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Gregory Stephanopoulos

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Procedures

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Devices

Oligonucleotide Array Sequence Analysis

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Biotechnology

Physiology

Chemicals & Drugs

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Co-Publications
Name
17
Sinskey, Anthony
15
Alper, Hal
13
Misra, Jatin
11
Hwang, Daehee
11
Schmitt, William
10
Yarmush, Martin
9
Wang, Daniel
9
Kelleher, Joanne
7
Follstad, Brian
7
Antoniewicz, Maciek
6
Gullans, Steven
6
Ajikumar, Parayil Kumaran
6
Alevizos, Ilias
6
Dangond, Fernando
6
Lee, Kyongbum

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Publications

TOP 3
Alper Hal; Stephanopoulos Gregory
Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential?
Tanzeglock Timm; Soos Miroslav; Stephanopoulos Gregory; Morbidelli Massimo
Induction of mammalian cell death by simple shear and extensional flows.
Tyo Keith E J; Jin Yong-Su; Espinoza Freddy A; Stephanopoulos Gregory
Identification of gene disruptions for increased poly-3-hydroxybutyrate accumulation in Synechocystis PCC 6803.

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All Publications

2009: Alper Hal; Stephanopoulos Gregory
Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential?
Nature reviews. Microbiology 2009;7(10):715-23.
2009: Tanzeglock Timm; Soos Miroslav; Stephanopoulos Gregory; Morbidelli Massimo
Induction of mammalian cell death by simple shear and extensional flows.
Biotechnology and bioengineering 2009;104(2):360-70.
2009: Tyo Keith E J; Jin Yong-Su; Espinoza Freddy A; Stephanopoulos Gregory
Identification of gene disruptions for increased poly-3-hydroxybutyrate accumulation in Synechocystis PCC 6803.
Biotechnology progress 2009;25(5):1236-43.
2009: Tyo Keith E J; Ajikumar Parayil Kumaran; Stephanopoulos Gregory
Stabilized gene duplication enables long-term selection-free heterologous pathway expression.
Nature biotechnology 2009;27(8):760-5.
2009: Klein-Marcuschamer Daniel; Santos Christine Nicole S; Yu Huimin; Stephanopoulos Gregory
Mutagenesis of the bacterial RNA polymerase alpha subunit for improvement of complex phenotypes.
Applied and environmental microbiology 2009;75(9):2705-11.
2009: Moxley Joel F; Jewett Michael C; Antoniewicz Maciek R; Villas-Boas Silas G; Alper Hal; Wheeler Robert T; Tong Lily; Hinnebusch Alan G; Ideker Trey; Nielsen Jens; Stephanopoulos Gregory
Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(16):6477-82.
2008: Stephanopoulos Gregory
Metabolic engineering: enabling technology for biofuels production.
Metabolic engineering 2008;10(6):293-4.
2008: Fischer Curt R; Klein-Marcuschamer Daniel; Stephanopoulos Gregory
Selection and optimization of microbial hosts for biofuels production.
Metabolic engineering 2008;10(6):295-304.
2008: Yu Huimin; Tyo Keith; Alper Hal; Klein-Marcuschamer Daniel; Stephanopoulos Gregory
A high-throughput screen for hyaluronic acid accumulation in recombinant Escherichia coli transformed by libraries of engineered sigma factors.
Biotechnology and bioengineering 2008;101(4):788-96.
2008: Yoo Hyuntae; Antoniewicz Maciek R; Stephanopoulos Gregory; Kelleher Joanne K
Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line.
The Journal of biological chemistry 2008;283(30):20621-7.
2008: Santos Christine Nicole S; Stephanopoulos Gregory
Combinatorial engineering of microbes for optimizing cellular phenotype.
Current opinion in chemical biology 2008;12(2):168-76.
2008: Alper Hal; Stephanopoulos Gregory
Uncovering the gene knockout landscape for improved lycopene production in E. coli.
Applied microbiology and biotechnology 2008;78(5):801-10.
2008: Ajikumar Parayil Kumaran; Tyo Keith; Carlsen Simon; Mucha Oliver; Phon Too Heng; Stephanopoulos Gregory
Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms.
Molecular pharmaceutics 2008;5(2):167-90.
2008: Styczynski Mark P; Jensen Kyle L; Rigoutsos Isidore; Stephanopoulos Gregory
BLOSUM62 miscalculations improve search performance.
Nature biotechnology 2008;26(3):274-5.
2008: Lütke-Eversloh Tina; Stephanopoulos Gregory
Combinatorial pathway analysis for improved L-tyrosine production in Escherichia coli: identification of enzymatic bottlenecks by systematic gene overexpression.
Metabolic engineering 2008;10(2):69-77.
2008: Klein-Marcuschamer Daniel; Stephanopoulos Gregory
Assessing the potential of mutational strategies to elicit new phenotypes in industrial strains.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2319-24.
2008: Biddinger Sudha B; Hernandez-Ono Antonio; Rask-Madsen Christian; Haas Joel T; Alemán José O; Suzuki Ryo; Scapa Erez F; Agarwal Chhavi; Carey Martin C; Stephanopoulos Gregory; Cohen David E; King George L; Ginsberg Henry N; Kahn C Ronald
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.
Cell metabolism 2008;7(2):125-34.
2008: Santos Christine Nicole S; Stephanopoulos Gregory
Melanin-based high-throughput screen for L-tyrosine production in Escherichia coli.
Applied and environmental microbiology 2008;74(4):1190-7.
2008: Young Jamey D; Walther Jason L; Antoniewicz Maciek R; Yoo Hyuntae; Stephanopoulos Gregory
An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis.
Biotechnology and bioengineering 2008;99(3):686-99.
2008: Yu Huimin; Stephanopoulos Gregory
Metabolic engineering of Escherichia coli for biosynthesis of hyaluronic acid.
Metabolic engineering 2008;10(1):24-32.
2007: Ng Jin Kiat; Ajikumar Parayil Kumaran; Tang Yew Chung; Lee Jim Yang; Stephanopoulos Gregory; Too Heng-Phon
Spatially addressable protein array: ssDNA-directed assembly for antibody microarray.
Electrophoresis 2007;28(24):4638-44.
2007: Lütke-Eversloh Tina; Santos Christine Nicole S; Stephanopoulos Gregory
Perspectives of biotechnological production of L-tyrosine and its applications.
Applied microbiology and biotechnology 2007;77(4):751-62.
2007: Lütke-Eversloh Tina; Stephanopoulos Gregory
A semi-quantitative high-throughput screening method for microbial L-tyrosine production in microtiter plates.
Journal of industrial microbiology & biotechnology 2007;34(12):807-11.
2007: Antoniewicz Maciek R; Kelleher Joanne K; Stephanopoulos Gregory
Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis.
Analytical chemistry 2007;79(19):7554-9.
2007: Ng Jin Kiat; Ajikumar Parayil Kumaran; Stephanopoulos Gregory; Too Heng-Phon
Profiling RNA polymerase-promoter interaction by using ssDNA-dsDNA probe on a surface addressable microarray.
Chembiochem : a European journal of chemical biology 2007;8(14):1667-70.
2007: Klein-Marcuschamer Daniel; Ajikumar Parayil Kumaran; Stephanopoulos Gregory
Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene.
Trends in biotechnology 2007;25(9):417-24.
2007: Misra Jatin; Alevizos Ilias; Hwang Daehee; Stephanopoulos George; Stephanopoulos Gregory
Linking physiology and transcriptional profiles by quantitative predictive models.
Biotechnology and bioengineering 2007;98(1):252-60.
2007: Misra Jatin; Alevizos Ilias; Hwang Daehee; Stephanopoulos George; Stephanopoulos Gregory
Linking physiology and transcriptional profiles by quantitative predictive models.
Biotechnology and bioengineering 2007;98(1):252-60.
2007: Alevizos Ilias; Misra Jatin; Bullen John; Basso Giuseppe; Kelleher Joanne; Mantzoros Christos; Stephanopoulos Gregory
Linking hepatic transcriptional changes to high-fat diet induced physiology for diabetes-prone and obese-resistant mice.
Cell cycle (Georgetown, Tex.) 2007;6(13):1631-8.
2007: Jin Yong-Su; Stephanopoulos Gregory
Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli.
Metabolic engineering 2007;9(4):337-47.
2007: Antoniewicz Maciek R; Kraynie David F; Laffend Lisa A; González-Lergier Joanna; Kelleher Joanne K; Stephanopoulos Gregory
Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol.
Metabolic engineering 2007;9(3):277-92.
2007: Ajikumar Parayil Kumaran; Ng Jin Kiat; Tang Yew Chung; Lee Jim Yang; Stephanopoulos Gregory; Too Heng-Phon
Carboxyl-terminated dendrimer-coated bioactive interface for protein microarray: high-sensitivity detection of antigen in complex biological samples.
Langmuir : the ACS journal of surfaces and colloids 2007;23(10):5670-7.
2007: Alper Hal; Stephanopoulos Gregory
Global transcription machinery engineering: a new approach for improving cellular phenotype.
Metabolic engineering 2007;9(3):258-67.
2007: Lütke-Eversloh Tina; Stephanopoulos Gregory
L-tyrosine production by deregulated strains of Escherichia coli.
Applied microbiology and biotechnology 2007;75(1):103-10.
2007: Taniguchi Cullen M; Aleman José O; Ueki Kohjiro; Luo Ji; Asano Tomoichiro; Kaneto Hideaki; Stephanopoulos Gregory; Cantley Lewis C; Kahn C Ronald
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
Molecular and cellular biology 2007;27(8):2830-40.
2007: Loose Christopher R; Langer Robert S; Stephanopoulos Gregory N
Optimization of protein fusion partner length for maximizing in vitro translation of peptides.
Biotechnology progress 2007;23(2):444-51.
2007: Tyo Keith E; Alper Hal S; Stephanopoulos Gregory N
Expanding the metabolic engineering toolbox: more options to engineer cells.
Trends in biotechnology 2007;25(3):132-7.
2007: Stephanopoulos Gregory
Challenges in engineering microbes for biofuels production.
Science (New York, N.Y.) 2007;315(5813):801-4.
2007: Styczynski Mark P; Moxley Joel F; Tong Lily V; Walther Jason L; Jensen Kyle L; Stephanopoulos Gregory N
Systematic identification of conserved metabolites in GC/MS data for metabolomics and biomarker discovery.
Analytical chemistry 2007;79(3):966-73.
2007: Nevoigt Elke; Fischer Curt; Mucha Oliver; Matthäus Falk; Stahl Ulf; Stephanopoulos Gregory
Engineering promoter regulation.
Biotechnology and bioengineering 2007;96(3):550-8.
2007: Antoniewicz Maciek R; Kelleher Joanne K; Stephanopoulos Gregory
Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions.
Metabolic engineering 2007;9(1):68-86.
2006: Alper Hal; Moxley Joel; Nevoigt Elke; Fink Gerald R; Stephanopoulos Gregory
Engineering yeast transcription machinery for improved ethanol tolerance and production.
Science (New York, N.Y.) 2006;314(5805):1565-8.
2006: Loose Christopher; Jensen Kyle; Rigoutsos Isidore; Stephanopoulos Gregory
A linguistic model for the rational design of antimicrobial peptides.
Nature 2006;443(7113):867-9.
2006: Alper Hal; Miyaoku Kohei; Stephanopoulos Gregory
Characterization of lycopene-overproducing E. coli strains in high cell density fermentations.
Applied microbiology and biotechnology 2006;72(5):968-74.
2006: Nevoigt Elke; Kohnke Jessica; Fischer Curt R; Alper Hal; Stahl Ulf; Stephanopoulos Gregory
Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae.
Applied and environmental microbiology 2006;72(8):5266-73.
2006: Antoniewicz Maciek R; Kelleher Joanne K; Stephanopoulos Gregory
Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements.
Metabolic engineering 2006;8(4):324-37.
2006: Jensen Kyle; Alper Hal; Fischer Curt; Stephanopoulos Gregory
Identifying functionally important mutations from phenotypically diverse sequence data.
Applied and environmental microbiology 2006;72(5):3696-701.
2006: Tyo Keith E; Zhou Hang; Stephanopoulos Gregory N
High-throughput screen for poly-3-hydroxybutyrate in Escherichia coli and Synechocystis sp. strain PCC6803.
Applied and environmental microbiology 2006;72(5):3412-7.
2006: Fischer Curt R; Alper Hal; Nevoigt Elke; Jensen Kyle L; Stephanopoulos Gregory
Response to Hammer et al.: Tuning genetic control--importance of thorough promoter characterization versus generating promoter diversity.
Trends in biotechnology 2006;24(2):55-6.
2006: Jensen Kyle L; Styczynski Mark P; Rigoutsos Isidore; Stephanopoulos Gregory N
A generic motif discovery algorithm for sequential data.
Bioinformatics (Oxford, England) 2006;22(1):21-8.
2006: Styczynski Mark P; Fischer Curt R; Stephanopoulos Gregory N
The intelligent design of evolution.
Molecular systems biology 2006;2():2006.0020.
2005: Jin Yong-Su; Alper Hal; Yang Yea-Tyng; Stephanopoulos Gregory
Improvement of xylose uptake and ethanol production in recombinant Saccharomyces cerevisiae through an inverse metabolic engineering approach.
Applied and environmental microbiology 2005;71(12):8249-56.
2005: Lütke-Eversloh Tina; Stephanopoulos Gregory
Feedback inhibition of chorismate mutase/prephenate dehydrogenase (TyrA) of Escherichia coli: generation and characterization of tyrosine-insensitive mutants.
Applied and environmental microbiology 2005;71(11):7224-8.
2005: Alper Hal; Fischer Curt; Nevoigt Elke; Stephanopoulos Gregory
Tuning genetic control through promoter engineering.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12678-83.
2005: Camelo Sandra; Iglesias Antonio H; Hwang Daehee; Due Brice; Ryu Hoon; Smith Karen; Gray Steven G; Imitola Jaime; Duran German; Assaf Basel; Langley Brett; Khoury Samia J; Stephanopoulos George; De Girolami Umberto; Ratan Rajiv R; Ferrante Robert J; Dangond Fernando
Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2005;164(1-2):10-21.
2005: Ismail Ahmed E; Stephanopoulos George; Rutledge Gregory C
Topological coarse graining of polymer chains using wavelet-accelerated Monte Carlo. II. Self-avoiding chains.
The Journal of chemical physics 2005;122(23):234902.
2005: Ismail Ahmed E; Rutledge Gregory C; Stephanopoulos George
Topological coarse graining of polymer chains using wavelet-accelerated Monte Carlo. I. Freely jointed chains.
The Journal of chemical physics 2005;122(23):234901.
2005: Raab R Michael; Bullen John; Kelleher Joanne; Mantzoros Christos; Stephanopoulos Gregory
Regulation of mouse hepatic genes in response to diet induced obesity, insulin resistance and fasting induced weight reduction.
Nutrition & metabolism 2005;2():15.
2005: Koffas Mattheos; Stephanopoulos Gregory
Strain improvement by metabolic engineering: lysine production as a case study for systems biology.
Current opinion in biotechnology 2005;16(3):361-6.
2005: Villas-Bôas Silas G; Moxley Joel F; Akesson Mats; Stephanopoulos Gregory; Nielsen Jens
High-throughput metabolic state analysis: the missing link in integrated functional genomics of yeasts.
The Biochemical journal 2005;388(Pt 2):669-77.
2005: Alper Hal; Jin Yong-Su; Moxley J F; Stephanopoulos G
Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli.
Metabolic engineering 2005;7(3):155-64.
2005: Alper Hal; Miyaoku Kohei; Stephanopoulos Gregory
Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets.
Nature biotechnology 2005;23(5):612-6.
2005: Raab R Michael; Tyo Keith; Stephanopoulos Gregory
Metabolic engineering.
Advances in biochemical engineering/biotechnology 2005;100():1-17.
2004: Stephanopoulos Gregory; Alper Hal; Moxley Joel
Exploiting biological complexity for strain improvement through systems biology.
Nature biotechnology 2004;22(10):1261-7.
2004: Raab R Michael; Stephanopoulos Gregory
Dynamics of gene silencing by RNA interference.
Biotechnology and bioengineering 2004;88(1):121-32.
2004: Bullen John W; Ziotopoulou Mary; Ungsunan Linda; Misra Jatin; Alevizos Ilias; Kokkotou Efi; Maratos-Flier Eleftheria; Stephanopoulos Gregory; Mantzoros Christos S
Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides.
American journal of physiology. Endocrinology and metabolism 2004;287(4):E662-70.
2004: Schmitt William A; Raab R Michael; Stephanopoulos Gregory
Elucidation of gene interaction networks through time-lagged correlation analysis of transcriptional data.
Genome research 2004;14(8):1654-63.
2004: Lynch Michael D; Gill Ryan T; Stephanopoulos Gregory
Mapping phenotypic landscapes using DNA micro-arrays.
Metabolic engineering 2004;6(3):177-85.
2004: Yoo Hyuntae; Stephanopoulos Gregory; Kelleher Joanne K
Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes.
Journal of lipid research 2004;45(7):1324-32.
2004: Iglesias Antonio H; Camelo Sandra; Hwang Daehee; Villanueva Raul; Stephanopoulos George; Dangond Fernando
Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells.
Journal of neuroimmunology 2004;150(1-2):163-77.
2004: Jung Gyoo Yeol; Stephanopoulos Gregory
A functional protein chip for pathway optimization and in vitro metabolic engineering.
Science (New York, N.Y.) 2004;304(5669):428-31.
2004: Lee Kyongbum; Hwang Daehee; Yokoyama Tadaaki; Stephanopoulos George; Stephanopoulos Gregory N; Yarmush Martin L
Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data.
Bioinformatics (Oxford, England) 2004;20(6):959-69.
2004: Lee Kyongbum; Hwang Daehee; Yokoyama Tadaaki; Stephanopoulos George; Stephanopoulos Gregory N; Yarmush Martin L
Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data.
Bioinformatics (Oxford, England) 2004;20(6):959-69.
2004: Hwang Daehee; Stephanopoulos George; Chan Christina
Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function.
Bioinformatics (Oxford, England) 2004;20(4):487-99.
2004: Padilla Leandro; Krämer Reinhard; Stephanopoulos Gregory; Agosin Eduardo
Overproduction of trehalose: heterologous expression of Escherichia coli trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase in Corynebacterium glutamicum.
Applied and environmental microbiology 2004;70(1):370-6.
2004: Dangond Fernando; Hwang Daehee; Camelo Sandra; Pasinelli Piera; Frosch Matthew P; Stephanopoulos Gregory; Stephanopoulos George; Brown Robert H; Gullans Steven R
Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter.
Physiological genomics 2004;16(2):229-39.
2004: Dangond Fernando; Hwang Daehee; Camelo Sandra; Pasinelli Piera; Frosch Matthew P; Stephanopoulos Gregory; Stephanopoulos George; Brown Robert H; Gullans Steven R
Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter.
Physiological genomics 2004;16(2):229-39.
2004: Wong Matthew S; Raab R Michael; Rigoutsos Isidore; Stephanopoulos Gregory N; Kelleher Joanne K
Metabolic and transcriptional patterns accompanying glutamine depletion and repletion in mouse hepatoma cells: a model for physiological regulatory networks.
Physiological genomics 2004;16(2):247-55.
2004: Styczynski Mark P; Jensen Kyle L; Rigoutsos Isidore; Stephanopoulos Gregory N
An extension and novel solution to the (l,d)-motif challenge problem.
Genome informatics. International Conference on Genome Informatics 2004;15(2):63-71.
2003: Schmitt William A; Stephanopoulos Gregory
Prediction of transcriptional profiles of Synechocystis PCC6803 by dynamic autoregressive modeling of DNA microarray data.
Biotechnology and bioengineering 2003;84(7):855-63.
2003: Lee Kyongbum; Berthiaume François; Stephanopoulos Gregory N; Yarmush Martin L
Induction of a hypermetabolic state in cultured hepatocytes by glucagon and H2O2.
Metabolic engineering 2003;5(4):221-9.
2003: Klapa Maria I; Aon Juan-Carlos; Stephanopoulos Gregory
Systematic quantification of complex metabolic flux networks using stable isotopes and mass spectrometry.
European journal of biochemistry / FEBS 2003;270(17):3525-42.
2003: Lee Kyongbum; Berthiaume François; Stephanopoulos Gregory N; Yarmush Martin L
Profiling of dynamic changes in hypermetabolic livers.
Biotechnology and bioengineering 2003;83(4):400-15.
2003: Klapa Maria I; Aon Juan-Carlos; Stephanopoulos Gregory
Ion-trap mass spectrometry used in combination with gas chromatography for high-resolution metabolic flux determination.
BioTechniques 2003;34(4):832-6, 838, 840 passim.
2003: Hwang Daehee; Alevizos Ilias; Schmitt William A; Misra Jatin; Ohyama Hiroe; Todd Randy; Mahadevappa Mamatha; Warrington Janet A; Stephanopoulos George; Wong David T; Stephanopoulos Gregory
Genomic dissection for characterization of cancerous oral epithelium tissues using transcription profiling.
Oral oncology 2003;39(3):259-68.
2003: Hwang Daehee; Alevizos Ilias; Schmitt William A; Misra Jatin; Ohyama Hiroe; Todd Randy; Mahadevappa Mamatha; Warrington Janet A; Stephanopoulos George; Wong David T; Stephanopoulos Gregory
Genomic dissection for characterization of cancerous oral epithelium tissues using transcription profiling.
Oral oncology 2003;39(3):259-68.
2003: Chan Christina; Hwang Daehee; Stephanopoulos Gregory N; Yarmush Martin L; Stephanopoulos George
Application of multivariate analysis to optimize function of cultured hepatocytes.
Biotechnology progress 2003;19(2):580-98.
2003: Chan Christina; Hwang Daehee; Stephanopoulos Gregory N; Yarmush Martin L; Stephanopoulos George
Application of multivariate analysis to optimize function of cultured hepatocytes.
Biotechnology progress 2003;19(2):580-98.
2003: Koffas Mattheos A G; Jung Gyoo Yeol; Stephanopoulos Gregory
Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression.
Metabolic engineering 2003;5(1):32-41.
2003: Varela C; Agosin E; Baez M; Klapa M; Stephanopoulos G
Metabolic flux redistribution in Corynebacterium glutamicum in response to osmotic stress.
Applied microbiology and biotechnology 2003;60(5):547-55.
2002: Koffas Mattheos A G; Jung Gyoo Yeol; Aon Juan C; Stephanopoulos Gregory
Effect of pyruvate carboxylase overexpression on the physiology of Corynebacterium glutamicum.
Applied and environmental microbiology 2002;68(11):5422-8.
2002: Hwang Daehee; Schmitt William A; Stephanopoulos George; Stephanopoulos Gregory
Determination of minimum sample size and discriminatory expression patterns in microarray data.
Bioinformatics (Oxford, England) 2002;18(9):1184-93.
2002: Hwang Daehee; Schmitt William A; Stephanopoulos George; Stephanopoulos Gregory
Determination of minimum sample size and discriminatory expression patterns in microarray data.
Bioinformatics (Oxford, England) 2002;18(9):1184-93.
2002: Stephanopoulos Gregory; Hwang Daehee; Schmitt William A; Misra Jatin; Stephanopoulos George
Mapping physiological states from microarray expression measurements.
Bioinformatics (Oxford, England) 2002;18(8):1054-63.
2002: Stephanopoulos Gregory; Hwang Daehee; Schmitt William A; Misra Jatin; Stephanopoulos George
Mapping physiological states from microarray expression measurements.
Bioinformatics (Oxford, England) 2002;18(8):1054-63.
2002: Yuk Inn H Y; Wildt Stefan; Jolicoeur Mario; Wang Daniel I C; Stephanopoulos Gregory
A GFP-based screen for growth-arrested, recombinant protein-producing cells.
Biotechnology and bioengineering 2002;79(1):74-82.
2002: Misra Jatin; Schmitt William; Hwang Daehee; Hsiao Li-Li; Gullans Steve; Stephanopoulos George; Stephanopoulos Gregory
Interactive exploration of microarray gene expression patterns in a reduced dimensional space.
Genome research 2002;12(7):1112-20.
2002: Misra Jatin; Schmitt William; Hwang Daehee; Hsiao Li-Li; Gullans Steve; Stephanopoulos George; Stephanopoulos Gregory
Interactive exploration of microarray gene expression patterns in a reduced dimensional space.
Genome research 2002;12(7):1112-20.
2002: Stephanopoulos Gregory
Metabolic engineering by genome shuffling.
Nature biotechnology 2002;20(7):666-8.
2002: Gill Ryan T; Katsoulakis Eva; Schmitt William; Taroncher-Oldenburg Gaspar; Misra Jatin; Stephanopoulos Gregory
Genome-wide dynamic transcriptional profiling of the light-to-dark transition in Synechocystis sp. strain PCC 6803.
Journal of bacteriology 2002;184(13):3671-81.
2002: Gill R T; Wildt S; Yang Y T; Ziesman S; Stephanopoulos G
Genome-wide screening for trait conferring genes using DNA microarrays.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):7033-8.
2002: Stafford Daniel E; Yanagimachi Kurt S; Lessard Philip A; Rijhwani Sushil K; Sinskey Anthony J; Stephanopoulos Gregory
Optimizing bioconversion pathways through systems analysis and metabolic engineering.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):1801-6.
2002: Follstad Brian D; Wang Daniel I C; Stephanopoulos Gregory
Mitochondrial membrane potential selects hybridomas yielding high viability in fed-batch cultures.
Biotechnology progress 2002;18(1):1-5.
2002: Walton S Patrick; Stephanopoulos Gregory N; Yarmush Martin L; Roth Charles M
Thermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNA.
Biophysical journal 2002;82(1 Pt 1):366-77.
2001: Hsiao L L; Dangond F; Yoshida T; Hong R; Jensen R V; Misra J; Dillon W; Lee K F; Clark K E; Haverty P; Weng Z; Mutter G L; Frosch M P; Macdonald M E; Milford E L; Crum C P; Bueno R; Pratt R E; Mahadevappa M; Warrington J A; Stephanopoulos G; Stephanopoulos G; Gullans S R
A compendium of gene expression in normal human tissues.
Physiological genomics 2001;7(2):97-104.
2001: Hsiao L L; Dangond F; Yoshida T; Hong R; Jensen R V; Misra J; Dillon W; Lee K F; Clark K E; Haverty P; Weng Z; Mutter G L; Frosch M P; Macdonald M E; Milford E L; Crum C P; Bueno R; Pratt R E; Mahadevappa M; Warrington J A; Stephanopoulos G; Stephanopoulos G; Gullans S R
A compendium of gene expression in normal human tissues.
Physiological genomics 2001;7(2):97-104.
2001: Yanagimachi K S; Stafford D E; Dexter A F; Sinskey A J; Drew S; Stephanopoulos G
Application of radiolabeled tracers to biocatalytic flux analysis.
European journal of biochemistry / FEBS 2001;268(18):4950-60.
2001: Stephanopoulos G; Kelleher J
Biochemistry. How to make a superior cell.
Science (New York, N.Y.) 2001;292(5524):2024-5.
2001: Stafford D E; Stephanopoulos G
Metabolic engineering as an integrating platform for strain development.
Current opinion in microbiology 2001;4(3):336-40.
2001: Stafford D E; Yanagimachi K S; Stephanopoulos G
Metabolic engineering of indene bioconversion in Rhodococcus sp.
Advances in biochemical engineering/biotechnology 2001;73():85-101.
2001: Balcarcel R R; Stephanopoulos G
Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production.
Biotechnology and bioengineering 2001;76(1):1-10.
2000: Reinecke M; Stephanopoulos G
Flow injection analysis for simultaneous quantification of prolactin concentration and glycosylation macroheterogeneity in cell culture samples.
Cytotechnology 2000;34(3):237-42.
2000: Taroncher-Oldenburg G; Stephanopoulos G
Targeted, PCR-based gene disruption in cyanobacteria: inactivation of the polyhydroxyalkanoic acid synthase genes in Synechocystis sp. PCC6803.
Applied microbiology and biotechnology 2000;54(5):677-80.
2000: Follstad B D; Wang D I; Stephanopoulos G
Mitochondrial membrane potential differentiates cells resistant to apoptosis in hybridoma cultures.
European journal of biochemistry / FEBS 2000;267(22):6534-40.
2000: Sanfeliu A; Chung J D; Stephanopoulos G
Effect of insulin stimulation on the proliferation and death of Chinese hamster ovary cells.
Biotechnology and bioengineering 2000;70(4):421-7.
2000: Lee K; Berthiaume F; Stephanopoulos G N; Yarmush D M; Yarmush M L
Metabolic flux analysis of postburn hepatic hypermetabolism.
Metabolic engineering 2000;2(4):312-27.
2000: Taroncher-Oldenburg G; Nishina K; Stephanopoulos G
Identification and analysis of the polyhydroxyalkanoate-specific beta-ketothiolase and acetoacetyl coenzyme A reductase genes in the cyanobacterium Synechocystis sp. strain PCC6803.
Applied and environmental microbiology 2000;66(10):4440-8.
2000: Kamimura R T; Bicciato S; Shimizu H; Alford J; Stephanopoulos G
Mining of biological data II: assessing data structure and class homogeneity by cluster analysis.
Metabolic engineering 2000;2(3):228-38.
2000: Kamimura R T; Bicciato S; Shimizu H; Alford J; Stephanopoulos G
Mining of biological data I: identifying discriminating features via mean hypothesis testing.
Metabolic engineering 2000;2(3):218-27.
1999: Walton S P; Stephanopoulos G N; Yarmush M L; Roth C M
Prediction of antisense oligonucleotide binding affinity to a structured RNA target.
Biotechnology and bioengineering 1999;65(1):1-9.
1999: Lee K; Berthiaume F; Stephanopoulos G N; Yarmush M L
Metabolic flux analysis: a powerful tool for monitoring tissue function.
Tissue engineering 1999;5(4):347-68.
1999: Sanfeliu A; Stephanopoulos G
Effect of glutamine limitation on the death of attached Chinese hamster ovary cells.
Biotechnology and bioengineering 1999;64(1):46-53.
1999: Treadway S L; Yanagimachi K S; Lankenau E; Lessard P A; Stephanopoulos G; Sinskey A J
Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24.
Applied microbiology and biotechnology 1999;51(6):786-93.
1999: Follstad B D; Balcarcel R R; Stephanopoulos G; Wang D I
Metabolic flux analysis of hybridoma continuous culture steady state multiplicity.
Biotechnology and bioengineering 1999;63(6):675-83.
1999: Simpson T W; Follstad B D; Stephanopoulos G
Analysis of the pathway structure of metabolic networks.
Journal of biotechnology 1999;71(1-3):207-23.
1999: Shaw-Reid C A; McCormick M M; Sinskey A J; Stephanopoulos G
Flux through the tetrahydrodipicolinate succinylase pathway is dispensable for L-lysine production in Corynebacterium glutamicum.
Applied microbiology and biotechnology 1999;51(3):325-33.
1999: Goswami J; Sinskey A J; Steller H; Stephanopoulos G N; Wang D I
Apoptosis in batch cultures of Chinese hamster ovary cells.
Biotechnology and bioengineering 1999;62(6):632-40.
1999: Nyberg G B; Balcarcel R R; Follstad B D; Stephanopoulos G; Wang D I
Metabolic effects on recombinant interferon-gamma glycosylation in continuous culture of Chinese hamster ovary cells.
Biotechnology and bioengineering 1999;62(3):336-47.
1999: Nyberg G B; Balcarcel R R; Follstad B D; Stephanopoulos G; Wang D I
Metabolism of peptide amino acids by Chinese hamster ovary cells grown in a complex medium.
Biotechnology and bioengineering 1999;62(3):324-35.
1999: Park S M; Klapa M I; Sinskey A J; Stephanopoulos G
Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications.
Biotechnology and bioengineering 1999;62(4):392-401.
1999: Stephanopoulos G
Metabolic fluxes and metabolic engineering.
Metabolic engineering 1999;1(1):1-11.
1999: Koffas M; Roberge C; Lee K; Stephanopoulos G
Metabolic engineering.
Annual review of biomedical engineering 1999;1():535-57.
1998: Koffas M A; Ramamoorthi R; Pine W A; Sinskey A J; Stephanopoulos G
Sequence of the Corynebacterium glutamicum pyruvate carboxylase gene.
Applied microbiology and biotechnology 1998;50(3):346-52.
1998: Follstad B D; Stephanopoulos G
Effect of reversible reactions on isotope label redistribution--analysis of the pentose phosphate pathway.
European journal of biochemistry / FEBS 1998;252(3):360-71.
1998: Chung J D; Sinskey A J; Stephanopoulos G
Growth factor and bcl-2 mediated survival during abortive proliferation of hybridoma cell line.
Biotechnology and bioengineering 1998;57(2):164-71.
1997: Park S M; Sinskey A J; Stephanopoulos G
Metabolic and physiological studies of Corynebacterium glutamicum mutants.
Biotechnology and bioengineering 1997;55(6):864-79.
1997: Chung J D; Zabel C; Sinskey A J; Stephanopoulos G
Extension of Sp2/0 hybridoma cell viability through interleukin-6 supplementation.
Biotechnology and bioengineering 1997;55(2):439-46.
1997: Stephanopoulos G; Locher G; Duff M J; Kamimura R; Stephanopoulos G
Fermentation database mining by pattern recognition.
Biotechnology and bioengineering 1997;53(5):443-52.
1997: Grampp G E; Lodish H F; Stephanopoulos G
Processing and secretion of insulin-related peptides in an insulinoma cell line.
Biotechnology and bioengineering 1997;53(3):283-9.
1997: Grampp G E; Lodish H F; Stephanopoulos G
Analysis of secretory dynamics and development of media for the controlled secretion of insulin-related peptides from betaTC-3 insulinoma cells.
Biotechnology and bioengineering 1997;53(3):274-82.
1996: Grampp G E; Applegate M A; Stephanopoulos G
Cyclic operation of ceramic-matrix animal cell bioreactors for controlled secretion of an endocrine hormone. A comparison of single-pass and recycle modes of operation.
Biotechnology progress 1996;12(6):837-46.
1996: Shelikoff M; Sinskey A J; Stephanopoulos G
A modeling framework for the study of protein glycosylation.
Biotechnology and bioengineering 1996;50(1):73-90.
1996: Kamimura R; Konstantinov K; Stephanopoulos G
Knowledge-based systems, artificial neural networks and pattern recognition: applications to biotechnological processes.
Current opinion in biotechnology 1996;7(2):231-4.
1995: Zupke C; Sinskey A J; Stephanopoulos G
Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas.
Applied microbiology and biotechnology 1995;44(1-2):27-36.
1995: Chen K; Stephanopoulos G N; Sinskey A J; Lodish H F
Regulated secretion of prolactin by the mouse insulinoma cell line beta TC-3.
Bio/technology (Nature Publishing Company) 1995;13(11):1191-7.
1995: Chung J D; Conner S; Stephanopoulos G
Flow cytometric study of differentiating cultures of Bacillus subtilis.
Cytometry 1995;20(4):324-33.
1995: Colón G E; Nguyen T T; Jetten M S; Sinskey A J; Stephanopoulos G
Production of isoleucine by overexpression of ilvA in a Corynebacterium lactofermentum threonine producer.
Applied microbiology and biotechnology 1995;43(3):482-8.
1995: Simpson T W; Colón G E; Stephanopoulos G
Two paradigms of metabolic engineering applied to amino acid biosynthesis.
Biochemical Society transactions 1995;23(2):381-7.
1995: Colón G E; Jetten M S; Nguyen T T; Gubler M E; Follettie M T; Sinskey A J; Stephanopoulos G
Effect of inducible thrB expression on amino acid production in Corynebacterium lactofermentum ATCC 21799.
Applied and environmental microbiology 1995;61(1):74-8.
1994: Singhvi R; Kumar A; Lopez G P; Stephanopoulos G N; Wang D I; Whitesides G M; Ingber D E
Engineering cell shape and function.
Science (New York, N.Y.) 1994;264(5159):696-8.
1994: Chung J D; Stephanopoulos G; Ireton K; Grossman A D
Gene expression in single cells of Bacillus subtilis: evidence that a threshold mechanism controls the initiation of sporulation.
Journal of bacteriology 1994;176(7):1977-84.
1994: Stephanopoulos G
Metabolic engineering.
Current opinion in biotechnology 1994;5(2):196-200.
1994: Shelikoff M; Sinskey A J; Stephanopoulos G
The effect of protein synthesis inhibitors on the glycosylation site occupancy of recombinant human prolactin.
Cytotechnology 1994;15(1-3):195-208.
1993: Stephanopoulos G; Sinskey A J
Metabolic engineering--methodologies and future prospects.
Trends in biotechnology 1993;11(9):392-6.
1992: Grampp G E; Stephanopoulos G
Development and scaleup of controlled secretion processes for improved product recovery in animal cell culture.
Annals of the New York Academy of Sciences 1992;665():81-93.
1992: Kennedy M J; Thakur M S; Wang D I; Stephanopoulos G N
Techniques for the estimation of cell concentration in the presence of suspended solids.
Biotechnology progress 1992;8(5):375-81.
1992: Grampp G E; Sambanis A; Stephanopoulos G N
Use of regulated secretion in protein production from animal cells: an overview.
Advances in biochemical engineering/biotechnology 1992;46():35-62.
1991: Stephanopoulos G; Vallino J J
Network rigidity and metabolic engineering in metabolite overproduction.
Science (New York, N.Y.) 1991;252(5013):1675-81.
1990: Sambanis A; Stephanopoulos G; Lodish H F
Multiple episodes of induced secretion of human growth hormone from recombinant AtT-20 cells.
Cytotechnology 1990;4(2):111-9.
1987: Vallino J J; Stephanopoulos G N
Intelligent sensors in biotechnology. Applications for the monitoring of fermentations and cellular metabolism.
Annals of the New York Academy of Sciences 1987;506():415-30.

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