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Christian Steinkühler

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Chantal Paolini; Cristina M Failla; paola gallinari; Angela Orecchia; Giovanna Zambruno; Christian Steinkühler
Skin equivalents: a tool for the discovery and validation of pharmacodynamic biomarkers.
dante rotili; Christian Steinkühler; Domenico Tarantino; Paolo Mellini; Angela Nebbioso; Chantal Paolini; Riccardo Pezzi; Antti Poso; Lucia Altucci; Giorgia Botta; Ruggero De Maria; Manel Esteller; Mario Fraga; paola gallinari; Covadonga Huidobro; Maija Lahtela-Kakkonen; Ester Lara; Alessia Lenoci; Antonello Mai
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
dante rotili; Jörg Schemies; Christian Steinkühler; Domenico Tarantino; Ettore Novellino; Chantal Paolini; Lucia Altucci; Giorgia Botta; Vincenzo Carafa; Ruggero De Maria; Salvatore Di Maro; paola gallinari; Manfred Jung; Antonello Mai
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.

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All Publications

2013: Chantal Paolini; Cristina M Failla; paola gallinari; Angela Orecchia; Giovanna Zambruno; Christian Steinkühler
Skin equivalents: a tool for the discovery and validation of pharmacodynamic biomarkers.
Cancer investigation 2013;31(1):60-6.
2012: dante rotili; Christian Steinkühler; Domenico Tarantino; Paolo Mellini; Angela Nebbioso; Chantal Paolini; Riccardo Pezzi; Antti Poso; Lucia Altucci; Giorgia Botta; Ruggero De Maria; Manel Esteller; Mario Fraga; paola gallinari; Covadonga Huidobro; Maija Lahtela-Kakkonen; Ester Lara; Alessia Lenoci; Antonello Mai
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
Journal of medicinal chemistry 2012;55(24):10937-47.
2012: dante rotili; Jörg Schemies; Christian Steinkühler; Domenico Tarantino; Ettore Novellino; Chantal Paolini; Lucia Altucci; Giorgia Botta; Vincenzo Carafa; Ruggero De Maria; Salvatore Di Maro; paola gallinari; Manfred Jung; Antonello Mai
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.
Journal of medicinal chemistry 2012;55(18):8193-7.
2011: Jesus M Ontoria; Michael Rowley; Sergio Serafini; Christian Steinkühler; Caterina Torrisi; Hu Bin; Alberto Bresciani; Laura Llauger Bufi; Claudia Giomini; Wu Hao; Philip Jones
Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(18):5274-82.
2011: Ester Muraglia; Jesus M Ontoria; Maria Cecilia Palumbi; Michael Rowley; Christian Steinkühler; Caterina Torrisi; Danila Branca; Alberto Bresciani; Gabriella Dessole; Massimiliano Fonsi; Claudio Giuliano; Laura Llauger Bufi; Edith Monteagudo; Philip Jones
N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.
Bioorganic & medicinal chemistry letters 2011;21(18):5283-8.
2011: Savina Malancona; Michael Rowley; Rita Scarpelli; Christian Steinkühler; Sergio Altamura; Gessica Filocamo; Jose Ignacio Martin Hernando; Olaf Kinzel; Philip Jones
Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 1.
Bioorganic & medicinal chemistry letters 2011;21(15):4422-8.
2011: Olaf Kinzel; Savina Malancona; Edith Monteagudo; Maria Orsale; Maria Cecilia Palumbi; Vincenzo Pucci; Michael Rowley; Romina Sasso; Rita Scarpelli; Christian Steinkühler; Anna Alfieri; Sergio Altamura; Mirko Brunetti; Simone Bufali; Fabrizio Colaceci; Federica Ferrigno; Gessica Filocamo; Massimiliano Fonsi; paola gallinari; Jose Ignacio Martin Hernando; Philip Jones
Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2.
Bioorganic & medicinal chemistry letters 2011;21(15):4429-35.
2010: Gianluca Canettieri; Lucia Di Marcotullio; Azzura Greco; Sonia Coni; Laura Antonucci; Paola Infante; Laura Pietrosanti; enrico de smaele; Elisabetta Ferretti; Evelina Miele; Marianna Pelloni; Giuseppina De Simone; Emilia Maria Pedone; paola gallinari; Alessandra Giorgi; Christian Steinkühler; Luigi Vitagliano; Carlo Pedone; M Eugenià Schinin; Isabella Screpanti; Alberto Gulino
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.
Nature cell biology 2010;12(2):132-42.
2009: Jesus M Ontoria; Sergio Altamura; Annalise Di Marco; Federica Ferrigno; Ralph Laufer; Ester Muraglia; Maria Cecilia Palumbi; Michael Rowley; Rita Scarpelli; Carsten Schultz-Fademrecht; Sergio Serafini; Christian Steinkühler; Philip Jones
Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.
Journal of medicinal chemistry 2009;52(21):6782-9.
2009: Bruno CADOT; Mirko Brunetti; Sabina Coppari; Silvia Fedeli; Emanuele de Rinaldis; Claudio Dello Russo; paola gallinari; Raffaele De Francesco; Christian Steinkühler; Gessica Filocamo
Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells.
Cancer research 2009;69(15):6074-82.
2009: Gabriella Dessole; Danila Branca; Federica Ferrigno; Olaf Kinzel; Ester Muraglia; Maria Cecilia Palumbi; Michael Rowley; Sergio Serafini; Christian Steinkühler; Philip Jones
Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway.
Bioorganic & medicinal chemistry letters 2009;19(15):4191-5.
2009: Olaf Kinzel; Laura Llauger-Bufi; Giovanna Pescatore; Michael Rowley; Carsten Schultz-Fademrecht; Edith Monteagudo; Massimiliano Fonsi; Odalys Gonzalez Paz; Fabrizio Fiore; Christian Steinkühler; Philip Jones
Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.
Journal of medicinal chemistry 2009;52(11):3453-6.
2009: Barbara Attenni; Jesus M Ontoria; Cruz Jonathan; Michael Rowley; Carsten Schultz-Fademrecht; Christian Steinkühler; Philip Jones
Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.
Bioorganic & medicinal chemistry letters 2009;19(11):3081-4.
2009: paola gallinari; Philip Jones; Simonetta Pazzaglia; Gessica Filocamo; Christian Steinkühler
Smoothened antagonists: a promising new class of antitumor agents.
Expert opinion on drug discovery 2009;4(5):525-44.
2008: Rita Scarpelli; Annalise Di Marco; Federica Ferrigno; Ralph Laufer; Isabella Marcucci; Ester Muraglia; Jesus M Ontoria; Michael Rowley; Sergio Serafini; Christian Steinkühler; Philip Jones
Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(23):6078-82.
2008: Ester Muraglia; Sergio Altamura; Danila Branca; Ottavia Cecchetti; Federica Ferrigno; Maria Orsale; Maria Cecilia Palumbi; Michael Rowley; Rita Scarpelli; Christian Steinkühler; Philip Jones
2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(23):6083-7.
2008: Pasquale Gallo; Michael V G Latronico; Paolo Gallo; Serena Grimaldi; Francesco Borgia; Matilde Todaro; Philip Jones; paola gallinari; Raffaele De Francesco; Gennaro Ciliberto; Christian Steinkühler; Giovanni Esposito; Gianluigi Condorelli
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure.
Cardiovascular research 2008;80(3):416-24.
2008: Giovanna Pescatore; Olaf Kinzel; Barbara Attenni; Ottavia Cecchetti; Fabrizio Fiore; Massimiliano Fonsi; Michael Rowley; Carsten Schultz-Fademrecht; Sergio Serafini; Christian Steinkühler; Philip Jones
Optimization of a series of potent and selective ketone histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(20):5528-32.
2008: Matthew J Bottomley; Paola Lo Surdo; Paolo Di Giovine; Agostino Cirillo; Rita Scarpelli; Federica Ferrigno; Philip Jones; Petra Neddermann; Raffaele De Francesco; Christian Steinkühler; paola gallinari; Andrea Carfí
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain.
The Journal of biological chemistry 2008;283(39):26694-704.
2008: Philip Jones; Matthew J Bottomley; Andrea Carfí; Ottavia Cecchetti; Federica Ferrigno; Paola Lo Surdo; Jesus M Ontoria; Michael Rowley; Rita Scarpelli; Carsten Schultz-Fademrecht; Christian Steinkühler
2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(11):3456-61.
2008: Philip Jones; Sergio Altamura; Raffaele De Francesco; Odalys Gonzalez Paz; Olaf Kinzel; Giuseppe Mesiti; Edith Monteagudo; Giovanna Pescatore; Michael Rowley; Maria Verdirame; Christian Steinkühler
A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo.
Journal of medicinal chemistry 2008;51(8):2350-3.
2008: Philip Jones; Sergio Altamura; Raffaele De Francesco; paola gallinari; Armin Lahm; Petra Neddermann; Michael Rowley; Sergio Serafini; Christian Steinkühler
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Bioorganic & medicinal chemistry letters 2008;18(6):1814-9.
2008: Gabriela Paroni; Nadia Cernotta; Claudio Dello Russo; paola gallinari; Michele Pallaoro; Carmela Foti; Fabio Talamo; Laura Orsatti; Christian Steinkühler; Claudio Brancolini
PP2A regulates HDAC4 nuclear import.
Molecular biology of the cell 2008;19(2):655-67.
2008: Philip Jones; Christian Steinkühler
From natural products to small molecule ketone histone deacetylase inhibitors: development of new class specific agents.
Current pharmaceutical design 2008;14(6):545-61.
2007: Armin Lahm; Chantal Paolini; Michele Pallaoro; Maria Chiara Nardi; P Jones; Petra Neddermann; Sonia Sambucini; Matthew J Bottomley; Paola Lo Surdo; Andrea Carfí; Uwe Koch; Raffaele De Francesco; Christian Steinkühler; paola gallinari
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17335-40.
2007: Alessandro Vannini; Cinzia Volpari; paola gallinari; Philip Jones; Marco Mattu; Andrea Carfí; Raffaele De Francesco; Christian Steinkühler; Stefania Di Marco
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex.
EMBO reports 2007;8(9):879-84.
2007: paola gallinari; Stefania Di Marco; Phillip Jones; Michele Pallaoro; Christian Steinkühler
HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics.
Cell research 2007;17(3):195-211.
2006: Philip Jones; Sergio Altamura; Prasun K Chakravarty; Ottavia Cecchetti; Raffaele De Francesco; paola gallinari; Raffaele Ingenito; Peter T Meinke; Alessia Petrocchi; Michael Rowley; Rita Scarpelli; Sergio Serafini; Christian Steinkühler
A series of novel, potent, and selective histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(23):5948-52.
2006: G C Minetti; C Colussi; Raffaella Adami; Carlo Serra; Chiara Mozzetta; valeria parente; S Fortuni; Stefania Straino; Maurilio Sampaolesi; Monica Di Padova; Barbara Illi; paola gallinari; Christian Steinkühler; Maurizio C Capogrossi; Vittorio Sartorelli; Roberto Bottinelli; carlo gaetano; Pier Lorenzo Puri
Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors.
Nature medicine 2006;12(10):1147-50.
2006: Cristiana Foglietti; Gessica Filocamo; Enrico Cundari; Emanuele De Rinaldis; Armin Lahm; Riccardo Cortese; Christian Steinkühler
Dissecting the biological functions of Drosophila histone deacetylases by RNA interference and transcriptional profiling.
The Journal of biological chemistry 2006;281(26):17968-76.
2004: Jesus M Ontoria; Stefania Di Marco; Immacolata Conte; M Emilia Di Francesco; Cristina Gardelli; Uwe Koch; Victor G Matassa; Marco Poma; Christian Steinkühler; Cinzia Volpari; Steven Harper
The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease.
Journal of medicinal chemistry 2004;47(26):6443-6.
2004: Alessandro Vannini; Cinzia Volpari; Gessica Filocamo; Elena Caroli Casavola; Mirko Brunetti; Debora Renzoni; Prasun Chakravarty; Chantal Paolini; Raffaele De Francesco; paola gallinari; Christian Steinkühler; Stefania Di Marco
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(42):15064-9.
2004: Caterina Nardella; Christian Steinkühler
Radiolabeled heparan sulfate immobilized on microplate as substrate for the detection of heparanase activity.
Analytical biochemistry 2004;332(2):368-75.
2004: Caterina Nardella; Armin Lahm; Michele Pallaoro; Mirko Brunetti; Alessandro Vannini; Christian Steinkühler
Mechanism of activation of human heparanase investigated by protein engineering.
Biochemistry 2004;43(7):1862-73.
2003: Frank Narjes; Uwe Koch; Christian Steinkühler
Recent developments in the discovery of hepatitis C virus serine protease inhibitors--towards a new class of antiviral agents?
Expert opinion on investigational drugs 2003;12(2):153-63.
2003: Stefania Colarusso; Uwe Koch; Benjamin Gerlach; Christian Steinkühler; Raffaele De Francesco; Sergio Altamura; Victor G Matassa; Frank Narjes
Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling.
Journal of medicinal chemistry 2003;46(3):345-8.
2002: Christian Steinkühler; Gabriella Biasiol; Mauro Cerretani; Laura Di Renzo; Mirko Brunetti; Paolo Ingallinella; Raffaele De Francesco; Sergio Altamura
A scintillation proximity active site binding assay for the hepatitis C virus serine protease.
Analytical biochemistry 2002;307(1):99-104.
2002: Paolo Ingallinella; Daniela Fattori; Sergio Altamura; Christian Steinkühler; Uwe Koch; Daniel O Cicero; Renzo Bazzo; Riccardo Cortese; Elisabetta Bianchi; Antonello Pessi
Prime site binding inhibitors of a serine protease: NS3/4A of hepatitis C virus.
Biochemistry 2002;41(17):5483-92.
2002: Frank Narjes; Koehler F Konrad; Uwe Koch; Benjamin Gerlach; Stefania Colarusso; Christian Steinkühler; Mirko Brunetti; Sergio Altamura; Raffaele De Francesco; Victor G Matassa
A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.
Bioorganic & medicinal chemistry letters 2002;12(4):701-4.
2001: Michele Pallaoro; Armin Lahm; Gabriella Biasiol; Mirko Brunetti; Caterina Nardella; Laura Orsatti; Fabio Bonelli; Stefania Orrù; Frank Narjes; Christian Steinkühler
Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein.
Journal of virology 2001;75(20):9939-46.
2001: Christian Steinkühler; Uwe Koch; Frank Narjes; Victor G Matassa
Hepatitis C virus protease inhibitors: current progress and future challenges.
Current medicinal chemistry 2001;8(8):919-932.
2001: Uwe Koch; Gabriella Biasiol; Mirko Brunetti; Daniela Fattori; Michele Pallaoro; Christian Steinkühler
Role of charged residues in the catalytic mechanism of hepatitis C virus NS3 protease: electrostatic precollision guidance and transition-state stabilization.
Biochemistry 2001;40(3):631-40.
2000: Laura Pacini; alessandra vitelli; Gessica Filocamo; Linda Bartholomew; Mirko Brunetti; Anna Tramontano; Christian Steinkühler; Giovanni Migliaccio
In vivo selection of protease cleavage sites by using chimeric Sindbis virus libraries.
Journal of virology 2000;74(22):10563-70.
2000: Paolo Ingallinella; Elisabetta Bianchi; Raffaele Ingenito; Uwe Koch; Christian Steinkühler; Sergio Altamura; Antonello Pessi
Optimization of the P'-region of peptide inhibitors of hepatitis C virus NS3/4A protease.
Biochemistry 2000;39(42):12898-906.
2000: Daniela Fattori; A Urbani; Mirko Brunetti; Raffaele Ingenito; Antonello Pessi; K Prendergast; Frank Narjes; Victor G Matassa; Raffaele De Francesco; Christian Steinkühler
Probing the active site of the hepatitis C virus serine protease by fluorescence resonance energy transfer.
The Journal of biological chemistry 2000;275(20):15106-13.
2000: Frank Narjes; Mirko Brunetti; Stefania Colarusso; Benjamin Gerlach; Uwe Koch; Gabriella Biasiol; Daniela Fattori; Raffaele De Francesco; Victor G Matassa; Christian Steinkühler
Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease.
Biochemistry 2000;39(7):1849-61.
2000: Raffaele De Francesco; Petra Neddermann; Licia tomei; Christian Steinkühler; paola gallinari; Antonella Folgori
Biochemical and immunologic properties of the nonstructural proteins of the hepatitis C virus: implications for development of antiviral agents and vaccines.
Seminars in liver disease 2000;20(1):69-83.
2000: Raffaele De Francesco; Christian Steinkühler
Structure and function of the hepatitis C virus NS3-NS4A serine proteinase.
Current topics in microbiology and immunology 2000;242():149-69.
1999: F Martin; Christian Steinkühler; Mirko Brunetti; Antonello Pessi; Riccardo Cortese; Raffaele De Francesco; maurizio sollazzo
A loop-mimetic inhibitor of the HCV-NS3 protease derived from a minibody.
Protein engineering 1999;12(11):1005-11.
1999: Raffaele De Francesco; Antonello Pessi; Christian Steinkühler
Mechanisms of hepatitis C virus NS3 proteinase inhibitors.
Journal of viral hepatitis 1999;6 Suppl 1():23-30.
1999: Stefania Orrù; Fabrizio Dal Piaz; Annarita Casbarra; Gabriella Biasiol; Raffaele De Francesco; Christian Steinkühler; Piero Pucci
Conformational changes in the NS3 protease from hepatitis C virus strain Bk monitored by limited proteolysis and mass spectrometry.
Protein science : a publication of the Protein Society 1999;8(7):1445-54.
1999: Daniel O Cicero; Gaetano Barbato; Uwe Koch; Paolo Ingallinella; Elisabetta Bianchi; MC Nardi; Christian Steinkühler; Riccardo Cortese; Victor G Matassa; Raffaele De Francesco; Antonello Pessi; Renzo Bazzo
Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies.
Journal of molecular biology 1999;289(2):385-96.
1999: Gaetano Barbato; Daniel O Cicero; MC Nardi; Christian Steinkühler; Riccardo Cortese; Raffaele De Francesco; Renzo Bazzo
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism.
Journal of molecular biology 1999;289(2):371-84.
1999: paola gallinari; Chantal Paolini; D Brennan; C Nardi; Christian Steinkühler; Raffaele De Francesco
Modulation of hepatitis C virus NS3 protease and helicase activities through the interaction with NS4A.
Biochemistry 1999;38(17):5620-32.
1999: A Urbani; Gabriella Biasiol; Mirko Brunetti; Cinzia Volpari; Stefania Di Marco; maurizio sollazzo; S Orrú; Fabrizio Dal Piaz; Annarita Casbarra; Piero Pucci; C Nardi; paola gallinari; Raffaele De Francesco; Christian Steinkühler
Multiple determinants influence complex formation of the hepatitis C virus NS3 protease domain with its NS4A cofactor peptide.
Biochemistry 1999;38(16):5206-15.
1999: Mauro Cerretani; L Di Renzo; Sergio Serafini; alessandra vitelli; Nadia Gennari; Elisabetta Bianchi; Antonello Pessi; A Urbani; Stefano Colloca; Raffaele De Francesco; Christian Steinkühler; Sergio Altamura
A high-throughput radiometric assay for hepatitis C virus NS3 protease.
Analytical biochemistry 1999;266(2):192-7.
1998: Nazzareno Dimasi; A Pasquo; F Martin; Stefania Di Marco; Christian Steinkühler; Riccardo Cortese; maurizio sollazzo
Engineering, characterization and phage display of hepatitis C virus NS3 protease and NS4A cofactor peptide as a single-chain protein.
Protein engineering 1998;11(12):1257-65.
1998: F Martin; Nazzareno Dimasi; Cinzia Volpari; C Perrera; Stefania Di Marco; Mirko Brunetti; Christian Steinkühler; Raffaele De Francesco; maurizio sollazzo
Design of selective eglin inhibitors of HCV NS3 proteinase.
Biochemistry 1998;37(33):11459-68.
1998: paola gallinari; D Brennan; C Nardi; Mirko Brunetti; Licia tomei; Christian Steinkühler; Raffaele De Francesco
Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus.
Journal of virology 1998;72(8):6758-69.
1998: A Urbani; Renzo Bazzo; MC Nardi; Daniel O Cicero; Raffaele De Francesco; Christian Steinkühler; Gaetano Barbato
The metal binding site of the hepatitis C virus NS3 protease. A spectroscopic investigation.
The Journal of biological chemistry 1998;273(30):18760-9.
1998: Paolo Ingallinella; Sergio Altamura; Elisabetta Bianchi; Marina Taliani; Raffaele Ingenito; Riccardo Cortese; Raffaele De Francesco; Christian Steinkühler; Antonello Pessi
Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products.
Biochemistry 1998;37(25):8906-14.
1998: Christian Steinkühler; Gabriella Biasiol; Mirko Brunetti; A Urbani; Uwe Koch; Riccardo Cortese; Antonello Pessi; Raffaele De Francesco
Product inhibition of the hepatitis C virus NS3 protease.
Biochemistry 1998;37(25):8899-905.
1998: Raffaele De Francesco; Antonello Pessi; Christian Steinkühler
The hepatitis C virus NS3 proteinase: structure and function of a zinc-containing serine proteinase.
Antiviral therapy 1998;3(Suppl 3):99-109.
1998: A Pasquo; M C Nardi; Nazzareno Dimasi; Licia tomei; Christian Steinkühler; Paola Delmastro; Anna Tramontano; Raffaele De Francesco
Rational design and functional expression of a constitutively active single-chain NS4A-NS3 proteinase.
Folding & design 1998;3(6):433-41.
1997: Nazzareno Dimasi; F Martin; Cinzia Volpari; Mirko Brunetti; Gabriella Biasiol; Sergio Altamura; Riccardo Cortese; Raffaele De Francesco; Christian Steinkühler; maurizio sollazzo
Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires.
Journal of virology 1997;71(10):7461-9.
1997: Elisabetta Bianchi; A Urbani; Gabriella Biasiol; Mirko Brunetti; Antonello Pessi; Raffaele De Francesco; Christian Steinkühler
Complex formation between the hepatitis C virus serine protease and a synthetic NS4A cofactor peptide.
Biochemistry 1997;36(25):7890-7.
1997: Petra Neddermann; Licia tomei; Christian Steinkühler; paola gallinari; Anna Tramontano; Raffaele De Francesco
The nonstructural proteins of the hepatitis C virus: structure and functions.
Biological chemistry 1997;378(6):469-76.
1997: A Urbani; Elisabetta Bianchi; Frank Narjes; Anna Tramontano; Raffaele De Francesco; Christian Steinkühler; Antonello Pessi
Substrate specificity of the hepatitis C virus serine protease NS3.
The Journal of biological chemistry 1997;272(14):9204-9.
1996: Raffaele De Francesco; A Urbani; M C Nardi; Licia tomei; Christian Steinkühler; Anna Tramontano
A zinc binding site in viral serine proteinases.
Biochemistry 1996;35(41):13282-7.
1996: Christian Steinkühler; A Urbani; Licia tomei; Gabriella Biasiol; Mohinder K Sardana; Elisabetta Bianchi; Antonello Pessi; Raffaele De Francesco
Activity of purified hepatitis C virus protease NS3 on peptide substrates.
Journal of virology 1996;70(10):6694-700.
1996: M Taliani; Elisabetta Bianchi; F Narjes; M Fossatelli; A Urbani; Christian Steinkühler; Raffaele De Francesco; Antonello Pessi
A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates.
Analytical biochemistry 1996;240(1):60-7.
1996: Elisabetta Bianchi; Christian Steinkühler; M Taliani; A Urbani; R D Francesco; Antonello Pessi
Synthetic depsipeptide substrates for the assay of human hepatitis C virus protease.
Analytical biochemistry 1996;237(2):239-44.
1996: Christian Steinkühler; Licia tomei; Raffaele De Francesco
In vitro activity of hepatitis C virus protease NS3 purified from recombinant Baculovirus-infected Sf9 cells.
The Journal of biological chemistry 1996;271(11):6367-73.