steiner; Kristie Young; William F Maragos
Inhibition of tumor necrosis factor-alpha signaling prevents human immunodeficiency virus-1 protein Tat and methamphetamine interaction.
Neurobiology of disease 2006;23(3):663-8.
2006: Emily Caporello; Avindra Nath; John Slevin; David Galey; Greg Hamilton; Larry Williams; Joseph P Steiner; Norman Haughey
The immunophilin ligand GPI1046 protects neurons from the lethal effects of the HIV-1 proteins gp120 and Tat by modulating endoplasmic reticulum calcium load.
Journal of neurochemistry 2006;98(1):146-55.
2006: TONGGUANG WANG; Rameeza Allie; Katherine Conant; Norman Haughey; Jadwiga Turchan-Chelowo; Katrin Hahn; Antony Rosen; Joseph P Steiner; Sanjay C Keswani; Melina Jones; Peter A Calabresi; Avindra Nath
Granzyme B mediates neurotoxicity through a G-protein-coupled receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1209-11.
2006: Raquelli Ganel; Ho W Tony; Nicholas J Maragakis; Mandy Jackson; Joseph P Steiner; Jeffrey rothstein
Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection.
Neurobiology of disease 2006;21(3):556-67.
2004: Ling Wei; Joseph P Steiner; Gregory S Hamilton; Yong-Qian Wu
Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives.
Bioorganic & medicinal chemistry letters 2004;14(17):4549-51.
2004: Michael O Poulter; K B Payne; Joseph P Steiner
Neuroimmunophilins: a novel drug therapy for the reversal of neurodegenerative disease?
Neuroscience 2004;128(1):1-6.
2003: Douglas E Wilkinson; Bert Thomas; David C Limburg; Agnes Holmes; Hansjorg Sauer; Douglas T Ross; Raj Soni; Yi Chen; Hong Guo; Pamela Howorth; Heather Valentine; Dawn Spicer; Mike Fuller; Joseph P Steiner; Gregory S Hamilton; Yong-Qian Wu
Synthesis, molecular modeling and biological evaluation of aza-proline and aza-pipecolic derivatives as FKBP12 ligands and their in vivo neuroprotective effects.
Bioorganic & medicinal chemistry 2003;11(22):4815-25.
2003: David C Limburg; Bert Thomas; Jia-He Li; Mike Fuller; Dawn Spicer; Yi Chen; Hongzhi Guo; Joseph P Steiner; Gregory S Hamilton; Yong-Qian Wu
Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands.
Bioorganic & medicinal chemistry letters 2003;13(21):3867-70.
2003: Yong-Qian Wu; Sergei Belyakov; Chi Choi; David C Limburg; Bert E Thomas IV; Mark Vaal; Ling Wei; Douglas E Wilkinson; Agnes Holmes; Mike Fuller; Jocelyn McCormick; Maureen Connolly; Tim Moeller; Joseph P Steiner; Gregory S Hamilton
Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
Journal of medicinal chemistry 2003;46(7):1112-5.
2003: Yong-Qian Wu; David C Limburg; Douglas E Wilkinson; Paul Jackson; Joseph P Steiner; Gregory S Hamilton; Sergei A Belyakov
Neuroprotective effects of inhibitors of dipeptidyl peptidase-iV in vitro and in vivo.
Advances in experimental medicine and biology 2003;524():351-5.
2002: Jamie L Eberling; Phillip Pivirotto; John Bringas; Joseph P Steiner; Jeffrey Kordower; Yaping Chu; Marina E Emborg; Krystof S Bankiewicz
The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys.
Experimental neurology 2002;178(2):236-42.
2002: Sena F Sezen; Seth Blackshaw; Joseph P Steiner; Arthur L Burnett
FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injury.
International journal of impotence research 2002;14(6):506-12.
2002: Yong-Qian Wu; Douglas E Wilkinson; David C Limburg; Jia-He Li; Hansjorg Sauer; Doug Ross; Shi Liang; Dawn Spicer; Heather Valentine; Mike Fuller; Hong Guo; Pamela Howorth; Raj Soni; Yi Chen; Joseph P Steiner; Gregory S Hamilton
Synthesis of ketone analogues of prolyl and pipecolyl ester FKBP12 ligands.
Journal of medicinal chemistry 2002;45(16):3558-68.
2002: Gregory S Hamilton; Yong-Qian Wu; David C Limburg; Douglas E Wilkinson; Mark Vaal; Jia-He Li; Christine Thomas; Wei Huang; Hansjorg Sauer; Douglas T Ross; Raj Soni; Yi Chen; Hongshi Guo; Pamela Howorth; Heather Valentine; Shi Liang; Dawn Spicer; Mike Fuller; Joseph P Steiner
Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects.
Journal of medicinal chemistry 2002;45(16):3549-57.
2002: Ling Wei; Yon- Qian Wu; Douglas E Wilkinson; Yi Chen; Raj Soni; Chad Scott; Douglas T Ross; Hong Guo; Pamela Howorth; Heather Valentine; Shi Liang; Dawn Spicer; Mike Fuller; Joseph P Steiner; Gregory S Hamilton
Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides.
Bioorganic & medicinal chemistry letters 2002;12(10):1429-33.
2002: Chi Choi; Jia-He Li; Mark Vaal; Christine Thomas; David C Limburg; Yong-Qian Wu; Yi Chen; Raj Soni; Chad Scott; Douglas T Ross; Hong Guo; Pamela Howorth; Heather Valentine; Shi Liang; Dawn Spicer; Mike Fuller; Joseph P Steiner; Gregory S Hamilton
Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(10):1421-8.
2002: Z Khan; G Ferrari; M Kasper; David A Tonge; Joseph P Steiner; Gregory S Hamilton; Phillip R Gordon-Weeks
The non-immunosuppressive immunophilin ligand GPI-1046 potently stimulates regenerating axon growth from adult mouse dorsal root ganglia cultured in Matrigel.
Neuroscience 2002;114(3):601-9.
2001: C Zhang; Joseph P Steiner; Gregory S Hamilton; T P Hicks; Michael O Poulter
Regeneration of dopaminergic function in 6-hydroxydopamine-lesioned rats by neuroimmunophilin ligand treatment.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(15):RC156.
2001: Marina E Emborg; P Shin; Ben Roitberg; Joseph G Sramek; Y Chu; Glenn T Stebbins; J S Hamilton; PD Suzdak; Joseph P Steiner; Jeffrey Kordower
Systemic administration of the immunophilin ligand GPI 1046 in MPTP-treated monkeys.
Experimental neurology 2001;168(1):171-82.
2001: Douglas T Ross; Hong Guo; Pamela Howorth; Yi Chen; Gregory S Hamilton; Joseph P Steiner
The small molecule FKBP ligand GPI 1046 induces partial striatal re-innervation after intranigral 6-hydroxydopamine lesion in rats.
Neuroscience letters 2001;297(2):113-6.
1999: Hansjorg Sauer; J M Francis; H Jiang; Gregory S Hamilton; Joseph P Steiner
Systemic treatment with GPI 1046 improves spatial memory and reverses cholinergic neuron atrophy in the medial septal nucleus of aged mice.
Brain research 1999;842(1):109-18.
1999: Jamie L Eberling; Krystof S Bankiewicz; Phillip Pivirotto; John Bringas; Kewie Chen; David Nowotnik; Joseph P Steiner; Thomas F Budinger; William J Jagust
Dopamine transporter loss and clinical changes in MPTP-lesioned primates.
Brain research 1999;832(1-2):184-7.
1998: Gregory S Hamilton; Joseph P Steiner
Immunophilins: beyond immunosuppression.
Journal of medicinal chemistry 1998;41(26):5119-43.
1998: Loren D Walensky; Ted M Dawson; Joseph P Steiner; DM Sabatini; Juan D Suarez; Gary R Klinefelter; Solomon H Snyder
The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility.
Molecular medicine (Cambridge, Mass.) 1998;4(8):502-14.
1998: Solomon H Snyder; DM Sabatini; MM Lai; Joseph P Steiner; Gregory S Hamilton; PD Suzdak
Neural actions of immunophilin ligands.
Trends in pharmacological sciences 1998;19(1):21-6.
1997: Joseph P Steiner; M A Connolly; Heather Valentine; Gregory S Hamilton; Ted M Dawson; Lynda D Hester; Solomon H Snyder
Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A.
Nature medicine 1997;3(4):421-8.
1997: Joseph P Steiner; Gregory S Hamilton; Douglas T Ross; Heather Valentine; Hong Guo; M A Connolly; Shi Liang; C Ramsey; Jia-He Li; W Huang; Pamela Howorth; Raj Soni; Mike Fuller; Hansjorg Sauer; A C Nowotnik; PD Suzdak
Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):2019-24.
1996: Joseph P Steiner; Ted M Dawson; MAJID FOTUHI; Solomon H Snyder
Immunophilin regulation of neurotransmitter release.
Molecular medicine (Cambridge, Mass.) 1996;2(3):325-33.
1995: ANDREW CAMERON; Joseph P Steiner; A J Roskams; S M Ali; Gabriele V Ronnett; Solomon H Snyder
Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux.
Cell 1995;83(3):463-72.
1995: JIE ZHANG; Joseph P Steiner
Nitric oxide synthase, immunophilins and poly(ADP-ribose) synthetase: novel targets for the development of neuroprotective drugs.
Neurological research 1995;17(4):285-8.
1995: Alan H Sharp; S J Loev; Gabriele Schilling; S H Li; Xiao-Jiang Li; J Bao; M V Wagster; J A Kotzuk; Joseph P Steiner; A Lo
Widespread expression of Huntington's disease gene (IT15) protein product.
Neuron 1995;14(5):1065-74.
1995: W E Lyons; Joseph P Steiner; Solomon H Snyder; Ted M Dawson
Neuronal regeneration enhances the expression of the immunophilin FKBP-12.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(4):2985-94.
1995: ANDREW CAMERON; Joseph P Steiner; DM Sabatini; Adam I Kaplin; Loren D Walensky; Solomon H Snyder
Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1784-8.
1995: Ted M Dawson; K Hung; Valina Dawson; Joseph P Steiner; Solomon H Snyder
Neuroprotective effects of gangliosides may involve inhibition of nitric oxide synthase.
Annals of neurology 1995;37(1):115-8.
1994: J L Dinerman; Joseph P Steiner; Ted M Dawson; Valina Dawson; Solomon H Snyder
Cyclic nucleotide dependent phosphorylation of neuronal nitric oxide synthase inhibits catalytic activity.
Neuropharmacology 1994;33(11):1245-51.
1994: Ted M Dawson; Joseph P Steiner; W E Lyons; MAJID FOTUHI; Mary E Blue; Solomon H Snyder
The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: relationship to calcineurin.
Neuroscience 1994;62(2):569-80.
1994: W E Lyons; Edwin George; Ted M Dawson; Joseph P Steiner; Solomon H Snyder
Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3191-5.
1993: D B Hirsch; Joseph P Steiner; Ted M Dawson; Alex Mammen; E Hayek; Solomon H Snyder
Neurotransmitter release regulated by nitric oxide in PC-12 cells and brain synaptosomes.
Current biology : CB 1993;3(11):749-54.
1993: Ted M Dawson; Joseph P Steiner; Valina Dawson; J L Dinerman; George R. Uhl; Solomon H Snyder
Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):9808-12.
1992: Joseph P Steiner; Ted M Dawson; MAJID FOTUHI; C E Glatt; Adele M Snowman; N Cohen; Solomon H Snyder
High brain densities of the immunophilin FKBP colocalized with calcineurin.
Nature 1992;358(6387):584-7.
1992: A A Khan; Joseph P Steiner; Michael G Klein; Martin F Schneider; Solomon H Snyder
IP3 receptor: localization to plasma membrane of T cells and cocapping with the T cell receptor.
Science (New York, N.Y.) 1992;257(5071):815-8.
1992: A A Khan; Joseph P Steiner; Solomon H Snyder
Plasma membrane inositol 1,4,5-trisphosphate receptor of lymphocytes: selective enrichment in sialic acid and unique binding specificity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2849-53.
1989: Joseph P Steiner; H T Walke; Vann Bennett
Calcium/calmodulin inhibits direct binding of spectrin to synaptosomal membranes.
The Journal of biological chemistry 1989;264(5):2783-91.
1988: S Supattapone; Sonye K Danoff; A Theibert; S K Joseph; Joseph P Steiner; Solomon H Snyder
Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8747-50.
1988: Joseph P Steiner; V Bennett
Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin.
The Journal of biological chemistry 1988;263(28):14417-25.
1988: Vann Bennett; K Gardner; Joseph P Steiner
Brain adducin: a protein kinase C substrate that may mediate site-directed assembly at the spectrin-actin junction.
The Journal of biological chemistry 1988;263(12):5860-9.
1988: Vann Bennett; J Davis; K Gardner; Joseph P Steiner
The spectrin-based membrane skeleton: extensions of the current paradigm.
Society of General Physiologists series 1988;43():101-9.
1987: Joseph P Steiner; K Gardner; A Baines; V Bennett
Synapsin I: a regulated synaptic vesicle organizing protein.
Brain research bulletin 1987;18(6):777-85.
1987: Joseph P Steiner; E Ling; V Bennett
Nearest neighbor analysis for brain synapsin I. Evidence from in vitro reassociation assays for association with membrane protein(s) and the Mr = 68,000 neurofilament subunit.
The Journal of biological chemistry 1987;262(2):905-14.