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Brigitte Boldyreff

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Brigitte Boldyreff; Tine L Rasmussen; Hans H Jensen; Alexandre Cloutier; Lucille Beaudet; Philippe Roby; Olaf-Georg Issinger
Expression and purification of PI3 kinase alpha and development of an ATP depletion and an alphascreen PI3 kinase activity assay.
Birgitte B Olsen; Martin R Larsen; Brigitte Boldyreff; Karsten Niefind; Olaf-Georg Issinger
Exploring the intramolecular phosphorylation sites in human Chk2.
Tatiana Cheusova; Muhammad Amir Khan; Steffen Wolfgang Schubert; Anne-Claude Gavin; Thierry Buchou; Germaine Jacob; Heinrich Sticht; Jorge E Allende; Brigitte Boldyreff; Hans Rudolf Brenner; Said Hashemolhosseini
Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction.

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2008: Brigitte Boldyreff; Tine L Rasmussen; Hans H Jensen; Alexandre Cloutier; Lucille Beaudet; Philippe Roby; Olaf-Georg Issinger
Expression and purification of PI3 kinase alpha and development of an ATP depletion and an alphascreen PI3 kinase activity assay.
Journal of biomolecular screening 2008;13(10):1035-40.
2008: Birgitte B Olsen; Martin R Larsen; Brigitte Boldyreff; Karsten Niefind; Olaf-Georg Issinger
Exploring the intramolecular phosphorylation sites in human Chk2.
Mutation research 2008;646(1-2):50-9.
2006: Tatiana Cheusova; Muhammad Amir Khan; Steffen Wolfgang Schubert; Anne-Claude Gavin; Thierry Buchou; Germaine Jacob; Heinrich Sticht; Jorge E Allende; Brigitte Boldyreff; Hans Rudolf Brenner; Said Hashemolhosseini
Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction.
Genes & development 2006;20(13):1800-16.
2006: Birgitte B Olsen; Brigitte Boldyreff; Karsten Niefind; Olaf-Georg Issinger
Purification and characterization of the CK2alpha'-based holoenzyme, an isozyme of CK2alpha: a comparative analysis.
Protein expression and purification 2006;47(2):651-61.
2005: Tine Rasmussen; Iben H E Skjøth; Hans H Jensen; Karsten Niefind; Brigitte Boldyreff; Olaf-Georg Issinger
Biochemical characterization of the recombinant human Drosophila homologues Timekeeper and Andante involved in the Drosophila circadian oscillator.
Molecular and cellular biochemistry 2005;274(1-2):151-61.
2005: Olivier Blond; Hans H Jensen; Thierry Buchou; Claude Cochet; Olaf-Georg Issinger; Brigitte Boldyreff
Knocking out the regulatory beta subunit of protein kinase CK2 in mice: gene dosage effects in ES cells and embryos.
Molecular and cellular biochemistry 2005;274(1-2):31-7.
2004: Ralf Lösel; Armin Schultz; Brigitte Boldyreff; Martin Wehling
Rapid effects of aldosterone on vascular cells: clinical implications.
Steroids 2004;69(8-9):575-8.
2004: Sabine Braun; Ralf Lösel; Martin Wehling; Brigitte Boldyreff
Aldosterone rapidly activates Src kinase in M-1 cells involving the mineralocorticoid receptor and HSP84.
FEBS letters 2004;570(1-3):69-72.
2004: Brigitte Boldyreff; Martin Wehling
Aldosterone: refreshing a slow hormone by swift action.
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 2004;19():97-100.
2004: Karin Rossol-Haseroth; Qian Zhou; Sabine Braun; Brigitte Boldyreff; Elisabeth Dr. Falkenstein; Martin Wehling; Ralf Lösel
Mineralocorticoid receptor antagonists do not block rapid ERK activation by aldosterone.
Biochemical and biophysical research communications 2004;318(1):281-8.
2003: Brigitte Boldyreff; Martin Wehling
Non-genomic actions of aldosterone: mechanisms and consequences in kidney cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(9):1693-5.
2003: Inessa Ermakova; Brigitte Boldyreff; Olaf-Georg Issinger; Karsten Niefind
Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.
Journal of molecular biology 2003;330(5):925-34.
2003: Birgitte B Olsen; Vibeke Jessen; Peter Højrup; Olaf-Georg Issinger; Brigitte Boldyreff
Protein kinase CK2 phosphorylates the Fas-associated factor FAF1 in vivo and influences its transport into the nucleus.
FEBS letters 2003;546(2-3):218-22.
2003: Brigitte Boldyreff; Martin Wehling
Rapid aldosterone actions: from the membrane to signaling cascades to gene transcription and physiological effects.
The Journal of steroid biochemistry and molecular biology 2003;85(2-5):375-81.
2003: Thierry Buchou; Muriel Vernet; Olivier Blond; Hans H Jensen; Hervé Pointu; Birgitte B Olsen; Claude Cochet; Olaf-Georg Issinger; Brigitte Boldyreff
Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality.
Molecular and cellular biology 2003;23(3):908-15.
2002: Tom E Andersen; Bente Finsen; Andre M Goffinet; Olaf-Georg Issinger; Brigitte Boldyreff
A reeler mutant mouse with a new, spontaneous mutation in the reelin gene.
Brain research. Molecular brain research 2002;105(1-2):153-6.
2002: Alla I Kalmykova; Yuri Y Shevelyov; Oksana Polesskaya; Anna A Dobritsa; Alexandra G Evstafieva; Brigitte Boldyreff; Olaf-Georg Issinger; Vladimir A Gvozdev
CK2(beta)tes gene encodes a testis-specific isoform of the regulatory subunit of casein kinase 2 in Drosophila melanogaster.
European journal of biochemistry / FEBS 2002;269(5):1418-27.
2001: Barbara Guerra; Brigitte Boldyreff; Olaf-Georg Issinger
FAS-associated factor 1 interacts with protein kinase CK2 in vivo upon apoptosis induction.
International journal of oncology 2001;19(6):1117-26.
2001: Hans H Jensen; Majbrit Hjerrild; Barbara Guerra; Martin R Larsen; Peter Højrup; Brigitte Boldyreff
Phosphorylation of the Fas associated factor FAF1 by protein kinase CK2 and identification of serines 289 and 291 as the in vitro phosphorylation sites.
The international journal of biochemistry & cell biology 2001;33(6):577-89.
2001: Nerea Roher; Francesc Miro; Brigitte Boldyreff; Franc Llorens; Maria Plana; Olaf-Georg Issinger; Emilio Itarte
The C-terminal domain of human grp94 protects the catalytic subunit of protein kinase CK2 (CK2alpha) against thermal aggregation. Role of disulfide bonds.
European journal of biochemistry / FEBS 2001;268(2):429-36.
1999: Barbara Guerra; S Siemer; Brigitte Boldyreff; Olaf-Georg Issinger
Protein kinase CK2: evidence for a protein kinase CK2beta subunit fraction, devoid of the catalytic CK2alpha subunit, in mouse brain and testicles.
FEBS letters 1999;462(3):353-7.
1999: S Siemer; D Ornskov; Barbara Guerra; Brigitte Boldyreff; Olaf-Georg Issinger
Determination of mRNA, and protein levels of p53, MDM2 and protein kinase CK2 subunits in F9 cells after treatment with the apoptosis-inducing drugs cisplatin and carboplatin.
The international journal of biochemistry & cell biology 1999;31(6):661-70.
1999: Barbara Guerra; Brigitte Boldyreff; Stefania Sarno; Luca Cesaro; Olaf-Georg Issinger; Lorenzo A Pinna
CK2: a protein kinase in need of control.
Pharmacology & therapeutics 1999;82(2-3):303-13.
1999: Mette Kusk Bøving; R Ahmed; Bo Thomsen; Christian Bendixen; Olaf-Georg Issinger; Brigitte Boldyreff
Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins.
Molecular and cellular biochemistry 1999;191(1-2):51-8.
1997: Brigitte Boldyreff; Olaf-Georg Issinger
A-Raf kinase is a new interacting partner of protein kinase CK2 beta subunit.
FEBS letters 1997;403(2):197-9.
1996: Brigitte Boldyreff; U Mietens; Olaf-Georg Issinger
Structure of protein kinase CK2: dimerization of the human beta-subunit.
FEBS letters 1996;379(2):153-6.
1995: K Appel; P Wagner; Brigitte Boldyreff; Olaf-Georg Issinger; M Montenarh
Mapping of the interaction sites of the growth suppressor protein p53 with the regulatory beta-subunit of protein kinase CK2.
Oncogene 1995;11(10):1971-8.
1995: Brigitte Boldyreff; Olaf-Georg Issinger
Structure of the gene encoding the murine protein kinase CK2 beta subunit.
Genomics 1995;29(1):253-6.
1995: W Nastainczyk; I Schmidt-Spaniol; Brigitte Boldyreff; Olaf-Georg Issinger
Isolation and characterization of a monoclonal anti-protein kinase CK2 beta-subunit antibody of the IgG class for the direct detection of CK2 beta-subunit in tissue cultures of various mammalian species and human tumors.
Hybridoma 1995;14(4):335-9.
1995: M P Bozzetti; S Massari; P Finelli; Flavio Meggio; L A Pinna; Brigitte Boldyreff; Olaf-Georg Issinger; G Palumbo; C Ciriaco; S Bonaccorsi
The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):6067-71.
1995: Flavio Meggio; Brigitte Boldyreff; Oriano Marin; Olaf-Georg Issinger; Lorenzo A Pinna
Phosphorylation and activation of protein kinase CK2 by p34cdc2 are independent events.
European journal of biochemistry / FEBS 1995;230(3):1025-31.
1995: Oriano Marin; Flavio Meggio; Brigitte Boldyreff; Olaf-Georg Issinger; Lorenzo A Pinna
Dissection of the dual function of the beta-subunit of protein kinase CK2 ('casein kinase-2'): a synthetic peptide reproducing the carboxyl-terminal domain mimicks the positive but not the negative effects of the whole protein.
FEBS letters 1995;363(1-2):111-4.
1995: U Hoffmann; R Hecht; Brigitte Boldyreff; Olaf-Georg Issinger
Characterization of the cDNA and three processed pseudogenes from the murine protein kinase CK2 alpha subunit.
Biochimica et biophysica acta 1995;1260(3):337-40.
1995: Stefania Sarno; Brigitte Boldyreff; Oriano Marin; B Guerra; Flavio Meggio; Olaf-Georg Issinger; Lorenzo A Pinna
Mapping the residues of protein kinase CK2 implicated in substrate recognition: mutagenesis of conserved basic residues in the alpha-subunit.
Biochemical and biophysical research communications 1995;206(1):171-9.
1994: Flavio Meggio; Brigitte Boldyreff; Olaf-Georg Issinger; L A Pińna
Casein kinase 2 down-regulation and activation by polybasic peptides are mediated by acidic residues in the 55-64 region of the beta-subunit. A study with calmodulin as phosphorylatable substrate.
Biochemistry 1994;33(14):4336-42.
1994: Brigitte Boldyreff; Flavio Meggio; L A Pinna; Olaf-Georg Issinger
Efficient autophosphorylation and phosphorylation of the beta-subunit by casein kinase-2 require the integrity of an acidic cluster 50 residues downstream from the phosphoacceptor site.
The Journal of biological chemistry 1994;269(7):4827-31.
1994: P Mestres; Brigitte Boldyreff; C Ebensperger; H Hameister; Olaf-Georg Issinger
Expression of casein kinase 2 during mouse embryogenesis.
Acta anatomica 1994;149(1):13-20.
1994: Brigitte Boldyreff; Flavio Meggio; Lorenzo A Pinna; Olaf-Georg Issinger
Protein kinase CK2 structure-function relationship: effects of the beta subunit on reconstitution and activity.
Cellular & molecular biology research 1994;40(5-6):391-9.
1993: Brigitte Boldyreff; P James; W Staudenmann; Olaf-Georg Issinger
Ser2 is the autophosphorylation site in the beta subunit from bicistronically expressed human casein kinase-2 and from native rat liver casein kinase-2 beta.
European journal of biochemistry / FEBS 1993;218(2):515-21.
1993: Brigitte Boldyreff; Flavio Meggio; Lorenzo A Pinna; Olaf-Georg Issinger
Reconstitution of normal and hyperactivated forms of casein kinase-2 by variably mutated beta-subunits.
Biochemistry 1993;32(47):12672-7.
1993: Flavio Meggio; Brigitte Boldyreff; Olaf-Georg Issinger; Lorenzo A Pinna
The autophosphorylation and p34cdc2 phosphorylation sites of casein kinase-2 beta-subunit are not essential for reconstituting the fully-active heterotetrameric holoenzyme.
Biochimica et biophysica acta 1993;1164(2):223-5.
1993: Brigitte Boldyreff; Flavio Meggio; G Dobrowolska; Lorenzo A Pinna; Olaf-Georg Issinger
Expression and characterization of a recombinant maize CK-2 alpha subunit.
Biochimica et biophysica acta 1993;1173(1):32-8.
1992: Brigitte Boldyreff; Flavio Meggio; Lorenzo A Pinna; Olaf-Georg Issinger
Casein kinase-2 structure-function relationship: creation of a set of mutants of the beta subunit that variably surrogate the wildtype beta subunit function.
Biochemical and biophysical research communications 1992;188(1):228-34.
1992: Friedrich A Grässer; S Göttel; P Haiss; Brigitte Boldyreff; Olaf-Georg Issinger; Nikolaus Mueller-Lantzsch
Phosphorylation of the Epstein-Barr virus nuclear antigen 2.
Biochemical and biophysical research communications 1992;186(3):1694-701.
1992: Brigitte Boldyreff; K Wehr; R Hecht; Olaf-Georg Issinger
Identification of four genomic loci highly related to casein-kinase-2-alpha cDNA and characterization of a casein kinase-2-alpha pseudogene within the mouse genome.
Biochemical and biophysical research communications 1992;186(2):723-30.
1992: Olaf-Georg Issinger; C Brockel; Brigitte Boldyreff; J T Pelton
Characterization of the alpha and beta subunits of casein kinase 2 by far-UV CD spectroscopy.
Biochemistry 1992;31(26):6098-103.
1992: Flavio Meggio; Brigitte Boldyreff; Oriano Marin; F Marchiori; John W Perich; Olaf-Georg Issinger; Lorenzo A Pinna
The effect of polylysine on casein-kinase-2 activity is influenced by both the structure of the protein/peptide substrates and the subunit composition of the enzyme.
European journal of biochemistry / FEBS 1992;205(3):939-45.
1992: Brigitte Boldyreff; C Klett; E Göttert; A Geurts van Kessel; H Hameister; Olaf-Georg Issinger
Assignment of casein kinase 2 alpha sequences to two different human chromosomes.
Human genetics 1992;89(1):79-82.
1992: Flavio Meggio; Brigitte Boldyreff; Oriano Marin; Lorenzo A Pinna; Olaf-Georg Issinger
Role of the beta subunit of casein kinase-2 on the stability and specificity of the recombinant reconstituted holoenzyme.
European journal of biochemistry / FEBS 1992;204(1):293-7.
1992: I Schmidt-Spaniol; Brigitte Boldyreff; Olaf-Georg Issinger
Isolation and characterization of a monoclonal anti CK-2 alpha subunit antibody of the IgG1 subclass.
Hybridoma 1992;11(1):53-9.
1991: G Dobrowolska; Brigitte Boldyreff; Olaf-Georg Issinger
Cloning and sequencing of the casein kinase 2 alpha subunit from Zea mays.
Biochimica et biophysica acta 1991;1129(1):139-40.
1991: Nikodem Grankowski; Brigitte Boldyreff; Olaf-Georg Issinger
Isolation and characterization of recombinant human casein kinase II subunits alpha and beta from bacteria.
European journal of biochemistry / FEBS 1991;198(1):25-30.
1991: Brigitte Boldyreff; Klaus B Piontek; I Schmidt-Spaniol; Olaf-Georg Issinger
The beta subunit of casein kinase II: cloning of cDNAs from murine and porcine origin and expression of the porcine sequence as a fusion protein.
Biochimica et biophysica acta 1991;1088(3):439-41.