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Kurt Stenmark

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R Dale Brown; Joseph T Crossno; Timothy P Garrington; Lauren N Henry; Min Li; Carlin S Long; S Kelly Ambler; Timothy M Sullivan; Kurt R Stenmark
MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension.
Todd M Bull; Kurt R Stenmark
Mechanics and mechanisms of pulmonary hypertension: An introduction to the 55(th) annual Thomas L. Petty Aspen Lung Conference.
Nagavedi Siddaramappa Umapathy; Kurt R Stenmark; Alexander D Verin; Nana Burns; Nooreen Fatteh; Elzbieta Kaczmarek; Rudolf Lucas; Evgenia Gerasimovskaya
Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via Gi and Akt-Dependent Actin Cytoskeleton Remodeling.

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2013: R Dale Brown; Joseph T Crossno; Timothy P Garrington; Lauren N Henry; Min Li; Carlin S Long; S Kelly Ambler; Timothy M Sullivan; Kurt R Stenmark
MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension.
American journal of physiology. Heart and circulatory physiology 2013;304(2):H269-81.
2013: Todd M Bull; Kurt R Stenmark
Mechanics and mechanisms of pulmonary hypertension: An introduction to the 55(th) annual Thomas L. Petty Aspen Lung Conference.
Pulmonary circulation 2013;3(1):127.
2013: Nagavedi Siddaramappa Umapathy; Kurt R Stenmark; Alexander D Verin; Nana Burns; Nooreen Fatteh; Elzbieta Kaczmarek; Rudolf Lucas; Evgenia Gerasimovskaya
Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via Gi and Akt-Dependent Actin Cytoskeleton Remodeling.
PloS one 2013;8(4):e59733.
2013: Maria A Nagel; Kurt R Stenmark; Igor Traktinskiy; Alexander Choe; Maria G Frid; Don Gilden
Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteries.
Neurology 2013;80(1):62-8.
2013: Kurt R Stenmark; Michael E Yeager; Karim C El Kasmi; Evgenia Gerasimovskaya; Min Li; Eva Nozik-Grayck; Suzette R Riddle; Maria G Frid
The adventitia: essential regulator of vascular wall structure and function.
Annual review of physiology 2013;75():23-47.
2013: Devon Scott; Robin Shandas; Kurt R Stenmark; Yan Tan; Wei Tan
High pulsatility flow stimulates smooth muscle cell hypertrophy and contractile protein expression.
American journal of physiology. Lung cellular and molecular physiology 2013;304(1):L70-81.
2012: Eric T Clambey; Sean P Colgan; Edwin F de Zoeten; Louise E Glover; Paul Jedlicka; Eóin N McNamee; Kurt R Stenmark; Joseph A Westrich; John C Cambier; Eric L Campbell; Holger K Eltzschig
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(41):E2784-93.
2012: Paul W Buehler; Ian Connor; Jin Hyen Baek; Joe Bonaventura; Douglas Kominsky; Christina Lisk; Susan M Majka; Eva Nozik-Grayck; Kurt R Stenmark; Tim Sullivan; David C Irwin
Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.
American journal of physiology. Lung cellular and molecular physiology 2012;303(4):L312-26.
2012: Adil Anwar; Mehdi A Fini; Maria G Frid; Evgenia Gerasimovskaya; Binod Kumar; Min Li; B Alexandre McKeon; Barbara O Meyrick; Suzette R Riddle; Roopa Thukaram; Kurt R Stenmark
Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2012;303(1):L1-L11.
2012: Lian Tian; Joseph A Albietz; Philip H Kao; Steven R Lammers; H Jerry Qi; Robin Shandas; Kurt R Stenmark; Kendall S Hunter
Impact of residual stretch and remodeling on collagen engagement in healthy and pulmonary hypertensive calf pulmonary arteries at physiological pressures.
Annals of biomedical engineering 2012;40(7):1419-33.
2012: Michael E Yeager; Kurt R Stenmark; Kelley Colvin; Allen Everett; D Dunbar Ivy
Plasma proteomics of differential outcome to long-term therapy in children with idiopathic pulmonary arterial hypertension.
Proteomics. Clinical applications 2012;6(5-6):257-67.
2012: Mark Reusser; Kendall S Hunter; Steven R Lammers; Kurt R Stenmark
Validation of a pressure diameter method for determining modulus and strain of collagen engagement for long branches of bovine pulmonary arteries.
Journal of biomechanical engineering 2012;134(5):054501.
2012: Michael E Yeager; Kelley Colvin; D Dunbar Ivy; Cecilia M Nguyen; Monica B Reddy; Kurt R Stenmark
Activation of the unfolded protein response is associated with pulmonary hypertension.
Pulmonary circulation 2012;2(2):229-40.
2012: Michael E Yeager; Shinichi Takatsuki; Dmitry D Belchenko; Kelley Colvin; D Dunbar Ivy; Cecilia M Nguyen; Kurt R Stenmark
Circulating myeloid-derived suppressor cells are increased and activated in pulmonary hypertension.
Chest 2012;141(4):944-52.
2012: Maria A Cavasin; Kim Demos-Davies; Julie Harral; Todd R Horn; David C Irwin; Douglas D Lemon; Min Li; Raphael A Nemenoff; Kurt R Stenmark; Lori A Walker; Peter A Watson; Mary C M Weiser-Evans; Michael E Yeager; Adil Anwar; Nicholas Birdsey; Peter M Buttrick; Timothy A McKinsey
Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism.
Circulation research 2012;110(5):739-48.
2012: Kurt R Stenmark; Michael Yeager; Maria G Frid; Min Li; Timothy McKinsey; Suzette R Riddle; Karim C El Kasmi
Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change.
Pulmonary circulation 2012;2(1):3-14.
2011: Lian Tian; Kurt R Stenmark; Kendall S Hunter; Philip H Kao; Steven R Lammers; H Jerry Qi; Mark Reusser; Robin Shandas
Linked opening angle and histological and mechanical aspects of the proximal pulmonary arteries of healthy and pulmonary hypertensive rats and calves.
American journal of physiology. Heart and circulatory physiology 2011;301(5):H1810-8.
2011: Min Li; B Alexandre McKeon; Timothy A McKinsey; Barbara Meyrick; Suzette R Riddle; Ronald J Sokol; Adil Anwar; Carlos Barajas; Karim C El Kasmi; Amanda R Flockton; Maria G Frid; Todd R Horn; Douglas D Lemon; Derek Strassheim; Michael E Yeager; Kurt R Stenmark
Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2711-22.
2011: Lori A Walker; Dale R Brown; Amelia Glazier; Kurt R Stenmark; John S Walker; Peter M Buttrick
Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension.
American journal of physiology. Heart and circulatory physiology 2011;301(3):H832-40.
2011: Maria A Nagel; A Russman; Kurt R Stenmark; I Traktinskiy; E M VanEgmond; Mary Wellish; Y Azarkh; A Choe; randall cohrs; R Cordery-Cotter; Maria G Frid; T Hedley-Whyte; Bette K Kleinschmidt-DeMasters; Ravi Mahalingam; D Gilden
Varicella zoster virus vasculopathy: analysis of virus-infected arteries.
Neurology 2011;77(4):364-70.
2011: Susan M Majka; Ellen Burnham; Kurt R Stenmark
Cell-based therapies in pulmonary hypertension: who, what, and when?
American journal of physiology. Lung cellular and molecular physiology 2011;301(1):L9-L11.
2011: Zachary Van Rheen; Cheryl Fattman; Shannon Domarski; Susan M Majka; Dwight J Klemm; Kurt R Stenmark; Eva Nozik-Grayck
Lung extracellular superoxide dismutase overexpression lessens bleomycin-induced pulmonary hypertension and vascular remodeling.
American journal of respiratory cell and molecular biology 2011;44(4):500-8.
2011: Taras Lyubchenko; Heather Woodward; Kristopher D Veo; Nana Burns; Hala Nijmeh; Ganna A Liubchenko; Kurt R Stenmark; Evgenia Gerasimovskaya
P2Y1 and P2Y13 purinergic receptors mediate Ca2+ signaling and proliferative responses in pulmonary artery vasa vasorum endothelial cells.
American journal of physiology. Cell physiology 2011;300(2):C266-75.
2011: Tanya Hartney; Maylyn Martinez; Rahul Birari; Stephen Matthew Black; Kurt R Stenmark; Sujatha Venkataraman; Leah Villegas; Eva Nozik-Grayck
Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.
PloS one 2011;6(11):e27531.
2011: Michael E Yeager; Maria G Frid; Kurt R Stenmark
Progenitor cells in pulmonary vascular remodeling.
Pulmonary circulation 2011;1(1):3-16.
2011: Susan Majka; Eva Nozik-Grayck; Helene Paradis; Kurt R Stenmark; Thomas Blackwell; Daniel Crona; Robert Gendron; Moira Hagen; Julie Harral; Jennifer A Johnson; James E Loyd; James West
Physiologic and molecular consequences of endothelial Bmpr2 mutation.
Respiratory research 2011;12():84.
2011: Mark Roedersheimer; Hala Nijmeh; Nana Burns; Asya A Sidiakova; Kurt R Stenmark; Evgenia Gerasimovskaya
Complementary effects of extracellular nucleotides and platelet-derived extracts on angiogenesis of vasa vasorum endothelial cells in vitro and subcutaneous Matrigel plugs in vivo.
Vascular cell 2011;3(1):4.
2010: Margaret B Clarke; Rachel Wright; David Irwin; Swapan Bose; Zachary Van Rheen; Rahul Birari; Kurt R Stenmark; Joe M McCord; Eva Nozik-Grayck
Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration.
Free radical biology & medicine 2010;49(12):2032-9.
2010: Kendall S Hunter; Joseph A Albietz; Po-Feng Lee; Craig Lanning; Steven R Lammers; Stephen H Hofmeister; Philip H Kao; H Jerry Qi; Kurt R Stenmark; Robin Shandas
In vivo measurement of proximal pulmonary artery elastic modulus in the neonatal calf model of pulmonary hypertension: development and ex vivo validation.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;108(4):968-75.
2010: Kurt R Stenmark; Marlene Rabinovitch
Emerging therapies for the treatment of pulmonary hypertension.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2010;11(2 Suppl):S85-90.
2009: Derek Strassheim; Suzzette R Riddle; Danielle L Burke; Mark W Geraci; Kurt R Stenmark
Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):6981-8.
2009: Maria G Frid; Min Li; Meena Gnanasekharan; Danielle L Burke; Miguel Fragoso; Derek Strassheim; Joanna L Sylman; Kurt R Stenmark
Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall.
American journal of physiology. Lung cellular and molecular physiology 2009;297(6):L1059-72.
2009: Heather N Woodward; Adil Anwar; Suzette Riddle; Laimute Taraseviciene-Stewart; Miguel Fragoso; Kurt R Stenmark; Evgenia Gerasimovskaya
PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2009;297(5):L954-64.
2009: Danielle L Burke; Maria G Frid; Claudia L Kunrath; Vijaya Karoor; Adil Anwar; Brandie D Wagner; Derek Strassheim; Kurt R Stenmark
Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment.
American journal of physiology. Lung cellular and molecular physiology 2009;297(2):L238-50.
2009: Min Li; Devon E Scott; Robin Shandas; Kurt R Stenmark; Wei Tan
High pulsatility flow induces adhesion molecule and cytokine mRNA expression in distal pulmonary artery endothelial cells.
Annals of biomedical engineering 2009;37(6):1082-92.
2009: Min Li; Kurt R Stenmark; Robin Shandas; Wei Tan
Effects of pathological flow on pulmonary artery endothelial production of vasoactive mediators and growth factors.
Journal of vascular research 2009;46(6):561-71.
2008: Susan M Majka; M Skokan; L Wheeler; Julie Harral; S Gladson; E Burnham; James E Loyd; Kurt R Stenmark; Marileila Varella-Garcia; James West
Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension.
American journal of physiology. Lung cellular and molecular physiology 2008;295(6):L1028-39.
2008: Eva Nozik-Grayck; Hagir Suliman; Susan Majka; Joseph Albietz; Zachary Van Rheen; Kevin Roush; Kurt R Stenmark
Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling.
American journal of physiology. Lung cellular and molecular physiology 2008;295(3):L422-30.
2008: Mita Das; Nana Burns; Shelly J Wilson; W Michael Zawada; Kurt R Stenmark
Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia.
Cardiovascular research 2008;78(3):440-8.
2008: Evgenia Gerasimovskaya; Heather N Woodward; Doug A Tucker; Kurt R Stenmark
Extracellular ATP is a pro-angiogenic factor for pulmonary artery vasa vasorum endothelial cells.
Angiogenesis 2008;11(2):169-82.
2007: Enrique Arciniegas; Maria G Frid; Ivor S Douglas; Kurt R Stenmark
Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology 2007;293(1):L1-8.
2007: Joseph T Crossno; Chrystelle Garat; Jane E B Reusch; Kenneth G Morris; Edward C Dempsey; Ivan F McMurtry; Kurt R Stenmark; Dwight J Klemm
Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling.
American journal of physiology. Lung cellular and molecular physiology 2007;292(4):L885-97.
2007: Eva Nozik-Grayck; Kurt R Stenmark
Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling.
Advances in experimental medicine and biology 2007;618():101-12.
2006: Kurt R Stenmark; Karen A Fagan; Maria G Frid
Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms.
Circulation research 2006;99(7):675-91.
2006: Neil J Davie; Evgenia Gerasimovskaya; Stephen E Hofmeister; Aaron P Richman; Peter Lloyd Jones; John T Reeves; Kurt R Stenmark
Pulmonary artery adventitial fibroblasts cooperate with vasa vasorum endothelial cells to regulate vasa vasorum neovascularization: a process mediated by hypoxia and endothelin-1.
The American journal of pathology 2006;168(6):1793-807.
2006: Kurt R Stenmark; Neil J Davie; Maria G Frid; Evgenia Gerasimovskaya; Mita Das
Role of the adventitia in pulmonary vascular remodeling.
Physiology (Bethesda, Md.) 2006;21():134-45.
2006: Megan D Short; Stephanie M Fox; Ching F Lam; Kurt R Stenmark; Mita Das
Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression.
Molecular biology of the cell 2006;17(4):1995-2008.
2006: Janet M Wenzlau; Pamela J Garl; Peter Simpson; Kurt R Stenmark; James West; Kristin Bruk Artinger; Raphael A Nemenoff; Mary C M Weiser-Evans
Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development.
Circulation research 2006;98(6):846-55.
2006: Maria G Frid; Jacqueline A Brunetti; Danielle L Burke; Todd C Carpenter; Neil J Davie; John T Reeves; Mark T Roedersheimer; Nico van Rooijen; Kurt R Stenmark
Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage.
The American journal of pathology 2006;168(2):659-69.
2005: Evgenia Gerasimovskaya; Neil J Davie; Shama Ahmad; Doug A Tucker; Carl W White; Kurt R Stenmark
Extracellular adenosine triphosphate: a potential regulator of vasa vasorum neovascularization in hypoxia-induced pulmonary vascular remodeling.
Chest 2005;128(6 Suppl):608S-610S.
2005: Maria G Frid; Jacqueline A Brunetti; Danielle L Burke; Todd C Carpenter; Neil J Davie; Kurt R Stenmark
Circulating mononuclear cells with a dual, macrophage-fibroblast phenotype contribute robustly to hypoxia-induced pulmonary adventitial remodeling.
Chest 2005;128(6 Suppl):583S-584S.
2005: Megan Short; Stephanie Fox; Kurt R Stenmark; Mita Das
Hypoxia-induced alterations in protein kinase C zeta signaling result in augmented fibroblast proliferation.
Chest 2005;128(6 Suppl):582S.
2005: Todd C Carpenter; Stacey Schomberg; Kurt R Stenmark
Endothelin-mediated increases in lung VEGF content promote vascular leak in young rats exposed to viral infection and hypoxia.
American journal of physiology. Lung cellular and molecular physiology 2005;289(6):L1075-82.
2005: Michael R Narkewicz; Arvind Kasaragod; M Scott Lucia; Sean Pflummer; Ronald Sokol; Kurt R Stenmark
Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresia.
Journal of pediatric surgery 2005;40(11):1721-5.
2005: John T Reeves; John H Linehan; Kurt R Stenmark
Distensibility of the normal human lung circulation during exercise.
American journal of physiology. Lung cellular and molecular physiology 2005;288(3):L419-25.
2005: Kurt R Stenmark; Neil J Davie; John T Reeves; Maria G Frid
Hypoxia, leukocytes, and the pulmonary circulation.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(2):715-21.
2005: Evgenia Gerasimovskaya; Doug A Tucker; Kurt R Stenmark
Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(2):722-31.
2005: Mark F Banks; Evgenia Gerasimovskaya; Doug A Tucker; Maria G Frid; Todd C Carpenter; Kurt R Stenmark
Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(2):732-8.
2005: Evgenia Gerasimovskaya; Doug A Tucker; Mary C M Weiser-Evans; Janet M Wenzlau; Dwight J Klemm; Mark Banks; Kurt R Stenmark
Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of rapamycin, and p70 S6 kinase signaling pathways.
The Journal of biological chemistry 2005;280(3):1838-48.
2005: Kurt R Stenmark; Steven H Abman
Lung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia.
Annual review of physiology 2005;67():623-61.
2004: Lynne Bemis; Denise A Chan; Carla V Finkielstein; Lin Qi; Patrick D Sutphin; Xiaojiang S Chen; Kurt R Stenmark; Amato J Giaccia; Wayne Zundel
Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5.
Genes & development 2004;18(7):739-44.
2004: Neil J Davie; Joseph T Crossno; Maria G Frid; Stephen E Hofmeister; John T Reeves; Dallas M Hyde; Todd C Carpenter; Jacqueline A Brunetti; Ian K McNiece; Kurt R Stenmark
Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells.
American journal of physiology. Lung cellular and molecular physiology 2004;286(4):L668-78.
2004: Peter M Mourani; Pamela J Garl; Janet M Wenzlau; Todd C Carpenter; Kurt R Stenmark; Mary C M Weiser-Evans
Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN.
Circulation 2004;109(10):1299-306.
2004: Megan Short; Raphael A Nemenoff; W Michael Zawada; Kurt R Stenmark; Mita Das
Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts.
American journal of physiology. Cell physiology 2004;286(2):C416-25.
2004: Maria G Frid; Almaz A Aldashev; Joseph T Crossno; Jennifer M Jorgensen; Vishakha A Kale; Kurt R Stenmark
Yin and Yang of an endothelial cell: from normal to the extreme in growth, secretion, and transdifferentiation capabilities.
Paediatric respiratory reviews 2004;5 Suppl A():S253-7.
2004: Todd C Carpenter; Kurt R Stenmark
Predisposition of infants with chronic lung disease to respiratory syncytial virus-induced respiratory failure: a vascular hypothesis.
The Pediatric infectious disease journal 2004;23(1 Suppl):S33-40.
2003: Leopold Stiebellehner; Maria G Frid; John T Reeves; Robert B Low; Meena Gnanasekharan; Kurt R Stenmark
Bovine distal pulmonary arterial media is composed of a uniform population of well-differentiated smooth muscle cells with low proliferative capabilities.
American journal of physiology. Lung cellular and molecular physiology 2003;285(4):L819-28.
2003: Todd Carpenter; Stacey Schomberg; Wolfgang Steudel; John Ozimek; Kelley Colvin; Kurt R Stenmark; D Dunbar Ivy
Endothelin B receptor deficiency predisposes to pulmonary edema formation via increased lung vascular endothelial cell growth factor expression.
Circulation research 2003;93(5):456-63.
2003: Heather A Walker; John Michael Whitelock; Pamela J Garl; Raphael A Nemenoff; Kurt R Stenmark; Mary C M Weiser-Evans
Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling.
Molecular biology of the cell 2003;14(5):1941-52.
2003: Jenny Tock; Vicki Van Putten; Kurt R Stenmark; Raphael A Nemenoff
Induction of SM-alpha-actin expression by mechanical strain in adult vascular smooth muscle cells is mediated through activation of JNK and p38 MAP kinase.
Biochemical and biophysical research communications 2003;301(4):1116-21.
2003: Shama Ahmad; Aftab Ahmad; Evgenia Gerasimovskaya; Kurt R Stenmark; Corrie B Allen; Carl W White
Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of phosphatidylinositol 3-kinase.
American journal of respiratory cell and molecular biology 2003;28(2):179-87.
2003: Kurt R Stenmark; Sarah A Gebb
Lung vascular development: breathing new life into an old problem.
American journal of respiratory cell and molecular biology 2003;28(2):133-7.
2003: Todd C Carpenter; Stacey Schomberg; Christopher Nichols; Kurt R Stenmark; John V Weil
Hypoxia reversibly inhibits epithelial sodium transport but does not inhibit lung ENaC or Na-K-ATPase expression.
American journal of physiology. Lung cellular and molecular physiology 2003;284(1):L77-83.
2002: Kurt R Stenmark; Evgenia Gerasimovskaya; Raphael A Nemenoff; Mita Das
Hypoxic activation of adventitial fibroblasts: role in vascular remodeling.
Chest 2002;122(6 Suppl):326S-334S.
2002: Evgenia Gerasimovskaya; Shama Ahmad; Carl W White; Peter Lloyd Jones; Todd C Carpenter; Kurt R Stenmark
Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor.
The Journal of biological chemistry 2002;277(47):44638-50.
2002: Maria G Frid; Vishakha A Kale; Kurt R Stenmark
Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis.
Circulation research 2002;90(11):1189-96.
2002: M Das; Edward C Dempsey; John T Reeves; Kurt R Stenmark
Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia.
American journal of physiology. Lung cellular and molecular physiology 2002;282(5):L976-86.
2001: Dwight J Klemm; Peter A Watson; Maria G Frid; Edward C Dempsey; Jerome Schaack; LA Colton; Albina Nesterova; Kurt R Stenmark; Jane E B Reusch
cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration.
The Journal of biological chemistry 2001;276(49):46132-41.
2001: Todd C Carpenter; Kurt R Stenmark
Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak.
American journal of physiology. Lung cellular and molecular physiology 2001;281(4):L941-8.
2001: Mita Das; DM Bouchey; M J Moore; D C Hopkins; Raphael A Nemenoff; Kurt R Stenmark
Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases.
The Journal of biological chemistry 2001;276(19):15631-40.
2001: Arvind Kasaragod; M Scott Lucia; G Cabirac; Gary Grotendorst; Kurt R Stenmark
Connective tissue growth factor expression in pediatric myofibroblastic tumors.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2001;4(1):37-45.
2000: Mary C M Weiser-Evans; P E Schwartz; Nicole A Grieshaber; B E Quinn; Scott S Grieshaber; JK Belknap; P M Mourani; Richard A Majack; Kurt R Stenmark
Novel embryonic genes are preferentially expressed by autonomously replicating rat embryonic and neointimal smooth muscle cells.
Circulation research 2000;87(7):608-15.
2000: Matthew S Lemler; RD Bies; Maria G Frid; A Sastravaha; Lawrence S Zisman; Teresa J Bohlmeyer; A M Gerdes; John T Reeves; Kurt R Stenmark
Myocyte cytoskeletal disorganization and right heart failure in hypoxia-induced neonatal pulmonary hypertension.
American journal of physiology. Heart and circulatory physiology 2000;279(3):H1365-76.
2000: Todd C Carpenter; Kurt R Stenmark
Endothelin receptor blockade decreases lung water in young rats exposed to viral infection and hypoxia.
American journal of physiology. Lung cellular and molecular physiology 2000;279(3):L547-54.
2000: Mita Das; Edward C Dempsey; DM Bouchey; Mary E Reyland; Kurt R Stenmark
Chronic hypoxia induces exaggerated growth responses in pulmonary artery adventitial fibroblasts: potential contribution of specific protein kinase c isozymes.
American journal of respiratory cell and molecular biology 2000;22(1):15-25.
2000: Mary C M Weiser-Evans; B E Quinn; M R Burkard; Kurt R Stenmark
Transient reexpression of an embryonic autonomous growth phenotype by adult carotid artery smooth muscle cells after vascular injury.
Journal of cellular physiology 2000;182(1):12-23.
1999: Maria G Frid; Almaz A Aldashev; Raphael A Nemenoff; R Higashito; J Y Westcott; Kurt R Stenmark
Subendothelial cells from normal bovine arteries exhibit autonomous growth and constitutively activated intracellular signaling.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(12):2884-93.
1999: AG Durmowicz; Kurt R Stenmark
Mechanisms of structural remodeling in chronic pulmonary hypertension.
Pediatrics in review / American Academy of Pediatrics 1999;20(11):e91-e102.
1999: Eric A F Simoes; Anthony R Hayward; Esther M Ponnuraj; John P Straumanis; Kurt R Stenmark; H L Wilson; P G Babu
Respiratory syncytial virus infects the Bonnet monkey, Macaca radiata.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 1999;2(4):316-26.
1999: Arvind Kasaragod; M Scott Lucia; G M Lum; S Caldwell; Linda C Stork; Kurt R Stenmark
Solitary renal myofibromatosis: an unusual cause of infantile hypertension.
Pediatrics 1999;103(5):e66.
1999: Kurt R Stenmark; Maria G Frid; Raphael A Nemenoff; E C Dempsey; M Das
Hypoxia induces cell-specific changes in gene expression in vascular wall cells: implications for pulmonary hypertension.
Advances in experimental medicine and biology 1999;474():231-58.
1999: JK Belknap; Mary C M Weiser-Evans; Scott S Grieshaber; Richard A Majack; Kurt R Stenmark
Relationship between perlecan and tropoelastin gene expression and cell replication in the developing rat pulmonary vasculature.
American journal of respiratory cell and molecular biology 1999;20(1):24-34.
1998: AY Yu; M G Frid; Larissa A Shimoda; Charles M Wiener; Kurt R Stenmark; Gregg L Semenza
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung.
The American journal of physiology 1998;275(4 Pt 1):L818-26.
1998: Leopold Stiebellehner; John K Belknap; B Ensley; A Tucker; E C Orton; John T Reeves; Kurt R Stenmark
Lung endothelial cell proliferation in normal and pulmonary hypertensive neonatal calves.
The American journal of physiology 1998;275(3 Pt 1):L593-600.
1998: Kurt R Stenmark; Maria G Frid
Smooth muscle cell heterogeneity: role of specific smooth muscle cell subpopulations in pulmonary vascular disease.
Chest 1998;114(1 Suppl):82S-90S.
1998: Mita Das; Kurt R Stenmark; LJ Ruff; Edward C Dempsey
The Ca2+-dependent isozymes of protein kinase C are uniquely important in the enhanced growth of immature adventitial fibroblasts isolated from the bovine pulmonary arterial wall at a time of heightened susceptibility to vascular injury.
Chest 1998;114(1 Suppl):68S-69S.
1998: H A Guldemeester; Kurt R Stenmark; GH Brough; Rubin M Tuder; Troy Stevens
Role of adenylyl cyclase in proliferation of neonatal pulmonary artery smooth muscle cells.
Chest 1998;114(1 Suppl):38S-39S.
1998: Edward C Dempsey; Mita Das; Maria G Frid; Y Xu; Kurt R Stenmark
Hypoxic growth of bovine pulmonary artery smooth muscle cells: dependence on synergy, heterogeneity, and injury-induced phenotypic change.
Chest 1998;114(1 Suppl):29S-30S.
1998: Maria G Frid; Almaz A Aldashev; G F Cabirac; Edward C Dempsey; Kurt R Stenmark
Hypoxia stimulates proliferation of a unique cell population isolated from the bovine vascular media.
Chest 1998;114(1 Suppl):28S-29S.
1997: Mita Das; Kurt R Stenmark; LJ Ruff; Edward C Dempsey
Selected isozymes of PKC contribute to augmented growth of fetal and neonatal bovine PA adventitial fibroblasts.
The American journal of physiology 1997;273(6 Pt 1):L1276-84.
1997: Maria G Frid; Almaz A Aldashev; Edward C Dempsey; Kurt R Stenmark
Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities.
Circulation research 1997;81(6):940-52.
1997: Edward C Dempsey; Maria G Frid; Almaz A Aldashev; M Das; Kurt R Stenmark
Heterogeneity in the proliferative response of bovine pulmonary artery smooth muscle cells to mitogens and hypoxia: importance of protein kinase C.
Canadian journal of physiology and pharmacology 1997;75(7):936-44.
1997: Maria G Frid; E C Dempsey; AG Durmowicz; Kurt R Stenmark
Smooth muscle cell heterogeneity in pulmonary and systemic vessels. Importance in vascular disease.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(7):1203-9.
1997: Y Xu; Kurt R Stenmark; Mita Das; S J Walchak; LJ Ruff; Edward C Dempsey
Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties.
The American journal of physiology 1997;273(1 Pt 1):L234-45.
1997: Nicholas W Morrell; Sergei M Danilov; K B Satyan; Kenneth G Morris; Kurt R Stenmark
Right ventricular angiotensin converting enzyme activity and expression is increased during hypoxic pulmonary hypertension.
Cardiovascular research 1997;34(2):393-403.
1997: JK Belknap; E C Orton; B Ensley; A Tucker; Kurt R Stenmark
Hypoxia increases bromodeoxyuridine labeling indices in bovine neonatal pulmonary arteries.
American journal of respiratory cell and molecular biology 1997;16(4):366-71.
1997: Todd C Carpenter; Kurt R Stenmark
High-dose epinephrine is not superior to standard-dose epinephrine in pediatric in-hospital cardiopulmonary arrest.
Pediatrics 1997;99(3):403-8.
1997: Kurt R Stenmark; R P Mecham
Cellular and molecular mechanisms of pulmonary vascular remodeling.
Annual review of physiology 1997;59():89-144.
1996: AG Durmowicz; Maria G Frid; J D Wohrley; Kurt R Stenmark
Expression and localization of tropoelastin mRNA in the developing bovine pulmonary artery is dependent on vascular cell phenotype.
American journal of respiratory cell and molecular biology 1996;14(6):569-76.
1996: N W Morrell; S S Grieshaber; Sergei M Danilov; Richard A Majack; Kurt R Stenmark
Developmental regulation of angiotensin converting enzyme and angiotensin type 1 receptor in the rat pulmonary circulation.
American journal of respiratory cell and molecular biology 1996;14(6):526-37.
1996: AG Durmowicz; Kurt R Stenmark
Alterations in extracellular matrix protein expression in neonatal pulmonary hypertension: implications for vascular function.
Journal of perinatology : official journal of the California Perinatal Association 1996;16(2 Pt 2 Su):S11-8.
1996: Edward C Dempsey; Mita Das; Maria G Frid; Kurt R Stenmark
Unique growth properties of neonatal pulmonary vascular cells: importance of time- and site-specific responses, cell-cell interaction, and synergy.
Journal of perinatology : official journal of the California Perinatal Association 1996;16(2 Pt 2 Su):S2-11.
1995: Mita Das; Kurt R Stenmark; Edward C Dempsey
Enhanced growth of fetal and neonatal pulmonary artery adventitial fibroblasts is dependent on protein kinase C.
The American journal of physiology 1995;269(5 Pt 1):L660-7.
1995: N W Morrell; Elena N Atochina; Kenneth G Morris; Sergei M Danilov; Kurt R Stenmark
Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension.
The Journal of clinical investigation 1995;96(4):1823-33.
1995: N W Morrell; Kenneth G Morris; Kurt R Stenmark
Role of angiotensin-converting enzyme and angiotensin II in development of hypoxic pulmonary hypertension.
The American journal of physiology 1995;269(4 Pt 2):H1186-94.
1995: J D Wohrley; Maria G Frid; E P Moiseeva; E Christopher Orton; John K Belknap; Kurt R Stenmark
Hypoxia selectively induces proliferation in a specific subpopulation of smooth muscle cells in the bovine neonatal pulmonary arterial media.
The Journal of clinical investigation 1995;96(1):273-81.
1994: AG Durmowicz; William C Parks; D M Hyde; Robert P Mecham; Kurt R Stenmark
Persistence, re-expression, and induction of pulmonary arterial fibronectin, tropoelastin, and type I procollagen mRNA expression in neonatal hypoxic pulmonary hypertension.
The American journal of pathology 1994;145(6):1411-20.
1994: Maria G Frid; E P Moiseeva; Kurt R Stenmark
Multiple phenotypically distinct smooth muscle cell populations exist in the adult and developing bovine pulmonary arterial media in vivo.
Circulation research 1994;75(4):669-81.
1994: Edward C Dempsey; David B Badesch; E L Dobyns; Kurt R Stenmark
Enhanced growth capacity of neonatal pulmonary artery smooth muscle cells in vitro: dependence on cell size, time from birth, insulin-like growth factor I, and auto-activation of protein kinase C.
Journal of cellular physiology 1994;160(3):469-81.
1994: E L Dobyns; J Y Wescott; J M Kennaugh; M N Ross; Kurt R Stenmark
Eicosanoids decrease with successful extracorporeal membrane oxygenation therapy in neonatal pulmonary hypertension.
American journal of respiratory and critical care medicine 1994;149(4 Pt 1):873-80.
1994: Kurt R Stenmark; AG Durmowicz; J D Roby; Robert P Mecham; William C Parks
Persistence of the fetal pattern of tropoelastin gene expression in severe neonatal bovine pulmonary hypertension.
The Journal of clinical investigation 1994;93(3):1234-42.
1993: AG Durmowicz; E Christopher Orton; Kurt R Stenmark
Progressive loss of vasodilator responsive component of pulmonary hypertension in neonatal calves exposed to 4,570 m.
The American journal of physiology 1993;265(6 Pt 2):H2175-83.
1993: AG Durmowicz; S Hofmeister; T K Kadyraliev; Almaz A Aldashev; Kurt R Stenmark
Functional and structural adaptation of the yak pulmonary circulation to residence at high altitude.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(5):2276-85.
1992: M D Botney; William C Parks; E C Crouch; Kurt R Stenmark; Robert P Mecham
Transforming growth factor-beta 1 is decreased in remodeling hypertensive bovine pulmonary arteries.
The Journal of clinical investigation 1992;89(5):1629-35.
1992: Steven H Abman; Kurt R Stenmark
Changes in lung eicosanoid content during normal and abnormal transition in perinatal lambs.
The American journal of physiology 1992;262(2 Pt 1):L214-22.
1992: EA Perkett; David B Badesch; M K Roessler; Kurt R Stenmark; Barbara Meyrick
Insulin-like growth factor I and pulmonary hypertension induced by continuous air embolization in sheep.
American journal of respiratory cell and molecular biology 1992;6(1):82-7.
1991: AG Durmowicz; David B Badesch; William C Parks; Robert P Mecham; Kurt R Stenmark
Hypoxia-induced inhibition of tropoelastin synthesis by neonatal calf pulmonary artery smooth muscle cells.
American journal of respiratory cell and molecular biology 1991;5(5):464-9.
1991: Kurt R Stenmark; Almaz A Aldashev; E Christopher Orton; AG Durmowicz; David B Badesch; William C Parks; Robert P Mecham; Norbert F Voelkel; John T Reeves
Cellular adaptation during chronic neonatal hypoxic pulmonary hypertension.
The American journal of physiology 1991;261(4 Suppl):97-104.
1991: Robert P Mecham; Kurt R Stenmark; William C Parks
Connective tissue production by vascular smooth muscle in development and disease.
Chest 1991;99(3 Suppl):43S-47S.
1991: M Botney; W Parks; Kurt R Stenmark; Robert P Mecham
Determination of transforming growth factor-beta mRNA levels in pulmonary arteries from normal and hypoxic calves.
Chest 1991;99(3 Suppl):42S.
1991: B D Zuckerman; E Christopher Orton; Kurt R Stenmark; J A Trapp; J R Murphy; P R Coffeen; John T Reeves
Alteration of the pulsatile load in the high-altitude calf model of pulmonary hypertension.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;70(2):859-68.
1990: L M Graham; Adriana I Vasil; Michael Vasil; Norbert F Voelkel; Kurt R Stenmark
Decreased pulmonary vasoreactivity in an animal model of chronic Pseudomonas pneumonia.
The American review of respiratory disease 1990;142(1):221-9.
1990: Edward C Dempsey; Kurt R Stenmark; Ivan F McMurtry; R F O'Brien; N F Voelkel; David B Badesch
Insulin-like growth factor I and protein kinase C activation stimulate pulmonary artery smooth muscle cell proliferation through separate but synergistic pathways.
Journal of cellular physiology 1990;144(1):159-65.
1990: AG Durmowicz; J A St Cyr; David R Clarke; Kurt R Stenmark
Unilateral pulmonary hypertension as a result of chronic high flow to one lung.
The American review of respiratory disease 1990;142(1):230-3.
1990: S Cassin; Kurt R Stenmark; G Gause; L M Zapp; H Kuck; Jay Y Westcott
Leukotrienes and prostaglandins in fetal lung liquid.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;68(5):2214-22.
1990: P R Bakerman; Kurt R Stenmark; J H Fisher
Alpha-skeletal actin messenger RNA increases in acute right ventricular hypertrophy.
The American journal of physiology 1990;258(4 Pt 1):L173-8.
1989: I W Prosser; Kurt R Stenmark; M Suthar; E C Crouch; Robert P Mecham; William C Parks
Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization.
The American journal of pathology 1989;135(6):1073-88.
1989: David B Badesch; E Christopher Orton; L M Zapp; Jay Y Westcott; J Hester; Norbert F Voelkel; Kurt R Stenmark
Decreased arterial wall prostaglandin production in neonatal calves with severe chronic pulmonary hypertension.
American journal of respiratory cell and molecular biology 1989;1(6):489-98.
1989: William C Parks; Robert P Mecham; E C Crouch; E Christopher Orton; Kurt R Stenmark
Response of lobar vessels to hypoxic pulmonary hypertension.
The American review of respiratory disease 1989;140(5):1455-7.
1989: E C Crouch; William C Parks; J L Rosenbaum; D Chang; L Whitehouse; L J Wu; Kurt R Stenmark; E Christopher Orton; Robert P Mecham
Regulation of collagen production by medial smooth muscle cells in hypoxic pulmonary hypertension.
The American review of respiratory disease 1989;140(4):1045-51.
1989: David B Badesch; P D Lee; William C Parks; Kurt R Stenmark
Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells.
Biochemical and biophysical research communications 1989;160(1):382-7.
1989: N F Voelkel; Kurt R Stenmark; Jay Y Westcott; S W Chang
Lung eicosanoid metabolism.
Clinics in chest medicine 1989;10(1):95-105.
1988: E Christopher Orton; John T Reeves; Kurt R Stenmark
Pulmonary vasodilation with structurally altered pulmonary vessels and pulmonary hypertension.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(6):2459-67.
1988: Kurt R Stenmark; E Christopher Orton; John T Reeves; Norbert F Voelkel; E C Crouch; William C Parks; Robert P Mecham
Vascular remodeling in neonatal pulmonary hypertension. Role of the smooth muscle cell.
Chest 1988;93(3 Suppl):127S-133S.
1987: Jay Y Westcott; Robert C Murphy; Kurt R Stenmark
Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury.
Prostaglandins 1987;34(6):877-87.
1987: Robert P Mecham; L A Whitehouse; D S Wrenn; William C Parks; Gail L Griffin; Robert M Senior; E C Crouch; Kurt R Stenmark; Norbert F Voelkel
Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension.
Science (New York, N.Y.) 1987;237(4813):423-6.