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Ralph Steinman

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Scott Barbuto; Gaëlle Breton; Juliana Idoyaga; Maria P Longhi; Ralph M Steinman; Miquel Vila-Perelló; Tom W Muir
Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells.
Yoonkyung Do; Hyein Koh; Chae Gyu Park; Steven Park; David S Perlin; Bradford S Powell; Seongho Ryu; Arnaud M Didierlaurent; Ralph M Steinman
Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor.
Chae Gyu Park; Anthony Rodriguez; Haekyung Lee; Kenjiro Matsuno; Maggi Pack; Hisashi Ueta; Ralph M Steinman
Generation of anti-human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals.

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2013: Scott Barbuto; Gaëlle Breton; Juliana Idoyaga; Maria P Longhi; Ralph M Steinman; Miquel Vila-Perelló; Tom W Muir
Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells.
Nature chemical biology 2013;9(4):250-6.
2012: Yoonkyung Do; Hyein Koh; Chae Gyu Park; Steven Park; David S Perlin; Bradford S Powell; Seongho Ryu; Arnaud M Didierlaurent; Ralph M Steinman
Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor.
Vaccine 2012;30(45):6359-67.
2012: Chae Gyu Park; Anthony Rodriguez; Haekyung Lee; Kenjiro Matsuno; Maggi Pack; Hisashi Ueta; Ralph M Steinman
Generation of anti-human DEC205/CD205 monoclonal antibodies that recognize epitopes conserved in different mammals.
Journal of immunological methods 2012;377(1-2):15-22.
2012: Hiroaki Hemmi; Christopher Fiorese; Tsuneyasu Kaisho; Ashira Lubkin; Ines Matos; Masaki Noda; Ralph M Steinman; Koji Suda; Bei Wang; Neeha Zaidi; Lori Zbytnuik; Kenneth Zhang; Juliana Idoyaga
Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(3):1147-55.
2012: Leonia Bozzacco; Brian T Chait; Haiteng Deng; Jörn Dengjel; Victoria Küttner; Svetlana Mojsov; Ralph M Steinman; Christine Trumpfheller; Beatrix Ueberheide; Haiqiang Yu; Henry A Zebroski; Nawei Zhang; David Fenyö
Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein.
PloS one 2012;7(7):e41897.
2012: Bei Wang; Neeha Zaidi; Li Zhang; Li-Zhen He; Tibor Keler; Janelle M Y Kuroiwa; Ralph M Steinman
Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice.
Breast cancer research : BCR 2012;14(2):R39.
2012: Ralph M Steinman
Decisions about dendritic cells: past, present, and future.
Annual review of immunology 2012;30():1-22.
2011: Jae-Hoon Choi; Durga B Dandamudi; In-Hyuk Jung; Saurabh Mehandru; Goo Taeg Oh; Chae Gyu Park; Anthony Rodriguez; Klara Velinzon; Ji-Young Yoo; Cheolho Cheong; Ralph M Steinman
Flt3 signaling-dependent dendritic cells protect against atherosclerosis.
Immunity 2011;35(5):819-31.
2011: Uri Sela; Peter Olds; Andrew Park; Sarah J Schlesinger; Ralph M Steinman
Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice.
The Journal of experimental medicine 2011;208(12):2489-96.
2011: Marina Caskey; Angela Duque-Alarcon; Abdelali Filali-Mouhim; Jean-Philippe Goulet; Elias K Haddad; François Lefebvre; Annette Nelkenbaum; Li Pan; Sarah Pollak; Andres M Salazar; Sarah J Schlesinger; Gaëlle Breton; Mark J Cameron; Irina Shimeliovich; Ralph M Steinman; Christine Trumpfheller; Rafick-Pierre Sékaly
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans.
The Journal of experimental medicine 2011;208(12):2357-66.
2011: Leonia Bozzacco; Haiteng Deng; Jörn Dengjel; Svetlana Mojsov; Haiqiang Yu; Henry A Zebroski; Ralph M Steinman
Mass spectrometry analysis and quantitation of peptides presented on the MHC II molecules of mouse spleen dendritic cells.
Journal of proteome research 2011;10(11):5016-30.
2011: Juliana Idoyaga; Ralph M Steinman
SnapShot: Dendritic Cells.
Cell 2011;146(4):660-660.e2.
2011: Jad Maamary; Frida Array; Qinshan Gao; Adolfo García-Sastre; Ralph M Steinman; Peter Palese; Godwin Nchinda
Newcastle disease virus expressing a dendritic cell-targeted HIV gag protein induces a potent gag-specific immune response in mice.
Journal of virology 2011;85(5):2235-46.
2011: Juliana Idoyaga; Ashira Lubkin; Christopher Fiorese; Mireille H Lahoud; Irina Caminschi; Yaoxing Huang; Anthony Rodriguez; Björn E Clausen; Chae Gyu Park; Christine Trumpfheller; Ralph M Steinman
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(6):2384-9.
2010: Cheolho Cheong; Jae-Hoon Choi; Laura Vitale; Li-Zhen He; Christine Trumpfheller; Leonia Bozzacco; Yoonkyung Do; Godwin Nchinda; Sung Ho Park; Durga Bhavani Dandamudi; Elina Shrestha; Maggi Pack; Han-Woong Lee; Tibor Keler; Ralph M Steinman; Chae Gyu Park
Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody.
Blood 2010;116(19):3828-38.
2010: Cheolho Cheong; Ines Matos; Jae-Hoon Choi; Durga Bhavani Dandamudi; Elina Shrestha; M Paula Longhi; Kate L Jeffrey; Robert M Anthony; Courtney Kluger; Godwin Nchinda; Hyein Koh; Anthony Rodriguez; Juliana Idoyaga; Maggi Pack; Klara Velinzon; Chae Gyu Park; Ralph M Steinman
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas.
Cell 2010;143(3):416-29.
2010: Yoonkyung Do; Hyein Koh; Chae Gyu Park; Diana Dudziak; Patrick Seo; Saurabh Mehandru; Jae-Hoon Choi; Cheolho Cheong; Steven Park; David S Perlin; Bradford S Powell; Ralph M Steinman
Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague.
European journal of immunology 2010;40(10):2791-6.
2010: Cheolho Cheong; Ines Matos; Jae-Hoon Choi; Joseph D Schauer; Durga Bhavani Dandamudi; Elina Shrestha; Jessy A Makeyeva; Xiaojun Li; Pingwei Li; Ralph M Steinman; Chae Gyu Park
New monoclonal anti-mouse DC-SIGN antibodies reactive with acetone-fixed cells.
Journal of immunological methods 2010;360(1-2):66-75.
2010: Ralph M Steinman
Some active areas of DC research and their medical potential.
European journal of immunology 2010;40(8):2085-8.
2010: Nikolaus Romani; Martin Thurnher; Juliana Idoyaga; Ralph M Steinman; Vincent Flacher
Targeting of antigens to skin dendritic cells: possibilities to enhance vaccine efficacy.
Immunology and cell biology 2010;88(4):424-30.
2010: Godwin Nchinda; David Amadu; Christine Trumpfheller; Olga Mizenina; Klaus Uberla; Ralph M Steinman
Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8+ T cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):4281-6.
2010: Ralph M Steinman; Juliana Idoyaga
Features of the dendritic cell lineage.
Immunological reviews 2010;234(1):5-17.
2010: Vincent Flacher; Christoph H Tripp; Patrizia Stoitzner; Bernhard Haid; Susanne Ebner; Barbara Del Frari; Franz Koch; Chae Gyu Park; Ralph M Steinman; Juliana Idoyaga; Nikolaus Romani
Epidermal Langerhans cells rapidly capture and present antigens from C-type lectin-targeting antibodies deposited in the dermis.
The Journal of investigative dermatology 2010;130(3):755-62.
2010: Leonia Bozzacco; Christine Trumpfheller; Yaoxing Huang; Maria Paula Longhi; Irina Shimeliovich; Joseph D Schauer; Chae Gyu Park; Ralph M Steinman
HIV gag protein is efficiently cross-presented when targeted with an antibody towards the DEC-205 receptor in Flt3 ligand-mobilized murine DC.
European journal of immunology 2010;40(1):36-46.
2009: Bei Wang; Janelle Kuroiwa; Li-Zhen He; Anna Charalambous; Tibor Keler; Ralph M Steinman
The human cancer antigen mesothelin is more efficiently presented to the mouse immune system when targeted to the DEC-205/CD205 receptor on dendritic cells.
Annals of the New York Academy of Sciences 2009;1174():6-17.
2009: Ralph M Steinman
Some scientific and organizational challenges in cancer immunology.
Annals of the New York Academy of Sciences 2009;1174():1-5.
2009: Gaëlle Breton; Bader Yassine-Diab; Lillian Cohn; Mohamed-Rachid Boulassel; Jean-Pierre Routy; Rafick-Pierre Sékaly; Ralph M Steinman
siRNA knockdown of PD-L1 and PD-L2 in monocyte-derived dendritic cells only modestly improves proliferative responses to Gag by CD8(+) T cells from HIV-1-infected individuals.
Journal of clinical immunology 2009;29(5):637-45.
2009: Kayo Inaba; William J Swiggard; Ralph M Steinman; Nikolaus Romani; Gerold Schuler; Carine Brinster
Isolation of dendritic cells.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2009;Chapter 3():Unit 3.7.
2009: M Paula Longhi; Christine Trumpfheller; Juliana Idoyaga; Marina Caskey; Ines Matos; Courtney Kluger; Andres M Salazar; Marco COLONna; Ralph M Steinman
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant.
The Journal of experimental medicine 2009;206(7):1589-602.
2009: Sayuri Yamazaki; Ralph M Steinman
Dendritic cells as controllers of antigen-specific Foxp3+ regulatory T cells.
Journal of dermatological science 2009;54(2):69-75.
2009: Christiane Stahl-Hennig; Martin Eisenblätter; Edith Jasny; Tamara Rzehak; Klara Tenner-Racz; Christine Trumpfheller; Andres M Salazar; Klaus Uberla; Karen Nieto; Jürgen Kleinschmidt; Reiner Schulte; Lutz Gissmann; Martin Müller; Anna Sacher; Paul Racz; Ralph M Steinman; Mariagrazia Uguccioni; Ralf Ignatius
Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques.
PLoS pathogens 2009;5(4):e1000373.
2009: Jae-Hoon Choi; Yoonkyung Do; Cheolho Cheong; Hyein Koh; Silvia B Boscardin; Yong-Seok Oh; Leonia Bozzacco; Christine Trumpfheller; Chae Gyu Park; Ralph M Steinman
Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves.
The Journal of experimental medicine 2009;206(3):497-505.
2009: Juliana Idoyaga; Nao Suda; Koji Suda; Chae Gyu Park; Ralph M Steinman
Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1524-9.
2009: Hiroaki Hemmi; Juliana Idoyaga; Koji Suda; Nao Suda; Kathleen Kennedy; Masaki Noda; Alan Aderem; Ralph M Steinman
A new triggering receptor expressed on myeloid cells (Trem) family member, Trem-like 4, binds to dead cells and is a DNAX activation protein 12-linked marker for subsets of mouse macrophages and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(3):1278-86.
2008: Sayuri Yamazaki; Diana Dudziak; Gordon F Heidkamp; Christopher Fiorese; Anthony J Bonito; Kayo Inaba; Michel C Nussenzweig; Ralph M Steinman
CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6923-33.
2008: Ralph M Steinman
Dendritic cells in vivo: a key target for a new vaccine science.
Immunity 2008;29(3):319-24.
2008: Cagan Gurer; Till Strowig; Fabienne Brilot; Maggi Pack; Christine Trumpfheller; Frida Arrey; Chae Gyu Park; Ralph M Steinman; Christian Münz
Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses.
Blood 2008;112(4):1231-9.
2008: Karen Bulloch; Melinda M Miller; Judit Gal-Toth; Teresa A Milner; Andres Gottfried-Blackmore; Elizabeth M Waters; Ulrike W Kaunzner; Kang Liu; Randall Lindquist; Michel C Nussenzweig; Ralph M Steinman; Bruce S McEwen
CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain.
The Journal of comparative neurology 2008;508(5):687-710.
2008: Arunika Mukhopadhaya; Tadashi Hanafusa; Irene Jarchum; Yi-Guang Chen; Yoshiko Iwai; David V Serreze; Ralph M Steinman; Kristin V Tarbell; Teresa P DiLorenzo
Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6374-9.
2008: Godwin Nchinda; Janelle Kuroiwa; Margarita Oks; Christine Trumpfheller; Chae Gyu Park; Yaoxing Huang; Drew Hannaman; Sarah J Schlesinger; Olga Mizenina; Michel C Nussenzweig; Klaus Uberla; Ralph M Steinman
The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells.
The Journal of clinical investigation 2008;118(4):1427-36.
2008: Juliana Idoyaga; Cheolho Cheong; Koji Suda; Nao Suda; Jae Y Kim; Haekyung Lee; Chae Gyu Park; Ralph M Steinman
Cutting edge: langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):3647-50.
2008: Magdia De Jesus; Chae Gyu Park; Ya Su; David Goldman; Ralph M Steinman; Arturo Casadevall
Spleen deposition of Cryptococcus neoformans capsular glucuronoxylomannan in rodents occurs in red pulp macrophages and not marginal zone macrophages expressing the C-type lectin SIGN-R1.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2008;46(2):153-62.
2008: Maggi Pack; Christine Trumpfheller; Dolca Thomas; Chae Gyu Park; Angela Granelli-Piperno; Christian Münz; Ralph M Steinman
DEC-205/CD205+ dendritic cells are abundant in the white pulp of the human spleen, including the border region between the red and white pulp.
Immunology 2008;123(3):438-46.
2008: Sung Ho Park; Cheolho Cheong; Juliana Idoyaga; Jae Y Kim; Jae-Hoon Choi; Yoonkyung Do; Haekyung Lee; Jung Heon Jo; Yong-Seok Oh; Wonpil Im; Ralph M Steinman; Chae Gyu Park
Generation and application of new rat monoclonal antibodies against synthetic FLAG and OLLAS tags for improved immunodetection.
Journal of immunological methods 2008;331(1-2):27-38.
2008: Christine Trumpfheller; Marina Caskey; Godwin Nchinda; Maria Paula Longhi; Olga Mizenina; Yaoxing Huang; Sarah J Schlesinger; Marco COLONna; Ralph M Steinman
The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2574-9.
2008: Devi Banerjee; Phillip Matthews; Elyana Matayeva; Jacob L Kaufman; Ralph M Steinman; Kavita M Dhodapkar
Enhanced T-cell responses to glioma cells coated with the anti-EGF receptor antibody and targeted to activating FcgammaRs on human dendritic cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2008;31(2):113-20.
2008: Yoshiko Iwai; Hiroaki Hemmi; Olga Mizenina; Shoko Kuroda; Koji Suda; Ralph M Steinman
An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation.
PloS one 2008;3(6):e2404.
2008: Ralph M Steinman
Dendritic cells and vaccines.
Proceedings (Baylor University. Medical Center) 2008;21(1):3-8.
2008: Yoonkyung Do; Chae Gyu Park; Young-Sun Kang; Sung Ho Park; Rebecca M Lynch; Haekyung Lee; Bradford S Powell; Ralph M Steinman
Broad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC-205/CD205-positive mouse dendritic cells.
European journal of immunology 2008;38(1):20-9.
2007: Sayuri Yamazaki; Anthony J Bonito; Radek Spisek; Madhav V Dhodapkar; Kayo Inaba; Ralph M Steinman
Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors.
Blood 2007;110(13):4293-302.
2007: Ralph M Steinman
Dendritic cells: understanding immunogenicity.
European journal of immunology 2007;37 Suppl 1():S53-60.
2007: Ralph M Steinman
Lasker Basic Medical Research Award. Dendritic cells: versatile controllers of the immune system.
Nature medicine 2007;13(10):1155-9.
2007: Ralph M Steinman; Jacques Banchereau
Taking dendritic cells into medicine.
Nature 2007;449(7161):419-26.
2007: Lisa C Zaba; Judilyn Fuentes-Duculan; Ralph M Steinman; James G Krueger; Michelle A Lowes
Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages.
The Journal of clinical investigation 2007;117(9):2517-25.
2007: Cheolho Cheong; Juliana Idoyaga; Yoonkyung Do; Maggi Pack; Sung Ho Park; Haekyung Lee; Young-Sun Kang; Jae-Hoon Choi; Jae Y Kim; Anthony J Bonito; Kayo Inaba; Sayuri Yamazaki; Ralph M Steinman; Chae Gyu Park
Production of monoclonal antibodies that recognize the extracellular domain of mouse langerin/CD207.
Journal of immunological methods 2007;324(1-2):48-62.
2007: Kavita M Dhodapkar; Devi Banerjee; John Connolly; Anjli Kukreja; Elyana Matayeva; Maria-Concetta Veri; Jeffrey V Ravetch; Ralph M Steinman; Madhav V Dhodapkar
Selective blockade of the inhibitory Fcgamma receptor (FcgammaRIIB) in human dendritic cells and monocytes induces a type I interferon response program.
The Journal of experimental medicine 2007;204(6):1359-69.
2007: Helena Soares; HaeNa Waechter; Nicolas Glaichenhaus; Evelyne Mougneau; Hideo Yagita; Olga Mizenina; Diana Dudziak; Michel C Nussenzweig; Ralph M Steinman
A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo.
The Journal of experimental medicine 2007;204(5):1095-106.
2007: Xunrong Luo; Kristin V Tarbell; Hua Yang; Kathryn Pothoven; Samantha L Bailey; Ruchuang Ding; Ralph M Steinman; Manikkam Suthanthiran
Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2821-6.
2007: Leonia Bozzacco; Christine Trumpfheller; Frederick P Siegal; Saurabh Mehandru; Martin Markowitz; Mary Carrington; Michel C Nussenzweig; Angela Granelli Piperno; Ralph M Steinman
DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(4):1289-94.
2007: Kristin V Tarbell; Lucine Petit; Xiaopan Zuo; Priscilla Toy; Xunrong Luo; Amina Mqadmi; Hua Yang; Manikkam Suthanthiran; Svetlana Mojsov; Ralph M Steinman
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice.
The Journal of experimental medicine 2007;204(1):191-201.
2007: Diana Dudziak; Alice O Kamphorst; Gordon F Heidkamp; Veit R Buchholz; Christine Trumpfheller; Sayuri Yamazaki; Cheolho Cheong; Kang Liu; Han-Woong Lee; Chae Gyu Park; Ralph M Steinman; Michel C Nussenzweig
Differential antigen processing by dendritic cell subsets in vivo.
Science (New York, N.Y.) 2007;315(5808):107-11.
2007: Christiane Stahl-Hennig; Martin Eisenblatter; Monika Franz; Heribert Stoiber; Klara Tenner-Racz; You-Suk Suh; Edith Jasny; Barbara Falkensammer; Mariagrazia Ugucchioni; Gudmundur Georgsson; Carlo Baroni; Manfred P Dierich; Jeffrey D Lifson; Ralph M Steinman; Klaus Uberla; Paul Racz; Ralf Ignatius
A single vaccination with attenuated SIVmac 239 via the tonsillar route confers partial protection against challenge with SIVmac 251 at a distant mucosal site, the rectum.
Frontiers in bioscience : a journal and virtual library 2007;12():2107-23.
2006: Marjorie Pion; Angela Granelli-Piperno; Bastien Mangeat; Romaine Stalder; Rafael Correa; Ralph M Steinman; vincent piguet
APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection.
The Journal of experimental medicine 2006;203(13):2887-93.
2006: Anna Charalambous; Margarita Oks; Godwin Nchinda; Sayuri Yamazaki; Ralph M Steinman
Dendritic cell targeting of survivin protein in a xenogeneic form elicits strong CD4+ T cell immunity to mouse survivin.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8410-21.
2006: Devi K Banerjee; Madhav V Dhodapkar; Elyana Matayeva; Ralph M Steinman; Kavita M Dhodapkar
Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients.
Blood 2006;108(8):2655-61.
2006: Sayuri Yamazaki; Kayo Inaba; Kristin V Tarbell; Ralph M Steinman
Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity.
Immunological reviews 2006;212():314-29.
2006: Shin-Ichiro Fujii; Kanako Shimizu; Hiroaki Hemmi; Mikiko Fukui; Anthony J Bonito; Guangwu Chen; Richard W Franck; Moriya Tsuji; Ralph M Steinman
Glycolipid alpha-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11252-7.
2006: Seraphin Kuate; Christiane Stahl-Hennig; Heribert Stoiber; Godwin Nchinda; Anja Floto; Monika Franz; Ulrike Sauermann; Simon Bredl; Ludwig Deml; Ralf Ignatius; Stephen Norley; Paul Racz; Klara Tenner-Racz; Ralph M Steinman; Ralf Wagner; Klaus Uberla
Immunogenicity and efficacy of immunodeficiency virus-like particles pseudotyped with the G protein of vesicular stomatitis virus.
Virology 2006;351(1):133-44.
2006: Young-Sun Kang; Yoonkyung Do; Hae-Kyung Lee; Sung Ho Park; Cheolho Cheong; Rebecca M Lynch; Jutta M Loeffler; Ralph M Steinman; Chae Gyu Park
A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q.
Cell 2006;125(1):47-58.
2006: Kristin V Tarbell; Sayuri Yamazaki; Ralph M Steinman
The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity.
Seminars in immunology 2006;18(2):93-102.
2006: Christine Trumpfheller; Jennifer S Finke; Carolina B López; Thomas M Moran; Bruno Moltedo; Helena Soares; Yaoxing Huang; Sarah J Schlesinger; Chae Gyu Park; Michel C Nussenzweig; Angela Granelli-Piperno; Ralph M Steinman
Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine.
The Journal of experimental medicine 2006;203(3):607-17.
2006: Silvia B Boscardin; Julius Hafalla; Revati F Masilamani; Alice O Kamphorst; Henry A Zebroski; Urvashi Rai; Alexandre Morrot; Fidel Zavala; Ralph M Steinman; Ruth S Nussenzweig; Michel C Nussenzweig
Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses.
The Journal of experimental medicine 2006;203(3):599-606.
2006: Sayuri Yamazaki; Munjal Patel; Alice Harper; Anthony J Bonito; Hidehiro Fukuyama; Maggi Pack; Kristin V Tarbell; Mia Talmor; Jeffrey V Ravetch; Kayo Inaba; Ralph M Steinman
Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2758-63.
2006: Angela Granelli-Piperno; Irina Shimeliovich; Maggi Pack; Christine Trumpfheller; Ralph M Steinman
HIV-1 selectively infects a subset of nonmaturing BDCA1-positive dendritic cells in human blood.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):991-8.
2006: Ralph M Steinman
Linking innate to adaptive immunity through dendritic cells.
Novartis Foundation symposium 2006;279():101-9; discussion 109-13, 216-9.
2006: Ralph M Steinman; H Hemmi
Dendritic cells: translating innate to adaptive immunity.
Current topics in microbiology and immunology 2006;311():17-58.
2005: Michelle A Lowes; Francesca Chamian; Maria Veronica Abello; Judilyn Fuentes-Duculan; Shao-Lee Lin; RACHEL NUSSBAUM; Inna Novitskaya; Henrietta Carbonaro; Irma Cardinale; Toyoko Kikuchi; Patricia Gilleaudeau; Mary Sullivan-Whalen; Knut M Wittkowski; Kim A Papp; Marvin Garovoy; Wolfgang Dummer; Ralph M Steinman; James G Krueger
Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a).
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19057-62.
2005: Kang Liu; Juliana Idoyaga; Anna Charalambous; Shin-Ichiro Fujii; Anthony J Bonito; Jose Mordoh; Rosa Wainstok; Xue-Feng Bai; Yang Liu; Ralph M Steinman
Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells.
The Journal of experimental medicine 2005;202(11):1507-16.
2005: Kavita M Dhodapkar; Devi Banerjee; Ralph M Steinman
Harnessing the immune system against human glioma.
Annals of the New York Academy of Sciences 2005;1062():13-21.
2005: Angela Granelli-Piperno; Alla Pritsker; Maggi Pack; Irina Shimeliovich; Jean-François Arrighi; Chae Gyu Park; Christine Trumpfheller; vincent piguet; Thomas M Moran; Ralph M Steinman
Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4265-73.
2005: Marion Subklewe; Kathrin Sebelin; Andrea Block; Antje Meier; Anna Roukens; Casper Paludan; Jean-François Fonteneau; Ralph M Steinman; Christian Münz
Dendritic cells expand Epstein Barr virus specific CD8+ T cell responses more efficiently than EBV transformed B cells.
Human immunology 2005;66(9):938-49.
2005: Christian Münz; Ralph M Steinman; Shin-ichiro Fujii
Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity.
The Journal of experimental medicine 2005;202(2):203-7.
2005: Koji Nagaoka; Kazuhiko Takahara; Kay Tanaka; Hideo Yoshida; Ralph M Steinman; Shin-Ichiro Saitoh; Sachiko Akashi-Takamura; Kensuke Miyake; Young-Sun Kang; Chae Gyu Park; Kayo Inaba
Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria.
International immunology 2005;17(7):827-36.
2005: Clare L Bennett; Erwin van Rijn; Steffen Jung; Kayo Inaba; Ralph M Steinman; Martien L Kapsenberg; Björn E Clausen
Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity.
The Journal of cell biology 2005;169(4):569-76.
2005: Gunther Hartmann; Anja Marschner; Pablo Renner Viveros; Christiane Stahl-Hennig; Martin Eisenblätter; You-Suk Suh; Stefan Endres; Klara Tenner-Racz; Klaus Uberla; Paul Racz; Ralph M Steinman; Ralf Ignatius
CpG oligonucleotides induce strong humoral but only weak CD4+ T cell responses to protein antigens in rhesus macaques in vivo.
Vaccine 2005;23(25):3310-7.
2005: David H Chang; Keren Osman; John Connolly; Anjli Kukreja; Joseph Krasovsky; Maggi Pack; Aisha Hutchinson; Matthew D Geller; Nancy Liu; Rebecca Annable; Jennifer Shay; Kelly Kirchhoff; Nobusuke Nishi; Yoshitaka Ando; Kunihiko Hayashi; Hani Hassoun; Ralph M Steinman; Madhav V Dhodapkar
Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients.
The Journal of experimental medicine 2005;201(9):1503-17.
2005: Kavita M Dhodapkar; Jacob L Kaufman; Marc Ehlers; Devi K Banerjee; Ezio Bonvini; Scott Koenig; Ralph M Steinman; Jeffrey V Ravetch; Madhav V Dhodapkar
Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2910-5.
2005: Ralph M Steinman; Laura Bonifaz; Shin-ichiro Fujii; Kang Liu; David Bonnyay; Sayuri Yamazaki; Maggi Pack; Daniel Hawiger; Tomonori Iyoda; Kayo Inaba; Michel C Nussenzweig
The innate functions of dendritic cells in peripheral lymphoid tissues.
Advances in experimental medicine and biology 2005;560():83-97.
2005: Geraldine Arrode; Jennifer S Finke; Henry Zebroski; Frederick P Siegal; Ralph M Steinman
CD8+ T cells from most HIV-1-infected patients, even when challenged with mature dendritic cells, lack functional recall memory to HIV gag but not other viruses.
European journal of immunology 2005;35(1):159-70.
2004: Jennifer S Finke; Michael Shodell; Kokila Shah; Frederick P Siegal; Ralph M Steinman
Dendritic cell numbers in the blood of HIV-1 infected patients before and after changes in antiretroviral therapy.
Journal of clinical immunology 2004;24(6):647-52.
2004: Ralph M Steinman
Dendritic cells: from the fabric of immunology.
Clinical and investigative medicine. Médecine clinique et experimentale 2004;27(5):231-6.
2004: Martin Eisenblätter; Christiane Stahl-Hennig; Seraphin Kuate; Nicole Stolte; Edith Jasny; Helmut Hahn; Melissa Pope; Klara Tenner-Racz; Paul Racz; Ralph M Steinman; Klaus Uberla; Ralf Ignatius
Induction of neutralising antibodies restricts the use of human granulocyte/macrophage colony stimulating factor for vaccine studies in rhesus macaques.
Vaccine 2004;22(25-26):3295-302.
2004: Ralph M Steinman; Ira Mellman
Immunotherapy: bewitched, bothered, and bewildered no more.
Science (New York, N.Y.) 2004;305(5681):197-200.
2004: Shin-Ichiro Fujii; Kang Liu; Caroline Smith; Anthony J Bonito; Ralph M Steinman
The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation.
The Journal of experimental medicine 2004;199(12):1607-18.
2004: Kristin V Tarbell; Sayuri Yamazaki; Kara Olson; Priscilla Toy; Ralph M Steinman
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.
The Journal of experimental medicine 2004;199(11):1467-77.
2004: Kazuhiko Takahara; Yusuke Yashima; Yoshiki Omatsu; Hideo Yoshida; Yukino Kimura; Young-Sun Kang; Ralph M Steinman; Chae Gyu Park; Kayo Inaba
Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins.
International immunology 2004;16(6):819-29.
2004: Angela Granelli-Piperno; Angelika Golebiowska; Christine Trumpfheller; Frederick P Siegal; Ralph M Steinman
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7669-74.
2004: Kavita M Dhodapkar; Barbara Cirignano; Francesca Chamian; David Zagzag; Douglas C Miller; Jonathan Lester Finlay; Ralph M Steinman
Invariant natural killer T cells are preserved in patients with glioma and exhibit antitumor lytic activity following dendritic cell-mediated expansion.
International journal of cancer. Journal international du cancer 2004;109(6):893-9.
2004: Laura Bonifaz; David Bonnyay; Anna Charalambous; Dara I Darguste; Shin-Ichiro Fujii; Helena Soares; Marie K Brimnes; Bruno Moltedo; Thomas M Moran; Ralph M Steinman
In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination.
The Journal of experimental medicine 2004;199(6):815-24.
2004: Young-Sun Kang; Jae Y Kim; Sandra A Bruening; Maggi Pack; Anna Charalambous; Alla Pritsker; Thomas M Moran; Jutta M Loeffler; Ralph M Steinman; Chae Gyu Park
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):215-20.
2003: Kara Bickham; Kiera Goodman; Casper Paludan; Sarah Nikiforow; Ming L Tsang; Ralph M Steinman; Christian Münz
Dendritic cells initiate immune control of epstein-barr virus transformation of B lymphocytes in vitro.
The Journal of experimental medicine 2003;198(11):1653-63.
2003: A Karolina Palucka; Madhav V Dhodapkar; Sophie Paczesny; Susan Burkeholder; Knut M Wittkowski; Ralph M Steinman; Joseph Fay; Jacques Banchereau
Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2003;26(5):432-9.
2003: Mikael C I Karlsson; Rodolphe Guinamard; Silvia Bolland; Marko Sankala; Ralph M Steinman; Jeffrey V Ravetch
Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone.
The Journal of experimental medicine 2003;198(2):333-40.
2003: Shin-Ichiro Fujii; Kanako Shimizu; Caroline Smith; Laura Bonifaz; Ralph M Steinman
Activation of natural killer T cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein.
The Journal of experimental medicine 2003;198(2):267-79.
2003: Sayuri Yamazaki; Tomonori Iyoda; Kristin V Tarbell; Kara Olson; Klara Velinzon; Kayo Inaba; Ralph M Steinman
Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells.
The Journal of experimental medicine 2003;198(2):235-47.
2003: Marie K Brimnes; Laura Bonifaz; Ralph M Steinman; Thomas M Moran
Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein.
The Journal of experimental medicine 2003;198(1):133-44.
2003: Ralph M Steinman
Some interfaces of dendritic cell biology.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003;111(7-8):675-97.
2003: Boonrat Tassaneetrithep; Timothy Burgess; Angela Granelli-Piperno; Christine Trumpfheller; Jennifer Finke; Wellington Sun; Michael A Eller; Kovit Pattanapanyasat; Suttipant Sarasombath; Deborah L Birx; Ralph M Steinman; Sarah J Schlesinger; Mary A Marovich
DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells.
The Journal of experimental medicine 2003;197(7):823-9.
2003: Ralph M Steinman; Daniel Hawiger; Kang Liu; Laura Bonifaz; David Bonnyay; Karsten Mahnke; Tomonori Iyoda; Jeffrey V Ravetch; Madhav V Dhodapkar; Kayo Inaba; Michel C Nussenzweig
Dendritic cell function in vivo during the steady state: a role in peripheral tolerance.
Annals of the New York Academy of Sciences 2003;987():15-25.
2003: Gerold Schuler; Beatrice Schuler-Thurner; Ralph M Steinman
The use of dendritic cells in cancer immunotherapy.
Current opinion in immunology 2003;15(2):138-47.
2003: Ralph M Steinman
The control of immunity and tolerance by dendritic cell.
Pathologie-biologie 2003;51(2):59-60.
2003: Christine Trumpfheller; Chae Gyu Park; Jennifer Finke; Ralph M Steinman; Angela Granelli-Piperno
Cell type-dependent retention and transmission of HIV-1 by DC-SIGN.
International immunology 2003;15(2):289-98.
2003: Young-Sun Kang; Sayuri Yamazaki; Tomonori Iyoda; Maggi Pack; Sandra A Bruening; Jae Y Kim; Kazuhiko Takahara; Kayo Inaba; Ralph M Steinman; Chae Gyu Park
SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran.
International immunology 2003;15(2):177-86.
2003: Shin-ichiro Fujii; Kanako Shimizu; Ralph M Steinman; Madhav V Dhodapkar
Detection and activation of human Valpha24+ natural killer T cells using alpha-galactosyl ceramide-pulsed dendritic cells.
Journal of immunological methods 2003;272(1-2):147-59.
2003: Ralph M Steinman; Angela Granelli-Piperno; Melissa Pope; Christine Trumpfheller; Ralf Ignatius; Geraldine Arrode; Paul Racz; Klara Tenner-Racz
The interaction of immunodeficiency viruses with dendritic cells.
Current topics in microbiology and immunology 2003;276():1-30.
2003: Ralph M Steinman; Daniel Hawiger; Michel C Nussenzweig
Tolerogenic dendritic cells.
Annual review of immunology 2003;21():685-711.
2002: Laura Bonifaz; David Bonnyay; Karsten Mahnke; Miguel Rivera; Michel C Nussenzweig; Ralph M Steinman
Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance.
The Journal of experimental medicine 2002;196(12):1627-38.
2002: Mary A Marovich; John R Mascola; Michael A Eller; Mark K Louder; Pierre A Caudrelier; Raphaelle El Habib; Silvia Ratto-Kim; Josephine H Cox; Jeffrey R Currier; Bruce L Levine; Carl H June; Wendy B Bernstein; Merlin L Robb; Beatrice Schuler-Thurner; Ralph M Steinman; Deborah L Birx; Sarah Schlesinger-Frankel
Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells.
The Journal of infectious diseases 2002;186(9):1242-52.
2002: Kang Liu; Tomonori Iyoda; Marzena Saternus; Yukino Kimura; Kayo Inaba; Ralph M Steinman
Immune tolerance after delivery of dying cells to dendritic cells in situ.
The Journal of experimental medicine 2002;196(8):1091-7.
2002: Davorka Messmer; Jean-Marc Jacqué; Christine Santisteban; Cynthia Bristow; Seol-Young Han; Lorley Villamide-Herrera; Erin Mehlhop; Preston A Marx; Ralph M Steinman; Agegnehu Gettie; Melissa Pope
Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4172-82.
2002: Ralf Ignatius; Klara Tenner-Racz; Davorka Messmer; Agegnehu Gettie; James Blanchard; Amara Luckay; Christine Russo; Stephen Smith; Preston A Marx; Ralph M Steinman; Paul Racz; Melissa Pope
Increased macrophage infection upon subcutaneous inoculation of rhesus macaques with simian immunodeficiency virus-loaded dendritic cells or T cells but not with cell-free virus.
Journal of virology 2002;76(19):9787-97.
2002: Sylvie Beaulieu; Davide F Robbiani; Xixuan Du; Elaine Rodrigues; Ralf Ignatius; Yang Wei; Paul Ponath; James W Young; Melissa Pope; Ralph M Steinman; Svetlana Mojsov
Expression of a functional eotaxin (CC chemokine ligand 11) receptor CCR3 by human dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):2925-36.
2002: Shin-ichiro Fujii; Kanako Shimizu; Mitchell Kronenberg; Ralph M Steinman
Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs.
Nature immunology 2002;3(9):867-74.
2002: Rodica Ciubotariu; Ming L Tsang; Ralph M Steinman; Nicole Suciu-Foca; Christian Münz
Dendritic cells crossprime allo-specific self-restricted CD4(+) T cells after coculture with dead allogeneic cells.
Human immunology 2002;63(7):517-23.
2002: Madhav V Dhodapkar; Ralph M Steinman
Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans.
Blood 2002;100(1):174-7.
2002: Ralph M Steinman; Melissa Pope
Exploiting dendritic cells to improve vaccine efficacy.
The Journal of clinical investigation 2002;109(12):1519-26.
2002: Tomonori Iyoda; Susumu Shimoyama; Kang Liu; Yoshiki Omatsu; Yuji Akiyama; Yasuhiro Maeda; Kazuhiko Takahara; Ralph M Steinman; Kayo Inaba
The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo.
The Journal of experimental medicine 2002;195(10):1289-302.
2002: Kazuhiko Takahara; Yoshiki Omatsu; Yusuke Yashima; Yasuhiro Maeda; Shusaku Tanaka; Tomonori Iyoda; Björn E Clausen; Kazumi Matsubara; John J Letterio; Ralph M Steinman; Yoichi Matsuda; Kayo Inaba; Bjöern Clusen
Identification and expression of mouse Langerin (CD207) in dendritic cells.
International immunology 2002;14(5):433-44.
2002: Guido Ferlazzo; Ming L Tsang; Lorenzo Moretta; Giovanni Melioli; Ralph M Steinman; Christian Münz
Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells.
The Journal of experimental medicine 2002;195(3):343-51.
2002: Christiane Stahl-Hennig; Ralph M Steinman; Peter Ten Haaft; Klaus Uberla; Nicole Stolte; Sem Saeland; Klara Tenner-Racz; Paul Racz
The simian immunodeficiency virus deltaNef vaccine, after application to the tonsils of Rhesus macaques, replicates primarily within CD4(+) T cells and elicits a local perforin-positive CD8(+) T-cell response.
Journal of virology 2002;76(2):688-96.
2001: Ralph M Steinman; M Dhodapkar
Active immunization against cancer with dendritic cells: the near future.
International journal of cancer. Journal international du cancer 2001;94(4):459-73.
2001: Chae Gyu Park; Kazuhiko Takahara; E Umemoto; Yusuke Yashima; Kazumi Matsubara; Yoichi Matsuda; Björn E Clausen; Kayo Inaba; Ralph M Steinman
Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN.
International immunology 2001;13(10):1283-90.
2001: Daniel Hawiger; Kayo Inaba; Yair Dorsett; M Guo; Karsten Mahnke; M Rivera; Jeffrey V Ravetch; Ralph M Steinman; Michel C Nussenzweig
Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo.
The Journal of experimental medicine 2001;194(6):769-79.
2001: J Engelmayer; Marie Larsson; A Lee; M Lee; WI Cox; Ralph M Steinman; Nina Bhardwaj
Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals.
Journal of virology 2001;75(5):2142-53.
2001: Marion Subklewe; Casper Paludan; Ming L Tsang; Karsten Mahnke; Ralph M Steinman; Christian Münz
Dendritic cells cross-present latency gene products from Epstein-Barr virus-transformed B cells and expand tumor-reactive CD8(+) killer T cells.
The Journal of experimental medicine 2001;193(3):405-11.
2001: Madhav V Dhodapkar; Ralph M Steinman; Joseph Krasovsky; C Munz; Nina Bhardwaj
Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells.
The Journal of experimental medicine 2001;193(2):233-8.
2000: Madhav V Dhodapkar; James W Young; Paul B Chapman; W I Cox; Jean-François Fonteneau; S Amigorena; Alan N Houghton; Ralph M Steinman; Nina Bhardwaj
Paucity of functional T-cell memory to melanoma antigens in healthy donors and melanoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(12):4831-8.
2000: Angela Granelli-Piperno; L Zhong; Patrick A J Haslett; J Jacobson; Ralph M Steinman
Dendritic cells, infected with vesicular stomatitis virus-pseudotyped HIV-1, present viral antigens to CD4+ and CD8+ T cells from HIV-1-infected individuals.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6620-6.
2000: Ralf Ignatius; Mary A Marovich; Erin Mehlhop; Loreley A Villamide; Karsten Mahnke; WI Cox; F Isdell; Sarah Schlesinger Frankel; John R Mascola; Ralph M Steinman; Melissa Pope
Canarypox virus-induced maturation of dendritic cells is mediated by apoptotic cell death and tumor necrosis factor alpha secretion.
Journal of virology 2000;74(23):11329-38.
2000: Ralf Ignatius; Karsten Mahnke; M Rivera; K Hong; F Isdell; Ralph M Steinman; Melissa Pope; Leonidas Stamatatos
Presentation of proteins encapsulated in sterically stabilized liposomes by dendritic cells initiates CD8(+) T-cell responses in vivo.
Blood 2000;96(10):3505-13.
2000: L Zhong; Angela Granelli-Piperno; Melissa Pope; Ralf Ignatius; Mark G Lewis; Sarah Schlesinger Frankel; Ralph M Steinman
Presentation of SIVgag to monkey T cells using dendritic cells transfected with a recombinant adenovirus.
European journal of immunology 2000;30(11):3281-90.
2000: Karsten Mahnke; M Guo; S Lee; H Sepulveda; S L Swain; Michel C Nussenzweig; Ralph M Steinman
The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments.
The Journal of cell biology 2000;151(3):673-84.
2000: M Guo; S Gong; S Maric; Ziva Misulovin; Maggi Pack; Karsten Mahnke; Michel C Nussenzweig; Ralph M Steinman
A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells.
Human immunology 2000;61(8):729-38.
2000: Ralf Ignatius; Yang Wei; S Beaulieu; Agegnehu Gettie; Ralph M Steinman; Melissa Pope; Svetlana Mojsov
The immunodeficiency virus coreceptor, Bonzo/STRL33/TYMSTR, is expressed by macaque and human skin- and blood-derived dendritic cells.
AIDS research and human retroviruses 2000;16(11):1055-9.
2000: Christian Münz; Kara Bickham; Marion Subklewe; Ming L Tsang; A Chahroudi; Michael Kurilla; D Zhang; Mike O'Donnell; Ralph M Steinman
Human CD4(+) T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1.
The Journal of experimental medicine 2000;191(10):1649-60.
2000: John A Carucci; Ralf Ignatius; Yang Wei; AM Cypess; D A Schaer; Melissa Pope; Ralph M Steinman; Svetlana Mojsov
Calcitonin gene-related peptide decreases expression of HLA-DR and CD86 by human dendritic cells and dampens dendritic cell-driven T cell-proliferative responses via the type I calcitonin gene-related peptide receptor.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3494-9.
2000: Kayo Inaba; Shannon Turley; Tomonori Iyoda; F Yamaide; Susumu Shimoyama; C Reis e Sousa; R N Germain; Ira Mellman; Ralph M Steinman
The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli.
The Journal of experimental medicine 2000;191(6):927-36.
2000: Ralph M Steinman
DC-SIGN: a guide to some mysteries of dendritic cells.
Cell 2000;100(5):491-4.
2000: Madhav V Dhodapkar; Joseph Krasovsky; Ralph M Steinman; Nina Bhardwaj
Mature dendritic cells boost functionally superior CD8(+) T-cell in humans without foreign helper epitopes.
The Journal of clinical investigation 2000;105(6):R9-R14.
2000: Davorka Messmer; Ralf Ignatius; Christine Santisteban; Ralph M Steinman; Melissa Pope
The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cellsand T cells.
Journal of virology 2000;74(5):2406-13.
2000: Régis Josien; HL Li; E Ingulli; S Sarma; BR Wong; Masha Vologodskaia; Ralph M Steinman; Yongwon Choi
TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivo.
The Journal of experimental medicine 2000;191(3):495-502.
2000: Ralph M Steinman; Shannon Turley; Ira Mellman; Kayo Inaba
The induction of tolerance by dendritic cells that have captured apoptotic cells.
The Journal of experimental medicine 2000;191(3):411-6.
1999: J Engelmayer; Marie Larsson; Marion Subklewe; A Chahroudi; WI Cox; Ralph M Steinman; Nina Bhardwaj
Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6762-8.
1999: Marion Subklewe; A Chahroudi; Kara Bickham; Marie Larsson; Michael Kurilla; Nina Bhardwaj; Ralph M Steinman
Presentation of epstein-barr virus latency antigens to CD8(+), interferon-gamma-secreting, T lymphocytes.
European journal of immunology 1999;29(12):3995-4001.
1999: Christiane Stahl-Hennig; Ralph M Steinman; Klara Tenner-Racz; M Pope; Nicole Stolte; Kerstin Mätz-Rensing; G Grobschupff; B Raschdorff; Gerhard Hunsmann; Paul Racz
Rapid infection of oral mucosal-associated lymphoid tissue with simian immunodeficiency virus.
Science (New York, N.Y.) 1999;285(5431):1261-5.
1999: Marion Subklewe; A Chahroudi; Alan L Schmaljohn; Michael Kurilla; Nina Bhardwaj; Ralph M Steinman
Induction of Epstein-Barr virus-specific cytotoxic T-lymphocyte responses using dendritic cells pulsed with EBNA-3A peptides or UV-inactivated, recombinant EBNA-3A vaccinia virus.
Blood 1999;94(4):1372-81.
1999: Ralph M Steinman; K Inaba
Myeloid dendritic cells.
Journal of leukocyte biology 1999;66(2):205-8.
1999: Ralph M Steinman; K Inaba; Shannon Turley; Philippe Pierre; I Mellman
Antigen capture, processing, and presentation by dendritic cells: recent cell biological studies.
Human immunology 1999;60(7):562-7.
1999: Madhav V Dhodapkar; Ralph M Steinman; M Sapp; H Desai; C Fossella; Joseph Krasovsky; Sean M Donahoe; P R Dunbar; V Cerundolo; Douglas F Nixon; Nina Bhardwaj
Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells.
The Journal of clinical investigation 1999;104(2):173-80.
1999: Marie Larsson; Xia Jin; Bharat Ramratnam; Graham S Ogg; J Engelmayer; MA Demoitie; Andrew J McMichael; WI Cox; Ralph M Steinman; D Nixon; Nina Bhardwaj
A recombinant vaccinia virus based ELISPOT assay detects high frequencies of Pol-specific CD8 T cells in HIV-1-positive individuals.
AIDS (London, England) 1999;13(7):767-77.
1999: Martin F Bachmann; BR Wong; Régis Josien; Ralph M Steinman; A Oxenius; Yongwon Choi
TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation.
The Journal of experimental medicine 1999;189(7):1025-31.
1999: L Zhong; Angela Granelli-Piperno; Y Choi; Ralph M Steinman
Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells.
European journal of immunology 1999;29(3):964-72.
1999: Régis Josien; BR Wong; HL Li; Ralph M Steinman; Yongwon Choi
TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2562-8.
1999: Angela Granelli-Piperno; V Finkel; E Delgado; Ralph M Steinman
Virus replication begins in dendritic cells during the transmission of HIV-1 from mature dendritic cells to T cells.
Current biology : CB 1999;9(1):21-9.
1998: Kayo Inaba; Shannon Turley; F Yamaide; Tomonori Iyoda; Karsten Mahnke; M Inaba; Maggi Pack; Marion Subklewe; B Sauter; David Sheff; M Albert; Nina Bhardwaj; Ira Mellman; Ralph M Steinman
Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells.
The Journal of experimental medicine 1998;188(11):2163-73.
1998: Sarah Schlesinger Frankel; Ralph M Steinman; Nelson L Michael; S R Kim; N Bhardwaj; Melissa Pope; Mark K Louder; Philip K Ehrenberg; P W Parren; D R Burton; H Katinger; Thomas C VanCott; Merlin L Robb; Deborah L Birx; John R Mascola
Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to T cells.
Journal of virology 1998;72(12):9788-94.
1998: BR Wong; Régis Josien; SY Lee; Masha Vologodskaia; Ralph M Steinman; Yongwon Choi
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.
The Journal of biological chemistry 1998;273(43):28355-9.
1998: Angela Granelli-Piperno; E Delgado; V Finkel; William A Paxton; Ralph M Steinman
Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-tropic virus to T cells.
Journal of virology 1998;72(4):2733-7.
1998: Klara Tenner-Racz; Hans-Jürgen Stellbrink; Jan van Lunzen; C Schneider; J P Jacobs; B Raschdorff; Gudrun Grosschupff; Ralph M Steinman; Paul Racz
The unenlarged lymph nodes of HIV-1-infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation. The impact of highly active antiretroviral therapy.
The Journal of experimental medicine 1998;187(6):949-59.
1998: E Delgado; V Finkel; M Baggiolini; CR Mackay; Ralph M Steinman; Angela Granelli-Piperno
Mature dendritic cells respond to SDF-1, but not to several beta-chemokines.
Immunobiology 1998;198(5):490-500.
1998: Mia Talmor; A Mirza; Shannon Turley; I Mellman; Lloyd A Hoffman; Ralph M Steinman
Generation or large numbers of immature and mature dendritic cells from rat bone marrow cultures.
European journal of immunology 1998;28(3):811-7.
1998: Ralph M Steinman; R N Germain
Antigen presentation and related immunological aspects of HIV-1 vaccines.
AIDS (London, England) 1998;12 Suppl A():S97-112.
1997: BR Wong; Régis Josien; SY Lee; B Sauter; HL Li; Ralph M Steinman; Yongwon Choi
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor.
The Journal of experimental medicine 1997;186(12):2075-80.
1997: Sofia Casares; K Inaba; Teodor-D Brumeanu; Ralph M Steinman; Constantin A Bona
Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope.
The Journal of experimental medicine 1997;186(9):1481-6.
1997: Kayo Inaba; Maggi Pack; M Inaba; H Sakuta; F Isdell; Ralph M Steinman
High levels of a major histocompatibility complex II-self peptide complex on dendritic cells from the T cell areas of lymph nodes.
The Journal of experimental medicine 1997;186(5):665-72.
1997: Sarah Schlesinger Frankel; Klara Tenner-Racz; Paul Racz; Bruce Wenig; C H Hansen; Dennis K Heffner; AM Nelson; Melissa Pope; Ralph M Steinman
Active replication of HIV-1 at the lymphoepithelial surface of the tonsil.
The American journal of pathology 1997;151(1):89-96.
1997: Ralph M Steinman; Maggi Pack; Kayo Inaba
Dendritic cells in the T-cell areas of lymphoid organs.
Immunological reviews 1997;156():25-37.
1997: Angela Granelli-Piperno; D Chen; B Moser; Ralph M Steinman
The HIV-1 life cycle is blocked at two different points in mature dendritic cells.
Advances in experimental medicine and biology 1997;417():415-9.
1997: A Bender; M Sapp; M Feldman; A Reddy; R Seder; G Schuler; Ralph M Steinman; N Bhardwaj
Dendritic cells as immunogens for human CTL responses.
Advances in experimental medicine and biology 1997;417():383-7.
1997: Ralph M Steinman; Maggi Pack; Kayo Inaba
Dendritic cell development and maturation.
Advances in experimental medicine and biology 1997;417():1-6.
1996: Angela Granelli-Piperno; B Moser; Melissa Pope; D Chen; Y Wei; F Isdell; Una O'Doherty; William A Paxton; R Koup; S Mojsov; Nina Bhardwaj; I Clark-Lewis; M Baggiolini; Ralph M Steinman
Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors.
The Journal of experimental medicine 1996;184(6):2433-8.
1996: A Bender; M Sapp; Gerold Schuler; Ralph M Steinman; Nina Bhardwaj
Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood.
Journal of immunological methods 1996;196(2):121-35.
1996: Ralph M Steinman
Dendritic cells and immune-based therapies.
Experimental hematology 1996;24(8):859-62.
1996: P Szabolcs; D Avigan; S Gezelter; D H Ciocon; Malcolm A S Moore; Ralph M Steinman; James W Young
Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate.
Blood 1996;87(11):4520-30.
1996: Christine Heufler; Franz Koch; U Stanzl; Gerda Topar; M Wysocka; G Trinchieri; A Enk; Ralph M Steinman; Nikolaus Romani; Gerold Schuler
Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.
European journal of immunology 1996;26(3):659-68.
1996: paul cameron; M Pope; Angela Granelli-Piperno; Ralph M Steinman
Dendritic cells and the replication of HIV-1.
Journal of leukocyte biology 1996;59(2):158-71.
1995: Melissa Pope; S Gezelter; N Gallo; L Hoffman; Ralph M Steinman
Low levels of HIV-1 infection in cutaneous dendritic cells promote extensive viral replication upon binding to memory CD4+ T cells.
The Journal of experimental medicine 1995;182(6):2045-56.
1995: Angela Granelli-Piperno; Melissa Pope; Kayo Inaba; Ralph M Steinman
Coexpression of NF-kappa B/Rel and Sp1 transcription factors in human immunodeficiency virus 1-induced, dendritic cell-T-cell syncytia.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):10944-8.
1995: Mia Talmor; Ralph M Steinman; M A Codner; M Chen; A D Harper; M D Witmer-Pack; Lloyd A Hoffman
Bone marrow-derived chimerism in non-irradiated, cyclosporin-treated rats receiving microvascularized limb transplants: evidence for donor-derived dendritic cells in recipient lymphoid tissues.
Immunology 1995;86(3):448-55.
1995: W J Swiggard; A Mirza; Michel C Nussenzweig; Ralph M Steinman
DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: purification, characterization, and N-terminal amino acid sequence.
Cellular immunology 1995;165(2):302-11.
1995: Ralph M Steinman; Joel A Swanson
The endocytic activity of dendritic cells.
The Journal of experimental medicine 1995;182(2):283-8.
1995: M D Witmer-Pack; W J Swiggard; A Mirza; Kayo Inaba; Ralph M Steinman
Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. II. Expression in situ in lymphoid and nonlymphoid tissues.
Cellular immunology 1995;163(1):157-62.
1995: Kayo Inaba; W J Swiggard; M Inaba; Jed A Meltzer; A Mirza; T Sasagawa; Michel C Nussenzweig; Ralph M Steinman
Tissue distribution of the DEC-205 protein that is detected by the monoclonal antibody NLDC-145. I. Expression on dendritic cells and other subsets of mouse leukocytes.
Cellular immunology 1995;163(1):148-56.
1995: W Jiang; W J Swiggard; Christine Heufler; M Peng; A Mirza; Ralph M Steinman; Michel C Nussenzweig
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing.
Nature 1995;375(6527):151-5.
1995: Y Yamaguchi; Una O'Doherty; M Peng; Ralph M Steinman
Difficulties in obtaining monoclonal antibodies to subsets of human leukocytes, using neonatal tolerance induction in mice.
Journal of immunological methods 1995;181(1):115-24.
1995: Kayo Inaba; M Inaba; M Witmer-Pack; K Hatchcock; R Hodes; Ralph M Steinman
Expression of B7 costimulator molecules on mouse dendritic cells.
Advances in experimental medicine and biology 1995;378():65-70.
1995: Melissa Pope; M G Betjes; Nikolaus Romani; H Hirmand; L Hoffman; S Gezelter; Gerold Schuler; paul cameron; Ralph M Steinman
Dendritic cell-T cell conjugates that migrate from normal human skin are an explosive site of infection for HIV-1.
Advances in experimental medicine and biology 1995;378():457-60.
1995: Nina Bhardwaj; A Bender; N Gonzalez; L K Bui; M C Garrett; Ralph M Steinman
Stimulation of human anti-viral CD8+ cytolytic T lymphocytes by dendritic cells.
Advances in experimental medicine and biology 1995;378():375-9.
1995: Christine Heufler; C Humborg; Ralph M Steinman; Gerold Schuler; Michel C Nussenzweig
A molecular strategy to identify molecules that are specific for dendritic cells and/or critical to their unique immunostimulatory function.
Advances in experimental medicine and biology 1995;378():367-9.
1995: Melissa Pope; M G Betjes; H Hirmand; L Hoffman; Ralph M Steinman
Both dendritic cells and memory T lymphocytes emigrate from organ cultures of human skin and form distinctive dendritic-T-cell conjugates.
The Journal of investigative dermatology 1995;104(1):11-7.
1994: Kayo Inaba; M Witmer-Pack; M Inaba; K S Hathcock; H Sakuta; M Azuma; H Yagita; K Okumura; P S Linsley; S Ikehara; S Muramatsu; Richard J Hodes; Ralph M Steinman
The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.
The Journal of experimental medicine 1994;180(5):1849-60.
1994: paul cameron; M G Lowe; Suzanne M Crowe; Una O'Doherty; M Pope; S Gezelter; Ralph M Steinman
Susceptibility of dendritic cells to HIV-1 infection in vitro.
Journal of leukocyte biology 1994;56(3):257-65.
1994: Melissa Pope; M G Betjes; Nikolaus Romani; H Hirmand; paul cameron; L Hoffman; S Gezelter; Gerold Schuler; Ralph M Steinman
Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1.
Cell 1994;78(3):389-98.
1994: Nina Bhardwaj; A Bender; N Gonzalez; L K Bui; M C Garrett; Ralph M Steinman
Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells.
The Journal of clinical investigation 1994;94(2):797-807.
1994: Nikolaus Romani; S Gruner; D Brang; Eckhart Kämpgen; A Lenz; B Trockenbacher; G Konwalinka; Peter Fritsch; Ralph M Steinman; Gerold Schuler
Proliferating dendritic cell progenitors in human blood.
The Journal of experimental medicine 1994;180(1):83-93.
1994: Una O'Doherty; M Peng; S Gezelter; W J Swiggard; M Betjes; Nina Bhardwaj; Ralph M Steinman
Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature.
Immunology 1994;82(3):487-93.
1994: paul cameron; Melissa Pope; S Gezelter; Ralph M Steinman
Infection and apoptotic cell death of CD4+ T cells during an immune response to HIV-1-pulsed dendritic cells.
AIDS research and human retroviruses 1994;10(1):61-71.
1993: P Pancholi; A Mirza; V Schauf; Ralph M Steinman; Nina Bhardwaj
Presentation of mycobacterial antigens by human dendritic cells: lack of transfer from infected macrophages.
Infection and immunity 1993;61(12):5326-32.
1993: Una O'Doherty; Ralph M Steinman; M Peng; paul cameron; S Gezelter; I Kopeloff; W J Swiggard; Melissa Pope; Nina Bhardwaj
Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium.
The Journal of experimental medicine 1993;178(3):1067-76.
1993: Nina Bhardwaj; James W Young; A J Nisanian; J Baggers; Ralph M Steinman
Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses.
The Journal of experimental medicine 1993;178(2):633-42.
1993: M D Witmer-Pack; M T Crowley; Kayo Inaba; Ralph M Steinman
Macrophages, but not dendritic cells, accumulate colloidal carbon following administration in situ.
Journal of cell science 1993;105 ( Pt 4)():965-73.
1993: Kayo Inaba; M Inaba; M Naito; Ralph M Steinman
Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo.
The Journal of experimental medicine 1993;178(2):479-88.
1993: P Pancholi; A Mirza; Nina Bhardwaj; Ralph M Steinman
Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophages.
Science (New York, N.Y.) 1993;260(5110):984-6.
1993: Kayo Inaba; M Inaba; M Deguchi; K Hagi; R Yasumizu; S Ikehara; S Muramatsu; Ralph M Steinman
Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):3038-42.
1993: M D Witmer-Pack; D A Hughes; Gerold Schuler; L Lawson; A McWilliam; Kayo Inaba; Ralph M Steinman; S Gordon
Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse.
Journal of cell science 1993;104 ( Pt 4)():1021-9.
1993: Una O'Doherty; W J Swiggard; Kayo Inaba; Y Yamaguchi; I Kopeloff; Nina Bhardwaj; Ralph M Steinman
Tolerizing mice to human leukocytes: a step toward the production of monoclonal antibodies specific for human dendritic cells.
Advances in experimental medicine and biology 1993;329():165-72.
1993: Ralph M Steinman; M Witmer-Pack; Kayo Inaba
Dendritic cells: antigen presentation, accessory function and clinical relevance.
Advances in experimental medicine and biology 1993;329():1-9.
1992: Kayo Inaba; M Inaba; Nikolaus Romani; H Aya; M Deguchi; S Ikehara; S Muramatsu; Ralph M Steinman
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
The Journal of experimental medicine 1992;176(6):1693-702.
1992: Lloyd A Hoffman; M A Codner; B A Shuster; N Bogossian; L Egozi; A D Harper; Ralph M Steinman; G S LaTrenta; G T Shires
Donor leukocyte migration following extremity transplantation in an experimental model.
Plastic and reconstructive surgery 1992;90(6):999-1006; discussion 1007-8.
1992: R Nonacs; C Humborg; James P Tam; Ralph M Steinman
Mechanisms of mouse spleen dendritic cell function in the generation of influenza-specific, cytolytic T lymphocytes.
The Journal of experimental medicine 1992;176(2):519-29.
1992: paul cameron; P S Freudenthal; J M Barker; S Gezelter; Kayo Inaba; Ralph M Steinman
Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells.
Science (New York, N.Y.) 1992;257(5068):383-7.
1992: J E Ming; Ralph M Steinman; Angela Granelli-Piperno
IL-6 enhances the generation of cytolytic T lymphocytes in the allogeneic mixed leucocyte reaction.
Clinical and experimental immunology 1992;89(1):148-53.
1992: R Agger; M Witmer-Pack; Nikolaus Romani; H Stossel; W J Swiggard; J P Metlay; E Storozynsky; P Freimuth; Ralph M Steinman
Two populations of splenic dendritic cells detected with M342, a new monoclonal to an intracellular antigen of interdigitating dendritic cells and some B lymphocytes.
Journal of leukocyte biology 1992;52(1):34-42.
1992: James W Young; L Koulova; S A Soergel; E A Clark; Ralph M Steinman; Bo Dupont
The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.
The Journal of clinical investigation 1992;90(1):229-37.
1992: P Pancholi; Ralph M Steinman; Nina Bhardwaj
Dendritic cells efficiently immunoselect mycobacterial-reactive T cells in human blood, including clonable antigen-reactive precursors.
Immunology 1992;76(2):217-24.
1992: Kayo Inaba; Ralph M Steinman; Maggi Pack; H Aya; M Inaba; T Sudo; S Wolpe; Gerold Schuler
Identification of proliferating dendritic cell precursors in mouse blood.
The Journal of experimental medicine 1992;175(5):1157-67.
1992: paul cameron; U Forsum; H Teppler; Angela Granelli-Piperno; Ralph M Steinman
During HIV-1 infection most blood dendritic cells are not productively infected and can induce allogeneic CD4+ T cells clonal expansion.
Clinical and experimental immunology 1992;88(2):226-36.
1991: P Pancholi; Ralph M Steinman; Nina Bhardwaj
An approach to isolating T cell lines that react to antigens presented on the surface of dendritic cells.
Clinical and experimental immunology 1991;85(2):349-56.
1991: Ralph M Steinman; James W Young
Signals arising from antigen-presenting cells.
Current opinion in immunology 1991;3(3):361-72.
1991: M J McElrath; Ralph M Steinman; Z A Cohn
Latent HIV-1 infection in enriched populations of blood monocytes and T cells from seropositive patients.
The Journal of clinical investigation 1991;87(1):27-30.
1990: Angela Granelli-Piperno; P Nolan; Kayo Inaba; Ralph M Steinman
The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter.
The Journal of experimental medicine 1990;172(6):1869-72.
1990: M A Codner; B A Shuster; Ralph M Steinman; A D Harper; G S LaTrenta; Lloyd A Hoffman
Migration of donor leukocytes from limb allografts into host lymphoid tissues.
Annals of plastic surgery 1990;25(5):353-9.
1990: Ellen Puré; Kayo Inaba; M T Crowley; L Tardelli; M D Witmer-Pack; G Ruberti; G Fathman; Ralph M Steinman
Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.
The Journal of experimental medicine 1990;172(5):1459-69.
1990: M T Crowley; Kayo Inaba; M D Witmer-Pack; S Gezelter; Ralph M Steinman
Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen.
Journal of immunological methods 1990;133(1):55-66.
1990: P S Freudenthal; Ralph M Steinman
The distinct surface of human blood dendritic cells, as observed after an improved isolation method.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7698-702.
1990: P Freimuth; Ralph M Steinman
Insertion of myoglobin T-cell epitopes into the Escherichia coli alkaline phosphatase.
Research in microbiology 1990;141(7-8):995-1001.
1990: Kayo Inaba; J P Metlay; M T Crowley; Ralph M Steinman
Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.
The Journal of experimental medicine 1990;172(2):631-40.
1990: M Crowley; Kayo Inaba; Ralph M Steinman
Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins.
The Journal of experimental medicine 1990;172(1):383-6.
1990: J P Metlay; M D Witmer-Pack; R Agger; M T Crowley; D Lawless; Ralph M Steinman
The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.
The Journal of experimental medicine 1990;171(5):1753-71.
1990: James W Young; Ralph M Steinman
Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.
The Journal of experimental medicine 1990;171(4):1315-32.
1990: Kayo Inaba; J P Metlay; M T Crowley; M Witmer-Pack; Ralph M Steinman
Dendritic cells as antigen presenting cells in vivo.
International reviews of immunology 1990;6(2-3):197-206.
1989: Ralph M Steinman
Dendritic cells: clinical aspects.
Research in immunology 1989;140(9):911-8; discussion 918-26.
1989: E Langhoff; J McElrath; H J Bos; J Pruett; Angela Granelli-Piperno; Z A Cohn; Ralph M Steinman
Most CD4+ T cells from human immunodeficiency virus-1 infected patients can undergo prolonged clonal expansion.
The Journal of clinical investigation 1989;84(5):1637-43.
1989: Nina Bhardwaj; U Santhanam; L L Lau; S B Tatter; J Ghrayeb; M Rivelis; Ralph M Steinman; Pravin B Sehgal; L T May
IL-6/IFN-beta 2 in synovial effusions of patients with rheumatoid arthritis and other arthritides. Identification of several isoforms and studies of cellular sources.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(7):2153-9.
1989: Kayo Inaba; Nikolaus Romani; Ralph M Steinman
An antigen-independent contact mechanism as an early step in T cell-proliferative responses to dendritic cells.
The Journal of experimental medicine 1989;170(2):527-42.
1989: Angela Granelli-Piperno; M Keane; Ralph M Steinman
Growth factor production and requirements during the proliferative response of human T lymphocytes to anti-CD3 monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4138-43.
1989: Nikolaus Romani; S Koide; M Crowley; M Witmer-Pack; A M Livingstone; C G Fathman; Kayo Inaba; Ralph M Steinman
Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.
The Journal of experimental medicine 1989;169(3):1169-78.
1989: Nikolaus Romani; Kayo Inaba; Ellen Puré; M Crowley; M Witmer-Pack; Ralph M Steinman
A small number of anti-CD3 molecules on dendritic cells stimulate DNA synthesis in mouse T lymphocytes.
The Journal of experimental medicine 1989;169(3):1153-68.
1989: Nina Bhardwaj; L L Lau; S M Friedman; Mary Crow; Ralph M Steinman
Interleukin 1 production during accessory cell-dependent mitogenesis of T lymphocytes.
The Journal of experimental medicine 1989;169(3):1121-36.
1989: M Crowley; Kayo Inaba; M Witmer-Pack; Ralph M Steinman
The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus.
Cellular immunology 1989;118(1):108-25.
1989: J E Ming; C Cernetti; Ralph M Steinman; Angela Granelli-Piperno
Development of cytolytic T lymphocytes in thymus culture requires a cytokine sharing homology with IL-6 alpha.
Annals of the New York Academy of Sciences 1989;557():396-403; discussion 403-4.
1989: J E Ming; C Cernetti; Ralph M Steinman; Angela Granelli-Piperno
Interleukin 6 is the principal cytolytic T lymphocyte differentiation factor for thymocytes in human leukocyte conditioned medium.
The Journal of molecular and cellular immunology : JMCI 1989;4(4):203-11; discussion 211-2.
1989: E Langhoff; Ralph M Steinman
Clonal expansion of human T lymphocytes initiated by dendritic cells.
The Journal of experimental medicine 1989;169(1):315-20.
1989: J P Metlay; Ellen Puré; Ralph M Steinman
Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction.
The Journal of experimental medicine 1989;169(1):239-54.
1989: J P Metlay; Ellen Puré; Ralph M Steinman
Control of the immune response at the level of antigen-presenting cells: a comparison of the function of dendritic cells and B lymphocytes.
Advances in immunology 1989;47():45-116.
1988: Asma Nusrat; Samuel D Wright; Alan Aderem; Ralph M Steinman; Z A Cohn
Properties of isolated red pulp macrophages from mouse spleen.
The Journal of experimental medicine 1988;168(4):1505-10.
1988: Nina Bhardwaj; L L Lau; M Rivelis; Ralph M Steinman
Interleukin-1 production by mononuclear cells from rheumatoid synovial effusions.
Cellular immunology 1988;114(2):405-23.
1988: S Koide; Ralph M Steinman
Induction of interleukin 1 alpha mRNA during the antigen-dependent interaction of sensitized T lymphoblasts with macrophages.
The Journal of experimental medicine 1988;168(1):409-16.
1988: J M Austyn; David E Weinstein; Ralph M Steinman
Clustering with dendritic cells precedes and is essential for T-cell proliferation in a mitogenesis model.
Immunology 1988;63(4):691-6.
1988: Ralph M Steinman
Cytokines amplify the function of accessory cells.
Immunology letters 1988;17(3):197-202.
1988: M D Witmer-Pack; J Valinsky; W Olivier; Ralph M Steinman
Quantitation of surface antigens on cultured murine epidermal Langerhans cells: rapid and selective increase in the level of surface MHC products.
The Journal of investigative dermatology 1988;90(3):387-94.
1988: C Cernetti; Ralph M Steinman; Angela Granelli-Piperno
Identification of a 24-kDa cytokine that is required for development of cytolytic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(5):1605-9.
1988: Kayo Inaba; M D Witmer-Pack; M Inaba; S Muramatsu; Ralph M Steinman
The function of Ia+ dendritic cells and Ia- dendritic cell precursors in thymocyte mitogenesis to lectin and lectin plus interleukin 1.
The Journal of experimental medicine 1988;167(1):149-62.
1988: Ralph M Steinman; Kayo Inaba
The binding of antigen presenting cells to T lymphocytes.
Advances in experimental medicine and biology 1988;237():31-41.
1988: Ralph M Steinman; S Koide; M Witmer; M Crowley; N Bhardwaj; P Freudenthal; James W Young; Kayo Inaba
The sensitization phase of T-cell-mediated immunity.
Annals of the New York Academy of Sciences 1988;546():80-90.
1988: E R Flechner; P S Freudenthal; Gilla Kaplan; Ralph M Steinman
Antigen-specific T lymphocytes efficiently cluster with dendritic cells in the human primary mixed-leukocyte reaction.
Cellular immunology 1988;111(1):183-95.
1988: James W Young; Ralph M Steinman
Accessory cell requirements for the mixed-leukocyte reaction and polyclonal mitogens, as studied with a new technique for enriching blood dendritic cells.
Cellular immunology 1988;111(1):167-82.
1988: M L Birkeland; J Metlay; Virginia M Sanders; R Fernandez-Botran; Ellen S Vitetta; Ralph M Steinman; Ellen Puré
Epitopes on CD45R [T200] molecules define differentiation antigens on murine B and T lymphocytes.
The Journal of molecular and cellular immunology : JMCI 1988;4(2):71-85.
1987: M D Witmer-Pack; W Olivier; J Valinsky; Gerold Schuler; Ralph M Steinman
Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells.
The Journal of experimental medicine 1987;166(5):1484-98.
1987: C Cernetti; Ralph M Steinman; Angela Granelli-Piperno
Bioassays for the detection of a cytokine that enhances the development of cytolytic T lymphocytes.
Cellular immunology 1987;109(1):148-58.
1986: C F Nathan; Gilla Kaplan; W R Levis; A Nusrat; M D Witmer; S A Sherwin; C K Job; C R Horowitz; Ralph M Steinman; Z A Cohn
Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy.
The New England journal of medicine 1986;315(1):6-15.
1986: Gilla Kaplan; M D Witmer; I Nath; Ralph M Steinman; S Laal; Hanumanthappa K Prasad; E N Sarno; U Elvers; Z A Cohn
Influence of delayed immune reactions on human epidermal keratinocytes.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(10):3469-73.
1985: N J Zvaifler; Ralph M Steinman; G Kaplan; L L Lau; M Rivelis
Identification of immunostimulatory dendritic cells in the synovial effusions of patients with rheumatoid arthritis.
The Journal of clinical investigation 1985;76(2):789-800.
1983: J M Austyn; Ralph M Steinman; David E Weinstein; A Granelli-Piperno; M A Palladino
Dendritic cells initiate a two-stage mechanism for T lymphocyte proliferation.
The Journal of experimental medicine 1983;157(4):1101-15.
1983: Ralph M Steinman; B Gutchinov; M D Witmer; M C Nussenzweig
Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice.
The Journal of experimental medicine 1983;157(2):613-27.
1982: M C Nussenzweig; Ralph M Steinman; M D Witmer; B Gutchinov
A monoclonal antibody specific for mouse dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(1):161-5.
1981: M C Nussenzweig; Ralph M Steinman; J C Unkeless; M D Witmer; B Gutchinov; Z A Cohn
Studies of the cell surface of mouse dendritic cells and other leukocytes.
The Journal of experimental medicine 1981;154(1):168-87.
1980: M C Nussenzweig; Ralph M Steinman; B Gutchinov; Z A Cohn
Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes.
The Journal of experimental medicine 1980;152(4):1070-84.
1980: Ralph M Steinman; M D Witmer; M C Nussenzweig; L L Chen; S Schlesinger; Z A Cohn
Dendritic cells of the mouse: identification and characterization.
The Journal of investigative dermatology 1980;75(1):14-6.